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Dissertations / Theses on the topic 'Bordetella'

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Published: 4 June 2021
Last updated: 7 July 2024

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1

Ben, Hafsia Abdelhafidh. "Facteurs de virulence des bordetellae : le modèle de Bordetella parapertussis." Paris 11, 1991. http://www.theses.fr/1991PA114806.

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2

Phillips, Linda Jane. "Immunization against Bordetella pertussis." Thesis, Kansas State University, 1985. http://hdl.handle.net/2097/9871.

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3

Smith, Colin J. "Genetic studies with Bordetella pertussis." Thesis, University of Glasgow, 1986. http://theses.gla.ac.uk/1505/.

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4

Lewandowski, Anna Zofia. "Antigenic variation in Bordetella pertussis." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/MQ60480.pdf.

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5

Sidey, Fiona M. "Metabolic effects of Bordetella pertussis." Thesis, University of Strathclyde, 1987. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=20352.

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The present work confirmed that B. pertussis infection or pertussis toxin produce hypoglycaemia in mice. The hypoglycaemia was associated with hyperinsulinaemia, and both were abolished by destruction of the pancreatic β cells with alloxan. Impaired glucose counterregulatory mechanisms may also contribute to pertussis-induced hypoglycaemia, as the hypoglycaemic action of insulin was prolonged in pertussis infected mice. On the other hand, impaired responsiveness to lower doses of insulin was found. Pertussis-induced hyperinsulinaemia had two components. First, the increase in serum insulin in
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6

Ladant, Daniel. "L'adenyl cyclase de bordetella pertussis." Paris 7, 1989. http://www.theses.fr/1989PA077200.

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Bordetella pertussis, l'agent de la coqueluche secrete une adenyl cyclase qui constitue l'un des principaux facteurs de virulence de cet organisme. Cet enzyme bacterien presente l'originalite d'etre active par la calmoduline, une proteine regulatrice eucaryote. Nous avons purifie l'adenyl cyclase a l'homogeneite; elle possede l'activite specifique la plus elevee connue pour cette classe d'enzymes. Elle est constituee d'une chaine polypeptidique de 43-50 kilodaltons qui fixe une molecule de calmoduline avec une grande affinite. Par proteolyse limitee du complexe adenyl cyclase/calmoduline, nous
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7

Keidel, Kristina [Verfasser], and Roy [Akademischer Betreuer] Gross. "Charakterisierung des Hfq-Regulons in Bordetella pertussis und Bordetella bronchiseptica / Kristina Keidel. Betreuer: Roy Gross." Würzburg : Universitätsbibliothek der Universität Würzburg, 2011. http://d-nb.info/1018612696/34.

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8

GOYARD, SOPHIE. "Regulation de l'adenylcyclase de bordetella pertussis." Paris 6, 1993. http://www.theses.fr/1993PA066107.

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B. Pertussis, agent pathogene de la coqueluche, produit de nombreux facteurs de virulence dont la toxine adenylcyclase. Cet enzyme est active par une proteine eucaryote, la calmoduline ; particularite partagee avec une autre adenylcyclase bacterienne, celle de b. Anthracis, agent du charbon. Ces deux adenylcyclases comportent un motif peptidique hautement conserve que nous avons caracterise comme faisant partie du site catalytique de ces deux enzymes. Des anticorps diriges contre ce motif conserve nous ont permis de preciser une parente immunologique entre les deux adenylcyclases bacteriennes
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9

Al-Turkestany, Ismail M. A. "Interaction of Bordetella bronchiseptica and different Bordetella factors with sheep bone marrow mast cells and other cell types." Thesis, University of Glasgow, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.440331.

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10

Adams, Toni Elizabeth. "Bordetella bronchiseptica dermonecrotic toxin, purification and characterisation." Thesis, University of Leicester, 1997. http://hdl.handle.net/2381/29723.

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Dermonecrotic toxin (DNT) is produced by all the Bordetella species, and DNT from B. bronchiseptica is considered to be an important virulence factor in turbinate atrophy of pigs.;Recombinant DNT (rDNT) was purified by sonication, ion-exchange and hydroxylapatite chromatography. Other methods for the purification of wild-type DNT and rDNT, including preparative isoelectric focusing and hydrophobic chromatography, were investigated in detail.;Partially pure preparations of rDNT contained a 145 kDa protein band and were cytotoxic to embryonic bovine lung (EBL) cells. Partially pure rDNT induced
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11

Craig, Frank Furlong. "Effects of Bordetella pertussis on neutrophil leukocytes." Thesis, University of Glasgow, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.236023.

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12

Isobe, Tomoko. "Biosynthesis of inner-core LPS of Bordetella." Thesis, University of Cambridge, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.624405.

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13

Cambuy, Diego Duque. "Epidemiologia genômica de Bordetella pertussis no Brasil." reponame:Repositório Institucional da FIOCRUZ, 2014. https://www.arca.fiocruz.br/handle/icict/13349.

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Made available in DSpace on 2016-03-28T12:41:00Z (GMT). No. of bitstreams: 2 diego_cambuy_ioc_mest_2014.pdf: 2689625 bytes, checksum: 9a0d86cf1fe73771c946b0bd687aec4b (MD5) license.txt: 1748 bytes, checksum: 8a4605be74aa9ea9d79846c1fba20a33 (MD5) Previous issue date: 2015-04-14<br>Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil<br>A coqueluche, ou pertússis, é uma doença do trato respiratório causada principalmente pela bactéria Bordetella pertussis. Após 50 anos de vacinação, pertussis reemergiu, passando a ser a doença imunoprevinível mais frequente mesmo em pa
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14

Colombi, Débora. "Clonagem e expressão da Região Hep do domínio de Heparina da Proteína hemaglutinina filamentosa ( FHA) da bactéria Bordella pertussis em sistemas heterólogos." Universidade de São Paulo, 2003. http://www.teses.usp.br/teses/disponiveis/46/46131/tde-13112014-173027/.

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Bordetella pertussis, o agente etiológico da coqueluche ou tosse comprida, que estabelece a infecção através da fixação bacteriana no epitélio do trato respiratório superior. Os principais mediadores de adesão da bactéria são a toxina pertússica (PT) e a hemaglutinina filamentosa (FHA). A FHA é a adesina majoritária e contém pelo menos 4 domínios: porção Nterminal, domínio de reconhecimento de carboidrato (CRD) (FHA1141-1279), trinca de aminoácidos Arginina-Glicina-Ácido aspártico (RGD) (FHA1097-1099) e o sítio de ligação a heparina (domínio Hep) (FHA442-863). Neste trabalho, foi realizado a a
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15

Hegerle, Nicolas. "Evolution of Bordetella pertussis and Bordetella parapertussis under acellular Pertussis vaccine pressure : What future for whooping cough and Pertussis vaccination ?" Paris 7, 2014. http://www.theses.fr/2014PA077038.

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La coqueluche est une maladie respiratoire dangereuse pour les nouveaux nés non vaccinés. Celle-ci est causée par Bordetella pertussis et Bordetella parapertussis, deux bactéries à gram négatif dont le seul hôte connu est l'homme. L'introduction de la vaccination contre B. Pertussis, le pathogène majoritairement responsable de cette maladie, à grandement impacté l'épidémiologie de la coqueluche ainsi que les populations de B. Pertussis circulant dans la population humaine. Les premier vaccins introduit dans les 1950 et utilisés pour la primo vaccination et le rappel enfant, dit à germes entier
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16

Stenson, Trevor H. "Characterization of Bvg-repressed molecules of Bordetella pertussis." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ34841.pdf.

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17

Sims, Peter Vincent. "Biogenesis of BapF : a novel acylated Bordetella autotransporter." Thesis, University of British Columbia, 2012. http://hdl.handle.net/2429/41811.

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Autotransporters are a superfamily of Gram-negative secreted proteins, composed of a Cterminal domain which forms a β-barrel in the outer membrane and plays a significant role in translocation of the N-terminal passenger domain to the cell surface. A subfamily of autotransporters is N-terminally acylated during their biogenesis, a post-translational modification demonstrated to be essential for their function. Considering the autotransporter passenger domain is secreted beyond the outer membrane, how translocation can occur in the presence of N-terminal acyl groups is undetermined. The work in
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18

King, Jerry David. "Characterisation of polysaccharide biosynthesis genes in Bordetella bronchiseptica." Thesis, University of Cambridge, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.614163.

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19

Glaser, Philippe. "Biologie moleculaire de l'adenylate cyclase de bordetella pertussis." Paris 6, 1988. http://www.theses.fr/1988PA066259.

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Bordella pertussis, agent etiologique de la coqueluche, synthetise, entre autres toxines, une adenylate cyclase dont l'activite depend d'une proteine de l'hote, la calmoduline. Clonage et structure du geni de l'adenylate cyclase (gene cya) ont ete realises par complementation d'une souche cya d escherichia coli, en reconstituant la bacterie l'activation par la calmoduline. L'adenylate cyclase et synthetisee sous forme d'un precurseur bifonctionnel de haut poids moleculaires
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20

Glaser, Philippe. "Biologie moléculaire de l'adénylate cyclase de Bordetella pertussis." Grenoble 2 : ANRT, 1988. http://catalogue.bnf.fr/ark:/12148/cb376139521.

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21

Neal, Shona Elaine. "Genotypic diversity and epidemiological typing of Bordetella pertussis." Thesis, University of Glasgow, 2004. http://theses.gla.ac.uk/30856/.

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The resurgence of pertussis in several highly vaccinated countries has stimulated this study of the genotypic diversity and epidemiological typing of Bordetella pertussis. The genotypic variation of B. pertussis was investigated in 318 UK clinical isolates from 1920-2002, vising pertactin (prnA) and pertussis toxin SI subunit (ptxA) gene typing. To date, the evaluation of typing methods used for B. pertussis has not been performed extensively. Therefore, in this thesis, the recognised methods, namely serotyping, pulsed-field gel electrophoresis (PFGE) using Xbal, and IS1002-RFLP analysis, were
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22

Dill, Michael T. "Characterization of the Aspartate Transcarbamoylase that is Found in the pyrBC’ Complex of Bordetella Pertussis." Thesis, University of North Texas, 2001. https://digital.library.unt.edu/ark:/67531/metadc3057/.

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An aspartate transcarbamoylase (ATCase) gene from Bordetella pertussis was amplified by PCR and ligated into pT-ADV for expression in Escherichia coli. This particular ATCase (pyrB) was an inactive gene found adjacent to an inactive dihydroorotase (DHOase) gene (pyrC'). This experiment was undertaken to determine whether this pyrB gene was capable of expression alone or if it was capable of expression only when cotransformed with a functional pyrC'. When transformed into E. coli TB2 pyrB-, the gene did not produce any ATCase activity. The gene was then co-transformed into E. coli TB2 p
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23

Rivera-Millot, Alex. "Mécanismes de l’homéostasie du cuivre chez un pathogène strictement humain, Bordetella pertussis." Thesis, Lille 2, 2020. http://www.theses.fr/2020LIL2S009.

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Le cuivre est devenu un élément essentiel à la plupart des organismes vivants depuis l’apparition de l’oxygène dans l’atmosphère terrestre il y a 2,7 milliards d’années. Ce métal est utilisé dans de nombreux processus biologiques, mais les propriétés chimiques qui le rendent indispensable sont également à l’origine de sa toxicité. Cette ambivalence du cuivre a fait que tous les organismes ont développé divers systèmes permettant un maintien extrêmement strict de l’homéostasie de ce métal. Certains organismes comme les amibes ont également mis à profit ses propriétés toxiques pour la prédation
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24

Gerlach, Gabriele. "Funktionelle Charakterisierung des BvgASBH-Zwei-Komponentensystems von Bordetella holmesii." [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=973411678.

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25

Tefon, Burcu Emine. "Towards Whole Cell Immunoproteome And Subproteomes Of Bordetella Pertussis." Phd thesis, METU, 2012. http://etd.lib.metu.edu.tr/upload/12614238/index.pdf.

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Bordetella pertussis is a gram-negative, human pathogen and etiologic agent of whooping cough (pertussis), a highly contagious, acute respiratory illness. In this study, the analysis of whole immunproteome and subproteomes of this microorganism was performed. The soluble cytoplasmic proteomes of B. pertussis Tohama I strain and a local isolate Saadet were separated by 2DE. By Western blot analysis, we identified 25 immunogenic proteins of three categories. In the first group, there were well-known proteins of the pathogen The second group comprised proteins which were already shown antigenic i
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26

Bokhari, Syed Habib. "Characterisation and secretion mechanism of Bordetella pertussis autotransporter proteins." Thesis, University of Glasgow, 2002. http://theses.gla.ac.uk/1507/.

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The identification and characterisation of new virulence determinants of 5. pertussis is providing important information for understanding the colonisation and survival strategies of the microorganism. B. pertussis deploys a range of surface-associated components to enable its successful colonisation of the host. Bap-5 has been identified as a new member of the B. pertussis autotransporter family of proteins that includes PRN, BrkA, TCF and Vag-8, largely due to its homology at the C-terminus and some other similar regions such as the RGD (integrin-binding) and SGXG (glycosaminoglycan-binding)
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27

Garrod, Tracey. "Partial purification and characterisation of Bordetella bronchiseptica dermonecrotic toxin." Thesis, University of Reading, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.239514.

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28

Funnell, Simon Gordon Paul. "Mechanisms of colonisation of mammalian tissues by Bordetella pertussis." Thesis, Open University, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.239726.

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29

Pearce, Alexandra M. "The structure and immunogenicity of fimbriae from Bordetella pertussis." Thesis, Open University, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.333436.

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30

Li, Jing-Li. "A molecular study of virulence factors of Bordetella species." Thesis, Open University, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.303193.

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A 1kb HinfI DNA fragment, containing a repeat DNA sequence element was isolated from a Bordetella pertussis BP348 cosmid gene bank. This repeat DNA sequence has subsequently been named IS148. The insertion sequence was demonstrated by have a high copy number only in B.pertissus and to be absent in Bordetella parapertussis and Bordetella bronchiseptica. Using a restriction fragment of IS148 labelled with radioactivity as a probe in DNA or whole cell dot blots between 10-100 cells could be detected or from 100pb-1ng DNA. Furthermore, a pair of oligonucleotide primers was synthesised correspondin
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31

Bassinet, Laurence. "Bordetella pertussis et épithélium respiratoire : aspects biologiques et cliniques." Paris 12, 2004. https://athena.u-pec.fr/primo-explore/search?query=any,exact,990003948590204611&vid=upec.

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La coqueluche, infection des voies aériennes inférieures par Boedetella pertussis (Bp), est en recrudescence chez les adultes qui contaminent les nouveaux-nés exposés aux formes sévères de la maladie. Nous rapportons une épidémie de coqueluche parmi les membres du personnel soigant (MPS) d'un hôpital avec contamination de 2 patients adultes. Ces données font discuter une vaccination des MPS. Les interactions de l'hépithélium respiratoire humain avec Bp ont été étudiées dans le but initial de rechercher un réservoir bactérien chez l'adulte. Nous avons montré que Bp pénètre dans des cellules épi
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32

Bassinet, Laurence Guiso-Maclouf Nicole. "Bordetella pertussis et épithélium respiratoire aspects biologiques et cliniques /." Créteil : Université de Paris-Val-de-Marne, 2007. http://doxa.scd.univ-paris12.fr:8080/theses-npd/th0394859.pdf.

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Thèse de doctorat : Sciences de la vie et de la santé. Biologie cellulaire et moléculaires des épithéliums : Paris 12 : 2004.<br>Version électronique uniquement consultable au sein de l'Université Paris 12 (Intranet). Titre provenant de l'écran-titre. Bibliogr. : 332 réf.
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33

Rambow-Larsen, Amy Alison. "Assembly and secretion of pertussis toxin by bordetella pertussis." Cincinnati, Ohio : University of Cincinnati, 2003. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=ucin1066417734.

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34

Fong, Winkie Wing Kei. "Genomics and Metagenomics of Bordetella species for Disease Control." Thesis, The University of Sydney, 2020. https://hdl.handle.net/2123/25040.

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Pertussis is a vaccine preventable disease, primarily caused by the bacterium Bordetella pertussis (and occasionally B. holmesii and B. parapertussis). The disease is highly contagious, and results in extended periods of coughing. Prior to vaccination, pertussis was the foremost cause of infantile death by infection globally. Global vaccination efforts against pertussis were introduced in the 1950s and this resulted in the rate of pertussis infections to decrease tremendously. In recent decades, public health authorities around the world have reported a resurgence of the number of pertussis ca
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35

Hormozi, E. Kalantar. "Activation and immunogenicity of Bordetella pertussis adenylate cyclase toxin." Thesis, University of Glasgow, 1997. http://theses.gla.ac.uk/30948/.

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Adenylate cyclase toxin (CyaA) was produced and purified in the toxic CyaC-modified form and the unmodified non-toxic form from both B. pertussis and recombinant E. coli strains in sufficient quantity to allow large scale experimentation. Immunoblot analysis of crude and purified CyaA preparations revealed that the toxins were prepared as full length 200 kDa proteins with a small amount of degradation products of lower molecular weight protein in both toxic and non-toxic forms. The in vivo CyaC-modified CyaA toxin produced from recombinant E. coli showed comparable levels of cytotoxic and inva
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36

Pavic, Espinoza Ivana, Medina Sandy Bendezu, Alzamora Angella Herrera, Maria J. Pons, Adrian V. Hernández, Valle Mendoza Juana Mercedes Del, and Universidad Peruana de Ciencias Aplicadas (UPC). "High prevalence of Bordetella pertussis in severe acute respiratory infections in hospitalized children under 5 years in Lima, Peru." Universidad Peruana de Ciencias Aplicadas (UPC), 2015. http://hdl.handle.net/10757/582376.

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ASTMH 64th Annual Meeting. October 25-29, 2015 Philadelphia Marriott Downtown Philadelphia, Pennsylvania USA<br>Acute respiratory infections (ARI) are the main cause of morbidity and mortality in children under 5 years worldwide. Bordetella pertussis is a highly contagious bacterium that can cause serious illness, and approximately half of infected infants less than 1 year old are hospitalized. Also, pertussis immunization series is not completed until six months of age, leaving young infants vulnerable to pertussis. In Peru, pertussis is an increasing health problem despite immunization eff
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37

Mir, Cros Alba. "Dinàmica poblacional i deriva antigènica de Bordetella pertussis i el paper d’altres espècies del gènere Bordetella en l’emergència de la tosferina al segle XXI." Doctoral thesis, Universitat Autònoma de Barcelona, 2021. http://hdl.handle.net/10803/673654.

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La tosferina és una malaltia infecciosa aguda causada generalment per Bordetella pertussis, un cocbacil gramnegatiu, de reservori exclusivament humà i amb una elevada transmissibilitat per via aèria. Es caracteritza per presentar un quadre respiratori de tos intensa que, sovint, pot perllongar-se durant setmanes o mesos. Entre les possibles causes implicades en el ressorgiment de la tosferina, destaca l’adaptació de B. pertussis a la immunitat conferida per les vacunes acel·lulars (DTPa), les quals es van introduir en el nostre entorn a finals dels anys noranta, així com l’emergència de noves
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38

Iscan, Elvin. "Analysis Of Cross-immune Reaction Between Strains Of Bordetella Pertussis." Master's thesis, METU, 2009. http://etd.lib.metu.edu.tr/upload/12611359/index.pdf.

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Bordetella pertussis is the causative agent of whooping cough which is a worldwide acute respiratory disease that predominantly involves infants. Whooping cough is one of the ten most common causes of death from infectious diseases worldwide. The increased coverage of the primary pertussis vaccination (DaBT-IPA-Hib) decreased the incidence of disease in Turkey dramatically. However, in spite of the incidence decline, the circulation of B. pertussis has not yet been eliminated, and a change in the clinical spectrum and age-related incidence of the disease has been observed. On the other hand, i
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39

Al-Fellah, Giamal Nouri. "Inactivation of Bordetella pertussis by rat lung lavage fluids (LLF)." Thesis, University of Glasgow, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.263427.

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40

Brotherston, Christopher. "Interaction of Bordetella pertussis adenylate cyclase toxin with target cells." Thesis, University of Glasgow, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.263429.

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41

Binns, Sarah Helen. "Studies on the epidemiology of Bordetella bronchiseptica infection in cats." Thesis, University of Liverpool, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.243267.

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42

ZARROUK, HASSAN. "Etude de la structure d'endotoxines de bacteries du genre bordetella." Paris 11, 1998. http://www.theses.fr/1998PA112051.

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Les endotoxines sont des constituants heterogenes majeurs de la paroi des bacteries a gram negatif. Elles sont composees de trois regions principales dont la structure generale et les voies de biosynthese sont differentes : (i) le lipide a generalement, constitue d'un disaccharide de glucosamines reliees par une liaison 1-6, contient des groupes phosphates et des acides gras ; (ii) le noyau oligosaccharidique compose d'une dizaine de residus osidiques et (iii) les chaines-o specifiques formees par des unites repetitives portant les determinants antigeniques. L'importance de ces lipopolysacchar
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43

Hettiarachchige, Amali. "Detection of Bordetella Infection in a Paediatric Population at CHW." Thesis, The University of Sydney, 2015. http://hdl.handle.net/2123/14872.

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Detection of Bordetella Infection in a Paediatric Population at CHW Hettiarachchige ANP1*, Kesson AM1, Leung KC2 Department of Infectious Diseases and Microbiology. The Children’s Hospital at Westmead. Discipline of Paediatrics and Child health, University of Sydney, Sydney, Australia. Introduction The Bordetella bacteria, such as B. pertussis, B. parapertussis and B. holmesii, are causative agents of whooping cough in humans. While B. pertussis is well documented to be an important agent of this disease in Australia, the roles of B. parapertussis and B. holmesii are unknown. To address thi
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44

Leusch, Mark Steven. "Purification and characterization of adenylate cyclase toxin from Bordetella pertussis." Diss., The University of Arizona, 1990. http://hdl.handle.net/10150/184998.

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Bordetella pertussis produces a number of virulence determinants believed to contribute to its survival in the host as well as to the pathogenesis of disease. One of these factors, adenylate cyclase toxin (ACT), has been implicated to penetrate human neutrophils and macrophages and abrogate their function by virtue of unregulated production of intracellular cAMP. In order to adequately study the nature of ACT and its role in pathogenesis, it is necessary to isolate the toxin from other virulence factors produced by the organism. Attempts by other investigators to purify ACT and maintain both i
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45

Steed, Lisa Lovett. "Host-parasite interactions between Bordetella pertussis and human polymorphonuclear leukocytes." Diss., The University of Arizona, 1991. http://hdl.handle.net/10150/185641.

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Little is known regarding the interaction of Bordetella pertussis with polymorphonuclear leukocytes (PMNL) or the role PMNL play as an initial line of defense against B. pertussis infection. An in vitro system was developed to establish optimum conditions for the study of phagocytosis and killing of three virulent strains of B. pertussis and a series of derivative mutants using strictly human PMNL and sera. Optimum phagocytosis of B. pertussis occurred by opsonization with human anti-B. pertussis antibody (HAPA), while autologous normal sera (NS) did not induce significant phagocytosis. An ant
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46

Edwards, Jessica. "Initial Interactions between Bordetella bronchiseptica and Tracheal Epithelial Cell Cilia." Diss., The University of Arizona, 2006. http://hdl.handle.net/10150/195708.

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The Bordetella genus contain primary colonizing bacteria of the mammalian respiratory tract. Bordetella bind specifically to cilia and colonize the healthy conducting airway epithelium. In this dissertation, I examine the following aspects of initial Bordetella/ciliary binding: 1) the contribution of individual Bordetella virulence factors to binding, 2) the identity of ciliary receptors for Bordetella, and 3) the contribution of airway epithelial innate immune effectors in defense against Bordetella colonization. Bordetella/host cell interactions are modeled using Bordetella bronchiseptica a
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47

Felizardo, Maria Roberta. "Isolamento e caracterização de amostras de Bordetella bronchiseptica através da eletroforese em gel de campo pulsado (PFGE)." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/10/10134/tde-13032012-140016/.

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Bordetella bronchiseptica é um dos agentes etiológicos da tosse dos canis, infecções do trato respiratório superior em gatos, rinite atrófica, broncopneumonia em suínos, sendo freqüentemente isolada em coelhos e animais de laboratório. O impacto deste agente em saúde humana ainda é subestimado, o risco da infecção de pessoas imunodeprimidas que tem contato com animais domésticos existe e é relatado na literatura. No Brasil não há estudos caracterizando o agente isolado a partir de espécies de animais de companhia. O conhecimento dos aspectos epidemiológicos da infecção por Bordetella bronchise
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48

Herrou, Julien. "Etude du régulateur central de la virulence, BvgA/S, chez Bordetella pertussis, l'agent de la coqueluche." Lille 2, 2008. http://www.theses.fr/2008LIL2S038.

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La régulation de la virulence chez Bordetella pertussis, l'agent de la coqueluche, est sous la dépendance d'un système à deux composants complexe appelé BvgA/S. Ce système est composé d'une protéine senseur membranaire appelée BvgS et d'un régulateur transcriptionnel cytoplasmique, BvgA. En présence d'activateurs de la virulence (non encore définis), BvgS s'autophosphoryle, l'accepteur terminal du phosphate étant BvgA qui est alors actif et va réguler la transcription des gènes impliqués dans la virulence. Par contre, lorsque la bactérie est en présence d'inhibiteurs de la virulence, comme l'a
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49

Lechner, Melanie. "Charakterisierung des Umweltkeims Bordetella petrii : Untersuchungen zur genomischen Variabilität und zum Bvg Regulon." kostenfrei, 2008. http://www.opus-bayern.de/uni-wuerzburg/volltexte/2009/3439/.

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50

Pons, Maria J., Cl觃udia Gomes, Carlos Bada, Isabel Reyes, Valle Mendoza Juana Del, and Joaquim Ruiz. "Characterization of two Achromobacter xylosoxidans isolates from patients with pertussis-like symptoms." Elsevier B.V, 2015. http://hdl.handle.net/10757/554305.

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joruiz@clinic.ub.es<br>Objective: To characterize two Achromobacter xylosoxidans recovered from 2 patients diagnosed with pertussis during a Bordetella pertussis surveillance program. Methods: Nasopharyngeal swabs from 2 children under 1 year of age with clinical suspicion of pertussis were analyzed by culture and PCR. Results: Two Achromobacter xylosoxidans A8, closely related to Bordetella spp. were recovered from 2 patients diagnosed of pertussis, both carrying the ptxA gene and IS418 the pertussis toxin encoding gene. Subsequently, antibiotic susceptibility was evaluated by disk-diff
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