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Journal articles on the topic 'Brain tissue transplantation'

Author: Grafiati

Published: 4 June 2021

Last updated: 27 February 2023

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1

Woodruff, Michael L. "Transplantation of fetal brain tissue." Pavlovian Journal of Biological Science 23, no. 4 (1988): 143–57. http://dx.doi.org/10.1007/bf02700424.

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2

ITAKURA, Toru, Ekini NAKAI, Naoyuki NAKAO, and Kunio NAKAI. "Transplantation of Neural Tissue into the Brain." Neurologia medico-chirurgica 38, no. 11 (1998): 756–62. http://dx.doi.org/10.2176/nmc.38.756.

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3

Freed, W. J., and M. Poltorak. "Comments on Brain Tissue Transplantation Without Immunosuppression." Archives of Neurology 48, no. 3 (1991): 259–60. http://dx.doi.org/10.1001/archneur.1991.00530150027010.

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4

Bryukhovetskiy, Andrey S. "Translational experience of 28 years of use of the technologies of regenerative medicine to treat complex consequences of the brain and spinal cord trauma: Results, problems and conclusions." Journal of Neurorestoratology 1, no. 1 (2018): 16–31. http://dx.doi.org/10.26599/jnr.2018.9040009.

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The retrospective study summarizes 28 years of cell therapy for neurotrauma of different origin. The four experimental groups were the groups of neurotrama that included traumatic disease of the spinal cord, traumatic disease of the brain and chronic vegetative post-traumatic state. The first group received transplantations of the fetal cells of neural tissue. The second group received the tissue engineering surgery with the transplantation of the fetal cells of neural tissue. The third group were the cases of the bioengineering pasty of the damaged brain tissue; and fourth were the cases of n

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5

Freed, William J., and Thressa D. Smith. "Principles of brain tissue engineering." Behavioral and Brain Sciences 18, no. 1 (1995): 58–60. http://dx.doi.org/10.1017/s0140525x00037389.

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AbstractIt is often presumed that effects of neural tissue transplants are due to release of neurotransmitter. In many cases, however, effects attributed to transplants may be related to phenomena such as trophic effects mediated by glial cells or even tissue reactions to injury. Any conclusion regarding causation of graft effects must be based on the control groups or other comparisons used. In human clinical studies, for example, comparing the same subject before and after transplantation allows for many interpretations of the causes of clinical changes.

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6

Madrazo, Ignacio, Rebecca Franco-Bourland, Maricarmen Aguilera, et al. "Development of Human Neural Transplantation." Neurosurgery 29, no. 2 (1991): 165–77. http://dx.doi.org/10.1227/00006123-199108000-00001.

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Abstract The possibility of altering the course of Parkinson's disease by brain grafting is slowly becoming a reality through the efforts of many research groups worldwide. It has been shown that this procedure, as performed in high-level medical research centers, usually produces no permanent adverse effects and can effectively ameliorate parkinsonian signs in certain patients. This progress has served to reinforce our commitment to develop neural transplantation into an effective therapy to treat such a devastating neurodegenerative disease. We have summarized the most important events that

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7

Finger, Stanley. "A 16th century request for brain tissue transplantation." Restorative Neurology and Neuroscience 1, no. 6 (1990): 367–68. http://dx.doi.org/10.3233/rnn-1990-1601.

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8

Freed, C. R., R. E. Breeze, and N. L. Rosenberg. "Comments on Brain Tissue Transplantation Without Immunosuppression-Reply." Archives of Neurology 48, no. 3 (1991): 260–62. http://dx.doi.org/10.1001/archneur.1991.00530150027011.

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9

Azmitia, Efrain C., and Anders Bjorklund. "Cell and tissue transplantation into the adult brain." Neurobiology of Aging 8, no. 1 (1987): 77–82. http://dx.doi.org/10.1016/0197-4580(87)90062-5.

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10

Rech, Tatiana H., Daisy Crispim, Jakeline Rheinheimer, et al. "Brain Death–Induced Inflammatory Activity in Human Pancreatic Tissue." Transplantation Journal 97, no. 2 (2014): 212–19. http://dx.doi.org/10.1097/tp.0b013e3182a949fa.

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11

Гафиятуллина, Gyuzyal Gafiyatullina, Хананашвили, and Ya Khananashvili. "Neuroplasticity of Embryonic Brain Tissue in the Rats at Hemodynamic Disturbance." Journal of New Medical Technologies 22, no. 4 (2015): 54–62. http://dx.doi.org/10.12737/17025.

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The investigation was aimed to study of the local cerebral blood flow, partial pressure of oxygen (рО2) and the character of development of local vascular reactions at embryonic neurotransplant (ENT) through 4, 8 и 12 months after its transplantation into the barrel field of somatic recipient’s rat brain cortex. In experiments, a homotopical allotransplantation 17‐day embryonic nervous tissue was conducted in the Wistar rats. In microareas of embryonic neurotransplant there is an uneven distribution of local cerebral blood flow and decrease in intensity as compare

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12

Silver, Rae, and Joseph LeSauter. "Studying restoration of brain function with fetal tissue grafts: Optimal models." Behavioral and Brain Sciences 18, no. 1 (1995): 70. http://dx.doi.org/10.1017/s0140525x0003750x.

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AbstractWe concur that basic research on the use of CNS grafts is needed. Two important model systems for functional studies of grafts are ignored by Stein & Glasier. In the first, reproductive function is restored in hypogonadal mice by transplantation of GnRH-synthesizing neurons. In the second, circadian rhythmicity is restored by transplantation of the suprachiasmatic nucleus.

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13

Gubskiy, Ilya L., Daria D. Namestnikova, Veronica A. Revkova, et al. "The Impact of Cerebral Perfusion on Mesenchymal Stem Cells Distribution after Intra-Arterial Transplantation: A Quantitative MR Study." Biomedicines 10, no. 2 (2022): 353. http://dx.doi.org/10.3390/biomedicines10020353.

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Intra-arterial (IA) mesenchymal stem cells (MSCs) transplantation providing targeted cell delivery to brain tissue is a promising approach to the treatment of neurological disorders, including stroke. Factors determining cell distribution after IA administration have not been fully elucidated. Their decoding may contribute to the improvement of a transplantation technique and facilitate translation of stroke cell therapy into clinical practice. The goal of this work was to quantitatively assess the impact of brain tissue perfusion on the distribution of IA transplanted MSCs in rat brains. We p

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14

Richardson, R. Mark, Helen L. Fillmore, Kathryn L. Holloway, and William C. Broaddus. "Progress in cerebral transplantation of expanded neuronal stem cells." Journal of Neurosurgery 100, no. 4 (2004): 659–71. http://dx.doi.org/10.3171/jns.2004.100.4.0659.

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Object. Given the success and limitations of human fetal primary neural tissue transplantation, neuronal stem cells (NSCs) that can be adequately expanded in culture have been the focus of numerous attempts to develop a superior source of replacement cells for restorative neurosurgery. To clarify recent progress toward this goal, the transplantation into the adult brain of NSCs, expanded in vitro before grafting, was reviewed. Methods. Neuronal stem cells can be expanded from a variety of sources, including embryos, fetuses, adult bone marrow, and adult brain tissue. Recent investigations of e

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15

Zhong, Jin, Albert Chan, Leeron Morad, Harley I. Kornblum, Guoping Fan, and S. Thomas Carmichael. "Hydrogel Matrix to Support Stem Cell Survival After Brain Transplantation in Stroke." Neurorehabilitation and Neural Repair 24, no. 7 (2010): 636–44. http://dx.doi.org/10.1177/1545968310361958.

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Stroke is a leading cause of adult disability. Stem/progenitor cell transplantation improves recovery after stroke in rodent models. These studies have 2 main limitations to clinical translation. First, most of the cells in stem/progenitor transplants die after brain transplantation. Second, intraparenchymal approaches target transplants to normal brain adjacent to the stroke, which is the site of the most extensive natural recovery in humans. Transplantation may damage this tissue. The stroke cavity provides an ideal target for transplantation because it is a compartmentalized region of necro

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16

CRAIN, STANLEY M. "CNS Tissue Culture Analyses of Trophic Mechanisms in Brain Transplantation." Annals of the New York Academy of Sciences 495, no. 1 Cell and Tiss (1987): 103–7. http://dx.doi.org/10.1111/j.1749-6632.1987.tb23669.x.

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17

Kolařík, J., P. Nádvorník, K. Tabarka, and M. Dvořák. "Transplantation of human embryonic nerve tissue into a schizophrenic's brain." International Journal of Psychophysiology 7, no. 2-4 (1989): 262–63. http://dx.doi.org/10.1016/0167-8760(89)90202-x.

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18

Lewis, David D., Robin R. Vidovich, and LifeBanc Cleveland. "Factors Influencing Organ Placement Efforts in Donors with Brain Tumors." Journal of Transplant Coordination 6, no. 1 (1996): 37–38. http://dx.doi.org/10.1177/090591999600600110.

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A 3-year retrospective review of brain tumor cases was performed to determine factors that influence organ procurement in light of the increase in references in transplant literature to the hazards of transplanting organs from donors with brain tumors. A 3-year review of cases in which organ procurement efforts occurred were evaluated. Of 314 cases resulting from this review, organ procurement efforts yielded 10 patients with a diagnosis of brain tumor. Of those 10 cases, seven progressed to organ donation, with at least one organ per patient recovered. Manipulation of brain tumors or manipula

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19

Hoeven, Joost A. B. van der, Paul de Vos, Ingrid Molema, Gert J. Ter Horst, and Rutger J. Ploeg. "BRAIN DEATH INDUCES TISSUE ACTIVATION AND APOPTOSIS IN CADAVERIC DONOR LIVERS." Transplantation 69, Supplement (2000): S198. http://dx.doi.org/10.1097/00007890-200004271-00326.

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20

Saito, Y., M. Goto, K. Maya, et al. "THE INFLUENCE OF BRAIN DEATH ON TISSUE FACTOR EXPRESSION IN THE PANCREATIC TISSUE AND ISOLATED ISLETS IN RATS." Transplantation 86, Supplement (2008): 565. http://dx.doi.org/10.1097/01.tp.0000331042.84685.74.

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21

Granholm, Ann-Charlotte E., Maria Curtis, David M. Diamond, Berrilyn J. Branch, Karen L. Heman, and Gregory M. Rose. "Development of an Intact Blood-Brain Barrier in Brain Tissue Transplants is Dependent on the Site of Transplantation." Cell Transplantation 5, no. 2 (1996): 305–14. http://dx.doi.org/10.1177/096368979600500219.

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Transplantation of fetal septal forebrain tissue was performed to the anterior chamber of the eye, or intracranially to the rostral hippocampal formation in rats, to evaluate the impact of transplantation site on the development of an intact blood–brain barrier (BBB). The tissue was studied at 1, 2, 3, and 4 wk following transplantation by means of intravenous injection of Trypan blue, which is a vital stain not normally penetrating the BBB, as well as with an antibody specifically directed against the rat BBB, SMI71. In the intraocular septal transplants, there was a significant leakage of Tr

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22

Hu, Renlin, Yaming Hao, Fan Tao, Feng Wang, Weichen Zhang, and Yuxuan Tao. "Transplantation of Bone Marrow Mesenchymal Stem Cells (BMSCs) Improves Nerve Cell Function in Rats with Cerebral Infarction and Injury." Journal of Biomaterials and Tissue Engineering 12, no. 11 (2022): 2254–59. http://dx.doi.org/10.1166/jbt.2022.3182.

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Our study intends to assess the effect of transplantation of bone marrow mesenchymal stem cells (BMSCs) on nerve cell in rats with cerebral infarction and injury. 36 healthy rats were separated into JS group (sham-operation), NG group (cerebral infarction) and YZ group (BMSCs transplantation). The arrangement of brain tissue in JS group was integrated without edema and confused in NG group with obvious edema. However, the necrosis degree of brain tissue in YZ group was alleviated. There were symptoms of muscle loss in the right foreleg and hind leg of rats in NG group. The NSS score in NG grou

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23

McCarter, J. F., A. L. McGregor, P. A. Jones, and J. Sharkey. "FK 506 protects brain tissue in animal models of stroke." Transplantation Proceedings 33, no. 3 (2001): 2390–92. http://dx.doi.org/10.1016/s0041-1345(01)02033-4.

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24

Backlund, Erik-Olof, Per-Ola Granberg, Bertil Hamberger, et al. "Transplantation of adrenal medullary tissue to striatum in parkinsonism." Journal of Neurosurgery 62, no. 2 (1985): 169–73. http://dx.doi.org/10.3171/jns.1985.62.2.0169.

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✓ Autologous adrenal medullary tissue was transplanted to the striatum in two patients with severe parkinsonism. The aim was to provide the striatum with a new cellular source of catecholamines. Some rewarding effects were registered. This is the first time that such tissue has been transplanted in the human brain. The results merit further clinical trials.

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25

Cunningham, Janet, Yoshitsugu Oiwa, Dea Nagy, Greg Podsakoff, Peter Colosi, and Krys S. Bankiewicz. "Distribution of AAV-TK following Intracranial Convection-Enhanced Delivery into Rats." Cell Transplantation 9, no. 5 (2000): 585–94. http://dx.doi.org/10.1177/096368970000900504.

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Adeno-associated virus (AAV)-based vectors are being tested in animal models as viable treatments for glioma and neurodegenerative disease and could potentially be employed to target a variety of central nervous system disorders. The relationship between dose of injected vector and its resulting distribution in brain tissue has not been previously reported nor has the most efficient method of delivery been determined. Here we report that convection-enhanced delivery (CED) of 2.5 × 108, 2.5 × 109, or 2.5 × 1010 particles of AAV-thymidine kinase (AAV-TK) into rat brain revealed a clear dose resp

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26

Gustavii, Bjorn. "FETAL BRAIN TRANSPLANTATION FOR PARKINSON'S DISEASE: TECHNIQUE FOR OBTAINING DONOR TISSUE." Lancet 333, no. 8637 (1989): 565. http://dx.doi.org/10.1016/s0140-6736(89)90114-1.

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27

Jensen, Steen, Torben Sørensen, and Jens Zimmer. "Cryopreservation of fetal rat brain tissue later used for intracerebral transplantation." Cryobiology 24, no. 2 (1987): 120–34. http://dx.doi.org/10.1016/0011-2240(87)90014-9.

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28

Lushchekina, E. A., M. B. Kurbatova, N. M. Khonicheva, and V. P. Podachin. "Transplantation of embryonal amygdalar tissue into the brain of amygdalectomized rats." Neuroscience and Behavioral Physiology 19, no. 4 (1989): 310–13. http://dx.doi.org/10.1007/bf01236019.

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29

Malyshev, I. I. "Repair processes in nerve tissue after brain transplantation in young rabbits." Bulletin of Experimental Biology and Medicine 105, no. 5 (1988): 718–20. http://dx.doi.org/10.1007/bf00841544.

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30

Bistrian, Roxana, Hans Martin, Erhard Seifried, Albrecht Mueller, and Reinhard Henschler. "Multi-Tissue Homing of Repopulating Hematopoietic Cells after Bone Marrow Transplantation in Mice." Blood 106, no. 11 (2005): 5232. http://dx.doi.org/10.1182/blood.v106.11.5232.5232.

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Abstract We wished to assess the tissue distribution of repopulating hematopoietic stem cells after bone marrow transplantation (BMT), since so far only sub-fractions of repopulating cells have been found to home to hematopoietic organs and tissues in BMT models. Two x 105 lineage depleted (lin−) bone marrow cells from C57BL/6 Ly5.1 mice were transplanted into 2 x 5.5 Gy irradiated Ly5.2 congenic C57BL/6 recipient mice. On day 1, 7 or 28 post BMT, cell suspensions were prepared from bone marrow, spleen, muscle, brain, lung and liver, and CD45+ cells were enriched by magnetic beads separation.

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31

Ağasəlim qızı Abdullayeva, Fidan. "ORQAN BANKININ YARADILMASININ ƏHƏMİYYƏTİ." SCIENTIFIC WORK 53, no. 04 (2020): 44–47. http://dx.doi.org/10.36719/aem/2007-2020/53/44-47.

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32

Palaoglu, Selçuk, Kemal Benli, Necmettin Pamir, Türkan Erbengi, and Aykut Erbengi. "Examination of autologous and embryonic cortical brain tissue transplantation to adult brain cortex in rats." Surgical Neurology 29, no. 3 (1988): 183–90. http://dx.doi.org/10.1016/0090-3019(88)90003-1.

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33

Nijboer, W. N., T. A. Schuurs, J. A. B. van der Hoeven, et al. "EFFECT OF BRAIN DEATH ON GENE EXPRESSION AND TISSUE ACTIVATION IN DONOR KIDNEYS." Transplantation 78 (July 2004): 18. http://dx.doi.org/10.1097/00007890-200407271-00060.

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34

Gray, Jeffrey A., Helen Hodges, and John Sinden. "Prospects for the clinical application of neural transplantation with the use of conditionally immortalized neuroepithelial stem cells." Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences 354, no. 1388 (1999): 1407–21. http://dx.doi.org/10.1098/rstb.1999.0488.

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Although neural transplantation has made a relatively successful transition from the animal laboratory to human neurosurgery for the treatment of Parkinson's disease, the use of human embryonic brain tissue as the source of transplants raises difficult ethical and practical problems. These are likely to impede the widespread use of this otherwise promising therapy across the range of types of brain damage to which the results of animal experiments suggest its potential applicability. Various alternative approaches are reviewed briefly, aimed at developing sources of tissue for transplantation

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35

Blennow, Ola, Erik Eliasson, Tommy Pettersson, et al. "Posaconazole Concentrations in Human Tissues after Allogeneic Stem Cell Transplantation." Antimicrobial Agents and Chemotherapy 58, no. 8 (2014): 4941–43. http://dx.doi.org/10.1128/aac.03252-14.

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ABSTRACTFew data have been published regarding posaconazole tissue concentrations in humans. We analyzed tissue concentrations in biopsy specimens taken at autopsy from seven patients who received posaconazole prophylaxis because of graft-versus-host disease. The results were compared to plasma concentrations collected before death. Tissue concentrations suggestive of an accumulation of posaconazole were found in the heart, lung, liver, and kidney but not in the brain.

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36

Mendez, Ivar, Murray Hong, Stephen Smith, Alain Dagher, and Jacques Desrosiers. "A neural transplantation cannula and microinjector system: experimental and clinical experience." Neurosurgical Focus 7, no. 3 (1999): E4. http://dx.doi.org/10.3171/foc.1999.7.3.5.

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The authors present a simple, reliable, and safe system for performing neural transplantation in the human brain. The device consists of a transplantation cannula and microinjector system that has been specifically designed to reduce implantation-related trauma and to maximize the number of graft deposits for each injection. The system was evaluated first in an experimental rat model of Parkinson's disease (PD). Animal transplantation with this system showed excellent graft survival with minimal trauma to the brain. Following this experimental stage, the cannula and microinjector system was us

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37

Mendez, Ivar, Murray Hong, Stephen Smith, Alain Dagher, and Jacques Desrosiers. "Neural transplantation cannula and microinjector system: experimental and clinical experience." Journal of Neurosurgery 92, no. 3 (2000): 493–99. http://dx.doi.org/10.3171/jns.2000.92.3.0493.

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✓ The authors present a simple, reliable, and safe system for performing neural transplantation in the human brain. The device consists of a transplantation cannula and microinjector system that has been specifically designed to reduce implantation-related trauma and to maximize the number of graft deposits per injection. The system was evaluated first in an experimental rat model of Parkinson's disease (PD). Animals in which transplantation with this system had been performed showed excellent graft survival with minimal trauma to the brain. Following this experimental stage, the cannula and m

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38

Plekhova, N. G., I. V. Radkov, S. V. Zinoviev, and V. B. Shumatov. "Structural and functional transformations of the brain in experimental mild traumatic brain injury." Genes & Cells 17, no. 1 (2022): 26–30. http://dx.doi.org/10.23868/202205005.

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In mild traumatic brain injury, it is of interest to study neurode-generative conditions resulting from inflammatory changes in the nervous tissue. Purpose of the study: in the acute period in case of mild experimental traumatic brain injury, to reveal structural transformations of the nervous tissue of the brain. A modified model of a falling weight was used to reproduce of these trauma in adult rats. An immunohistochemical study of the brain with using rat-specific monoclonal antibodies to endothelin-1, glial fibrillar acidic protein, vimentin, and blood-brain barrier endothelial protein (SM

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39

Zheng, Jin, Xueyu Mao, Delong Wang, and Shiliang Xia. "Preconditioned MSCs Alleviate Cerebral Ischemia-Reperfusion Injury in Rats by Improving the Neurological Function and the Inhibition of Apoptosis." Brain Sciences 12, no. 5 (2022): 631. http://dx.doi.org/10.3390/brainsci12050631.

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Mesenchymal stem cells (MSCs) have great application prospects in the treatment of ischemic injury. However, their long-time cultivation before transplantation and poor survival after transplantation greatly limit the therapeutic effect and applications. This study aimed to investigate whether MSCs under the ischemic microenvironment could improve their survival and better alleviate cerebral ischemic injury. Firstly, we used ischemic brain tissue to culture MSCs and evaluated the functional changes of MSCs. Then a middle cerebral artery occlusion (MCAO) model was induced in rats, and the pretr

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40

Saito, Y., M. Goto, K. Maya, et al. "The Influence of Brain Death on Tissue Factor Expression in the Pancreatic Tissues and Isolated Islets in Rats." Transplantation Proceedings 41, no. 1 (2009): 307–10. http://dx.doi.org/10.1016/j.transproceed.2008.10.080.

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41

Perez-Bouza, Alberto, Stefano Di Santo, Stefanie Seiler, et al. "Simultaneous Transplantation of Fetal Ventral Mesencephalic Tissue and Encapsulated Genetically Modified Cells Releasing GDNF in a Hemi-Parkinsonian Rat Model of Parkinson’s Disease." Cell Transplantation 26, no. 9 (2017): 1572–81. http://dx.doi.org/10.1177/0963689717721202.

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Transplantation of fetal ventral mesencephalic (VM) neurons for Parkinson’s disease (PD) is limited by poor survival and suboptimal integration of grafted tissue into the host brain. In a 6-hydroxydopamine rat model of PD, we investigated the feasibility of simultaneous transplantation of rat fetal VM tissue and polymer-encapsulated C2C12 myoblasts genetically modified to produce glial cell line–derived neurotrophic factor (GDNF) or mock-transfected myoblasts on graft function. Amphetamine-induced rotations were assessed prior to transplantation and 2, 4, 6 and 9 wk posttransplantation. We fou

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42

Sonmez, Yusuf Ercin. "Future of Solid Organ Transplantation: Organ-Specific Tolerance." KIDNEYS 10, no. 3 (2021): 130–36. http://dx.doi.org/10.22141/2307-1257.10.3.2021.239589.

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A transplant between two people who are not genetically identical is called an allotransplant and the process is called allotransplantation. Donor organs and tissues can be from people who are living, or people who have died because of a significant brain injury or lack of circulation. Allotransplantation can create a rejection process where the immune system of the recipient attacks the foreign donor organ or tissue and destroys it. The recipient may need to take immunosuppressive medication for the rest of their life to reduce the risk of rejection of the donated organ. In general, deliberat

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43

Nijboer, Willemijn N., Theo A. Schuurs, Joost A. B. van der Hoeven, et al. "Effect of Brain Death on Gene Expression and Tissue Activation in Human Donor Kidneys." Transplantation 78, no. 7 (2004): 978–86. http://dx.doi.org/10.1097/01.tp.0000135565.49535.60.

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44

Su, Tao, Raffaella Scardigli, Luisa Fasulo, et al. "Bystander Effect on Brain Tissue of Mesoangioblasts Producing Neurotrophins." Cell Transplantation 21, no. 8 (2012): 1613–27. http://dx.doi.org/10.3727/096368912x640475.

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45

Loseva, E. V., V. I. Tsymbalyuk, L. D. Pichkur, and A. G. Bragin. "Effect of embryonic brain tissue transplantation on structural changes in the rat brain after craniocerebral trauma." Neurophysiology 27, no. 5-6 (1997): 276–84. http://dx.doi.org/10.1007/bf01081905.

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46

Chiang, Yung-Hsiao, Shinn-Zong Lin, Cesario V. Borlongan, Barry J. Hoffer, Marisela Morales, and Yun Wang. "Transplantation of Fetal Kidney Tissue Reduces Cerebral Infarction Induced by Middle Cerebral Artery Ligation." Journal of Cerebral Blood Flow & Metabolism 19, no. 12 (1999): 1329–35. http://dx.doi.org/10.1097/00004647-199912000-00006.

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The authors, and others, have recently reported that intracerebral administration of glial cell line-derived neurotrophic factor (GDNF) or osteogenic protein-1 protects against ischemia-induced injury in the cerebral cortex of adult rats. Because these trophic factors are highly expressed in the fetal, but not adult, kidney cortex, the possibility that transplantation of fetal kidney tissue could serve as a cellular reservoir for such molecules and protect against ischemic injury in cerebral cortex was examined. Fetal kidneys obtained from rat embryos at gestational day 16, and adult kidney co

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47

Woerly, S., K. Ulbrich, V. Chytrý, et al. "Synthetic Polymer Matrices for Neural Cell Transplantation." Cell Transplantation 2, no. 3 (1993): 229–39. http://dx.doi.org/10.1177/096368979300200307.

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This study proposes a strategy to promote the integration of a neural graft into the host brain tissue. It involves the attachment of donor cells to a polymeric matrix, and the implantation of this cell-polymer matrix. We have synthesized hydrogels based on N-(2-hydroxypropyl)-methacrylamide (HPMA) to produce highly porous matrices. As preliminary steps, we have examined: 1) The response of the brain tissue to the implantation of PHPMA/collagen hydrogels; 2) adhesion, growth, differentiation, and viability of embryonic neuronal cells, and embryonal carcinoma-derived neurons seeded onto PHPMA s

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48

Jiao, Qian, Li Wang, Zhichao Zhang, Xinlin Chen, Haixia Lu, and Yong Liu. "The Biological Behaviors of Neural Stem Cell Affected by Microenvironment from Host Organotypic Brain Slices under Different Conditions." International Journal of Molecular Sciences 24, no. 4 (2023): 4182. http://dx.doi.org/10.3390/ijms24044182.

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Therapeutic strategies based on neural stem cells (NSCs) transplantation bring new hope for neural degenerative disorders, while the biological behaviors of NSCs after being grafted that were affected by the host tissue are still largely unknown. In this study, we engrafted NSCs that were isolated from a rat embryonic cerebral cortex onto organotypic brain slices to examine the interaction between grafts and the host tissue both in normal and pathological conditions, including oxygen–glucose deprivation (OGD) and traumatic injury. Our data showed that the survival and differentiation of NSCs w

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d’Errico, Paolo, Stephanie Ziegler-Waldkirch, Vanessa Aires та ін. "Microglia contribute to the propagation of Aβ into unaffected brain tissue". Nature Neuroscience 25, № 1 (2021): 20–25. http://dx.doi.org/10.1038/s41593-021-00951-0.

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Abstract:

AbstractMicroglia appear activated in the vicinity of amyloid beta (Aβ) plaques, but whether microglia contribute to Aβ propagation into unaffected brain regions remains unknown. Using transplantation of wild-type (WT) neurons, we show that Aβ enters WT grafts, and that this is accompanied by microglia infiltration. Manipulation of microglia function reduced Aβ deposition within grafts. Furthermore, in vivo imaging identified microglia as carriers of Aβ pathology in previously unaffected tissue. Our data thus argue for a hitherto unexplored mechanism of Aβ propagation.

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Moraes, Edvaldo Leal de, and Maria Cristina Komatsu Braga Massarollo. "Family refusal to donate organs and tissue for transplantation." Revista Latino-Americana de Enfermagem 16, no. 3 (2008): 458–64. http://dx.doi.org/10.1590/s0104-11692008000300020.

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Abstract:

This study aimed to discover how potential eligible donor families perceive the decision-making process to refuse organ and tissue donation for transplantation. A qualitative research was performed in order to understand the families' perception, based on the situated-phenomenon structure. Eight family members were interviewed, with four themes and fourteen subthemes emerging from the analysis of the statements. The propositions that emerged from the study indicated that the essence of the phenomenon was manifested as a shocking or despairing situation, experienced through the hospitalization

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