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Dissertations / Theses on the topic 'Brain maps'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Song, Zheng. "The organization of motor maps in the human brain." Thesis, Lyon 1, 2015. http://www.theses.fr/2015LYO10173/document.

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Ce travail s'intéresse à l'organisation fonctionnelle du système sensorimoteur. La somatotopie est une caractéristique essentielle de M1, mais l'organisation fonctionnelle des autres aires motrices (PM, SMA, et IPL) n'est pas encore clairement établie. Premièrement, nous avons exploré par IRMf l'organisation fonctionnelle sensorimotrice chez des sujets sains exécutant des mouvements simples. Nos résultats montrent que les représentations motrices sont organisées selon des synergies musculaires et qu'une organisation somatotopique, différente de celle de M1, existe dans l'IPL. Bien qu'elle fass

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2

Farley, Brandon J. (Brandon James). "Principles underlying the development and organization of feature maps in the visual cortex." Thesis, Massachusetts Institute of Technology, 2006. http://hdl.handle.net/1721.1/38521.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Brain and Cognitive Sciences, February 2007.<br>This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.<br>Includes bibliographical references (leaves 139-142).<br>A fundamental question in neuroscience is how sensory information is represented in the brain. In particular, what principles guide the spatial organization of neurons with regard to their receptive field properties, and how is this organization established mechanistically? The v

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3

Andrew, Colin Murray. "Computation and display of EEG spectral and event-related desynchronization topographic maps." Thesis, University of Cape Town, 1992. http://hdl.handle.net/11427/26326.

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4

Kim, Nathan. "CORRELATING PERFUSION MRI MAPS WITH TREATMENT PLANS FOR RE‐RADIATION THERAPY IN BRAIN TUMOR PATIENTS." Thesis, The University of Arizona, 2015. http://hdl.handle.net/10150/528207.

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A Thesis submitted to The University of Arizona College of Medicine - Phoenix in partial fulfillment of the requirements for the Degree of Doctor of Medicine.<br>Significance: Contrast‐enhanced (CE) and Fluid attenuation inversion recovery (FLAIR) MRI are current standard of care tools for delineating radiation treatment targets in high‐grade glioma (HGG) patients. However, in the setting of retreatment, tumor regrowth and non‐tumor therapy‐related inflammation, known as post‐treatment radiation effect (PTRE), have identical MRI appearances. As a result, FLAIR MRI can be an unreliable tool for

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5

Roppelt, Christopher [Verfasser], and Virginia [Akademischer Betreuer] Flanagin. "Maps and memories of space in the human brain / Christopher Roppelt ; Betreuer: Virginia Flanagin." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2020. http://d-nb.info/1215500041/34.

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6

Park, Hyeongdong. "Brain-body interactions in conscious experience : linking subjectivity, neural maps of visceral organs, and visual consciousness." Thesis, Paris 6, 2014. http://www.theses.fr/2014PA066055.

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Rapporter 'j'ai vu le stimulus' est la marque de la vision consciente et implique deux caractéristiques fondamentales de l'expérience consciente, à savoir son aspect qualitatif et la subjectivité. L'aspect qualitatif correspond à la perception vive du stimulus, alors que la subjectivité correspond à la conscience implicite que j'ai fait l'expérience du stimulus. Afin de déterminer les bases neurales de la subjectivité, nous introduisons le concept de cadre neural subjectif ('neural subjective frame') qui correspond aux mécanismes biologiques définissant le sujet en tant qu'une entité biologiqu

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7

Saal, Martin [Verfasser], Katrin [Gutachter] Amunts, and Simon B. [Gutachter] Eickhoff. "Two new areas in the human frontal operculum: cytoarchitecture, stereotaxic maps and brain function / Martin Saal ; Gutachter: Katrin Amunts, Simon B. Eickhoff." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2019. http://d-nb.info/1193727049/34.

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8

Rizzo, Gaia. "Development of novel computational algorithms for quantitative voxel-wise functional brain imaging with positron emission tomography." Doctoral thesis, Università degli studi di Padova, 2012. http://hdl.handle.net/11577/3422179.

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Positron Emission Tomography (PET) allows to study, in vivo, important biological processes in both animals and humans. In particular, it is widely used for receptor studies, where it allows quantitative functional imaging of physiological parameters in terms of receptor binding, volume of distribution, and/or receptor occupancy. In this thesis an overview on kinetic modeling in PET is presented, as well as some novel methodologies for voxel wise quantification of PET data, applied on various datasets. The proposed methods are a good alternative for the generation of reliable parametric maps

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9

Hickie, Katharine Mabie. "An Examination of Student Performance in Reading/Language and Mathematics after Two Years of Thinking Maps® Implementation in Three Tennessee Schools." Digital Commons @ East Tennessee State University, 2006. https://dc.etsu.edu/etd/2243.

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The purpose of this study was to determine what, if any, association exists between Thinking Maps® instruction and student achievement in fifth grade students in Reading/Language and Mathematics as reported by the State NCE scores of the criterion referenced portion of the Tennessee Comprehensive Assessment Program (TCAP) Achievement Test in 3 Title I elementary schools in northeast Tennessee. The association was examined after 2 years of Thinking Maps® implementation and instruction. Using a quantitative design, the quasiexperimental study included fifth grade students' State NCE scores from

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10

Garazdiuk, M. S. "Temporal dynamics of maps of the module of complex degree of mutual polarization of microscopic images of brain histological sections for establishment of time of hemorrhages formation." Thesis, БДМУ, 2022. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/19314.

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11

Purwani, Sri. "Ensemble registration : combining groupwise registration and segmentation." Thesis, University of Manchester, 2016. https://www.research.manchester.ac.uk/portal/en/theses/ensemble-registration-combining-groupwise-registration-and-segmentation(5f3c06b4-4909-492b-bbc9-a0fecb77d216).html.

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Registration of a group of images generally only gives a pointwise, dense correspondence defined over the whole image plane or volume, without having any specific description of any common structure that exists in every image. Furthermore, identifying tissue classes and structures that are significant across the group is often required for analysis, as well as the correspondence. The overall aim is instead to perform registration, segmentation, and modelling simultaneously, so that the registration can assist the segmentation, and vice versa. However, structural information does play a role in

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12

Madl, Tamas. "Bayesian mechanisms in spatial cognition : towards real-world capable computational cognitive models of spatial memory." Thesis, University of Manchester, 2016. https://www.research.manchester.ac.uk/portal/en/theses/bayesian-mechanisms-in-spatial-cognition-towards-realworld-capable-computational-cognitive-models-of-spatial-memory(665d1016-b841-47de-9b2d-40ddd8a0ff0d).html.

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Existing computational cognitive models of spatial memory often neglect difficulties posed by the real world, such as sensory noise, uncertainty, and high spatial complexity. On the other hand, robotics is unconcerned with understanding biological cognition. This thesis takes an interdisciplinary approach towards developing cognitively plausible spatial memory models able to function in realistic environments, despite sensory noise and spatial complexity. We hypothesized that Bayesian localization and error correction accounts for how brains might maintain accurate location estimates, despite

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13

Bright, Sue-Ann. "Brain drain, exodus and chicken run : media discourses on emigration." Thesis, Rhodes University, 2005. http://hdl.handle.net/10962/d1007672.

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This paper explores the discourses of emigration in a South African daily newspaper from 1988 to 2001, and discusses the implications of these discourses on the way in which emigration is constructed within South African society In this paper, Potter and Wetherell 's (1987) approach to discourse analysis is utilized. It makes use of interpretative repertoires, to explore the functions and consequences of the discourses. The discursive framework thereby reveals the different subject positions related to nationalism, race and class. It is argued that economics and notions of culture and social c

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14

Olivero, Daniel. "Traumatic brain injury biomarker discovery using mass spectrometry imaging of 3D neural cultures." Thesis, Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/41102.

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Biomarker research is of great interest in the field of traumatic brain injury (TBI), since there are numerous potential markers that may indicate central nervous system damage, yet the brain is normally well isolated and discovery is at its infancy. Traditional methods for biomarker discovery include time consuming multi step chromatographic mass spectrometery (MS) techniques or pre-defined serial probing using traditional assays, making the identification of biomarker panels limiting and expensive. These shortfalls have motivated the development of a MS based probe that can be embedded into

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15

Mukerji, Shibani Sharon. "Activin A Reduces Brain Injury After Stroke." Case Western Reserve University School of Graduate Studies / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=case1228061151.

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16

Mörén, Lina. "Metabolomics and proteomics studies of brain tumors : a chemometric bioinformatics approach." Doctoral thesis, Umeå universitet, Kemiska institutionen, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-111309.

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The WHO classification of brain tumors is based on histological features and the aggressiveness of the tumor is classified from grade I to IV, where grade IV is the most aggressive. Today, the correlation between prognosis and tumor grade is the most important component in tumor classification. High grade gliomas, glioblastomas, are associated with poor prognosis and a median survival of 14 months including all available treatments. Low grade meningiomas, usually benign grade I tumors, are in most cases cured by surgical resection. However despite their benign appearance grade I meningiomas ca

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17

Malcomson, Elizabeth. "Reactive Oxygen Species (ROS) Up-regulates MMP-9 Expression Via MAPK-AP-1 Signaling Pathway in Rat Astrocytes." Thesis, Université d'Ottawa / University of Ottawa, 2011. http://hdl.handle.net/10393/19828.

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Ischemic stroke is characterized by a disruption of blood supply to a part of the brain tissue, which leads to a focal ischemic infarct. The expression and activity of MMP-9 is increased in ischemic stroke and is considered to be one of the main factors responsible for damages to the cerebral vasculature, resulting in compromised blood-brain barrier (BBB) integrity. However, the regulatory mechanisms of MMP-9 expression and activity are not well established in ischemic stroke. Since hypoxia/ischemia and reperfusion generates reactive oxygen species (ROS), I hypothesize that ROS is one of fact

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18

Khacef, Lyes. "Exploration du calcul bio-inspiré avec des architectures neuromorphiques auto-organisées." Thesis, Université Côte d'Azur, 2020. http://www.theses.fr/2020COAZ4085.

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La plasticité corticale du cerveau est l'une des principales caractéristiques qui nous permettent d'apprendre et de nous adapter à notre environnement. En effet, le cortex cérébral a la capacité de s'auto-organiser grâce à deux formes de plasticité : la plasticité structurelle qui crée ou coupe les connexions synaptiques entre les neurones, et la plasticité synaptique qui modifie la force des connexions synaptiques. Ces mécanismes sont très probablement à la base d'une caractéristique extrêmement intéressante du développement du cerveau humain : l'association multimodale. Malgré la diversité d

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19

Souza, Edna Marina de 1982. "Utilização dos mapas de coeficiente aparente de difusão para o diagnóstico de tumores cerebrais in vivo." [s.n.], 2011. http://repositorio.unicamp.br/jspui/handle/REPOSIP/258960.

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Orientadores: Eduardo Tavares Costa, Gabriela Castellano<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Engenharia Elétrica e de Computação<br>Made available in DSpace on 2018-08-19T05:34:48Z (GMT). No. of bitstreams: 1 Souza_EdnaMarinade_M.pdf: 4414073 bytes, checksum: bbe8987220fdc40a9373938439cb0a49 (MD5) Previous issue date: 2011<br>Resumo: Em geral, processos patológicos tais como as transformações neoplásicas das células tendem a alterar a magnitude da organização estrutural do tecido pela reorganização ou destruição de elementos membranosos ou por alteraçõ

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20

Puni, Vishal. "Head & neck circumference ratio and body mass index as possible risk factors for concussions." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=112346.

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Two anthropometric measurements were evaluated as possible risk factors for concussions among university contact-sport athletes: head and neck circumference ratio (HNCR) and body mass index (BMI). Athletes (N=575) competing in intercollegiate football, hockey, and soccer were followed prospectively for concussions over a 4-year period. A total of 86 concussions occurred, with a higher incidence among the female athletes. For HNCR, there was no consistent association observed with the exception of female hockey players. For BMI, there was no consistent association observed with the exception of

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21

Zhang, Yifan. "Metabolic Energy Balances in Ketotic Rat Brain." Case Western Reserve University School of Graduate Studies / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=case1370371336.

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22

Sihlbom, Carina. "Mass spectrometry for comparative proteomics of degenerative and regenerative processes in the brain /." Göteborg : Institute of Biomedicine, Sahlgrenska Academy, Göteborg University, 2006. http://hdl.handle.net/2077/774.

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23

Barbosa, Jeam Haroldo Oliveira. "Conteúdo de íons paramagnéticos no cérebro e sua correlação com mapas quantitativos de ressonância magnética." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/59/59135/tde-24042017-213315/.

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Mapas quantitativos de ressonância magnética (RM) têm sido propostos para quantificar a concentração in vivo de ferro no cérebro. Contudo, a especificidade destes mapas para outros metais e seus respectivos íons metálicos é pouco conhecida, limitando o diagnóstico radiológico e o estudo de doenças relacionadas com acúmulo de metais no cérebro. Propomos nesta tese avaliar a sensibilidade e a especificidade dos mapas de relaxometria (R2, R2*) e de susceptibilidade (QSM, sigla em inglês de Quantitative Susceptibility Mapping) para diferentes metais e respectivos íons paramagnéticos de encéfalos p

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24

Silva, Nivia Aparecida da. "O uso do algoritmo genético na construção de mapas de perfusão cerebral e sua aplicação em pacientes com anemia falciforme." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/59/59135/tde-27042010-092154/.

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A imagem por ressonância magnética (IRM) tem se tornado uma poderosa ferramenta clínica na avaliação da anatomia cerebral. Recentemente, várias técnicas têm tornado possível a caracterização da função cerebral através da estimativa de alguns parâmetros metabólicos. Uma dessas técnicas é a perfusão cerebral, que descreve a passagem de sangue através da rede vascular cerebral, e permite estimar, não invasivamente, algumas características das funções hemodinâmicas tais como Volume de Sangue Cerebral (CBV), Fluxo de Sangue Cerebral (CBF) e Tempo de Trânsito Médio (MTT). Neste trabalho foi desenvol

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25

Karton, Clara. "The Effect of Inbound Mass on the Dynamic Response of the Hybrid III Headform and Brain Tissue Deformation." Thesis, Université d'Ottawa / University of Ottawa, 2012. http://hdl.handle.net/10393/23576.

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The varied impact parameters that characterize an impact to the head have shown to influence the resulting type and severity of outcome injury, both in terms of the dynamic response, and the corresponding deformation of neural tissue. Therefore, when determining head injury risks through event reconstruction, it is important to understand how individual impact characteristics influence these responses. The effect of inbound mass had not yet been documented in the literature. The purpose of this study was to determine the effects of inbound mass on the dynamic impact response and brain tissue d

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26

Azzam, Sausan. "Protein Profiling Analysis of Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis Brain Tissue." Kent State University / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=kent1302472724.

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27

Ben, Abdallah Ines. "Sex dimorphism in early Alzheimer’s pathology : brain connectivity with MRI and behavioral analysis in a mouse humanized for APP and MAPT genes." Electronic Thesis or Diss., Strasbourg, 2025. http://www.theses.fr/2025STRAJ008.

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La maladie d’Alzheimer (MA) est une maladie neurodégénérative progressive, qui présente une longue phase préclinique marquée par des changements pathologiques subtils survenant avant l’apparition de symptômes. Les femmes sont plus affectées, présentant un déclin cognitif plus rapide, une plus grande atrophie de l'hippocampe et une pathologie Tau plus étendue que les hommes. Cette thèse explore le dimorphisme sexuel dans la phase préclinique de la MA en utilisant le modèle murin AppNL-F/MAPT double knock-in (dKI). Les évaluations comportementales ont révélé que les souris femelles dKI présenten

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28

Cai, Weikang. "RIT GTPASE SIGNALING MEDIATES OXIDATIVE STRESS RESISTANCE AND SURVIVAL OF ADULT NEWBORN NEURONS AFTER TRAUMATIC BRAIN INJURY." UKnowledge, 2011. http://uknowledge.uky.edu/biochem_etds/1.

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The small GTPases function as molecular switches to control diverse signaling cascades. The mammalian Rit and Rin, along with Drosophila Ric, comprise an evolutionarily conserved subfamily of the Ras-related GTPases. Previous studies using cultured cell models suggested that Rit was involved in the control of cell proliferation, transformation, neuronal differentiation, morphogenesis, and cell survival, but the principal physiological function of Rit remained uncharacterized. To address this outstanding question, we employed a genetic approach, engineering a Rit knockout mouse. Using this anim

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29

Berrueta, Razo Irma. "Molecular imaging of mouse brain tissue using Cluster Time-of-Flight Secondary Ion Mass Spectrometry." Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/molecular-imaging-of-mouse-brain-tissue-using-cluster-timeofflight-secondary-ion-mass-spectrometry(a350dc50-5337-4d32-a95c-24c617bbba97).html.

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ToF-SIMS imaging has been drawing attention due to the wide range of applications in the biological and biomedical fields. These applications include the acquisition of quantitative and qualitative data that ranges in scale from single cells to organs, image visualisation and interpretation of biomarkers for diagnosis and development of pharmaceutics. This study focused on molecular imaging of mouse brain tissue sections using cluster primary ion beams. First, cluster ion beams were applied to comparative background studies of biomolecules and brain total lipid extract. Enhancement of the seco

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Liu, Suya. "Nano-electrospray mass spectrometry for the analysis of neurosteroids and related molecules /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-486-0.

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31

Bartell, Joanna. "Bastards, Brains, Boobs and Performance: A Retrospective Account." Scholar Commons, 2010. http://scholarcommons.usf.edu/etd/3511.

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The two essays that comprise this thesis use personal narrative to discuss various aspects of illness, resistance and the body. The first essay uses performance theory to explore the social structures, mandates and restrictions concerning illness. I use the cancer experience to explore the co-creation of self, identity, and modes of being between "performer" and "audience." "Performer," in this case, is the "breast cancer patient," and the "audience" is comprised of the "social others.” The second essay explores cyborgization of the body, its painful effects, and associated social and moral va

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32

Lennmyr, Fredrik. "Signal Transduction in Focal Cerebral Ischemia : Experimental Studies on VEGF, MAPK and Src family kinases." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2002. http://publications.uu.se/theses/91-554-5267-1/.

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Combs, Carolyn C., Erin L. Hankins, Cara L. Copeland, Stacy D. Brown, and Brooks B. Pond. "Quantitative Determination of D- and L- Enantiomers of Methylphenidate in Brain Tissue by Liquid Chromatography-Mass Spectrometry." Digital Commons @ East Tennessee State University, 2013. https://doi.org/10.1002/bmc.2975.

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Methylphenidate, a psychostimulant used for the treatment of attention deficit hyperactivity disorder and narcolepsy, is administered as a 50:50 racemic mixture, despite the fact that d‐methylphenidate has been shown to have greater pharmacologic activity. This paper presents a validated LC‐MS/MS approach to separation and quantification of methylphenidate enantiomers using a vancomycin column and triethylammonium acetate to enhance the chiral separation. The method is applicable to the monitoring of these enantiomers in mouse brain, with a limit of detection of 0.5 ng/mL and a lower limit of

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García-García, Isabel, Annette Horstmann, María Angeles Jurado, et al. "Reward processing in obesity, substance addiction and non-substance addiction." Universitätsbibliothek Leipzig, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-196512.

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Similarities and differences between obesity and addiction are a prominent topic of ongoing research. We conducted an activation likelihood estimation meta-analysis on 87 studies in order to map the functional magnetic resonance imaging (fMRI) response to reward in participants with obesity, substance addiction and non-substance (or behavioural) addiction, and to identify commonalities and differences between them. Our study confirms the existence of alterations during reward processing in obesity, non-substance addiction and substance addiction. Specifically, participants with obesity or with

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Nilsson, Anna. "Molecular Profiling and Imaging of Peptides, Proteins and Drugs in Biological Tissue using Mass Spectrometry." Doctoral thesis, Uppsala universitet, Institutionen för farmaceutisk biovetenskap, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-9337.

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Biological functions within cells and organisms are mainly carried out by the translational products; proteins and peptides. The analysis and characterization of these biomolecules are of great importance for the progress in disease research and biomarker and drug discovery. The term peptidomics was introduced to describe the comprehensive analysis of peptides (e.g. neuropeptides) in biological tissues. In this thesis, a peptidomics approach using nanoflow liquid chromatography coupled to electrospray mass spectrometry (MS) has been developed for detection, identification, and quantification o

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Hansen, Enrique carlos. "Modeling non-stationary resting-state dynamics in large-scale brain models." Thesis, Aix-Marseille, 2015. http://www.theses.fr/2015AIXM4011/document.

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La complexité de la connaissance humaine est révèlée dans l'organisation spatiale et temporelle de la dynamique du cerveau. Nous pouvons connaître cette organisation grâce à l'analyse des signaux dépendant du niveau d'oxygène sanguin (BOLD), lesquels sont obtenus par l'imagerie par résonance magnétique fonctionnelle (IRMf). Nous observons des dépendances statistiques entre les régions du cerveau dans les données BOLD. Ce phénomène s' appelle connectivité fonctionnelle (CF). Des modèles computationnels sont développés pour reproduire la connectivité fonctionnelle (CF). Comme les études expérime

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早希, 吉永, and Saki Yoshinaga. "Preserved structural property after amplification of alpha-synuclein aggregates from brains of synucleinopathies." Thesis, https://doors.doshisha.ac.jp/opac/opac_link/bibid/BB13127448/?lang=0, 2020. https://doors.doshisha.ac.jp/opac/opac_link/bibid/BB13127448/?lang=0.

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神経変性疾患で蓄積する異常タンパク質の1つであるα-synは、PD、DLBおよびMSAの脳内に主に蓄積する。DLBやMSAの患者脳から解析可能な量のα-syn凝集体の増幅に成功した。増幅前後の凝集体のプロテイナーゼKコアのMS分析結果から、増幅による変化はないもののマウスとヒトのα-syn凝集体で切断パターンが異なることがわかった。これらの結果から、この方法が神経変性疾患の異常タンパク質研究の発展に貢献できることを示唆した。<br>Pathological proteins related to neurodegenerative diseases are misfolded, aggregating to form amyloid fibrils. One of the pathological proteins, α-syn, accumulates in the brains of PD, DLB and MSA. We first performed amplification of α-syn aggregates. We successfully amplified enough α-syn aggregates derived from α-syncleinopathies. We found that the MS analysis results of prote

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Muliukov, Artem. "Étude croisée des cartes auto-organisatrices et des réseaux de neurones profonds pour l'apprentissage multimodal inspiré du cerveau." Electronic Thesis or Diss., Université Côte d'Azur, 2024. https://intranet-theses.unice.fr/2024COAZ4008.

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La plasticité corticale est l'une des principales caractéristiques qui permettent à notre capacité d'apprendre et de s'adapter à notre environnement. En effet, le cortex cérébral a la capacité de s'auto-organiser à travers deux formes distinctes de plasticité: la plasticité structurelle et la plasticité synaptique. Ces mécanismes sont très probablement à la base d'une caractéristique extrêmement intéressante du développement du cerveau humain: l'association multimodale. Le cerveau utilise des corrélations spatio-temporelles entre plusieurs modalités pour structurer les données et créer du sens

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39

Williams, Anest. "Lipid profilling of polyunsaturated fatty acid - treated mouse brain and plasma. Investigation into polyunsaturated fatty acid (PUFA)-induced neuroprotection." Thesis, University of Bradford, 2010. http://hdl.handle.net/10454/4414.

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Pre-treatment with polyunsaturated fatty acids or bioactive lipid mediators has been shown to reduce neuronal injury in rodent models of focal ischaemia, but the molecular mechanisms underlying this neuroprotection are unclear. In this study, we aimed to investigate whether systemic administration of alpha linolenic acid (ALA) leads to changes in the profile of mouse brain phospholipid and bioactive lipid mediators in both mouse brain and plasma within the previously determined neuroprotection time window. Mass spectrometry (MS) and tandem mass spectrometry (MS/MS) allowed us to detect and ide

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Lerond, Julie. "Anomalies de la voie des Mitogen- Activated Protein Kinases (MAPK) : Impact sur l’oncogenèse des tumeurs cérébrales et le microenvironnement tumoral." Electronic Thesis or Diss., université Paris-Saclay, 2025. http://www.theses.fr/2025UPASL012.

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Les tumeurs cérébrales primitives de l’adulte sont des tumeurs rares en majorité malignes qui regroupent un ensemble de tumeurs très diverses comme les gliomes, les tumeurs glioneuronales et les tumeurs neuronales. Elles se distinguent par des caractéristiques histologiques et moléculaires ainsi que par leurs grades de sévérité. Des mutations de gènes activant de manière excessive la voie des MAPK (Mitogen-Activated Protein Kinase) comme celles impliquant les gènes BRAF (B-Raf proto-oncogene) ou FGFR1 (Fibroblast Growth Factor Receptor 1) sont retrouvées dans différents types de tumeurs cérébr

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García-García, Isabel, María Ángeles Jurado, Maite Garolera, et al. "Functional network centrality in obesity." Universitätsbibliothek Leipzig, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-205556.

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Obesity is associated with structural and functional alterations in brain areas that are often functionally distinct and anatomically distant. This suggests that obesity is associated with differences in functional connectivity of regions distributed across the brain. However, studies addressing whole brain functional connectivity in obesity remain scarce. Here, we compared voxel-wise degree centrality and eigenvector centrality between participants with obesity (n=20) and normal-weight controls (n=21). We analyzed resting state and task-related fMRI data acquired from the same individuals. Re

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Anyakoha, Ngozi G. "Fatty acid and lipid profiles in models of neuroinflammation and mood disorders. Application of high field NMR, gas chromotography and liquid chromotography-tandem mass spectrometry to investigate the effects of atorvaststin in brain and liver lipids and explore brain lipid changes in the FSL model of depression." Thesis, University of Bradford, 2009. http://hdl.handle.net/10454/4328.

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Lipids are important for the structural and physiological functions of neuronal cell membranes. Alterations in their lipid composition may result in membrane dysfunction and subsequent neuronal deficits that characterise various disorders. This study focused on profiling lipids of aged and LPS-treated rat brain and liver tissue with a view to explore the effect of atorvastatin in neuroinflammation, and examining lipid changes in different areas of rat brain of the Flinders Sensitive Line (FSL) rats, a genetic model of depression. Lipids and other analytes extracted from tissue samples w

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Allen, Serena, Stacy D. Brown, Carolyn Reynolds, Erin Hankins, and Brooks Pond. "Novel Liquid Chromatography – Mass Spectrometry Method for the Chiral Separation and Quantification of d- and l-threo Methylphenidate in Brain Tissue." Digital Commons @ East Tennessee State University, 2016. https://dc.etsu.edu/etsu-works/5255.

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Freund, Julia. "Emergence of individual behavioural traits and associated hippocampal plasticity in genetically identical mice." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-165013.

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Die Erforschung der Zusammenhänge zwischen Gehirnplastizität und individuellem Verhalten gestaltet sich aufgrund ihrer Komplexität im Tiermodell schwierig. Die vorliegende Studie wurde im mit dem Ziel konzipiert, die Individualitätsentwicklung bei Mäusen mit den gleichen physiologischen und genetischen Voraussetzungen in einer komplexen räumlichen und sozialen Umgebung zu beschreiben. Ich untersuchte die Korrelation dieser Entwicklung mit der Neurogenese im adulten Hippokampus als Maß für Gehirnplastizität. Zu diesem Zweck wurden zwei je mit einem automatisierten RFID-Tracking-System ausgestat

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Anyakoha, Ngozi Gloria. "Fatty acid and lipid profiles in models of neuroinflammation and mood disorders : application of high field NMR, gas chromotography and liquid chromotography-tandem mass spectrometry to investigate the effects of atorvaststin in brain and liver lipids and explore brain lipid changes in the FSL model of depression." Thesis, University of Bradford, 2009. http://hdl.handle.net/10454/4328.

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Abstract:

Lipids are important for the structural and physiological functions of neuronal cell membranes. Alterations in their lipid composition may result in membrane dysfunction and subsequent neuronal deficits that characterise various disorders. This study focused on profiling lipids of aged and LPS-treated rat brain and liver tissue with a view to explore the effect of atorvastatin in neuroinflammation, and examining lipid changes in different areas of rat brain of the Flinders Sensitive Line (FSL) rats, a genetic model of depression. Lipids and other analytes extracted from tissue samples were ana

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Ji, Fenfen. "Development of mass spectrometry-based omics for studying neurometabolic changes associated with exposure of polybrominated diphenyl ethers and its correlation with Parkinson's disease." HKBU Institutional Repository, 2019. https://repository.hkbu.edu.hk/etd_oa/650.

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We also investigated whether BDE-47 exposure could worsen PD situation by applying transgenic Drosophila (fly) model in which human α-synuclein (α-syn) was overexpressed in wide-type fly to simulate PD. BDE-47 (0, 2, 10 and 50 µM) was fed to flies continuously for 30 days. Integrated LC-MS and GC-MS profiling indicated metabolic changes in tryptophan, phenylalanine, purine, and alanine, aspartate and glutamate pathways, similar to those from mouse experiment. After quantified metabolites of interest by LC-triple quadrupole MS, we confirmed the slowed-down formation of KYNA (kynurenic acid, a n

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Green, P., Ngozi G. Anyakoha, I. Gispan-Herman, G. Yadid, and Anna Nicolaou. "Arachidonic acid-containing phosphatidylcholine species are increased in selected brain regions of a depressive animal model: implications for pathophysiology." Elsevier, 2009. http://hdl.handle.net/10454/4584.

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no<br>The Flinders Sensitive Line (FSL) rat is a genetic animal model of depression. Following recent findings that the brain fatty acid composition of FSL is characterised by increased arachidonic acid (AA), we used electrospray tandem mass spectrometry and 1H-NMR to examine lipid species in different brain areas. Cholesterol and sphingolipids were increased in the hypothalamus of the FSL rats. Furthermore, arachidonic acid-containing phosphatidylcholine species (AA-PC) were elevated with PC16:0/20:4, PC18:1/20:4 and PC18:0/20:4 (p<0.003) increased in the hypothalamus and striatum. In contra

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Towenna, C. A. "The relationship between obesity and plasminogen activator inhibitor 1 type plasma levels in patients with severe traumatic brain injury." Thesis, Sumy State University, 2016. http://essuir.sumdu.edu.ua/handle/123456789/47862.

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Plasminogen activator inhibitor 1 type (PAI-1) is the principal inhibitor of fibrinolysis. The production of PAI-1 by adipose tissue could be an important contributor to the elevated PAI-1 plasma levels. Our study was aimed to analyze the relationship between obesity and PAI-1 plasma levels in patients with severe traumatic brain injury (STBI). 214 subjects have been examined. They were grouped into two categories: 1st group contained 119 patients with STBI, 2d (control) – 95 almost healthy individuals. Patient in each group were subgrouped according to their body mass index (BMI) and waist-hi

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Pierson, Johan. "Development of Methods for Protein and Peptide Analysis Applied in Neuroscience Utilizing Mass Spectrometry." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4685.

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Mohan, Vandana. "Computer vision and machine learning methods for the analysis of brain and cardiac imagery." Diss., Georgia Institute of Technology, 2010. http://hdl.handle.net/1853/39628.

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Medical imagery is increasingly evolving towards higher resolution and throughput. The increasing volume of data and the usage of multiple and often novel imaging modalities necessitates the use of mathematical and computational techniques for quicker, more accurate and more robust analysis of medical imagery. The fields of computer vision and machine learning provide a rich set of techniques that are useful in medical image analysis, in tasks ranging from segmentation to classification and population analysis, notably by integrating the qualitative knowledge of experts in anatomy and the path

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