Academic literature on the topic 'Bradykinina'

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Journal articles on the topic "Bradykinina"

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Śliż, Daniel. "Kiedy z punktu widzenia internisty warto zastosować acemetacynę?" Medycyna Faktów 16, no. 2(59) (2023): 204–7. http://dx.doi.org/10.24292/01.mf.0223.11.

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Niesteroidowe leki przeciwzapalne są powszechnie stosowane w łagodzeniu bólu i stanów zapalnych w różnych schorzeniach. Częstość i nasilenie bólu wzrastają wraz z wiekiem, co sprawia, że osoby starsze są bardziej zależne od leczenia przeciwbólowego. Celem tego podsumowania jest przedstawienie skuteczności i profilu bezpieczeństwa acemetacyny w porównaniu z innymi niesteroidowymi lekami przeciwzapalnymi.Acemetacyna wyróżnia się dobrym profilem bezpieczeństwa i skutecznością w łagodzeniu bólu i stanów zapalnych. Oprócz hamowania COX-1 i COX-2 lek ten wpływa również na mediatory stanu zapalnego,
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Przewłocka, Barbara, and Joanna Starnowska-Sokół. "Novel hybrid compounds designed by Polish scientists provide a long-lasting analgesic effect in a mouse model of neuropathic pain." BÓL 20, no. 2 / Zjazd PTBB (2019): 1–3. http://dx.doi.org/10.5604/01.3001.0013.4610.

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W polskich i niektórych europejskich mediach pojawiło się w ostatnim okresie wiele informacji na temat opracowanej przez polskich naukowców nowej substancji proponowanej jako lek przeciwbólowy. Ze względu na fakt, że badania te prowadzone były pod moim kierunkiem, podjęłam decyzję, aby czytelnikom kwartalnika „Ból” umożliwić zapoznanie się z genezą i wynikiem tych badań. Punktem wyjścia do wyżej wspomnianych badań, przeprowadzonych w Zakładzie Farmakologii Bólu Instytutu Farmakologii im. J. Maja Polskiej Akademii Nauk, była obserwacja, że po wielokrotnym podawaniu opioidów rozwija się toleranc
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Willars, Gary B., Werner Müller-Esterl, and Stefan R. Nahorski. "Receptor phosphorylation does not mediate cross talk between muscarinic M3 and bradykinin B2 receptors." American Journal of Physiology-Cell Physiology 277, no. 5 (1999): C859—C869. http://dx.doi.org/10.1152/ajpcell.1999.277.5.c859.

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This study examined cross talk between phospholipase C-coupled muscarinic M3 and bradykinin B2 receptors coexpressed in Chinese hamster ovary (CHO) cells. Agonists of either receptor enhanced phosphoinositide signaling (which rapidly desensitized) and caused protein kinase C (PKC)-independent, homologous receptor phosphorylation. Muscarinic M3 but not bradykinin B2 receptors were also phosphorylated after phorbol ester activation of PKC. Consistent with this, muscarinic M3 receptors were phosphorylated in a PKC-dependent fashion after bradykinin B2 receptor activation, but muscarinic M3 recept
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Ma, Jie, Yu Luo, Lilin Ge, et al. "Ranakinestatin-PPF from the Skin Secretion of the Fukien Gold-Striped Pond Frog,Pelophylax plancyi fukienensis: A Prototype of a Novel Class of BradykininB2Receptor Antagonist Peptide from Ranid Frogs." Scientific World Journal 2014 (2014): 1–9. http://dx.doi.org/10.1155/2014/564839.

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The defensive skin secretions of many amphibians are a rich source of bradykinins and bradykinin-related peptides (BRPs). Members of this peptide group are also common components of reptile and arthropod venoms due to their multiple biological functions that include induction of pain, effects on many smooth muscle types, and lowering systemic blood pressure. While most BRPs are bradykinin receptor agonists, some have curiously been found to be exquisite antagonists, such as the maximakinin gene-related peptide, kinestatin—a specific bradykinin B2-receptor antagonist from the skin of the giant
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Dixon, B. S., R. Breckon, J. Fortune, et al. "Effects of kinins on cultured arterial smooth muscle." American Journal of Physiology-Cell Physiology 258, no. 2 (1990): C299—C308. http://dx.doi.org/10.1152/ajpcell.1990.258.2.c299.

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The present study uses various kinin agonists and antagonists to examine the cellular mechanisms of bradykinin's actions on intracellular calcium, prostaglandins, and adenosine 3',5'-cyclic monophosphate (cAMP) accumulation in cultured arterial smooth muscle cells (casmc) obtained from rat mesenteric arteries. Exposure to bradykinin produced a rapid release of calcium (peak less than or equal to 20 s) from intracellular stores and an increase in prostaglandin (PG) E2 and cAMP production in casmc. Compared with bradykinin, the bradykinin B1-agonist [des-Arg9]BK produced only a small increase in
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Morgan-Boyd, R., J. M. Stewart, R. J. Vavrek, and A. Hassid. "Effects of bradykinin and angiotensin II on intracellular Ca2+ dynamics in endothelial cells." American Journal of Physiology-Cell Physiology 253, no. 4 (1987): C588—C598. http://dx.doi.org/10.1152/ajpcell.1987.253.4.c588.

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The purpose of this study was to investigate the effects of angiotensin II and bradykinin on intracellular Ca2+ dynamics in cultured endothelial cells. We used the "second-generation" fluorescent Ca2+ indicator fura-2, in conjunction with dual-wavelength fluorescence spectroscopy, in cultured adherent pulmonary arterial endothelial cells. Angiotensin II (up to 2 microM) had no consistent effect on intracellular Ca2+ levels. In contrast, bradykinin (10 nM) elicited a transient increase of cytosolic free Ca2+, from the resting value of 37 +/- 5 to 647 +/- 123 nM, followed by a decline to a stead
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Pan, H. L., C. L. Stebbins, and J. C. Longhurst. "Bradykinin contributes to the exercise pressor reflex: mechanism of action." Journal of Applied Physiology 75, no. 5 (1993): 2061–68. http://dx.doi.org/10.1152/jappl.1993.75.5.2061.

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This study determined the receptors responsible for mediating bradykinin's effect on skeletal muscle afferents that cause the pressor reflex in anesthetized cats. In eight cats, 1 microgram of bradykinin was injected intra-arterially into the gracilis muscle before and after intravenous injection of a kinin B2-receptor antagonist (NPC 17731, 20 micrograms/kg). Initial injection of bradykinin reflexly increased mean arterial pressure by 23 +/- 7 mmHg, maximal change in pressure over time by 439 +/- 272 mmHg/s, and heart rate by 11 +/- 4 beats/min. The hemodynamic response to bradykinin was abol
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CUGNO, Massimo, Francesco SALERNO, Jürg NUSSBERGER, Bianca BOTTASSO, Elettra LORENZANO, and Angelo AGOSTONI. "Bradykinin in the ascitic fluid of patients with liver cirrhosis." Clinical Science 101, no. 6 (2001): 651–57. http://dx.doi.org/10.1042/cs1010651.

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Bradykinin, a nonapeptide with vasodilatory and permeabilizing activity, is generated through the cleavage of high-Mr (‘high-molecular-weight’) kininogen by kallikrein, and its generation is facilitated by plasmin. In the ascitic fluid of patients with cirrhosis, there is massive cleavage of high-Mr kininogen and activation of fibrinolysis, but bradykinin has never been measured directly. In the ascitic fluid of 24 patients with cirrhosis, we measured bradykinin-(1-9)-nonapeptide levels by RIA after liquid-phase and subsequent HPLC extraction, and those of its catabolic product bradykininin-(1
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Gouda, Ahmed S., and Bruno Mégarbane. "Molecular Bases of Serotonin Reuptake Inhibitor Antidepressant-Attributed Effects in COVID-19: A New Insight on the Role of Bradykinins." Journal of Personalized Medicine 12, no. 9 (2022): 1487. http://dx.doi.org/10.3390/jpm12091487.

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Widely available effective drugs to treat coronavirus disease-2019 (COVID-19) are still limited. Various studies suggested the potential contribution of selective serotonin-reuptake inhibitor (SSRI) antidepressants to alleviate the clinical course of COVID-19. Initially, SSRI antidepressant-attributed anti-COVID-19 activity was attributed to their direct agonistic or indirect serotonin-mediated stimulation of sigma-1 receptors (Sig1-R). Thereafter, attention was drawn to the property of SSRI antidepressants to decrease ceramide production, as functional inhibitors of acid sphingomyelinase. Cer
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Todoriko, L. D. "Problem issues of the pathogenesis of inflammatory reaction and the course of coronavirus infection." Tuberculosis, Lung Diseases, HIV Infection, no. 1 (March 23, 2021): 76–86. http://dx.doi.org/10.30978/tb2021-1-76.

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Objective — to analysis and systematization of literature data about pathogenesis of the inflammatory reaction and the clinical course of coronavirus infection caused by SARS-CoV-2.
 Materials and methods. Access to various full-text and abstract databases was used for the search query «coronavirus», «COVID-19», «SARS-CoV-2» and their systematic evaluation was carried out. The most complete database of available literature sources (about 70) was obtainedon the molecular pathophysiology of COVID-19.
 Results and discussion. The results of the analysis of the molecular pathophysiology
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Dissertations / Theses on the topic "Bradykinina"

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Bouhadfane, Mouloud. "Propriétés électriques bistables des motoneurones de la moelle épinière : Identification des mécanismes ioniques sous-jacents." Thesis, Aix-Marseille, 2014. http://www.theses.fr/2014AIXM5030/document.

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La posture, composante statique du contrôle moteur permettant une position érigée du corps, repose sur une décharge tonique des motoneurones innervant nos muscles antigravitaires. La décharge prend la forme de « potentiel de plateau » au niveau de motoneurones matures chez de nombreux vertébrés. Pour déterminer une éventuelle concordance entre l'émergence des propriétés de plateau et le développement postural, notre travail a eu pour but d'étudier la maturation et la nature ionique des potentiels de plateau des motoneurones innervant le muscle triceps surae (extenseur de la cheville) chez le r
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Parsopoulou, Faidra. "Biomarqueurs pronostiques et prédictifs de la sévérité de l'angioedème héréditaire." Thesis, Université Grenoble Alpes, 2020. http://www.theses.fr/2020GRALV041.

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L’expression clinique de l’angioedème héréditaire C1-INH-AOH est hétérogène. L'identification de biomarqueurs et la disponibilité de tests biologiques pourraient rendre compte de cette observation. Ainsi, notre travail a retenu quatre points:I. L'expression des récepteurs de la bradykinine. Les récepteurs B1 et B2 sont des cibles thérapeutiques potentielles. Par les ligands fluorescents spécifiques pour B1 et B2, nous avons cherché à quantifier les récepteurs pour leur expression sur les lignées EA.hy926 et THP1, pour examiner l’expression sur les cellules endothéliales des patients en conditi
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ILLIANO, STEPHANE. "Bradykinine et paroi veineuse." Strasbourg 1, 1993. http://www.theses.fr/1993STR15068.

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UENO, Tomoyuki, Yasuko KOZAKI, and Kazue MIZUMURA. "Increased Expression of mRNA for B1 and B2 Bradykinin Receptors in the Skin of Adjuvant Inoculated Rats." Research Institute of Environmental Medicine, Nagoya University, 2002. http://hdl.handle.net/2237/2787.

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Daffix, Isabelle. "Synthèse d'analogues peptidiques et pseudopeptidiques de la bradykinine." Montpellier 2, 1996. http://www.theses.fr/1996MON20230.

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La these est consacree a la synthese d'analogues peptidiques et pseudopeptidiques de la bradykinine ; l'evaluation pharmacologique des composes synthetises a ete realisee principalement in vitro. Nous nous sommes interesses, dans un premier temps, a l'elaboration d'une sonde radiomarquee selective des recepteurs b#1 de la bradykinine, utile a l'etude pharmacologique et la caracterisation de ces recepteurs, ainsi que dans une strategie de criblage a haut debit de drogues selectives de ces recepteurs. Dans une deuxieme partie, le travail a ete consacre a la synthese d'analogues de la bradykinine
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Bedos, Philippe. "Synthèse et étude pharmacologique d'antagonistes pseudopeptidiques du récepteur B1 de la bradykinine." Montpellier 2, 2000. http://www.theses.fr/2000MON20010.

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La bradykinine (bk) est une hormone peptidique endogene de 9 aminoacides intervenant au niveau physiologique dans de nombreux phenomenes tels que la bronchoconstriction, la vasodilatation ou le declenchement du signal douloureux. A ce jour 2 recepteurs de la bk ont ete clones : les recepteurs b 1 et b 2. Grace au developpement d'antagonistes selectifs puissants, l'implication des kinines a ete mise en evidence au niveau pathologique dans les phenomenes de douleur et d'inflammation. Le recepteur b 1 intervient notamment lors des inflammations de type rhinites allergiques ou infectieuses ou lors
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Dion, Daniel. "Hyperfiltration splanchnique en dialyse péritonéale aiguë chez le rat diabétique : un rôle pour les kinines?" Sherbrooke : Université de Sherbrooke, 2002.

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Willer, Elizabeth Jane. "Control of B2 bradykinin receptor gene expression." Thesis, University College London (University of London), 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.286487.

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Owen, Penelope Jane. "Bradykinin stimulation of bovine adrenal chromaffin cells." Thesis, University of Leicester, 1991. http://hdl.handle.net/2381/33600.

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Cultured bovine adrenal chromaffin cells provide a useful model of stimulus secretion coupling and respond to cholinergic agonists by secreting catecholamines. Work in this thesis concentrates on the responses to a non-cholinergic agonist, bradykinin. Bradykinin as shown to stimulate a two phase, dose dependent increase in catecholamine release which is mediated by a receptor of the B2 subtype. Calcium entry is shown to be required for release to occur but studies with various calcium channel blockers suggest that, in contrast to the response to potassium, a non-voltage sensitive calcium chann
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Bawolak, Marie-Thérèse. "Étude de la régulation de l'expression du récepteur B1 de la bradykinine." Thesis, Université Laval, 2007. http://www.theses.ulaval.ca/2007/24699/24699.pdf.

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Books on the topic "Bradykinina"

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1955-, Burch Ronald M., ed. Bradykinin antagonists: Basic and clinical research. Dekker, 1991.

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Burch, Ronald M. Molecular biology and pharmacology of bradykinin receptors. R.G. Landes, 1993.

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Silva, M. Rocha e 1910- and Rothschild Adolfo Max, eds. Contributions to autacoid pharmacology: A festschrift in honour of Maurício Rocha e Silva. Birkhäuser Verlag, 1992.

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Keely, Stephen J. Regulation of colonic ion transport in vitro. University College Dublin, 1995.

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Sharma, Jagdish N. Topics in mediator pharmacology. Nova Science Publishers, 2011.

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Universitetet i Linköping. Division of Medical Microbiology and Universitetet i. Linköping, eds. Pharmacological interactions between angiotensin-converting enzyme (ACE) inhibitors, bradykinin and nitric oxide. Division of Pharmacology, Department of Medicine and Care, Faculty of Health Sciences, Linköping University, 2000.

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Ellard, John. Studies towards the synthesis of L-755,807: A novel, non-peptide bradykinin antagonist. typescript, 2000.

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1954-, Farmer Stephen G., ed. The Kinin system. Academic Press, 1997.

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Tebbatt, Anne M. Studies towards the synthesis of the ring system of non-peptide bradykinin antagonist L-755,807, and its analogues. typescript, 2000.

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München, Universität, ed. Pathophysiologie der experimentellen Pneumokokkenmeningitis: Untersuchungen zur Bedeutung der Leukozyten-Endothelzell-Interaktion und der entzündlichen Mediatoren Hydroxylradikal und Bradykinin. [s.n.], 1999.

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Book chapters on the topic "Bradykinina"

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Seth, John. "Bradykinin." In The Immunoassay Kit Directory. Springer Netherlands, 1994. http://dx.doi.org/10.1007/978-94-011-1414-1_7.

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Farmer, Stephen G. "Bradykinin." In Airways Smooth Muscle: Peptide Receptors, Ion Channels and Signal Transduction. Birkhäuser Basel, 1995. http://dx.doi.org/10.1007/978-3-0348-7362-8_2.

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Gooch, Jan W. "Bradykinin." In Encyclopedic Dictionary of Polymers. Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4419-6247-8_13280.

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Sales, Vicência, and João Bosco Pesquero. "Bradykinin Receptors." In Encyclopedia of Signaling Molecules. Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-67199-4_232.

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Saidak, Zuzana, Zakaria Ezzoukhry, Jean-Claude Maziere, et al. "Bradykinin Receptors." In Encyclopedia of Signaling Molecules. Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4419-0461-4_232.

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Vavrek, Raymond J., Lajos Gera, and John M. Stewart. "Pseudopeptide Analogs of Bradykinin and Bradykinin Antagonists." In Recent Progress on Kinins. Birkhäuser Basel, 1992. http://dx.doi.org/10.1007/978-3-0348-7321-5_69.

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Floccard, Bernard, Jullien Crozon, Brigitte Coppere, Laurence Bouillet, and Bernard Allaouchiche. "Bradykinin-Mediated Angioedema." In Uncommon Diseases in the ICU. Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-04576-4_16.

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Inoki, R., and T. Kudo. "Bradykinin and enkephalins." In Dynamic Aspects of Dental Pulp. Springer Netherlands, 1990. http://dx.doi.org/10.1007/978-94-009-0421-7_25.

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Snyder, Solomon H., Donald C. Manning, and Larry R. Steranka. "Bradykinin and Pain." In Molecular and Cellular Aspects of the Drug Addictions. Springer New York, 1989. http://dx.doi.org/10.1007/978-1-4613-8817-3_3.

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Floccard, B., E. Hautin, and B. Allaouchiche. "Bradykinin-mediated Angioedema." In Annual Update in Intensive Care and Emergency Medicine 2012. Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-25716-2_46.

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Conference papers on the topic "Bradykinina"

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Hewitt, Matthew M., and Brendan J. Canning. "MECHANISMS OF BRADYKININ EVOKED COUGH." In American Thoracic Society 2010 International Conference, May 14-19, 2010 • New Orleans. American Thoracic Society, 2010. http://dx.doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a5548.

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Müller, E., A. Henschen, and G. Wunderer. "IDENTIFICATION OF A NEW HUMAN KININ, ILE-SER-BRADYKININ, BY HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY AND SEQUENCE ANALYSIS IN OVARIAN CARCINOMA ASCITES." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1642848.

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Human blood has been shown to contain two different kinin precursors, i.e0 the high and the low molecular mass kininogen0 These two kininogens release the same kinins, with the starting sequences Met-Lys-Arg-Pro-, Lys-Arg-Pro- or just Arg-Pro-depending on the releasing enzyme. The kinin starting with Arg-Pro- is denoted as bradykinin. In rats a different kininogen, called T-kininogen, is also present, especially as the major acute-phase protein in this species. The corresponding kinin, T-kinin, has the starting sequence Ile-Ser-Arg-Pro-. This type of kininogen or kinin has previously never bee
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Rattu, Mohammad A., and Eric A. Maddock. "Quincke’s Phenomenon – The ACE Inhibitor Culprit." In 28th Annual Rowan-Virtua Research Day. Rowan University Libraries, 2024. http://dx.doi.org/10.31986/issn.2689-0690_rdw.stratford_research_day.85_2024.

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Angioedema is defined as a non-pitting edema that involves the subcutaneous layer and additionally may include submucosal layers of tissue which pertain to the face, oral cavity, larynx, lips, extremities and gastrointestinal tract; this becomes a life-threatening situation particularly when there is involvement of the larynx. Angioedema may be classified as either histamine-mediated or bradykinin-mediated. Histamine-mediated, associated with mast-cell and basophil activation, is the most common. Bradykinin-mediated (secondary to hereditary, acquired C1-inhibitor deficiency, ACEI-associated an
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Kempe, S., J. Hahn, M. Jerg, C. Brunner, TK Hoffmann, and J. Greve. "Molecular mechanisms of bradykinin-induced angioedema." In Abstract- und Posterband – 89. Jahresversammlung der Deutschen Gesellschaft für HNO-Heilkunde, Kopf- und Hals-Chirurgie e.V., Bonn – Forschung heute – Zukunft morgen. Georg Thieme Verlag KG, 2018. http://dx.doi.org/10.1055/s-0038-1639742.

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Marceau, François. "Maximakinin: An amphibian bradykinin homologue integrated into fusion proteins that bind to the bradykinin B2 receptor." In 7th International Electronic Conference on Medicinal Chemistry. MDPI, 2021. http://dx.doi.org/10.3390/ecmc2021-11403.

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Egberg, Nils, Krister Gréen, Jan Jacobsson, Ole Vester-gvist, Bjöm Wiman, and Michael Gallimore. "EFFECTS OF PLASMA KALLIKREIN AND BRADYKININ ON FIBRINOLYSIS AND THROMBOXANE PROSTACYKLIN FORMATION STUDIED IN MINIPIGS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644334.

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The effect of plasma kallikrein and bradykinin infusions into pigs on hemodynamic and hemostatic variables have been investigated. Both substances caused a pronounced decrease of the systemic blood pressure. The leucocyte count in periferal blood fell markedly, reaching a minimun within one hour after infusion of either of the substances.Signs that could be interpreted as a progressive disseminated intravascular coagulation with decrease of fibrinogen and platelet count was observed after kallikrein as well as bradykinin infusions. A pronounced increase of the plasma tissue plasminogen activat
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Dimitrova, Nevena, Robin Lochbaum, Angelina Gierke, Janina Hahn, Thomas Hoffmann, and Jens Greve. "Bradykinin vermindert Proliferation und Wundheilung primärer Endothelzellen." In 94. Jahresversammlung Deutsche Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie e.V., Bonn. Georg Thieme Verlag, 2023. http://dx.doi.org/10.1055/s-0043-1766439.

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Lee, Yeon Sun, Sara M. Hall, Cyf Ramos-Colon, et al. "[Des-Arg7]-Dynorphin A Analogs for Bradykinin-2 Receptor." In The Twenty-Third American and the Sixth International Peptide Symposium. Prompt Scientific Publishing, 2013. http://dx.doi.org/10.17952/23aps.2013.134.

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Lopes, Flavio A., Jones M. Silva, Maria Luiza V. Oliva, and Antonio Miranda. "Bauhinia Bauhinioides Kallikrein Inhibitor Fragments with Bradykinin-Like Activities." In The 24th American Peptide Symposium. Prompt Scientific Publishing, 2015. http://dx.doi.org/10.17952/24aps.2015.082.

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Hahn, J., M. Nordmann, TK Hoffmann, et al. "Ulmer Notfallalgorithmus: Therapie von Medikamenten-induzierten, Bradykinin vermittelten Angioödemen." In Abstract- und Posterband – 89. Jahresversammlung der Deutschen Gesellschaft für HNO-Heilkunde, Kopf- und Hals-Chirurgie e.V., Bonn – Forschung heute – Zukunft morgen. Georg Thieme Verlag KG, 2018. http://dx.doi.org/10.1055/s-0038-1639735.

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Reports on the topic "Bradykinina"

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กาญจนทัต, อภิชาติ. โปรตีนไฮโดรไลเสตจากเมล็ดผลไม้ไทยเพื่อการบำบัดโรค : รายงานวิจัยฉบับสมบูรณ์ (ปีที่ 1). จุฬาลงกรณ์มหาวิทยาลัย, 2014. https://doi.org/10.58837/chula.res.2014.89.

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Abstract:
Blood pressure regulation is partially dependent on the renin-angiotensin system; renin acts on angiotensinogen to release angiotensin-I, which is further converted into the angiotensin II by the angiotensin I-converting enzyme (ACE). ACE plays a key physiological role in the regulation of blood pressure by virtue of two different reactions that it catalyzes: conversion of the inactive angiotensin I to the powerful vasoconstrictor angiotensin II, and inactivation of the vasodilator bradykinin. Crude extract and ammonium sulphate cut protein extracts, and their pepsin-pancreatin hydrolysates, f
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