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Dissertations / Theses on the topic 'Bones – Molecular aspects'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 August 2024

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1

Cheng, Tak Sum. "Molecular identification and characterization of novel osteoclast V-ATPase subunits." University of Western Australia. School of Surgery and Pathology, 2008. http://theses.library.uwa.edu.au/adt-WU2008.0068.

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[Truncated abstract] Osteoclasts are multinucleated giant cells responsible for the resorption of the mineralized bone matrix during the process of bone remodelling. During activation towards bone resorption, polarization of the osteoclast results in the formation of a unique plasma membrane, the ruffled border, the actual resorptive organelle of the osteoclast. Through this domain protons are actively pumped into the resorption lacuna creating an acidic microenvironment that favours the dissolution of the mineralized bone matrix. The polarised secretion of protons is carried out by the action

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2

Dai, Zhijie, and 戴志洁. "The role of sodium/myo-inositol cotransporter 1 and myo-inositol in osteogenesis and bone formation." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B43783533.

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3

Chan, Cheuk-wing Wilson, and 陳卓榮. "ER stress in the pathogenesis of osteochondrodysplasia." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B43085192.

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4

Wang, Cathy Ting-Peng. "Molecular dissection of RANKL signaling pathways in osteoclasts." University of Western Australia. School of Surgery and Pathology, 2007. http://theses.library.uwa.edu.au/adt-WU2008.0037.

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[Truncated abstract] Bone remodeling is intricately regulated by osteoclast-mediated bone resorption and osteoblast-mediated bone formation. The elevation in osteoclast number and/or activity is a major hallmark of several common pathological bone disorders including post-menopausal osteoporosis, osteoarthritis, Paget's disease, and tumour-mediated osteolysis. Receptor activator of nuclear factor kappa B ligand (RANKL) is a key cytokine for osteoclast differentiation and activation. The association of RANKL to its cognate receptor, RANK, which is expressed on osteoclast precursors and mature o

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5

Cheng, Yin-wo, and 鄭燕和. "Molecular basis for the increased osteoblast activity in a mouse modelwith hyperostosis." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2005. http://hub.hku.hk/bib/B34612981.

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6

Lee, B. C. Bob, and 李卜駿. "Probing the molecular mechanisms of how polymorphisms in Cerberus-likeresult in low bone mineral density." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B39793771.

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7

Cestari, Tania Mary. "Aspectos celulares, teciduais e moleculares da osteogênese ectópica e ortotópica induzida pela matriz alogênica óssea e dentinária." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/25/25142/tde-02062009-111408/.

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O objetivo do atual trabalho, foi correlacionar os eventos celulares e teciduais com a expressão das proteínas VEGF, BMP-7, RANKL e OPG durante a osteogênese ectópica e ortotópica, induzida pela matriz óssea (MO) e dentinária (MD) alogênica. Matrizes alogênicas desmineralizada em HCl a 0,6N, obtidas de fêmur e incisivo de ratos, fori implantada entre as fáscias musculares da coxa e em defeito trans-ósseo de 8mm de diâmetro nos ossos parietais. As análises radiográfica e histomorfométrica da neoformação óssea e, a imunohistoquímica e o western blotting para as proteínas VEGF, BMP, RANKL e OPG,

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Albuquerque, Dulcinéia Martins de. "Aspectos moleculares do citomegalovirus humano durante infecção ativa em pacientes submetidos ao transplante de medula ossea." [s.n.], 2006. http://repositorio.unicamp.br/jspui/handle/REPOSIP/311935.

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Orientador: Sandra Cecilia Botelho Costa<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas<br>Made available in DSpace on 2018-08-08T16:11:05Z (GMT). No. of bitstreams: 1 Albuquerque_DulcineiaMartinsde_D.pdf: 3473302 bytes, checksum: daa8d0ff76ca0850d748389f7bb2ea56 (MD5) Previous issue date: 2006<br>Resumo: O Citomegalovírus Humano (HCMV) continua sendo uma causa significante de morbidade em pacientes imunocomprometidos, especialmente em transplantados de medula óssea, e pode manifestar diversas complicações que incluem hepatite, doença gastrointestinal

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9

PEREIRA, Andrea de Castro. "Sítios implantáveis da maxila e mandíbula: correlação entre aspectos clínico-radiográficos e histomorfométrico-moleculares." Universidade Federal de Goiás, 2011. http://repositorio.bc.ufg.br/tede/handle/tde/1367.

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Made available in DSpace on 2014-07-29T15:21:57Z (GMT). No. of bitstreams: 1 Dissertacao_AndreaCastroPereira.pdf: 2370466 bytes, checksum: f8365afb8c90d3f08e392b9f49411d3e (MD5) Previous issue date: 2011-03-04<br>The study of bone microarchitecture and its molecular aspects may provide new information for better understanding of "bone quality". Histomorphometry is a recommended reference method for bone-dimensional analysis. At the molecular level, possible changes in the process of resorption and bone formation has not been studied in different patterns of bone "normal." Objective: To analy

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10

Irani, Dilshad Minocher. "Role of the surface associated material of Eikenella corrodens in bone resorption associated with periodontal disease : a research thesis submitted in fulfilment of the requirements for the degree of Master of Science in Dentistry." Title page, contents and summary only, 1998. http://web4.library.adelaide.edu.au/theses/09DSM/09dsmi65.pdf.

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11

Babeto, Erica [UNESP]. "Análise da expressão gênica no tumor ósseo de células gigantes." Universidade Estadual Paulista (UNESP), 2011. http://hdl.handle.net/11449/102755.

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Made available in DSpace on 2014-06-11T19:32:15Z (GMT). No. of bitstreams: 0 Previous issue date: 2011-02-28Bitstream added on 2014-06-13T20:03:28Z : No. of bitstreams: 1 babeto_e_dr_sjrp.pdf: 649918 bytes, checksum: 812ddac8aa99c1d4ba6dfcdc980015a8 (MD5)<br>O tumor ósseo de células gigantes (TCG) é um tumor benigno, que causa destruição osteolítica, com comportamento biológico incerto e com características particulares como um elevado número de células gigantes multinucleadas e comportamento agressivo. A recorrência local do TCG é freqüentemente observada em 20 a 50% dos casos. Mais agravan

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12

Babeto, Erica. "Análise da expressão gênica no tumor ósseo de células gigantes /." São José do Rio Preto : [s.n.], 2011. http://hdl.handle.net/11449/102755.

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Orientador: Paula Rahal<br>Banca: Aparecida Maria Fontes<br>Banca: Débora Aparecida Pires de Campos Zuccari<br>Banca: Ana Elizabete Silva<br>Banca: Jane Lopes Bonilha<br>Resumo: O tumor ósseo de células gigantes (TCG) é um tumor benigno, que causa destruição osteolítica, com comportamento biológico incerto e com características particulares como um elevado número de células gigantes multinucleadas e comportamento agressivo. A recorrência local do TCG é freqüentemente observada em 20 a 50% dos casos. Mais agravante que a recorrência, é o fato de que após a recidiva, o paciente muitas vezes tamb

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13

Tan, Jamie We-Yin. "The investigation of RANKL TNF-like core domain by truncation mutation." University of Western Australia. School of Surgery and Pathology, 2003. http://theses.library.uwa.edu.au/adt-WU2004.0032.

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Osteoclasts are multinucleated cells found exclusively in bone and are derived from the haematopoietic cells of monocytes/macrophage lineage. The cell-to-cell interaction between osteoblastic/stromal cells and osteoclast precursor cells is necessary for osteoclastogenesis. Receptor Activator of NF-κB ligand (RANKL) was identified as a membrane-bound TNF ligand family member that is the ‘master’ cytokine expressed on osteoblastic/stromal cells, which stimulate osteoclastogenesis through cell-to-cell contact with osteoclast precursors. RANKL is considered to be a factor that is necessary and suf

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14

Hamdi, Olfa. "Digestion anaérobie d'effluents d'une conserverie de thon tunisienne : aspects biotechnologiques et microbiologiques." Thesis, Aix-Marseille, 2015. http://www.theses.fr/2015AIXM4711.

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Deux réacteurs, R1 et R2, ont été alimentés quotidiennement avec les effluents à traiter à des TRH de 13 jours et de 20 jours, respectivement. Les résultats obtenus ont montré un taux d'abattement de la dégradation de la matière organique de 53% pour R2, contre 35% pour R1. Afin de mieux comprendre le fonctionnement biologique de ces réacteurs, nous avons exploré les communautés microbiennes d'importance écologique impliquées dans la dégradation de la matière organique contenue dans ces effluents. Cela a été réalisé dans un premier temps par des approches moléculaires en utilisant la technique

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15

Farrow, Emily. "Molecular Genetic Analysis of FGF23 Bioactivity in the Bone-Kidney Endocrine Axis." Thesis, 2009. http://hdl.handle.net/1805/1890.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Heritable disorders of phosphate handling are the most common cause of hypophosphatemic rickets in developed countries. Isolated renal phosphate wasting and subsequent low serum phosphate concentrations may result from a number of genetic disorders that include: autosomal dominant hypophosphatemic rickets (ADHR), X-linked hypophosphatemic rickets (XLH), and autosomal recessive hypophosphatemic rickets (ARHR). Fibroblast growth factor-23 (FGF23), identified as the causative gene in ADHR, is produced in bone and plays a central role in

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16

Anuradha, Valiya Kambrath. "Testing the reliability and selectivity of different bone-cell-specific Cre- expressing mouse models for studying bone cell metabolism." Thesis, 2015. http://hdl.handle.net/1805/7942.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>The Cre/loxP system is a tool for targeted recombination of DNA. For applying Cre recombinase-mediated genome modifications, there is a requirement for reliable, high-fidelity, and specific transgenic expression of the Cre recombinase. This study focuses on the reliability of different bone cell specific Cre models in the Cre/loxP system. In this study, DMP1-Cre transgenic mouse which has a transgene driven by DMP1 promotor that allows Cre-expression only in late stage osteoblasts and osteocytes was used. Ctsk-Cre mouse with a driven

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17

"Roles of CRBP1, N-cadherin and SOX11 in differentiation and migration of bone marrow-derived mesenchymal stem cells." 2012. http://library.cuhk.edu.hk/record=b5549603.

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前言：間充質幹細胞容易擴增並且能分化為成骨細胞、軟骨細胞和脂肪細胞，並且能對炎症、感染和損傷做出反應，並且遷移到相應的組織部位。這些特性使間充質幹細胞成為骨骼組織工程學中非常重要的細胞來源。外周血間充質幹細胞是一種存在於血液中的間充質幹細胞，而主要的間充質幹細胞存在與骨髓中，被稱之為骨髓間充質幹細胞。在我們實驗室之前的研究中通過DNA微陣列發現外周血間充質幹細胞中很多基因的表達與骨髓間充質幹細胞有很大區別。這其中的一些基因可能參與調控間充質幹細胞的分化和歸巢，我們從中挑選了三個變化比較明顯的基因--CRBP1, N-cadherin和 SOX11做進一步研究。本研究的目的在於研究CRBP1, N-cadherin和 SOX11在骨髓間充質幹細胞分化和遷移中的作用及相關機理。<br>方法：培養的骨髓間充質幹細胞來源於6-8周大小的SD大鼠。細胞的表型經過多分化潛能測試（成骨分化，成脂分化和成軟骨分化）和流式細胞儀檢驗。克隆大鼠的CRBP1, N-cadherin和SOX11基因到慢病毒載體。而且還設計了針對CRBP1和 N-cadherin的shRNA及非特異性對照shRNA。慢病毒由暫態轉染293FT細胞產生。細胞遷移實驗採用了BD Falcon的細胞遷移系統（cell culture insert）。實驗採用了定量PCR、免疫共沉澱、western雜交和雙螢光報告檢驗。對於體內實

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18

"Role of Aqp1, Sm51 and GATA6 in differentiation and migration of bone marrow derived mesenchymal stem cells." 2013. http://library.cuhk.edu.hk/record=b5884485.

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Meng, Fanbiao.<br>Thesis (Ph.D.)--Chinese University of Hong Kong, 2013.<br>Includes bibliographical references (leaves 114-138).<br>Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web.<br>Abstract also in Chinese.

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19

"Phenotypic and molecular characterization of mice deficient in protein kinase A regulatory subunit type 1A (prkar1a) and catalytic subunit A (prkaca)." Thesis, 2010. http://library.cuhk.edu.hk/record=b6074857.

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A population of stromal cells that retains osteogenic capacity in adult bone (adult bone stromal cells or aBSCs) exists and is under intense investigation in relation to osteogenesis and relevant pathology. aBSCs may be different from their embryonic or neonatal counterparts, and are influenced by species-/age-specific and other factors. Mice heterozygous for a null allele of prkar1a (Prkar1a+/-, a gene encoding for cyclic adenosine mono-phosphate (cAMP)-dependent regulatory subunit of protein kinase A (PKA), developed bone lesions that resembled fibrous dysplasia (FD) originated from cAMP-re

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20

Zhou, Hongkang. "The essential role of Stat3 in bone homeostasis and mechanotransduction." Thesis, 2014. http://hdl.handle.net/1805/6190.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Signal Transducer and Activator of Transcription 3 (Stat3) is a transcription factor expressed in bone and joint cells that include osteoblasts, osteocytes, osteoclasts, and chondrocytes. Stat3 is activated by a variety of cytokines and growth factors, including IL-6/gp130 family cytokines. These cytokines not only regulate the differentiation of osteoblasts and osteoclasts, but also regulate proliferation of chondrocytes through Stat3 activation. In 2007, mutations of Stat3 have been confirmed to cause a rare human immunodeficiency

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21

Rhodes, Steven David. "Dissecting the cellular and molecular mechanisms mediating neurofibromatosis type 1 related bone defects." Thesis, 2014. http://hdl.handle.net/1805/3793.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Skeletal manifestations including short stature, osteoporosis, kyphoscoliosis, and tibial dysplasia cumulatively affect approximately 70% of patients with neurofibromatosis type 1 (NF1). Tibial pseudarthrosis, the chronic non-union of a spontaneous fracture, is a debilitating skeletal malady affecting young children with NF1. These non-healing fractures respond poorly to treatment and often require amputation of the affected limb due to limited understanding of the causative mechanisms. To better understand the cellular and molecula

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22

Hum, Julia M. "Signaling mechanisms that suppress the anabolic response of osteoblasts and osteocytes to fluid shear stress." Thesis, 2014. http://hdl.handle.net/1805/4652.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Bone is a dynamic organ that responds to its external environment. Cell signaling cascades are initiated within bone cells when changes in mechanical loading occur. To describe these molecular signaling networks that sense a mechanical signal and convert it into a transcriptional response, we proposed the mechanosome model. “GO” and “STOP” mechansomes contain an adhesion-associated protein and a nucleocytoplasmic shuttling transcription factor. “GO” mechanosomes functions to promote the anabolic response of bone to mechanical load

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23

"Bone marrow-derived macrophage myofibroblast transition (MMT) in renal fibrosis." 2012. http://library.cuhk.edu.hk/record=b5549424.

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背景：纤维化是各种因素导致肾脏慢性损伤的最终病理过程，是决定肾功能转归的关键因素。肌纤维母细胞作为构成肾脏纤维化组织的主要细胞成分，其来源尚不清楚。本研究认为骨髓来源的巨噬细胞向肌纤维母细胞转分化（MMT）可能是肾脏纤维化中肌纤维母细胞的主要来源。我们分别在慢性肾脏病患者的肾活检组织和小鼠单侧输料管梗阻模型（UUO）中验证这一假说。<br>方法：我们用激光共聚焦技术和流式细胞染色的方法检测小鼠UUO肾脏和患者肾活检组织中的MMT细胞(F4/80⁺α-SMA⁺或CD68⁺α-SMA⁺)。为了验证骨髓来源的MMT在肾纤维化中的重要作用，UUO模型分别在以下小鼠进行：1）去除骨髓的C57BL/6J小鼠，给予或不给予绿色荧光蛋白（GFP）标记的骨髓细胞移植；2）GFP⁺骨髓的嵌合体小鼠；3）巨噬细胞敲除或不敲除的lysM-Cre/DTR小鼠；4）GFP⁺Smad3⁺/⁺ 或GFP⁺Smad3⁻/⁻骨髓的嵌合体小鼠。我们用实时定量PCR和Western blot检测小鼠肾组织collagen-I和α-SMA水平。另外，我们观察MMT细胞和PDGFR-β⁺ pericytes, CD45⁺collagen I⁺ fibrocytes的关系。最后，通过观察GFP⁺Smad3⁻/⁻骨髓嵌合体小鼠UUO模型肾纤维化程度和TGF-β1刺激下TGF-β受体II或Smad3敲除的骨髓巨噬细胞MMT的不同进

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24

Dumaual, Carmen Michelle. "Expression and Function of the PRL Family of Protein Tyrosine Phosphatase." 2013. http://hdl.handle.net/1805/3248.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>The PRL family of enzymes constitutes a unique class of protein tyrosine phosphatase, consisting of three highly homologous members (PRL-1, PRL-2, and PRL-3). Family member PRL-3 is highly expressed in a number of tumor types and has recently gained much interest as a potential prognostic indicator of increased disease aggressiveness and poor clinical outcome for multiple human cancers. PRL-1 and PRL-2 are also known to promote a malignant phenotype in vitro, however, prior to the present study, little was known about their express

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Tanataweethum, Nida. "Mechanical property and biocompatibility of PLLA coated DCPD composite scaffolds." Thesis, 2014. http://hdl.handle.net/1805/4448.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Dicalcium phosphate dihydrate (DCPD) cements have been used for bone repair due to its excellent biocompatibility and resorbability. However, DCPD cements are typically weak and brittle. To overcome these limitations, the sodium citrate used as a setting regulator and the coating of poly-L-lactide acid (PLLA) technique have been proposed in this study. The first purpose of this thesis is to develop composite PLLA/DCPD scaffolds with enhanced toughness by PLLA coating. The second purpose is to examine the biocompatibility of the scaf

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Martin, Holly René. "Mechanism of Transformation and Therapeutic Targets for Hematological Neoplasms Harboring Oncogenic KIT Mutation." Thesis, 2014. http://hdl.handle.net/1805/5503.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Gain-of-function mutations in the KIT receptor tyrosine kinase have been associated with highly malignant human neoplasms. In particular, an acquired somatic mutation at codon 816 in the second catalytic domain of KIT involving an aspartic acid to valine substitution is found in patients with systemic mastocytosis (SM) and acute myeloid leukemia (AML). The presence of this mutation in SM and AML is associated with poor prognosis and overall survival. This mutation changes the conformation of the KIT receptor resulting in altered subs

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