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1

Agenbag, Gloudi. "Molecular genetic analysis of familial breast cancer in South Africa." Thesis, Link to the online version, 2005. http://hdl.handle.net/10019/953.

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2

Kramer, Nicole. "Prevalence of shoulder morbidity after treatment for breast cancer in South Africa." Master's thesis, University of Cape Town, 2018. http://hdl.handle.net/11427/27973.

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Introduction: Breast cancer is the most frequently diagnosed cancer and leading cause of cancer death among women and represents a considerable public health burden in South Africa and other low-middle income countries. Breast cancer management comprises single or combination treatment including surgery, radiotherapy and chemotherapy. Short and long-term complications of these treatments include shoulder morbidities such as pain, decreased range of motion, tightness, weakness, pain, numbness and lymphoedema, and may be present for up to 6 years post-surgery. An understanding of baseline demogr
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3

Daries, Valdiela. "The profile of breast cancer among patients attending a Breast Clinic in Cape Town, South Africa." Master's thesis, University of Cape Town, 2013. http://hdl.handle.net/11427/6033.

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Includes abstract.<br>Includes bibliographical references.<br>Breast cancer is the leading cancer among women in South Africa (SA). Studies conducted in developing countries have shown that the majority of women present with advanced stage breast cancer at diagnosis. There is a gap in terms of recent data on the profile of breast cancer patients in SA. The purpose of the study was to obtain recent data with regards to the sociodemographic, clinical and risk factor profile of breast cancer in patients who presented at a Breast Clinic linked to a tertiary public hospital in the Western Cape in o
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4

Scullard, Nicole. "Subjective lived experiences of women with early stage breast cancer in Cape Town." University of the Western Cape, 2015. http://hdl.handle.net/11394/5081.

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Magister Artium - MA<br>Breast cancer is a common cause of death among women worldwide. It has long been recognized as a major public health burden in high-income countries, however, the majority of cases are said to occur in low and middle-income countries, such as in South Africa. A breast cancer diagnosis and treatment heralds a series of frightening events and can be a traumatic experience. The manner in which women perceive and cope with their illness is predictive of emotional and physical health outcomes. It is thus imperative to explore the experiences of South African women, whose voi
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5

Sunkara, Ranga Rao. "Comparative study of breast cancer in the United States, India, and South Africa: 1996- present." DigitalCommons@Robert W. Woodruff Library, Atlanta University Center, 2001. http://digitalcommons.auctr.edu/dissertations/1693.

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This study identifies forces that prevent or contribute to women's participation in breast cancer screening and other breast cancer prevention activities. The study was based on the premise that women from the lower socioeconomic groups in India, South Africa, and the United States had a higher rate of breast cancer because they are diagnosed at the more advanced stages of the disease and do not engage in breast screening opportunities. Moreover, there is limited access to services and transportation, and there is little faith in the professional health care provider and the treatment received
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6

Ng'ang'a, Mukuhi. "Delay in provision of breast cancer care in patients seen at a district hospital diagnostic breast unit in South Africa." Master's thesis, University of Cape Town, 2018. http://hdl.handle.net/11427/28069.

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Background: There is evidence to show that delays in breast cancer management are detrimental to patient outcome. The aim of this study was to determine time trends and causes of delay in a newly established diagnostic breast clinic based at a district hospital in South Africa. Method: All patients who presented to Mitchells Plain District Hospital Breast Clinic from January to December 2015 and had a diagnosis of breast cancer were included in this study. The intervals between the time she first noted her symptoms to initial contact with a health professional and delivery of definitive therap
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7

Kamanga, Thembekile Nokukhanya. "A microsociological analysis of social support to women diagnosed with early stage breast cancer." Thesis, University of the Western Cape, 2016. http://hdl.handle.net/11394/5536.

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Magister Artium - MA<br>This study explored the social support provided by family of women diagnosed with early stage breast cancer. The aim was to present an account of social support that is solicited by and given to women diagnosed with early stage breast cancer. There is a dearth amount of literature on support from families of women with breast cancer in South Africa. Thus, this study can potentially contribute to filling the gap of knowledge in this area in the country. Qualitative method was used and in-depth interviews were utilized to study the women's experience of family social supp
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8

Hassan, Mohammed Hashim Abdalraheem. "Characterization of ATP-binding cassette drug transporters and their role in breast cancer treatment using in silico approach." University of the Western Cape, 2019. http://hdl.handle.net/11394/7255.

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>Magister Scientiae - MSc<br>Breast cancer is the most common cancer in women worldwide, and is the second most common cancer in the world, responsible for more than 500 000 deaths annually. Estimates are that 1 in 8 women will develop breast cancer in their lifetime. In South Africa, breast cancer in women affects about 16.6 % of the population and could see a 78 % increase in cases by 2030. Comprehensive therapy on breast cancer including surgical operation, chemotherapy, radiotherapy, endocrinotherapy, etc. could help, but still has serious side effects. The Chemotherapy resistance against
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9

Winchester, Carolyn Margaret. "Anti-p53 and c-erbB2 as prognostic markers in South African breast cancer patients." Thesis, Cape Technikon, 2000. http://hdl.handle.net/20.500.11838/1518.

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Thesis (DTech(Biomedical Technology))--Cape Technikon, Cape Town, 2000<br>The diagnosis of breast cancer is not possible using currently available serological detection of cancer markers as these lack adequate sensitivity or specificity. This study investigates the prevalence and significance of anti-p53 antibody and c-erbB-2 protein in the post-surgical sera of South African breast cancer patients and correlates these features with the clinicopathological characteristics of breast cancer. Further, this study investigates the possibilityofimproving prognostic sensitivityby combining
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10

Mentoor, J. L. D. (Juliet Lewie Dionee). "Identification of rare gene variants in South African breast cancer families through next generation sequencing." Thesis, University of Pretoria, 2017. http://hdl.handle.net/2263/63043.

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Breast cancer (BC) has become the leading cancer amongst women in South Africa. The overall life time risk for developing this disease is one in 12 (National Cancer registry, 2000- 2011). A strong family history (≥3 affected) is an important factor for inherited predisposition to BC that accounts for approximately 10% of cases worldwide. Mutations in several high- and moderate risk breast cancer genes have been associated with familial BC and includes BRCA1, BRCA2, TP53, PALB2, and CHEK2. Individuals that carry germline mutations in BRCA1 and BRCA2 possess an 80% lifetime risk for BC. Mu
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11

Gerber, Jaclyn. "Cytochrome P450 polymorphisms : relevance in two South African disease populations." Thesis, Stellenbosch : Stellenbosch University, 2003. http://hdl.handle.net/10019.1/53345.

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Thesis (MSc)--Stellenbosch University, 2003.<br>ENGLISH ABSTRACT: With knowledge of the human genome increasing constantly we are continually faced with new and potentially groundbreaking methods for managing, treating and/or identifying diseases and predisposition to diseases and conditions at a genetic level. The human cytochrome P450 (CYP) super-family of genes code for enzymes that can participate in metabolism of drugs and foreign chemicals and in steroid synthesis and metabolism. Mutations in these genes may contribute to clinically relevant diseases. In this study, the effects of
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12

Araujo, Monica Rodrigues. "Perspectives and Experiences of Individuals Undergoing Predictive Testing for Hereditary Breast and Ovarian Cancer (HBOC) Syndrome in the Western Cape, South Africa." Master's thesis, Faculty of Health Sciences, 2018. http://hdl.handle.net/11427/30057.

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Breast cancer is the most common malignancy affecting females globally. Hereditary breast and ovarian cancer (HBOC) syndrome is caused by pathogenic variants in BRCA1 and BRCA2 and is seen in approximately 50% of families with a strong history of breast and ovarian cancers. Predictive testing (PT) is offered to unaffected individuals with a positive family history of HBOC, with an already identified BRCA1 or BRCA2 mutation in an affected family member. There is an overwhelming amount of research that has focused on the after-effects of diagnostic genetic testing for HBOC but there has been lit
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13

Chilwesa, Paul Mambwe. "Comparison of 18F-Fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (18F-FDG PET/CT) and conventional imaging (CI) for locally advanced breast cancer staging: a prospective study from a tertiary hospital cancer centre in Western Cape." Master's thesis, Faculty of Health Sciences, 2019. http://hdl.handle.net/11427/31433.

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Background: Breast cancer is the second most common cancer in adults and the most frequent cancer diagnosed in women. In South Africa, breast cancer accounts for 38.5% of cancers diagnosed in women. Since the presence, extent and location of distant metastases is one important prognostic factor in locally advanced breast cancer (LABC), accurate staging at diagnosis is crucial to ensure patients receive the appropriate treatment. Increasing evidence shows that the use of 18F-FDG PET/CT for disease staging of LABC may improve diagnostic sensitivity. Aim: To prospectively assess the difference
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14

Grant, Kathleen Ann. "Analysis of the clinical utility of gene expression profiling in relation to conventional prognostic markers in South African patients with breast carcinoma." Thesis, Stellenbosch : Stellenbosch University, 2014. http://hdl.handle.net/10019.1/95824.

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Thesis (PhD)--Stellenbosch University, 2014.<br>ENGLISH ABSTRACT: Breast cancer is a heterogeneous disease characterised by marked inter-individual variability in presentation, prognosis and clinical outcome. The recognition that morphological assessment has limited utility in stratifying patients into prognostic subgroups led to clinico-pathological classification of tumour biology, based on receptor expression using immunohistochemical (IHC) techniques. This standard is currently complemented by the development of gene expression profiling methodology that led to the identification of intrin
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15

Van, der Walt Jacobus Gert. "Radiation field shaping through low temperature thermal-spray in radiotheraphy." Thesis, Bloemfontein : Central University of Technology, Free State, 2009. http://hdl.handle.net/11462/116.

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Thesis (D. Tech.) -- Central University of Technology, Free State, 2009<br>Superficial cancerous lesions are commonly treated through low energy X-ray or electron radiation in radiotherapy. The treatment units that produce the radiation are equipped with square, rectangular and round applicators of different sizes. These applicators attach to the treatment units and define the radiation field size applied during treatment. An applicator is chosen to fit the shape of the cancerous lesion on the patient as closely as possible. Since cancerous lesions are irregular in shape, there will always be
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16

Abulkasim, Muna Abdussalam Owen. "The prevalence of breast cancer in Africa and establishment of The Libyan Breast Cancer Registry." Master's thesis, Faculty of Health Sciences, 2020. http://hdl.handle.net/11427/32180.

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Breast cancer is well-known globally and remains one of the principal health concerns affecting women, and a rare malignancy in men. Although, there has been significant progress made in prevention strategies such as early detection and better treatment in most developed countries, incidence and mortality rates of breast cancer continued to rise. The rise is significant in Africa, a continent low in resources with a growing and ageing population exposed to risk factors leading to developing the disease. Although the incidence of breast cancer is lower in Africa than in high-income countries, m
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17

Jedy-Agba, E. "Breast cancer in sub-Saharan Africa : determinants of stage at diagnosis and diagnostic delays in women with symptomatic breast cancer." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2017. http://researchonline.lshtm.ac.uk/3928323/.

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Background: Breast cancer is the most common female cancer worldwide and in sub-Saharan Africa (SSA). Breast cancer incidence in SSA is relatively low but, as survival from the disease in the region is poor, mortality rates are as high as in high income countries. Late stage at diagnosis, and delays in a woman’s journey to a cancer diagnosis, are features known to contribute to poor breast cancer survival rates. There has been little focus on the factors affecting stage at diagnosis and the determinants of diagnostic delays in SSA despite previous studies highlighting the importance of early d
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18

Ndui, Mary K. "Epidemiology of oral cancer in South Africa 1996-2002." Thesis, University of the Western Cape, 2011. http://etd.uwc.ac.za/index.php?module=etd&action=viewtitle&id=gen8Srv25Nme4_8665_1367481245.

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<p>Oral cancer is characterised by marked geographical differences in frequency and site preference as reported by various studies. In South Africa, a few studies have been reported on the patterns and aetiology of oral cancer, and age standardised incidence rates (ASIR). Studies in several countries have shown an increase in oral cancer incidence among younger people. Title:&nbsp<br>Epidemiology of oral cancer in South Africa 1996-2002.&nbsp<br>Aim and Objective: The aim of this study was to determine the age standardised incidence rates (ASIR) of oral cancer by age, gender, race&nbsp<br>and
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19

Opoku, Samuel Yaw. "Knowledge, attitudes, beliefs, behaviour and breast cancer screening practices in Ghana, West Africa." Thesis, City University London, 2007. http://openaccess.city.ac.uk/8570/.

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Breast cancer is both the most common cancer and the leading cause of cancer related death among women around the world. The incidence of the disease is generally considered higher among women in the developed countries than the developing countries; however, the mortality rates for women in the developing countries meet or exceed those of the developed world, indicating poorer prognosis (Pannuti et al., 2000; WHO, 2000; IARC, 2001; IARC, 2002; Anderson et al., 2003; Tannerberger et al., 2004). Ghanaian women, like many other women from the developing countries, have a low participation rate i
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20

Amer, Akrem. "Epidemiology and Anatomic Distribution of Colorectal Cancer in South Africa." Master's thesis, Faculty of Health Sciences, 2021. http://hdl.handle.net/11427/33624.

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Background: Colorectal cancer (CRC) is the 5th most common cancer in subSaharan Africa (SSA) and the 3rd most common cancer in Southern Africa. CRC characteristics in SSA, including anatomic distribution, are not well described. Objective: To describe patient characteristics and anatomic location of colorectal adenocarcinoma (CRC-AC) in South Africa. Design: This was a retrospective study of CRC using the South African National Cancer Registry from 2006-2011. Main Outcome Measures: Patient age, gender, racial/ethnic group, province, histology type, and tumour location. Results: 6146 patients w
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21

Moodley, Jennifer Rose. "Prevention of cervical cancer in South Africa : opportunities and challenges." Doctoral thesis, University of Cape Town, 2011. http://hdl.handle.net/11427/10990.

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22

Sagoo, Parminder. "Experiences of South Asian women with breast cancer : coping via 'strength through connection'." Thesis, University of East London, 2010. http://roar.uel.ac.uk/1882/.

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The aim of this qualitative study was to gain a better understanding of how British South Asian women cope with breast cancer. The NICE (2004) Guidance suggests that appropriate psychological support should be available for all patients through all stages of their treatment from diagnosis to end-of-life. A literature review indicated a paucity of UK based studies on which to base practice. In order to understand the coping experience of this group, ten female South Asian patients being treated for breast cancer were recruited for in-depth semi-structured interviews, which were recorded and tra
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Cheok, Frida. "Participation in mammographic screenings in South Australia /." Title page, contents and abstract only, 1998. http://web4.library.adelaide.edu.au/theses/09PH/09phc51843.pdf.

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24

Ngugi, Pearl. "Response and adherence of HIV positive women to cervical cancer treatment." Thesis, Nelson Mandela Metropolitan University, 2011. http://hdl.handle.net/10948/d1014129.

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It is estimated that 6742 South African women are diagnosed with cervical cancer and 3681 women die from the disease every year. In 1993, The Centers for Disease Control declared cervical cancer an Acquired Immunodeficiency Syndrome defining illness. Apart from persistent human papillomavirus infection, HIV infection is the most common co-factor contributing to cervical cancer in South Africa. Studies have noted that in HIV positive women, there has been an occurrence of faster progression to more advanced stages of cervical cancer with high cases of treatment failure and recurrence. There is
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Patel, Geeta. "The psychosocial impact of breast cancer diagnosis and treatment in Black and South Asian women." Thesis, University of the West of England, Bristol, 2013. http://eprints.uwe.ac.uk/20099/.

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Breast cancer is the most common form of cancer in women of all ethnic groups. The diagnosis and treatment of the disease can be challenging and distressing for any individual. Research in this area has documented a range of physical, psychological and social consequences. However, very little work within the existing literature captures the experiences of Black and Minority Ethnic (BME) women, especially in the UK. The limited available research, based on American studies, show that while similarities in White and BME women’s breast cancer experiences exist, there are also aspects that are un
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26

Felix, Rebecca. "The molecular genetic and epidemiological investigation of colorectal cancer in South Africa." Doctoral thesis, University of Cape Town, 2003. http://hdl.handle.net/11427/3093.

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Bibliography: leaves 161-191.<br>Cancer of the colon and rectum is the third-most common cause of death due to neoplasia in Western countries. Colorectal cancer (CRC) can broadly be divided into the hereditary, non-hereditary and sporadic forms. Hereditary cancers account for approximately 10% of the CRCs. Familial cancers can be divided into thos types in which polyps are a dominant feature (e.g. familal adenomatous polyposis-FAP) and the non-polypotic forms (e.g. hereditary nonpolyposis colorectal cancers-HNPCC).
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Tailor, Bharti. "The experiences of South Asian women with breast cancer and the complexities of whole person care." Thesis, University of Southampton, 2008. https://eprints.soton.ac.uk/71891/.

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This study investigates the experiences of South Asian women being treated for breast cancer within a British system of health and social care that recognises racialised inequalities in care and is striving to provide culturally sensitive care to an increasingly diverse population. The research was conducted in a National Health Service (NHS) Trust in an outer London suburb. It is a qualitative exploratory study based on eighteen in- depth interviews and participant observation of interactions between women with breast cancer and health care professionals. The interviews were conducted in thre
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Hanson, Victoria Funmilayo. "An empowerment programme for women on breast self-examination towards the prevention of breast cancer in Iddo Local Government, Oyo State, South-west Nigeria." University of the Western Cape, 2015. http://hdl.handle.net/11394/4682.

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Philosophiae Doctor - PhD<br>Cancer is a major public health concern in both developed and developing countries; it accounts for 13% of all deaths globally, of which 70% occur in middle- and low-income countries. In Nigeria, over 10 000 cancer deaths and 250 000 new cases of cancer are recorded yearly. Breast cancer is the second most common cancer worldwide, after lung cancer. It is the most common type of cancer diagnosed in women and the most common cause of death worldwide. Late detection and diagnosis of breast cancer leads to high mortality rate. In Nigeria certain cultural taboos are as
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Sewram, Vikash. "Risk factors for oesophageal cancer in the Eastern Cape Province of South Africa." Doctoral thesis, University of Cape Town, 2006. http://hdl.handle.net/11427/9335.

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Includes bibliographical references (p. 196-245).<br>A multicenter hospital-based case-control study with incidence density sampling was conducted between November 2001 and February 2003 to assess the impact of social and dietary habits, and the consumption of dietary and medicinal wild plants on the risk of developing oesophageal cancer (OC) among residents of the Eastern Cape Province of South Africa. The study was conducted on 670 incident cases (98/% response rate) and 1188 controls (96/% response rate) attending either of the three major referral hospitals in the Province, i.e Umtata Gene
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Essack, Magbubah. "Screening extracts of indigenous South African plants for the presence of anti-cancer compounds." Thesis, University of the Western Cape, 2006. http://etd.uwc.ac.za/index.php?module=etd&action=viewtitle&id=gen8Srv25Nme4_8767_1210844967.

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<p>Early man dabbled with the use of plant extracts to cure ailments. This practice has been passed down from generation to generation and today more than 50% of the world'sdrugs are natural products or derivatives thereof. Scientists have thus established a branch of research called natural product research. This branch of research involves the identification and purification of secondary metabolites with a specific biological activity. The methodology involves the screening of plant products for a specific biological activity, purification of the biologically active natural product by separa
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31

Habib, Sanzida Zohra. "South Asian immigrant women’s access to and experiences with breast and cervical cancer screening services in Canada." Thesis, University of British Columbia, 2012. http://hdl.handle.net/2429/42855.

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A qualitative feminist study, informed by social constructionist epistemology, antiracist theories and intersectionality perspectives, was conducted in order to understand South Asian immigrant women’s access to and experiences with breast and cervical cancer screening services in Canada. Particular attention was paid to the wider context of their lives and their experiences of migration, resettlement, integration and general access to the Canadian healthcare system. The study also explored how the broader systems, structures and policies in Canadian society shape South Asian immigrant women’s
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32

Prinsloo, Erna Louisa. "From victims to warriors: collective identity construction at cancer movement assemblies in South Africa." Doctoral thesis, University of Cape Town, 2015. http://hdl.handle.net/11427/16684.

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Includes bibliographical references<br>Interest in this topic was awakened by the rapid growth of Relay For Life in South Africa and its striking ability to bond people during mass cancer gatherings. Questions were raised about the generation of collective identities during these assemblies, the nature of the activated identities, and how these relate to the broader debates about cancer and identity. This inquiry investigates the unexplored intersection of cancer and identity in the context of a burgeoning solidarity movement that has found a strong following countrywide. A contemporary herme
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Abram, Muhammed Hanif. "The incidence of oral and oropharyngeal cancer in South Africa for the five year period 1997-2001." Diss., University of Pretoria, 2013. http://hdl.handle.net/2263/24655.

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The National Cancer Registry (NCR) of South Africa publishes pathology-based cancer incidence in the country and is the main cancer data source. The data published by the NCR have been used extensively in the development of the draft national guidelines for cancer prevention and control as well as for cancer research. The list of contributing pathology laboratories is fairly inclusive. As far as Oral Cancer is concerned, the Department of Oral Pathology, University of Limpopo, has however not submitted data to the NCR. It is therefore reasonable to assume that because of this, a large proporti
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Rambalee, Veneesha. "Effects of 2-methoxyestradiol, an endogenous estrogen metabolite, on SNO and WHCO3 oesophageal cancer cell growth." Diss., Access to E-Thesis, 2003. http://upetd.up.ac.za/thesis/available/etd-09272005-143729/.

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35

Sibeko, Lindiwe Nobesuthu. "Acceptability and feasibility of heat-treated expressed breastmilk following exclusive breastfeeding by HIV-1 infected South African women." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=103386.

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Qualitative and quantitative research methods were employed to evaluate the acceptability and feasibility of HIV-1 infected, urban South African mothers being able to feed their infants heat-treated expressed breast milk (HTEBM). Nutritional status assessment of HIV-infected breastfeeding mothers (n=84) indicated that maternal status was not compromised; mean body mass index 26.8 (4.0) kg/m2, triceps skinfold 14.8 (5.50) mm and hemoglobin 11.6 (1.49) g/dL. However, severely immunocompromised mothers (CD4 + &lt; 200 cells/mm3) were more likely to be anemic. Breastmilk viral loads were also high
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Prodehl, Leanne. "Triple negative breast cancer in South Africa." Thesis, 2016. http://hdl.handle.net/10539/22459.

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MBChB FCS (SA) Cert GIT Department of Surgery University of the Witwatersrand<br>There were 275 patients with triple negative breast cancer identified out of 1898 patients (14.4%). The prevalence at Milpark Breast Care Unit was 13.9% and 16.1% at Helen Joseph Hospital. 135 patients were further analysed. Stage at presentation was IIa and IIb in approximately half (47.23%) of the patients. Patients presented with large tumours - 57.78% greater than two centimeters, and lymph node positive disease (55.55%). The majority (72.73%) of patients had high-grade, poorly differentiated tumours.
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Bhana-Nathoo, Deepa. "Imaging features of triple negative breast cancer in a tertiary hospital in South Africa." Thesis, 2019. https://hdl.handle.net/10539/28176.

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A research report submitted to the Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, in partial fulfilment of the requirements for the degree of Master of Medicine in Diagnostic Radiology Johannesburg, 2019<br>INTRODUCTION Breast cancer is one of the leading causes of cancer deaths worldwide. Triple negative breast Cancer (TNBC) is an aggressive subtype, commonly described as presenting at a younger age, in women of African descent and in low socioeconomic groups. Commonly it demonstrates benign imaging features making diagnosis a challenge. Early detection and
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Van, der Wiel Renee. "Unravelling stereotype, unanticipated sociality : breast cancer treatment at a public healthcare facility in post-apartheid Johannesburg." Thesis, 2013. http://hdl.handle.net/10539/13184.

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This dissertation presents an ethnographic account of a socially diverse, public breast cancer clinic in Johannesburg. The findings of this qualitative research radically challenge the unproblematised and overdetermined use of the categories of race and gender in existing literature concerning this disease. The growing breast cancer epidemic in South Africa affects all demographic categories of women including young women. Yet, previous research frames this as a racialised and gendered crisis. Black women have been depicted as ignorant “problem patients” who resist biomedical treatment, and al
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Langa, Bridget Cebisile. "Genomic instability in South African breast cancer patients." 2013. http://hdl.handle.net/11394/3600.

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Magister Scientiae (Medical Bioscience) - MSc(MBS)<br>Breast cancer (BC) is one of the most common malignancies in women. Death results from treatment failure and metastatic disease. Thousands of lives might be saved if it was possible to detect and eliminate occult metastatic cells before they become clinically evident. Therefore, there is a critical need to identify new markers to improve treatment options for these patients. Genomic instability is the earliest indication of breast cancer and the use of genomic methodologies is a progress towards early detection and treatment, through the id
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40

De, Vos Cheryl Lisa. "Breast cancer in the Ashkenazi Jewish population of South Africa: some psychosocial issues." Thesis, 2014.

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Specific mutations in the breast cancer susceptibility genes 1 and 2 (BRCA1 and BRCA2) have been found to be the cause of breast cancer (BRCA) in about 20% of cases in the Jewish population. Affected women often experience a variety of emotional and social issues, which need to be addressed. The aim o f this study was to investigate some o f the psychosocial issues associated with BRCA, the knowledge o f and feelings about it, its treatment and screening strategies, and attitudes to genetic testing in Ashkenazi Jewish women. The subjects were women aged > 18 years with BRCA (30 subjects, Gro
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Choene, Mpho Susan. "Evaluating the effect of South African Herbal extracts on breast cancer cells." Thesis, 2013. http://hdl.handle.net/10539/12362.

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In this research we aimed to investigate the anti-proliferative properties of three South African plants: Kedrostis foetidissima, Euphorbia mauritanica and Elytropappus rhinocerotis against breast cancer cells. This was done on the basis of their documented ethno-medicinal use against cancer and other ailments. The plant extracts were screened for cytotoxicity and pro-apoptotic activity against two breast cancer cell lines MCF-7 and YMB-1. With an IC50 ~ 100 μg/ml, K. foetidissima was the only extract that exhibited significant cytotoxicity on both cell lines, whilst E. mauritanica was cytotox
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Moodley, Louise Claire. "Existential reflections of South African women with breast cancer." Thesis, 2012. http://hdl.handle.net/10539/11327.

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The period following a breast cancer diagnosis has been described as a time of reflection and inward search for existential meaning. The purpose of this study was to explore how South African women dealt with suffering, the possibility of death and found meaning in their diagnosis and ensuing treatment and its termination. This sample comprised of eight South Africa women between the ages of 30 to 57 years, diagnosed with breast cancer, and who had terminated active oncology treatment. The design of the study was qualitative. Semi-structured interviews were utilised to examine the existe
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Abrahams, Odette Natasha. "Occupations and breast cancer in women treated at a tertiary hospital in Johannesburg." Thesis, 2015. http://hdl.handle.net/10539/17428.

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Submitted a requirements for the degree of Master of Medicine in the branch of Community Health (Occupational Medicine). It has not been used, either wholly or partially, for any other degree or examination at this or any other university.<br>Introduction This is the first study in South Africa to look for an association between breast cancer and occupations in black women. Breast cancer is one of the commonest forms of malignancy experienced by women in South Africa and its incidence is increasing (1). Approximately six million women work in South Africa, some of these women are likely
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Singh, R. "The relationship between stressful life events, locus of control and the onset of breast cancer." Thesis, 2012. http://hdl.handle.net/10210/6745.

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Mertz, Magaretha Susara. "Quality of life in patients with metastatic breast cancer : A South African perspective." Thesis, 2000. http://hdl.handle.net/2263/28399.

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Mdondolo, Nosipho. "Cultural factors associated with management of a breast lump amongst Xhosa women." Diss., 2002. http://hdl.handle.net/10500/609.

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A qualitative research design and an ethno-nursing research method were used to identify cultural factors influencing Xhosa women's health seeking behaviours associated with breast lumps. Focus group interviews were conducted to obtain data. The research results revealed that these Xhosa women with breast lumps did not disclose some cultural factors which influenced their health seeking behaviours associated breast lumps. Registered nurses, sharing the same culture and language as the Xhosa women, revealed that Xhosa women with breast lumps sought treatment from traditional healers, prior to
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Levin, Debra. "Team-patient communication of information and support at the Breast Cancer Clinic of the Johannesburg Hospital." 1997. http://hdl.handle.net/10500/17206.

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This study addresses the effectiveness of communication between the team (doctors, sisters and social workers) and patients at the Breast Cancer Clinic of the Johannesburg Hospital. Tue needs of patients were highlighted, as well as the role of care-giver, both as a group and in their separate disciplines, in attempting to meet these needs. Tue empirical survey was carried out through the use of questionnaires as well as interview schedules. Patients, doctors, nurses and social workers were used as respondents. Results indicated that the majority of patients' needs for information and support
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Herd, Olivia Jayne. "Analysis of radiosensitivity in South African cervical and breast cancer patients." Thesis, 2015. http://hdl.handle.net/10539/18487.

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Introduction: Ionising radiation can cause DNA double strand breaks (DSB), that result in chromosomal aberrations if un- or mis-repaired. Individuals with compromised DNA damage repair mechanisms display increased chromosomal radiosensitivity. The G0-micronucleus assay (MN assay) and the γ-H2AX assay are two assays used in radiobiology to study DNA DSB and repair. Breast cancer is the leading cancer amongst South African women, with a lifetime risk of 1 in 34. Since most cancer patients in South Africa present with late-stage disease, chemotherapy and radiotherapy are commonly-used treatments
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Kaloianova, Maria Simeonova. "Imaging features of male breast cancer in a South African population." Thesis, 2017. https://hdl.handle.net/10539/24861.

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A research report submitted to the Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, in partial fulfilment of the requirements for the degree of Master of Medicine in Diagnostic Radiology Johannesburg, 2017.<br>INTRODUCTION: Male breast cancer is a very rare entity, representing less than 1% of all cancers affecting men (1, 2). Only 0.7% of all breast carcinomas are attributed to male breast cancer (3). As a result, there is little published data worldwide and especially from South Africa about the imaging features of breast malignancy in men. This study looked at the
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Moukangoe, Phaswane Isaac Justice. "The association of night-shift work with the development of breast cancer in women." Diss., 2013. http://hdl.handle.net/10500/14143.

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Breast cancer poses a serious public health concern. This case-control study describes the relationship of night-shift working on the development of breast cancer in 57 women diagnosed with breast cancer compared to 49 women with other types of cancer in the Vaal Triangle area (selected through non-probability purposive sampling from CANSA). The study revealed that women who work night-shift developed breast cancer 1.24 times more often than women who do not work nightshift (OR=1.24 [95% CI 0.52 to 2.89]). The odds ratio was further increased in women who worked rotating-shift (OR=1.44
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