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Journal articles on the topic 'Boston Regulations'

Author: Grafiati

Published: 26 July 2024

Last updated: 31 July 2025

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1

Shalev, Moshe. "Boston proposes stringent regulations of biological laboratories." Lab Animal 35, no. 1 (2006): 14. http://dx.doi.org/10.1038/laban0106-14.

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Thalheimer, Erich. "Developing a Comprehensive Construction Noise Specification." INTER-NOISE and NOISE-CON Congress and Conference Proceedings 266, no. 2 (2023): 10–17. http://dx.doi.org/10.3397/nc_2023_0003.

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As acoustical engineers, we are often asked to develop community noise-related guidelines, regulations, laws, ordinances, and project specifications. This paper will describe the ingredients needed to develop a robust and defensible construction noise specification that is both enforceable and effective. It will be based on the author's past and current experiences developing such specifications, including those used for the Big Dig project in Boston, FHWA's construction noise handbook, the New York City construction noise regulation, as well as dozens of large-scale construction projects acro

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Paté-Cornell, M. Elisabeth. "Costs and Benefits of Seismic Upgrading of Some Buildings in the Boston Area." Earthquake Spectra 1, no. 4 (1985): 721–40. http://dx.doi.org/10.1193/1.1585290.

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We examine here the costs and benefits of reinforcing some existing buildings in Boston at the time of remodelling with significant change of use. The buildings of interest are the unreinforced masonry warehouses and the reinforced concrete manufacturing buildings that are remodelled into apartment or office buildings. Given some estimates of the Boston seismicity and of the performance of these buildings in earthquakes with and without additional reinforcement, we evaluate three possible levels of reinforcement that the Masssachusetts Seismic Advisory Committee could recommend as part of the

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Weinstein, Asha. "Curing Congestion: Competing Plans for a Loop Highway and Parking Regulations in Boston in the 1920s." Journal of Planning History 3, no. 4 (2004): 292–311. http://dx.doi.org/10.1177/1538513204269598.

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Aryani, Rosalia Nita, Ni Made Rustini, and Taman Sari. "Analisis Posisi Bersaing dan Strategi Bauran Pemasaran untuk Meningkatkan Jumlah Kunjungan Pada Handara Golf and Resort di Bedugul Bali." WACANA EKONOMI (Jurnal Ekonomi, Bisnis dan Akuntansi) 19, no. 2 (2020): 91–97. http://dx.doi.org/10.22225/we.19.2.2318.91-97.

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 This research to determine the competitive position based on the Boston Consulting Group matrix, to find out internal variables including strengths and weaknesses as well as external variables including opportunities and threats and to find out relevant marketing mix strategies to increase the number of visits. The study was conducted at Handara Golf and Resort in Bedugul Bali. Data analysis techniques used are the Boston Consulting Group matrix analysis and SWOT analysis. The analysis shows that using BCG matrix analysis, the company is in the position of dogs with a growth rate of 7.0

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Su, Haiyan, and Linlin Chen. "Empirical-Likelihood-Based Inference for Partially Linear Models." Mathematics 12, no. 1 (2024): 162. http://dx.doi.org/10.3390/math12010162.

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Partially linear models find extensive application in biometrics, econometrics, social sciences, and various other fields due to their versatility in accommodating both parametric and nonparametric elements. This study aims to establish statistical inference for the parametric component effects within these models, employing a nonparametric empirical likelihood approach. The proposed method involves a projection step to eliminate the nuisance nonparametric component and utilizes an empirical-likelihood-based technique, along with the Bartlett correction, to enhance the coverage probability of

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Williams, Joyce, and David Williams. "How the Deadliest Nightclub Fire in History Improved Medical Interventions and Regulations and Impacted Legal Enforcement." Prehospital and Disaster Medicine 38, S1 (2023): s82. http://dx.doi.org/10.1017/s1049023x23002352.

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Introduction:This presentation is a continuation of a WADEM presentation from 2013 entitled: Fires in Social Settings: An Examination of Prevention Strategies.Method:Nightclubs should be a place of fun and frivolity, but sometimes they become a place of death and destruction. The fire at the Cocoanut Grove in Boston Massachusetts, USA, in November, 1942 was the deadliest nightclub fire worldwide with a death toll of 492 and over 130 injured. Since that tragedy, regulations that could prevent or mitigate lethal incidents at nightclubs continue to be unenforced globally. This presentation will d

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Li, Wenjun, Tami Gouveia, Cheryl Sbarra, et al. "Has Boston's 2011 cigar packaging and pricing regulation reduced availability of single-flavoured cigars popular with youth?" Tobacco Control 26, no. 2 (2016): 135–40. http://dx.doi.org/10.1136/tobaccocontrol-2015-052619.

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ObjectiveWe evaluated retailer compliance with a cigar packaging and pricing regulation in Boston, Massachusetts, enacted in February 2012, and the regulation's impact on availability of single cigars.MethodsGrape-flavoured Dutch Masters (DM) single-packaged cigars were examined as market indicator. At quarterly intervals from October 2011 to December 2014, availability and price of DM single cigars were observed through professional inspector visits to tobacco retailers in Boston (n=2232) and 10 comparison cities (n=3400). Differences in price and availability were examined between Boston and

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Wissman-Weber, Nichole K., and David L. Levy. "Climate adaptation in the Anthropocene: Constructing and contesting urban risk regimes." Organization 25, no. 4 (2018): 491–516. http://dx.doi.org/10.1177/1350508418775812.

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The Anthropocene heralds a new era of heightened and unknown risks, particularly regarding the impacts of climate change. This article explores the initial phase of organizing for climate adaptation in Boston, Massachusetts, examining how multiple actors, including business, government, and community organization, are interacting as they attempt to comprehend, assess, and act on this issue. To understand this process of organizing, we develop the concept of ‘risk regime’ as a contingently stabilized system with governance, economic, and discursive dimensions. We draw from theories of risk, org

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Lewandrowski, Kent, Kimberly Gregory, and Donna Macmillan. "Assuring Quality in Point-of-Care Testing: Evolution of Technologies, Informatics, and Program Management." Archives of Pathology & Laboratory Medicine 135, no. 11 (2011): 1405–14. http://dx.doi.org/10.5858/arpa.2011-0157-ra.

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Context.—Managing the quality of point-of-care testing (POCT) is a continuing challenge. Advances in testing technologies and the development of specialized informatics for POCT have greatly improved the ability of hospitals to manage their POCT program. Objectives.—To present the evolving role of technology improvement, informatics, and program management as the key developments to ensure the quality of POCT. Data Sources.—This presentation is based on a review of the literature and on our experiences with POCT at the Massachusetts General Hospital (Boston). Conclusions.—Federal and state reg

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Schumacher, Melissa, Pamela Durán-Díaz, Anne Kristiina Kurjenoja, Eduardo Gutiérrez-Juárez, and David A. González-Rivas. "Evolution and Collapse of Ejidos in Mexico—To What Extent Is Communal Land Used for Urban Development?" Land 8, no. 10 (2019): 146. http://dx.doi.org/10.3390/land8100146.

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The ejido system, based on communal land in Mexico, was transformed to private ownership due to neoliberal trends in the 1990s. Based on the theory of stakeholders being agents of change, this study aimed to describe the land policies that changed the ejido system into private development to show how land tenure change is shaping urban growth. To demonstrate this, municipalities of San Andrés Cholula and Santa Clara Ocoyucan were selected as case studies. Within this context, we evaluated how much ejido land is being urbanized due to real estate market forces and what type of urbanization mode

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Gallagher, Elizabeth, Kathrin Boerner, Yijung Kim, Kyungmin Kim, and Daniela Jopp. "Challenges for Children 65+ Caring for Parents 90+ With Dementia During COVID-19." Innovation in Aging 5, Supplement_1 (2021): 139. http://dx.doi.org/10.1093/geroni/igab046.536.

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Abstract With the rise of the novel coronavirus, family caregivers of persons with dementia have been tasked with adapting to an entirely new caregiving landscape. Adult children caring for parents in the ‘oldest old’ age group bear an additional burden. Namely, children that are older adults themselves are navigating the joint vulnerability of both their own and their parents’ aging-related issues (e.g., health problems). The aim of this study was to explore the experiences of dementia caregivers during COVID-19 from the unique perspective of children aged 65 and older caring for parents aged

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Paul, Edward, Danya Fortess Fullerton, Ellen Cohen, Ellen Lawton, Anne Ryan, and Megan Sandel. "Medical-Legal Partnerships: Addressing Competency Needs Through Lawyers." Journal of Graduate Medical Education 1, no. 2 (2009): 304–9. http://dx.doi.org/10.4300/jgme-d-09-00016.1.

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Abstract Background Many low- and moderate-income individuals and families have at least one unmet legal need (for example, unsafe housing conditions, lack of access to food and/or income support, lack of access to health care), which, if left unaddressed, can have harmful consequences on health. Eighty unique medical-legal partnership programs, serving over 180 clinics and hospitals nationwide, seek to combine the strengths of medical and legal professionals to address patients' legal needs before they become crises. Each partnership is adapted to serve the specific needs of its own patient b

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Rusuli, Yusufujiang, Lanhai Li, Fadong Li, and Mamattursun Eziz. "Water-level regulation for freshwater management of Bosten Lake in Xinjiang, China." Water Supply 16, no. 3 (2016): 828–36. http://dx.doi.org/10.2166/ws.2016.002.

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The Bosten Lake is the largest inland freshwater lake of China, in which water level and salinity fluctuate due to the imbalance between inflows and outflows under climate change and anthropogenic activities. This paper employed system dynamics as an effective methodology to grasp the regulation rules for sustainable freshwater management of the Bosten Lake. Results show the following. (1) Changing of lake water salinity is not only affected by the salinity of water entering and leaving, but is mostly a result of water exchange rate (WER) and the lake level fluctuation. (2) According to the es

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Mindarti, Lely Indah, Akmal Malik, Bambang Supriyono, and Hermawan. "Quality of Regional Election Implementation as Determinant of Performance of Simultaneous Regional Election: Community Trust and Satisfaction as Mediation, and Regulatory Harmonization as Moderation." Review of Pacific Basin Financial Markets and Policies 24, no. 01 (2021): 2150008. http://dx.doi.org/10.1142/s0219091521500089.

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The objectives of this research are to analyze how to build the political and managerial balance of government in direct and simultaneous regional elections in Indonesia based on the managerial approach of government and the decentralization approach quantitatively. Data analysis uses the Social Network Analysis (SNA) or Social Network Theory (SNT) approach to map policies using the XL Node and first-order confirmatory factor analysis which is a form of measurement model in the Structural Equation Model (SEM). The population in this study is the Regency/City and Province Organizers of the 2018

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Firman, Firman. "MERITOKRASI DAN NETRALITAS APARATUR SIPIL NEGARA (ASN) DALAM PENGARUH PILKADA LANGSUNG." Indonesian Journal of Public Administration (IJPA) 3, no. 2 (2017): 88–105. http://dx.doi.org/10.52447/ijpa.v3i2.1136.

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Abstract: This study is about the meritocracy system of bureaucracy and the neutrality of civil state apparatus (ASN) in the face of elections to the elections. In various regions there is always a problem of bureaucratic professionalism issues. Despite the various regulations to regulate ASN to be neutral and independent so that the democratic process in this case direct election of the head of the region can run well. However, this issue is always repeated with different schemes for the lust of power and bureaucrat positions that can be facilitated or lifted / accelerated to occupy positions

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Iwadate, Dosuke, Keisuke Yamamoto, Hiroyuki Kato, Keisuke Tateishi, and Mitsuhiro Fujishiro. "Abstract A084: CDK12 inhibition drives mitotic catastrophe, triggering genome instability and innate immune response in pancreatic cancer." Cancer Research 84, no. 17_Supplement_2 (2024): A084. http://dx.doi.org/10.1158/1538-7445.pancreatic24-a084.

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Abstract Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with limited therapies. In our screening using patient-derived organoids, we identified cyclin-dependent kinase 12 (CDK12) as a promising target in a subset of PDAC. Both pharmacological and genetic inhibition of CDK12 exerted potent antitumor activity in vitro and in vivo, inducing double-strand DNA breaks and apoptosis. CDK12 is a member of cyclin-dependent kinases that is involved in gene expression regulations at multiple levels. Recently, CDK12 has gained attention as a therapeutic target in several types of cancers incl

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Downs, Charles A., and My N. Helms. "Regulation of ion transport by oxidants." American Journal of Physiology-Lung Cellular and Molecular Physiology 305, no. 9 (2013): L595—L603. http://dx.doi.org/10.1152/ajplung.00212.2013.

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Ion channels perform a variety of cellular functions in lung epithelia. Oxidant- and antioxidant-mediated mechanisms (that is, redox regulation) of ion channels are areas of intense research. Significant progress has been made in our understanding of redox regulation of ion channels since the last Experimental Biology report in 2003. Advancements include: 1) identification of nonphagocytic NADPH oxidases as sources of regulated reactive species (RS) production in epithelia, 2) an understanding that excessive treatment with antioxidants can result in greater oxidative stress, and 3) characteriz

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Ahuja, Rakesh, Akash Desai, Jung Hyun Yun, Eric Soltycki, Vinit Khanna, and Balasubramani Natarajan. "Road to becoming Y-90 authorized user as an integrated vascular and interventional radiology resident (NRC alternate pathway)." American Journal of Interventional Radiology 5 (July 9, 2021): 11. http://dx.doi.org/10.25259/ajir_19_2021.

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Yttrium-90 (Y-90) radioembolization, also called transarterial radioembolization (TARE), is a catheter-directed therapy for direct delivery of internal radiation to tumors in the form of microspheres. It is currently available in two forms, either as a constituent of glass microspheres called TheraSphere® (BTG Ltd., London, UK [now Boston Scientific, Marlborough, MA, USA]) or as a biocompatible resin-based microsphere called SIR-Spheres® (Sirtex Medical Ltd., Woburn, MA, USA). Once these microspheres are delivered to the tumor through an arterial pathway, they are embedded within the tumor mic

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Sung, Yu, Daniel J. Cantliffe, and Russell T. Nagata. "Seed Developmental Temperature Regulation of Thermotolerance in Lettuce." Journal of the American Society for Horticultural Science 123, no. 4 (1998): 700–705. http://dx.doi.org/10.21273/jashs.123.4.700.

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Lettuce (Lactuca sativa L.) seeds can fail to germinate at temperatures above 24 °C. The degree of thermotolerance is thought to be at least partly related to the environment under which the seed developed. In order to study the effects of temperature during seed development on subsequent germination, various lettuce genotypes were screened for their ability to germinate at temperatures ranging from 20 to 38 °C. Seeds of the selected genotypes `Dark Green Boston' and `Valmaine' (thermosensitive), `Floricos 83', `Everglades', and PI 251245 (thermotolerant) were produced at 20/10, 25/15, 30/20,

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Hajdarpašić, Lejla. "Coverage and Values of Legal Deposit in Bosnia and Herzegovina (1945–1995)." BOSNIACA, no. 29 (December 24, 2024): 13–46. https://doi.org/10.37083/bosn.2024.29.13.

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Goal: Legal deposit is a complex system of multiple benefits, and by mapping adapted legal deposit regulations from 1945 to 1995 in Yugoslavia and Bosnia and Herzegovina, the aim of this research is to look at the development of the legal deposit in the context of redefining its coverage and the legislatively defined goals of the legal deposit. Approach/methodology/design: By researching the previous literature and reviewing official publications, that is examining the titles and full texts of published regulations in the printed editions of official publications, the relevant regulations rela

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Zenkina, Elena V. "STRATEGIES AND METHODS FOR DIGITAL BUSINESS TRANSFORMATION AND THEIR USE IN COMPANY MANAGEMENT PROCESSES." Science and art of management / Bulletin of the Institute of Economics, Management and Law of the Russian State University for the Humanities, no. 1 (2023): 10–25. http://dx.doi.org/10.28995/2782-2222-2023-1-10-25.

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The article reflects strategies and methods that ensure the efficiency and performance of managing existing business processes in small and mediumsized enterprises through the use of digital technologies and digitized data. It analyzes in detail the UK’s experience in developing digital transformation policies for small and medium-sized businesses. The relevance of the study is due to the fact that in the 21st century it is a strong economic system that determines the stability and well-being of modern states. Today it is impossible to imagine a market economy without small and medium-sized bu

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Glaeser, Edward L., and Bryce A. Ward. "The causes and consequences of land use regulation: Evidence from Greater Boston." Journal of Urban Economics 65, no. 3 (2009): 265–78. http://dx.doi.org/10.1016/j.jue.2008.06.003.

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Skeer, Margie, Michelle L. Land, Debbie M. Cheng, and Michael B. Siegel. "Smoking in Boston Bars Before and After a 100% Smoke-Free Regulation." Journal of Public Health Management and Practice 10, no. 6 (2004): 501–7. http://dx.doi.org/10.1097/00124784-200411000-00005.

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Steele, Rachel R., Daniel R. Rovenpor, Brian Lickel, and Thomas F. Denson. "Emotion regulation and prejudice reduction following acute terrorist events: The impact of reflection before and after the Boston Marathon bombings." Group Processes & Intergroup Relations 22, no. 1 (2017): 43–56. http://dx.doi.org/10.1177/1368430217706182.

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Research suggests that regulating negative emotional responses to threatening events can help reduce outgroup bias. The present research examined the effect of emotion regulation strategies on outgroup bias during relatively benign versus threatening time periods. Participants were assigned to regulate their emotions (reflection, rumination, or control) while reading a reminder of a past terrorist event and then reported their anger and bias toward Muslims. The bombings at the 2013 Boston Marathon occurred during data collection, which allowed us to examine the effect of emotion regulation on

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B. Bringas, Abraham, and Arthur B. Almario. "ASSESSMENT ON THE IMPLEMENTATION OF BARANGAY MICRO BUSINESS ENTERPRISES ACT OF 2002 RELATIVE TO THE PROFITABILITY OF FOOD BUSINESSES IN VICTORIA, LAGUNA." Business, Organizations and Society 1, no. 1 (2023): 08–14. http://dx.doi.org/10.26480/bosoc.01.2023.08.14.

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Barangay Micro Business Enterprise (BMBE) law was enacted in 2002 in the Philippines to promote the growth of small and micro-enterprises in the food industry by providing tax incentives and simplified business registration procedures. This study aimed to analyze the effectiveness of BMBE implementation in the food industry, its impact on business profitability, and identify areas for improvement. A survey was conducted on 30 BMBE-registered sole proprietor food businesses in Victoria, Laguna, using a quantitative research method. The findings showed that the BMBE Act of 2002 has benefited mic

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Seller, Stephanie L., Cora Roelofs, Paul A. Shoemaker, Nancie N. Nguyen, and Tuan D. Nguyen. "Improving Boston Nail Salon Indoor Air Quality Through Local Public Health Regulation, 2007–2019." American Journal of Public Health 109, no. 12 (2019): 1711–13. http://dx.doi.org/10.2105/ajph.2019.305329.

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Ma, Xian-Yong, Wei Qiao Qiu, Caren E. Smith, et al. "Association betweenBDNFrs6265 and Obesity in the Boston Puerto Rican Health Study." Journal of Obesity 2012 (2012): 1–8. http://dx.doi.org/10.1155/2012/102942.

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Brain-derived neurotrophic factor (BDNF) has been associated with regulation of body weight and appetite. The goal of this study was to examine the interactions of a functional variant (rs6265) in theBDNFgene with dietary intake for obesity traits in the Boston Puerto Rican Health Study.BDNFrs6265 was genotyped in 1147 Puerto Rican adults and examined for association with obesity-related traits. Men (n=242) with the GG genotype had higher BMI (P=0.009), waist circumference (P=0.002), hip (P=0.002), and weight (P=0.03) than GA or AA carriers (n=94). They had twice the risk of being overweight (

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Shi, Qiang, Changhong Yan, and Peng Yu. "Simulation evaluation of groundwater resources in southeastern Bosten Lake based on GMS." E3S Web of Conferences 79 (2019): 03020. http://dx.doi.org/10.1051/e3sconf/20197903020.

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Bosten Lake is located in Yanqi Basin of Xinjiang. A working area in the southeast of China is influenced by the regulation of Bosten Lake, and the transitional zone of climate in the north and south of Xinjiang, forming a climate of large evaporation, dry and little rain, and groundwater is a very important fresh water resource. In order to find out the composition of groundwater resources in the working area, the groundwater steady flow model is established by using the data of borehole, well, pumping test and so on, and the groundwater resources in this area are evaluated. The groundwater e

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Wang, Yu, Bryan Duong, Natalia Krawczynska, et al. "Abstract C027: The role of Liver Receptor Homolog 1 (LRH-1) in regulating cancer progression by modulating the immune response." Cancer Research 84, no. 22_Supplement (2024): C027. http://dx.doi.org/10.1158/1538-7445.tumbody-c027.

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Abstract Breast cancer is a significant global health concern, being the second most common type of cancer and the second leading cause of cancer-related deaths among women in the U.S. Metastatic breast cancer is responsible for most of these deaths, and current FDA-approved immunotherapies are effective only for a small subset of patients with PD-L1-positive tumors. Thus, there is a critical need for new therapeutic targets to enhance the immune response against breast cancer. Elevated plasma cholesterol concentrations are associated with poor breast cancer outcomes. Our previous studies indi

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Letai, Anthony. "Abstract IA012: Panel Discussion 1: Regulatory and Non-Regulatory Challenges to the Wide Adoption of Precision Diagnostics." Cancer Research 85, no. 5_Supplement (2025): IA012. https://doi.org/10.1158/1538-7445.genfunc25-ia012.

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Abstract While in recent years, genomic and functional precision medicine have overcome many technical and scientific challenges, widespread adoption is often limited by factors that go well beyond the laboratory or clinic. In this session, the panel will discuss important practical and logistical challenges that continue to limit patient access to precision medicine tools in cancer. Topics will include governmental regulation, reimbursement, tissue custody, and awareness. Citation Format: Anthony Letai. Panel Discussion 1: Regulatory and Non-Regulatory Challenges to the Wide Adoption of Preci

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BODYUK, A.V. "Cost fisking to use fields of iron ores." Market Relations Development in Ukraine №2(237)2021 111 (May 26, 2021): 65–70. https://doi.org/10.5281/zenodo.4808639.

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Subject of research – Geological information on deposits of iron ores, transmitted according to official permits for use, normative legal regulation of authorization and assessment of their value. The purpose of writing the article is to justify the essence, the conceptual apparatus of value fiscal use of deposits. Methodology of work – the use of abstract–logical analysis (development of the conceptual fiscal apparatus); Legal analysis (study of the normative–legal framework); generalization (formation of monetary obligations). The results – of the work are subst

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Walker, Christopher James, Shirong Li, Yi Chai, et al. "Effects of weekly selinexor, bortezomib, dexamethasone (XVd) versus standard twice weekly bortezomib and dexamethasone (Vd) on RAS-mutated previously treated multiple myeloma (MM)." Journal of Clinical Oncology 39, no. 15_suppl (2021): 8027. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.8027.

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8027 Background: Activating mutations of the RAS genes NRAS, KRAS, and HRAS ( RASmut) occur in up to 50% of MM and portend poor survival and high recurrence rates. MM cells with RASmut are susceptible to inhibition of germinal center kinase (GCK), resulting in IKAROS degradation independent of cereblon (CRBN). Selinexor is a selective inhibitor of nuclear export (SINE) compound that can induce IKAROS degradation through CRBN-independent pathways to overcome immunomodulatory drug resistance. We explored the benefit of selinexor treatment for pts with RASmut MM. Methods: In the randomized BOSTON

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Champine, Robey B., and Sara K. Johnson. "Towards the Promotion of Positive Development among Boys in Challenging Contexts: A Mixed-Methods Study of Engagement in the Scoutreach Initiative." Journal of Youth Development 12, no. 4 (2017): 16–37. http://dx.doi.org/10.5195/jyd.2017.521.

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Engagement in youth development programs reflects the quality of young people’s program-related experiences. However, more research is needed that explores cognitive, emotional, and behavioral dimensions of engagement in programs that serve underrepresented youth of color. The present cross-sectional and mixed-methods study assessed potential relations among dimensions of engagement in the Boston-area Scoutreach initiative, character attributes, self-perceived school competence, and intentional self-regulation. We analyzed data from 32 Scouts (Mage = 9.97 years, SD = 2.46, Range = 6 to 14), 32

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Blanpain, Cédric. "Abstract IA019: Regulation of EMT tumor states by stromal cells." Cancer Research 84, no. 22_Supplement (2024): IA019. http://dx.doi.org/10.1158/1538-7445.tumbody-ia019.

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Abstract Epithelial-to-mesenchymal transition (EMT) is a reversible process during which epithelial cells lose their epithelial characteristics and acquire mesenchymal features, that are important for tumor initiation, progression, stemness, metastasis, and therapy resistance. Different EMT states, each with distinct functional properties, have been identified across various tumor models. These EMT states reside within specific physical niches, characterized by unique stromal cell populations. Understanding the cellular interactions within the tumor microenvironment (TME) and their influence o

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Gordan, John, Adriana Pitea, Rigney E. Turnham, et al. "Abstract PO017: HBV alters YAP regulation in liver cancer by remodeling PP2A complexes." Clinical Cancer Research 28, no. 17_Supplement (2022): PO017. http://dx.doi.org/10.1158/1557-3265.liverca22-po017.

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Abstract Viral hepatitis promotes hepatocellular carcinoma (HCC) initiation by inducing inflammation, cellular stress and cell death. However, the cell-intrinsic effects of viral infection in advanced HCC remain unclear. We used affinity purification mass spectrometry to develop a complete map of 145 interactions among Hepatitis B Virus (HBV) and host proteins in the HUH7 HCC tumor cell line, identifying known and novel HBV/host protein-protein interactions. We integrated this map with HCC genomes, identifying 61 proteins with preferential mutation in non-HBV HCC, suggesting that their interac

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Giuliani, Marco. "Michael D. Reagan, Regulation. The Politics of Policy, Boston, Little, Brown & Co., 1987, pp. 241, St. 12.95." Italian Political Science Review/Rivista Italiana di Scienza Politica 19, no. 1 (1989): 150–52. http://dx.doi.org/10.1017/s0048840200017585.

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Srinivasan, Sneha, Priscilla Tang, Karthikeyan Mythreye, and Nadine Hempel. "Abstract A030: Regulation of SIRT3 overexpression in anchorage independent ovarian cancer." Cancer Research 84, no. 5_Supplement_2 (2024): A030. http://dx.doi.org/10.1158/1538-7445.ovarian23-a030.

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Abstract Ovarian cancer remains the most lethal gynecological malignancy, and late-stage diagnosis and significant metastatic spread are prominent contributors to its lethality. To achieve optimal metastasis, ovarian tumor cells must modify their response to heightened oxidative stress to ensure their survival. One crucial mechanism of this modification involves the scavenging of mitochondrial superoxide anions by superoxide dismutase (SOD2). Mitochondrial Sirtuin Deacetylase 3 (SIRT3) deacetylates SOD2 to enhance its antioxidant capacity, facilitating the conversion of superoxide (O2−) to H2O

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Boutros, Paul C. "Abstract IA018: The evolutionary origins of cancer lethality." Cancer Research 85, no. 5_Supplement (2025): IA018. https://doi.org/10.1158/1538-7445.genfunc25-ia018.

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Abstract Cancer is fundamentally a disease of evolution. But why do some cancers evolve into lethal entities while others rarely if ever evolve the capacity to metastasize and become lethal? We will explore how each of the cancer genome, transcriptome, proteome, gene-regulation and microenvironment are dysregulated in ways that explain variable clinical outcomes. Taken together, these converge on an evolutionary understanding of when the capacity to become lethal emerges, and how to predict that. We will conclude by briefly discussing the underlying genetic and lifestyle factors that influence

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Berg, Sanford V. "Incentive Regulation and the Regulation of Incentivesby Glenn Blackmon(Kluwer Academic Publishers, Dordrecht and Boston, 1994), pp. x + 133, US$69.95. ISBN 0 7923 9470 4." Prometheus 14, no. 1 (1996): 113–15. http://dx.doi.org/10.1080/08109029608632026.

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Lee, Changhu, Min Kim, Chanho Park, Woobeen Jo, and Jiyoung Park. "Abstract A063: Epigenetic regulation of Neuregulin 1 promotes breast cancer progression associated to hyperglycemia." Molecular Cancer Therapeutics 22, no. 12_Supplement (2023): A063. http://dx.doi.org/10.1158/1535-7163.targ-23-a063.

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Abstract Hyperglycemia is a risk factor for breast cancer-related morbidity and mortality. Hyperglycemia induces Neuregulin 1 (Nrg1) overexpression in breast cancer, which subsequently promotes tumor progression. However, molecular mechanisms underlying hyperglycemia-induced Nrg1 overexpression remain poorly understood. Here, we show that hyperglycemia causes active histone modifications at the Nrg1 enhancer, forming enhanceosome complexes where recombination signal binding protein for immunoglobulin kappa J region (RBPJ), E1A binding protein p300 (P300), and SET domain containing 1A (SETD1A)

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Dalasanur Nagaprashantha, Lokesh Prasad Gowda, Tatjana Talamantes, Jyotsana Singhal, Sanjay Awasthi, Sharad S. Singhal, and Laszlo Prokai. "The impact of novel compound 2'-hydroxyflavanone on proteomic networks of VHL-mutant renal cell carcinoma." Journal of Clinical Oncology 30, no. 15_suppl (2012): e13557-e13557. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.e13557.

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e13557 Background: Von Hippel-Lindau (VHL) tumor suppressor is a major genetic factor that determines hypoxic acclimatization and response to therapy in renal cell carcinoma (RCC). Our initial studies revealed that 2'-Hydroxyflavanone (2HF) effectively inhibits the survival of VHL-mutant RCC. Hence, we performed proteomic analyses to study the signaling networks of clinical significance that are regulated by 2HF in VHL-mutant RCC. Methods: The 786-O cells, an established cell line from a male Caucasian patient, were provided by William Kaelin Jr., MD, Harvard Medical School, Boston, MA. The ce

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Hannifin, Sean, Ashley M. Mello, Tenzin Ngodup, Katelyn L. Donahue, Marina Pasca di Magliano, and Kyoung Eun Lee. "Abstract A038: The hypoxic regulation of macrophage function in pancreatic cancer." Cancer Research 84, no. 17_Supplement_2 (2024): A038. http://dx.doi.org/10.1158/1538-7445.pancreatic24-a038.

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Abstract Pancreatic ductal adenocarcinoma (PDAC) is marked by an extensive fibroinflammatory stroma and a low-oxygen (hypoxic) microenvironment, which contribute to disease progression and therapeutic resistance. Within the PDAC stroma, macrophages and cancer-associated fibroblasts (CAFs) are the predominant cell types. Macrophages are a major immunosuppressive population in PDAC. These cells are highly plastic and, as a result, their environment plays an important role in regulating their function. Macrophages adapt to hypoxia primarily by stabilizing hypoxia-inducible factors (HIFs), which a

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Hofmann, Stefan G., Nicola Petrocchi, James Steinberg, et al. "Loving-Kindness Meditation to Target Affect in Mood Disorders: A Proof-of-Concept Study." Evidence-Based Complementary and Alternative Medicine 2015 (2015): 1–11. http://dx.doi.org/10.1155/2015/269126.

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Conventional treatments for mood disorders primarily focus on reducing negative affect, but little on enhancing positive affect. Loving-kindness meditation (LKM) is a traditional meditation practice directly oriented toward enhancing unconditional and positive emotional states of kindness towards oneself and others. We report here two independent and uncontrolled studies carried out at different centers, one in Boston, USA (n= 10), and one in Frankfurt, Germany (n= 8), to examine the potential therapeutic utility of a brief LKM group intervention for symptoms of dysthymia and depression. Resul

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Palacios, Natalia, Tammy Scott, Neha Sahasrabudhe, Xiang Gao, and Katherine L. Tucker. "Lower Plasma Vitamin B-6 is Associated with 2-Year Cognitive Decline in the Boston Puerto Rican Health Study." Journal of Nutrition 149, no. 4 (2019): 635–41. http://dx.doi.org/10.1093/jn/nxy268.

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ABSTRACT Background Despite its important role in cognitive development and regulation of nervous system function, vitamin B-6 has been under-studied in relation to cognitive aging. Objective We investigated whether plasma pyridoxal-5'-phosphate (PLP, vitamin B-6) concentrations were associated with cognitive function and subsequent cognitive decline. Methods In a longitudinal study of 949 participants (aged 45–75 y at baseline; 70% women) from the Boston Puerto Rican Health Study cohort, we examined the association between baseline plasma PLP and baseline cognitive function and 2-y cognitive

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Kafle, Chandra Mani, and Daphne W. Bell. "Abstract B007: Investigation of the mechanism of PADI2 regulation by the FBXW7 tumor suppressor." Clinical Cancer Research 30, no. 5_Supplement (2024): B007. http://dx.doi.org/10.1158/1557-3265.endo24-b007.

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Abstract Serous endometrial cancer (SEC) is an aggressive form of cancer that frequently exhibits recurrent somatic mutations in FBXW7 at residues 465, 479, and 505. FBXW7 is a tumor suppressor and is part of a Skp1-Cullin-F-box containing (SCF) complex that targets various proteins, including certain oncoproteins, for ubiquitin-mediated proteasomal degradation. FBXW7 interacts with Cdc4 phosphodegron (CPD) motif(s) within substrate proteins. We previously reported upregulation of peptidyl arginine deiminase 2 (PADI2), a potentially druggable protein, in FBXW7-mutant SEC cell lines compared to

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Taniue, Kenzui, Yusuke Mizukami, and Nobuyoshi Akimitsu. "Abstract B059: RNA exosome component EXOSC4 amplified in multiple cancer types is required for the pancreatic cancer cell survival via the regulation of BIK and SESN2 mRNA." Cancer Research 82, no. 22_Supplement (2022): B059. http://dx.doi.org/10.1158/1538-7445.panca22-b059.

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Abstract RNA decay plays a crucial role in the post-transcriptional regulation of gene expression. The RNA exosome is a multi-subunit ribonuclease complex that is evolutionally conserved and the major cellular machinery for the surveillance, processing, degradation, and turnover of diverse RNAs essential for cell viability. The RNA exosome is composed of a catalytically inactive barrel structure of nine core subunits (known as EXO9) that achieves its catalytic activity via the interaction with the exoribonuclease exosome component 10 (EXOSC10), the exo/endo-ribonuclease DIS3, and the two DIS3-

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Turk, Branka, Ivana Dorotić Malič, and Sandra Cuculić. "Uniri Digital Library – Supporting Open Science at the University of Rijeka." BOSNIACA, no. 29 (December 24, 2024): 239–59. https://doi.org/10.37083/bosn.2024.29.239.

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Goal: The main objective of this paper is to investigate, analyse and present how the Uniri Digital Library is organised. Methodology: The paper gives an overview of important activities which the University of Rijeka Library has in cooperation with the University of Rijeka and the University constituents[1] taken to increase the number of objects stored and published in the institutional repositories. Results: The paper analyses digital objects stored and published in the Uniri Digital Library by the type of papers and openness. The analysis has identified insufficient openness of objects in

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Saha, Karabi, and Wenfeng An. "Abstract A013: Transcription initiation and its regulation in mouse L1s." Cancer Immunology Research 12, no. 10_Supplement (2024): A013. http://dx.doi.org/10.1158/2326-6074.tumimm24-a013.

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Abstract Long interspersed elements type 1 (LINE-1s or L1s) are highly abundant non-LTR retrotransposons in mammalian genomes. Apart from an evolutionary role in altering the genomic landscape and gene expression, recent discoveries have revealed the scale and impact of active movement by L1, both in the germline and in somatic niches (e.g., the brain and many cancers). As transcriptional activation is a prerequisite for L1 retrotransposition, it is important to understand how L1 transcription is regulated. L1 transcription is controlled by an internal promoter contained in the 5’ untranslated

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Bhalerao, Nikita, Jessica Peura, Yamini Ogoti, et al. "Abstract B002: Tumor-secreted PTHrP facilitates pancreatic cancer cachexia by regulation of de novo lipogenesis pathway." Cancer Research 84, no. 17_Supplement_2 (2024): B002. http://dx.doi.org/10.1158/1538-7445.pancreatic24-b002.

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Abstract Pancreatic cancer is associated with one of the highest and most severe forms of cancer- associated cachexia amongst solid tumors. In an effort to further our understanding of the molecular etiology of pancreatic cancer-associated cachexia, we have developed mouse models to study adipose tissue wasting during Pancreatic Ductal Adenocarcinoma (PDAC) progression. In these pursuits, we have identified a pro-cachectic factor, PTHrP, that is produced and secreted by PDAC tumor cells and directly signals to adipocytes to facilitate wasting. Genetic deletion and pharmacological inhibition of

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