Relevant bibliographies by topics / Bordetella Infections

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Bordetella Infections'

Author: Grafiati
Published: 4 June 2021
Last updated: 13 February 2022

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Journal articles on the topic "Bordetella Infections"

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Wolfe, Daniel N., Elizabeth M. Goebel, Ottar N. Bjornstad, Olivier Restif, and Eric T. Harvill. "The O Antigen Enables Bordetella parapertussis To Avoid Bordetella pertussis-Induced Immunity." Infection and Immunity 75, no. 10 (2007): 4972–79. http://dx.doi.org/10.1128/iai.00763-07.

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ABSTRACT Bordetella pertussis and Bordetella parapertussis are closely related endemic human pathogens which cause whooping cough, a disease that is reemerging in human populations. Despite how closely related these pathogens are, their coexistence and the limited efficacy of B. pertussis vaccines against B. parapertussis suggest a lack of cross-protective immunity between the two. We sought to address the ability of infection-induced immunity against one of these pathogens to protect against subsequent infection by the other using a mouse model of infection. Immunity induced by B. parapertussis infection protected against subsequent infections by either species. However, immunity induced by B. pertussis infection prevented subsequent B. pertussis infections but did not protect against B. parapertussis infections. The O antigen of B. parapertussis inhibited binding of antibodies to the bacterial surface and was required for B. parapertussis to colonize mice convalescent from B. pertussis infection. Thus, the O antigen of B. parapertussis confers asymmetrical cross-immunity between the causative agents of whooping cough. We propose that these findings warrant investigation of the relative role of B. parapertussis in the resurgence of whooping cough.
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Mattoo, Seema, and James D. Cherry. "Molecular Pathogenesis, Epidemiology, and Clinical Manifestations of Respiratory Infections Due to Bordetella pertussis and Other Bordetella Subspecies." Clinical Microbiology Reviews 18, no. 2 (2005): 326–82. http://dx.doi.org/10.1128/cmr.18.2.326-382.2005.

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SUMMARY Bordetella respiratory infections are common in people (B. pertussis) and in animals (B. bronchiseptica). During the last two decades, much has been learned about the virulence determinants, pathogenesis, and immunity of Bordetella. Clinically, the full spectrum of disease due to B. pertussis infection is now understood, and infections in adolescents and adults are recognized as the reservoir for cyclic outbreaks of disease. DTaP vaccines, which are less reactogenic than DTP vaccines, are now in general use in many developed countries, and it is expected that the expansion of their use to adolescents and adults will have a significant impact on reducing pertussis and perhaps decrease the circulation of B. pertussis. Future studies should seek to determine the cause of the unique cough which is associated with Bordetella respiratory infections. It is also hoped that data gathered from molecular Bordetella research will lead to a new generation of DTaP vaccines which provide greater efficacy than is provided by today's vaccines.
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Welsh, RD. "Bordetella bronchiseptica infections in cats." Journal of the American Animal Hospital Association 32, no. 2 (1996): 153–58. http://dx.doi.org/10.5326/15473317-32-2-153.

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Eleven cats from 10 different households or catteries were diagnosed with Bordetella bronchiseptica (B. bronchiseptica) infections. Seven cases proved fatal, in which B. bronchiseptica pneumonia was a primary or significant cause of death. The majority of cases (seven of 11) were in kittens less than eight weeks old. A universal complaint was coughing. Bacterial cultures from transtracheal washes or lung tissue were successful in diagnosing bordetellosis in all cases. This report indicates that B. bronchiseptica should be a consideration in a cat presenting with a primary complaint of coughing and may be a relatively common disease in catteries or shelter environments.
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Betsou, F., and N. Guiso. "Physiopathologie des infections à Bordetella." Médecine et Maladies Infectieuses 25 (January 1995): 1230–32. http://dx.doi.org/10.1016/s0399-077x(05)81672-5.

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Guiso, N. "Physiopathologie des infections à Bordetella." Archives de Pédiatrie 2, no. 12 (1995): 1226. http://dx.doi.org/10.1016/0929-693x(95)90060-g.

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Kawai, Hirokazu, Tatsuo Aoyama, Yuji Murase, Chieko Tamura, and Atsushi Imaizump. "A Causal Relationship between Bordetella pertussis and Bordetella parapertussis Infections." Scandinavian Journal of Infectious Diseases 28, no. 4 (1996): 377–81. http://dx.doi.org/10.3109/00365549609037923.

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Woolfrey, B. F., and J. A. Moody. "Human infections associated with Bordetella bronchiseptica." Clinical Microbiology Reviews 4, no. 3 (1991): 243–55. http://dx.doi.org/10.1128/cmr.4.3.243.

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This study examines the potential of Bordetella bronchiseptica to act as a human pathogen. After encountering two patients from whom B. bronchiseptica was isolated, we searched the literature and found 23 reports in which a human infection was reported in association with B. bronchiseptica. As a basis for evaluating these cases, we summarize the literature about the current microbiological status of B. bronchiseptica, the pathology and pathogenic mechanisms associated with the microorganism, and the likelihood of it acting as a commensal or colonizer. From this review we conclude that B. bronchiseptica has been rarely isolated from humans despite their considerable exposure to animal sources. Evidence suggests that B. bronchiseptica may be rarely encountered as a commensal or colonizer of the respiratory tract of humans and rarely in association with infection. When found as a probable pathogen, most infections have been respiratory tract in origin and have occurred in severely compromised hosts.
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Kirimanjeswara, Girish S., Paul B. Mann, and Eric T. Harvill. "Role of Antibodies in Immunity to Bordetella Infections." Infection and Immunity 71, no. 4 (2003): 1719–24. http://dx.doi.org/10.1128/iai.71.4.1719-1724.2003.

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ABSTRACT The persistence of Bordetella pertussis and B. parapertussis within vaccinated populations and the reemergence of associated disease highlight the need to better understand protective immunity. The present study examined host immunity to bordetellae and addressed potential concerns about the mouse model by using a comparative approach including the closely related mouse pathogen B. bronchiseptica. As previously observed with B. pertussis, all three organisms persisted throughout the respiratory tracts of B-cell-deficient mice, indicating that B cells are required for bacterial clearance. However, adoptively transferred antibodies rapidly cleared B. bronchiseptica but not human pathogens. These results obtained with the mouse model are consistent with human clinical observations, including the lack of correlation between antibody titers and protection, as well as the limited efficacy of intravenous immunoglobulin treatments against human disease. Together, this evidence suggests that the mouse model accurately reflects substantial differences between immunities to these organisms. Although both B. pertussis and B. parapertussis are more closely related to B. bronchiseptica than they are to each other, they share the ability to resist rapid clearance from the lower respiratory tract by adoptively transferred antibodies, an adaptation that correlates with their emergence as human pathogens that circulate within vaccinated populations.
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Sloan, Gina Parise, Cheraton F. Love, Neelima Sukumar, Meenu Mishra, and Rajendar Deora. "The Bordetella Bps Polysaccharide Is Critical for Biofilm Development in the Mouse Respiratory Tract." Journal of Bacteriology 189, no. 22 (2007): 8270–76. http://dx.doi.org/10.1128/jb.00785-07.

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ABSTRACT Bordetellae are respiratory pathogens that infect both humans and animals. Bordetella bronchiseptica establishes asymptomatic and long-term to life-long infections of animal nasopharynges. While the human pathogen Bordetella pertussis is the etiological agent of the acute disease whooping cough in infants and young children, it is now being increasingly isolated from the nasopharynges of vaccinated adolescents and adults who sometimes show milder symptoms, such as prolonged cough illness. Although it has been shown that Bordetella can form biofilms in vitro, nothing is known about its biofilm mode of existence in mammalian hosts. Using indirect immunofluorescence and scanning electron microscopy, we examined nasal tissues from mice infected with B. bronchiseptica. Our results demonstrate that a wild-type strain formed robust biofilms that were adherent to the nasal epithelium and displayed architectural attributes characteristic of a number of bacterial biofilms formed on inert surfaces. We have previously shown that the Bordetella Bps polysaccharide encoded by the bpsABCD locus is critical for the stability and maintenance of three-dimensional structures of biofilms. We show here that Bps is essential for the formation of efficient nasal biofilms and is required for the colonization of the nose. Our results document a biofilm lifestyle for Bordetella in mammalian respiratory tracts and highlight the essential role of the Bps polysaccharide in this process and in persistence of the nares.
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Woolfrey, B. F., and J. A. Moody. "Human infections associated with Bordetella bronchiseptica." Clinical Microbiology Reviews 4, no. 3 (1991): 243–55. http://dx.doi.org/10.1128/cmr.4.3.243-255.1991.

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Dissertations / Theses on the topic "Bordetella Infections"

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Pavic, Espinoza Ivana, Medina Sandy Bendezu, Alzamora Angella Herrera, et al. "High prevalence of Bordetella pertussis in severe acute respiratory infections in hospitalized children under 5 years in Lima, Peru." Universidad Peruana de Ciencias Aplicadas (UPC), 2015. http://hdl.handle.net/10757/582376.

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ASTMH 64th Annual Meeting. October 25-29, 2015 Philadelphia Marriott Downtown Philadelphia, Pennsylvania USA
Acute respiratory infections (ARI) are the main cause of morbidity and mortality in children under 5 years worldwide. Bordetella pertussis is a highly contagious bacterium that can cause serious illness, and approximately half of infected infants less than 1 year old are hospitalized. Also, pertussis immunization series is not completed until six months of age, leaving young infants vulnerable to pertussis. In Peru, pertussis is an increasing health problem despite immunization efforts, and the role of B. pertussis in ARI is unknown. We determined the prevalence of B. pertussis among children under 5 years old admitted to Hospital Nacional Cayetano Heredia in Lima with diagnosis of ARI between Jan-2009 and Dec 2010. Epidemiological and clinical features were collected, and presence of B. pertussis was determined by PCR (pertussis toxin and IS481 gene). A total of 596 nasopharyngeal samples among children under 5 years were analyzed. In 114 (19.1%) samples were positive for B. pertussis. 32.5% of sample positive to B. pertussis were diagnosed as viral pneumonia at diagnosis. Importantly, 71.9% of cases were under 12 months of age and 58.8% have been contact with other ARI infected people. Significant differences in clinical symptoms between the total ARI cases and B. pertussis cases were not found. The most frequent symptoms in B. pertussis cases were fever (100%), rhinorrhea 78%, cough 71.9% and respiratory distress 60.5%. One child died due to the infection. B. pertussis cases showed a seasonal distribution with peaks during the months March June and November. This study shows the high prevalence of B. pertussis in infants who were hospitalized due to severe acute respiratory infections in Lima, Peru. Epidemiologic surveillance programs for B. pertussis are essential in the future in Peru
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Kammoun, Hana. "Protection contre les infections hétérologues par la souche vaccinale atténuée Bordetella pertussis BPZE1." Thesis, Lille 2, 2012. http://www.theses.fr/2012LIL2S032.

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Les infections respiratoires font aujourd’hui encore partie des premières causes de morbidité et mortalité à l’échelle planétaire. De nombreux pathogènes viraux ou bactériens sont responsables de ces infections. Pour certaines d’entre elles aucun vaccin n’est disponible, comme c’est le cas du virus respiratoire syncytial, et pour d’autres les vaccins actuels souffrent d’importantes limitations. Ces limitations sont souvent liées à la variation antigénique et l’évolution constante des souches circulantes, comme dans le cas du virus de la grippe ou de Streptococcus pneumoniae. Pour d’autres, comme la coqueluche, le schéma vaccinal actuel ne permet pas de suffisamment protéger la population la plus vulnérable, càd. les enfants en bas age. La majorité des vaccins actuels sont classiquement administrés par voie parentérale. Or, la porte d’entrée des pathogènes respiratoires est la muqueuse nasale. Dès lors une immunisation intranasale semblerait plus indiquée. La vaccination intranasale présente l’avantage de cibler à la fois l’immunité locale et l’immunité systémique. D’autre part, elle ne fait pas appel à des procédures invasives et est facile à pratiquer.Dans cette optique, un nouveau vaccin vivant atténué contre la coqueluche a été développé dans le laboratoire d’accueil. Ce vaccin, appelé BPZE1, consiste en une souche génétiquement atténuée de Bordetella pertussis, l’agent étiologique de la coqueluche. Les études précliniques ont montré l’efficacité de cette souche vaccinale après une seule administration nasale. De plus, les premiers essais cliniques chez les adultes ont démontré l’innocuité et l’immunogénicité de cette souche. Au-delà de l’intérêt pour la vaccination contre la coqueluche, la souche BPZE1 présente aussi des propriétés anti-inflammatoires qui protègent contre l’asthme et contre la mortalité induite par le virus hautement pathogène de la grippe.Dans la première partie de ma thèse, nous nous sommes intéressés à étudier la protection induite par BPZE1 contre des infections hétérologues. D’abord, nous avons montré qu’une seule dose de BPZE1 protège contre une infection létale par Bordetella bronchiseptica, une bactérie appartenant au même genre que la souche vaccinale. La protection se traduit par une réduction de l’inflammation pulmonaire médiée par les cellules T régulatrices, par une augmentation significative de survie des souris infectées et une diminution de la charge bactérienne. Ensuite, nous avons étudié la protection hétérologue de BPZE1 contre une bactérie non apparentées, S. pneumoniae. Nous avons montré que l’administration intranasale de BPZE1 protège contre la mortalité induite par S. pneumoniae. Cette protection est dépendante du facteur de différenciation myéloide 88 (MyD88). Dans la deuxième partie de ma thèse, nous nous sommes intéressés à combiner cet effet anti-inflammatoire, non spécifique de BPZE1 avec l’induction d’une réponse immunitaire spécifique contre un antigène hétérologue. Ainsi, nous avons étudié la possibilité d’utiliser BPZE1 comme plateforme biotechnologique pour la présentation d’antigènes protecteurs hétérologues afin de développer des vaccins nasaux multivalents. Trois différents modèles (virus d’influenza, virus respiratoire syncytial et S. pneumoniae) ont été développés en exprimant les antigènes les mieux conservés et les plus prometteurs dans la souche BPZE1. L’ensemble de ces travaux de recherche ont montré que BPZE1 est un candidat vaccinal prometteur pour exprimer des antigènes hétérologues et protéger contre les infections respiratoires hétérologues
Respiratory infections are still among the leading causes of morbidity and mortality worldwide. Many different bacterial or viral pathogens are responsible for these infections. For some of them no vaccine is available, as is the case for the respiratory syncytial virus, and other current vaccines suffer from significant limitations. These limitations are mainly related to the antigenic variation and the constant evolution of circulating strains, as is the case of influenza virus and Streptococcus pneumoniae. For others, such as pertussis, the current vaccination programs do not result in sufficient protection of the most vulnerable population, i. e. very young infants. Most of the current vaccines are administered parenterally. However, the port of entry of respiratory pathogens is the nasal mucosa. Intranasal vaccination seems therefore more appropriate. Intranasal vaccination has the advantage of targeting both the local and the systemic immune system. In addition, it is non invasive (needle-free) and easy to apply.In this context, a new, live attenuated vaccine against pertussis has been developed in the host laboratory. The vaccine, named BPZE1, is a genetically attenuated Bordetella pertussis strain, the causative agent of whooping cough. Preclinical studies have demonstrated the efficacy of this vaccine strain after a single nasal administration. In addition, the first clinical trials in adults have demonstrated the safety and efficacy of this strain. Beyond pertussis vaccination, BPZE1 has also anti-inflammatory properties that protect against asthma and against mortality induced by highly pathogenic influenza.In the first part of my thesis, we were interested in studying the protection induced by BPZE1 against heterologous infections. Firstly, we showed that a single administration of BPZE1 conferred heterologous protection against a lethal infection with Bordetella bronchiseptica. This protection was evidenced by a reduction of lung inflammation mediated by regulatory T cells, a significant increase in survival of the challenged mice and a significant decrease in bacterial load.Then, we have investigated the heterologous protection of BPZE1 against an unrelated bacterium, S. pneumonia. We found that an intranasal administration of BPZE1 protected against mortality caused by S. pneumoniae. This protection was MyD88 dependent.In the second part of my thesis, we were interested in studying the possibility of using BPZE1 as a biotechnological platform for the presentation of heterologous protective antigens to develop multivalent vaccines. Three different models (influenza virus, respiratory syncytial virus and S. pneumoniae) were developed by expressing the most promising and conserved antigens in BPZE1.In conclusion, our data indicates that BPZE1 is a promising candidate vaccine to express foreign antigens and to protect against heterologous respiratory infections
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Colombi, Débora. "Clonagem e expressão da Região Hep do domínio de Heparina da Proteína hemaglutinina filamentosa ( FHA) da bactéria Bordella pertussis em sistemas heterólogos." Universidade de São Paulo, 2003. http://www.teses.usp.br/teses/disponiveis/46/46131/tde-13112014-173027/.

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Bordetella pertussis, o agente etiológico da coqueluche ou tosse comprida, que estabelece a infecção através da fixação bacteriana no epitélio do trato respiratório superior. Os principais mediadores de adesão da bactéria são a toxina pertússica (PT) e a hemaglutinina filamentosa (FHA). A FHA é a adesina majoritária e contém pelo menos 4 domínios: porção Nterminal, domínio de reconhecimento de carboidrato (CRD) (FHA1141-1279), trinca de aminoácidos Arginina-Glicina-Ácido aspártico (RGD) (FHA1097-1099) e o sítio de ligação a heparina (domínio Hep) (FHA442-863). Neste trabalho, foi realizado a amplificação de duas regiões do domínio de ligação à heparina, as regiões MAL80 (FHA299-873) e HEP (FHA430-873). As regiões foram amplificadas, clonadas no vetor de expressão pAE, expressas utilizando a cepa BL21 SI de E. coli e purificadas. A proteína HEP purificada de E. coli possui baixa afinidade por heparina e não é capaz de aglutinar hemácias. A proteína recombinante HEP purificada foi utilizada para a produção de anticorpos. Através do experimento de ELISA foi demonstrado que o anti-soro anti-HEP é capaz de reconhecer além da região HEP, a região MAL80 e a proteína FHA. Estes resultados foram confirmados por experimentos de Western. Neste período também foi realizada a amplificação do domínio HEP de FHA e da subunidade S1 da toxina pertússica (PT) de B. pertussis através do método de TAP Express. Este método envolve duas reações de PCR e no final do processo é obtido um fragmento que contém uma região promotora (CMV), uma seqüência codificadora e uma região terminadora (SV40), que está pronto para ser introduzido e expresso em animais. De posse deste material e da proteína recombinante HEP, foi realizado o desafio intracerebral com Bordetella pertussis e através do monitoramento dos camundongos foi observado que nenhum dos candidatos testados foi capaz de proteger os animais contra B. pertussis. Foi realizado também a expressão do domínio Hep em lactobacilos, visando um possível sistema de imunizações de mucosas. Os anticorpos produzidos nos camundongos imunizados com a proteína HEP expressa em E. coli, lactobacilos e por vacina de DNA foram capazes de inibir a hemaglutinação promovida pela proteína FHA.
Bordetelfa pertussis, the agent of whopping cough, establishes infection by attaching to the ciliated epithelial cells of the respiratory tract. The bacterial adherence is mediated by pertussis toxin and filamentous hemagglutinin (FHA). FHA is the major adhesin of B. pertussis and displays multipie adherence activities. FHA contains four distin\'ct domains that exhibit specific affinities for different ligands or receptor, the amino-terminal end, the RGD triplet (FHA1097-1099), the lectin domain (FHA1141-1279) and the heparin-binding domain (FHA442-863). In this study, two overlapping regions of the heparin-binding domain, Mal80 (FHA299-873) and Hep (FHA442-873), were amplified by peR and subcloned in pAE expression vectors for E. coli. The fusion proteins in pAE were transformed in E. coli BL21 SI, induced with NaCI 0,3 M and purified using a nickel-charged metal chelating resin. The purified protein has low heparin affinity and does not have hemagglutination activity. The purified protein HEP was used to produce polyclonal antibodies in mouse. The anti-HEP antibodies are able to recognize the HEP, MAL80 and FHA proteins in ELISA and western assays, but anti-FHA only recognized the FHA protein. The genetically detoxified S1 subunit of pertussis toxin and Hep domain were amplified by the TAP Express method. There are two PCR reactions involved in the TAP processo At the end of the process the fragment of interest will carry a CMV promoter and a SV40 terminator and is ready to be introduced into animals or cell by transfection. Groups were immunized with proteins and/or DNA, challenged i.c. with a lethal dose of live Bordetelfa pertussis and the survival was monitored. No groups were protected against the challenge. The recombinant protein HEP were also expressed in Lactobacilfus aiming the development of potential mucosal vaccines. The polyclonal antibodies produce in mouse immunized with DNA and protein Hep expressed in E. coli and Lactobacillus were able to inhibition the FHA hemagglutination activity.
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Gueirard, Pascale. "Infection respiratoire à Bordetella bronchiseptica : Texte imprimé : Facteurs impliqués, réponses immunes, conséquences vaccinales." Paris 5, 1995. http://www.theses.fr/1995PA05CD09.

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Bordetella bronchiseptica (BBS) est responsable d'infections respiratoires chez un grand nombres de mammifères. Chez l'homme, cette bactérie est surtout isolée chez des patients immunodéficients ou ayant un état général affaibli. Dans un modèle murin d'infection respiratoire, nous avons étudié certains aspects de la pathogénie de l'infection par BBS, dans le but de mettre au point un vaccin efficace contre l'infection par cette bactérie chez l'animal. Tous les facteurs communs impliqués dans la virulence de Bordella pertussis semblent être également synthétisés par B B S , incluant à la fois des adhésines telles que l'hémagglutinine filamenteuse (FHA), la Pertactine et les Fimbria, et des toxines telles que la Toxine dermonécrotique, la Toxine cytotrachéale et l'Adénylcyclase-hémolysine (AC-Hly), à l'exception de la toxine de permussis. Nous avons montré que l'expression de l'AC-Hly est indispensable à l'initiation de l'infection et que ce facteur est un antigène protecteur contre l'infection par BBS dans le modèle murin. Outre sa capacité à synthétiser adhésines et toxines, BBS possède également un potentiel invasif et est capable de persister, in vitro, à l'intérieur de cellules épithéliales et de cellules dentritiques. In vivo, la description de cas d'infections humaines récidivantes à BBS nous a conforté dans notre hypothèse sur la capacité de la bactérie à persister chez l'hôte. L'étude des réponses immunes chez l'hôte a mis en évidence à la fois une réponse à médiation humorale et à médiation cellulaire après infection. Des anticorps anti-AC-Hly et anti-FHA sont détectés dans les sérums précoces et les lavages bronchoalvéolaires des souris infectées. Les anticorps sériques persistent pendant au moins dix semaines après l'infection, ce qui est un argument indirect pour la persistance de la bactérie in vivo. La réponse anticorps sérique spécifique est ajoritairement composée d'IgG2a et d'IgA. A partir des splénocytes de souris infectées, nous avons mis en évidence une réponse cellulaire T persistante de Type Th 1 vis-à-vis de la bactérie entière et de l'AC-Hly. Tandis que la réponse anticorps, en particulier la réponse mucosale locale permet une élimination rapide de la bactérie, la réponse cellulaire participe à la destruction du réservoir intracellulaire de bactéries. En tenant compte de toutes ces données, nous avons comparé les réponses immunes après infection chez des souris vaccinées avec un vaccin entier ou un vaccin acellulaire composé d'AC-Hly purifiée. La protection contre la colonisation pulmonaire est bonne et équivalente chez les deux groupes de souris. La réponse anticorps spécifique est majoritairement composée d'IgG2a et la réponse cellulaire de type Th1, de même nature que la réponse immune obtenue après une primo-infection.
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SCHAEFFER, LYNDSAY MORGAN. "THE ROLE OF PHAGOCYTIC DEFENSES AND INNATE IMMUNITY IN THE CLEARANCE OF BORDETELLA PERTUSSIS INFECTIONS." University of Cincinnati / OhioLINK, 2004. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1083265032.

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Galhardo, Cynthia Soares. "Fatores que determinam a produção de IL-12 em macrófagos murinos ativados por Bordetella pertussis e B. parapertussis." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/87/87131/tde-15052014-101030/.

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Bordetella pertussis e B. parapertussis são agentes etiológicos da coqueluche. A IL-12 liga a imunidade inata e adaptativa. Investigamos alguns mecanismos que controlam a síntese de IL-12 em macrófagos medulares murinos (MfDM) ativados in vitro com estas duas espécies de bactérias. Demonstramos que IL-12p40 e TNF-a foram produzidos pelos MfDM ativados com qualquer uma das bactérias. A síntese de IL-12p40 foi dependente de TNF-a, MyD88 e NFkB e independente de MAPK p38 e ERK 1/2. Durante a estimulação com B. pertussis a produção de IL-12p40 foi dependente de TLR-4, mas com B. parapertussis envolveu outras vias independentes de MyD88 e TLR-4. Estas bactérias não induziram a síntese de IL-12p70, necessitando de sinais moleculares adicionais de IFN-g, que aumentou a síntese desta citocina. A produção de IL-12 p70 aumentou após o bloqueio das vias PI3K, MAPK p38 e ERK1/2 assim como após a adição exógena de PT sobre MfDM ativados com B. parapertussis. Portanto, diversas vias de sinais dependentes e independentes de TLR-4 controlam a produção de IL-12 neste modelo.
Bordetella pertussis and B. parapertussis are etiological agents of whooping cough. IL-12 links the innate and adaptive immunity. We investigated the ability of both bacteria to modulate IL-12 by in vitro activation of bone marrow derived macrophages (MfDM). We demonstrated that IL-12p40 and TNF-a were produced after stimulation of cells with either bacterium. IL-12p40 production was dependent on TNF-a, MyD88 and NFkB but independent of MAPK p38 and ERK 1/2. During B. pertussis activation the production of IL-12p40 was dependent on TLR-4, while B. parapertussis activation was MyD88 and TLR-4 independent. However, the bacteria alone did not induce IL-12p70 synthesis, requiring IFN-g as an additional signal. Evidences indicated MAPK p38, ERK1/2 and PI3K during B. pertussis and B. parapertussis activation, as well as the exogenous addition of PT to B. parapertussis activated MfDM, was critical for the up regulation of IL-12p70. This finding indicates that different TLR-4 dependent and independent signaling pathways may control the production of IL-12 in this model.
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Alonso, Jean-Michel. "Deux approches différentes dans la stratégie d'immunoprévention des infections bactériennes transmissibles : le modèle Yersinia et le modèle Bordetella." Paris 11, 1988. http://www.theses.fr/1988PA112048.

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La peste, zoonose accidentellement transmissible à l’homme, due à Yersinia pestis, provoquant une infection systémique, par invasion cellulaire, et la coqueluche, infection toxinique, non invasive, du tractus respiratoire, strictement humaine, due à Bordetella pertussis, sont deux modèles de maladies infectieuses épidémiques totalement différents, par leur épidémiologie, leurs processus physiopathologiques et par les mécanismes immunitaires qui s'opposent à leur développement. Les stratégies d'immunoprévention les plus rationnelles, fondées sur les études physiopathologiques, que nous avons réalisées, nous paraissent être, dans le cas de la peste, l'exploitation des compétitions immunitaires exercées par les infections bactéries phylogénétiquement proches de Y. Ptstis, y. Pstudotu berculosis et Y. Enterocolitica, au sein du réservoir murin sauvage, et, dans le cas de la coqueluche, l'immunisation spécifique des populations exposés contre certains déterminants d'lmmunogénicité, synthétisés et sécrétés par B. Pertussis, et dont le rôle dans le processus pathogène est précisément identifié : l'hémagglutinine filamenteuse, principal facteur d'adhésion, conditionnement l'intensité du syndrome infectieux, dont dépend l'induction du syndrome toxinique, alors que l'adényl cyclase apparaît comme la principale toxine impliqué dans les effets cytopathogènes pour le tractus respiratoire. Dans ces deux modèles, l'approche physiopathologique est essentielle pour choisir les stratégies de recherches analytiques, structurales, moléculaires, et génétiques, les mieux adaptées à la caractérisation des immunogènes et des procédés d'immunisation les plus rationnels contre ces infections.
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Saiki-Macedo, Stephanie, Jorge Valverde-Ezeta, Angela Cornejo-Tapia, et al. "Identfication of viral and bacterial etiologic agents of the pertussis-like syndrome in children under 5 years old hospitalized." BioMed Central Ltd, 2019. http://hdl.handle.net/10757/652471.

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Background: Acute respiratory infections (ARIs) represent an important cause of morbidity and mortality in children, remaining a major public health concern, especially affecting children under 5 years old from low-income countries. Unfortunately, information regarding their epidemiology is still limited in Peru. Methods: A secondary data analysis was performed from a previous cross-sectional study conducted in children with a probable diagnosis of Pertussis from January 2010 to July 2012. All samples were analyzed via Polymerase Chain Reaction (PCR) for the following etiologies: Influenza-A, Influenza-B, RSV-A, RSV-B, Adenovirus, Parainfluenza 1 virus, Parainfluenza 2 virus, Parainfluenza 3 virus, Mycoplasma pneumoniae and Chlamydia pneumoniae. Results: A total of 288 patients were included. The most common pathogen isolated was Adenovirus (49%), followed by Bordetella pertussis (41%) from our previous investigation, the most prevelant microorganisms were Mycoplasma pneumonia (26%) and Influenza-B (19.8%). Coinfections were reported in 58% of samples and the most common association was found between B. pertussis and Adenovirus (12.2%). Conclusions: There was a high prevalence of Adenovirus, Mycoplasma pneumoniae and other etiologies in patients with a probable diagnosis of pertussis. Despite the presence of persistent cough lasting at least two weeks and other clinical characteristics highly suspicious of pertussis, secondary etiologies should be considered in children under 5 years-old in order to give a proper treatment.
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Alonso, Jean-Michel. "Deux approches différentes dans la stratégie d'immunoprévention des infections bactériennes transmissibles le modèle Yersinia et le modèle Bordetella /." Grenoble 2 : ANRT, 1988. http://catalogue.bnf.fr/ark:/12148/cb376112638.

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Naninck, Thibaut. "Etude de l'infection par Bordetella pertussis dans un modèle de coqueluche chez le primate non-humain : Apports de l'imagerie in vivo." Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLS526.

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La coqueluche est une pathologie due à la bactérie Bordetella pertussis qui touche les voies respiratoires des patients infectés causant toux, leucocytose, fièvre, et dont les symptômes peuvent aller jusqu’au décès chez les individus les plus à risque (nouveau-nés et enfants immunodéprimés en particulier). Ciblée par différents programmes vaccinaux depuis de nombreuses années, cette pathologie sévit à nouveau dans de nombreux pays développés où le nombre de cas augmente fortement depuis la fin des années 2000. Cette résurgence montre la nécessité de développer de nouvelles stratégies afin de comprendre les mécanismes de l’infection par B. pertussis. Dans ce contexte, la recherche préclinique apparaît comme essentielle pour comprendre la physiopathologie de la coqueluche. De nombreux modèles animaux ont été décrits pour l’étude de la coqueluche mais aucun de ces modèles ne permet de reproduire l’ensemble du spectre des symptômes cliniques de la pathologie, notamment la toux. Cependant, au cours des dernières années un modèle d’infection par Bordetella pertussis chez le jeune babouin a été développé aux Etats-Unis et permet de reproduire la pathologie observée chez l’homme, notamment concernant la toux et la transmission. Ce modèle semble ainsi très prometteur pour l’étude de la physiopathologie de la coqueluche.Cependant, de nombreuses inconnues subsistent dans ce modèle, notamment concernant la colonisation bactérienne et les interactions entre la bactérie et l’hôte. Nous avons ainsi cherché dans cette étude à évaluer d’une part l’impact de différents facteurs comme l’âge des animaux, la dose d’infection ainsi que la voie d’exposition sur la pathologie déclarée par les babouins suite à l’infection par la souche B1917 de B. pertussis afin de pouvoir proposer un parallèle avec les données cliniques disponibles. Nous avons également développé l’utilisation de techniques d’imagerie in vivo comme l’endomicroscopie confocale couplée à la bronchoscopie afin d’étudier la localisation et la cinétique de colonisation et certaines interactions du pathogène dans le tractus respiratoire inférieur au cours de la pathologie. Cette étude nous a ainsi permis d’approfondir les connaissances de physiopathologie de la coqueluche dans ce modèle babouin et consolidera cet outil précieux pour l’évaluation des futures stratégies de prévention contre cette pathologie
Whooping cough, or pertussis, is a respiratory disease caused by Bordetella pertussis bacterial colonization of human airways. Main symptoms are cough, leukocytosis, fever and may even be lethal for some patients (e.g. newborn infants and immuno-deficient patients). Despite a good vaccination coverage worldwide against pertussis, whooping cough cases have been re-increasing in several developed countries in the past twenty years. This resurgence points out the crucial need to develop new control strategies and to better understand pertussis pathophysiology, notably using appropriate animal models. Numerous preclinical models including mice, rats, rabbits and swine have been described for B. pertussis infection studies. However, none of these models reproduce the full spectrum of clinical pertussis symptoms, especially cough. The recent baboon model of whooping cough described in the last few years in the US appears to be a very relevant model for pertussis pathophysiology studies as these animals reproduced all clinical symptoms as observed in humans including cough.However, many aspects of bacterial colonization and interactions with the host have yet to be described in this model.We have then evaluated diverse parameters such as animal age, the inoculum dose and the exposition route on the pathology symptoms and immune responses developed by baboons following B. pertussis B1917 strain inoculation in order to draw a parallel with human clinical data. We also developed in this model in vivo imaging techniques like confocal endomicroscopy coupled with bronchoscopy in order to evaluate bacterial colonization kinetics, localization and some interactions in the lower respiratory tract of infected baboons. Then, this study brought additional data on whooping cough physiopathology in this baboon model, which will be crucial for evaluating future prevention strategies against pertussis disease
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Books on the topic "Bordetella Infections"

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Kokuritsu Yobō Eisei Kenkyūjo (Japan) and International Association of Biological Standardization., eds. International Symposium on Pertussis, Evaluation, and Research on Acellular Pertussis Vaccines: Proceedings of a symposium supported by the National Institute of Health, Tokyo, and the International Association of Biological Standardization : held at the Teijin Institute of Education and Training, Shizuoka, Japan, September 14-15, 1990. Karger, 1991.

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Rohani, Pejman, and Samuel Scarpino, eds. Pertussis. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198811879.001.0001.

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Pertussis, or whooping cough, is a respiratory disease caused primarily by infection with the bacterium Bordetella pertussis. It remains one of the leading causes of death among vaccine-preventable diseases worldwide and recent years have seen its alarming re-emergence in many regions (including the United States and much of Europe), despite sustained high levels of vaccine coverage. The causes of the resurgence remain contentious, in part due to inherent complexities of the pathogen’s biology, in part due to pronounced variation in the treatment and prevention strategies between different countries and regions, and in part due to long-standing disagreement among scientific researchers studying pertussis. This edited volume brings together expert knowledge from disparate fields with the overall aim of synthesizing the current understanding of this critically important, global pathogen. Pertussis: Epidemiology, Immunology, and Evolution is an advanced text suitable for graduate-level students taking courses in evolutionary epidemiology, disease ecology, and evolutionary biology, as well as academics, public health officials, and researchers in these fields. It also offers a very useful introduction to a wider audience of public health practitioners, microbiologists, epidemiologists, medical professionals, and vaccine biologists
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Tiru, M., Y. Sato, and H. Sato. Pertussis: Evaluation and Research on Acellular Pertussis Vaccines : Proceedings (Developments in Biologicals). S. Karger Publishers (USA), 1991.

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Book chapters on the topic "Bordetella Infections"

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Nieves, Delma J., and Ulrich Heininger. "Bordetella pertussis." In Emerging Infections 10. ASM Press, 2016. http://dx.doi.org/10.1128/9781555819453.ch17.

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Register, K., and E. Harvill. "Bordetella." In Pathogenesis of Bacterial Infections in Animals. Wiley-Blackwell, 2010. http://dx.doi.org/10.1002/9780470958209.ch21.

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Vogel, Frederick R. "Bordetella pertussis." In Pulmonary Infections and Immunity. Springer US, 1994. http://dx.doi.org/10.1007/978-1-4899-1063-9_9.

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Abe, Shigeru, Megumi Ohnishi, Sadao Kimura, et al. "BRM Activities of Low-Toxic Bordetella Pertussis Lipopolysaccharides." In Microbial Infections. Springer US, 1992. http://dx.doi.org/10.1007/978-1-4615-3434-1_8.

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Pittet, Laure F., and Klara M. Posfay-Barbe. "Bordetella holmesii: Still Emerging and Elusive 20 Years On." In Emerging Infections 10. ASM Press, 2016. http://dx.doi.org/10.1128/9781555819453.ch13.

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Gronthoud, Firza Alexander. "Bordetella pertussis." In Practical Clinical Microbiology and Infectious Diseases. CRC Press, 2020. http://dx.doi.org/10.1201/9781315194080-4-7.

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Stechenberg, Barbara. "Bordetella pertussis." In The Neurological Manifestations of Pediatric Infectious Diseases and Immunodeficiency Syndromes. Humana Press, 2008. http://dx.doi.org/10.1007/978-1-59745-391-2_16.

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Sinyashina, Ludmila N., Alisa Yu Medkova, Evgeniy G. Semin, Alexander V. Chestkov, Yuriy D. Tsygankov, and Gennagiy I. Karataev. "IS481-Induced Variability of Bordetella pertussis." In National Institute of Allergy and Infectious Diseases, NIH. Humana Press, 2008. http://dx.doi.org/10.1007/978-1-59745-569-5_24.

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Shahin, R. D., A. Kimura, J. Cowell, and C. R. Manclark. "Immunity to Bordetella pertussis in a mouse model of respiratory infection." In Advances in Mucosal Immunology. Springer Netherlands, 1990. http://dx.doi.org/10.1007/978-94-009-1848-1_259.

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Gillard, Joshua, Evi van Schuppen, and Dimitri A. Diavatopoulos. "Functional Programming of Innate Immune Cells in Response to Bordetella pertussis Infection and Vaccination." In Advances in Experimental Medicine and Biology. Springer International Publishing, 2019. http://dx.doi.org/10.1007/5584_2019_404.

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Conference papers on the topic "Bordetella Infections"

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Matsuda, T. "Kanpo Medicine (Japanese Traditional Medicine) Could Terminate Coughing Induced by Bordetella Pertussis and Bordetella Parapertussis Infection Within 2 Weeks." In American Thoracic Society 2020 International Conference, May 15-20, 2020 - Philadelphia, PA. American Thoracic Society, 2020. http://dx.doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a3908.

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Matsuda, T. "Early Detection of Bordetella Pertussis and Bordetella Parapertussis Infection with Pertussis Antibody Ig-M, Ig-A, and IgM/IgA Ratio." In American Thoracic Society 2019 International Conference, May 17-22, 2019 - Dallas, TX. American Thoracic Society, 2019. http://dx.doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a6161.

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Matsuda, T. "Epidemic of Bordetella Pertussis and Parapertussis Infection in Japan, Which Have Been Concomitant with Bronchial Asthma." In American Thoracic Society 2020 International Conference, May 15-20, 2020 - Philadelphia, PA. American Thoracic Society, 2020. http://dx.doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a6525.

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