Academic literature on the topic 'Boronic Acids/pharmacology'

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Journal articles on the topic "Boronic Acids/pharmacology"

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Arvanitis, Costa, Trevor Rook, and Ian Macreadie. "Mechanism of Action of Potent Boron-Containing Antifungals." Current Bioactive Compounds 16, no. 5 (2020): 552–56. http://dx.doi.org/10.2174/1573407215666190308152952.

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Background: Boron is unusual to organic chemists, yet boron interacts greatly with organic biochemicals and has considerable bioactivity, especially as an antifungal and insecticide. The bestknown bioactive boron compounds are boric acid, its salt borax, and the closely related boronic acids. A newcomer is tavaborole (trade name Kerydin), recently developed and approved in 2014 for topical treatment of onychomycosis, a fungal infection of nails and the nail bed. It is timely to review the literature and explore the way in which these compounds may work. Methods: The focus of this review is to
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Han, Young Taek. "A Concise Synthesis of Rhodanthpyrone A and B, Natural 4-(Hydroxyphenyl)-substituted α-Pyrones". Natural Product Communications 12, № 1 (2017): 1934578X1701200. http://dx.doi.org/10.1177/1934578x1701200127.

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A concise synthesis of rhodanthpyrone A and B was accomplished via a Suzuki coupling reaction. To find the conditions appropriate to install hydroxyphenyl moieties to the α-pyrone skeleton, a model study was conducted using commercially available boronic acids. It was revealed that the hydroxy moiety of the phenylboronic acids should be concealed when reacted with labile 4-tosyl α-pyrone. Consequently, rhodanthpyrone A and B could be synthesized in high yields by Suzuki reaction using TIPS-protected arylboronic acids. This procedure provided a concise and versatile route for the synthesis of r
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Bassini, Emanuele, Stefano Gazzotti, Filomena Sannio та ін. "Isonitrile-Based Multicomponent Synthesis of β-Amino Boronic Acids as β-Lactamase Inhibitors". Antibiotics 9, № 5 (2020): 249. http://dx.doi.org/10.3390/antibiotics9050249.

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The application of various isonitrile-based multicomponent reactions to protected (2-oxoethyl)boronic acid (as the carbonyl component) is described. The Ugi reaction, both in the four components and in the four centers–three components versions, and the van Leusen reaction, proved effective at providing small libraries of MIDA-protected β-aminoboronic acids. The corresponding free β-aminoboronic acids, quantitatively recovered through basic mild deprotection, were found to be quite stable and were fully characterized, including by 11B-NMR spectroscopy. Single-crystal X-ray diffraction analysis
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Bosch, Eric, and Nate Schultheiss. "Facile Synthesis of Diarylpyrazines Using Suzuki Coupling of Dichloropyrazines with Aryl Boronic Acids." HETEROCYCLES 60, no. 8 (2003): 1891. http://dx.doi.org/10.3987/com-03-9789.

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Hayama, Noboru. "Asymmetric Hetero-Michael Additions to α,β-Unsaturated Carboxylic Acids by Multifunctional Boronic Acid Catalysts". YAKUGAKU ZASSHI 141, № 3 (2021): 293–301. http://dx.doi.org/10.1248/yakushi.20-00214.

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Matteson, Donald S. "α-Amido boronic acids: A synthetic challenge and their properties as serine protease inhibitors". Medicinal Research Reviews 28, № 2 (2007): 233–46. http://dx.doi.org/10.1002/med.20105.

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Kumar, Sandeep, and Arvind M. Kayastha. "Inhibition studies of soybean (Glycine max) urease with heavy metals, sodium salts of mineral acids, boric acid, and boronic acids." Journal of Enzyme Inhibition and Medicinal Chemistry 25, no. 5 (2009): 646–52. http://dx.doi.org/10.3109/14756360903468155.

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Hargrove, Amanda E., Andrew D. Ellington, Eric V. Anslyn, and Jonathan L. Sessler. "Chemical Functionalization of Oligodeoxynucleotides with Multiple Boronic Acids for the Polyvalent Binding of Saccharides." Bioconjugate Chemistry 22, no. 3 (2011): 388–96. http://dx.doi.org/10.1021/bc100376x.

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Boyd, Derek R., Narain D. Sharma, Peter A. Goodrich, et al. "Enantiopurity and absolute configuration determination of arenecis-dihydrodiol metabolites and derivatives using chiral boronic acids." Chirality 30, no. 1 (2017): 5–18. http://dx.doi.org/10.1002/chir.22764.

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Gorovoy, Alexey S., Olga Gozhina, John-Sigurd Svendsen та ін. "Syntheses and anti-tubercular activity ofβ-substituted andα,β-disubstituted peptidylβ-aminoboronates and boronic acids". Journal of Peptide Science 19, № 10 (2013): 613–18. http://dx.doi.org/10.1002/psc.2537.

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Dissertations / Theses on the topic "Boronic Acids/pharmacology"

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Malan, Christophe. "Synthèse de dérivés bores pour la boroneutrothérapie." Université Joseph Fourier (Grenoble), 1997. http://www.theses.fr/1997GRE10124.

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Dans ce travail, la synthese d'acides alpha-amines bores tels que la borophenylalanine-compose actuellement en essais cliniques chez l'homme pour le traitement des melanomes par boroneutrotherapie- et divers de ses analogues a ete abordee. Diverses approches d'une synthese stereospecifique de la l-borophenylalanine (ce qui n'avait jamais ete realise auparavant), ont ete envisagees. La premiere, dont l'etape clef repose sur une reaction de couplage entre un organozincique chiral derive de la l-serine et un iodure aromatique bore, a permis d'obtenir la l-borophenylalanine optiquement pure. La de
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