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Journal articles on the topic 'Bones - growth. eng'

Author: Grafiati

Published: 4 June 2021

Last updated: 14 February 2022

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1

Hagan, Michael. "Sticks and Bones." Arithmetic Teacher 33, no. 1 (1985): 44–45. http://dx.doi.org/10.5951/at.33.1.0044.

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The proliferation of both teacher-made and professionally prepared games might easily tempt a teacher to conclude that using them to kindle a child's interest in mathematics is an end in itself. And yet the full riches of many games may lie undiscovered until children are challenged to go beyond their interests, to think about their actions, and to elaborate on them. From this perspective, the most valuable games are those that interest children and that have rich variations to encourage their growth.

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Chagin, Andrei S., Elham Karimian, Katja Sundström, Emma Eriksson, and Lars Sävendahl. "Catch-up growth after dexamethasone withdrawal occurs in cultured postnatal rat metatarsal bones." Journal of Endocrinology 204, no. 1 (2009): 21–29. http://dx.doi.org/10.1677/joe-09-0307.

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Children exposed to systemic glucocorticoids often exhibit growth retardation and after the cessation of therapy catch-up growth occurs in many, but not all patients. The developmental regulation and underlying cellular mechanisms of catch-up growth are not fully understood. To clarify this issue, we established an in vitro model of catch-up growth. Here we present a protocol for the long-term culture (up to 160 days) of fetal (E20) as well as postnatal (P8) rat metatarsal bones which allowed us to characterize ex vivo the phenomenon of catch-up growth without any influence by systemic factors

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DiGiancamillo, Mauro, Giovanni Rattegni, Michela Podestà, Luigi Cagnolaro, Bruno Cozzi, and Leo Leonardi. "Postnatal ossification of the thoracic limb in striped dolphins (Stenella coeruleoalba) (Meyen, 1833) from the Mediterranean Sea." Canadian Journal of Zoology 76, no. 7 (1998): 1286–93. http://dx.doi.org/10.1139/z98-055.

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We analyzed the thoracic limbs of 24 striped dolphins, Stenella coeruleoalba, by means of X-ray techniques. The body length of the dolphins, the number of postnatal dentine growth layers in the teeth, the degree of ossification of the hyoid bones, and development of the gonads (when available) were correlated with X-rays and used to estimate growth stages and skeletal maturity. Newborn animals showed advanced ossification centers in the humerus and at the proximal end of the radius and ulna. The proximal end of the humerus and the distal end of the radius and ulna ossify later, followed by clo

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4

Mahgoub, O., and G. A. Lodge. "Growth and body composition of Omani local sheep 2. Growth and distribution of musculature and skeleton." Animal Science 58, no. 3 (1994): 373–79. http://dx.doi.org/10.1017/s0003356100007315.

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AbstractDistribution of tissue weight in the musculature and skeleton was studied in ram, wether and ewe Omani sheep raised under an intensive management system and slaughtered over the range 18 to 38 kg live weight. Ram lambs had higher muscle weight in the forequarters than wether and ewe lambs whereas the latter ‘sexes’ had heavier hindquarters and slightly more muscle in the muscle groups of proximal hind- and forelimbs and those surrounding the spinal column. Some of the neck region muscles, e.g. m. splenius and m. longissimus capitis et atlantis, were more developed in ram than in wether

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Gregg, John B., and Larry J. Zimmerman. "Malnutrition in Fourteenth-Century South Dakota: Osteopathological Manifestations." North American Archaeologist 7, no. 3 (1987): 191–214. http://dx.doi.org/10.2190/m698-gja3-um3p-qrc9.

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Analysis of mutilated skeletons representing people massacred at the fourteenth-century Crow Creek village on the Missouri River bluffs in central proto-South Dakota provided information implicating metabolic deficiencies as significant factors in the catastrophe. Prominent findings were: lines in long bones indicating metabolic stress during growth; superior orbital plate, skull surface, and long bone changes attributable to iron deficiency anemia; decreased bone cortex density and marrow space modifications suggesting the effect of anemia or malnutrition; surface markings near juvenile long

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Perelmuter, M. N. "A criterion for the growth of cracks with bonds in the end zone." Journal of Applied Mathematics and Mechanics 71, no. 1 (2007): 137–53. http://dx.doi.org/10.1016/j.jappmathmech.2007.03.002.

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Pennisi, Angela, Xin Li, Bart Barlogie, John Shaughnessy PhD, and Shmuel Yaccoby. "Consequences of Intermittent PTH Treatment on Myeloma Growth, Bone Disease and Molecular Profiling of Whole Myelomatous Bone." Blood 116, no. 21 (2010): 4063. http://dx.doi.org/10.1182/blood.v116.21.4063.4063.

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Abstract Abstract 4063 Intermittent PTH (iPTH) treatment is bone anabolic and has been successfully used for treatment of osteoporosis. The aims of the study were to investigate the effects of iPTH-induced bone formation on myeloma progression and unravel molecular mechanisms associated with these effects, using the SCID-rab and SCID-hu models. Using our reported procedure (Xin et al., BJH 2007), we established a novel myeloma cell line, Hg, capable of sequential passaging in experimental models. Hg cells have similar gene expression profiling (GEP) as the original patient's plasma cells, are

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Gupta, Anil Kumar, and M. N. Ambekar. "Study Of Nutrient Foramina In Adult Human Femur Bones." Journal of Nepalgunj Medical College 14, no. 2 (2018): 44–49. http://dx.doi.org/10.3126/jngmc.v14i2.21538.

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Background: The role of nutrient foramen (NF) in nutrition and growth of the bones is evident from term Nutrient itself. The nutrient foramen is opening of nutrient canal on the surface of shaft of the bone which conducts the nutrient artery and the peripheral nerves to bones. Long bones receive most of the interosseous blood supply (70% to 80%) from the nutrient arteries and remaning (20% to 30%) through the periosteal vessels. Nutrient arteries play an important role in nutrition and growth of the bones particularly during early phases of ossification and growth. The present study is of grea

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Seely, Daniel R., and George A. Gates. "Parosteal Osteogenic Sarcoma of the Mastoid Bone." Annals of Otology, Rhinology & Laryngology 106, no. 9 (1997): 729–32. http://dx.doi.org/10.1177/000348949710600902.

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Parosteal osteogenic sarcoma (POS) is an uncommon surface bone tumor, most often arising from the metaphyseal end of long bones. Involvement of the cranial bones is rare, with only 1 case of mastoid bone POS previously reported in the literature. Two patients with POS of the mastoid are presented, 1 followed up for 25 years after surgical treatment. The presenting signs and symptoms, as well as distinctive radiographic findings, are discussed. Histologic features are also described. Typically, cranial POS appears as a sessile, densely ossified surface growth with radiating bone spicules that b

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Huttenlocker, Adam K., and Jennifer Botha-Brink. "Body size and growth patterns in the therocephalianMoschorhinus kitchingi(Therapsida: Eutheriodontia) before and after the end-Permian extinction in South Africa." Paleobiology 39, no. 2 (2013): 253–77. http://dx.doi.org/10.1666/12020.

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The continuous fossil record of therocephalian therapsids (Eutheriodontia) across the Permo-Triassic boundary and their differential survivorship of the end-Permian extinction offer an exceptional deep-time perspective on vertebrate life-history evolution during episodes of large-scale ecological perturbation. To examine potential impacts of the extinction on body size evolution (e.g., “Lilliput” effects) and growth patterns, we investigated cranial sizes and limb bone histology in the therocephalianMoschorhinus kitchingiboth before and after the end-Permian extinction, facilitated by analysis

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Kashimada, K., T. Yamashita, K. Tsuji, et al. "Defects in growth and bone metabolism in klotho mutant mice are resistant to GH treatment." Journal of Endocrinology 174, no. 3 (2002): 403–10. http://dx.doi.org/10.1677/joe.0.1740403.

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Klotho mutant (kl/kl) mice exhibit growth retardation after weaning, and previous electron microscopic examination of GH-producing cells in pituitary glands revealed a reduction in GH granules. However, it has not been known whether growth retardation in klotho mutant mice is related to the loss of GH function. We therefore examined whether treatment with GH could rescue the retardation of growth. At the end of 3 weeks of treatment with human GH, the body weight of wild-type (WT) mice was increased. In contrast, body weight was not increased in klotho mutant mice even after the treatment with

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Sproule, James A., Simon J. Roche, and Eswara G. Murthy. "ATTRITIONAL RUPTURE OF EXTENSOR POLLICIS LONGUS: A RARE COMPLICATION FOLLOWING ELASTIC STABLE INTRAMEDULLARY NAILING OF A PAEDIATRIC RADIAL FRACTURE." Hand Surgery 16, no. 01 (2011): 69–72. http://dx.doi.org/10.1142/s0218810411005163.

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Elastic stable intramedullary nail fixation has become established as an acceptable method of treatment for diaphyseal fractures of both forearm bones in the paediatric population. It is considered safe, minimally invasive and does not compromise physeal growth. We report a case of delayed rupture of extensor pollicis longus due to attrition over the sharp edges of a protruding nail end after elastic stable intramedullary nailing of a paediatric radial diaphyseal fracture.

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Larson, Bruce C., W. Keith Moser, and Vijay K. Mishra. "Some Relationships Between Silvicultural Treatments and Symmetry of Stem Growth in a Red Pine Stand." Northern Journal of Applied Forestry 15, no. 2 (1998): 90–93. http://dx.doi.org/10.1093/njaf/15.2.90.

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Abstract Variations in spacing and the distribution of removed trees have been assumed to affect the pattern of growth on tree boles. Changing crown shapes were believed to affect the symmetry of the stems. This study examined the change of growing space resulting from differential species' growth in a mixed stand. A red pine (Pinus resinosa Ait.) plantation in southern New Hampshire was planted at 2 × 2 m spacing in 1917. At one end of the stand every second row was planted with white pine (Pinus strobus L.), whereas the other end of the stand was pure red pine. In the mixed portion of the st

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Larson, Sven. "Balancing the budget: can the Swiss debt brake end endless U.S. deficits?" Journal of Governance and Regulation 5, no. 4 (2016): 99–105. http://dx.doi.org/10.22495/jgr_v5_i4_p9.

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The United States is the world’s leading issuer of treasury bonds, and according to current forecasts there is no end in sight to annual budget deficits. Evidence strongly suggests that persistent deficits are closely associated with depressed growth, raising the possibility that a permanent end to U.S. deficits would permanently increase the country’s economic growth. However, with nearly a half-century long, almost unbroken line of deficits it is unlikely that Congress will rise to the occasion and end borrowing on its own. Suggesting that the United States needs budget-balancing regulations

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Whitehead, C. C., J. S. Rennie, C. Farquharson, and R. H. Fleming. "Recent findings on tibial dyschondroplasia in broilers and osteoporosis in caged layers." Proceedings of the British Society of Animal Production (1972) 1993 (March 1993): 70. http://dx.doi.org/10.1017/s0308229600023965.

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The skeletal disorders causing the most severe welfare problems in different classes of poultry are bone growth disorders in young birds and bone fragility in older laying hens.Angular and rotational deformities of leg bones are widespread in young birds, especially in broilers but also in turkeys. Dyschondroplasia is a widely observed defect in the growth plates of leg bones. It occurs most noticeably in the growth plate of the proximal tibia, the fastest growing bone in the young broiler, and is frequently referred to as tibial dyschondroplasia (TD). Resulting from a failure of growth plate

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Corsi, Alessandro, Mara Riminucci, Mario Roggini, and Paolo Bianco. "Short Rib Polydactyly Syndrome Type III: Histopathogenesis of the Skeletal Phenotype." Pediatric and Developmental Pathology 5, no. 1 (2002): 91–96. http://dx.doi.org/10.1007/s10024-001-0122-2.

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A morphological study of the skeletal system in a case of short rib polydactyly syndrome type III (SRPS-III) documented a “bajonet” deformity of the ribs for misalignment and overlap of cartilaginous and bony ends. This deformity resulted from a ‘tandem’ change in endochondral bone formation that is, arrested orthotopic cartilage maturation and etherotopic perichondral cartilage differention and ossification. At the cartilaginous end, cartilage maturation and vascular invasion were absent. At the bony end, longitudinal bone growth occurred by a perichondral ectopic growth plate. ‘Miniature’ ve

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Tauer, Josephine Tabea, Lorenz C. Hofbauer, and Meinolf Suttorp. "Impact Of The Tyrosine Kinase Inhibitors Imatinib, Dasatinib, and Bosutinib In Young Rats On The Vertebral Body." Blood 122, no. 21 (2013): 1472. http://dx.doi.org/10.1182/blood.v122.21.1472.1472.

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Abstract Background Tyrosine kinase inhibitors (TKIs) such as imatinib (IMA), dasatinib (DASA), and bosutinib (BOSU) inhibit the oncogenic BCR-ABL tyrosine kinase in patients with chronic myeloid leukemia (CML). In addition, all TKIs exhibit additional off-target effects on kinases like PDGF-R and c-FMS which are involved in the regulation of bone metabolism. In pediatric patients longitudinal growth retardation during IMA treatment represents a major side effect causing special concern. In an established juvenile growing rat model (Tauer JT et al. Blood 2011, ASH Abstract #1597) we examined s

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Davis, A. P., and M. R. Capecchi. "Axial homeosis and appendicular skeleton defects in mice with a targeted disruption of hoxd-11." Development 120, no. 8 (1994): 2187–98. http://dx.doi.org/10.1242/dev.120.8.2187.

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Using gene targeting, we have created mice with a disruption in the homeobox-containing gene hoxd-11. Homozygous mutants are viable and the only outwardly apparent abnormality is male infertility. Skeletons of mutant mice show a homeotic transformation that repatterns the sacrum such that each vertebra adopts the structure of the next most anterior vertebra. Defects are also seen in the bones of the limb, including regional malformations at the distal end of the forelimb affecting the length and structure of phalanges and metacarpals, inappropriate fusions between wrist bones, and defects at t

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Marongiu, Giuseppe, Andrea Contini, Andrea Cozzi Lepri, Matthew Donadu, Marco Verona, and Antonio Capone. "The Treatment of Acute Diaphyseal Long-bones Fractures with Orthobiologics and Pharmacological Interventions for Bone Healing Enhancement: A Systematic Review of Clinical Evidence." Bioengineering 7, no. 1 (2020): 22. http://dx.doi.org/10.3390/bioengineering7010022.

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Background: The healing of long bones diaphyseal fractures can be often impaired and eventually end into delayed union and non-union. A number of therapeutic strategies have been proposed in combination with surgical treatment in order to enhance the healing process, such as scaffolds, growth factors, cell therapies and systemic pharmacological treatments. Our aim was to investigate the current evidence of bone healing enhancement of acute long bone diaphyseal fractures. Methods: A systematic review was conducted by using Pubmed/MEDLINE; Embase and Ovid databases. The combination of the search

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Hanafi, Ulfiani Fauzia, Yeni Dhamayanti, Muhammad Thohawi Elziyad Purnama, Soeharsono Soeharsono, Prima Ayu Wibawati, and Ragil Angga Prastiya. "Hindlimb Osteometry of Lohmann Broiler on 7, 21 and 35 days." Jurnal Medik Veteriner 4, no. 1 (2021): 23. http://dx.doi.org/10.20473/jmv.vol4.iss1.2021.23-36.

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Patterns of growth can be determined one of them through quantitative measurements, namely osteometry. The aim of this study was to determine the growth of patterns of Lohmann broiler chickens based on hindlimb osteometry at the age of 7, 21 and 35 days. This study used 30 Lohmann broiler chickens aged 7, 21 and 35 days. Osteometry techniques are performed on all the bones of hindlimb with variable Greatest length (GL), Breadth of the proximal end (Bp), Breadth of the distal end (Dd), Minimum breadth of diaphysis (Sd), Circular of the proximal end (Cp), Circular of corpus (Cc), and Circular of

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Zhu, Zimo, Donna C. Jones, G. R. Liu та ін. "Automated Segmentation of Swine Skulls for Finite Element Model Creation Using High Resolution μ-CT Images". International Journal of Computational Methods 16, № 03 (2019): 1842012. http://dx.doi.org/10.1142/s0219876218420124.

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Finite element (FE) analysis has been widely used to investigate bone responses to mechanical loading. Research in long bones has been straight forward because modeling of these bones requires only two material properties. Such an FE model may provide an adequate approximation of the anatomy for many cases. However, a more detailed model of skull bones is needed to accurately capture its complex structure of multiple bone pieces and the various mineral densities distributed throughout these bone pieces. Unfortunately, FE model development incorporating both complex geometries and anatomically

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Staal, Heleen M., John Derwall, Adhiambo M. Witlox, and Lodewijk W. van Rhijn. "Time-lapse technic used to uncover the naturel growth of osteochondromas of the wrist in patients with Hereditary Multiple Osteochondromas." International Journal of Diagnostic Imaging 4, no. 2 (2017): 57. http://dx.doi.org/10.5430/ijdi.v4n2p57.

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Background: In patients with Hereditary Multiple Osteochondromas (HMO) shortening and deformity of the long bones is a well-known sequel. Several theories could clarify the cause of shortening or deformity.Methods: To reveal the development of the long bones and the influence of the osteochondromas on the growth we used time-lapse technique. Radiographic images, taken for clinical reasons, of 6 HMO affected patients with known osteochondromas on the distal end of the lower arm were selected and adapted to make them suitable for use with a time-lapse technique. The images were placed in chronol

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KAMATA, Tetsuji, Hironobu AMBO, Wilma PUZON-McLAUGHLIN, et al. "Critical cysteine residues for regulation of integrin alphaIIbbeta3 are clustered in the epidermal growth factor domains of the beta3 subunit." Biochemical Journal 378, no. 3 (2004): 1079–82. http://dx.doi.org/10.1042/bj20031701.

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Chemical or enzymic reduction/oxidation of integrin cysteine residues (e.g. by reducing agents and protein disulphide isomerase) may be a mechanism for regulating integrin function. It has also been proposed that unique cysteine residues in the integrin β3 subunit are involved in the regulation of αIIbβ3. In the present study, we studied systematically the role of disulphide bonds in β3 on the ligand-binding function of αIIbβ3 by mutating individual cysteine residues of β3 to serine. We found that the disulphide bonds that are critical for αIIbβ3 regulation are clustered within the EGF (epider

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Lezon, Christian, Clarisa Bozzini, Alan Agûero Romero, et al. "Effect of chronic undernutrition on body mass and mechanical bone quality under normoxic and altitude hypoxic conditions." British Journal of Nutrition 115, no. 9 (2016): 1687–95. http://dx.doi.org/10.1017/s000711451600060x.

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AbstractBoth undernutrition and hypoxia exert a negative influence on both growth pattern and bone mechanical properties in developing rats. The present study explored the effects of chronic food restriction on both variables in growing rats exposed to simulated high-altitude hypoxia. Male rats (n 80) aged 28 d were divided into normoxic (Nx) and hypoxic (Hx) groups. Hx rats were exposed to hypobaric air (380 mmHg) in decompression chambers. At T0, Nx and Hx rats were subdivided into four equal subgroups: normoxic control and hypoxic controls, and normoxic growth-restricted and hypoxic growth-

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Ehrenkranz, Joel, and Michael A. Levine. "Bones and Joints: The Effects of Cannabinoids on the Skeleton." Journal of Clinical Endocrinology & Metabolism 104, no. 10 (2019): 4683–94. http://dx.doi.org/10.1210/jc.2019-00665.

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Abstract Context The endocannabinoid system uses tissue-specific lipid ligands and G protein‒coupled transmembrane receptors to regulate neurologic, metabolic, and immune responses. Recent studies demonstrate that the endocannabinoid system influences bone metabolism. With the increasing use of endocannabinoid mimetics (e.g., tetrahydrocannabinol and cannabidiol), the involvement of endocannabinoids in bone growth and remodeling has become clinically relevant. Evidence Acquisition This literature review is based on a search of PubMed and Google Scholar databases as of June 2019 for all English

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Branca, Francesco, and Silvia Vatueña. "Calcium, physical activity and bone health – building bones for a stronger future." Public Health Nutrition 4, no. 1a (2001): 117–23. http://dx.doi.org/10.1079/phn2000105.

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AbstractAdequate provision of nutrients composing the bone matrix and regulating bone metabolism should be provided from birth in order to achieve maximal bone mass, compatible with individual genetic background, and to prevent osteoporosis later in life. Low calcium intake (<250 mg day−1) in children is associated with both a reduced bone mineral content and hyperparathyroidism. Optimal calcium intake is, however, still a matter of controversy. The minimisation of fracture risk would be the ideal functional outcome on which to evaluate lifetime calcium intakes, but proxy indicators, such a

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GOULART, Fernanda Rodrigues, Caroline Sefrin SPERONI, Naglezi de Menezes LOVATTO, et al. "Alternative protein sources in nutrition and metabolism of jundiá:in nature and demucilaged linseed meal." Revista Brasileira de Saúde e Produção Animal 16, no. 1 (2015): 244–52. http://dx.doi.org/10.1590/s1519-99402015000100025.

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<p>This study evaluated the growth response and metabolic effects of partial replacement of animal protein source with <italic>in natura</italic> (LM) or demucilaged (DLM) linseed meal in the diet of jundiá <italic>(Rhamdia quelen</italic>) juveniles. After demucilagen increased crude protein content and reduced soluble fiber of linseed meal. During seven weeks, 240 jundiá juveniles were reared in water recirculation system and fed to apparent satiation with the following diets: control diet (meat and bones meal and soybean protein concentrate as the main protein

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Bacon, G. E., and A. E. Goodship. "The healing process for fractured tibia bones of sheep studied by neutron diffraction." Journal of Applied Crystallography 40, no. 2 (2007): 349–53. http://dx.doi.org/10.1107/s002188980700430x.

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Neutron diffraction has shown directly that the long bones of animals have thecaxes of their apatite crystals preferentially oriented to withstand stresses. When a sheep tibia is fractured and allowed to heal, the jointing material is initially randomly arranged, but a return of some orientation occurs after a few months. This orientation increases slowly with time. The growth of callus bone around the outside of the fracture becomes overshadowed by the appearance of poorly oriented internal bone. After 22 months, the end of this experiment, the process of bone restoration is still far from co

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Straková, E., R. Pospíšil, P. Suchý, L. Steinhauser, and I. Herzig. "Administration of Clinoptilolite to Broiler Chickens During Growth and Its Effect on the Growth Rate and Bone Metabolism Indicators." Acta Veterinaria Brno 77, no. 2 (2008): 199–207. http://dx.doi.org/10.2754/avb200877020199.

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The growth rate and bone metabolism indicators were monitored in broiler chickens receiving the feed supplemented with clinoptilolite. One-day-old broiler chickens ROSS 308 were divided into control (C) and experimental (E) groups with 100 males and 100 females per group. The chickens received the complete feed mixture BR1 from 1 to 10 days of age, followed by the feed mixture BR2 until the age of 30 days, and the feed mixture BR3 until the end of the experiment (40 days). The feed mixtures of the experimental group were supplemented with clinoptilolite (commercial additive ZeoFeed) at a level

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Tajchman, Katarzyna, Marek Bogdaszewski, and Edyta Kowalczuk-Vasilev. "Effects of supplementation with different levels of calcium and phosphorus on mineral content of first antler, bone, muscle, and liver of farmed fallow deer (Dama dama)." Canadian Journal of Animal Science 100, no. 1 (2020): 17–26. http://dx.doi.org/10.1139/cjas-2018-0234.

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Nutrition is one of the main factors influencing physiological processes, e.g., growth and antler development, in Cervidae. The aim of this study was to demonstrate a possible effect of supplementation with different levels of calcium (Ca) and phosphorus (P) on the mineral composition of antlers and bones, and its effect on the content of macroelements — Ca, potassium (K), magnesium (Mg), sodium (Na), and P — in the muscle tissue, liver, and blood of farmed fallow deer fawns. The results show a positive effect of increased doses of Ca and P on body weight at the age of 14 mo. Additionally, the

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Han, Fenglu, Qi Zhao, and Jun Liu. "Preliminary bone histological analysis of Lystrosaurus (Therapsida: Dicynodontia) from the Lower Triassic of North China, and its implication for lifestyle and environments after the end-Permian extinction." PLOS ONE 16, no. 3 (2021): e0248681. http://dx.doi.org/10.1371/journal.pone.0248681.

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Lystrosaurus represents one of the most successful dicynodonts, a survivor of the end-Permian mass extinction that remained abundant in the Early Triassic, but many aspects of its paleobiology are still controversial. The bone histology of Lystrosaurus species from South Africa and India has provided important information on their growth strategy and lifestyle, but until recently no data was available on the bone histology of Lystrosaurus from China. Here, we report on the bone microstructure of seven Lystrosaurus individuals from the Lower Triassic of Xinjiang, providing the first such data f

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Li, Xin, Sarah K. Johnson, Wen Ling, et al. "Inducible Heme Oxygenase 1 (HMOX1) Promotes Osteoblastogenesis, and Inhibits Osteoclastogenesis and Myeloma-Induced Bone Disease." Blood 118, no. 21 (2011): 627. http://dx.doi.org/10.1182/blood.v118.21.627.627.

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Abstract Abstract 627 Cytotherapy with mesenchymal stem cells (MSCs) has been shown to promote bone formation, inhibit bone disease and reduce multiple myeloma (MM) growth in myelomatous bone (Yaccoby et al., 2006; Li et al., 2011). At the cellular level, the infused MSCs act as a bystander cells that activate endogenous osteoblasts and suppress osteoclast activity. To shed light on molecular mechanisms associated with the cytotherapeutic effects of MSCs we exploited the SCID-hu model engrafted with the Hg MM line. Hg cells are only maintained by passaging in SCID-hu/SCID-rab mice and produce

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Palkar, Vaibhav, Chandan K. Choudhury, and Olga Kuksenok. "Development of Dissipative Particle Dynamics framework for modeling hydrogels with degradable bonds." MRS Advances 5, no. 17 (2020): 927–34. http://dx.doi.org/10.1557/adv.2020.148.

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AbstractControlled degradation of hydrogels enables several applications of these materials, including controlled drug and cell release applications and directed growth of neural networks. These applications motivate the need of a simulation framework for modeling controlled degradation in hydrogels. We develop a Dissipative Particle Dynamics (DPD) framework for hydrogel degradation. As a model hydrogel, we prepare a network formed by end-linking tetra-arm polyethylene glycol precursors. We model bond breaking during degradation of this hydrogel as a stochastic process. The fraction of degrada

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Turner, Nigel E. "Report from the Global Gaming Expo, Las Vegas, November 17-19, 2009." Journal of Gambling Issues, no. 25 (June 1, 2011): 130. http://dx.doi.org/10.4309/jgi.2011.25.10.

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This paper is a review of the Global Gaming Expo, November 17 to 19, 2009. A number of new innovations in gambling equipment are described, including multi-game slots, multi-player electronic games (e.g., competitive bonus rounds), advances in card-based bonusing systems, and the explosive growth of new electronic table games. In addition, the conference included 3 panel sessions hosted by the National Center for Responsible Gaming.

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Gaucherel, C., J. Guiot, and L. Misson. "Evolution of the potential distribution area of french mediterranean forests under global warming." Biogeosciences Discussions 5, no. 1 (2008): 573–603. http://dx.doi.org/10.5194/bgd-5-573-2008.

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Abstract. This work aims at understanding future spatial and temporal distributions of tree species in the Mediterranean region of France under various climates. We focused on two different species (Pinus Halepensis and Quercus Ilex) and compared their growth under the IPCC-B2 climate scenario in order to quantify significant changes between present and future. The influence of environmental factors such as atmospheric CO2 increase and topography on the tree growth has also been quantified. We modeled species growths with the help of a process-based model (MAIDEN), previously calibrated over m

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Calixto, Luis Fernando, Rodrigo Penagos, Lina Jaramillo, María Lucia Guitierrez, and Diego Garzón-Alvarado. "A Histological Study of Postnatal Development of Clavicle Articular Ends." Universitas Scientiarum 20, no. 3 (2015): 361. http://dx.doi.org/10.11144/javeriana.sc20-3.ahso.

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The clavicle is the first bone to begin the process of ossification and the last one to complete it. Whilst histological studies of the clavicle have been focused mainly on embryonic events, our study focused on post natal clavicle development. The objective of this study was to perform a qualitative description of the clavicle’s epiphyseal growth to further shed light on the postnatal ossification process. Histological studies performed on clavicles obtained from cadavers confirmed medial and lateral extremities as true physes. Unlike the development of other long bones, no secondary ossifica

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Yang, Xiao Xiang, and Xiao Fang Li. "Tearing Energy for Crack Growth at the Bonds of Cylindrical Rubber Bushes Subjected to Axial Shear." Key Engineering Materials 353-358 (September 2007): 211–14. http://dx.doi.org/10.4028/www.scientific.net/kem.353-358.211.

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We applied the fracture mechanics approach and the nonlinear finite element method to the analysis of interfacial failure in cylinder rubber bush bonded on their outer and inner curves surfaces to rigid metal cylinders. The fracture parameter, tearing energy for rubber bushes was calculated using global energy change. The contact of interfacial crack during deformation was considered. The analyses for initially small cracks and relatively large cracks growing downwards disagree with the previous linear solutions. The variation tearing energy for cracks growing upwards is consistent with the ex

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Cole, Heather A., Hernan Correa, and Jonathan G. Schoenecker. "A Subdermal Osteochondroma in a Young Girl." Case Reports in Orthopedics 2017 (2017): 1–4. http://dx.doi.org/10.1155/2017/8672816.

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Osteochondromas are common benign tumors of cartilage and bone. They are usually found as contiguous bone with a cartilage cap at the end of the growth plate of long bones. Similar to structure are extraskeletal osteochondromas. However, unlike typical osteochondromas, extraskeletal osteochondromas are noncontinuous with bone. To our knowledge, all reported extraskeletal osteochondromas have been contained within fascial compartments. Here we present the case of a 5-year-old female who had a slow growing mass of the anterior distal right thigh. Imaging studies revealed an ossified mass extendi

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Codorniú, Laura, and Luis M. Chiappe. "Early juvenile pterosaurs (Pterodactyloidea: Pterodaustro guinazui) from the Lower Cretaceous of central Argentina." Canadian Journal of Earth Sciences 41, no. 1 (2004): 9–18. http://dx.doi.org/10.1139/e03-080.

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We report on two juvenile specimens of Pterodaustro guinazui, a medium-sized, filter-feeding pterodactyloid pterosaur from the Lower Cretaceous (Albian) lacustrine deposits of the Lagarcito Formation of central Argentina (Sierra de Las Quijadas, San Luis Province). Both specimens lack the skull, but one is otherwise nearly complete and articulated, and the other is more fragmentary. Their small size (~300 mm of wingspan), the lack of fusion of several postcranial bones, the minimal epiphyseal ossification, and the porous appearance of the periosteal surfaces indicate the specimens died at a ve

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Berardi, Andrea, and Alberto Plazzi. "Inflation Risk Premia, Yield Volatility, and Macro Factors." Journal of Financial Econometrics 17, no. 3 (2018): 397–431. http://dx.doi.org/10.1093/jjfinec/nby004.

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Abstract We incorporate a latent stochastic volatility factor and macroeconomic expectations in an affine model for the term structure of nominal and real rates. We estimate the model over 1999–2016 on U.S. data for nominal and TIPS yields, the realized and implied volatility of T-bonds, and survey forecasts of GDP growth and inflation. We find relatively stable inflation risk premia averaging at 40 basis points at the long-end, and which are strongly related to the volatility factor and conditional mean of output growth. We also document real risk premia that turn negative in the post-crisis

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Li, Xin, Wen Ling, Sharmin Khan, et al. "Systemically Injected Mesenchymal Stem Cells Traffic to Myelomatous Bone and Inhibit Bone Disease, and Intralesionally Promotes Bone Formation and Delays Myeloma Progression During the Disease Active Stage or Remission." Blood 116, no. 21 (2010): 980. http://dx.doi.org/10.1182/blood.v116.21.980.980.

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Abstract Abstract 980 Mesenchymal stem cells (MSCs) cytotherapy has been clinically tested in various applications including bone regeneration, autoimmune diseases, and cancer. The aims of the study were to test the effect of MSCs cytotherapy on myeloma (MM) bone disease and tumor growth, and determine their ability to traffic into myelomatous bone during active disease stage and induction of remission by melphalan. We exploited the SCID-rab model for MM and a novel human myeloma cell line, Hg, established through our previously reported procedure (Xin et al., BJH 2007). Hg myeloma cells do no

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Carrière, D., K. L. Fischer, D. B. Peakall, and P. Anghern. "Effects of dietary aluminum sulphate on reproductive success and growth of Ringed Turtle-Doves (Streptopelia risoria)." Canadian Journal of Zoology 64, no. 7 (1986): 1500–1505. http://dx.doi.org/10.1139/z86-224.

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Elevated levels of aluminum have been reported in surface waters and in certain aquatic organisms including aquatic insects. Toxic effects have been demonstrated in fish and it has been suggested that aluminum affects avian reproduction. In this study Ringed Turtle-Doves were assigned to a control group fed a diet reduced in calcium and phosphorus and to a treated group fed the same diet supplemented with 0.1% aluminum. A 4-month feeding period with aluminum sulphate did not result in any effect on egg production, fertility, or hatchability. Egg permeability was decreased initially but subsequ

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Dencheva Tsonkova, Vanya. "THE SOVEREIGN GREEN BONDS MARKET IN THE EUROPEAN UNION: ANALYSIS AND GOOD PRACTICES." KNOWLEDGE INTERNATIONAL JOURNAL 30, no. 1 (2019): 165–72. http://dx.doi.org/10.35120/kij3001165d.

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In a world facing the growing problems of climate change and social differentiation, the so-called ―sustainable finance‖ increases its importance and popularity. The object of this field of study is the transfer of capital flows to projects with clearly defined environmental and social benefits. Key instruments are Green bonds, Social bonds and Sustainability bonds. The article is dedicated to green bonds, focusing on sovereign issues. It is widely known that the green bond market begins its development with the so-called ―supranational‖ issues – the bonds of the international financial instit

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Sperduto, Luke. "Can Human Development Bonds Reduce the Agency Costs of the Resource Curse?" Law and Development Review 12, no. 1 (2019): 191–245. http://dx.doi.org/10.1515/ldr-2018-0061.

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Abstract Especially in resource rich countries with weak institutions of governance, the interests of governments often diverge from those of their citizens and creditors. Sovereign bond contracts can potentially help align these interests, to the benefit of all parties, by indexing payment obligations to improvements in the health and education of the issuer’s citizenry. To that end, this Article proposes a Human Development Bond (HDB) with a variable coupon schedule that both insures issuers against recessions and incentivizes them to encourage investment in human capital when economic growt

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Venkateshaiah, Sathisha Upparahalli, Sharmin Khan, Wen Ling, et al. "NAMPT/PBEF Enzymatic Activity Is Indispensable for Myeloma Cell Growth and Osteoclast Activity." Blood 118, no. 21 (2011): 886. http://dx.doi.org/10.1182/blood.v118.21.886.886.

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Abstract Abstract 886 Clinical MRI and PET-CT analyses implicated hypermetabolic activity of multiple myeloma (MM) cells in focal lesions with tumor burden, metastasis and survival. Osteoclasts induced by MM are also naturally hypermetabolic suggesting that targeting cellular metabolism may contribute to controlling MM and associated bone disease. The coenzyme nicotinamide adenine dinucleotide (NAD) not only is essential for proper cellular metabolism but also affects activity of NAD-dependent enzymes, such as PARP1 and sirtuins. Nicotinamide phosphoribosyl transferase (NAMPT/PBEF/Visfatin) is

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Pllana, Mustafe, and Saranda Tufa. "Fish Market, Consumption and Consumer Behavior." International Journal of Sustainable Economies Management 7, no. 2 (2018): 25–35. http://dx.doi.org/10.4018/ijsem.2018040103.

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This article describes how fish is a primary source of nutrition and fisheries are a primary source of income. The health benefits for people eating fish are: reduction of risk of heart attack, lower blood pressure, reduction of risk of cancer, balancing dietary cholesterol and other health benefits. In addition to health, recreational fishing activity are contributing to a healthier population, where millions of people are finding pleasure but also sporting the fishing industry. Trend growth is expected in the future, even in developed countries. Factors which affect fish consumption are: cul

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Lawera, Aleksandra, Zhen Tong, Midory Thorikay, et al. "Role of soluble endoglin in BMP9 signaling." Proceedings of the National Academy of Sciences 116, no. 36 (2019): 17800–17808. http://dx.doi.org/10.1073/pnas.1816661116.

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Endoglin (ENG) is a coreceptor of the transforming growth factor-β (TGFβ) family signaling complex, which is highly expressed on endothelial cells and plays a key role in angiogenesis. Its extracellular domain can be cleaved and released into the circulation as soluble ENG (sENG). High circulating levels of sENG contribute to the pathogenesis of preeclampsia (PE). Circulating bone morphogenetic protein 9 (BMP9), a vascular quiescence and endothelial-protective factor, binds sENG with high affinity, but how sENG participates in BMP9 signaling complexes is not fully resolved. sENG was thought to

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Przekora, Agata, and Grażyna Ginalska. "Biological properties of novel chitosan-based composites for medical application as bone substitute." Open Life Sciences 9, no. 6 (2014): 634–41. http://dx.doi.org/10.2478/s11535-014-0297-y.

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AbstractHydroxyapatite is the main inorganic component of bones and teeth. In order to improve mechanical properties and surgical handiness of bioceramics, a plasticizing agent e.g. polysaccharide can be added. Chitosan is a polysaccharide with biological properties that make it an ideal component of bioceramics-based composites for medical application as bone substitute. In this study, biocompatibility of two types of novel krill chitosan-based composites was evaluated. In vitro experiments were carried out using human foetal osteoblast cell line. Cytotoxicity, cell adhesion, and bone ALP act

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Campbell, M. J., E. Elstner, S. Holden, M. Uskokovic, and H. P. Koeffler. "Inhibition of proliferation of prostate cancer cells by a 19-nor-hexafluoride vitamin D3 analogue involves the induction of p21waf1, p27kip1 and E-cadherin." Journal of Molecular Endocrinology 19, no. 1 (1997): 15–27. http://dx.doi.org/10.1677/jme.0.0190015.

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ABSTRACT We have synthesized and studied the ability of a series of seven novel 1α,25(OH)2 vitamin D3 analogues to inhibit clonal growth of prostate cancer cells (LNCaP, PC-3 and DU-145). Addition of double and triple bonds to the C/D ring (C-16) and side chain (C-22 and C-23) as well as lengthening of the side chain were important for enhanced activity against LNCaP and PC-3. Reorientation of the side chain in the 20-epi configuration resulted in analogues that were extremely potent only against LNCaP (ED50 ≈ 5 × 10−11 m). Compounds with six fluorines on the end of the side chain were very ac

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CHAUDHARY, Z. I., M. A. PRICE, and M. MAKARECHIAN. "EFFECTS OF ZERANOL ON WEIGHT GAIN, BONE GROWTH AND OTHER CARCASS TRAITS IN STEERS AND BULLS." Canadian Journal of Animal Science 65, no. 4 (1985): 835–40. http://dx.doi.org/10.4141/cjas85-098.

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The effects of zeranol were studied in 24 steers and 24 bulls starting at an average weight of 200 kg for a trial period of 183 days. Bulls grew faster than steers (P = 0.07) and zeranol-treated cattle showed higher average daily gain than controls (P < 0.05); there was no significant interaction between gender and treatment. Castration increased carcass fatness (P < 0.01) and decreased dressing percent (P < 0.01), rib-eye area (P < 0.01), shank muscle (P < 0.01) and shank muscle:bone ratio (P < 0.01). Implantation with zeranol had no effect on these traits. The weights of th

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