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Journal articles on the topic 'Breast Cancer 25(OH)D Vitamin D'

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Published: 7 June 2025

Last updated: 2 August 2025

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1

Anak, Agung Ayu Ratih Dharmaiswari, and Kadek Sumantara Artha I. "Effectivity of Vitamin D in Preventing Breast Cancer and Evaluation of 25(OH)D Examination As A Laboratory Screening Tool." International Journal of Medical Science and Clinical Research Studies 5, no. 05 (2025): 696–701. https://doi.org/10.5281/zenodo.15347969.

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Vitamin D is currently associated with many diseases, not only bone health but also in autoimmune diseases, cancer, and neurological disorders. This study focuses on the mechanism relation vitamin D on breast cancer, especially with regard to estrogen receptor-positive (ER+) and human epidermal growth factor receptor 2-positive (HER 2+) cancers. Therapeutic supplementation is a commonly used approach to increase vitamin D levels. The effects of vitamin D have been investigated in various aspects, including regulation of cell growth and differentiation, apoptosis, intercellular contact, angioge

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Damayanti, Amilia Yuni, Dono Indarto, Brian Wasita, and Tonang Dwi Ardyanto. "Indeks massa tubuh, asupan vitamin D, dan serum 25-hydroxyvitamin D pada pasien kanker payudara." Jurnal Gizi Klinik Indonesia 14, no. 2 (2017): 56. http://dx.doi.org/10.22146/ijcn.17243.

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Background: Breast cancer is the most common malignancy in women in the world. Vitamin D helps control the majority of gene expression in female reproductive tissues. Body mass index (BMI) influences the bioavailability of vitamin D. Diet is one of the main sources of vitamin D and it is directly converted into 25-hydroxyvitamin D [25 (OH) D] in the liver.Objective: This study aimed to analyze the relationship between BMI and vitamin D intake and 25 (OH)D serum in patients with breast cancer.Method: Analytic observational with cross sectional design was used in this study. A total of 37 breast

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Jauhari, A. H. Asmali, N. Bhoo-Pathy, T. Islam, M. Y. Jalaludin, F. M. Moy, and N. A. Taib. "Serum 25(OH) Vitamin D Deficiency and Risk of Breast Cancer in Malaysia: A Case-Control Study." Journal of Global Oncology 4, Supplement 2 (2018): 23s. http://dx.doi.org/10.1200/jgo.18.64100.

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Background: Despite the emerging literature supporting the beneficial role of sufficient vitamin D level and its association with various cancers, current evidence on the vitamin D and the risk of getting breast cancer is still inconsistent. Furthermore, the study between vitamin D status and breast cancer risk among south east Asian women is limited. Aim: We aimed to investigate the association between vitamin D deficiency and the risk of getting breast cancer among Malaysian women. Methods: We conducted a retrospective nested case control study which consisted of Malaysian Breast Cancer Coho

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Zemlin, Cosima, Laura Altmayer, Caroline Stuhlert, et al. "Prevalence and Relevance of Vitamin D Deficiency in Newly Diagnosed Breast Cancer Patients: A Pilot Study." Nutrients 15, no. 6 (2023): 1450. http://dx.doi.org/10.3390/nu15061450.

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(1) Background: Vitamin D plays an important role in many types of cancer. It was the aim of this study to analyze serum 25-hydroxyvitamin D (25(OH)D) levels in newly diagnosed breast cancer patients, and the association with prognostic and lifestyle factors. (2) Methods: 110 non-metastatic breast cancer patients were included in the prospective observational “BEGYN” study at Saarland University Medical Center between September 2019 and January 2021. At the initiation visit, serum 25(OH)D levels were measured. Clinicopathological data on prognosis, nutrition, and lifestyle were extracted from

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Crew, Katherine D. "Vitamin D: Are We Ready to Supplement for Breast Cancer Prevention and Treatment?" ISRN Oncology 2013 (February 26, 2013): 1–22. http://dx.doi.org/10.1155/2013/483687.

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Vitamin D deficiency is a potentially modifiable risk factor that may be targeted for breast cancer prevention and treatment. Preclinical studies support various antitumor effects of vitamin D in breast cancer. Numerous observational studies have reported an inverse association between vitamin D status, including circulating 25-hydroxyvitamin D (25(OH)D) levels, and breast cancer risk. The relationship between vitamin D and mammographic density, a strong predictor of breast cancer risk, remains unclear. Studies analyzing the link between genetic polymorphisms in vitamin D pathway genes and bre

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Ilyan, Theresia, Dwi Retnoningrum, Meita Hendrianingtyas, Dian Widyaningrum, and Banundari Rachmawati. "Association of 25-hydroxyvitamin D, Cyclooxygenase-2 and Prostaglandin E2 Serum Levels in Breast Cancer Patients." Indonesian Biomedical Journal 13, no. 4 (2021): 426–32. http://dx.doi.org/10.18585/inabj.v13i4.1684.

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BACKGROUND: Serum levels of 25-hydroxyvitamin D (25(OH)D), prostaglandin E2 (PGE2), and cyclooxygenase 2 (COX2) expression differ between breast cancer stages. Since, previous studies showed mixed results, in this study, we aimed to analyze vitamin D levels related to breast cancer stages and serum levels of COX2 and PGE2 in Indonesia.METHODS: This was a cross sectional study involving 75 breast cancer patients. Subjects were divided into 3 groups, namely operable early stage (K1), locally advanced stage (K2), and advanced stage (K3). Venous blood samples were taken from each subject, then wer

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Radom, Agnieszka, Andrzej Wędrychowicz, Stanisław Pieczarkowski, Szymon Skoczeń, and Przemysław Tomasik. "Effect of Selected Factors on the Serum 25(OH)D Concentration in Women Treated for Breast Cancer." Nutrients 13, no. 2 (2021): 564. http://dx.doi.org/10.3390/nu13020564.

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Maintaining an optimal vitamin D concentration reduces the risk of recurrence and extends survival time in patients after breast cancer treatment. Data on vitamin D deficiency among Polish women after breast cancer therapy are limited. Thus, the aim of the study was the analysis of vitamin D status in post-mastectomy patients, considering such factors as seasons, social habits, vitamin D supplementation and its measurements. The study involved 94 women after breast cancer treatment. Serum vitamin D concentration was measured, and a questionnaire, gathering demographic and clinical data regardi

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Laney, Nathan, Jane Meza, Elizabeth Lyden, Judi Erickson, Kelly Treude, and Whitney Goldner. "The Prevalence of Vitamin D Deficiency Is Similar between Thyroid Nodule and Thyroid Cancer Patients." International Journal of Endocrinology 2010 (2010): 1–7. http://dx.doi.org/10.1155/2010/805716.

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Introduction. There are reported associations between vitamin D deficiency and breast, prostate, and colon cancer, but the relationship in thyroid cancer has not been evaluated.Methods. We evaluated serum calcium, creatinine, albumin, and 25-hydroxy vitamin D (25-OH-D) in 42 thyroid nodule, 45 thyroid cancer in remission, and 24 active thyroid cancer patients.Results. 25-OH-D was not different between groups. The percent with 25-OH-D levels<75 nmol/L was not significantly different between groups and was not affected by season of measurement, age, or cancer stage. Multivariate regression sh

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9

Butt, Maleeha Tahir. "Relation of Vitamin D Deficiency with Breast Cancer Staging in Patients from INMOL Cancer Hospital." Proceedings of Shaikh Zayed Medical Complex Lahore 35, no. 1 (2021): 27–32. http://dx.doi.org/10.47489/p000s351z7801-6mc.

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Introduction: Vitamin D deficiency can be critical and is reported to be as one of the factors for development and progression of breast carcinoma. Aims & Objectives: To measure and compare 25(OH)D (calcidiol) levels in healthy females and in breast carcinoma patients in four different stages. Place and duration of study: This cross sectional study and research was conducted in Shaikh Zayed Medical Complex in the Department of Biochemistry and Chemical Pathology from Jan 2018 to Jan 2019. The patients were selected from INMOL Cancer Hospital, Lahore. Material & Methods: The study was c

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Al-Rubiae, Sara Younis Mahmoud, and Salwa Hazim Almukhtar. "Association between Vitamin D levels and Breast Cancer at Mosul Nuclear Oncology Hospital: Case - Control study." Pakistan Journal of Medical and Health Sciences 15, no. 9 (2021): 2741–44. http://dx.doi.org/10.53350/pjmhs211592741.

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Breast tumor is the most common type of cancer found in women. The issue of whether levels of vitamin D are associated with an increased risk of breast cancer has been brought up. The study's goals are to learn whether low levels of vitamin D are linked to a greater risk of breast cancer. A case-control study was conducted in Mosul Nuclear Oncology Hospital to see how blood vitamin D concentrations, vitamin D supplementation, and sunlight exposure relate to breast cancer among women in Mosul. There were a total of 66 newly diagnosed histologically confirmed primary breast cancer cases among th

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Schömann-Finck, Matthias, and Jörg Reichrath. "Umbrella Review on the Relationship between Vitamin D Levels and Cancer." Nutrients 16, no. 16 (2024): 2720. http://dx.doi.org/10.3390/nu16162720.

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Background: Cancer is a growing public health problem and cancer is linked to vitamin D via several mechanisms. Recent umbrella reviews on the extra-skeletal effects of vitamin D did not turn their attention to cancer. Accordingly, an overview of the current state of research is needed. Materials and methods: An umbrella review was conducted to provide an overview of systematic reviews on the association between vitamin D and incidence or mortality of breast cancer, colorectal cancer, lung cancer, pancreatic cancer, and prostate cancer. Results: Inverse correlations were found between the vita

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Ganji, Vijay, Layan Sukik, Bushra Hoque, Linda Boutefnouchet, and Zumin Shi. "Association of Serum 25-Hydroxyvitamin D Concentration with Breast Cancer Risk in Postmenopausal Women in the US." Journal of Personalized Medicine 12, no. 6 (2022): 944. http://dx.doi.org/10.3390/jpm12060944.

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The association between serum 25-hydroxyvitamin D [25(OH)D] concentration and breast cancer risk in postmenopausal women is not well understood. The aim of this study was to investigate the association between serum 25(OH)D concentration and breast cancer in postmenopausal women in the United States using nationally representative sample surveys. We used the data from seven cycles of National Health and Nutrition Examination Surveys from 2001 to 2014. Participants were non-institutionalized postmenopausal women (n = 8108). In restricted cubic spline analysis, a significant, nonlinear, invert ‘

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Hu, Kejia, David Frederick Callen, Jiayuan Li, and Hong Zheng. "Circulating Vitamin D and Overall Survival in Breast Cancer Patients: A Dose-Response Meta-Analysis of Cohort Studies." Integrative Cancer Therapies 17, no. 2 (2017): 217–25. http://dx.doi.org/10.1177/1534735417712007.

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Studies have shown that vitamin D could have a role in breast cancer survival; however, the evidence of the relationship between patients’ vitamin D levels and their survival has been inconsistent. This meta-analysis explores possible dose-response relationships between vitamin D levels and overall survival by allowing for differences in vitamin D levels among populations of the various studies. Studies relating vitamin D (25-OH-D [25-hydroxyvitamin D]) levels in breast cancer patients with their survival were identified by searching PubMed and Embase. A pooled HR (hazard ratio) comparing the

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Gupta, D., K. Trukova, P. G. Vashi, A. Adams, G. M. Lambert, and C. A. Lammersfeld. "Association of serum 25-hydroxy vitamin D and body mass index in cancer." Journal of Clinical Oncology 27, no. 15_suppl (2009): 6625. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.6625.

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6625 Background: The association between vitamin D and obesity remains unsettled with studies reporting conflicting findings on the relationship between the two. This association assumes even greater importance in cancer because of the alleged role of vitamin D in cancer risk and survival. Currently, the dietary recommendations for Vitamin D do not take into account a person's body mass index (BMI). We investigated the relationship between serum 25-hydroxy-vitamin D [25(OH)D] and BMI in a large sample of cancer patients. Methods: A consecutive case series of 740 cancer patients seen at Cancer

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Crew, KD, T. Xiao, PS Thomas, et al. "Safety, Feasibility, and Biomarker Effects of High-Dose Vitamin D Supplementation Among Women at High Risk for Breast Cancer." International Journal of Food Science, Nutrition and Dietetics S1, no. 1 (2015): 1–9. https://doi.org/10.19070/2326-3350-SI01001.

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Vitamin D deficiency is a potentially modifiable risk factor that may be targeted for breast cancer prevention. We examined the safety, feasibility, and biomarker effects of high-dose vitamin D among women at high risk for breast cancer. Forty high-risk women, defined as a 5-year breast cancer risk ≥1.67% per the Gail model, lobular or ductal carcinoma in situ, were assigned to a 1-year intervention of vitamin D3 20,000 IU or 30,000 IU weekly. Participants were monitored for toxicity every 3 months, underwent serial blood draws at baseline, 6 and 12 months, and a digital mamm

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Waraztuty, Ika, Astrid Siska Pratiwi, Melya Susanti, Ira Astuti, and Zakirullah. "The Relationship of 25-Hydroxyvitamin D Plasma Levels with Breast Cancer Stadium Assessed from Menopause Status." Britain International of Exact Sciences (BIoEx) Journal 3, no. 1 (2021): 65–72. http://dx.doi.org/10.33258/bioex.v3i1.383.

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Breast cancer is a type of cancer with high incidence and mortality especially in developing countries. Vitamin D regulates the expression a number of genes involved in the development of cancer cells. The aim of this study is to analyze the relationship between 25-hydroxyvitamin D (25 (OH) D) plasma level with breast cancer stage based on menopausal status. This is an observational research method with cross sectional design. Research subjects were 53 newly diagnosed breast cancer patients and had not received chemotherapy. Menopausal status and stage data were obtained from interviews and me

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Bernhardt, Sarah M., and Pepper Schedin. "Abstract 4231: The anti-cancer effects of vitamin D are blocked postpartum due to suppression of vitamin D metabolism in the liver." Cancer Research 83, no. 7_Supplement (2023): 4231. http://dx.doi.org/10.1158/1538-7445.am2023-4231.

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Abstract Postpartum breast involution is a physiologic inflammatory process that associates with increased risk of postpartum breast cancer (PPBC). In rodents, involution promotes breast cancer progression, and treatment with anti-inflammatory agents is protective. These data provide rationale for targeting the pro-tumor window of involution with anti-inflammatory agents for PPBC prevention. Vitamin D is another anti-inflammatory agent with a good safety profile. In postpartum women, vitamin D deficiency is prevalent, suggesting vitamin D supplementation during involution may prevent developme

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Bernhardt, Sarah, Michelle Ozaki, Nicole Andeen, and Pepper Schedin. "Abstract 6435: Postpartum breast cancer, liver CYP450 metabolism and drug resistance." Cancer Research 85, no. 8_Supplement_1 (2025): 6435. https://doi.org/10.1158/1538-7445.am2025-6435.

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Postpartum breast involution is a physiologic inflammatory process associated with poor-prognostic, postpartum breast cancer (PPBC). In rodent models of PPBC, weaning-induced mammary and liver involution promote- and NSAIDs mitigate-mammary tumor growth and metastasis, providing rationale for targeting weaning with anti-inflammatory agents. Vitamin D3 is an anti-inflammatory agent with a good safety profile in lactating women. Vitamin D deficiency is also prevalent postpartum, suggesting vitamin D3 supplementation may mitigate the pro-tumor inflammatory milieu associated with postpartum breast

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Bissan, Aboubacar D. T., Madani Ly, Awo Emmanuela H. Amegonou, et al. "Plasma 25-Hydroxyvitamin D and 1,25-Dihydroxyvitamin D Levels in Breast Cancer Risk in Mali: A Case–Control Study." Diagnostics 13, no. 24 (2023): 3664. http://dx.doi.org/10.3390/diagnostics13243664.

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(1) Background: Breast cancer is the most prevalent cancer found in women in Mali. The aim of the current study was to determine the association between metabolites circulating in the blood, 25(OH)D and 1,25(OH)2D, and vitamin D levels with the risk of breast cancer in Malian women. (2) Methods: We conducted a prospective case–control study from August 2021 to March 2022. Control subjects were matched to cases according to age (within 5 years). The patients’ clinical stage was determined by the oncologist according to the tumour–nodes–metastasis (TNM) classification system. (3) Results: We obs

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Almeida-Filho, Benedito Souza, Michelle Sako Omodei, Daniel A. B. Buttros, et al. "Negative Impact of Vitamin D Deficiency at Diagnosis on Breast Cancer Survival: A Prospective Cohort Study." Breast Journal 2022 (June 1, 2022): 1–9. http://dx.doi.org/10.1155/2022/4625233.

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Objective. We prospectively evaluated the association between vitamin D concentration at diagnosis and overall survival (OS), disease-free survival (DFS), and cancer-specific survival (CSS) in postmenopausal women treated for breast cancer. Methods. This study included 192 patients newly diagnosed with invasive breast cancer, aged ≥45 years, and serum 25-hydroxy vitamin D (25 (OH)D) concentration assessment at diagnosis. Patients were classified into groups according to 25 (OH)D concentrations: sufficient (≥30 ng/mL), insufficient (between 20 and 29 ng/mL), and deficient (<20 ng/mL). The pr

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Wojtacki, Janusz, Agnieszka Labuc, and Piotr Banach. "Prevalence of vitamin D deficiency among palliative care cancer outpatients: Prospective analysis of 347 cases of single individual medical practice." Journal of Clinical Oncology 33, no. 29_suppl (2015): 204. http://dx.doi.org/10.1200/jco.2015.33.29_suppl.204.

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204 Background: In spite of the fact that cancer patients under palliative care represent the group of high risk for vitamin D deficiency (e.g. changed nutritional patterns and UV exposure), data reporting vitamin D levels in palliative care setting are rather scarce. Methods: Between Jan-02/2014 and June-20/2015 circulating 25-hydroxyvitamin-D (25-OH-D) levels were analyzed in 76% consecutive patients’ samples of a single individual cancer practice located in Gdansk, Poland. Three hundred forty seven patients (female: 72.5%, median age 64, range: 23-89 years; breast cancer: 57.8%, colon cance

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Jiang, Xia, Niki L. Dimou, Kawthar Al-Dabhani, et al. "Circulating vitamin D concentrations and risk of breast and prostate cancer: a Mendelian randomization study." International Journal of Epidemiology 48, no. 5 (2018): 1416–24. http://dx.doi.org/10.1093/ije/dyy284.

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Abstract Background Observational studies have suggested an association between circulating vitamin D concentrations [25(OH)D] and risk of breast and prostate cancer, which was not supported by a recent Mendelian randomization (MR) analysis comprising 15 748 breast and 22 898 prostate-cancer cases. Demonstrating causality has proven challenging and one common limitation of MR studies is insufficient power. Methods We aimed to determine whether circulating concentrations of vitamin D are causally associated with the risk of breast and prostate cancer, by using summary-level data from the larges

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Anisiewicz, Artur, Konrad Kowalski, Joanna Banach, et al. "Vitamin D Metabolite Profile in Cholecalciferol- or Calcitriol-Supplemented Healthy and Mammary Gland Tumor-Bearing Mice." Nutrients 12, no. 11 (2020): 3416. http://dx.doi.org/10.3390/nu12113416.

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To analyze if the prometastatic activity of calcitriol (active vitamin D3 metabolite), which was previously observed in a 4T1 breast cancer model, is also found in other breast cancers, and to assess the impact of various schemes of vitamin D supply, we used 4T1 and E0771 mouse metastatic and 67NR nonmetastatic cells in this study. BALB/c and C57BL/6 healthy and tumor-bearing mice were exposed to a control (1000 IU), low- (100 IU), and high- (5000 IU) vitamin D3 diets. Additionally, from day 7 of tumor transplantation, the 1000 and 100 IU groups were gavaged with calcitriol (+cal). After 8 wee

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Holder, Etienne. "Abstract P3-12-03: Pre-diagnostic plasma 25-hydroxyvitamin D and mortality among women with breast cancer in the nurses’ health study cohorts." Cancer Research 82, no. 4_Supplement (2022): P3–12–03—P3–12–03. http://dx.doi.org/10.1158/1538-7445.sabcs21-p3-12-03.

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Abstract Background: Sufficient levels of vitamin D are critical for optimal health. 25-hydroxyvitamin D (25(OH)D) is an essential steroid hormone, derived from sun exposure, diet, and supplement use, that is hypothesized to influence breast cancer prognosis by inhibiting breast tumor growth. While this has been observed in laboratory-based studies, findings from observational studies are inconclusive. We examined the association between pre-diagnostic 25(OH)D concentrations and both breast cancer-specific and overall mortality to explore the potential effects of vitamin D, a modifiable exposu

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Zemlin, Cosima, Laura Altmayer, Marina Lang, et al. "Course of Vitamin D Levels in Newly Diagnosed Non-Metastatic Breast Cancer Patients over One Year with Quarterly Controls and Substitution." Nutrients 16, no. 6 (2024): 854. http://dx.doi.org/10.3390/nu16060854.

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(1) Background: Vitamin D levels in patients remain inadequately understood, with research yielding inconsistent findings. Breast cancer patients, particularly due to oncological therapies, face an increased risk of osteopenia, which can be exacerbated by a vitamin D deficiency. (2) Methods: The prospective observational “BEGYN-1” study assessed serum 25(OH)D levels at baseline and quarterly thereafter. Clinical, pathological, nutritional, vitamin supplementation, and lifestyle data were recorded. (3) Results: Before treatment, 68.5% of patients were vitamin D deficient (<30 ng/mL), with 4.

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Pessoa, Eduardo, Michelle Omodei, Jackeline Chimicoviaki, et al. "Abstract P5-08-17: Effect of vitamin D supplementation on the pathological complete response to neoadjuvant chemotherapy in women with breast cancer: a randomized clinical trial." Clinical Cancer Research 31, no. 12_Supplement (2025): P5–08–17—P5–08–17. https://doi.org/10.1158/1557-3265.sabcs24-p5-08-17.

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Abstract Background: Vitamin D supplementation may be a potential non-toxic and low-cost tool to improve the pathological complete response in breast cancer patients undergoing neoadjuvant chemotherapy. Objective The study aimed to evaluate the effect of vitamin D supplementation on the pathological complete response (pCR) rate in women with breast cancer (BC) undergoing neoadjuvant chemotherapy (NCT). Methods: A randomized clinical trial was conducted on 80 women aged ≥45years with a diagnosis of BC, who were eligible for NCT. Women were randomized to one of two groups that received either da

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Ahmed, Jemal, Eyasu Makonnen, Alan Fotoohi, et al. "Vitamin D Status and Association of VDR Genetic Polymorphism to Risk of Breast Cancer in Ethiopia." Nutrients 11, no. 2 (2019): 289. http://dx.doi.org/10.3390/nu11020289.

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Emerging evidence associates vitamin D deficiency and vitamin D receptor (VDR) genetic variations with risk for breast cancer. This study investigated the prevalence of vitamin D deficiency and its association with tumor characteristics and the implications of VDR genetic variations for risk of breast cancer in Ethiopia. This unmatched case–control study involved 392 female breast cancer patients and 193 controls. The plasma 25-hydroxyvitamin D (25(OH)D3) level was quantified in chemotherapy-naïve (N = 112) and tamoxifen-treated patients (N = 89). Genotyping for the VDR common variant alleles

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Krivosheev, V. V., and E. V. Bilan. "Vitamin D deficiency and malignancies." Sanitarnyj vrač (Sanitary Doctor), no. 10 (October 11, 2023): 663–77. http://dx.doi.org/10.33920/med-08-2310-06.

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The analysis of domestic and foreign literature shows that oncological diseases are most often accompanied by a low level of 25(OH)D in the blood serum of patients and a high prevalence of deficiency and severe deficiency of vitamin D. It can be confidently stated that the level of 25(OH)D in serum blood of oncological patients, on average, is lower than in healthy people of the corresponding sex and age. In this regard, statistical studies were carried out, which demonstrated the prevalence of vitamin D deficiency in the countries of Europe and North America, which is directly proportional to

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Matsumoto, Yotaro, Atsushi Kittaka, and Tai C. Chen. "19-Norvitamin D analogs for breast cancer therapy." Canadian Journal of Physiology and Pharmacology 93, no. 5 (2015): 333–48. http://dx.doi.org/10.1139/cjpp-2014-0452.

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The active form of vitamin D3, 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3 or calcitriol), is known to inhibit the proliferation and invasiveness of many types of cancer cells, including breast, colon, pancreatic, prostate, and liver cancer cells. These findings support the use of 1α,25(OH)2D3 for the treatment of these types of cancer. However, 1α,25(OH)2D3 can cause hypercalcemia, so analogs of 1α,25(OH)2D3 that are less calcemic but exhibit more potent anti-tumor activity would be good candidates as therapeutic agents. Therefore, a series of 19-norvitamin D analogs, in which the methylidene gro

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Yum, Chaehyun, Chaylen Andolino, Brienna Larrick, Madeline P. Sheeley та Dorothy Teegarden. "1α,25-Dihydroxyvitamin D Downregulates Adipocyte Impact on Breast Cancer Cell Migration and Adipokine Release". Nutrients 16, № 18 (2024): 3153. http://dx.doi.org/10.3390/nu16183153.

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Background/Objectives: Excess adiposity is associated with a higher risk of breast cancer metastasis and mortality. Evidence suggests that dietary vitamin D inhibits breast cancer metastasis. However, the mechanistic link between vitamin D’s regulation of adipocyte metabolism and metastasis has not been previously investigated. Therefore, the purpose of these experiments was to examine the effect of the active form of vitamin D, 1α,25-dihydroxyvitamin D (1,25(OH)2D), on adipocyte release of bioactive compounds and whether the impact on adipocytes leads to inhibition of breast cancer cell migra

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Li, Jiarong, Aimée-Lee Luco, Benoît Ochietti та ін. "Tumoral Vitamin D Synthesis by CYP27B1 1-α-Hydroxylase Delays Mammary Tumor Progression in the PyMT-MMTV Mouse Model and Its Action Involves NF-κB Modulation". Endocrinology 157, № 6 (2016): 2204–16. http://dx.doi.org/10.1210/en.2015-1824.

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Biologically active vitamin D (1,25-dihydroxycholecalciferol or 1,25(OH)2D) is synthetized from inactive prohormone 25-hydroxycholecalciferol (25(OH)D) by the enzyme CYP27B1 1-α-hydroxylase in kidney and several extrarenal tissues including breast. Although the development of breast cancer has been linked to inadequate vitamin D status, the importance of bioactive vitamin D production within tumors themselves is not fully understood. To investigate the role of tumoral vitamin D production in mammary epithelial cell progression to breast cancer, we conducted a Cre-loxP-mediated Cyp27b1 gene abl

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Ortiz-Sánchez, Carmen, Jarline Encarnación-Medina, Ralphdy Vergne, Luis Padilla, and Jaime Matta. "Circulating Vitamin D Levels and DNA Repair Capacity in Four Molecular Subtypes of Women with Breast Cancer." International Journal of Molecular Sciences 21, no. 18 (2020): 6880. http://dx.doi.org/10.3390/ijms21186880.

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Vitamin D regulates estrogen synthesis among other mechanisms involved in breast cancer (BC) development; however, no evidence has been found regarding its relationship with DNA repair capacity (DRC). Therefore, the objective of this study was to elucidate whether DRC levels are linked with plasma 25(OH)D levels. BC cases and controls were selected from our BC cohort. DRC levels were assessed in lymphocytes through the host-cell reactivation assay. 25(OH)D levels were measured using the UniCel DxI 600 Access Immunoassay System. BC cases (n = 91) showed higher 25(OH)D levels than the controls (

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Vanhevel, Justine, Lieve Verlinden, Stefanie Doms, Hans Wildiers, and Annemieke Verstuyf. "The role of vitamin D in breast cancer risk and progression." Endocrine-Related Cancer 29, no. 2 (2022): R33—R55. http://dx.doi.org/10.1530/erc-21-0182.

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The active form of vitamin D3, 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), is primarily known as a key regulator of calcium and phosphate homeostasis. It exerts its biological functions by binding to the vitamin D receptor (VDR), a transcription factor that regulates gene expression in vitamin D-target tissues such as intestine, kidney and bone. Yet, the VDR is expressed in many additional normal and cancerous tissues, where it moderates the antiproliferative, prodifferentiating and immune-modulating effects of 1,25(OH)2D3. Interestingly, several epidemiological studies show that low levels of 25(

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Abd El Moneim, Nadia, Taha Hewala, Mona Rashad, Yousria Moussa, Nehal Abu-Samra, and Medhat Anwar. "The role of serum 25-hydroxyvitamin D, ionized calcium and phosphorus in breast cancer females: A case-control study." International Journal of Basic and Applied Sciences 4, no. 2 (2015): 228. http://dx.doi.org/10.14419/ijbas.v4i2.4563.

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<p><strong>Aim:</strong> To evaluate the diagnostic and prognostic value of serum 25- hydroxyvitamin D (25(OH) D), ionized calcium and phosphorus in comparison with serum CA15.3 as the most commonly used breast cancer marker.</p><p><strong>Participants and methods:</strong> This study was conducted on 45 breast cancer female patients with recently detected breast cancer before surgery and 45 apparently healthy female controls of matched age, menstrual and socioeconomic status as breast cancer patients group. Serum 25(OH) D, ionized calcium, phosphorus

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Shapiro, Alice C., Karen K. Swenson, MaryJo Nissen, et al. "Association between musculoskeletal symptoms and serum vitamin D levels in women receiving aromatase inhibitor treatment." Journal of Clinical Oncology 31, no. 15_suppl (2013): e20560-e20560. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.e20560.

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e20560 Background: Up to 40% of women with estrogen positive (ER+) breast cancer treated with aromatase inhibitors (AIs) experience musculoskeletal symptoms (AIMSS) such as bone pain, joint pain, joint stiffness, and muscle weakness that negatively impact functional ability. Previous reports indicate that vitamin D insufficiency is common in this patient population and that D supplementation might attenuate AIMSS by affecting muscle, bone and/or nerve metabolism. To test the association between AIMSS and serum 25(OH)D levels, we analyzed data collected as part of a pilot prospective study asse

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Zulkeflee, Hani Ajrina, Tuan Salwani Tuan Ismail, Tengku Ahmad Damitri Al-Astani Tengku Din, Maya Mazuwin Yahya, and Wan Faiziah Wan Abdul Rahman. "Association of Serum Vitamin D Level and Vitamin D Receptor Expression among Newly Diagnosed Breast Cancer." Sains Malaysiana 50, no. 11 (2021): 3321–32. http://dx.doi.org/10.17576/jsm-2021-5011-16.

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There is a mushrooming interest in the anti-carcinogenic property of vitamin D. However, many researches reported a conflicting result in the association of vitamin D levels to certain types of cancer. This study was designed to assess the association between vitamin D and vitamin D receptor (VDR) expression with breast cancer. This case-control study, carried out at Hospital Universiti Sains Malaysia, Kelantan, involved 69 newly diagnosed breast cancer patients and 73 healthy volunteers. Serum 25(OH)D was taken and compared between 2 groups. VDR expression in patients’ breast tissue samples w

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Isbilen, Elif, Tulay Kus, Havva Yesil Cinkir, Gokmen Aktas, and Aysegul Buyukbebeci. "Better survival associated with successful vitamin D supplementation in non-metastatic breast cancer survivors." Turkish Journal of Biochemistry 46, no. 5 (2021): 509–16. http://dx.doi.org/10.1515/tjb-2021-0137.

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Abstract Background We aimed to clarify whether successful vitamin D supplementation could predict improved survival in breast cancer (BC) survivors after completion of adjuvant treatment. Materials and Methods Patients were classified into four groups based on changes of 25(OH)D level during the treatment follow-up. Log-rank statistics were used to compare survival distributions among groups. ORs and 95% CIs were given for mortality ratios. Results The risk of death in group II with low 25(OH)D levels was 4.2 times higher than in group I with high 25(OH)D levels. (OR = 4.17 (95% CI = 1.46–11.

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Weinstein, Stephanie J., Dominick Parisi, Alison M. Mondul, et al. "Vitamin D binding protein genetic isoforms, serum vitamin D, and cancer risk in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial." PLOS ONE 19, no. 12 (2024): e0315252. https://doi.org/10.1371/journal.pone.0315252.

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Associations between vitamin D biochemical status and cancer may be modified by vitamin D binding protein isoforms which are encoded by GC (group-specific component). We examined interactions between serum 25-hydroxyvitamin D [25(OH)D], the Gc isoforms Gc1-1, Gc1-2, and Gc2-2, and cancer risk within the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial cohort based on 3,795 cases and 3,856 controls. Multivariable-adjusted logistic regression models estimated odds ratios (ORs) and 95% confidence intervals (CIs) of cancer risk according to 25(OH)D quantiles, stratified by Gc isoform

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Frolova, D. Е., N. P. Lapochkina, О. А. Gromova, and I. Yu Torshin. "Concentration of vitamin D metabolite – 25(OH)D3 as a predictor of breast cancer progression." FARMAKOEKONOMIKA. Modern Pharmacoeconomics and Pharmacoepidemiology 15, no. 4 (2023): 472–77. http://dx.doi.org/10.17749/2070-4909/farmakoekonomika.2022.152.

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Background. Prediction of breast cancer (BC) progression is important for the timely correction of patient therapy.Objective: to assess a relationship between BC progression and degree of vitamin D deficiency.Material and methods. A retrospective controlled study was performed. The results of examining 67 women aged 29–48 years with histologically verified BC and vitamin D deficiency are presented. All patients were divided into two groups: the main group – 34 women administered with vitamin D, comparison group – 33 patients not taking vitamin D.Results. It was shown that 25(OH)D3 level less t

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Trukova, K., D. Gupta, P. G. Vashi, et al. "Serum 25-hydroxy vitamin D and nutritional status: Implications for vitamin D assessment and dietary supplementation in oncology." Journal of Clinical Oncology 27, no. 15_suppl (2009): 9638. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.9638.

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9638 Background: There is emerging evidence in the literature to suggest a protective role of vitamin D in cancer survival. Vitamin D status is not routinely assessed, despite the high prevalence of malnutrition in this population. We hypothesized that malnutrition could contribute to vitamin D deficiency, and therefore expected mean serum 25-hydroxy-vitamin D [25(OH)D] levels to be significantly lower in malnourished oncology patients. Methods: A consecutive case series of 737 cancer patients seen at Cancer Treatment Centers of America between Jan-June 08. Nutritional status was assessed usin

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Bernhardt, Sarah M., and Pepper Schedin. "Abstract B079: Vitamin D metabolism is suppressed postpartum: Implications for targeting the postpartum window for cancer prevention." Cancer Research 84, no. 3_Supplement_1 (2024): B079. http://dx.doi.org/10.1158/1538-7445.advbc23-b079.

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Abstract Postpartum mammary gland involution is a physiologic inflammatory process that associates with increased risk of postpartum breast cancer (PPBC). Pre-clinical studies provide rationale for targeting this pro-tumor window of involution for PPBC prevention. However, the liver also undergoes physiological remodeling after weaning—consistent with weaning-induced mammary gland involution—which could potentially impact the efficacy of anti-cancer prodrugs administered during the postpartum period. Here, we used mouse models to test the efficacy of vitamin D, a prodrug with known anti-cancer

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Koczwara, Bogda, Richard John Woodman, Laisa Vicki Teleni, et al. "Variations in serum vitamin D status during cancer chemotherapy." Journal of Clinical Oncology 30, no. 15_suppl (2012): e19550-e19550. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.e19550.

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e19550 Background: Low serum vitamin D in cancer patients has been associated with inferior cancer outcomes and bone loss. The impact of chemotherapy on vitamin D levels is not known. We examined serum vitamin D levels during chemotherapy to identify magnitude and predictors of change. Methods: A prospective study of chemotherapy naïve patients commencing chemotherapy in two different sun exposure areas. Vitamin D (25(OH)D) deficiency was defined as ≤25 nmol/L and insufficiency 26-50 nmol/L. Demographic data, nutrition, sun exposure, season and biochemical parameters were collected at baseline

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Kimsa-Furdzik, Małgorzata, Anna Bednarek, Grzegorz Hibner, et al. "Vitamin D and Its Metabolites Status before and during Chemotherapy in Caucasian Breast Cancer Patients." Metabolites 13, no. 9 (2023): 996. http://dx.doi.org/10.3390/metabo13090996.

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Background: The predictive role of vitamin D (VD) in breast cancer (BC) patients’ survival is still being investigated. This paper aims to evaluate the changes in VD metabolites during chemotherapy (CTH) and the predictive role of VD status in Caucasian BC patients treated with CTH. Methods: Vitamin D and its metabolites were assessed with reference LC–MS/MS methodology in 98 consecutive BC patients starting CHT, after 3 and 6 months, and compared to the control group. Results: The frequency of VD deficiency in BC patients was greater than in the control group (56.1% vs. 37.2%). After 6 months

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Syafei, Zakirullah, Sri W. Suryani, and Denny S. Rifsal. "Hubungan kadar vitamin D plasma dengan IMT dan umur pada kanker payudara." AcTion: Aceh Nutrition Journal 3, no. 2 (2018): 117. http://dx.doi.org/10.30867/action.v3i2.110.

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Breast cancer is the most common type of cancer in women worldwide. Statistics show breast cancer is the second leading cause of death after lung cancer. Vitamin D is believed to have anti-carcinogenic properties independently effective in protecting against breast cancer, biologically active vitamin D, can inhibit cell proliferation, induction of differentiation and apoptosis and inhibit angiogenesis in normal and malignant breast cells. Basal metabolic index (BMI) affects the bioavailability of vitamin D. Also the incidence of cancer increases with age, especially the age group> 40 years.

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Krusinska, Beata, Lidia Wadolowska, Maciej Biernacki, Malgorzata Anna Slowinska, and Marek Drozdowski. "Serum ‘Vitamin-Mineral’ Profiles: Associations with Postmenopausal Breast Cancer Risk Including Dietary Patterns and Supplementation. A Case-Control Study." Nutrients 11, no. 9 (2019): 2244. http://dx.doi.org/10.3390/nu11092244.

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Breast cancer is the most prevalent cancer in females worldwide. Studies evaluating the blood vitamins and minerals status in the breast cancer etiology are limited, and the results are inconclusive. This study analyzed the association between serum vitamin-mineral profiles (V-MPs) and breast cancer (BC) risk with including dietary patterns (DPs) and the use of supplements. This case-control study involved 420 women aged 40–79 years from north-eastern Poland, including 190 newly diagnosed breast cancer cases. The fasting serum concentrations of vitamins (folate, cobalamin, 25(OH) vitamin D) an

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Т., Ф. Татарчук, Д. Дейнюк К., В. Занько О., І. Юско Т., and О. Тарнопольська В. "Vitamin D-deficiency states in the genesis of woman reproductive health disorders." Reproductive Endocrinology, no. 41 (June 15, 2018): 84–94. https://doi.org/10.18370/2309-4117.2018.41.84-94.

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Thanks to the continuous scientific and creative search for researchers over the past almost hundred years, vitamin D preparations are finding increasing uses, from classical prevention of rickets and osteomalacia to the prevention of malignant neoplasms and mental illnesses. The article discusses the use of vitamin D in the genesis of women reproductive health disorders, as well as its impact on the condition of women in different periods - childhood, the age of menarche and adolescence, the reproductive age and the menopause. The influence of vitamin D deficiency on a number of diseases, in

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Nikolac Gabaj, Nora, Tomislav Pavicic, Alen Vrtaric, et al. "In sickness and in health: pivotal role of vitamin D." Biochemia medica 30, no. 2 (2020): 202–14. http://dx.doi.org/10.11613/bm.2020.020501.

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Within the last several years, frequency of vitamin D testing has multiplied substantially all over the world, since it has been shown to have an important role in many diseases and conditions. Even though liquid chromatography - tandem mass spectrometry (LC-MS/MS) has been identified as “gold standard” method for vitamin D measurement, most laboratories still use immunochemistry methods. Besides analytical problems (hydrophobicity, low circulating concentrations, ability to bind to lipids, albumins and vitamin D binding protein, presence of multiple vitamin D metabolites and variable ratios o

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Blasiak, Janusz, Elzbieta Pawlowska, Jan Chojnacki, Joanna Szczepanska, Michal Fila, and Cezary Chojnacki. "Vitamin D in Triple-Negative and BRCA1-Deficient Breast Cancer—Implications for Pathogenesis and Therapy." International Journal of Molecular Sciences 21, no. 10 (2020): 3670. http://dx.doi.org/10.3390/ijms21103670.

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Several studies show that triple-negative breast cancer (TNBC) patients have the lowest vitamin D concentration among all breast cancer types, suggesting that this vitamin may induce a protective effect against TNBC. This effect of the active metabolite of vitamin D, 1α,25-dihydroxyvitamin D3 (1,25(OH)2D), can be attributed to its potential to modulate proliferation, differentiation, apoptosis, inflammation, angiogenesis, invasion and metastasis and is supported by many in vitro and animal studies, but its exact mechanism is poorly known. In a fraction of TNBCs that harbor mutations that cause

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Chlebowski, R. T., K. C. Johnson, C. Kooperberg, et al. "The Women’s Health Initiative randomized trial of calcium plus vitamin D: Effects on breast cancer and arthralgias." Journal of Clinical Oncology 24, no. 18_suppl (2006): LBA6. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.lba6.

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LBA6 Background: Calcium (Ca) and vitamin D (D) have been associated with reduced breast cancer and breast density in observational studies. Randomized trials have not evaluated Ca/D supplementation for breast cancer prevention. Methods: We randomized 36,282 postmenopausal women without prior breast cancer from 40 WHI centers to 1000 mg of elemental calcium as calcium carbonate and 400 IU of vitamin D3 (N = 18,176) daily or matching placebo (N = 18,106); 54% were also randomized one year previously to hormone therapy (HT) or placebo; conjugated equine estrogen (CEE) plus medroxyprogesterone ac

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Kim, Y., and Y. Je. "Vitamin D intake, blood 25(OH)D levels, and breast cancer risk or mortality: a meta-analysis." British Journal of Cancer 110, no. 11 (2014): 2772–84. http://dx.doi.org/10.1038/bjc.2014.175.

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