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Journal articles on the topic 'Breast cancer Drug loading Drug release PLA'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Efthimiadou, Eleni. "Novel PLA modification of organic microcontainers based on ring opening polymerization: Synthesis, characterization, biocompatibility and drug loading/release properties." International journal of pharmaceutics 428, no. 1-2 (2012): 134–42. https://doi.org/10.1016/j.ijpharm.2012.02.030.

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In the current study, poly lactic acid (PLA) modified hollow crosslinked poly(hydroxyethyl methacrylate) (PHEMA) microspheres have been prepared, in order to obtain a stimulus-responsive, biocompatible carrier with sustained drug release properties. The synthetical process consisted of the preparation of poly(methacrylic acid)@poly(hydroxyethyl methacrylate-co-N,N′-methylene bis(acrylamide)) microspheres by a two stage distillation-precipitation polymerization technique using 2,2′-azobisisobutyronitrile as initiator. Following core removal, a PLA coating of the microspheres was formed, after r

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Wang, Jun, Feng-Mei Lv, Dong-Li Wang, et al. "Synergistic Antitumor Effects on Drug-Resistant Breast Cancer of Paclitaxel/Lapatinib Composite Nanocrystals." Molecules 25, no. 3 (2020): 604. http://dx.doi.org/10.3390/molecules25030604.

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Drug resistance presents serious difficulties for cancer treatment. A combination of paclitaxel (PTX) and lapatinib (LAPA) shows potentials in multiple drug resistant cancers in the clinic, but it is almost impossible to deliver these two drugs to the tumor at the same time with the best proportion by simple co-administration of the respective current formualtions for their different pharmacokinetic profiles. Here composite nanocrystals of PTX and LAPA (cNC) were designed with a ratio of 2:1 (w/w), which was their intracellular ratio at the best synergistic efficacy on a drug-resistant cancer

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3

Gumushan Aktas, Hatice. "Chemotherapeutic Drug Delivery from 3D-Printed Biodegradable Polymer for Breast Cancer Treatment." Commagene Journal of Biology 9, no. 1 (2025): 103–11. https://doi.org/10.31594/commagene.1667137.

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The controlled delivery of chemotherapeutic agents is critical for enhancing therapeutic efficiency and minimizing side effects in cancer treatment. This study investigates the drug release, thermal stability, and mechanical performance of polylactic acid (PLA) resin doped with boric acid (H₃BO₃) and 5-fluorouracil (5-FU), fabricated through digital light processing (DLP) 3D printing technology. Samples with various concentrations of 5-FU (0-30 wt.%) and 1 wt.% boric acid were prepared and characterized structurally, mechanically, thermally, and biologically. Incorporation of 1% H₃BO₃ improved

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4

Kim, Won Jung, Eu Hyun Lee, Yong-Jin Kwon, Sang-Kyu Ye, and Kyu oh Kim. "Targeted drug release system based on pH-responsive PAA-POSS nanoparticles." RSC Advances 12, no. 28 (2022): 18209–14. http://dx.doi.org/10.1039/d2ra01141g.

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pH-sensitive PAA-POSS@DOX nanoparticles were synthesized and showed high loading efficiency of over 75% and doxorubicin was quickly released to the target area. The ability of PAA-POSS@DOX to kill MDA-MB-231 breast cancer cells has been demonstrated.

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Chen, Qiang, Xiaoyu Huang, Geyi Zhang, Jiangnan Li, Yang Liu, and Xu Yan. "Novel targeted pH-responsive drug delivery systems based on PEGMA-modified bimetallic Prussian blue analogs for breast cancer chemotherapy." RSC Advances 13, no. 3 (2023): 1684–700. http://dx.doi.org/10.1039/d2ra06631a.

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6

Liu, Gao, Zhou, et al. "Polydopamine-Based “Four-in-One” Versatile Nanoplatforms for Targeted Dual Chemo and Photothermal Synergistic Cancer Therapy." Pharmaceutics 11, no. 10 (2019): 507. http://dx.doi.org/10.3390/pharmaceutics11100507.

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Abstract: The development of versatile nanoscale drug delivery systems that integrate with multiple therapeutic agents or methods and improve the efficacy of cancer therapy is urgently required. To satisfy this demand, polydopamine (PDA)-modified polymeric nanoplatforms were constructed for the dual loading of chemotherapeutic drugs. The hydrophobic anticancer drug docetaxel (DTX) was loaded into the polymeric nanoparticles (NPs) which were fabricated from the star-shaped copolymer CA-PLGA. Then DTX-loaded NPs were coated with PDA, followed by conjugation of polyelethyl glycol (PEG)-modified t

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Suksiriworapong, Jiraphong, Chittin Achayawat, Phutthikom Juangrattanakamjorn, et al. "Modification of Poly(Glycerol Adipate) with Tocopherol and Cholesterol Modulating Nanoparticle Self-Assemblies and Cellular Responses of Triple-Negative Breast Cancer Cells to SN-38 Delivery." Pharmaceutics 15, no. 8 (2023): 2100. http://dx.doi.org/10.3390/pharmaceutics15082100.

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This study aimed to fabricate new variations of glycerol-based polyesters by grafting poly(glycerol adipate) (PGA) with hydrophobic bioactive moieties, tocopherol (TOC), and cholesterol (CHO). Their effects on nanoparticle (NP) formation, drug release, and cellular responses in cancer and normal cells were evaluated. CHO and TOC were successfully grafted onto PGA backbones with 30% and 50% mole grafting. Increasing the percentage of mole grafting in both molecules increased the glass transition temperature and water contact angle of the final polymers but decreased the critical micelle concent

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Kharbanda, Surender M., Sachchidanand Tiwari, Harshdeep Kaur, Anees Mohammad, Priya Gupta, and Harpal Singh. "Abstract 2718: Co-loading of a novel PI3-Kdelta/HDAC6 dual inhibitor and navitoclax into QuatramerTM biodegradable polymeric nanoparticles synergistically inhibit growth of ER+breast cancer." Cancer Research 83, no. 7_Supplement (2023): 2718. http://dx.doi.org/10.1158/1538-7445.am2023-2718.

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Abstract Progression and metastasis of ER+ breast cancer depends on multiple signaling cascades. The available conventional treatment options have limited efficacy in ER+ breast cancer. Simultaneous targeting and inhibition of multiple pathways in ER+ cancer may result in effective therapeutic outcomes. However, combining two or more drugs to treat cancer leads to unsynchronized pharmacokinetics, toxicity and eventual development of drug resistance. To overcome these limitations, a novel nano-formulation of PI3-Kδ/HDAC6 dual inhibitor in combination with Navitoclax (NAV; BCL-2 and BCL-xL inhib

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Kharbanda, Surender, Anees Mohammad, Sachchidanand Tiwari, et al. "Co-loading of an anthracycline analogue Pirarubicin and Salinomycin in a 1:3 ratio into Quatramerbiodegradable polymeric nanoparticles synergistically inhibit growth of triple-negative breast cancer." Journal of Clinical Oncology 39, no. 15_suppl (2021): e15047-e15047. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.e15047.

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e15047 Background: Triple negative breast cancer (TNBC) accounts for about 10-15% of all breast cancers and differ from other types of invasive breast cancers in that they grow and spread faster. TNBCs have limited treatment options and a worse prognosis. Therapy with anthracyclines considered to be one of the most effective agents in the treatment. Unfortunately, resistance to anthracycline therapy is very common due to drug efflux mediated by overexpression of ABC transporter. Pirarubicin (PIRA), an analogue of doxorubicin (DOX), is approved in Japan, Korea and China and is shown to be less

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10

Efthimiadou, Eleni. "New approach in synthesis, characterization and release study of pH-sensitive polymeric micelles, based on PLA-Lys-b-PEGm, conjugated with doxorubicin." Journal of nanoparticle research 13, no. 12 (2011): 6725–36. https://doi.org/10.1007/s11051-011-0579-5.

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Amphiphilic block copolymers are well established as building blocks for the preparation of micellar drug carriers. The functional polymer micelles possess several advantages, such as high drug efficiency, targeted delivery, and minimized cytotoxicity. The synthesis of block copolymers using nanostructured templates has emerged as a useful and versatile approach for preparing drug carriers. Here, we report the synthesis of a smart polymeric compound of a diblock PLA-Lys-b-PEG copolymer containing doxorubicin. We have synthesized functionalized diblock copolymers, with lysinol, poly(lactide) an

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Hendawy, Omnia M., Mohammad M. Al-Sanea, Rehab M. Elbargisy, et al. "Phenylboronic Acid-Grafted Chitosan Nanocapsules for Effective Delivery and Controllable Release of Natural Antioxidants: Olive Oil and Hydroxytyrosol." Pharmaceutics 15, no. 1 (2022): 81. http://dx.doi.org/10.3390/pharmaceutics15010081.

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Olives and virgin olive oil (VOO) are a staple of Mediterranean diets and are rich in several beneficial phenolic compounds, including hydroxytyrosol (HT). Therefore, VOO was extracted from Koroneiki olive fruits, and its volatile as well as phenolic components were identified. Meanwhile, in order to upgrade the pharmaceutical capabilities of VOO and HT, a new conjugate phenylboronic acid-chitosan nanoparticles (PBA-CSNPs, NF-1) was fabricated and applied as nanocapsules for implanting high loading and efficient delivery of VOO and HT nanoformulations (NF-2 and NF-3). Due to the H-bonding inte

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12

Dai, Shulin, Yucheng Feng, Shuyi Li та ін. "Stereocomplexation Assisted Assembly of Poly(γ-glutamic Acid)-graft-polylactide Nano-micelles and Their Efficacy as Anticancer Drug Carrier". Anti-Cancer Agents in Medicinal Chemistry 18, № 2 (2018): 302–11. http://dx.doi.org/10.2174/1871520617666170911170104.

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Background: Micelles as drug carriers are characterized by their inherent instability due to the weak physical interactions that facilitate the self-assembly of amphiphilic block copolymers. As one of the strong physical interactions, the stereocomplexation between the equal molar of enantiomeric polylactides, i.e., the poly(L-lactide) (PLLA) and poly(D-lactide) (PDLA), may be harnessed to obtain micelles with enhanced stability and drug loading capacity and consequent sustained release. </P><P> Aims/Methods: In this paper, stereocomplexed micelles gama-PGA-g-PLA micelles) were fab

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Jelonek, Katarzyna, Alicja Zajdel, Adam Wilczok, et al. "Comparison of PLA-Based Micelles and Microspheres as Carriers of Epothilone B and Rapamycin. The Effect of Delivery System and Polymer Composition on Drug Release and Cytotoxicity against MDA-MB-231 Breast Cancer Cells." Pharmaceutics 13, no. 11 (2021): 1881. http://dx.doi.org/10.3390/pharmaceutics13111881.

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Co-delivery of epothilone B (EpoB) and rapamycin (Rap) increases cytotoxicity against various kinds of cancers. However, the current challenge is to develop a drug delivery system (DDS) for the simultaneous delivery and release of these two drugs. Additionally, it is important to understand the release mechanism, as well as the factors that affect drug release, in order to tailor this process. The aim of this study was to analyze PLA–PEG micelles along with several types of microspheres obtained from PLA or a mixture of PLA and PLA–PEG as carriers of EpoB and Rap for their drug release propert

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Jelonek, Katarzyna, Monika Musiał-Kulik, Małgorzata Pastusiak, Aleksander Foryś, Andrzej Zięba, and Janusz Kasperczyk. "Exploring Micelles and Nanospheres as Delivery Systems for Phenothiazine Derivatives in Cancer Therapy." Pharmaceutics 16, no. 12 (2024): 1597. https://doi.org/10.3390/pharmaceutics16121597.

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Objectives: Cancer remains one of the leading causes of death worldwide, and thus, there is a need for the development of innovative and more effective treatment strategies. The aim of the study was to evaluate two types of nanoparticles—nanospheres and micelles—obtained from PLA-based polymers to discover their potential for delivering four types of phenothiazine derivatives. Methods: The morphology, drug-loading properties, cytocompatibility, hemolytic properties and anticancer activity were analyzed. Results: The micelles exhibited significantly higher drug-loading properties, release proce

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15

Im, Seung Hyuk, Dam Hyeok Im, Su Jeong Park, Justin Jihong Chung, Youngmee Jung, and Soo Hyun Kim. "Stereocomplex Polylactide for Drug Delivery and Biomedical Applications: A Review." Molecules 26, no. 10 (2021): 2846. http://dx.doi.org/10.3390/molecules26102846.

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Polylactide (PLA) is among the most common biodegradable polymers, with applications in various fields, such as renewable and biomedical industries. PLA features poly(D-lactic acid) (PDLA) and poly(L-lactic acid) (PLLA) enantiomers, which form stereocomplex crystals through racemic blending. PLA emerged as a promising material owing to its sustainable, eco-friendly, and fully biodegradable properties. Nevertheless, PLA still has a low applicability for drug delivery as a carrier and scaffold. Stereocomplex PLA (sc-PLA) exhibits substantially improved mechanical and physical strength compared t

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16

Chang, Jing, Zhe Yang, Junfeng Li, et al. "Preparation and In Vitro and In Vivo Antitumor Effects of VEGF Targeting Micelles." Technology in Cancer Research & Treatment 19 (January 1, 2020): 153303382095702. http://dx.doi.org/10.1177/1533033820957022.

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Background: Doxorubicin (DOX) has antitumor effects mediated by cell viability inhibition and by inducing cellular apoptosis. However, it has limited use in clinical applications due to various factors such as hydrophobicity, dose-dependent toxicity effects on normal tissues, short cycle retention time, and low targeting ability. This study aims at enhancing hydrophilicity of DOX to restrict its toxic effects to within or around the tumor sites and also to improve its targeting ability to enhance antitumor efficiency. Methods: Micelles composed of biodegradable poly (ethylene glycol)-poly (lac

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17

Kesharwani, Prashant, Shadab Md, Nabil A. Alhakamy, Khaled M. Hosny, and Anzarul Haque. "QbD Enabled Azacitidine Loaded Liposomal Nanoformulation and Its In Vitro Evaluation." Polymers 13, no. 2 (2021): 250. http://dx.doi.org/10.3390/polym13020250.

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Azacitidine (AZA), an inhibitor of DNA methyltransferase, is a commonly recognized drug used in clinical treatment for myelodysplastic syndrome and breast cancer. Due to higher aqueous solubility and negative log P of AZA causes poor cancer cell permeation and controlled release. The objective of the present study was to formulate and optimize AZA-loaded liposome (AZA-LIPO) for breast cancer chemotherapy by using Box Behnken design (BBD) and in vitro evaluation using MCF-7 cells. AZA-LIPO were prepared using a thin film hydration technique and characterization study was performed by using FTIR

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18

Zhang, Qian, Jiamin Huang, Chao Liu, et al. "Preparation of Ca-Mg Double-Doped Mesoporous Silica Nanoparticles and Their Drug-Loading and Drug-Releasing Properties." Inorganics 13, no. 1 (2025): 12. https://doi.org/10.3390/inorganics13010012.

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Breast cancer is a common clinical malignant tumor that seriously threatens women’s physical and mental health. Chemotherapy, as the first choice of breast cancer treatment, has limited its application in the clinic due to problems of poor stability, short half-life, and serious toxic side effects. With the emergence of nanotechnology, inorganic materials to prepare mesoporous silica nanoparticles (MSNs) have been widely used in anti-tumor drug carriers. However, their slow degradation rate limits their application in the biomedical field. Therefore, developing low-toxicity MSNs with good bioc

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19

Miraj, Shumaila, Hamid Saeed, Mehwish Iqtedar, et al. "Docetaxel-Loaded Methoxy poly(ethylene glycol)-poly (L-lactic Acid) Nanoparticles for Breast Cancer: Synthesis, Characterization, Method Validation, and Cytotoxicity." Pharmaceuticals 16, no. 11 (2023): 1600. http://dx.doi.org/10.3390/ph16111600.

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This study aimed to synthesize and characterize DTX-mPEG-PLA-NPs along with the development and validation of a simple, accurate, and reproducible method for the determination and quantification of DTX in mPEG-PLA-NPs. The prepared NPs were characterized using AFM, DLS, zetasizer, and drug release kinetic profiling. The RP-HPLC assay was developed for DTX detection. The cytotoxicity and anti-clonogenic effects were estimated using MTT and clonogenic assays, respectively, using both MCF-7 and MDA-MB-231 cell lines in a 2D and 3D culture system. The developed method showed a linear response, hig

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20

Gorgzadeh, Amirsasan, Ali Hheidari, Parizad Ghanbarikondori, et al. "Investigating the Properties and Cytotoxicity of Cisplatin-Loaded Nano-Polybutylcyanoacrylate on Breast Cancer Cells." Asian Pacific Journal of Cancer Biology 8, no. 4 (2023): 345–50. http://dx.doi.org/10.31557/apjcb.2023.8.4.345-350.

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Background: This study aimed to develop a novel drug formulation using polybutylcyanoacrylate (PBCA) nanoparticles to deliver cisplatin, a commonly used chemotherapeutic agent for breast cancer treatment.Materials and Methods: PBCA nanoparticles were synthesized using a mini-emulsion polymerization method, and the resulting NPs were comprehensively characterized for their physical properties, such as size, size distribution, zeta potential, drug loading, and encapsulation efficiency. In addition, the cytotoxicity of the NPs was assessed, along with their ability to release the entrapped drugs

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21

Gupta, Priya. "Abstract A031: Development of poly lactic acid based biodegradable nanoparticles for co-delivery of pirarubicin and gemcitabine for synergistic anti-tumor efficacy." Molecular Cancer Therapeutics 22, no. 12_Supplement (2023): A031. http://dx.doi.org/10.1158/1535-7163.targ-23-a031.

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Abstract Nanoparticles based drug delivery systems have provided a befitted solution for the poor pharmacokinetic properties and systemic toxicity caused by the chemo drugs because of their ability to improve bioavailability of the drugs at the desired site and thereby decreasing extracellular toxicity. The present work investigates the single or dual chemo drugs loaded PLA-based biodegradable polymeric nanoparticles for improved anti-tumor efficacy as compared to free drug formulations. For the study, an amphiphilic block copolymer; mPEG PLA has been synthesized and characterized using Gel pe

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Albasiony, Ahmed M., Amr M. Beltagi, Mohamed M. Ibrahim, Shaban Y. Shaban, and Rudi van Eldik. "GSH/pH-Responsive Chitosan–PLA Hybrid Nanosystems for Targeted Ledipasvir Delivery to HepG2 Cells: Controlled Release, Improved Selectivity, DNA Interaction, Electrochemical and Stopped-Flow Kinetics Analyses." International Journal of Molecular Sciences 26, no. 13 (2025): 6070. https://doi.org/10.3390/ijms26136070.

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This study aimed to design dual-responsive chitosan–polylactic acid nanosystems (PLA@CS NPs) for controlled and targeted ledipasvir (LED) delivery to HepG2 liver cancer cells, thereby reducing the systemic toxicity and improving the therapeutic selectivity. Two formulations were developed utilizing ionotropic gelation and w/o/w emulsion techniques: LED@CS NPs with a size of 143 nm, a zeta potential of +43.5 mV, and a loading capacity of 44.1%, and LED-PLA@CS NPs measuring 394 nm, with a zeta potential of +33.3 mV and a loading capacity of 89.3%, with the latter demonstrating significant drug p

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23

Lin, Jason, Chuanqi Peng, Sanjana Ravi, A. K. M. Nur Alam Siddiki, Jie Zheng, and Kenneth J. Balkus. "Biphenyl Wrinkled Mesoporous Silica Nanoparticles for pH-Responsive Doxorubicin Drug Delivery." Materials 13, no. 8 (2020): 1998. http://dx.doi.org/10.3390/ma13081998.

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Biphenyl wrinkled mesoporous silica nanoparticles with controlled particle size and high surface area were evaluated for the storage and delivery of doxorubicin. The average particle size and surface area were ~70 nm and ~1100 m2/g. The doxorubicin loading efficiency was 38.2 ± 1.5 (w/w)% and the release was pH dependent. The breast cancer cell line, MCF-7 (Michigan Cancer Foundation-7) was used for the in vitro drug release study. The cytotoxicity of doxorubicin-loaded nanoparticles was significantly higher than free doxorubicin. Fluorescence images showed biphenyl wrinkled mesoporous silica

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Yeganeh, Faten Eshrati, Amir Eshrati Yeganeh, Mohammad Yousefi, et al. "Formulation and Characterization of Poly (Ethylene Glycol)-Coated Core-Shell Methionine Magnetic Nanoparticles as a Carrier for Naproxen Delivery: Growth Inhibition of Cancer Cells." Cancers 14, no. 7 (2022): 1797. http://dx.doi.org/10.3390/cancers14071797.

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An efficient and selective drug delivery vehicle for cancer cells can remarkably improve therapeutic approaches. In this study, we focused on the synthesis and characterization of magnetic Ni1−xCoxFe2O4 nanoparticles (NPs) coated with two layers of methionine and polyethylene glycol to increase the loading capacity and lower toxicity to serve as an efficient drug carrier. Ni1−xCoxFe2O4@Methionine@PEG NPs were synthesized by a reflux method then characterized by FTIR, XRD, FESEM, TEM, and VSM. Naproxen was used as a model drug and its loading and release in the vehicles were evaluated. The resu

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25

Sahrayi, Hamidreza, Elham Hosseini, Sara Karimifard, et al. "Co-Delivery of Letrozole and Cyclophosphamide via Folic Acid-Decorated Nanoniosomes for Breast Cancer Therapy: Synergic Effect, Augmentation of Cytotoxicity, and Apoptosis Gene Expression." Pharmaceuticals 15, no. 1 (2021): 6. http://dx.doi.org/10.3390/ph15010006.

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Breast cancer is one of the most prevalent causes of cancer mortality in women. In order to increase patient prognosis and survival rates, new technologies are urgently required to deliver therapeutics in a more effective and efficient manner. Niosome nanoparticles have been recently employed as therapeutic platforms capable of loading and carrying drugs within their core for both mono and combination therapy. Here, niosome-based nanoscale carriers were investigated as a targeted delivery system for breast cancer therapy. The platform developed consists of niosomes loaded with letrozole and cy

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Nogueira, João, Sofia F. Soares, Carlos O. Amorim, et al. "Magnetic Driven Nanocarriers for pH-Responsive Doxorubicin Release in Cancer Therapy." Molecules 25, no. 2 (2020): 333. http://dx.doi.org/10.3390/molecules25020333.

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Doxorubicin is one of the most widely used anti-cancer drugs, but side effects and selectivity problems create a demand for alternative drug delivery systems. Herein we describe a hybrid magnetic nanomaterial as a pH-dependent doxorubicin release carrier. This nanocarrier comprises magnetic iron oxide cores with a diameter of 10 nm, enveloped in a hybrid material made of siliceous shells and ĸ-carrageenan. The hybrid shells possess high drug loading capacity and a favorable drug release profile, while the iron oxide cores allows easy manipulation via an external magnetic field. The pH responsi

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Thakur, Chanchal Kiran, Rabin Neupane, Chandrabose Karthikeyan, et al. "Lysinated Multiwalled Carbon Nanotubes with Carbohydrate Ligands as an Effective Nanocarrier for Targeted Doxorubicin Delivery to Breast Cancer Cells." Molecules 27, no. 21 (2022): 7461. http://dx.doi.org/10.3390/molecules27217461.

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Multiwalled carbon nanotubes (MWCNTs) are elongated, hollow cylindrical nanotubes made of sp2 carbon. MWCNTs have attracted significant attention in the area of drug delivery due to their high drug-loading capacity and large surface area. Furthermore, they can be linked to bioactive ligands molecules via covalent and noncovalent bonds that allow for the targeted delivery of anticancer drugs such as doxorubicin. The majority of methodologies reported for the functionalization of MWCNTs for drug delivery are quite complex and use expensive linkers and ligands. In the present study, we report a s

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28

Molina, Gustavo A., Alberto Elizalde-Mata, Ángel R. Hernández-Martínez, et al. "Synthesis and Characterization of Inulin-Based Responsive Polyurethanes for Breast Cancer Applications." Polymers 12, no. 4 (2020): 865. http://dx.doi.org/10.3390/polym12040865.

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In this study, new polyurethanes (PUs) were prepared by using inulin and polycaprolactone as polyols. Their structure and morphology were determined by Fourier transform infrared spectroscopy (FTIR), Raman dispersive spectroscopy, Nuclear magnetic resonance spectroscopy (1H NMR and 13C NMR), and scanning electron microscopy (SEM), whereas their mechanical properties were evaluated by a universal testing machine. Additionally, their water uptake, swelling behavior, and degradation were evaluated to be used as drug delivery carriers. Therefore, an anti-cancer drug was loaded to these PUs with 25

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Khathuriya, Rajesh, Shailesh Sharma, Upendra K. Jain, and Jitender Madan. "Formulation and Evaluation of Lycopene Nanoparticles for Breast Cancer." International Journal of Drug Delivery Technology 10, no. 02 (2020): 292–94. http://dx.doi.org/10.25258/ijddt.10.2.17.

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Aim: Lycopene is owned to carotenoids that manifest better pharmacological possessions such as antioxidant, anti-inflammatory, and anticancer. As an outcome of very little water solubility, it has a restricted systemic absorption after oral route. Methods: Lycopene-loaded sentinel lymph nodes (SLNs) by hot homogenization method, using some alteration were formulated. The size of nanoparticles (NPs) was characterized using scanning electron microscope (SEM). Also, encapsulation efficiency, drug loading (DL), and drug release were calculated. Results: SEM revealed spherical SLNs. High EE and DL

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30

Chen, Mengyi, Haifeng Wu, Haina Zhang, Jingjing Lin, Xuben Yu, and Qiaoqiao Xu. "Preparation, characterization and application of docetaxel-loaded methoxy polyethylene glycol-octacosanol micelles for breast cancer therapy." Materials Express 12, no. 4 (2022): 592–98. http://dx.doi.org/10.1166/mex.2022.2174.

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Objective: To prepare docetaxel (DOC)-loaded methoxy polyethylene glycol-octacosanol (MPEG2K-Oct) micelles and evaluate the in vitro and in vivo antitumor activity. Methods: DOC/MPEG-Oct was prepared using the thin-film hydration method. The physicochemical property including size, zeta potential and drug release behavior were studies. The in vitro cytotoxicity and the in vivo antitumor activity were evaluated. Results: The prepared DOC/MPEG-Oct micelles had a small size, as well as high drug loading capacity and encapsulation efficiency. These micelles also performed a sustained and controlla

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Nyankson, Emmanuel, Shadrack O. Aboagye, Johnson Kwame Efavi, et al. "Chitosan-Coated Halloysite Nanotubes As Vehicle for Controlled Drug Delivery to MCF-7 Cancer Cells In Vitro." Materials 14, no. 11 (2021): 2837. http://dx.doi.org/10.3390/ma14112837.

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The aim of the work is to improve the release properties of curcumin onto human breast cancer cell lines using coated halloysite nanotubes (HNTs) with chitosan as a polycation. A loading efficiency of 70.2% (w/w) was attained for loading 4.9 mg of the drug into 0.204 g bed volume of HNTs using the vacuum suction method. Results acquired from Brunauer-Emmett-Teller (BET), Fourier-transform infrared (FTIR) spectroscopy, transmission electron microscopy (TEM), scanning electron spectroscopy (SEM), zeta potential, and thermogravimetric analysis (TGA) indicated the presence of the drug and the biop

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32

Rahmani, Hamid, Ali Fattahi, Komail Sadrjavadi, Salar Khaledian, and Yalda Shokoohinia. "Preparation and Characterization of Silk Fibroin Nanoparticles as a Potential Drug Delivery System for 5-Fluorouracil." Advanced Pharmaceutical Bulletin 9, no. 4 (2019): 601–8. http://dx.doi.org/10.15171/apb.2019.069.

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Purpose: The aim of this study is to prepare 5-fluorouracil (5-FU) loaded silk fibroin nanoparticles(SFNPs) and to achieve a controlled release delivery system with the high loading capacity. Methods: SFNPs with 1:1, 1:3, and 1:10 ratios of 5-FU to silk fibroin were prepared. SFNPswere characterized by Fourier-transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD)analysis, Scanning electron microscope (SEM), and Transmission electron microscope (TEM).Loading efficiency, in vitro release, and cell viability were studied for optimal SFNPs. Results: The ratio of 1:1 was optimal formulat

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Snehalatha, G., and Shailaja Pashikanti. "Enhanced Breast Cancer Treatment Using Orlistat-Loaded Lipid-Polymer Hybrid Nanoparticles: Formulation, Characterization and Evaluation." Journal of Neonatal Surgery 14, no. 7S (2025): 746–59. https://doi.org/10.52783/jns.v14.2493.

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Breast cancer continues to be a significant global health concern, prompting the development of advanced drug delivery systems to improve therapeutic effectiveness and minimize adverse effects. Lipid-polymer hybrid nanoparticles (LPHNPs) offer a promising approach by combining the benefits of both liposomes and polymeric nanoparticles, thereby improving drug solubility, bioavailability, and controlled release. This study aimed to develop and optimize Orlistat-loaded LPHNPs (ORL-LPHNPs) using soya lecithin, Eudragit RLPO, and Tween 80 via nanoprecipitation. Various formulations (LPHNP1-LPHNP8)

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Ahmed, Mohammed Muqtader, Farhat Fatima, Amer Alali, et al. "Ribociclib-Loaded Ethylcellulose-Based Nanosponges: Formulation, Physicochemical Characterization, and Cytotoxic Potential against Breast Cancer." Adsorption Science & Technology 2022 (March 14, 2022): 1–11. http://dx.doi.org/10.1155/2022/1922263.

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In the present study, ribociclib-loaded nanosponges (RCNs) composed of ethylcellulose and polyvinyl alcohol were developed using an emulsion-solvent evaporation method. Preliminary evaluations of the developed RCNs (RCN1 to RCN7) were performed in terms of size, polydispersity index (PDI), zeta potential (ZP), entrapment efficiency (EE), and drug loading (DL), which allowed us to select the optimized formulation. RCN3 was selected as the optimized carrier system with particle size ( 363.5 ± 4.8 nm ), PDI ( 0.292 ± 0.012 ), zeta potential ( − 18.5 ± 0.05 mV ), EE ( 81.35 ± 1.64 % ), and DL ( 21

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Gupta, Priya, Surender M. Kharbanda, and Harpal Singh. "Abstract 5817: pH responsive delivery of gemcitabine/pirarubicin co-loaded biodegradable polymeric nanoparticles for synergistic anti-cancer therapy." Cancer Research 84, no. 6_Supplement (2024): 5817. http://dx.doi.org/10.1158/1538-7445.am2024-5817.

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Abstract Gemcitabine, a nucleoside antimetabolite, is a widely known chemotherapeutic agent being used as a first line treatment alone or in combination with other chemo drugs for different types of cancer. However, due to its extremely short half-life in the body caused by enzymatic degradation and poor pharmacokinetics, the I.V. dosage of administration is quite high i.e., &gt;1000 mg/m2 for metastatic breast cancer treatment. Moreover, gemcitabine in combination with anthracyclines imparts synergy but free anthracyclines are reported to be associated with long term cardiac toxicity. Nan

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Mohammadinezhad, Fateme, Armin Talebi, Mohammadreza Allahyartorkaman, Reza Nahavandi, Maryam Vesal, and Azim Akbarzadeh Khiyavi. "Preparation, Characterization and Cytotoxic Studies of Cisplatin-containing Nanoliposomes on Breast Cancer Cell Lines." Asian Pacific Journal of Cancer Biology 8, no. 2 (2023): 155–59. http://dx.doi.org/10.31557/apjcb.2023.8.2.155-159.

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Objective: Today, cancer is one the most important challenges in modern medicine. Breast carcinoma is one type of cancer that is treated with cisplatin, a chemotherapy drug. By using liposomal nanocarriers, this study seeks to increase the therapeutic efficiency of cisplatin. Method: The zeta potential, particle size, and drug-release characteristics of nanoliposomal cisplatin were evaluated after it had been synthesized using the reverse phase evaporation technique. The cytotoxicity rate of nanoliposomal cisplatin was then assessed using the T-47D breast cancer cell line. Results: This study’

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García-García, Gracia, Fátima Fernández-Álvarez, Laura Cabeza та ін. "Gemcitabine-Loaded Magnetically Responsive Poly(ε-caprolactone) Nanoparticles against Breast Cancer". Polymers 12, № 12 (2020): 2790. http://dx.doi.org/10.3390/polym12122790.

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A reproducible and efficient interfacial polymer disposition method has been used to formulate magnetite/poly(ε-caprolactone) (core/shell) nanoparticles (average size ≈ 125 nm, production performance ≈ 90%). To demonstrate that the iron oxide nuclei were satisfactorily embedded within the polymeric solid matrix, a complete analysis of these nanocomposites by, e.g., electron microscopy visualizations, energy dispersive X-ray spectroscopy, Fourier-transform infrared spectroscopy, electrophoresis, and contact angle goniometry was conducted. The magnetic responsive behaviour of these nanoparticles

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Ponraj, T., and S. Kannan. "Mitochondrial Dysfunction–Induced Apoptosis in Breast Carcinoma Cells Through pH-Dependent Intracellular Quercetin NDDS of PVPylated-TiO2NPs." Journal of Global Oncology 4, Supplement 2 (2018): 215s. http://dx.doi.org/10.1200/jgo.18.86800.

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Background: The conventional chemotherapy has some noticeable drawbacks, such as lack of specificity, the requirement of high drug-dose, adverse effects, and gradual development of multidrug resistance (MDR), that reduce the efficacy of cancer therapy. Aim: To achieve intracellular drug delivery, strategies for overcoming various biologic barriers from the system level to the organ level, to the cellular level. To win through over these challenges in chemotherapy is to be achieving high drug loading combination with low leakage at physiologic pH, minimal toxicity toward healthy cells, and tuna

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Ridha, Abbas A., Soheila Kashanian, Abbas H. Azandaryani, Ronak Rafipour, and Elahe Mahdavian. "New Folate-Modified Human Serum Albumin Conjugated to Cationic Lipid Carriers for Dual Targeting of Mitoxantrone against Breast Cancer." Current Pharmaceutical Biotechnology 21, no. 4 (2020): 305–15. http://dx.doi.org/10.2174/1389201020666191114113022.

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Aim: In the present work, folic acid-modified human serum albumin conjugated to cationic solid lipid nanoparticles were synthesized as nanocarriers of mitoxantrone for the treatment of breast cancer. Background: Dual-targeted drug delivery is a new drug dosing strategy that is frequently used to enhance the therapeutic efficacy of anticancer drugs. Objective: Dual targeting of the cancer cells was achieved by dual tagging of human serum albumin and folic acid on the surface of the lipid nanoparticles. Methods: The targeted drug-loaded nanocomplexes were synthesized and characterized using tran

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Hamidia, Zahra, Kahin Shahanipour, Nasrin Talebian, and Ramesh Monajemi. "Preparation of chelidonine highly loaded poly(lactide-co-glycolide)-based nanoparticles using a single emulsion method: Cytotoxic effect on MDA-MB-231 cell line." Journal of Herbmed Pharmacology 11, no. 1 (2021): 114–20. http://dx.doi.org/10.34172/jhp.2022.13.

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Introduction: Chelidonine, a bio-active component of Chelidonium majus, has been investigated for its anti-proliferative effects on various cancer cell lines with multidrug resistance (MDR). Although the results are auspicious, its poor water solubility and low bioavailability are the main limitations for clinical applications. This study aimed to develop poly(lactic-co-glycolic acid) (PLGA) nanoparticles loaded with chelidonine, in order to enhance its bioavailability for oral administration and improve the therapeutic index. Methods: Herein, we encapsulated chelidonine in PLGA nanoparticles

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Dave, Pooja, and Chetan Detroja. "Formulation and Characterization of Raloxifene loaded Biodegradable Polymeric Nanomicelles." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 13, no. 01 (2023): 158–61. http://dx.doi.org/10.25258/ijddt.13.1.24.

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Raloxifene has been used to treat breast cancer; nevertheless, it has poor water solubility and a low bioavailability fraction because higher fi rst-pass metabolism hinders its application raloxifene nano micelles by using PLGA50:50 to enhance solubility and bioavailability. The solvent evaporation technique was used to prepare polymeric nano-micelles. Ral-loaded polymeric micelles had a zeta potential of - 0.71 mV, implying a practically neutral surface charge. Blank micelles and RAL-loaded micelles had similar average sizes of 84.29 nm and 95.41 nm, respectively. The drug encapsulating and d

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García, Mónica C., Nabila Naitlho, José Manuel Calderón-Montaño, et al. "Cholesterol Levels Affect the Performance of AuNPs-Decorated Thermo-Sensitive Liposomes as Nanocarriers for Controlled Doxorubicin Delivery." Pharmaceutics 13, no. 7 (2021): 973. http://dx.doi.org/10.3390/pharmaceutics13070973.

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Stimulus-responsive liposomes (L) for triggering drug release to the target site are particularly useful in cancer therapy. This research was focused on the evaluation of the effects of cholesterol levels in the performance of gold nanoparticles (AuNPs)-functionalized L for controlled doxorubicin (D) delivery. Their interfacial and morphological properties, drug release behavior against temperature changes and cytotoxic activity against breast and ovarian cancer cells were studied. Langmuir isotherms were performed to identify the most stable combination of lipid components. Two mole fractions

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Villetti, Marcos Antonio, Adryana Rocha Clementino, Ilaria Dotti, et al. "Design and Characterization of Maltoheptaose-b-Polystyrene Nanoparticles, as a Potential New Nanocarrier for Oral Delivery of Tamoxifen." Molecules 26, no. 21 (2021): 6507. http://dx.doi.org/10.3390/molecules26216507.

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Tamoxifen citrate (TMC), a non-steroidal antiestrogen drug used for the treatment of breast cancer, was loaded in a block copolymer of maltoheptaose-b-polystyrene (MH-b-PS) nanoparticles, a potential drug delivery system to optimize oral chemotherapy. The nanoparticles were obtained from self-assembly of MH-b-PS using the standard and reverse nanoprecipitation methods. The MH-b-PS@TMC nanoparticles were characterized by their physicochemical properties, morphology, drug loading and encapsulation efficiency, and release kinetic profile in simulated intestinal fluid (pH 7.4). Finally, their cyto

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Vazda, Amina, Michael Pujari-Palmer, Wei Xia, and Håkan Engqvist. "Entrapment of a Cytotoxic Drug into the Crystal Structure of Calcite for Targeted Drug Delivery." Materials 14, no. 22 (2021): 6735. http://dx.doi.org/10.3390/ma14226735.

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Controlled drug release and targeted drug delivery can reduce systemic toxicity of chemotherapeutics by restricting drugs to the target organ and increasing the local concentration. As tumors and inflamed tissue are often surrounded by an acidic microenvironment, pH-responsive calcium carbonates (CaCO3) are promising vehicles for controlled drug delivery applications. The aim of this study was to evaluate the loading efficacy and release of a chemotherapeutic drug, Hydroxyurea (HU), into the crystal structure of calcite. Incorporation of HU did not alter the crystallinity, crystal size, or mor

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Yu, Cunguo, Lixin Zhang, Jinying Liu, and Xiaoguang Wang. "Evaluation of infrared thermography combined with drug-loaded superparamagnetic nanoparticles for the diagnosis and treatment of breast cancer." Materials Express 11, no. 1 (2021): 9–15. http://dx.doi.org/10.1166/mex.2021.1881.

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Breast cancer (BC) is a common malignant tumor that threatens both the physical and mental health of women worldwide, the incidence of BC is increasing each year. Early detection and prompt diagnosis are key for prevention of BC and will promote reductions in morbidity and mortality. As such, we present here an integrated diagnostic and treatment strategy for BC that is based on infrared thermal imaging (IRTI) combined with superparamagnetic iron tetroxide (Fe3O4) nanoparticles. In this work, a doxorubicin (DOX) anticancer drug platform was generated using polyethylene-coated paramagnetic nano

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Rani, Ruma, Parth Malik, Sunena Dhania, and Tapan Kumar Mukherjee. "Recent Advances in Mesoporous Silica Nanoparticle-Mediated Drug Delivery for Breast Cancer Treatment." Pharmaceutics 15, no. 1 (2023): 227. http://dx.doi.org/10.3390/pharmaceutics15010227.

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Breast cancer (BC) currently occupies the second rank in cancer-related global female deaths. Although consistent awareness and improved diagnosis have reduced mortality in recent years, late diagnosis and resistant response still limit the therapeutic efficacy of chemotherapeutic drugs (CDs), leading to relapse with consequent invasion and metastasis. Treatment with CDs is indeed well-versed but it is badly curtailed with accompanying side effects and inadequacies of site-specific drug delivery. As a result, drug carriers ensuring stealth delivery and sustained drug release with improved phar

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Al-Busaidi, Hamed, Md Karim, Syafiq Abidin, Kyi Tha, and Ezharul Chowdhury. "Magnesium Fluoride Forms Unique Protein Corona for Efficient Delivery of Doxorubicin into Breast Cancer Cells." Toxics 7, no. 1 (2019): 10. http://dx.doi.org/10.3390/toxics7010010.

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Background: The efficacy of chemotherapy is undermined by adverse side effects and chemoresistance of target tissues. Developing a drug delivery system can reduce off-target side effects and increase the efficacy of drugs by increasing their accumulation in target tissues. Inorganic salts have several advantages over other drug delivery vectors in that they are non-carcinogenic and less immunogenic than viral vectors and have a higher loading capacity and better controlled release than lipid and polymer vectors. Methods: MgF2 crystals were fabricated by mixing 20 mM MgCl2 and 10 mM NaF and inc

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Pinzón-García, Ana D., Ruben Sinisterra, Maria Cortes, Fredy Mesa, and Sandra Ramírez-Clavijo. "Polycaprolactone nanofibers as an adjuvant strategy for Tamoxifen release and their cytotoxicity on breast cancer cells." PeerJ 9 (October 27, 2021): e12124. http://dx.doi.org/10.7717/peerj.12124.

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Breast cancer is the second leading cause of death in women, and tamoxifen citrate (TMX) is accepted widely for the treatment of hormone receptor–positive breast cancers. Several local drug-delivery systems, including nanofibers, have been developed for antitumor treatment. Nanofibers are biomaterials that mimic the natural extracellular matrix, and they have been used as controlled release devices because they enable highly efficient drug loading. The purpose of the present study was to develop polycaprolactone (PCL) nanofibers incorporating TMX for use in the treatment of breast tumors. Pris

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Rostami, Neda, Farzaneh Faridghiasi, Aida Ghebleh, et al. "Design, Synthesis, and Comparison of PLA-PEG-PLA and PEG-PLA-PEG Copolymers for Curcumin Delivery to Cancer Cells." Polymers 15, no. 14 (2023): 3133. http://dx.doi.org/10.3390/polym15143133.

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Curcumin (CUR) has potent anticancer activities, and its bioformulations, including biodegradable polymers, are increasingly able to improve CUR’s solubility, stability, and delivery to cancer cells. In this study, copolymers comprising poly (L-lactide)-poly (ethylene glycol)-poly (L-lactide) (PLA-PEG-PLA) and poly (ethylene glycol)-poly (L-lactide)-poly (ethylene glycol) (PEG-PLA-PEG) were designed and synthesized to assess and compare their CUR-delivery capacity and inhibitory potency on MCF-7 breast cancer cells. Molecular dynamics simulations and free energy analysis indicated that PLA-PEG

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Kotta, Sabna, Hibah Mubarak Aldawsari, Shaimaa M. Badr-Eldin, Anroop B. Nair, Mohammed Kaleem, and Mahmood Hassan Dalhat. "Thermosensitive Hydrogels Loaded with Resveratrol Nanoemulsion: Formulation Optimization by Central Composite Design and Evaluation in MCF-7 Human Breast Cancer Cell Lines." Gels 8, no. 7 (2022): 450. http://dx.doi.org/10.3390/gels8070450.

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The second most common cause of mortality among women is breast cancer. A variety of natural compounds have been demonstrated to be beneficial in the management of various malignancies. Resveratrol is a promising anticancer polyphenolic compound found in grapes, berries, etc. Nevertheless, its low solubility, and hence its low bioavailability, restrict its therapeutic potential. Therefore, in our study, we developed a thermosensitive hydrogel formulation loaded with resveratrol nanoemulsion to enhance its bioavailability. Initially, resveratrol nanoemulsions were formulated and optimized utili

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