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Journal articles on the topic 'Boonei'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Akinmurele, Opeyemi Josephine, Mubo Adeola Sonibare, Anthony A. Elujoba, et al. "Antispasmodic Effect of Alstonia boonei De Wild. and Its Constituents: Ex Vivo and In Silico Approaches." Molecules 28, no. 20 (2023): 7069. http://dx.doi.org/10.3390/molecules28207069.

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Background: Alstonia boonei, belonging to the family Apocynaceae, is one of the best-known medicinal plants in Africa and Asia. Stem back preparations are traditionally used as muscle relaxants. This study investigated the antispasmodic properties of Alstonia boonei Stem back and its constituents. Method: The freeze-dried aqueous Stem back extract of A. boonei, as well as dichloromethane (DCM), ethyl acetate, and aqueous fractions, were evaluated for their antispasmodic effect via the ex vivo method. Two compounds were isolated from the DCM fraction using chromatographic techniques, and their

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2

Osagie, O. A., U. Igbinogun, O. J. Okoh, and K. Oriakhi. "Phytochemical Composition, In vitro Antioxidant and Antimicrobial Activities of Methanol extract of Cheese Wood (Alstonia boonei) Leaves collected from Benin City, Nigeria." Journal of Applied Sciences and Environmental Management 27, no. 10 (2023): 2283–89. http://dx.doi.org/10.4314/jasem.v27i10.20.

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The Cheese wood (Alstonia boonei) tree, known as Egbu-ora in Igbo, Ahun in Yoruba, Ukpukunu in Urhobo and Ukhu in Edo, is a widely distributed plant in the lowlands and rain-forest areas of Nigeria. It has been listed in the African Pharmacopoeia as an antimalarial drug and a traditional medicine for the treatment of fever, painful micturition, insomnia, chronic diarrhoea, and rheumatic pains as antivenom for snake bites and in the treatment of arrow poisoning. This work aims to investigate the phytochemical composition, in vitro antioxidant, and antimicrobial activities of methanol extract of

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3

C Onyishi, Grace, Godwin C Nwosu, and Joseph E Eyo. "In vivo studies on the biochemical indices of Plasmodium berghei infected mice treated with Alstonia boonei leaf and root extracts." African Health Sciences 20, no. 4 (2020): 1698–709. http://dx.doi.org/10.4314/ahs.v20i4.21.

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Background: A study on the biochemical indices of albino mice infected with Plasmodium berghei and treated with Alstonia boonei aqueous and ethanolic extracts was undertaken. Methods: 216 males mice were randomly assigned to six treatment groups each containing six mice for both aqueous and ethanolic extracts experiments. P. berghei NK-65 was inoculated into the mice intraperitoneally and establishment of infection confirmed. Administration of extracts of was done after phytochemical and acute toxicity tests at varying concentrations, for both suppressive and curative tests. Blood sample

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4

Robert, I. Uroko, E. Okpashi Victor, P.R. Bayim Bayim, U. Onwuekwe Anthony, M. Ucho Kate, and Wallace Igori. "Dietary effect of Alstonia Boonei stem bark extract on hematological profiles of Wistar albino rats after inducing oxidative stress with CCl4." African Journal of Biological Sciences 2, no. 4 (2020): 45–56. https://doi.org/10.33472/AFJBS.2.4.2020.45-56.

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This study examined the dietary outcome of <em>Alstonia boonei</em> stem bark.<em> A. boonei</em> stem bark was extracted with ethanol after air-drying and grinding. Hematological indices of Wistar albino rats were impacted with carbon tetrachloride (CCl<sub>4</sub>). Eighteen male albino mice were used to check acute toxicity of the extract while 30 albino rats were used to examine the hematological functions – Packed cell volume (PCV), hemoglobin (Hb) concentration, total white blood cell (WBC) count, total red blood cell (RBC) count and platelet count. The rats were separated into six

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5

Afrifah, Kojo Agyapong, and Enoch Adjei-Mensah. "Anatomical and chemical characterization of Alstonia boonei for pulp and paper production." Les/Wood 70, no. 2 (2021): 5–18. http://dx.doi.org/10.26614/les-wood.2021.v70n02a02.

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Alstonia boonei, an abundant lesser utilized species within the West African Subregion, was evaluated as an alternative raw material for pulp and paper production. The basic density (BD), fibre characteristics [fibre length (FL), fibre diameter (FD), lumen diameter (LD) and wall thickness (WT)], derived anatomical indices [Flexibility Ratio (FR), Slenderness Ratio (SR), Rigidity Coefficient (RC), Luce’s Shape Factor (LSF), Solids Factor (SF) and Runkel Ratio (RR)] and chemical composition (lignin, holocellulose, 1% NaOH solubility and ash contents) of A. boonei were studied to evaluate variati

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6

Kinjouo, Ghislain Kenguem, Marie Caroline Momo Solefack, and Victor François Nguetsop. "Macroscopic and Microscopic Modifications of Wood after Debarking of Trees in the South Cameroon." Journal of Plant Studies 10, no. 1 (2021): 30. http://dx.doi.org/10.5539/jps.v10n1p30.

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Wounding of trees by debarking has been reported to form a callus tissue. This work aims to investigate macroscopic and microscopic modifications of wood after the removal of barks in Alstonia boonei, Scorodophloeus zenkeri, and Garcinia lucida. Species that are not yet barking were wounded to conducting experimental debarking. The wound was rectangular with 30 cm vertically with a lateral extent of 10 cm. Every three months, there was a follow-up for fifteen months during which the macroscopic and microscopic phenomena were observed and recorded. Microsections of 15&ndash;20 &mu;m thi

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7

Mollica, Adriano, Gokhan Zengin, Kouadio Ibrahime Sinan, et al. "A Study on Chemical Characterization and Biological Abilities of Alstonia boonei Extracts Obtained by Different Techniques." Antioxidants 11, no. 11 (2022): 2171. http://dx.doi.org/10.3390/antiox11112171.

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In the quest for novel therapeutic agents from plants, the choice of extraction solvent and technique plays a key role. In this study, the possible differences in the phytochemical profile and bioactivity (antioxidant and enzyme inhibitory activity) of the Alstonia boonei leaves and stem bark extracted using water, ethyl acetate and methanol, and different techniques, namely infusion, maceration and Soxhlet extraction, were investigated. Data collected showed that methanol extracts of both A. boonei leaves (48.34–53.08 mg gallic acid equivalent [GAE]/g dry extract) and stem bark (37.08–45.72 m

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8

Ileke, Kayode David, and Arotolu Temitope Emmanuel. "Bioefficacy of Alstonia boonei leaf extract against cowpea beetle Callosobrochus maculatus infesting stored cowpea seeds in storage." Brazilian Journal of Biological Sciences 5, no. 11 (2018): 673–81. http://dx.doi.org/10.21472/bjbs.051106.

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This study was conducted to investigate the efficacy of the oils of Alstonia boonei leaf extracted with n-hexane, petroleum ether, methane and acetone as contact insecticides against the activities of Callosobrochus maculatus in stored cowpea seed. The oils were incorporated at rates 2.0 mL per 20 g of cowpea seeds. The parameters assessed include, mortality of adult insects, oviposition and adult emergence to ascertain the control of the beetle. All concentration of the extracts used evoked 100% mortality of C. maculatus after 72 h of post treatment. The development of Callosobrochus maculatu

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9

Akinboro, A., M. A. Rufai, R. A. Adeagbo, et al. "Evaluation of an Antimalarial Herbal Recipe and its Individual Plant Extracts for DNA Fragmentation and Clastogenicity Potential in Swiss Albino Mice." Nigerian Journal of Basic and Applied Sciences 29, no. 2 (2022): 89–101. http://dx.doi.org/10.4314/njbas.v29i2.9.

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In this study, water extracts of leaves of Azadirachta indica and stem bark of Alstonia boonei, and their recipe were evaluated at 25.0%, 50.0% and 100.0% following DNA fragmentation and micronucleus assays in Swiss albino mice. Distilled water and 0.05% sodium azide served as negative and positive controls, respectively. The levels of superoxide dismutase, catalase and malondialdehyde in the treated mice were determined. The FTIR technique was adopted to identify the functional groups of phytochemicals present, and the proximate constituents were also determined. The individual extracts of A.

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10

Zali, Marielle Anastasie, Martin Fonkoua, Charles Dakole Daboy, et al. "Comparative Study of the Effect of Two Extraction Solvents on Polyphenols Content and Antioxidant Activity of Alstonia Boonei Bark." Asian Journal of Chemical Sciences 13, no. 4 (2023): 7–17. http://dx.doi.org/10.9734/ajocs/2023/v13i4245.

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Oxidative stress (OS) is the imbalance between the generation of reactive oxygen species (ROS) and the body's antioxidant defenses in favor of ROS. ROS are chemical species that can be neutralized by natural phytochemicals like phenolic compounds present in medicinal plants and whose extraction depends on the solvent system used. Thus, the present study aimed to evaluate the effect of two extraction solvents on the polyphenols content and antioxidant activity of Alstonia boonei barks. For this, the bark of A. boonei were harvested, processed, dried and ground, then the powder was macerated in

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11

Adotey, John Prosper Kwaku, Genevieve Etornam Adukpo, Yaw Opoku Boahen, and Frederick Ato Armah. "A Review of the Ethnobotany and Pharmacological Importance of Alstonia boonei De Wild (Apocynaceae)." ISRN Pharmacology 2012 (July 30, 2012): 1–9. http://dx.doi.org/10.5402/2012/587160.

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Alstonia boonei De Wild is a herbal medicinal plant of West African origin, popularly known as God's tree or “Onyame dua”. Within West Africa, it is considered as sacred in some forest communities; consequently the plant parts are not eaten. The plant parts have been traditionally used for its antimalarial, aphrodisiac, antidiabetic, antimicrobial, and antipyretic activities, which have also been proved scientifically. The plant parts are rich in various bioactive compounds such as echitamidine, Nα-formylechitamidine, boonein, loganin, lupeol, ursolic acid, and β-amyrin among which the alkaloi

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12

Oyeniyi, Emmanuel Ayobami. "Assessment of powders of Alstonia boonei (De wild) and Acalypha godseffienna (Muell Arg.) as protectants of rice grains against infestation by Sitotroga cerealella (Olivier, 1789) (Lepidoptera: Gelechiidae)." Brazilian Journal of Biological Sciences 5, no. 10 (2018): 489–97. http://dx.doi.org/10.21472/bjbs.051025.

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In this study, the mothcidal efficacy of powders of Alstonia boonei (De Wild) stem bark and Acalypha godseffienna (Muell Arg.) leaf part was investigated at ambient temperature (28 +/- 3 oC) and relative humidity (75% +/- 6%). Adult Sitotroga cerealella were exposed to both botanical powders using contact toxicity test at 1-5 g/20 g of paddy rice and mortality was assessed after 24, 48, 72 and 96 h post-treatment, respectively. The control experiment was also set-up for each botanical. Generally, both botanical powders significantly (P < 0.05) evoked higher moth mortality when compared to c

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13

Izum, Mary Chinenye, and Stella Oghomwen Olubodun. "Comparative Analysis of Phytochemical Constituents and Antioxidant Properties of Aqueous and Ethanol Extracts of Alstonia boonei Stem-Bark." Bioscientist Journal 1, no. 3 (2023): 231–41. http://dx.doi.org/10.54117/the_bioscientist.v11i3.157.

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The plant Alstonia boonei is extensively used in traditional medicine because of its therapeutic properties. Over the years, researchers have been looking for the active medicinal agents in different plant species and as such, the type of extraction solvent plays a major role. This study aim to investigate the comparative analysis of phytochemical constituents and antioxidant properties of aqueous and ethanol extracts of A. boonei stem-bark. The stem-bark of A. boonei was collected, dried, pulverized and extracted with ethanol and distilled water using maceration method. The extract was concen

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14

Otuu, C. A., H. Usman-Yamman, I. C. Ekuma, et al. "Analysis, characterization and malaria parasitaemia suppression potential of bioactive compounds from aqueous extracts of a medicinal plant used for the traditional treatment of malaria in African countries." World Journal of Applied Science & Technology 16, no. 1 (2025): 51–56. https://doi.org/10.4314/wojast.v16i1.51.

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The properties exhibited by a plant, including the medicinal ones, is attributed to the type and nature of the bioactive compounds that are present in the plant. Thus the study of such bioactive compounds is very key in any medicinal studies of the plant. This study was carried out to analyze, characterize and evaluate the malaria parasitaemia suppression potential of the bioactive compounds of aqueous leaf, stem bark and root extracts of Alstonia boonei, a pan African medicinal plant, and position it for potential new antimalarial drug development. The extracts were subjected to Gas Chromatog

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15

Atanu, Francis O., Favour M. Idih, Charles O. Nwonuma, Helal F. Hetta, Salman Alamery, and Gaber El-Saber Batiha. "Evaluation of Antimalarial Potential of Extracts from Alstonia boonei and Carica papaya in Plasmodium berghei-Infected Mice." Evidence-Based Complementary and Alternative Medicine 2021 (October 6, 2021): 1–11. http://dx.doi.org/10.1155/2021/2599191.

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Extracts of Alstonia boonei and Carica papaya are used in herbal medicine for the treatment of malaria. This work investigated the phytochemical, antioxidant, and antimalarial effects of hydromethanolic extracts of Alstonia boonei and Carica papaya. A four-day chemosuppressive test was conducted to assess the ability of the extracts to prevent establishment of infection. Three doses of the extracts were administered—100, 200, and 400 mg/kg bw—prior to Plasmodium berghei challenge. Change in body weight, parasitemia, packed cell volume (PCV), and mean survival time was determined. A three-day c

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16

Akeem, Akinboro, Rufai Muhamed Akinlabi, Ogunbameru Aanuoluwapo Dorcas, Oladosu Bolaji Esther, and Taiwo Modinat Opeyemi. "Evaluation of an antimalarial herbal mixture and each extract for DNA and chromosomal mutations in Swiss albino mice and Allium cepa cells." Asian Journal of Medical and Biological Research 7, no. 3 (2021): 249–59. http://dx.doi.org/10.3329/ajmbr.v7i3.56135.

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Toxicological evaluation of herbal medicines is necessary because of possible adverse effects that may be associated with their consumption. This study screened antimalarial herbal recipe (containing leaves of Azadirachta indica and stem-bark of Alstonia boonei) and its individual plant’s extract for DNA and chromosomes mutation potentials following the DNA fragmentation and Allium cepa assays. Superoxide dismutase (SOD), catalase (CAT) and malondialdehyde (MDA) activity of the recipe and each extract was determined. The kinds of phytochemicals present in them were determined using the FTIR te

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17

Adjouzem, Carine Flore, Ateufack Gilbert, Marius Mbiantcha, et al. "Effects of Aqueous and Methanolic Extracts of Stem Bark of Alstonia boonei De Wild. (Apocynaceae) on Dextran Sodium Sulfate-Induced Ulcerative Colitis in Wistar Rats." Evidence-Based Complementary and Alternative Medicine 2020 (May 30, 2020): 1–15. http://dx.doi.org/10.1155/2020/4918453.

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Among the most exploited species in Cameroon, Alstonia boonei is widely used in African medicine for the relief of several pathologies including gastrointestinal disorders. This study was conducted in order to assess the effects of aqueous and methanol stem-bark extracts of Alstonia boonei on DSS- (dextran sodium sulfate-) induced intestinal colitis and to determine its antioxidant potential. The classes of secondary metabolites present in these extracts were determined by chemical screening. The production of TNF-α, IL-6, IL-1β, and PGE2 was performed by in vitro ELISA analysis. Anticolitis e

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Balogun, Olaoye S., Olukayode S. Ajayi, and Bukola J. Agberotimi. "A Cytotoxic Indole Alkaloid from Alstonia boonei." Journal of Biologically Active Products from Nature 6, no. 4 (2016): 347–51. http://dx.doi.org/10.1080/22311866.2016.1250676.

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19

Irulandi, Kokkaiah, Sethupandian Geetha, and Palanichamy Mehalingam. "ANTIMICROBIAL ACTIVITY OF SELECTED INDIAN FOLK MEDICINAL PLANTS: MYRISTICA FATUA, ALSTONIA BOONEI, HELICTERES ISORA, VITEX ALTISSIMA AND ATALANTIA RACEMOSA." Asian Journal of Pharmaceutical and Clinical Research 10, no. 2 (2017): 277. http://dx.doi.org/10.22159/ajpcr.2017.v10i2.15572.

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Objective: To determine antimicrobial activity of methanol, ethyl acetate and acetone extracts of Myristica fatua, Alstonia boonei, Helicteres isora, Vitex altissima and Atalantia racemosa against different species of pathogens, Streptococcus feacalis, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Bacillus subtilis, Staphyllococcus aureus, and Candida albicans.Methods: Antimicrobial activity of plant extracts was measured by agar well diffusion method.Results: Acetone extracts of Alstonia boonei showed the highest inhibitory effect against Escherichia coli (21.00 ± 1.00 mm)

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Kenguem, Kinjouo Ghislain, Victor François Nguetsop, and Solefack Marie Caroline Momo. "Utilisation ethnobotanique de Garcinia lucida, Scorodophloeus zenkeri et Alstonia boonei dans la localité de Ngovayang I (Sud Cameroun)." Cameroon Journal of Experimental Biology 14, no. 2 (2021): 16–23. http://dx.doi.org/10.4314/cajeb.v14i2.4.

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Les forêts d’Afrique centrale contiennent plusieurs produits d’origine animale et végétale. Les produits d’origine végétale peuvent se distinguer en produits forestiers ligneux et non ligneux. Le présent travail de recherche porte sur l’importance et la gestion durable de quelques Produits Forestiers Non Ligneux (PFNL), notamment l’écorce de trois arbres (Garcinia lucida, Scorodophloeus zenkeri, Alstonia boonei) dans la localité de Ngovayang I. À l’aide d’un questionnaire semi-structuré, les caractéristiques du secteur des PFNL, les stratégies de gestion, ainsi que l’impact de la valorisation

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21

Gbaye, Olajire Ayodele, Emmanuel Ayobami Oyeniyi, and Janet Titilayo Eweniyi. "Mothcidal activity of three botanical extracts against Sitotroga cerealella (Olivier, 1789) (Lepidoptera: Gelechiidae) infesting rice grains." Brazilian Journal of Biological Sciences 3, no. 6 (2016): 367–74. http://dx.doi.org/10.21472/bjbs.030612.

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The renewed awareness on the potential adverse effects associated with several synthetic insecticides has continually served as impetus to search for safer and more sustainable pesticides derived from plant origin. In this study, the mothcidal activity of Alstonia boonei (de wild), Garcinia kola (Heckel) and Crassocephalum crepidoides (Benth) against Sitotroga cerealella (Olivier, 1789) was investigated at ambient temperature (28 +/- 2 oC) and relative humidity (75% +/- 5%). Adult moths were exposed to 1%, 2% and 3% concentration of each oil extract and mortality was recorded at day 1, 2, 3, 4

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22

Irenee Kue, Messanh Delagnon, Yendube Tougueligh, Sabrina Chris Janiba San, et al. "Effect of Alstonia boonei (Apocynaceae) on Blood Coagulation." Journal of Pharmacology and Toxicology 17, no. 2 (2022): 73–80. http://dx.doi.org/10.3923/jpt.2022.73.80.

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23

Chukwu, C. N., R. I. Uroko, S. I. Egba, F. A. Adamude, and C. L. Asadu. "Effects of Combined Ethanol Extract of Anthocleista Vogelii and Alstonia Boonei Stem Barks on Liver Function Indices in Benign Prostatic Hyperplasia Induced." Nigerian Journal of Pharmaceutical Research 16, no. 2 (2021): 191–201. http://dx.doi.org/10.4314/njpr.v16i2.10.

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Objective: This study evaluated the effects of combined ethanol extract of Anthocleista vogelii and Alstonia boonei (CEAA) stem barks on the liver function indices of benign prostatic hyperplasia (BPH)-induced rats.Materials and Methods: Thirty (30) male Wistar rats were randomly grouped into five groups (n = 6). BPH was induced subcutaneously with 5 mg/kg/day of testosterone propionate in olive oil. Groups 1-3 served as normal, BPH control (untreated) and standard drug control respectively, while Groups 4 and 5 were BPH-induced rats and treated with 200 and 400 mg/kg/day of the CEAA respectiv

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Glalah, Mark, Charles Antwi-Boasiako, and Derrick Adu-Gyamfi. "Binder-type effect on the physico-mechanical, combustion and emission properties of Alstonia boonei De Wild. sawdust and Theobroma cacao L. pod biochar briquettes for energy applications." PLOS ONE 19, no. 7 (2024): e0306827. http://dx.doi.org/10.1371/journal.pone.0306827.

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Energy application potential from the abundant biomass residues is inadequately exploited. Over-dependence on forest trees, its negative environmental impacts, and ever-rising energy costs require alternative production technologies including briquetting. The physico-mechanical and combustion properties of binderless and bindered Alstonia boonei sawdust and Theobroma cacao (cocoa) pod briquettes, carbonized in a steel kiln (at 410±5°C, and a heating rate of 4°C/min from the ambient temperature of 25°C), piston-pressed at 9.0 MPa, were studied. The binders were starch, wax, and clay. Starch-bin

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Ambomo, Nadine Florence, Raceline Kamkumo Gounoue, Jean Hubert Donfack, et al. "Aqueous extract of Alstonia boonei De Wild (Apocynaceae) alleviates bone metabolism disorders induced by oxidised palm oil and sucrose supplementation in rats." Journal of Phytopharmacology 13, no. 3 (2024): 197–207. http://dx.doi.org/10.31254/phyto.2024.13302.

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Background: Poor nutritional status disrupts bone metabolism leading to fractures. This study investigated the effect of the aqueous leaf extract of Alstonia boonei on fractured rats fed a diet supplemented with oxidised palm oil and sucrose. Methods: The iodine, peroxide and acidity indexes of the oxidised palm oil were determined. Bone damage was induced by feeding rats an oxidised palm oil/sucrose enriched diet for 16 weeks followed by fracture. Fractured animals received distilled water or plant extract (50, 100 or 200 mg/kg) simultaneously with their diet for two weeks. Biochemical parame

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Taiwo, J. E., U. B. Shemishere, and E. S. Omoregie. "Assessment of hepatoprotective effect of extracts of Alstonia boonei leaf in isoniazid and rifampicin co-treated rats." World Journal of Biomedicine and Pharmaceutical Sciences 3 (June 12, 2019): 1–6. https://doi.org/10.5281/zenodo.3243894.

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Anti-tuberculosis drugs, rifampicin and isoniazid, in their mode of action can generate toxic reactive metabolites upon oxidative bio-activation of the parent compound by the cytochrome P<sub>450 </sub>monooxygenase system leading to liver injury. Currently, there is increased awareness of the benefits in the use of medicinal plants in the management of various oxidative stress-related diseases. This study therefore evaluated the hepatoprotective effect of aqueous and ethanol extracts of <em>Alstonia boonei </em>leaf in rats co-treated with isoniazid (INH) and rifampicin (RIF). Sets of albino

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Bräuer, Suzanna L., Hinsby Cadillo-Quiroz, Rebekah J. Ward, Joseph B. Yavitt, and Stephen H. Zinder. "Methanoregula boonei gen. nov., sp. nov., an acidiphilic methanogen isolated from an acidic peat bog." International Journal of Systematic and Evolutionary Microbiology 61, no. 1 (2011): 45–52. http://dx.doi.org/10.1099/ijs.0.021782-0.

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A novel acidiphilic, hydrogenotrophic methanogen, designated strain 6A8T, was isolated from an acidic (pH 4.0–4.5) and ombrotrophic (rain-fed) bog located near Ithaca, NY, USA. Cultures were dimorphic, containing thin rods (0.2–0.3 μm in diameter and 0.8–3.0 μm long) and irregular cocci (0.2–0.8 μm in diameter). The culture utilized H2/CO2 to produce methane but did not utilize formate, acetate, methanol, ethanol, 2-propanol, butanol or trimethylamine. Optimal growth conditions were near pH 5.1 and 35 °C. The culture grew in basal medium containing as little as 0.43 mM Na+ and growth was inhib

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OKPO, S. O., L. O. INIAGHE, and J. O. AIGBEDE. "ANTIINFLAMMATORY ACTIVITY OF THE METHANOLIC LEAF EXTRACT OF Alstonia boonei." Nigerian Journal of Life Sciences (ISSN: 2276-7029) 2, no. 1 (2012): 15–20. http://dx.doi.org/10.52417/njls.v2i1.62.

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The leaves of Alstonia boonei are generally used in some parts of Africa in the treatment of inflammatory disorders and other minor illnesses. The anti-inflammatory activity of the methanolic leaf extract of Alstonia boonei was evaluated using three acute models of inflammation, namely; carrageenan-induced and dextran-induced rat paw oedema and croton oil-induced ear oedema in mice. The extract (100-400mg/kg body weight) produced significant (p<0.05) inhibitions of the carrageenan and dextran-induced rat paw oedema. The extract also caused a significant (p<0.05) inhibition of the croton

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Assam Assam, Jean Paul, Marc Flaubert Yumsu Tcham, Ndedi Esther Del Florence Moni, Diboue Patrick Hervé Betote, Tchinda Cedric Fossi, and Beng Veronique Penlap. "Phytochemical screening, Antimycobacterial activity of three medicinal Cameroonians plants and Acute toxicity of hydroethanolic extract of Vitellaria paradoxa." Journal of Drug Delivery and Therapeutics 10, no. 1-s (2020): 96–104. http://dx.doi.org/10.22270/jddt.v10i1-s.3848.

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Tuberculosis (TB) is an infectious disease caused by the Mycobacterium tuberculosis (M. tuberculosis) complex, resposible for health problems in developing countries. In Africa, various medicinal plants are traditionally used to treat TB. The aim of this study is to carry out the phytochemical screening, to evaluate the antimycobacterial activity of the crude extracts of three medicinal plants present in Cameroon (Zingiber officinale, Vitellaria paradoxa and Alstonia boonei) and the acute toxicity of hydroethanolic extract of Vitellaria paradoxa. The phytochemical screening was obtained by hyd

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Adukpo, Selorme, Doris Elewosi, Richard Harry Asmah, et al. "Antiplasmodial and Genotoxic Study of Selected Ghanaian Medicinal Plants." Evidence-Based Complementary and Alternative Medicine 2020 (September 23, 2020): 1–10. http://dx.doi.org/10.1155/2020/1582724.

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Ethnopharmacological Relevance. Development of resistance to antimalarial drugs by Plasmodium falciparum is still rampant, and there is an urgent need for novel drugs to either standalone or to partner artemisinin for treatment of malaria. Traditionally, plants have, over the years, been a good source of antimalarial drugs. Efficacy and safety of such plants need to be scientifically authenticated. Aims, Materials, and Method. This study investigated the in vitro antiplasmodial activity, cytotoxicity, and genotoxicity of aqueous extracts of Acanthospermum hispidum DC, Alstonia boone (De Wild),

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Ajayi, CO, AA Elujoba, and AO Adepiti. "Antiplasmodial Properties of Alstonia boonei Stem-Bark and Picralima nitida Seed in Different Combinations." Nigerian Journal of Natural Products and Medicine 19 (August 28, 2015): 71–77. http://dx.doi.org/10.4314/njnpm.v19i0.7.

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The use of mixtures of plants in form of decoctions is common practice in African ethnomedicine.The study evaluated the antiplasmodial activities of the freeze-dried decoctions of different combination ratios of the stem-bark of Alstonia boonei De Wild (Apocynaceae) and dry seed of Picralima nitida (Stapf) T.&H.Dur. (Apocynaceae) against chloroquine-sensitive Plasmodium bergheiberghei NK65 strain.Thus, the decoctions of the mixtures of A. boonei stem-bark (A) and P. nitida seed (P) were prepared in three different ratios 1:1 (AP1), 1:2 (AP2) and 2:1 (AP3), were separately filtered, concent

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Onefeli, Alfred O., and Lekan P. Kehinde. "Taxonomic Value of Leaf Epidermal Markers in Discriminating Some Medicinal Tree Species of Apocynaceae Juss." Environmental Sciences Proceedings 3, no. 1 (2020): 91. http://dx.doi.org/10.3390/iecf2020-07982.

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Apocynaceae is a useful family comprising trees notable for different medicinal remedies. Consequent to their importance vis-à-vis scarcity in the forest, they are being sold in various Nigerian markets by herb sellers mostly in sterile and fragmentary forms. Hence, the medicinal plants are subjected to adulteration and substitution. Frequently, identification of the plants by users is basically with the aid of floristic markers, which are not readily available for such purpose. It, therefore, becomes pertinent to carry out the taxonomic revision of these trees to provide additional markers th

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Amanfo, Adwoa Frema, Samuel Kyei, Yaw Duah Boakye, et al. "The Aqueous Stem Bark Extract of Alstonia boonei Exhibits Anticataract Activity in Sprague Dawley Rat." Scientifica 2023 (August 1, 2023): 1–12. http://dx.doi.org/10.1155/2023/5524137.

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In Africa, Alstonia boonei is used folklorically for the management of the multitude of conditions including cataract, which accounts for 50% of cases of blindness in the region. The current study set out to probe the traditional use of the aqueous extract of Alstonia boonei stem bark (ABE) as an anticataract remedy using Sprague Dawley rat models. We investigated the probable phytochemical constituents in the extract, in vitro antioxidant potential, and its in vitro aldose reductase inhibition. For the anticataract investigations, diabetic cataract was induced using galactose in 3-week-old Sp

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Akinloye, O., and R. Oshilaja. "Hypoglyceamic activity of Alstonia boonei stem bark extract in mice." Agriculture and Biology Journal of North America 4, no. 1 (2013): 1–5. http://dx.doi.org/10.5251/abjna.2013.4.1.1.5.

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Béguin, Pierre, Yankel Chekli, Guennadi Sezonov, Patrick Forterre, and Mart Krupovic. "Sequence motifs recognized by the casposon integrase of Aciduliprofundum boonei." Nucleic Acids Research 47, no. 12 (2019): 6386–95. http://dx.doi.org/10.1093/nar/gkz447.

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Abstract Casposons are a group of bacterial and archaeal DNA transposons encoding a specific integrase, termed casposase, which is homologous to the Cas1 enzyme responsible for the integration of new spacers into CRISPR loci. Here, we characterized the sequence motifs recognized by the casposase from a thermophilic archaeon Aciduliprofundum boonei. We identified a stretch of residues, located in the leader region upstream of the actual integration site, whose deletion or mutagenesis impaired the concerted integration reaction. However, deletions of two-thirds of the target site were fully func

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Abdulrahaman, Alanamu Abdullahi, Abdulaziz Abdullah Al Sahli, Abimbola Aluko Tinuola, Sunday Adebunmi Adeniran, and Abdulquadri Sagaya. "The use of microstructures in the authentication of powdered drug plants." Bio-Research 19, no. 2 (2021): 1297–305. http://dx.doi.org/10.4314/br.v19i2.3.

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Adulteration and substitution of herbal drugs are trending issues in the herbal industry, posing a serious threat to commercial natural product research. The anatomy of powdered and non-powdered samples of plant species were compared to ascertain their similarities. Air dried powdered leaf samples and unground or intact leaves, flowers and barks of eight medicinal plant species, namely, Vernonia amygdalina, Ocimum gratisimum, Trichilia monadelpha, Bridelia ferruginea, Lophira alata., Alstonia boonei, Dialium guineense and Enantia chlorantha were studied anatomically with the aim of identifying

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Nathaniel Oigiangbe, O., M. Tamob, and I. Benjamin Igbinosaa. "BIOACTIVITY OF ALSTONIA BOONEI DE WILD LEAF ALKALOID ON THE GROWTH AND DEVELOPMENT OF MARUCA VITRATA FAB." Journal of Biopesticides 06, no. 02 (2013): 173–77. http://dx.doi.org/10.57182/jbiopestic.6.2.173-177.

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ABSTRACT The bioactivity of Alstonia boonei De Wild leaf alkaloid was tested under laboratory bioassay against the legume pod borer, Maruca vitrata Fabricius. The alkaloid was incorporated into standard M. vitrata artificial diet at five doses [0.00 % (Control), 0.02 %, 0.05 %, 0.10 % and 0.20 %], and fed to the newly emerged first instar M. vitrata larvae in plastic wells under laboratory conditions. Significant differences (P < 0.05) were recorded in the larval survival, wet and dry weights of the larvae at ten days after infestation (DAI). Mean larval survival ranged from 34.78 to 65.00

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G.E., Obi-Iyeke,, Michael, O.E., and Edokpiawe, S. "Assessment of trace metal elements in selected Plants around the vicinity of Ebedei Gas Flaring Station located at Ebedei Village, Ukwani Local Government Area, Delta State, Nigeria." Acta Biology Forum 3, no. 3 (2024): 26–29. https://doi.org/10.51470/abf.2024.3.3.26.

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This study evaluated the trace metal elements in selected plants around the Ebedei Gas Flaring Station, Ukwani Local Government Area, Delta State, Nigeria. The plants analyzed include Azadirachta indica, Cymbopogon citratus, Moringa oleifera, Carica papaya) and Alstonia boonei. The analysis revealed that Alstonia boonei had the highest concentration of Copper at 6.87 mg/kg, while the lowest concentration of Lead (0.06 mg/kg) was found in Carica papaya. The trace metal levels in the plants ranged from 0.06 mg/kg for Lead to 6.87 mg/kg for Copper, with Azadirachta indica showing moderate levels

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Omagha, R., E. T. Idowu, C. G. Alimba, A. O. Otubanjo, E. O. Agbaje, and H. C. N. Ajaegbu. "Physicochemical and phytochemical screening of six plants commonly used in the treatment of malaria in Nigeria." Journal of Phytomedicine and Therapeutics 19, no. 2 (2021): 483–501. http://dx.doi.org/10.4314/jopat.v19i2.6.

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Medicinal plants contain active compounds usually present as complex mixtures though at low concentrations, which accounts for the medicinal properties. Therefore it is important to identify and characterize these compounds. This study aims to quantify and characterize the physicochemical and phytochemical compositions of six plants commonly used in the treatment of malaria using High-Performance Liquid Chromatography (HPLC). These plants which are used individually or in combinations: Enantia chlorantha, Cymbopogon citratus, Curcuma longa, Carica papaya, Alstonia boonei and Mangifera indica,

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Valentine Egho, Eseoghene, Mr Fidelis Oyakhire, Enehizena Osaro Ogie, et al. "Effect of Aqueous Extract of Alstonia Boonei on Liver Enzymes and Its Anti-Inflammatory Activity on Formalin- Induced Arthritic Wistar Rats." International Journal of Medical Science and Clinical Invention 9, no. 09 (2022): 6263–69. http://dx.doi.org/10.18535/ijmsci/v9i09.06.

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The anti-inflammatory effect of the aqueous extract of Alstonia boonei on the level of liver biomarker in the plasma of normal and arthritic rats was evaluated using the formalin-induced arthritis inflammation tests. Thirty (30) adult female Wister rats were divided into six groups of five rats each. Group 1 as control, group 2(formalin induced group) while groups 3, 4 and 5 were respectively gavage with 150mg/kg, 300mg/kg and 600mg/kg body weight of the extract daily while group 6 was given reference drug( 5mg/kg body weight of indomethacin for 5 days). After formalin treatment, the paw thick

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Otuu, CA, I. C. Ekuma, R. N. N. Obiezue, et al. "Evaluation of Metabolite Compositions and Antimalarial Efficacy of Alstonia boonei (Cheese wood) in Plasmodiun-infected white albino mice (BALB/c)." Bulletins of Natural and Applied Sciences 2, no. 2 (2025): 34–40. https://doi.org/10.5281/zenodo.15505213.

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<strong>Abstract</strong> <strong>Background of the study:</strong> The recent increase in resistance of the malaria parasite has led to the urgent need for new and novel antimalarial molecules with different modes of action to combat the resistance. Plants have in the past proven to be sources of new molecules for drug development against diseases including malaria. <strong>Statement of problem:</strong> The increase in antimalarial drug resistance has greatly affected efforts towards the control and prevention of malaria in recent years. Hence, there is an urgent need for the discovery of ne

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Uadia, Patrick Ojeifo, and Kissinger ObaogiE Orumwensodia. "Antimalarial Activity of Extracts and Partially Purified Fractions of Alstonia boonei De Wild." African Scientist 24, no. 2 (2023): 305–17. http://dx.doi.org/10.26538/africanscientist.24.2.202306020.

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Alstonia boonei De wild is famed for several bioactive properties; this study measures its in vivo antimalarial potentials as well as phytochemical, nutritional and antioxidant properties. Variants of its stem bark extract were screened for phytochemical, nutritional and antioxidant properties using established procedures. In vivo antimalarial properties of extracts and fractions were determined against Plasmodium berghei NK65 infection in mice using chemo-suppressive, prophylactic, curative and mean survival time (MST) bioassays. Alkaloids, saponins, cardiac glycosides, tannins, flavonoids an

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XU, ZHEN-BANG, JOHN R. GREHAN, ZI-YI YANG, HAO-LIN GAN, and SHAO-JI HU. "Two new species of Palpifer Hampson (Lepidoptera: Hepialidae) from Yunnan, China." Zootaxa 5621, no. 5 (2025): 560–70. https://doi.org/10.11646/zootaxa.5621.5.4.

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Two new species of the genus Palpifer Hampson, 1893 are described. The first species, named P. qinglai sp. nov. from Yunnan University in Kunming, Yunnan, China, is similar to P. sexnotatus (Moore, 1879) but distinguished by differences in forewing pattern, male genitalia structure and DNA barcode sequence. The second species, named P. bazi sp. nov. from Mengzi, Honghe, Yunnan, China, resembles P. boonei Grehan & Mielke, 2019 but also differs in the same characteristics.

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Bräuer, Suzanna, Hinsby Cadillo-Quiroz, Nikos Kyrpides, et al. "Genome of Methanoregula boonei 6A8 reveals adaptations to oligotrophic peatland environments." Microbiology 161, no. 8 (2015): 1572–81. http://dx.doi.org/10.1099/mic.0.000117.

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Uadia, Jeremiah Ogboma, and Osahon Kennedy Ogbeide. "Comparative Studies of the Phytochemical Analysis, Mineral Content, Antibacterial Activity and Antioxidant Potential of Ethyl Acetate Extract of Alstonia Boonei Leaves and Stem Bark." Walisongo Journal of Chemistry 7, no. 1 (2024): 57–69. https://doi.org/10.21580/wjc.v7i1.20667.

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Folkloric medicine has reported the effectiveness of Alstonia boonei stem bark and leaf extracts in treating and managing different ailments. Hence, this research is a comparative evaluation of the phytochemicals; antioxidant potential, mineral content, and antibacterial capacity of ethyl acetate extract of Alstonia boonei leaves and stem bark. Phytochemical analysis was determined using standard methods; mineral composition was determined using a flame photometer and an atomic absorption spectrophotometer; antibacterial capacity was analysed by agar-well diffusion method; and antioxidant pote

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Omoya, Funmilola, and Taiwo Folayele Oyebola. "Antiplasmodial activity of stem bark and leaves of Alstonia boonei (De Wild)." Journal of Microbiology & Experimentation 7, no. 5 (2019): 241–45. http://dx.doi.org/10.15406/jmen.2019.07.00267.

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Okoye, Nkeoma, and Chukwuma Okoye. "Anti-oxidant and Antimicrobial Flavonoid Glycosides from Alstonia boonei De Wild Leaves." British Journal of Pharmaceutical Research 10, no. 6 (2016): 1–9. http://dx.doi.org/10.9734/bjpr/2016/24809.

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Iyiola, O. A., A. Y. Tijani, and K. M. Lateef. "Antimalarial Activity of Ethanolic Stem Bark Extract of Alstonia boonei in Mice." Asian Journal of Biological Sciences 4, no. 3 (2011): 235–43. http://dx.doi.org/10.3923/ajbs.2011.235.243.

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Ogueke, Chika Crescence, Joachim Uwaleke, Clifford Ifeanyi Owuamanam, and Beluonwu Okolue. "Antimicrobial activities of Alstonia boonei stem bark, a Nigerian traditional medicinal plant." Asian Pacific Journal of Tropical Disease 4 (September 2014): S957—S962. http://dx.doi.org/10.1016/s2222-1808(14)60766-0.

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Nando, Oro Anne-Nathalie, Yao Kan Séraphin Diby, Ténon Coulibaly, Akpa Alexandre Moise Akpesse, and Kouassi Philippe Kouassi. "Effets insecticides des extraits aqueux de trois plantes (Ocimum gratissimum, Alstonia boonei et Nauclea latifolia) sur les termites prédateurs du manioc (Manihot esculenta Crantz 1766) dans la région d'Agboville (Côte d'Ivoire)." European Scientific Journal, ESJ 20, no. 24 (2024): 80. http://dx.doi.org/10.19044/esj.2024.v20n24p80.

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Le manioc représente l’une des principales cultures de production de racines tubéreuses en Afrique conduisant à plusieurs variétés de produits alimentaires. Malheureusement, les termites causent de sérieux dommages à la culture, entrainant une considérable perte de production. La méthode de lutte la plus répandue est l’utilisation des insecticides synthétiques qui représentent un risque réel pour les organismes vivants et l’environnement. Dans la recherche d’alternatives à ces insecticides chimiques, cette présente étude, réalisée dans le département d’Agboville, a pour objectif d’évaluer l’ef

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