Relevant bibliographies by topics / Bose gla

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Bose gla'

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Published: 10 March 2023

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Journal articles on the topic "Bose gla"

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Miura, Yoshiaki, Takeshi Ishiyama, Masanosuke Nagao, Hian In, Masao Kitaoka, Kazuhiko Ohara, Masaaki Arakawa, Hideaki Takahashi, and Ryuichi Kasai. "Serum levels of bone Gla-protein." Journal of Japanese Society for Dialysis Therapy 21, no. 9 (1988): 861–70. http://dx.doi.org/10.4009/jsdt1985.21.861.

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Price, Paul A. "Gla-Containing Proteins of Bone." Connective Tissue Research 21, no. 1-4 (January 1989): 51–60. http://dx.doi.org/10.3109/03008208909049995.

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OBRANT, KARL J., BLANDINE MERLE, JACQUES BEJUI, and PIERRE D. DELMAS. "Serum Bone-Gla Protein After Fracture." Clinical Orthopaedics and Related Research &NA;, no. 258 (September 1990): 300???303. http://dx.doi.org/10.1097/00003086-199009000-00035.

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Pastoureau, P., B. Merle, and P. D. Delmas. "Specific radioimmunoassay for ovine bone gla-protein (osteocalcin)." Acta Endocrinologica 119, no. 1 (September 1988): 152–60. http://dx.doi.org/10.1530/acta.0.1190152.

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Abstract. We developed a sensitive and specific radioimmunoassay for ovine bone gla-protein (osteocalcin) using a polyclonal rabbit antibody raised against ovine bone gla-protein. Bone from lambs was extracted in 0.5 mol/l EDTA and desalted on Sephadex G-25. Bone gla-protein was purified by gel filtration chromatography over Sephadex G-100 and ion-exchange chromatography on DEAE-Sephadex A-25. The protein, subjected to monodimensional electrophoresis migrated as a single spot in SDS PAGE with the same apparent molecular weight of 12 kD as bovine bone gla-protein. The amino acid composition of purified bone gla-protein was in agreement with a previous publication. The competitive RIA uses 125I-labelled bone gla-protein as a tracer and a complex of a second antibody and polyethylene glycol to separate free and antibody-bound 125I-labelled bone gla-protein. The intra- and inter-assay variations are less than 6 and 10%, respectively. There is no reactivity of our antisera with dog sera. The cross-reactivity is only partial with calf and human sera and complete with ovine sera. We measured bone gla-protein levels in serum of 96 normal male sheep of different ages. Serum bone gla-protein rapidly and significantly (P <0.001) decreased from 535 ± 169 μg/l at birth, to 240 ± 43 μg/l at 45 days, 152 ± 44 μg/l at 90 days, and 5.9 ± 0.7 μg/l at 7 years of age. In addition, bone gla-protein levels at birth were higher in normal birth weight than in hypotrophic lambs with low birth weight (535 ± 169 vs 271 ± 156 μg/l, P< 0.001). Furthermore, lambs raised outside in free conditions tended to have higher serum bone gla-protein levels than lambs raised under shelter (194 ± 53 vs 137 ± 34 μg/l), suggesting a role of breeding factors such as diet or relative immobilization on bone gla-protein levels. These results emphasize the interest of a RIA for the bone-specific protein bone gla-protein as a potential tool for experimental studies on skeletal growth and bone remodelling in a large animal.
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Johnson, Teresa L., Alan Y. Sakaguchi, Peter A. Lalley, and Robin J. Leach. "Chromosomal assignment in mouse of matrix Gla protein and bone Gla protein genes." Genomics 11, no. 3 (November 1991): 770–72. http://dx.doi.org/10.1016/0888-7543(91)90089-w.

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Kaipatur, N. R., M. Murshed, and M. D. McKee. "Matrix Gla Protein Inhibition of Tooth Mineralization." Journal of Dental Research 87, no. 9 (September 2008): 839–44. http://dx.doi.org/10.1177/154405910808700907.

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Extracellular matrix (ECM) mineralization is regulated by mineral ion availability, proteins, and other molecular determinants. To investigate protein regulation of mineralization in tooth dentin and cementum, and in alveolar bone, we expressed matrix Gla protein (MGP) ectopically in bones and teeth in mice, using an osteoblast/odontoblast-specific 2.3-kb Col1a1 promoter. Mandibles were analyzed by radiography, micro-computed tomography, light microscopy, histomorphometry, and transmission electron microscopy. While bone and tooth ECMs were established in the Col1a1-Mgp mice, extensive hypomineralization was observed, with values of unmineralized ECM from four- to eight-fold higher in dentin and alveolar bone when compared with that in wild-type tissues. Mineralization was virtually absent in tooth root dentin and cellular cementum, while crown dentin showed “breakthrough” areas of mineralization. Acellular cementum was lacking in Col1a1-Mgp teeth, and unmineralized osteodentin formed within the pulp. These results strengthen the view that bone and tooth mineralization is critically regulated by mineralization inhibitors.
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Thomsen, K., E. F. Eriksen, J. C. R. Jørgensen, P. Charles, and L. Mosekilde. "Seasonal variation of serum bone GLA protein." Scandinavian Journal of Clinical and Laboratory Investigation 49, no. 7 (November 1, 1989): 605–11. http://dx.doi.org/10.3109/00365518909091535.

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Thomsen, K., E. F. Eriksen, J. C. R. Jørgensen, P. Charles, and L. Mosekilde. "Seasonal variation of serum bone GLA protein." Scandinavian Journal of Clinical and Laboratory Investigation 49, no. 7 (January 1989): 605–11. http://dx.doi.org/10.1080/00365518909091535.

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Bataille, Régis, Pierre Delmas, and Jacques Sany. "Serum bone gla-protein in multiple myeloma." Cancer 59, no. 2 (January 15, 1987): 329–34. http://dx.doi.org/10.1002/1097-0142(19870115)59:2<329::aid-cncr2820590227>3.0.co;2-s.

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Delmas, P. D., C. Christiansen, K. G. Mann, and P. A. Price. "Bone gla protein (osteocalcin) assay standardization report." Journal of Bone and Mineral Research 5, no. 1 (January 1990): 5–11. http://dx.doi.org/10.1002/jbmr.5650050104.

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Dissertations / Theses on the topic "Bose gla"

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Terpening, Christopher Miles. "Analysis of transcriptional regulation of the rat bone gla protein gene by 1,25-dihydroxyvitamin D3: Receptor biochemistry and gene interactions." Diss., The University of Arizona, 1991. http://hdl.handle.net/10150/185381.

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The secosteroid hormone 1, 25-dihydroxyvitamin D₃ (1,25(OH)₂D₃) exerts its effects through a receptor protein which is a member of a superfamily of steroid receptor proteins. The 1,25(OH)₂D₃ receptor protein (VDR) binds both hormone and DNA with high affinity , thereby transcriptionally regulating the expression of a number of genes. A fragment of the cDNA to the human VDR containing essentially the entire open reading frame was transcribed and translated in vitro. demonstrated to exhibit The resulting protein was then the physical and functional features, i.e. molecular weight, immunoreactivity, 1,25(OH)₂D₃ binding, and DNA-cellulose binding, of the native human receptor from the T47D cell line. This validates the authenticity of the cDNA in a cell free system and provides a biochemical means of generating this rare and labile macromolecule to use in heretofore difficult structure/function studies. The gene for rat bone gla protein (BGP) was isolated and 1250 bp including 1100 bp of 5' flanking DNA were placed upstream of the human growth hormone reporter gene. Following transient transfection into the osteoblast-like rat osteosarcoma cell line, ROS 17/2.8, the BGP promoter demonstrated a low level of basal activity that was increased approximately ten-fold by addition of 10⁻⁸ M 1,25(OH)2D3. A single 249 bp fragment (-523 to -274) was sufficient to confer hormone inducibility upon both heterologous and homologous promoters. Deletion studies, complemented by evaluation with synthetic oligomers, enabled localization of the 1,25(OH)₂D₃ response element (VDRE) to within 19 bp (-456 to -438), containing an element with an imperfect direct repeat (GGTGA(N₄)GGACA) and homology to other steroid responsive elements. This enhancer element was capable of strong synergism when present in multiple copies. Gel retardation assays demonstrated that partially purified VDR from chicken or rat bound specifically and with high affinity to a DNA fragment containing the putative VDRE and this binding was perturbed by monoclonal antibodies to the VDR. surprisingly, the 249 bp fragment, when linked in an antisense orientation with respect to the BGP promoter, blocked the basal and hormone dependent gene expression. However, a 245 bp fragment 5' to the 249 bp element (-1100 to -855) restored 20-fold inducibility when linked to the first fragment in the same orientation. The presence or absence of this distal element also modulated the 1,25(OH)₂D₃ response within the milieu of the native gene. Thus, the VDRE apparently cooperates with other elements to achieve the hormonal response observed in this gene.
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Priller, Josef. "Glia und hämatopoetische Zellen im zentralen Nervensystem." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2002. http://dx.doi.org/10.18452/13816.

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Gentherapie und Zellersatz im zentralen Nervensystem (ZNS) werden durch die Blut-Hirn-Schranke behindert, die den Übertritt von Plasmabestandteilen und Zellen in das ZNS limitiert. Genetisch modifizierte Knochenmarkszellen können jedoch ungeachtet der intakten Blut-Hirn-Schranke in das ZNS einwandern und dort zu Mikroglia differenzieren. Neurone signalisieren eine Schädigung an benachbarte Glia und rekrutieren Zellen hämatopoetischen Ursprungs gezielt an den Ort der Läsion. Aus adulten Stammzellen des Knochenmarks können schliesslich Nervenzellen entstehen, die in die komplexe Architektur des ZNS integriert werden. Die Befunde liefern neue Ansätze für die Therapie von ZNS-Erkrankungen.
Gene therapy and cell replacement strategies in the central nervous system (CNS) are hindered by the presence of the blood-brain barrier, which restricts access of serum constituents and peripheral cells to the CNS. Genetically modified bone marrow-derived cells are capable of entering the CNS in spite of the blood-brain barrier and they differentiate into microglia. Neurons signal damage to neighbouring glia and recruit cells of hematopoietic origin specifically to the sites of damage. Finally, adult bone marrow stem cells may generate new neurons which are incorporated into the complex cytoarchitecture of the CNS. The results provide a new approach for the therapy of CNS disorders.
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Fontolan, Giorgia <1993&gt. "HISTORIC CORPORATE SOCIAL RESPONSIBILITY Gli effetti su brand image e performance nel caso Hugo Boss." Master's Degree Thesis, Università Ca' Foscari Venezia, 2019. http://hdl.handle.net/10579/14691.

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Negli ultimi anni si è sviluppato un acceso dibattito in merito a come un’azienda è in grado di affrontare le scelte prese dalle generazioni precedenti di manager; il passato di un’impresa in principio non veniva considerato come un elemento determinante nel processo decisionale che porta al conseguimento di determinati risultati. Si è evidenziato come questo tipo di decisioni si ripercuotono nel tempo sull’immagine e sulla performance aziendali, generando effetti sia negativi che positivi. La responsabilità in merito all’eredità storica di un’azienda prende il nome di Historic Corporate Responsibility. Il contesto narrativo, l’engagement che l’azienda ha sui propri clienti e il passato della stessa sono elementi che concorrono a determinare gli effetti che un caso di Historic Corporate Responsibility può avere all’interno della governance. Questa tesi vuole analizzare gli effetti della responsabilità storica delle aziende sia sull’immagine che sulle performance, prendendo in esame casi celebri a titolo esemplificativo per poi concentrarsi sull’analisi di un’azienda e sull’individuazione di tematiche legate alla CHR.
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Ordway, Gregory A., Attila Szebeni, Michelle J. Chandley, Craig A. Stockmeier, Lianbin Xiang, Samuel S. Newton, Gustavo Turecki, et al. "Low Gene Expression of Bone Morphogenetic Protein 7 in Brainstem Astrocytes in Major Depression." Digital Commons @ East Tennessee State University, 2012. https://dc.etsu.edu/etsu-works/8602.

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The noradrenergic locus coeruleus (LC) is the principal source of brain norepinephrine, a neurotransmitter thought to play a major role in the pathology of major depressive disorder (MDD) and in the therapeutic action of many antidepressant drugs. The goal of this study was to identify potential mediators of brain noradrenergic dysfunction in MDD. Bone morphogenetic protein 7 (BMP7), a member of the transforming growth factor-β superfamily, is a critical mediator of noradrenergic neuron differentiation during development and has neurotrophic and neuroprotective effects on mature catecholaminergic neurons. Real-time PCR of reversed transcribed RNA isolated from homogenates of LC tissue from 12 matched pairs of MDD subjects and psychiatrically normal control subjects revealed low levels of BMP7 gene expression in MDD. No differences in gene expression levels of other members of the BMP family were observed in the LC, and BMP7 gene expression was normal in the prefrontal cortex and amygdala in MDD subjects. Laser capture microdissection of noradrenergic neurons, astrocytes, and oligodendrocytes from the LC revealed that BMP7 gene expression was highest in LC astrocytes relative to the other cell types, and that the MDD-associated reduction in BMP7 gene expression was limited to astrocytes. Rats exposed to chronic social defeat exhibited a similar reduction in BMP7 gene expression in the LC. BMP7 has unique developmental and trophic actions on catecholamine neurons and these findings suggest that reduced astrocyte support for pontine LC neurons may contribute to pathology of brain noradrenergic neurons in MDD.
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Pohjolainen, V. (Virva). "Characterization of non-collagenous extracellular matrix proteins in cardiac and aortic valve remodelling." Doctoral thesis, Oulun yliopisto, 2012. http://urn.fi/urn:isbn:9789514299025.

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Abstract Heart failure (HF) and aortic valve stenosis (AS) are complex disorders affected by functional alterations and actively regulated remodelling of the heart and the aortic valve, respectively. In addition to structural proteins, such as collagens and elastin, the extracellular matrix (ECM) in the heart and the aortic valve comprises non-collagenous factors that are not strictly involved in the architecture but may modulate cardiac and valvular remodelling. In the present study the expression of non-collagenous fibrosis- and calcification-related ECM proteins was investigated in HF-associated cardiac remodelling from different origins as well as in fibrocalcific aortic valve disease leading to AS. The experimental models of pressure overload, myocardial infarction (MI) and chronic renal failure were used to study the cardiac expression of bone morphogenetic protein (BMP)-2, BMP-4, bone sialoprotein, matrix Gla protein (MGP), osteoactivin, osteopontin, periostin and/or pleiotrophin in vivo in cardiac remodelling. Human aortic valves, obtained from patients undergoing valve replacement, were studied to characterize the valvular expression of BMP-2, BMP-4, bone sialoprotein, MGP, osteoactivin, osteopontin, osteoprotegerin, periostin, pleiotrophin, and thrombospondins (TSPs) 1-4 in the different stages of fibrocalcific aortic valve disease. Left ventricular (LV) MGP expression was upregulated in vivo in non-uremic cardiac remodelling. In vitro results indicate that angiotensin II elevates MGP expression in cardiomyocytes and fibroblasts. Periostin gene expression was induced in cardiac but not in aortic valve remodelling and the cardiac induction in chronic renal insufficiency was associated with LV hypertrophy and blood pressure as well as the cardiac gene expression of other fibrosis-related genes. Bone sialoprotein and osteopontin were expressed in the aortic valves in parallel with calcification, and also in distinct models of cardiac remodelling. Osteoprotegerin protein expression in stenotic valves was weak regardless of a simultaneous increase in gene expression. BMPs were downregulated in AS and no change in LV gene expression was detected in uremic cardiac remodelling. All the studied TSPs were expressed in human aortic valves, and especially the expression of TSP-2 was shown to increase in fibrocalcific aortic valves simultaneously with decreased activation of the Akt/nuclear factor (NF)-κB-pathway. This study delineates distinct expression patterns of non-collagenous ECM proteins in pathological tissue remodelling in the heart and in the aortic valve, and thus emphasizes the role of ECM proteins as an important modulator of cardiac and aortic valve remodelling
Tiivistelmä Sydämen vajaatoiminnan ja aorttastenoosin taudinkuvaan kuuluvat toiminnallisten muutosten ohella aktiivisesti säädellyt soluväliaineen muutokset sydämen ja aorttaläpän rakenteessa. Soluväliaineen rakenteen muodostavien kollageenien ja elastiinin lisäksi soluväliaineessa on rakenteeseen kuulumattomia proteiineja. Tässä väitöskirjassa tutkittiin sidekudoksen kertymiseen ja kudosten kalkkiutumiseen osallistuvia soluväliaineen proteiineja sydämen vajaatoiminnassa sekä aorttastenoosiin johtavassa kalkkiuttavassa aorttaläppäviassa. Tutkimuksessa selvitettiin sydämen soluväliaineen proteiinien ilmentymistä painekuormituksen, sydäninfarktin ja pitkäaikaisen munuaisten vajaatoiminnan koemalleissa rotalla. Tutkittavia proteiineja olivat luun morfogeneettiset proteiinit 2 ja 4, luun sialoproteiini, matriksin Gla proteiini (MGP), osteoaktiviini, osteopontiini, periostiini ja pleiotropiini. Edellä mainittujen proteiinien lisäksi osteoprotegeriinin ja trombospondiinien 1-4 ilmentymistä tutkittiin kalkkiuttavan aorttaläppävian eri kehitysvaiheissa. Aorttaläpät oli kerätty tekoläppäleikkauspotilailta. Sydämessä MGP:n ilmentyminen lisääntyi kaikissa muissa paitsi munuaisten vajaatoiminnan koemallissa. Angiotensiini II nosti MGP:n ilmentymistä sydänlihassoluissa ja sidekudossoluissa. Periostiinin ilmentyminen lisääntyi sydämen uudelleenmuovautumisessa, muttei aorttaläppäviassa. Lisäksi munuaisten vajaatoiminnan aiheuttama periostiinin ilmentymisen muutos sydämessä liittyi sekä sydämen kasvuun, verenpaineen nousuun että muiden sidekudosta muokkaavien proteiinien ilmentymiseen. Luun sialoproteiinin ja osteopontiinin ilmentymiset erosivat toisistaan erilaisissa sydämen vajaatoiminnan malleissa, mutta aorttaläpissä niiden molempien ilmentyminen oli suhteessa läpän kalkkiutumiseen. Osteoprotegeriinin geenin ilmentyminen lisääntyi kalkkiutuneissa aorttaläpissä vaikkakin proteiinin määrä pysyi vähäisenä. Luun morfogeneettisten proteiinien ilmentyminen oli alentunut sairaissa läpissä, muttei sydämessä munuaisten vajaatoiminnan aikana. Aorttaläpissä ilmennettiin kaikkia trombospondiineita, joista trombospondiini-2:n ilmentyminen kasvoi sairaissa aorttaläpissä. Kalkkiutuneissa läpissä solunsisäinen Akt/NF-κB–signaalinvälitysjärjestelmä oli vaimentunut. Tutkimus osoittaa, että soluväliaineen proteiinien ilmentymistä säädellään eri tavoin sydämen vajaatoiminnassa ja aorttastenoosissa kudoksen uudelleenmuovautumisprosessin aikana
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Simonte, Giacoma 1984. "Endogenous mobilization of bone-marrow cells into murine retina induces fusion-mediated reprogramming of Müller glia cells." Doctoral thesis, Universitat Pompeu Fabra, 2016. http://hdl.handle.net/10803/543845.

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My PhD project was focused on understanding if endogenous bone-marrow cells (BMCs) could participate in the repair of mouse retina following N-Methyl-D-aspartate (NMDA) damage. We wanted to explore the possibility that endogenous BMCs could migrate from peripheral blood into the damaged retina and fuse with retinal neurons. We found that endogenous BMCs migrate into mouse retina upon NMDA damage and fuse with retinal neurons, mainly with Muller glia (MG) cells. MG cells undergo dedifferentiation and reprogramming after NMDA damage finally differentiating into ganglion and amacrine cells through a cell-fusion mediated mechanism. This neurogenic process was influenced by SDF-1/CXCR4 signaling pathway since when we manipulated it we were able to enhance or block the ability of MG cells to undergo reprogramming and to generate new neurons. All in all we described a novel mechanism by which murine MG cells can dedifferentiate through a cell fusion process with endogenous BMCs.
Mi proyecto de doctorado ha sido enfocado en entender si las células de la medula (BMCs) pueden participar en la reparación de la retina del ratón después de causar un daño con N-Methyl-D-aspartate (NMDA). Hemos querido explorar la posibilidad de que las BMCs pudiesen migrar desde la sangre periférica hasta la retina dañada y fusionarse con las neuronas retinianas. Hemos encontrado que las células endógenas de la médula son movilizadas hacia la retina del ratón después de causar el referido daño fusionándose con las neuronas de la retina, principalmente con las células gliales Müller (MG). Las células MG empiezan un proceso de desdiferenciación y reprogramación después de causar el daño de NMDA, y acaban diferenciándose en células ganglionares y amacrinas a través de un mecanismo de fusión celular. Este proceso neurogénico está influenciado también de la vía de señalación SDF-/CXCR4, cuando hemos manipulado esta vía de señalación celular hemos sido capaces de aumentar o bloquear la capacidad de las células MG de reprogramarse y de generar nuevas neuronas. En general hemos descrito un nuevo mecanismo mediante el cual las células MG pueden desdiferenciarse a través de un proceso de fusión celular con la células endógenas del la médula.
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Stoor, Patricia. "Interactions between oral and nasal microorganisms and the bioactive glass S53P4 with special reference to nasal cavity surgery." Turku : Turun Yliopisto, 2001. http://catalog.hathitrust.org/api/volumes/oclc/47834263.html.

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Fritsch, Andreas. "Multiscale explanation of elasticity and strength of bone and bone replacement materials made of hydroxyapatite, glass-ceramics, or titanium : a continuum micromechanics approach=mehrskalige erklärung der elastizit ät und festigkeit von knochen und knochenersatzmaterialien aus hydroxyapatit, glas-keramik oder titanium: ein kontinuumsmikromechanischer ansatz." Paris Est, 2009. http://pastel.archives-ouvertes.fr/docs/00/50/13/47/PDF/These_Fritsch_anglais.pdf.

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Knochen ist ein hierarchisch aufgebautes Material, gekennzeichnet durch eine erstaunliche Variabilität und Diversität. Knochenersatz- oder Biomaterialien sind wichtige Komponenten für künstliche Organe und werden auch als Gerüste für Tissue Engineering eingesetzt. Das Ziel dieser Dissertation ist die Vorhersage der Festigkeit von Knochen und Knochenersatzmaterialien auf Grund ihrer Zusammensetzung und Mikrostruktur mittels Mehrskalenmodellen. Die theoretischen Entwicklungen werden durch umfangreiche Experimente an kortikalen Knochen sowie an Biomaterialien aus Hydroxyapatit, Glas-Keramik und Titanium untermauert
Bone is a hierarchically organized material, characterized by an astonishing variability and diversity. Bone replacement or biomaterials are critical components in artificial organs, and they are also used as scaffolds in tissue engineering. The aim of this thesis is the prediction of the strength of bone and bone replacement materials, from their composition and microstructure, by means of multiscale models. The theoretical developments are supported by comprehensive experiments on cortical bone and on biomaterials made of hydroxyapatite, glass-ceramic, and titanium
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Janani, Ramesh. "B cell development and death in mouse bone marrow, effect of a bcl-2 transgene and lpr/gld mutations on in vivo dynamics and localisation of precursor B cells." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ36988.pdf.

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Jarov, Artem. "Régulation de l'adhérence des cellules neuroépithéliales : rôle de la protéine secrétée Sonic Hedgehog." Paris 6, 2002. http://www.theses.fr/2002PA066188.

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Books on the topic "Bose gla"

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Alojzije, Prosoli, ed. Sjeverozapadne Bosne glas: Akcija za Banjaluku. Zagreb: Bijeli put, 1995.

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Alojzije, Prosoli, ed. Sjeverozapadne Bosne glas: Akcija za Banjaluku. Zagreb: Bijeli put, 1995.

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Tancred, David Christopher. A new bone replacement material. Dublin: University College Dublin, 1996.

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Golchin, Beta. Boss Glam: The Ultimate Guide to Corporate Glam and Empowerment. Independently Published, 2020.

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Quick, Amanda. Gia tin kardia tou markisiou. Palindrom, 1994.

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Rock, Joanne. Ways to Tempt the Boss: Glam Office Romance Set in Brooklyn. Harlequin Enterprises ULC, 2021.

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Ways to Tempt the Boss: Glam office romance set in Brooklyn. Harlequin Desire, 2021.

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Book Your Boss Had Read: And Your Teammates Will Be Glad You Did. Independently Published, 2022.

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Nelson, Carisma. Glam Boss Lifestyle: Manifestation Journal for Writing Out All Visions and Goals , with Affirmations on Each Page. Independently Published, 2022.

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Girl Boss: The founder of Nasty Gal offers a sassy and irreverent manifesto for ambitious young women. United States: Seoman, 2015.

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Book chapters on the topic "Bose gla"

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Aucella, F., C. Guida, S. Modoni, M. D’Errico, and C. Stallone. "Bone GLA Protein in Chronic Renal Failure." In New Therapeutic Strategies in Nephrology, 154–56. Boston, MA: Springer US, 1991. http://dx.doi.org/10.1007/978-1-4615-3884-4_43.

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Charhon, Sam A., Pierre D. Delmas, Luc Malaval, Pascale M. Chavassieux, Marie Claire Chapuy, and Pierre J. Meunier. "Serum Bone Gla-Protein Compared to Bone Histomorphometry in Hemodialyzed Patients." In Phosphate and Mineral Homeostasis, 291–96. Boston, MA: Springer US, 1986. http://dx.doi.org/10.1007/978-1-4684-5206-8_37.

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Warneke, G., M. Barth, U. Hildebrand, P. Schmidt, H. V. Henning, R. Verwiebe, and F. Scheler. "Osteocalcin (Bone-GLA-Protein) als Marker für eine Aluminium-bedingte Mineralisationsstörung bei terminaler Niereninsuffizienz." In Aktuelle Aspekte der Osteologie, 161–64. Berlin, Heidelberg: Springer Berlin Heidelberg, 1992. http://dx.doi.org/10.1007/978-3-642-76766-1_28.

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Coen, Giorgio, Sandro Mazzaferro, Giuseppe Donato, Carlo Massimetti, Paola Ballanti, Franco Bondatti, Carlo Della Rocca, Antonella Smacchi, Flavia Mantazzoli, and Giulio A. Cinotti. "Effects of 1,25(OH)2D3 Administration on Serum Bone GLA Protein in Predialysis Chronic Renal Failure." In Phosphate and Mineral Homeostasis, 297–303. Boston, MA: Springer US, 1986. http://dx.doi.org/10.1007/978-1-4684-5206-8_38.

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"Bone-GLA-Protein." In Springer Reference Medizin, 476. Berlin, Heidelberg: Springer Berlin Heidelberg, 2019. http://dx.doi.org/10.1007/978-3-662-48986-4_300329.

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"Bone gla protein." In Springer Reference Medizin, 476. Berlin, Heidelberg: Springer Berlin Heidelberg, 2019. http://dx.doi.org/10.1007/978-3-662-48986-4_310688.

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Ayad, Shirley, Ray Boot-Handford, Martin J. Humphries, Karl E. Kadler, and Adrian Shuttleworth. "Osteocalcin γ-carboxyglutamic acid-containing protein, bone Gla-protein." In The Extracellular Matrix FactsBook, 231–32. Elsevier, 1998. http://dx.doi.org/10.1016/b978-012068911-8.50161-5.

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Lee, Eui-Seok, Puneet Wadhwa, Min-Keun Kim, Heng Bo Jiang, In-Woong Um, and Yu-Mi Kim. "Organic Matrix of Enamel and Dentin and Developmental Defects." In Human Teeth – Structure and Composition of Dental Hard Tissues and Developmental Dental Defects [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.99542.

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The anatomical crown of the tooth is covered by enamel and root is covered by cementum. The dentin forms the major part of the tooth. The dentin structure is very similar to that of the bone both physically and chemically which is why many scientists have wondered about using its properties for developing a novel bone graft material. In contrast with hard and brittle enamel dentin is viscoelastic. The organic structure of dentin which is about 35% is composed of mainly type I collagen embedded in mucopolysaccharides ground substance. Approximately half of the non-collagenous composition consists of hyperphosphorylated proteins. The acidic glycoproteins, Gla-proteins, serum proteins, proteoglycans etc. composes the remaining part. The dentin matrix consists of many similar proteins as that of bone like dentin phosphoprotein, dentin sialoprotein etc.. The matrix also consists of many growth factors. Any external disturbance like an infection, trauma, calcium or phosphorous metabolic changes can lead to defective amelogenesis. Mutational changes can lead to defect in dentin. An early diagnosis can result in a satisfactory treatment plan contributing to functional and esthetical compensation.
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Price, Paul A. "Vitamin K-Dependent Formation of Bone Gla Protein (Osteocalcin) and Its Function." In Vitamins & Hormones, 65–108. Elsevier, 1985. http://dx.doi.org/10.1016/s0083-6729(08)60061-8.

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Correa Rossi, Mariana, Liliana Romero Resendiz, and Vicente Amigó Borrás. "Magnesium in Synthesis of Porous and Biofunctionalized Metallic Materials." In Magnesium Chemistry - Current Trends and Future Perspectives [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.102083.

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Magnesium particles are used in metallurgic routes, where it can be total or partially evaporated creating pores for ingrowth bone tissue. This book chapter contains the latest findings on the microstructural physical and mechanical properties of β-Ti alloys with Mg additions designed and obtained by the authors. As well as the main new techniques used to fabricate Ti-Mg alloys. An especial emphasis on the microstructure-properties relationship was made to assist on the guide for future efforts of the scientific community towards developing more efficient biomaterials. The β % were related to the low elastic modulus which were in the range of 31–49 GPa close to cortical bone and hardness close to commercial Ti grade 2. The compressive strength was greater than the value of cortical bone. Pore size were in the range of 5–100 μm depending on the sintering temperature, with higher wettability the samples with more porosity. These findings were promising to application of β titanium alloys containing Mg for orthopedic application.
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Conference papers on the topic "Bose gla"

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Singh, Dilpreet, Pulak Mohan Pandey, and Dinesh Kalyanasundaram. "Mechanical Properties of the Human Elbow Bones Measured by Nanoindentation and Microindentation." In ASME 2018 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2018. http://dx.doi.org/10.1115/imece2018-87406.

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In this article, the nano and microhardness and the elastic modulus of the human elbow bones (humerus, ulna and radius) were studied. The nano properties were studied using load controlled technique with a load of 20 mN, while the micro properties were studied under 1 N load. A total of nine bone samples from three cadavers of ages between 45 and 55 years were tested. The measurements were carried out on both osteonal and interstitial bone in the longitudinal direction. The nanoindentation results indicated higher values for interstitial bone (hardness: 0.74 ± 0.09 GPa, elastic modulus: 19.05 ± 1.92 GPa) than for osteonal bone (hardness: 0.53 ± 0.05 GPa, elastic modulus: 16.66 ± 1.55 GPa). Consistent results were obtained at a depth of penetration between 1.1 μm to 1.5 μm in nanoindentation. In the case of microindentation, the microhardness and elastic modulus of interstitial bone was found to be 0.65 ± 0.07 GPa and 20.60 ± 2.27 GPa. Whereas for osteonal bone it was observed to be 0.60 ± 0.08 GPa and 14.56 ± 1.42 GPa respectively. The depth of penetration varies between the 8 μm to 11 μm for microindentation studies. In both measurement scales, a noticeable difference was observed between the osteonal and interstitial bone properties. As bone is a hierarchical structure, identifying the mechanical properties at the lamellar level helps in understanding the local mechanical environment of basic elements of the bones and predicting the behavior of the bone due to physiological loading.
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Papić, Žarko. "Kratka istorija konstitutivnosti u BiH." In Naučno-stručni simpozij: Reforma izbornog zakonodavstva Bosne i Hercegovine. Academy of Sciences and Arts of Bosnia and Herzegovina, 2021. http://dx.doi.org/10.5644/pi2021.198.12.

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Ravnopravnost Bošnjaka, Hrvata i Srba i građana osnova je Bosne i Hercegovine, njihove zajedničke nedjeljive domovine. Nacionalna ravnopravnost je ostvarivanje kolektivnih ljudskih prava. Konstitutivnost je ustavni mehanizam kojim se ona ostvaruje. Nužan je dogovor, nema većine i manjine niti preglasavanja. Ustavni mehanizmi kojim se obezbjeđuje konstitutivnost moraju se modifikovati. Time će e spriječiti blokada institucija. Ukidanje konstitutivnosti i tzv. građanskog principa „jedan čovjek jedan glas“ destabilizuje zemlju
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Khandaker, Morshed, Yanling Li, Ping Liu, and Melville B. Vaughan. "Bioactive Additives and Functional Monomers Affect on PMMA Bone Cement: Mechanical and Biocompatibility Properties." In ASME 2011 International Mechanical Engineering Congress and Exposition. ASMEDC, 2011. http://dx.doi.org/10.1115/imece2011-64369.

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The most common bone cement material used clinically today for orthopedic surgeries is poly methyl methacrylate (PMMA). In general, poly Methyl MethAcrylate (PMMA) beads are added to MMA monomer with bead and monomer ratio of 2:1 to prepare the PMMA bone cement. Conventional PMMA bone cement has several mechanical and biological disadvantages. To overcome these disadvantages, researchers investigated several bioactive additives to PMMA bone cement, such as MgO, hydroxyapatite (HAp), chitosan (CS). Additionally, functional monomer, such as glycidyl methacrylate (GMA) was used in addition or substitution to MMA to enhance the properties of PMMA bone cement. A comparative study is required to evaluate the effect that different bioadditives and monomers have on the mechanical and biological performances on PMMA bone cement. The goal of this study is to determine the most suitable additives and alternative monomer for PMMA bone cement that can enhance the mechanical and biological performances of PMMA bone cement. Cobalt™ HV bone cement (referred as CBC), a commercial orthopedic bone cement, was used in this study as PMMA bone cement. MgO, hydroxyapatite (HAp), chitin (CT), chitosan (CS), Barium sulfate (BaSO4) and Silica (SiO2) were mixed with PMMA beads to prepare CBC-MgO, CBC-HAp, CBC-CT, CBC-CS, CBC-BaSO4 and CBC-SiO2 specimens. Additives included CBC were referred as composite specimen. CBC and composite specimens were further grouped according to the application of GMA as replacement of MMA monomer. Two groups of CBC and composite specimen were prepared. In the first group, CBC and composite specimens were prepared using MMA monomer only, referred as without GMA specimen. In the second group, CBC and composite specimens were prepared using GMA and MMA monomers, referred as with GMA specimen. There are three general research questions: (1) Is there a significant difference in the mechanical and biological performances between CBC (control) and different composite specimens that contain GMA? (2) Is there a significant difference in the in the mechanical and biological performances between CBC (control) and different composite specimens that do not contain GMA? and (3) Is there a significant difference in the mechanical and biological performances between specimens mixed with and without GMA? Elastic and fracture properties of different CBC and composite cements were calculated from three point bend experiments. Osteoblast cell adhesion experiments were performed on different CBC and composite cement on a custom made well plate. This study found that flexural strength and fracture toughness of the CBC specimens that contain GMA is significantly greater than the flexural strengths of all other specimens that contain GMA. In contrast, flexural strength and fracture toughness of the CBC-SiO2 specimens that do not contain GMA is significantly greater than the flexural strengths of all other specimens that contain GMA. This study also found that cell adhesion on the MgO impregnated CBC specimens is significantly greater than the cell adhesion of all other specimens for samples that contain GMA or do not contain GMA.
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Melander, Jennifer R., Rachel A. Weiler, Bradley D. Miller, Kathleen V. Kilway, and J. David Eick. "Flexural Properties of Silorane Bone Cement." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53922.

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There has been little change in the formulation of bone cements since Sir John Charnley first developed them in the 1970s. Bone cements are methacrylate based systems packaged in two components [1]. The powder component contains a mixture of polymethyl methacrylate (PMMA), methyl methacrylate-styrene-copolymer, and a radio opacifier (either barium sulfate or zirconium oxide) [2]. The second component is a liquid monomer typically containing methyl methacrylate, N, N-dimethyl-p-toluidine (activator), and hydroquinone. Flexural strength and flexural modulus of bone cements range between 60–75 MPa and 2.2–3.3 GPa, respectively [3, 4]. ISO 5833 requires bone cements to have a strength greater than 50 MPa and a modulus greater than 1.8 GPa [5].
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Hage, Ilige S., Charbel Y. Seif, and Ramsey F. Hamade. "Measuring Compressive Modulus of Elasticity Across Cortical Bone Thickness of Mid-Diaphysis Bovine Femur." In ASME 2016 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2016. http://dx.doi.org/10.1115/imece2016-66383.

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The aim of this study is to quantitatively discern the compressive stiffness along the thickness of bovine cortical bone from the inner surface toward the bone’s periosteum (outer) surface. Ring-shaped bone slices from randomly selected 3 cow bovine bones were cut from mid diaphysis femur. Micro hardness measurements (ASTM E384-11e1 Standard- test method for Vickers hardness of materials with load of 500gf and dwelling time of 10s) were conducted along radial lines emanating from the geometric center of the bone transverse cross section. Values of compressive stiffness (longitudinal young’s modulus, E11) using the slope of the unloading curve of micro hardness tests at maximum load were extracted per the method advanced by Oliver and Pharr. Fitting these data points in a linear fit resulted in statistically significant and simple linear equations for compressive modulus as function of radial distance. For the anatomical anterior and posterior regions, compressive modulus values were found to range from 18 to 23.4 GPa (average of 21.2 GPa) and 23 to 26.0 GPa (average of 23.8 GPa), respectively. This is about 12% increase in average stiffness values of outer lamella near the periosteum as compared with inner regions.
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Shayesteh Moghaddam, Narges, Amirhesam Amerinatanzi, Soheil Saedi, Ali Sadi Turabi, Haluk Karaca, and Mohammad Elahinia. "Stiffness Tuning of NiTi Implants Through Aging." In ASME 2016 Conference on Smart Materials, Adaptive Structures and Intelligent Systems. American Society of Mechanical Engineers, 2016. http://dx.doi.org/10.1115/smasis2016-9289.

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NiTi alloys are interesting materials for biomedical implants since they offer unique characteristics such as superelastic behavior, low stiffness (I.e., modulus of elasticity) close to that of the cortical bone, and shock absorption. Thermal treatments are the most common and practical ways to improve the superelasticity of these alloys. In addition to the superelastic behavior of the metallic implants, it is important for the implants to have a stiffness similar to that of cortical bone in order to reduce the risk of failure caused by stress shielding. The cortical bone has a stiffness ranging from 12 to 31 GPa for different patients (e.g., sex, age, mechanical behavior of bone) and various bone locations (e.g., jaw implant, hip implant), while the untreated Ni-rich NiTi has the stiffness equal to 41.37 GPa. One recently used technique to lower the stiffness of NiTi implant is to introduce porosity into the implant. The major problem associated with the imposed porosity is stress concentration on the pore walls and the subsequent implant failure. In this work, the purpose is to tune the stiffness via changing the post-heat treatment conditions, i.e., aging time and aging temperature. In this study, several bulk specimens of Ni-rich NiTi (SLM Ni50.8Ti49.2) were additively manufactured using selective laser melting (SLM) technique. The samples were solution annealed (950 °C, 5.5 h) and subsequently water quenched to provide equilibrium state in the samples. Subsequently, different aging conditions (350 °C and 450 °C for 5 to 18 hours) were applied to the samples. Mechanical testing (compression) was conducted on the samples and the stiffness of each sample was defined to investigate the effect of aging on the stiffness. Our results indicate that the range of 29.9 to 43.7 GPa for stiffness can be achieved through the implant via different time period and temperatures for aging. The modulus of 43.7 GPa is attributed to 10 hours heat treatment under 450 °C and the modulus of 29.9 GPa is attributed to 18 hours heat treatment under 350 °C.
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Moghaddam, Narges Shayesteh, Mohammad Elahinia, Michael Miller, and David Dean. "Enhancement of Bone Implants by Substituting Nitinol for Titanium (Ti-6Al-4V): A Modeling Comparison." In ASME 2014 Conference on Smart Materials, Adaptive Structures and Intelligent Systems. American Society of Mechanical Engineers, 2014. http://dx.doi.org/10.1115/smasis2014-7648.

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Mandibular segmental defect reconstruction is most often necessitated by tumor resection, trauma, infection, or osteoradionecrosis. The standard of care treatment for mandibular segmental defect repair involves using metallic plates to immobilize fibula grafts, which replace the resected portion of mandible. Surgical grade 5 titanium (Ti-6Al-4V) is commonly used to fabricate the fixture plate due to its low density, high strength, and high biocompatibility. One of the potential problems with mandibular reconstruction is stress shielding caused by a stiffness mismatch between the Titanium fixation plate and the remaining mandible bone and the bone grafts. A highly stiff fixture carries a large portion of the load (e.g., muscle loading and bite force), therefore the surrounding mandible would undergo reduced stress. As a result the area receiving less strain would remodel and may undergo significant resorption. This process may continue until the implant fails. To avoid stress shielding it is ideal to use fixtures with stiffness similar to that of the surrounding bone. Although Ti-6Al-4V has a lower stiffness (110 GPa) than other common materials (e.g., stainless steel, tantalum), it is still much stiffer than the cancellous (1.5–4.5 GPa) and cortical portions of the mandible (17.6–31.2 GPa). As a solution, we offer a nitinol in order to reduce stiffness of the fixation hardware to the level of mandible. To this end, we performed a finite element analysis to look at strain distribution in a human mandible in three different cases: I) healthy mandible, II) resected mandible treated with a Ti-6Al-4V bone plate, III) resected mandible treated with a nitinol bone plate. In order to predict the implant’s success, it is useful to simulate the stress-strain trajectories through the treated mandible. This work covers a modeling approach to confirm superiority of nitinol for mandibular reconstruction. Our results show that the stress-strain trajectories of the mandibular reconstruction using nitinol fixation is closer to normal than if grade 5 surgical titanium fixation is used.
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Amerinatanzi, Amirhesam, Narges Shayesteh Moghaddam, Hamdy Ibrahim, and Mohammad Elahinia. "Evaluating a NiTi Implant Under Realistic Loads: A Simulation Study." In ASME 2016 Conference on Smart Materials, Adaptive Structures and Intelligent Systems. American Society of Mechanical Engineers, 2016. http://dx.doi.org/10.1115/smasis2016-9287.

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Additive manufacturing (i.e. 3D printing) has only recently be shown as a well-established technology to create complex shapes and porous structures from different biocompatible metal powder such as titanium, nitinol, and stainless steel alloys. This allows for manufacturing bone fixation hardware with patient-specific geometry and properties (e.g. density and mechanical properties) directly from CAD files. Superelastic NiTi is one of the most biocompatible alloys with high shock absorption and biomimetic hysteresis behavior. More importantly, NiTi has the lowest stiffness (36–68 GPa) among all biocompatible alloys [1]. The stiffness of NiTi can further be reduced, to the level of the cortical bone (10–31.2 GPa), by introducing engineered porosity using additive manufacturing [2–4]. The low level of fixation stiffness allows for bone to receive a stress profile close to that of healthy bone during the healing period. This enhances the bone remodeling process (Wolf’s Law) which primarily driven by the pattern of stress. Also, this match in the stiffness of bone and fixation mitigates the problem of stress shielding and detrimental stress concentrations. Stress shielding is a known problem for the currently in-use Ti-6Al-4V fixation hardware. The high stiffness of Ti-6Al-4V (112 GPa) compared to bone results in the absence of mechanical loading on the adjacent bone that causes loss of bone mass and density and subsequently bone/implant failure. We have proposed additively manufactured porous NiTi fixation hardware with a patient-specific stiffness to be used for the mandibular reconstructive surgery (MRS). In MRS, the use of metallic fixation hardware and double barrel fibula graft is the standard methodology to restore the mandible functionality and aesthetic. A validated finite element model was developed from a dried cadaveric mandible using CT scan data. The model simulated a patient’s mandible after mandibular reconstructive surgery to compare the performance of the conventional Ti-6Al-4V fixation hardware with the proposed one (porous superelastic NiTi fixation plates). An optimized level of porosity was determined to match the NiTi equivalent stiffness to that of a resected bone, then it was imposed to the simulated fixation plates. Moreover, the material property of superelastic NiTi was simulated by using a validated customized code. The code was calibrated by using DSC analysis and mechanical tests on several prepared bulk samples of Ni-rich NiTi. The model was run under common activities such as chewing by considering different levels of the applied fastening torques on screws. The results show a higher level of stress distribution on mandible cortical bone in the case of using NiTi fixation plates. Based on wolf’s law it can lead to a lower level of stress shielding on the grafted bone and over time bone can remodel itself. Moreover, the results suggest an optimum fastening torque for fastening the screws for the superelastic fixations causes more normal distribution of stress on the bone similar to that for the healthy mandible. Finally, we successfully fabricated the stiffness-matched porous NiTi fixation plates using selective laser melting technique, and they were mounted on the dried cadaveric mandible used to create the finite element model.
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Ferguson, Christina L., Laura J. Crossey, Karl Karlstrom, and Jordan C. Anderson. "GEOCHEMICAL CHARACTERIZATION OF BOUSE CARBONATES: TOWARD AN UNDERSTANDING OF DIAGENESIS OF BOUSE CARBONATES." In Joint 70th Annual Rocky Mountain GSA Section / 114th Annual Cordilleran GSA Section Meeting - 2018. Geological Society of America, 2018. http://dx.doi.org/10.1130/abs/2018rm-313964.

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Guan, Yabo, Harlan Bruner, Narayan Yoganandan, Frank A. Pintar, and Dennis J. Maiman. "Block-Fixation Finite Element Lumbar Spine Model to Examine Load-Sharing, Bone-Screw Interaction, and Stress in Carbon Fiber Reinforced PEEK Construct." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-206654.

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Carbon-fiber-reinforced (CFR) polyetheretherketone (PEEK) combines the high strength of metals with the extensive biocompatibility and imaging compatibility of polymers. CFR PEEK composite is similar to the stiffness of cortical bone (approximately 15–20 GPa) and shows comparable performance to metallic materials such as titanium alloy, cobalt chrome alloy, and stainless steel in terms of strength. CFR-PEEK becomes an attractive alternative to the metallic materials traditionally used in spinal implants (e.g. pedicle screw rod fixation). Finite element (FE) models have been developed to study the biomechanical behaviors of spinal structures with pedicle screw rod fixation ([1–5]). However, it is limited to implement these models to study the bone screw interaction, and local bone strain at the bone screw interface due to the intrinsic low mesh density of the intact model. The aim of this study is to develop a refined block fixation FE model to investigate the load sharing, bone screw interaction, and strain/stress in CFR PEEK construct.
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