Relevant bibliographies by topics / Bqcap

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  1. Journal articles
  2. Dissertations / Theses

Academic literature on the topic 'Bqcap'

Author: Grafiati
Published: 15 February 2025
Last updated: 31 July 2025

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Journal articles on the topic "Bqcap"

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Ma, Lei, Matthew A. Seager, Marion Wittmann, et al. "Selective activation of the M1 muscarinic acetylcholine receptor achieved by allosteric potentiation." Proceedings of the National Academy of Sciences 106, no. 37 (2009): 15950–55. http://dx.doi.org/10.1073/pnas.0900903106.

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The forebrain cholinergic system promotes higher brain function in part by signaling through the M1 muscarinic acetylcholine receptor (mAChR). During Alzheimer's disease (AD), these cholinergic neurons degenerate, therefore selectively activating M1 receptors could improve cognitive function in these patients while avoiding unwanted peripheral responses associated with non-selective muscarinic agonists. We describe here benzyl quinolone carboxylic acid (BQCA), a highly selective allosteric potentiator of the M1 mAChR. BQCA reduces the concentration of ACh required to activate M1 up to 129-fold
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Pavlov, Valentin, Mahendar Ochani, Meghan Dancho, Yousef Al-Abed, Neil Nathanson, and Kevin Tracey. "Positive allosteric modulation of M1 muscarinic acetylcholine receptors suppresses lethal peripheral inflammation (P5082)." Journal of Immunology 190, no. 1_Supplement (2013): 180.24. http://dx.doi.org/10.4049/jimmunol.190.supp.180.24.

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Abstract Peripheral inflammation can be regulated by activation of brain muscarinic acetylcholine receptor (mAChR)-dependent signaling functionally associated with a vagus-nerve mediated anti-inflammatory circuit (Proc Natl Acad Sci USA, 2006, 5219; Brain Behav Immun, 2009, 23:41). Here, we studied the specific role of the M1 mAChR subtype in this regulation by utilizing BQCA, a highly specific allosteric M1 mAChR activator that crosses the blood-brain barrier. Single drug (5,10 or 20 mg/kg, i.p) administration in mice 1h prior to endotoxin (8 mg/kg, i.p.) dose-dependently reduced serum and sp
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Khatwal, Rizwan Basha, Anil Dubala, Jayasankar Kosaraju, et al. "Pharmacokinetics and tissue distribution of a M1 muscarinic acetylcholine receptor positive allosteric potentiator, benzyl quinolone carboxylic acid." Anal. Methods 6, no. 8 (2014): 2672–78. http://dx.doi.org/10.1039/c4ay00102h.

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Avila, Olga Beatriz, Liliana Ester Contini, and Stefanía D´Iorio. "RENDIMIENTO ACADÉMICO EN ESTADÍSTICA, ¿CÓMO IMPACTAN EN ÉL LAS DISTINTAS ESTRATEGIAS DE ENSEÑANZA SEGÚN LOS PLANES DE ESTUDIO?" Revista Binacional Brasil-Argentina: Diálogo entre as ciências 11, no. 02 (2022): 82–97. http://dx.doi.org/10.22481/rbba.v11i02.11582.

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Durante los últimos cinco años, en la Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe-Argentina, un equipo de docentes investigadores ha trabajado en la implementación, de la estrategia “Enseñanza por proyectos” en Estadística en las carreras de Licenciatura en Nutrición (LN) , Licenciatura en Biotecnología (LB) y Bioquímica (Bqca). En este trabajo se muestra la evolución del rendimiento de los alumnos desde el año 2016 (dictado convencional con clases de teoría y práctica) hasta el año 2021 donde se fue poniendo en práctica de manera paulatina (incluid
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Tichenor, MT(ASCP), Patricia H., Barbara M. Eiland, MT(ASCP), Cari E. Reed, MT(ASCP), et al. "The Effect of Lupus Anticoagulant in the Second-Generation Assay for Activated Protein C Resistance." American Journal of Clinical Pathology 119, no. 1 (2003): 66–71. http://dx.doi.org/10.1309/1gn6-ntm7-bqap-8vkx.

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Ma, Lei, Marlene A. Jacobson, Constantine Kreatsoulas, Krista L. Getty, Guy R. Seabrook, and William J. Ray. "P4-322: Exploring the pharmacology of BQCA, a highly selective allosteric M1 potentiator." Alzheimer's & Dementia 4 (July 2008): T767. http://dx.doi.org/10.1016/j.jalz.2008.05.2392.

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Chintamaneni, Pavan Kumar, Praveen Thaggikuppe Krishnamurthy, and Sai Kiran S. S. Pindiprolu. "Polysorbate-80 surface modified nano-stearylamine BQCA conjugate for the management of Alzheimer's disease." RSC Advances 11, no. 10 (2021): 5325–34. http://dx.doi.org/10.1039/d1ra00049g.

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Niklas, Beata, Bruno Lapied, and Wieslaw Nowak. "In Search of Synergistic Insect Repellents: Modeling of Muscarinic GPCR Interactions with Classical and Bitopic Photoactive Ligands." Molecules 27, no. 10 (2022): 3280. http://dx.doi.org/10.3390/molecules27103280.

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Insect vector-borne diseases pose serious health problems, so there is a high demand for efficient molecules that could reduce transmission. Using molecular docking and molecular dynamics (MD) simulation, we studied a series of compounds acting on human and insect muscarinic acetylcholine receptors (mAChRs), a novel target of synergistic agents in pest control. We characterized early conformational changes of human M1 and fruit fly type-A mAChR G protein-coupled receptors (GPCRs) in response to DEET, IR3535, and muscarine binding based on the MD analysis of the activation microswitches known t
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Wakeham, Matthew C. L., Briana J. Davie, David K. Chalmers, et al. "Structural Features of Iperoxo–BQCA Muscarinic Acetylcholine Receptor Hybrid Ligands Determining Subtype Selectivity and Efficacy." ACS Chemical Neuroscience 13, no. 1 (2021): 97–111. http://dx.doi.org/10.1021/acschemneuro.1c00572.

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Wittmann, Marion, Guangping Xu, Michelle Pearson, et al. "P4-332: In vivo pharmacodynamic effects of BQCA, a novel selective allosteric M1 receptor modulator." Alzheimer's & Dementia 4 (July 2008): T770. http://dx.doi.org/10.1016/j.jalz.2008.05.2402.

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Dissertations / Theses on the topic "Bqcap"

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Al, Samrout Marwa. "Approches mono et bi-objective pour l'optimisation intégrée des postes d'amarrage et des grues de quai dans les opérations de transbordement." Electronic Thesis or Diss., Normandie, 2024. http://www.theses.fr/2024NORMLH21.

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Le transport maritime international est vital pour le commerce mondial, représentant plus de 85 % des échanges, avec 10,5 milliards de tonnes transportées chaque année. Ce mode de transport est le plus économique et durable, contribuant seulement à 2,6 % des émissions de CO2. En France, le secteur maritime représente 1,5 % du PIB et près de 525 000 emplois. Les ports maritimes, cruciaux pour la chaîne logistique, facilitent le transbordement des marchandises et adoptent de plus en plus des solutions numériques basées sur l'intelligence artificielle pour améliorer leur efficacité. La France com
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Vykoukalová, Nikol. "Predikce průchodu takrin-BQCA derivátů přes hematoencefalickou bariéru." Master's thesis, 2017. http://www.nusl.cz/ntk/nusl-370985.

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Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmacology & Toxicology Student: Nikol Vykoukalová Supervisor: prof. PharmDr. František Štaud, Ph.D. Title of diploma thesis: Prediction of tacrine-BQCA derivatives across blood-brain-barrier This master thesis deals with the determination of permeability prediction for tacrine BQCA derivatives, potential drugs for Alzheimer's disease, through the blood-brain barrier (BBB) using the method of parallel artificial membrane penetration (PAMPA). We attempted to predict the central bioavailability by the permeability coefficie
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