Relevant bibliographies by topics / Break Through Responders

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Academic literature on the topic 'Break Through Responders'

Author: Grafiati
Published: 3 June 2025
Last updated: 31 July 2025

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Journal articles on the topic "Break Through Responders"

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Sunil, dat Maheshwari1 Hafiz Wajid Ali Buriro2 Samiullah Shaikh1 Bikharam Devrajani1. "FACTORS REFRACTORY TO CONVENTIONAL INTERFERON BASED THERAPY IN CHRONIC HEPATITIS C." INDO AMERICAN JOURNAL OF PHARMACEUTICAL RESEARCH 07, no. 01 (2017): 7426–32. https://doi.org/10.5281/zenodo.1006961.

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OBJECTIVE: To determine the factors in patients suffering from chronic HCV, refractory to conventional interferon therapy. MATERIAL & METHODS: This descriptive case series study was conducted at Out Patient’s Department of Hepatitis Control Program at Medical Unit IV, LUMHS Hospital Jamshoro from June2013 to December 2013. Based on Inclusion and Exclusion criteria, a total of Eighty (80) patients with the established diagnosis of chronic Hepatitis ‘C’ were recruited by Non-probability consecutive sampling technique after obtaining a well informed and written consent. Socio-demographic data
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Ramachandiran, Sampath, Jean L. Koff, Laurent Garderet, et al. "Detection of NFKB2 3’end Loos By Quantitative PCR (QPCR) or Detection of NFKB2 Rearrangements Correlate with Bortezomib Response in Multiple Myeloma." Blood 124, no. 21 (2014): 2138. http://dx.doi.org/10.1182/blood.v124.21.2138.2138.

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Abstract Background: Multiple myeloma is a malignant plasma cell cancer that is increasing in frequency in today’s aging population. While proteasome inhibitors such as bortezomib have improved the outcome of treatment, many patients fail to achieve a complete remission and ultimately the disease progresses. With these new treatments come higher associated toxicities and significant healthcare costs for the drugs. Several new cancer therapies with companion diagnostics have been approved in parallel with the drug to guide physicians in selecting those patients who would specifically benefit fr
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Hashemi, C. A. Braun, Y. CQ Zang, J. A. Arbona, et al. "Serum immunologic markers in multiple sclerosis patients on continuous combined therapy with beta-interferon 1a, prednisone and azathioprine." Multiple Sclerosis Journal 12, no. 5 (2006): 652–58. http://dx.doi.org/10.1177/1352458506070665.

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Break-through symptoms (BTS) in multiple sclerosis (MS) patients on beta-interferon (beta-IFN) monotherapy are most frequently treated with a brief administration of steroids. Here, we report the results of monitoring serum immunologic markers recorded at three-month intervals for 1.5 years in responders to beta-INF 1a (Avonex) monotherapy ( n = 21) and MS patients placed on Avonex with prednisone ( n = 83) and Avonex, prednisone and azathioprine (AZA) ( n = 21) because of BTS. Compared to 23 healthy controls, patients on Avonex monotherapy and Avonex with prednisone, in individuals on Avonex,
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Pacheco-Barcia, Vilma, Andrés Muñoz, Elena Castro, et al. "The Homologous Recombination Deficiency Scar in Advanced Cancer: Agnostic Targeting of Damaged DNA Repair." Cancers 14, no. 12 (2022): 2950. http://dx.doi.org/10.3390/cancers14122950.

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BRCA1 and BRCA2 are the most recognized tumor-suppressor genes involved in double-strand DNA break repair through the homologous recombination (HR) system. Widely known for its role in hereditary cancer, HR deficiency (HRD) has turned out to be critical beyond breast and ovarian cancer: for prostate and pancreatic cancer also. The relevance for the identification of these patients exceeds diagnostic purposes, since results published from clinical trials with poly-ADP ribose polymerase (PARP) inhibitors (PARPi) have shown how this type of targeted therapy can modify the long-term evolution of p
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Paradkar, Sateja, Annie Cui, Julia Purcell, Sam Friedman, Ryan Jensen, and Ranjit Bindra. "Abstract B051: PARG inhibition leads to the formation of toxic nuclear PARP1 aggregates." Molecular Cancer Therapeutics 22, no. 12_Supplement (2023): B051. http://dx.doi.org/10.1158/1535-7163.targ-23-b051.

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Abstract Mutations in DNA repair genes, such as BRCA1/2 mutations, occur in 50-70% of breast cancers among others. PARP inhibitors (PARPis) have shown remarkable efficacy against these tumors, however, emerging clinical evidence has revealed that PARPi resistance represents a major concern in these cancers with up to 90% of initial responders eventually developing resistance to the therapy. To overcome the limitations of PARPis, researchers have been working towards developing PARG inhibitors (PARGis) for the treatment of DNA repair-deficient cancers. In response to DNA damage, PARP1 synthesiz
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Zahoor, Sarmad, Samreen Hameed, Saroosh Zahoor, et al. "Efficacy of sofosbuvir in the treatment-naïve patients infected with 3a genotype of Hepatitis C." Professional Medical Journal 28, no. 01 (2021): 72–79. http://dx.doi.org/10.29309/tpmj/2021.28.01.4610.

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Objectives: This study was conducted to test the efficacy of Sofosbuvir in patients of genotype 3a who are treatment-naïve which represents the most common setting in Pakistan. Study Design: Experimental study. Setting: Mayo Hospital, Lahore, Punjab, Pakistan. Period: August 2016 to September 2017. Material & Methods: We used an Open label and Quasi Experimental Study Design to test the efficacy of Sofosbuvir in 262 treatment-naïve patients. The duration of the therapy was 24 weeks. All patients were treated with Sofosbuvir 400mg once daily and Ribavirin 400 mg thrice daily. The end of tre
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Pietrantonio, Filippo, Anna Tessari, Rosalba Miceli, et al. "Gain of ALK gene copy number to predict lack of response to anti-EGFR treatment in advanced chemorefractory colorectal cancer (CRC) with KRAS/NRAS/BRAF/PI3KCA wild-type status." Journal of Clinical Oncology 31, no. 15_suppl (2013): 3641. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.3641.

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3641 Background: KRAS, BRAF, NRAS and exon 20 PIK3CA quadruple wild-type CRC is associated with 41.2% response rate to anti-EGFR treatments. Even in molecular characterized patients, there is still a subset of non responders. The identification of additional predictive biomarkers is an unmet clinical need for treatment personalization. Alterations of ALK oncoprotein may interfere with the biological activity of EGFR through cross-talk of downstream signalling pathways. Methods: This retrospective analysis aimed to investigate the correlation between ALK gene copy number (GCN), assessed by fluo
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Agarwal, Utkarsh, Bharti Shukla, and Sudhir Singh. "ASSESSING GLASS CEILING AND GENDER INEQUALITY FOR WOMEN EMPLOYEE IN SERVICE SECTOR." Sachetas 2, no. 2 (2023): 58–66. http://dx.doi.org/10.55955/220006.

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The glass ceiling is a barrier to the advancement of capable female professionals in the workplace, primarily due to gender or racism (Abidin, Z. Z. 2009). Carol Hymowitz and Timothy Schellhardt of the Wall Street Journal developed the term "glass ceiling" in 1986. Many researchers like (Shukla, 2015) have confirmed the presence of a glass ceiling based on various constructs such as social, cultural, and individual constraints. In India, there is no substantial proof on this topic. In their workplaces, the majority of the respondents had experienced some form of prejudice. Despite increases in
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Gkotzamanidou, Maria, Evangelos Terpos, Nikhil C. Munshi, Vassilis L. Souliotis, and Meletios A. Dimopoulos. "The Simultaneous Accumulation of the Extremely Cytotoxic Interstrand Cross-Links and Double-Strand Breaks Contributes to the Successful Anti-Myeloma Therapy; The Effect of DNA Repair Inhibitors." Blood 126, no. 23 (2015): 4177. http://dx.doi.org/10.1182/blood.v126.23.4177.4177.

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Abstract Several anticancer drugs exert their antitumor effects through the production of DNA interstrand cross-links (ICLs). During ICL repair, replication forks stall at the ICL, inducing the formation of a lethal form of DNA damage, termed DNA double-strand breaks (DSBs), which are repaired mainly by homologous recombination (HR) and non-homologous end joining (NHEJ). Herein, using the ICL-inducing drug melphalan, we investigated the underlying mechanisms in processing and repair of pharmaceutical induced DNA damage and their contribution to the successful outcome of melphalan therapy. We s
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Ahmed, Arooj, Mark Orland, Praveena Thiagarajan, et al. "A Real-Life Experience of Iptacopan in Paroxysmal Nocturnal Hemoglobinuria." Blood 144, Supplement 1 (2024): 5695. https://doi.org/10.1182/blood-2024-211788.

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The availability of complement inhibitors has dramatically changed the management of PNH. The longest experience exists with C5 inhibitors. Introduction of C3 blockade allowed also to overcome extravascular hemolysis in patients with break through hemolysis. Parenteral treatment options like complement protein C5 and C3 inhibitors, thus, became the mainstay therapeutic options in PNH. Recently, the PNH therapeutic armamentarium has been expanded by the FDA approval of an oral factor B blocker, iptacopan administered as single agent to effectively control hemolysis in PNH. Obviously, there are
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Books on the topic "Break Through Responders"

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Wigginton, Russell T. The Strange Career of the Black Athlete. Greenwood Publishing Group, Inc., 2006. http://dx.doi.org/10.5040/9798216019503.

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Few realize that some sports were integrated, or even dominated by blacks, before becoming dominated by whites, for example, horse racing, golf, hockey, and tennis. This book provides a lens through which to view the historical context and specific circumstances of African Americans' presence in various sports. The author asks why sport has at times challenged the status quo with regard to race and civil rights, and at other times reinforced it. To that end, he analyzes various sports and asks why and when has each sport responded differently. Wigginton asks how did blacks break the color barr
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Book chapters on the topic "Break Through Responders"

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Panarello, Demetrio, and Gennaro Punzo. "The impact of economic insecurity on life satisfaction among German citizens." In Proceedings e report. Firenze University Press and Genova University Press, 2023. http://dx.doi.org/10.36253/979-12-215-0106-3.11.

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The concept of life satisfaction dates back to the Age of Enlightenment and became popular in the Nineteenth century as a synonym for ‘good life’. Efforts are still underway to overcome the traditional economic criteria of well-being by broadening the definition and measurement of life satisfaction based on a large set of indicators. Although ‘money cannot buy happiness’, the economic dimension remains a crucial element of life satisfaction. Economic insecurity arises from unpredictable economic losses, which may affect individuals’ well-being due to the feeling of failure and inability to rec
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Dubler, Joshua, and Vincent W. Lloyd. "The Limits of Reformist Religion." In Break Every Yoke. Oxford University Press, 2020. http://dx.doi.org/10.1093/oso/9780190949150.003.0004.

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How have American religious communities responded to the rapid growth of the prison? With ambivalence—as we show through case studies of Protestant responses. Protestant institutions consistently spoke out against the growing prison system, charging that it runs against a Christian sense of justice. But, from the 1960s, liberal Protestant elites no longer had the public’s ear. Evangelicals, led by Charles Colson, also spoke out about the prison system from the perspective of biblical justice, but their methods of engagement were too easily incorporated into the prison state. At the margins, me
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Dallek, Robert. "Muddling Through." In Franklin D. Roosevelt and American Foreign Policy, 1932-1945. Oxford University PressNew York, NY, 1995. http://dx.doi.org/10.1093/oso/9780195097320.003.0006.

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Abstract IN THE THREE MONTHS after the Senate rejected membership in the World Court, events abroad fanned American fears of war. In February 1935, Mussolini responded to a two-month-old border dispute with Ethiopia by sending additional forces to Italian East Africa. In March, Berlin openly repudiated the disarmament clauses of the Versailles Treaty by revealing the existence of a German air force and plans to build a 550,000-man army. In response, France doubled the existing period of service for conscripts, and the League voted to consider economic and financial measures against any state e
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Bhagwat, Dr Prasanna M. "EVALUATING ADDITIVE MANUFACTURING OPTIONS THROUGH TOPSIS METHOD: A COMPREHENSIVE DECISION-MAKING APPROACH." In Futuristic Trends in Mechanical Engineering Volume 3 Book 4. Iterative International Publishers, Selfypage Developers Pvt Ltd, 2024. http://dx.doi.org/10.58532/v3bkme4p1ch3.

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In the current competitive landscape, various industries are actively seeking intelligent technologies to maintain competitiveness. These technologies assist research and development teams in clearly expressing ideas and swiftly introducing products to the market while minimizing production timelines and costs. Every additive manufacturing (AM) machine possesses distinct strengths in product fabrication, material utilization, and waste reduction. Key factors such as the costs of machinery and materials hold significant importance and greatly influence the assessment of prototype expenses. The
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Feaver, Peter D. "Politics, Politicization, and Public Confidence." In Thanks for Your Service. Oxford University PressNew York, 2023. http://dx.doi.org/10.1093/oso/9780197681121.003.0006.

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Abstract The public does not yet see the military as a hyperpartisan organization, but there are indications that many partisans would be willing to encourage the military to assume a more partisan role—as long as it remains on their side. A majority of the public believes that members of the military affiliate with a party, and the plurality view is that those affiliations are evenly divided between Republican and Democrats. Respondents are slightly more likely to believe the military aligns with their own party. Only about one-quarter of the public believes the military is too partisan, but
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Stolar Alexander. "Live CBRN Agent Training for Responders as a Key Role in a Safe Crisis Recovery." In NATO Science for Peace and Security Series - E: Human and Societal Dynamics. IOS Press, 2012. https://doi.org/10.3233/978-1-61499-039-0-58.

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Responders on CBRN incidents have a difficult task because they must tackle incidents effectively to avert a disaster. A malfunction of these teams can easily cause them to waver and can precipitate a full intervention. In order to prevent this, the staff goes through large-scale training which covers a wide variety of practice scenarios. Although the physical demands can be practiced in training very well, the mental aspects are often neglected. It is possible to use simulations or films and past experiences in the training, or to build at least a stress situation even if it will not come clo
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Djurić Milovanović, Aleksandra, and Marko Veković. "State, Religion and Refugees in Serbia." In Religion and Forced Displacement in Eastern Europe, the Caucasus, and Central Asia. Amsterdam University Press, 2022. http://dx.doi.org/10.5117/9789463727556_ch04.

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The forced displacement of people was one of the most significant social consequences of the wars (1991-1995) which followed the dissolution of communist Yugoslavia. The Federal Republic of Yugoslavia, and particularly Serbia, has been widely affected by this process. Studies show that over 650,000 people (mostly from Bosnia and Herzegovina and Croatia) were forcibly displaced to Serbia. This chapter explores how the state and different religious communities responded to the forced displacement of populations in Serbia (1991-1996). It focuses on the responses of the state, through the work of
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Chandler, Oliver. "Introduction." In A Twelve-Tone Repertory for Guitar: Julian Bream and the British Serialists, 1956–1983. Guitar Foundation of America, 2023. http://dx.doi.org/10.56902/gfarm.2023.4.3.

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While the history of the formation of a modern British guitar repertoire around the central figure of Julian Bream is known in broad brushstrokes, we lack a thoroughgoing, technical understanding of the particular idiom that Bream’s composers developed. Important in the nascent stages of the guitar’s modernist evolution, for example, was its relationship to twelve-tone serialism. Through close readings of individual works by Reginald Smith Brindle (El polifemo de oro, 1956), Denis ApIvor (Variations, 1958), Thomas Wilson (Three Pieces, 1961; Soliloquy, 1969), and Richard Rodney Bennett (Improm
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Loevy, Karin. "Cycles of Compulsion." In Interrogation and Torture. Oxford University Press, 2020. http://dx.doi.org/10.1093/oso/9780190097523.003.0012.

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From the perspective of the security official, the practice of torture raises two interrelated compulsions: that of efficacy and that of legality. The compulsion of efficacy is expressed by the need to make sure that all state actions conform to an instrumental rationality. The compulsion of legality is the tendency to justify all state actions in terms of their reference to law. When a deeply ingrained knowledge that torture is necessary “to get the job done” interacts with the belief that legality is a necessary condition for all legitimate state actions, one can readily expect an ongoing pr
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Katsh, M. Ethan. "Introduction: Twain's Challenge and the Culture of Cyberspace." In Law in a Digital World. Oxford University PressNew York, NY, 1995. http://dx.doi.org/10.1093/oso/9780195080179.003.0001.

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Abstract In Life on the Mississippi, Mark Twain described his lifelong fascination with the Mississippi River and with the influence that the river had on the people and towns in the surrounding area. Through a series of stories and anecdotes about river life, Twain portrays the river not simply as a moving body of water, as a geographical entity, but as a dynamic component of life and culture in that time and place. One of Twain’s most telling experiences occurred when, as a young man, he was serving as an apprentice to a riverboat captain. While at the helm one day, Twain perceived danger lu
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Conference papers on the topic "Break Through Responders"

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Yan, Hong-Sen, and Kuo-Hung Hsiao. "The Development of Ancient Earthquake Instruments." In ASME 2006 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. ASMEDC, 2006. http://dx.doi.org/10.1115/detc2006-99107.

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This paper studies sensing element designs in ancient seismometers and describes the developments of ancient earthquake instruments. A basic seismograph comprises a seismometer, a recording system, and a timing system. The major difficulty in the development of a seismograph was the design of the seismometer. And, the break through was the use of a pendulum system as a sensing element that responded to ground motion and did not move with the ground. Early seismoscopes were primarily intended to determine that an earthquake had happened. The first seismoscope invented by Zhang Heng was Hou Feng
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Saxena, Rishi Rai, and Akshita Singh. "USING DATA-DRIVEN APPROACHES TO ADDRESS PSYCHOLOGICAL BARRIERS IN INTERDISCIPLINARY EDUCATION: BRIDGING SOCIAL SCIENCES AND TECHNOLOGY FOR EQUITABLE LEARNING." In Transforming Knowledge: A Multidisciplinary Research on Integrative Learning Across Disciplines. The Bhopal School of Social Sciences, 2025. https://doi.org/10.51767/ic250304.

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The rapid evolution of job markets needs continuous skill development to ensure that individuals stay relevant and adaptable in the competitive dynamic market. In the era of Artificial Intelligence, transformative fields have significant opportunities for learners from different academic backgrounds. However, non-technical students face psychological barriers which hinders their ability to learn these high demand skills. This study explores these barriers qualitatively, and identifies challenges faced by non-technical learners and the strategies to overcome them. The study conducted through a
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