Relevant bibliographies by topics / Botulism antitoxin

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Academic literature on the topic 'Botulism antitoxin'

Author: Grafiati
Published: 4 June 2025
Last updated: 1 August 2025

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Journal articles on the topic "Botulism antitoxin"

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Eliseeva, E. M., I. A. Mazerkina, and A. A. Chistokhina. "Neurotropic Effect of Botulinum Toxin and the Potential of Specific Serum Therapy in Botulism (Review)." Safety and Risk of Pharmacotherapy 12, no. 3 (2024): 299–308. http://dx.doi.org/10.30895/2312-7821-2024-12-3-299-308.

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INTRODUCTION. The outbreak of foodborne botulism that occurred in Russia in June 2024 once again demonstrated the danger of this rather rare but severe infectious disease caused by ingesting botulinum neurotoxin. The only aetiological treatment for botulism is currently the administration of antitoxins against various serotypes of botulinum toxin. However, antitoxins do not provide rapid regression of neurological symptoms, which may raise doubts about the effectiveness of the selected treatment option. It is impossible to assess the potential of specific treatment without understanding the me
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Ben David, Alon, Ada Barnea, Amram Torgeman, et al. "Immunologic and Protective Properties of Subunit- vs. Whole Toxoid-Derived Anti-Botulinum Equine Antitoxin." Vaccines 10, no. 9 (2022): 1522. http://dx.doi.org/10.3390/vaccines10091522.

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Botulism is a paralytic disease caused by botulinum neurotoxins (BoNTs). Equine antitoxin is currently the standard therapy for botulism in human. The preparation of equine antitoxin relies on the immunization of horses with botulinum toxoid, which suffers from low yield and safety limitations. The Hc fragment of BoNTs was suggested to be a potent antibotulinum subunit vaccine. The current study presents a comparative evaluation of equine-based toxoid-derived antitoxin (TDA) and subunit-derived antitoxin (SDA). The potency of recombinant Hc/A, Hc/B, and Hc/E in mice was similar to that of toxo
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Robinson, Renee F., and Milap C. Nahata. "Management of Botulism." Annals of Pharmacotherapy 37, no. 1 (2003): 127–31. http://dx.doi.org/10.1345/aph.1c034.

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OBJECTIVE To provide a concise review of the presentation and treatment of botulism. DATA SOURCES Searches of MEDLINE (1966–November 2001), tertiary references, and public and government Internet sites were conducted. STUDY SELECTION All articles and additional references from those articles were thoroughly evaluated. DATA SYNTHESIS Clostridium botulinum toxin blocks acetylcholine release in a dose-dependent fashion, resulting in acute symmetric diplopia, dysarthria, dysphonia, dysphagia, and possible neurologic sequelae despite the route of exposure (i.e., food-borne, wound, intestinal, inhal
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Diamant, Eran, Avi Pass, Osnat Rosen, et al. "A Novel Rabbit Spirometry Model of Type E Botulism and Its Use for the Evaluation of Postsymptom Antitoxin Efficacy." Antimicrobial Agents and Chemotherapy 62, no. 4 (2018): e02379-17. http://dx.doi.org/10.1128/aac.02379-17.

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ABSTRACTBotulinum neurotoxins (BoNTs), the most poisonous substances known in nature, pose significant concern to health authorities. The only approved therapeutic for botulism is antitoxin. While administered to patients only after symptom onset, antitoxin efficacy is evaluated in animals mostly in relation to time postintoxication regardless of symptoms. This is most likely due to the difficulty in measuring early symptoms of botulism in animals. In this study, a rabbit spirometry model was developed to quantify early respiratory symptoms of type E botulism that were further used as a trigge
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Hung, Le Quoc, Vo Ngoc Anh Tho, Do Thi Ngoc Khanh, et al. "Suspected botulism outbreak after the consumption of vegetarian pâté in the south of Viet Nam." Wellcome Open Research 5 (June 18, 2021): 257. http://dx.doi.org/10.12688/wellcomeopenres.16372.4.

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Botulism and other botulinum neurotoxins-producing clostridia are potentially life-threatening diseases caused by toxins produced by Clostridium botulinum. Here we reported a case series of six patients who presented with botulism following ingestion of commercially made pâté. The key features of presentation were acute onset of bilateral cranial nerve palsies and symmetrical descending weakness in the absence of fever resulting in the need for mechanical ventilation in all six patients. The clinical diagnosis of botulism was confirmed through the identification of C. botulinum from the suspec
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Hung, Le Quoc, Vo Ngoc Anh Tho, Do Thi Ngoc Khanh, et al. "Botulism outbreak after the consumption of vegetarian pâté in the south of Viet Nam." Wellcome Open Research 5 (January 26, 2021): 257. http://dx.doi.org/10.12688/wellcomeopenres.16372.3.

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Botulism is a potentially life-threatening disease caused by toxins produced by Clostridium botulinum. Here we reported a case series of six patients who presented with botulism following ingestion of commercially made pâté. The key features of presentation were acute onset of bilateral cranial nerve palsies and symmetrical descending weakness in the absence of fever resulting in the need for mechanical ventilation in all six patients. The clinical diagnosis of botulism was confirmed through the identification of C. botulinum from the suspected food source. Given that botulinum antitoxin was n
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Ngan, Nguyen Thi Thuy, Vo Ngoc Anh Tho, Do Thi Ngoc Khanh, et al. "Botulism outbreak after the consumption of vegetarian pâté in the south of Viet Nam." Wellcome Open Research 5 (October 27, 2020): 257. http://dx.doi.org/10.12688/wellcomeopenres.16372.1.

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Botulism is a potentially life-threatening disease caused by toxins produced by Clostridium botulinum. Here we reported a case series of six patients who presented with botulism following ingestion of commercially made pâté. The key features of presentation were acute onset of bilateral cranial nerve palsies and symmetrical descending weakness in the absence of fever resulting in the need for mechanical ventilation in all six patients. The clinical diagnosis of botulism was confirmed through the identification of C. botulinum from the suspected food source. Given that botulinum antitoxin was n
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Ngan, Nguyen Thi Thuy, Vo Ngoc Anh Tho, Do Thi Ngoc Khanh, et al. "Botulism outbreak after the consumption of vegetarian pâté in the south of Viet Nam." Wellcome Open Research 5 (December 23, 2020): 257. http://dx.doi.org/10.12688/wellcomeopenres.16372.2.

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Botulism is a potentially life-threatening disease caused by toxins produced by Clostridium botulinum. Here we reported a case series of six patients who presented with botulism following ingestion of commercially made pâté. The key features of presentation were acute onset of bilateral cranial nerve palsies and symmetrical descending weakness in the absence of fever resulting in the need for mechanical ventilation in all six patients. The clinical diagnosis of botulism was confirmed through the identification of C. botulinum from the suspected food source. Given that botulinum antitoxin was n
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Dembek, Zygmunt F., Leonard A. Smith, and Janice M. Rusnak. "Botulism: Cause, Effects, Diagnosis, Clinical and Laboratory Identification, and Treatment Modalities." Disaster Medicine and Public Health Preparedness 1, no. 2 (2007): 122–34. http://dx.doi.org/10.1097/dmp.0b013e318158c5fd.

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ABSTRACTBotulism is a neuroparalytic disease caused by neurotoxins produced by the bacteriaClostridium botulinum. Botulinum neurotoxins (BoNTs) are among the most potent naturally occurring toxins and are a category A biological threat agent. The 7 toxin serotypes of BoNTs (serotypes A–G) have different toxicities, act through 3 different intracellular protein targets, and exhibit different durations of effect. Botulism may follow ingestion of food contaminated with BoNT, from toxin production ofC botulinumpresent in the intestine or wounds, or from inhalation of aerosolized toxin. Intoxicatio
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Raza, Nadia, Sandhya Dhital, Valerie Elise Espinoza, et al. "Wound Botulism in Black Tar Heroin Injecting Users: A Case Series." Journal of Investigative Medicine High Impact Case Reports 9 (January 2021): 232470962110280. http://dx.doi.org/10.1177/23247096211028078.

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The incidence of wound botulism in injection drug users has increased since the introduction of black tar heroin. Many species of the Clostridium genus, most commonly Clostridium botulinum, Clostridium baratii, and Clostridium butyricum, have been associated with wound botulism. Patients often present with progressive bulbar weakness, including dysphagia, cranial nerve palsies, and loss of speech, in addition to symmetrical descending weakness of the upper extremities that may progress to the chest and lower extremities. In this article, we present 3 cases of wound botulism, in which the patie
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Books on the topic "Botulism antitoxin"

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Mix, Monica. Botulism. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199976805.003.0064.

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Botulism, caused by exposure to the botulinum toxin, is characterized by a symmetric, flaccid, and descending paralysis. There are four naturally occurring forms of botulism—foodborne botulism, infant botulism, adult intestinal botulism, and wound botulism—and two forms that require intentional manipulation of the toxin by humans: inhalational and iatrogenic botulism. All six forms are rare. The treatment for botulism is botulinum antitoxin: an equine-derived formulation for adults and a human-source formulation for infants. Even more important than early antitoxin delivery is early diagnosis
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Book chapters on the topic "Botulism antitoxin"

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Franz, David R., Louise M. Pitt, Michael A. Clayton, Martha A. Hanes, and Kenneth J. Rose. "Efficacy of Prophylactic and Therapeutic Administration of Antitoxin for Inhalation Botulism." In Botulinum and Tetanus Neurotoxins. Springer US, 1993. http://dx.doi.org/10.1007/978-1-4757-9542-4_52.

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Thalley, B. S., M. B. van Boldrik, S. B. Carroll, W. Tepp, B. R. DasGupta, and D. C. Stafford. "Development of an Avian Antitoxin to Type A Botulinum Neurotoxin." In Botulinum and Tetanus Neurotoxins. Springer US, 1993. http://dx.doi.org/10.1007/978-1-4757-9542-4_51.

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Conference papers on the topic "Botulism antitoxin"

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Chuan En Loh, Ann, Ann Chuan En Loh, Terrence Gerard Sundram Thomas, Matthias Maiwald, Xue Fen Valerie Seah, and Natalie Woon Hui Tan. "354 Case of infant botulism and review of the use of heptavalent botulinum antitoxin for treatment." In RCPCH Conference Singapore. BMJ Publishing Group Ltd, 2021. http://dx.doi.org/10.1136/bmjpo-2021-rcpch.193.

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