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Dissertations / Theses on the topic 'Brain function'

Author: Grafiati
Published: 4 June 2021
Last updated: 25 July 2025

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1

Tidswell, Alexander Thomas. "Functional Electrical Impedance Tomography of adult and neonatal brain function." Thesis, University College London (University of London), 2006. http://discovery.ucl.ac.uk/1445123/.

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Electrical Impedance Tomography (EIT) is a fast, portable imaging technique that produces tomographic images of the internal impedance of an object from surface electrode measurements. This thesis reports the first use of EIT to image evoked brain activity in adults and neonates and determines whether accurate EIT images could be obtained from the adult and neonatal brain. In addition, a realistic head-tank phantom was developed to test the performance of EIT with known impedance changes placed within a real human skull. Two EIT systems were used. Images were obtained using 31 or 21 Ag/AgCl EE
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2

Deshpande, Gopikrishna. "Nonlinear and network characterization of brain function using functional MRI." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2007. http://hdl.handle.net/1853/24760.

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Thesis (Ph.D.)--Biomedical Engineering, Georgia Institute of Technology, 2007.<br>Committee Chair: Hu, Xiaoping; Committee Member: Brummer, Marijn; Committee Member: Butera, Robert; Committee Member: Oshinski, John; Committee Member: Sathian, Krish.
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3

McCorry, N. K. "Prenatal prediction of postnatal brain function." Thesis, Queen's University Belfast, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.411140.

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4

MacLullich, Alasdair Maurice Joseph. "Cognitive function, the brain and glucocorticoids." Thesis, University of Edinburgh, 2003. http://hdl.handle.net/1842/24879.

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Several domains of cognitive function show lower mean scores and increasing variability with increasing age. Little is known about the biological mechanisms underlying these changes. There is evidence, largely from animal studies, that prolonged exposure to high levels of glucocorticoids is associated with (a) atrophy of brain regions known to be essential for cognitive functioning, such as the hippocampus, and (b) decrements in cognitive function with ageing. There are few human studies examining these links. The studies in this thesis were aimed at testing the hypotheses that elevated levels
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5

Nakao, Akito. "Elucidation of Ca[2+] channel function in higher brain function." 京都大学 (Kyoto University), 2014. http://hdl.handle.net/2433/192194.

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6

Schott, Geoffrey. "Picturing the functions of the brain : 20th century graphic illustration of brain function ; observations and critical analysis." Thesis, Royal College of Art, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.262785.

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7

Kinnunen, K. M. "Traumatic brain injury : relationships between brain structural abnormalities and cognitive function." Thesis, Goldsmiths College (University of London), 2011. http://research.gold.ac.uk/6498/.

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Traumatic brain injury (TBI) is the leading cause of disability in young adults and a major public health problem. Persistent cognitive impairments are common, and constitute a significant source of long-term disability. The specific pathophysiological mechanisms underlying these impairments remain poorly understood. As it disconnects brain networks, white matter damage can be a key determinant of cognitive impairment after TBI. Neuroimaging and neuropsychological methods were employed to explore the relationships between indices of brain structure and cognitive function. The participants were
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8

LaRoux, Charlene I. 1979. "Executive function deficits in traumatic brain injury." Thesis, University of Oregon, 2010. http://hdl.handle.net/1794/11063.

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xii, 98 p. : ill. (some col.)<br>The short and long term pathophysiology of traumatic brain injury (TBI) has not been fully elucidated. Individuals recently suffering a mild TBI (mTBI) or having a history of TBI frequently suffer deficits in their ability to maintain and allocate attention within and between tasks. This dissertation examines the influence of mild and chronic TBI on performance of task switching. We employed spatial and numerical task switching paradigms to assess the behavioral deficits in mTBI, and we used an internally generated switching and an externally cued switching tas
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9

Yu, Yingwei. "Computational role of disinhibition in brain function." [College Station, Tex. : Texas A&M University, 2006. http://hdl.handle.net/1969.1/ETD-TAMU-1762.

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10

Furmark, Tomas. "Social Phobia. From Epidemiology to Brain Function." Doctoral thesis, Uppsala University, Department of Psychology, 2000. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-546.

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<p>Social phobia is a disabling anxiety disorder characterized by an excessive fear of negative evaluation in social situations. The present thesis explored the epidemiology and neurobiology of the disorder. By means of a mailed questionnaire, the point prevalence of social phobia in the Swedish general population was estimated at 15.6%. However, prevalence rates varied between 1.9 and 20.4% across the different levels of distress and impairment used to define cases. Thus, although social anxiety is widespread within the community, the precise diagnostic boundaries for social phobia are diffic
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11

Young, A. H. "Hormonal effects on brain 5-HT function." Thesis, University of Edinburgh, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.664142.

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The purpose of the work carried out in this thesis was to examine hormonal effects on central nervous system serotonergic (5-hydroxtryptamine; 5-HT) receptor function. Experiments were carried out using established rodent (mouse and rat) models of central 5-HT receptor function. Corticosteroids were administered, both acutely and chronically, and the effects on these models assessed. Corticosteroids were found to have relatively selective effects: in the mouse and rat certain models of 5-HT<SUB>1A</SUB> receptor function were attenuated and in the mouse corticosteroids enhanced behavioural mod
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12

Nayak, Sahana. "Synthetic and function of DHEA in brain." Thesis, University of Nottingham, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298961.

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13

Saygin, Zeynep Mevhibe. "Structure-function relationships in human brain development." Thesis, Massachusetts Institute of Technology, 2012. http://hdl.handle.net/1721.1/77843.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Brain and Cognitive Sciences, 2012.<br>This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.<br>Cataloged from student-submitted PDF version of thesis. Page 125 blank.<br>Includes bibliographical references.<br>The integration of anatomical, functional, and developmental approaches in cognitive neuroscience is essential for generating mechanistic explanations of brain function. In this thesis, I first establish a proof-of-principle that n
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14

Bentley, P. I. "Effects of cholinesterase inhibition on brain function." Thesis, University College London (University of London), 2011. http://discovery.ucl.ac.uk/1301395/.

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Pharmacological-functional imaging provides a non-invasive method by which the actions of neurotropic drugs on the human brain can be explored. Simply put, it assesses how neural activity patterns associated with cognitive functions of interest are modified by a drug challenge. Since one of the most widely-used cognitive-enhancing drugs in clinical practice are cholinesterase inhibitors, this thesis applies pharmacological functional imaging to the question of understanding how such drugs work - both in healthy people and dementia. The experiments in this thesis describe how brain activations
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15

Enfield, Louise C. "Electrical impedance tomography of human brain function." Thesis, University College London (University of London), 2005. http://discovery.ucl.ac.uk/1446415/.

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Electroencephalography (EEG) has been used for over 70 years to record the electrical signals of the brain. Electrical impedance tomography (EIT) is a more recent imaging technique which when applied to brain function and structure has the potential to provide a rapid portable bedside neuroimaging device. The purpose of this work has been to investigate several applications of EIT and EEG in the imaging of brain function. EEG does not always give the required spatial information, especially if the current generator is in the deep brain structures such as the hypothalamus. Dipole source localis
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16

Soni, Garcia Adriana Lorena. "Latin American teachers' perceptions about the mind-brain relationship, brain function and neuroeducation." Thesis, University of Bristol, 2016. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.723455.

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17

Trachtenberg, Aaron J. "The effects of APOE genotype on brain function." Thesis, University of Oxford, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.542982.

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18

Vogiatzoglou, Anna. "Vitamin B12 status : determinants, biomarkers and brain function." Thesis, University of Oxford, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.526422.

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19

Cahill, Louise Margaret. "Motor speech function following childhood traumatic brain injury /." [St. Lucia, Qld.], 2002. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe16948.pdf.

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20

Elgh, Eva. "Neuropsychological Function in Relation to Structural and Functional Brain Changes in Alzheimer’s Disease." Doctoral thesis, Umeå universitet, Geriatrik, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-323.

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The aim of this doctoral thesis was to study neuropsychological function in relation to structural and functional brain changes in Alzheimer´s disease (AD). In the first study relations between hippocampal volume, neuropsychological function and limbic-hypothalamic-pituitary-adrenal (LHPA) axis disturbances in AD were investigated with magnetic resonance imaging (MRI). Reduced hippocampal CA1 volume and suppressed cortisol levels in combination, best predicted the variation in neuropsychological performance. The conclusion was that reduced hippocampal volume and LHPA axis disturbances are asso
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21

Elgh, Eva. "Neuropsychological function in relation to structural and functional brain changes in Alzheimer's disease /." Umeå : Geriatric medicine, Department of community medicine and rehabilitation, Umeå University, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-323.

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22

Olesen, Pernille J. "Brain function and behaviour related to development and training of working memory /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-506-2/.

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23

Lind, Johanna. "Memory, genes, and brain imaging : relating the APOE gene to brain function and structure /." Stockholm : Karolinska institutet, 2007. http://diss.kib.ki.se/2007/978-91-7357-110-4/.

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24

Lima, Brasil Fabricio [Verfasser], and Niels [Akademischer Betreuer] Birbaumer. "Brain-Machine Interfaces and Plasticity of Brain Function / Fabricio Lima Brasil ; Betreuer: Niels Birbaumer." Tübingen : Universitätsbibliothek Tübingen, 2019. http://d-nb.info/1194370411/34.

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25

Driessen, Anique Johanna Eduarda. "Exploring the combined use of electrical and hemodynamic brain activity to investigate brain function." Thesis, Oxford Brookes University, 2014. https://radar.brookes.ac.uk/radar/items/d5e7c357-e312-4fba-8cc5-774eff36180e/1/.

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This thesis explored the relationship between electrical and metabolic aspects of brain functioning in health and disease, measured with QEEG and NIRS, in order to evaluate its clinical potential. First the limitations of NIRS were investigated, depicting its susceptibility to different types of motion artefacts and the inability of the CBSI-method to remove them from resting state data. Furthermore, the quality of the NIRS signals was poor in a significant portion of the investigated sample, reducing clinical potential. Different analysis methods were used to explore both EEG and NIRS, and th
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26

Martindale, Anthony John. "Investigating the relationship between neural activity and the haemodynamic response : modelling, theory and experiment." Thesis, University of Sheffield, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.269397.

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27

Tranberg, Mattias. "N-acetylaspartate in brain : studies on efflux and function /." Göteborg : Institute of Neuroscience and Physiology, Department of Physiology, The Sahlgrenska Academy, Göteborg University, 2006. http://hdl.handle.net/2077/718.

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28

Podjaski, Cornelia. "Netrins enhance blood-brain barrier function and regulate immune responses at the blood-brain barrier." Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=116977.

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During development, netrin guidance cues control cell motility and cell adhesion. Cell-adhesion between endothelial cells at the blood-brain barrier makes the endothelium impermeable to blood-derivatives and immune cells. To establish and maintain this barrier during development, and adulthood, and as well as during disease, brain endothelial cells must develop and sustain these strong adhesive contacts, through expression of tight junction molecules. However, we do not know whether netrins support inter-endothelial cell adhesion at the blood-brain barrier. Given this, we hypothesize that netr
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29

Sellers, Kathleen Walworth. "Role of brain soluble epoxide hydrolase in cardiovascular function." [Gainesville, Fla.] : University of Florida, 2004. http://purl.fcla.edu/fcla/etd/UFE0008356.

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Thesis (Ph.D.)--University of Florida, 2004.<br>Typescript. Title from title page of source document. Document formatted into pages; contains 156 pages. Includes Vita. Includes bibliographical references.
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30

Zemanová, Lucia. "Structure-function relationship in hierarchical model of brain networks." Phd thesis, Universität Potsdam, 2007. http://opus.kobv.de/ubp/volltexte/2008/1840/.

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The mammalian brain is, with its numerous neural elements and structured complex connectivity, one of the most complex systems in nature. Recently, large-scale corticocortical connectivities, both structural and functional, have received a great deal of research attention, especially using the approach of complex networks. Here, we try to shed some light on the relationship between structural and functional connectivities by studying synchronization dynamics in a realistic anatomical network of cat cortical connectivity. We model the cortical areas by a subnetwork of interacting excitable neur
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31

Kokotilo, Kristen J. "Reorganization of brain function during force production after stroke." Thesis, University of British Columbia, 2008. http://hdl.handle.net/2429/2723.

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Damage to motor areas of the brain, caused by stroke, can produce devastating motor deficits, including aberrant control of force. After stroke, reorganization of the brain’s motor system has been identified as one of the fundamental mechanisms involved in recovery of motor control after stroke. Yet, few studies have investigated how force production and modulation are encoded in the brain after stroke and how this relates to motor outcome. Thus, the purpose of this study was to (1) understand how past neuroimaging literature has contributed to establishing common patterns of brain reorganizat
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32

Odontiadis, John. "Effects of nutritional manipulation on brain 5-HT function." Thesis, Oxford Brookes University, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.397093.

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33

Cheyne, Christopher Paul. "Multivariate modelling of cognitive function and brain structural data." Thesis, University of Liverpool, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.569125.

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Previous studies have investigated links between cognitive ability and a number of factors including age, gender, handedness, musical ability as well as the volume and surface area of certain brain structures, However, in these studies either the explanatory variables are analysed independently of each other, or the investigation is based on a separate analysis for individual cognitive outcomes (e.g. language, visuospatial, etc.) The main objectives of this thesis are(1) to develop general multivariate models, which include mixed-effects terms, to account for the correlation in the data, (2) t
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34

黃德興 and Tak-hing Michael Wong. "Brain function and structure in violent metally abnormal offenders." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1999. http://hub.hku.hk/bib/B31981719.

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35

Holloway, Victoria. "Investigations of sensorimotor function in children with brain disease." Thesis, University College London (University of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.326156.

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36

Krishnaswamy, Pavitra. "Algorithms for enhanced spatiotemporal imaging of human brain function." Thesis, Massachusetts Institute of Technology, 2014. http://hdl.handle.net/1721.1/95844.

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Thesis: Ph. D., Harvard-MIT Program in Health Sciences and Technology, 2014.<br>This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.<br>Cataloged from student-submitted PDF version of thesis.<br>Includes bibliographical references (pages 123-142).<br>Studies of human brain function require technologies to non-invasively image neuronal dynamics with high spatiotemporal resolution. The electroencephalogram (EEG) and magnetoencephalogram (MEG) measure neuronal activity with high temporal resolution, and
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37

Chang, Jessica T. (Jessica Tzung-Min). "The formation and function of the brain ventricular system." Thesis, Massachusetts Institute of Technology, 2012. http://hdl.handle.net/1721.1/72618.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2012.<br>This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.<br>Cataloged from student submitted PDF version of thesis.<br>Includes bibliographical references.<br>The brain ventricular system is composed of a highly conserved set of cavities that contain cerebrospinal fluid (CSF), a protein-rich fluid essential for brain function. However, little is known about the function of embryonic CSF (eCSF), or the mechanisms of CSF prod
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38

Bahuguna, Jyotika. "Structure-Dynamics relationship in basalganglia: Implications for brain function." Doctoral thesis, KTH, Beräkningsvetenskap och beräkningsteknik (CST), 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-186262.

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In this thesis, I have used a combination of computational models such as mean field and spikingnetwork simulations to study various sub-circuits of basal ganglia. I first studied the striatum(chapter 2), which is the input nucleus of basal ganglia. The two types of Medium SpinyNeurons (MSNs), D1 and D2-MSNs, together constitute 98% of the neurons in striatum. Thecomputational models so far have treated striatum as a homogenous unit and D1 and D2 MSNs asinterchangeable subpopulations. This implied that a bias in a Go/No-Go decision is enforced viaexternal agents to the striatum (eg. cortico-st
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39

Brolin, Erika. "Growth hormone in the brain : Focus on cognitive function." Doctoral thesis, Uppsala universitet, Institutionen för farmaceutisk biovetenskap, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-317305.

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Cognitive impairments are an increasing health problem worldwide. In the developed countries, the average life expectancy has dramatically increased over the last decades, and with an elderly population more cases of cognitive impairments appear. Age, genetics, and different medical conditions such as diabetes mellitus, and substance use disorders may all contribute to declined cognitive ability. Physiological functions also decrease with increasing age, as does the activity of the growth hormone (GH)/insulin-like growth factor-1 (IGF-1) axis. Interestingly, both GH and IGF-1 are recognized fo
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40

Smallman, Richard. "Schizotypy and the association with brain function and structure." Thesis, University of Manchester, 2012. https://www.research.manchester.ac.uk/portal/en/theses/schizotypy-and-the-association-with-brain-function-and-structure(c8f5a318-5a89-412d-b422-1eedb80e43f6).html.

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Introduction: Schizotypy is a personality trait that shares some of the characteristics of clinical disorders such as schizophrenia. Similarities are found in expression of psychotic-like experiences and presence of attenuated negative signs. Furthermore, schizotypal samples are associated with impairments in cognitive tasks, albeit in a less comprised form. For these reasons and others, schizotypy is considered a part of the extended-phenotype of schizophrenia and as such can be utilised as an analogue sample without some of theconfounds associated with illness. Objective: The aim of the PhD
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41

Wong, Tak-hing Michael. "Brain function and structure in violent metally abnormal offenders." Hong Kong : University of Hong Kong, 1999. http://sunzi.lib.hku.hk/hkuto/record.jsp?B21254163.

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42

Powell, Howell William Robert. "Investigating brain structure and function in temporal lobe epilepsy." Thesis, University College London (University of London), 2007. http://discovery.ucl.ac.uk/1446099/.

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Background Anterior temporal lobe resection (ATLR) is increasingly used in the treatment of patients with refractory temporal lobe epilepsy (TLE). Complications of surgery include a decline in language and memory abilities, and visual field defects. The principal aim of this thesis was to use magnetic resonance imaging (MRI) techniques to improve the planning of effective surgical treatment for patients with TLE by using functional MRI to localise areas in the brain involved in language and memory function, and MR-tractography to investigate the structural connections of these areas and those
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43

Yanochko, Gina Marie. "Structure and function of the Drosophila protein Big Brain." Diss., The University of Arizona, 2001. http://hdl.handle.net/10150/279810.

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big brain is a neurogenic gene which, when mutated causes defects in cell fate determination during Drosophila neurogenesis through an unknown mechanism. The protein Big Brain (BIB) has sequence identity with the Major Intrinsic Protein family including the water- and ion-conducting Aquaporin channels. We show here that BIB expressed heterologously in Xenopus oocytes is a non-selective monovalent cation channel with permeability to K⁺ > Na⁺ >> TEA⁺. BIB macroscopic conductance, activated in response to endogenous oocyte signaling pathways, was decreased after treatment with 20μM insulin and w
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44

Carr, Sheryl Teresa. "Insulin and Ketones: Their Roles in Brain Mitochondrial Function." BYU ScholarsArchive, 2017. https://scholarsarchive.byu.edu/etd/6810.

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The prevalence of both Type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD) is increasing worldwide, and the trends are unfortunately expected to continue. AD has recently been tied with mitochondrial dysfunction and insulin resistance, creating a mechanistic tie between AD and T2DM. Unfortunately, insulin resistance is often increased with aging and therefore, all individuals are at risk of brain mitochondrial dysfunction. Without proper mitochondrial function, the brain will degenerate, causing impaired cognitive function and reduced quality of life. The purpose of this study is two-
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45

Ruiz, Susan Michelle Mosher. "Gender differences in brain function and structure in alcoholism." Thesis, Boston University, 2012. https://hdl.handle.net/2144/32050.

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Thesis (Ph.D.)--Boston University<br>PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.<br>Traditionally, alcoholism research focusing on the brain included only men. Recently, inclusion of women in brain-based alcoholism research has shown that gender differences in physiology and drinking habits
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46

Arichi, Tomoki. "Characterisation of the Haemodynamic Response Function (HRF) in the neonatal brain using functional MRI." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/14422.

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Background: Preterm birth is associated with a marked increase in the risk of later neurodevelopmental impairment. With the incidence rising, novel tools are needed to provide an improved understanding of the underlying pathology and better prognostic information. Functional Magnetic Resonance Imaging (fMRI) with Blood Oxygen Level Dependent (BOLD) contrast has the potential to add greatly to the knowledge gained through traditional MRI techniques. However, it has been rarely used with neonatal subjects due to difficulties in application and inconsistent results. Central to this is uncertainit
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47

Soehnlen, Steve G. "A Rat Model of Sleep Deprivation Prior to Traumatic Brain Injury." Cleveland State University / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=csu1304627398.

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48

Breen, Mara E. "The identification and function of English prosodic features." Thesis, Massachusetts Institute of Technology, 2007. http://hdl.handle.net/1721.1/40974.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Brain and Cognitive Sciences, 2007.<br>Includes bibliographical references (leaves 98-102).<br>This thesis contains three sets of studies designed to explore the identification and function of prosodic features in English. The first set of studies explores the identification of prosodic features using prosodic annotation. We compared inter-rater agreement for two current prosodic annotation schemes, ToBI (Silverman, et al., 1992) and RaP (Dilley & Brown, 2005) which provide guidelines for the identification of English prosodic fe
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49

Vernon, Amanda Ph D. Massachusetts Institute of Technology. "Enhanced striatal glutamatergic function upon chronic antipsychotic action." Thesis, Massachusetts Institute of Technology, 2019. https://hdl.handle.net/1721.1/132750.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Brain and Cognitive Sciences, June, 2019<br>Cataloged from the PDF version of thesis.<br>Includes bibliographical references (pages 186-208).<br>Schizophrenia is a psychiatric disorder characterized by multiple clusters of symptoms including positive symptoms, such as hallucinations and delusions, negative symptoms, such as decreased motivation and flattened affect, and cognitive symptoms, such as memory impairment and impaired executive function. Currently available antipsychotics mitigate some symptoms of schizophrenia, par
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50

Lai, Kam-ming. "Structure and function of 5'-nucleotidase of the rat brain /." [Hong Kong : University of Hong Kong], 1991. http://sunzi.lib.hku.hk/hkuto/record.jsp?B12986343.

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