Relevant bibliographies by topics / Breast cancer Drug loading Drug release PLA

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Academic literature on the topic 'Breast cancer Drug loading Drug release PLA'

Author: Grafiati
Published: 2 June 2025
Last updated: 31 July 2025

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Journal articles on the topic "Breast cancer Drug loading Drug release PLA"

1

Efthimiadou, Eleni. "Novel PLA modification of organic microcontainers based on ring opening polymerization: Synthesis, characterization, biocompatibility and drug loading/release properties." International journal of pharmaceutics 428, no. 1-2 (2012): 134–42. https://doi.org/10.1016/j.ijpharm.2012.02.030.

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In the current study, poly lactic acid (PLA) modified hollow crosslinked poly(hydroxyethyl methacrylate) (PHEMA) microspheres have been prepared, in order to obtain a stimulus-responsive, biocompatible carrier with sustained drug release properties. The synthetical process consisted of the preparation of poly(methacrylic acid)@poly(hydroxyethyl methacrylate-co-N,N′-methylene bis(acrylamide)) microspheres by a two stage distillation-precipitation polymerization technique using 2,2′-azobisisobutyronitrile as initiator. Following core removal, a PLA coating of the microspheres was formed, after r
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Wang, Jun, Feng-Mei Lv, Dong-Li Wang, et al. "Synergistic Antitumor Effects on Drug-Resistant Breast Cancer of Paclitaxel/Lapatinib Composite Nanocrystals." Molecules 25, no. 3 (2020): 604. http://dx.doi.org/10.3390/molecules25030604.

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Drug resistance presents serious difficulties for cancer treatment. A combination of paclitaxel (PTX) and lapatinib (LAPA) shows potentials in multiple drug resistant cancers in the clinic, but it is almost impossible to deliver these two drugs to the tumor at the same time with the best proportion by simple co-administration of the respective current formualtions for their different pharmacokinetic profiles. Here composite nanocrystals of PTX and LAPA (cNC) were designed with a ratio of 2:1 (w/w), which was their intracellular ratio at the best synergistic efficacy on a drug-resistant cancer
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Gumushan Aktas, Hatice. "Chemotherapeutic Drug Delivery from 3D-Printed Biodegradable Polymer for Breast Cancer Treatment." Commagene Journal of Biology 9, no. 1 (2025): 103–11. https://doi.org/10.31594/commagene.1667137.

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The controlled delivery of chemotherapeutic agents is critical for enhancing therapeutic efficiency and minimizing side effects in cancer treatment. This study investigates the drug release, thermal stability, and mechanical performance of polylactic acid (PLA) resin doped with boric acid (H₃BO₃) and 5-fluorouracil (5-FU), fabricated through digital light processing (DLP) 3D printing technology. Samples with various concentrations of 5-FU (0-30 wt.%) and 1 wt.% boric acid were prepared and characterized structurally, mechanically, thermally, and biologically. Incorporation of 1% H₃BO₃ improved
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4

Kim, Won Jung, Eu Hyun Lee, Yong-Jin Kwon, Sang-Kyu Ye, and Kyu oh Kim. "Targeted drug release system based on pH-responsive PAA-POSS nanoparticles." RSC Advances 12, no. 28 (2022): 18209–14. http://dx.doi.org/10.1039/d2ra01141g.

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pH-sensitive PAA-POSS@DOX nanoparticles were synthesized and showed high loading efficiency of over 75% and doxorubicin was quickly released to the target area. The ability of PAA-POSS@DOX to kill MDA-MB-231 breast cancer cells has been demonstrated.
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Chen, Qiang, Xiaoyu Huang, Geyi Zhang, Jiangnan Li, Yang Liu, and Xu Yan. "Novel targeted pH-responsive drug delivery systems based on PEGMA-modified bimetallic Prussian blue analogs for breast cancer chemotherapy." RSC Advances 13, no. 3 (2023): 1684–700. http://dx.doi.org/10.1039/d2ra06631a.

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Liu, Gao, Zhou, et al. "Polydopamine-Based “Four-in-One” Versatile Nanoplatforms for Targeted Dual Chemo and Photothermal Synergistic Cancer Therapy." Pharmaceutics 11, no. 10 (2019): 507. http://dx.doi.org/10.3390/pharmaceutics11100507.

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Abstract: The development of versatile nanoscale drug delivery systems that integrate with multiple therapeutic agents or methods and improve the efficacy of cancer therapy is urgently required. To satisfy this demand, polydopamine (PDA)-modified polymeric nanoplatforms were constructed for the dual loading of chemotherapeutic drugs. The hydrophobic anticancer drug docetaxel (DTX) was loaded into the polymeric nanoparticles (NPs) which were fabricated from the star-shaped copolymer CA-PLGA. Then DTX-loaded NPs were coated with PDA, followed by conjugation of polyelethyl glycol (PEG)-modified t
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7

Suksiriworapong, Jiraphong, Chittin Achayawat, Phutthikom Juangrattanakamjorn, et al. "Modification of Poly(Glycerol Adipate) with Tocopherol and Cholesterol Modulating Nanoparticle Self-Assemblies and Cellular Responses of Triple-Negative Breast Cancer Cells to SN-38 Delivery." Pharmaceutics 15, no. 8 (2023): 2100. http://dx.doi.org/10.3390/pharmaceutics15082100.

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This study aimed to fabricate new variations of glycerol-based polyesters by grafting poly(glycerol adipate) (PGA) with hydrophobic bioactive moieties, tocopherol (TOC), and cholesterol (CHO). Their effects on nanoparticle (NP) formation, drug release, and cellular responses in cancer and normal cells were evaluated. CHO and TOC were successfully grafted onto PGA backbones with 30% and 50% mole grafting. Increasing the percentage of mole grafting in both molecules increased the glass transition temperature and water contact angle of the final polymers but decreased the critical micelle concent
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8

Kharbanda, Surender M., Sachchidanand Tiwari, Harshdeep Kaur, Anees Mohammad, Priya Gupta, and Harpal Singh. "Abstract 2718: Co-loading of a novel PI3-Kdelta/HDAC6 dual inhibitor and navitoclax into QuatramerTM biodegradable polymeric nanoparticles synergistically inhibit growth of ER+breast cancer." Cancer Research 83, no. 7_Supplement (2023): 2718. http://dx.doi.org/10.1158/1538-7445.am2023-2718.

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Abstract Progression and metastasis of ER+ breast cancer depends on multiple signaling cascades. The available conventional treatment options have limited efficacy in ER+ breast cancer. Simultaneous targeting and inhibition of multiple pathways in ER+ cancer may result in effective therapeutic outcomes. However, combining two or more drugs to treat cancer leads to unsynchronized pharmacokinetics, toxicity and eventual development of drug resistance. To overcome these limitations, a novel nano-formulation of PI3-Kδ/HDAC6 dual inhibitor in combination with Navitoclax (NAV; BCL-2 and BCL-xL inhib
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Kharbanda, Surender, Anees Mohammad, Sachchidanand Tiwari, et al. "Co-loading of an anthracycline analogue Pirarubicin and Salinomycin in a 1:3 ratio into Quatramerbiodegradable polymeric nanoparticles synergistically inhibit growth of triple-negative breast cancer." Journal of Clinical Oncology 39, no. 15_suppl (2021): e15047-e15047. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.e15047.

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e15047 Background: Triple negative breast cancer (TNBC) accounts for about 10-15% of all breast cancers and differ from other types of invasive breast cancers in that they grow and spread faster. TNBCs have limited treatment options and a worse prognosis. Therapy with anthracyclines considered to be one of the most effective agents in the treatment. Unfortunately, resistance to anthracycline therapy is very common due to drug efflux mediated by overexpression of ABC transporter. Pirarubicin (PIRA), an analogue of doxorubicin (DOX), is approved in Japan, Korea and China and is shown to be less
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10

Efthimiadou, Eleni. "New approach in synthesis, characterization and release study of pH-sensitive polymeric micelles, based on PLA-Lys-b-PEGm, conjugated with doxorubicin." Journal of nanoparticle research 13, no. 12 (2011): 6725–36. https://doi.org/10.1007/s11051-011-0579-5.

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Amphiphilic block copolymers are well established as building blocks for the preparation of micellar drug carriers. The functional polymer micelles possess several advantages, such as high drug efficiency, targeted delivery, and minimized cytotoxicity. The synthesis of block copolymers using nanostructured templates has emerged as a useful and versatile approach for preparing drug carriers. Here, we report the synthesis of a smart polymeric compound of a diblock PLA-Lys-b-PEG copolymer containing doxorubicin. We have synthesized functionalized diblock copolymers, with lysinol, poly(lactide) an
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Conference papers on the topic "Breast cancer Drug loading Drug release PLA"

1

Liu, Wing Kam, and Ashfaq Adnan. "Multiscale Modeling and Simulation for Nanodiamond-Based Therapeutic Delivery." In ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology. ASMEDC, 2010. http://dx.doi.org/10.1115/nemb2010-13273.

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It has been demonstrated from recent research that nanodiamond(ND)-enabled drug delivery as cancer therapeutics represents an important component of optimized device functionality. The goal of the current research is to develop a multiscale modeling technique to understand the fundamental mechanism of a ND-based cancer therapeutic drug delivery system. The major components of the proposed device include nanodiamonds (ND), parylene buffer layer and doxorubicin (DOX) drugs, where DOX loaded self-assembled nanodiamonds are packed inside parylene capsule. The efficient functioning of the device is
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