Academic literature on the topic 'Bone void filler'

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Journal articles on the topic "Bone void filler"

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Anonymous. "Bone Void Filler." Orthopedics 25, no. 4 (April 2002): 440. http://dx.doi.org/10.3928/0147-7447-20020401-24.

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Dvorzhinskiy, Aleksey, Giorgio Perino, Robert Chojnowski, Marjolein C. H. van der Meulen, Mathias P. G. Bostrom, and Xu Yang. "Ceramic composite with gentamicin decreases persistent infection and increases bone formation in a rat model of debrided osteomyelitis." Journal of Bone and Joint Infection 6, no. 7 (July 20, 2021): 283–93. http://dx.doi.org/10.5194/jbji-6-283-2021.

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Abstract. Introduction: Current methods of managing osteomyelitic voids after debridement are inadequate and result in significant morbidity to patients. Synthetic ceramic void fillers are appropriate for non-infected bone defects but serve as a nidus of re-infection in osteomyelitis after debridement. CERAMENT G (CG) is an injectable ceramic bone void filler which contains gentamicin and is currently being evaluated for use in osteomyelitic environments after debridement due to its theoretical ability to serve as a scaffold for healing while eliminating residual bacteria after debridement through the elution of antibiotics. The goal of this study was to evaluate (1) the rate of persistent infection and (2) new bone growth of a debrided osteomyelitic defect in a rat model which has been treated with either gentamicin-impregnated ceramic cement (CERAMENT G) or the same void filler without antibiotics (CERAMENT, CBVF). Methods: Osteomyelitis was generated in the proximal tibia of Sprague Dawley rats, subsequently debrided, and the defect filled with either (1) CG (n=20), (2) CBVF (n=20), or (3) nothing (n=20). Each group was euthanized after 6 weeks. Infection was detected through bacterial culture and histology. Bone growth was quantified using microCT. Results: Infection was not detected in defects treated with CG as compared with 35 % of defects (7/20) treated with CBVF and 50 % (10/20) of empty defects (p=0.001). Bone volume in the defect of CG-treated rats was greater than the CBVF (0.21 vs. 0.17, p=0.021) and empty groups (0.21 vs. 0.11, p<0.001) at 6 weeks after implantation. Conclusions: Ceramic void filler with gentamicin (CERAMENT G) decreased the rate of persistent infection and increased new bone growth as compared to the same void filler without antibiotics (CERAMENT) and an empty defect in a rat model of debrided osteomyelitis.
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Blaha, J. David. "Calcium Sulfate Bone-Void Filler." Orthopedics 21, no. 9 (September 1998): 1017–19. http://dx.doi.org/10.3928/0147-7447-19980901-31.

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Sinha, R., PS Menon, and A. Chakranarayan. "Vitoss Synthetic Cancellous Bone (Void Filler)." Medical Journal Armed Forces India 65, no. 2 (April 2009): 173. http://dx.doi.org/10.1016/s0377-1237(09)80136-6.

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Schendel, Stephen A., and John Peauroi. "Magnesium-Based Bone Cement and Bone Void Filler." Journal of Craniofacial Surgery 20, no. 2 (March 2009): 461–64. http://dx.doi.org/10.1097/scs.0b013e31819b9819.

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Karr, Jeffrey C., Joseph Lauretta, and Georgia Keriazes. "In Vitro Antimicrobial Activity of Calcium Sulfate and Hydroxyapatite (Cerament Bone Void Filler) Discs Using Heat-Sensitive and Non–Heat-sensitive Antibiotics Against Methicillin-Resistant Staphylococcus aureus and Pseudomonas aeruginosa." Journal of the American Podiatric Medical Association 101, no. 2 (March 1, 2011): 146–52. http://dx.doi.org/10.7547/1010146.

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Background: Several absorbable and nonabsorbable antibiotic carrier systems are available in the adjunctive surgical management of osteomyelitis of the foot, ankle, and lower leg. These carrier systems have significant limitations regarding which antibiotics can be successfully incorporated into the carrier vehicle. The calcium sulfate and hydroxyapatite Cerament Bone Void Filler is a biocompatible, absorbable ceramic bone void filler that can successfully deliver multiple heat-stable and heat-unstable antibiotics that have not been generally used before with antibiotic beads in treating musculoskeletal infections. Methods: Cerament Bone Void Filler discs with the antibiotics rifampin, vancomycin, tobramycin, cefazolin, cefepime hydrochloride, vancomycin-tobramycin, piperacillin-tazobactam, ceftazidime, and ticarcillin-clavulanate were tested in vitro against methicillin-resistant Staphylococcus aureus. Results: The zones of inhibition for the Cerament Bone Void Filler antibiotic discs plated against Staphylococcus aureus obtained were 33% to 222% greater than the minimum zones of inhibition breakpoints for bacteria susceptibility as defined by the standard set by the Clinical and Laboratory Standards Institute. Cerament Bone Void Filler discs with the antibiotics plated against Pseudomonas aeruginosa produced zones of inhibition of 93% to 200% greater than the minimum zones of inhibition breakpoints for bacteria susceptibility as defined by the standard set by the Clinical and Laboratory Standards Institute. Conclusions: The calcium sulfate and hydroxyapatite Cerament Bone Void Filler was an excellent carrier vehicle for multiple antibiotics creating in vitro significant zones of inhibition, thus demonstrating susceptibility against Staphylococcus aureus and Pseudomonas aeruginosa, which holds tremendous promise in treating osteomyeilits. (J Am Podiatr Med Assoc 101(2): 146–152, 2011)
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Pilliar, Robert M., Rita A. Kandel, Marc D. Grynpas, John Theodoropoulos, Youxin Hu, Bedilu Allo, and Adele Changoor. "Calcium polyphosphate particulates for bone void filler applications." Journal of Biomedical Materials Research Part B: Applied Biomaterials 105, no. 4 (February 1, 2016): 874–84. http://dx.doi.org/10.1002/jbm.b.33623.

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Punyanitya, Sittiporn, Rungsarit Koonawoot, Warangkul Punyanitya, and Phanlob Chankachang. "A Clinical Trial for Bone Void Filler Made from Derived Hydroxyapatite from Cockle Shell Mixed with Rice Starch." Key Engineering Materials 779 (September 2018): 50–53. http://dx.doi.org/10.4028/www.scientific.net/kem.779.50.

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In this study, we have demonstrated that bone void filler made from hydroxyapatite (HAP) which derived from cockle shell. This sample mixed with rice starch and can be used to augment new bone growth in the empty space defects of damaged hard tissue, such as bone, spine and skull. The chemical compositions of HAP get along with standard specification for composition of ceramic HAP for surgical implants (ASTM International: F1185-88). The starch content was in the safety range of classical cell culture formulation. 60 patients were treated with this bone void filler show successfully healing and recovery, after 6 months period of follow up, confirmed safety and efficacy of the medical device properties. It should be an alternative choice for bone substitute in the future.
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Karr, Jeffrey C. "An Overview of the Percutaneous Antibiotic Delivery Technique for Osteomyelitis Treatment and a Case Study of Calcaneal Osteomyelitis." Journal of the American Podiatric Medical Association 107, no. 6 (November 1, 2017): 511–15. http://dx.doi.org/10.7547/13-047.

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Background:A percutaneous antibiotic delivery technique (PAD-T) used for the adjunctive management of osteomyelitis is presented.Methods:This surgical technique incorporates a calcium sulfate and hydroxyapatite (calcium phosphate) bone void filler acting as a carrier vehicle with either an antibiotic or an antifungal medicine, delivering this combination directly into the area of osteomyelitis.Results:The benefit of the PAD-T is reviewed with a case presentation of a successfully treated calcaneal osteomyelitis.Conclusions:No previously reported PAD-T using a simple bone cortex incision in the adjunctive treatment of osteomyelitis has been reported. The PAD-T safely and effectively uses a calcium sulfate and hydroxyapatite bone void filler carrier vehicle to deliver either an antibiotic or an antifungal medicine directly into the area of osteomyelitis.
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Axén, Niklas, Tobias Persson, Kajsa Björklund, Hakan Engqvist, and Leif Hermansson. "An Injectable Bone Void Filler Cement Based on Ca-Aluminate." Key Engineering Materials 254-256 (December 2003): 265–68. http://dx.doi.org/10.4028/www.scientific.net/kem.254-256.265.

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Dissertations / Theses on the topic "Bone void filler"

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Hasan, Raquib. "Antibiotic Releasing Bone-Void Filler for the Treatment of Osteomyelitis: An Approach to Treat Infection and Aid Bone Regeneration." Diss., North Dakota State University, 2019. https://hdl.handle.net/10365/31351.

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Hasan, Mohammad Raquibul. "Antibiotic Releasing Bone-Void Filler for the Treatment of Osteomyelitis: An Approach to Treat Infection and Aid Bone Regeneration." Diss., North Dakota State University, 2020. https://hdl.handle.net/10365/32077.

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Osteomyelitis or bone infections remain very difficult to treat despite advances in treatment regimens and surgical technics. The bone microenvironment and compromised vasculature in addition to infected prosthesis and implants that were put in the bone during prior surgery impedes the antibiotic partition into the bone from systemic therapy in many cases. Treatment often includes surgical debridement of the infected bone and surrounding tissue, removal of implants, systemic antibiotic therapy accompanied with antibiotic containing bone void filler, in most cases polymethylmethacylate (PMMA) based bone cement. Unfortunately, PMMA has many associated problems, including non-biodegradability, inconsistent antibiotic release, and a surface susceptible to bacterial biofilm growth, ultimately necessitating removal and causing recurrent infections. Thus, recent studies have focused on designing novel bone void filling materials to deliver antibiotics and to support bone regeneration. There are two parts to designing a successful bone void filling device/material:(1) local release antibiotic for infection treatment and (2) development of a bone graft substitute to support bone regrowth. In this study, antibiotic releasing bone void filler (ABVF) putty formulations have been designed and tested. Different formulations were examined in this dissertation to describe the three components of the putty formulation - polymer, drug, and substrate. In the first formulation, different custom-made polymers were used to control drug release; Pro Osteon, a hydroxyapatite (HA) and calcium carbonate based bone graft substitute was used to provide support for bone growth. Finally, vancomycin was used as the antibiotic as it is clinically used to treat Staphylococcus aureus, the primary cause of osteomyelitis. In second formulation, commercially available and clinically used polymers, poly(lactic-co-glycolic acid) (PLGA), polycaprolactone (PCL) and, polyethylene glycol (PEG), were used to make the ABVF putty along with Pro Osteon and vancomycin. In the subsequent formulations, delivering combination antibiotics - vancomycin and rifampicin - to treat biofilm infections and, using bioglass (BG) as the substrate for faster bone regrowth were explored; PLGA, PCL and PEG constituted the polymer matrix. The ABVF putty formulations were customizable in terms of three primary components: polymers, bone graft substitutes, antibiotics. Ultimately, these were successful in curing infection and providing bone growth support.
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Åberg, Jonas. "Premixed Acidic Calcium Phosphate Cements." Doctoral thesis, Uppsala universitet, Tillämpad materialvetenskap, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-168650.

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Calcium phosphate cements are used in medicine to fill bone defects or give support to screws and plates in fracture fixation. The cements are formed via mixing a powder with water and the mixture harden through a dissolution-precipitation reaction. Today the cement mixing is performed in the operating room and consists of several complicated steps that need to be performed under sterile conditions. This renders the mixing a risk factor, potentially leading to harm for the patient e.g. unsatisfactory healing or infection. To reduce this risk, premixed cements have been developed using glycerol as mixing liquid. The premixed cement sets when it is exposed to body liquids. Therefore, premixed cement can be delivered to the operating room in prefilled syringes ready for use, thus eliminating the mixing step. The aim of this thesis is to describe differences between premixed and water-mixed cements and their advantages and drawbacks. The differences will be discussed based on results obtained from bench testing of specific cement properties as function of cement formulations as well as in vitro and in vivo studies. Several cement formulations were evaluated e.g. the influence of powder to liquid ratio (P/L), powder particle size and addition of water on key properties. The results showed that premixed cements have excellent handling properties and have mechanical properties similar to water-based cements. Both P/L and particle size can be used to control these properties. It was shown that small amounts of water improve certain cement properties while dry raw materials were important for long shelf life. To better understand the setting of premixed cements new methods for evaluating working time and setting of premixed cements were developed. In vivo studies showed that the formulations developed in this thesis are biocompatible, resorbable and show good tissue response in bone. This thesis concludes, that the premixed cements are a promising biomaterial with excellent handling properties and good biological response. The most important challenge for the premixed cements, in order to become commercially successful, is to obtain clinically relevant setting time and shelf life simultaneously. An increasing use of premixed cements in the clinics should shorten operation times and reduce infection rates to the benefit of both patients and medical staff.
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Ajaxon, Ingrid. "Can Bone Void Fillers Carry Load? : Behaviour of Calcium Phosphate Cements Under Different Loading Scenarios." Doctoral thesis, Uppsala universitet, Tillämpad materialvetenskap, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-316656.

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Calcium phosphate cements (CPCs) are used as bone void fillers and as complements to hardware in fracture fixation. The aim of this thesis was to investigate the possibilities and limitations of the CPCs’ mechanical properties, and find out if these ceramic bone cements can carry application-specific loads, alone or as part of a construct. Recently developed experimental brushite and apatite cements were found to have a significantly higher strength in compression, tension and flexion compared to the commercially available CPCs chronOS™ Inject and Norian® SRS®. By using a high-resolution measurement technique the elastic moduli of the CPCs were determined and found to be at least twice as high compared to earlier measurements, and closer to cortical bone than trabecular bone. Using the same method, Poisson's ratio for pure CPCs was determined for the first time. A non-destructive porosity measurement method for wet brushite cements was developed, and subsequently used to study the porosity increase during in vitro degradation. The compressive strength of the experimental brushite cement was still higher than that of trabecular bone after 25 weeks of degradation, showing that the cement can carry high loads over a time span sufficiently long for a fracture to heal. This thesis also presents the first ever fatigue results for acidic CPCs, and confirms the importance of testing the materials under cyclic loading as the cements may fail at stress levels much lower than the material’s quasi-static compressive strength. A decrease in fatigue life was found for brushite cements containing higher amounts of monetite. Increasing porosity and testing in a physiological buffer solution (PBS), rather than air, also decreased the fatigue life. However, the experimental brushite cement had a high probability of surviving loads found in the spine when tested in PBS, which has previously never been accomplished for acidic CPCs. In conclusion, available brushite cements may be able to carry the load alone in scenarios where the cortical shell is intact, the loading is mainly compressive, and the expected maximum stress is below 10 MPa. Under such circumstances this CPC may be the preferred choice over less biocompatible and non-degradable materials.
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Raut, Vivek P. "METHODS TO QUANTITATIVELY ASSESS THE PERFORMANCE OF CONNECTIVE TISSUE PROGENITOR CELLS IN RESPONSE TO SURFACE MODIFIED BIOMATERIALS." Case Western Reserve University School of Graduate Studies / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=case1372334668.

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Books on the topic "Bone void filler"

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Son, Wŏn-yong. DBM i pʻoham toen kol chʻungjŏnjae ŭi anjŏngsŏng pʻyŏngka kisul kaebal =: A study of safety evaluation of DBM as bone void filler. [Seoul]: Sikpʻum Ŭiyakpʻum Anjŏnchʻŏng, 2007.

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Book chapters on the topic "Bone void filler"

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Engqvist, Håkan, S. Edlund, Gunilla Gómez-Ortega, Jesper Lööf, and Leif Hermansson. "In Vitro Mechanical Properties of a Calcium Silicate Based Bone Void Filler." In Bioceramics 18, 829–32. Stafa: Trans Tech Publications Ltd., 2006. http://dx.doi.org/10.4028/0-87849-992-x.829.

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Breding, Karin, and Håkan Engqvist. "Strength and Chemical Stability Due to Aging of Two Bone Void Filler Materials." In Bioceramics 20, 315–18. Stafa: Trans Tech Publications Ltd., 2007. http://dx.doi.org/10.4028/0-87849-457-x.315.

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Erbe, Erik M., Ted D. Clineff, and Gina Gualtieri. "Comparison of a new bisphenol-a-glycidyl dimethacrylate-based cortical bone void filler with polymethyl methacrylate." In The Use of Bone Substitutes in Spine Surgery, 63–68. Berlin, Heidelberg: Springer Berlin Heidelberg, 2002. http://dx.doi.org/10.1007/978-3-642-56071-2_10.

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Erbe, E. M., J. G. Marx, T. D. Clineff, and L. D. Bellincampi. "Potential of an ultraporous ß-tricalcium phosphate synthetic cancellous bone void filler and bone marrow aspirate composite graft." In The Use of Bone Substitutes in Spine Surgery, 57–62. Berlin, Heidelberg: Springer Berlin Heidelberg, 2002. http://dx.doi.org/10.1007/978-3-642-56071-2_9.

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Benzel, Edward C., Isador H. Lieberman, and Lisa A. Ferrara. "Bone Void Fillers: Bone and Bone Substitutes." In Spine Surgery, 192–203. Elsevier, 2005. http://dx.doi.org/10.1016/b978-0-443-06616-0.50018-3.

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Mokhtari, S., and A. W. Wren. "Bioactive glasses 2: Composite bone void fillers." In Bioactive Glasses, 365–80. Elsevier, 2018. http://dx.doi.org/10.1016/b978-0-08-100936-9.00018-6.

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Banerjee, Avijit, and Timothy F. Watson. "Restorative materials and their relationship to tooth structure." In Pickard's Guide to Minimally Invasive Operative Dentistry. Oxford University Press, 2015. http://dx.doi.org/10.1093/oso/9780198712091.003.0010.

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Modern restorative materials can be classified in several ways, in terms of their retention (chemically adhesive, macro-, micro- or even nanomechanical), their chemistry (e.g. resin-based vs. acid–base reaction, filler particles), or their clinical properties (e.g. aesthetics, strength, handling). It is essential that these materials are considered closely with the histological substrate to which they will adhere or with which they will interact, in order to understand the complexities of each system and their potential clinical uses. This chapter will outline and discuss aspects of dental materials science to enable the reader to understand and appreciate the links with relevant histology and relate this to the clinical aspects of minimally invasive operative dentistry. Also discussed is dental amalgam, still a popular restorative material among many dentists worldwide, although clinical indications for its use are becoming more limited as treatment rationales change and adhesive materials improve. This text will require supplementation from suitable dental histology and detailed dental material science texts. Dental resin composites are aesthetic, plastic adhesive restorative materials that consist of co-polymerized methacrylate-based resin chains embedding inert filler particles (conferring strength and wear resistance) and requiring a separate adhesive (bonding agent) to micro-/ nano-mechanically bond them to either enamel or dentine, respectively. However, not all modern dental composites are based purely on this methacrylate resin chemistry (see Section 7.2.6). Therefore the term ‘composite resin’ is inappropriate and should not be used. Resin composites have developed over the past 50 years, after the introduction of the acid-etch technique (Buonocore, 1955) and methacrylate monomers (Bowen’s resin—Bis-GMA (1971); see Section 7.2.2). The unset (or uncured) material consists of a mixture of several different types of resin methacrylate monomers, most of which are hydrophobic (water-hating) in nature (see Figure 7.1). The monomer chain length affects certain properties of the resin composite:… • Viscosity (or flowability) of the material. This is important in order to minimize voids trapped within the uncured composite during placement and packing within the depths of a cavity (the stiffer the consistency, the greater the risk of trapping air voids). The shorter the uncured monomer length (and therefore the lower the molecular weight), the lower is its viscosity. Often shorter-length, lower-molecular- weight methacrylate monomers form the basis of the resin chemistry of flowable resin composites, and other diluent molecules may be added.
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Conference papers on the topic "Bone void filler"

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Kempers, R., R. Frizzell, A. Lyons, and A. J. Robinson. "Development of a Metal Micro-Textured Thermal Interface Material." In ASME 2009 InterPACK Conference collocated with the ASME 2009 Summer Heat Transfer Conference and the ASME 2009 3rd International Conference on Energy Sustainability. ASMEDC, 2009. http://dx.doi.org/10.1115/interpack2009-89366.

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Typical thermal interface materials (TIMs) consist of high thermal conductivity solid particles dispersed in a continuous, low thermal conductivity organic compound. Despite using filler materials of very high thermal conductivity, the effective thermal conductivity of these TIMs is often two orders of magnitude lower than the pure filler materials. In addition, dispensing and flow of the particle-matrix composite results in voids being trapped within the bond. To address these issues, a novel metal micro-textured thermal interface material (MMT-TIM) has been developed. This material consists of a thin metal foil with raised micro-scale features that plastically deform under an applied pressure thereby creating a continuous, thermally conductive, path between the mating surfaces. Numerical tools have been developed that couple the mechanical and thermal properties and behaviour of MMT-TIMs as they undergo large-plastic deformation during assembly. This study presents the modelling approach and predictions of MMT-TIM performance based on these numerical techniques. The predictions show good agreement with experimental results, which were obtained using prototype MMT-TIMs and an advanced TIM characterization facility. Finally, a future outlook for this technology is presented based on these promising initial results.
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Huang, Xiao. "Microstructure and Oxidation Behaviour of NGB and WGB Joints With Boron/Silicon Free Nickel Base Braze Alloys." In ASME Turbo Expo 2020: Turbomachinery Technical Conference and Exposition. American Society of Mechanical Engineers, 2020. http://dx.doi.org/10.1115/gt2020-14017.

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Abstract In this study, the microstructure and solidus and liquidus of several Ni-Co-Hf-Zr-Ti-Al braze alloys were first examined with the objective to develop a B and Si free low melting braze alloy for narrow gap (NGB) and wide gap brazing (WGB) and turbine component repair applications. Among various alloys examined, DSC was used to measure the solidus and liquidus during heating and cooling cycles. Following the measurements of liquidus and solidus, the microstructure was evaluated using SEM. Equations for calculating solidus and liquidus based on alloy’s compositions were established and the functions of each elements on these two characteristic temperatures were discussed. One selected alloy with a liquidus of 1201 °C was further employed for NGB and WGB experiments. The results showed that it was able join CMSX-4 at 1240°C without interfacial voids; and with the use of externally applied pressure and extended homogenization treatment the interfacial intermetallic compounds were substantially removed. Furthermore, the same braze alloy was used to fill a large artificial cavity in a WGB scheme at a reduced temperature of 1200°C. The braze alloy was able to fully bond the filler powder alloy in addition to join the two alloys to a IN 738 substrate. Finally, oxidation test was conducted at 1050°C (isothermal in static air) for 100 hours after NGB of CMSX-4 and WGB of IN 738. The results showed that the oxide formed on the standalone braze alloy is very dense and there is no sign of spallation. It contained primarily NiO (+CoO) with no other elements measured. For the NGB joints, large amount of scale spallation was observed on base alloy CMSX-4 while the NGB joint remained spallation free. The oxide formed on the NGB was NiO with partitions of Co, Al, Ti, Cr, and W. The WGB joint region in IN 738 showed oxide scale spallation on the IN 738 substrate side, leaving behind steps and depression on the sample surface. In the WGB joint itself, there were three notable phases after oxidation test, however, no scale spallation could be found. For the majority part of the surface, a Ni-rich oxide covered the surface. There were areas of smaller oxide particles with higher Cr content. Overall, the new boron/silicon free braze alloy was found to be able to join several superalloys in both WGB and NGB schemes without occurrence of defects and the oxidation resistance was superior to both substrate alloys examined in this study.
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