Relevant bibliographies by topics / Breast cancer treatment][Cancer / Dissertations / Theses
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Dissertations / Theses on the topic 'Breast cancer treatment][Cancer'

Author: Grafiati
Published: 4 June 2021
Last updated: 11 February 2022

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1

Li, Pei-Xiang. "Molecular approaches to breast cancer treatment." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0023/NQ50092.pdf.

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2

Abraham, J. E. "The pharmacogenetics of breast cancer treatment." Thesis, University of Cambridge, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.595327.

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The core project in this thesis is the translational study PGSNPS, which aimed to investigate the pharmacogenetics of breast cancer chemotherapy in the adjuvant setting. Blood or saliva samples were collected from over 2300 patients, who were recruited during a 4 year period. The trial design was adapted to a GWAS approach. The combination of high quality genotype data and detailed clinical information allows this collection to be a useful resource not only for pharmacogenetic analysis but for investigation of prognosis and susceptibility in future analyses. I also examined the role of candida
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3

Whitman, Birgit. "Breast cancer : patient narratives and treatment methods." Thesis, University of Glasgow, 2004. http://theses.gla.ac.uk/2969/.

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This thesis concentrates on the treatment of women with breast cancer in the 19th and 20th century. It analyses written published patient narratives linking them with clinical developments. Medical history holds a rich source of information providing the view of the clinician. This includes case reports and case series from one surgeon or one hospital for the earlier period of the study and has progressed to the double blind randomised controlled trial that dominates comparative research today. There is an imbalance in the material available for the analysis of patients’ perceptions of their t
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4

Bossaer, John B., and Christian M. Thomas. "Adjuvant Treatment of Newly Diagnosed Breast Cancer." Digital Commons @ East Tennessee State University, 2011. https://dc.etsu.edu/etsu-works/2313.

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5

Keim, Rebecca. "Treatment-Induced Breast Cancer Dormancy and Relapse." VCU Scholars Compass, 2014. http://scholarscompass.vcu.edu/etd/3500.

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When breast tumor cells encounter stress due to cancer therapies, they may enter a dormant state, escaping from treatment-induced apoptosis. Dormant cells may eventually regain proliferative capabilities and cause recurrent metastatic disease, which is the leading cause of mortality in breast cancer patients. We sought to determine if a high dose of radiation therapy (RT) or combined chemo-immunotherapy, with and without the blockade of autophagy by chloroquine (CQ), could overcome treatment-induced tumor dormancy or relapse. We found that autophagy contributes in part to treatment-induced tum
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6

Thanoon, David. "Computational framework for local breast cancer treatment." Thesis, Bordeaux 1, 2011. http://www.theses.fr/2011BOR14387/document.

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Le cancer du sein est le cancer le plus fréquent chez les femmes. Il y a une multitude de solutions proposées concernant une éventuelle intervention médicale pour le cancer du sein ‐ une en particulier est la chirurgie mammaire conservatrice (tumoréctomie). Le but de la tumoréctomie est de parvenir à un contrôle local du cancer, ainsi que de préserver une forme du sein qui satisfait les besoins esthétiques de la femme. Bien que ces objectifs sont généralement atteint, il reste encore parfois des résultats inattendus,tels qu'une tumeur récurrence locale, ou des résultats cosmétiques insuffisant
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7

Donaghy, Kathleen B. "Biopsychosocial factors in breast cancer." Virtual Press, 1997. http://liblink.bsu.edu/uhtbin/catkey/1115723.

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In the treatment of early stage breast cancer, both mastectomy and lumpectomy followed by radiation therapy have been recognized as having similar survival rates. Increasingly, women are being given the opportunity to choose which of these surgical treatment options they wish to pursue. Decisions tend to be made rather quickly, and some women may later regret their treatment choice. In this study, an instrument (Breast Cancer Treatment Inventory (BCTI)) was developed that identified five primary sources of influence that affect women's breast cancer treatment decisions: cosmetic outcome, prepa
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8

Fleischer, Anne. "Exploratory study of breast cancer survivors' lived experience : activity engagement during and after breast cancer treatment." Diss., NSUWorks, 2015. https://nsuworks.nova.edu/hpd_ot_student_dissertations/34.

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The aim of this study is to describe breast cancer survivors' experiences and the associated meanings participating in their important activities during and after breast cancer treatment and the relationship among the survivor, environment, occupation, and performance, using a concurrent mixed method design. Ten survivors between the ages of 45 and 64 with Stage I, II, or III breast cancer who had been treated consecutively with surgery, chemotherapy, and radiation therapy were recruited for the study. Each survivor completed the Activity Card Sort-modified scoring system (ACSm) during the fir
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9

Molenaar, Jacobus. "Treatment decision support for early breast cancer patients." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2004. http://dare.uva.nl/document/77496.

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10

Smoot, Betty. "Upper extremity function following treatment for breast cancer." Diss., Search in ProQuest Dissertations & Theses. UC Only, 2009. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3359582.

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11

Volpari, Tatiana. "Residual breast cancer metabolic phenotype after docetaxel treatment." Thesis, University of Birmingham, 2016. http://etheses.bham.ac.uk//id/eprint/6710/.

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Despite improvements in early diagnosis and prevention, late stage breast cancer is often incurable due to metastasis, tumour relapse, resistance and incomplete response to treatments. Metabolic reprogramming has been recognised as a critical element for cancer cells to grow under hostile conditions and this is likely to contribute towards resistance against chemotherapeutics. This thesis therefore aimed at deciphering the metabolic phenotype of residual breast cancer which survived docetaxel treatment, in vitro and in vivo, quantifying polar metabolite levels and conducting pathway tracing an
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12

Latif, Ay§e. "Genetics of breast cancer susceptibility and treatment response." Thesis, University of Manchester, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.525641.

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13

Ertefai, Benyamin. "Resistance mechanisms during endocrine treatment in breast cancer." Thesis, Cardiff University, 2016. http://orca.cf.ac.uk/95393/.

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Prolonged endocrine therapy is the mainstay of treatment for ER+ breast cancer patients. However, resistance develops in many patients which leads to more aggressive disease. Understanding the mechanisms of acquired resistance that emerge as a consequence of prolonged endocrine treatment remains critical. This study aimed to use gene expression profiling to discover induced mechanisms shared by a panel of MCF7-derived acquired resistant cells that underpin endocrine resistant growth. The in vitro panel represents resistance to oestrogen deprivation, tamoxifen or fulvestrant and includes long-t
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14

Janodien, Fatima. "Proteome signature of breast cancer cells treated with fucoidan." University of the Western Cape, 2016. http://hdl.handle.net/11394/5315.

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>Magister Scientiae - MSc<br>Breast cancer is responsible for a large portion of cancer-related deaths. Worldwide, incidence is increasing. Routinely-used treatments for breast cancer are invasive and are associated with a range of side-effects which may affect quality of life. Fucoidan, a marine bioactive compound, found primarily in brown seaweed, has various medicinal qualities. Among its bioactivities studied, it has potent anticancer activity. Despite numerous studies, the mechanism of action of fucoidan on cancer cells remains unclear. This project aims to shed light on the mechanism of
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15

Desmedt, Christine. "Multi-marker detection approach for improving breast cancer treatment tailoring." Doctoral thesis, Universite Libre de Bruxelles, 2008. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210415.

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the majority of patients with early breast cancer receive some form of systemic adjuvant therapy (chemo-, endocrine, and/or targeted therapy). Despite the increase in adjuvant therapy prescription, little progress has been made with respect to assisting oncologists to determine which breast cancer patients, particularly those deemed at “lower risk” of relapse, require chemotherapy or other systemic therapy and which women can safely be treated with loco-regional treatment alone. For these reasons, the identification of prognostic and predictive markers that will assist the clinician in selecti
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16

Chiwakata, Maynard Tendai. "The synthesis and breast cancer inhibitory activity of cinnamic acid analogues based on the halogenated monoterpene pharmacophore." Thesis, Rhodes University, 2012. http://hdl.handle.net/10962/d1016129.

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Breast cancer is one of the leading causes of death, with mortality rate estimates of 465 000 deaths per annum. It is estimated that 1.3 million women are diagnosed with the disease each year especially in the developing countries. Current chemotherapy relies on the use of high doses of non-specific toxic agents that possess adverse side effects and compromise patient’s compliance and adherence to treatment. Paclitaxel, one of the common drugs used in breast cancer chemotherapy results in sensory and motor neuropathy, whilst hormonal therapy e.g. Herceptin causes severe cardiovascular, gastroi
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17

Brand, Juanita M. "The lived experiences of six women during adjuvant chemotherapy for Stage I or II breast cancer." Virtual Press, 2005. http://liblink.bsu.edu/uhtbin/catkey/1317926.

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18

Latella, Jennifer. "Lymphedema after treatment for breast cancer : a pilot study." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=99343.

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Despite more conservative surgical treatment for breast cancer, lymphedema and arm dysfunction remain sources of significant morbidity. The study for this thesis was conducted to explore methods for defining and identifying lymphedema and arm dysfunction after treatment for breast cancer.<br>In order to establish cut-points in the differences in the sizes of arms to define the presence of lymphedema among women previously treated for breast cancer, the distributions of the differences in the sizes of arms, using measures of circumference and volume, among 40 women with no history of breast can
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19

MacPhee, Meaghan. "Stabilized combi-molecules for the treatment of breast cancer." Thesis, McGill University, 2009. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=40846.

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We recently developed a novel strategy termed “combi-targeting” that seeks to design “combi-molecules” which are able to not only block EGFR but to also damage DNA. Previous studies that sought to stabilize triazene based combi-molecules were based on masking the 1,2,3-triazene chain with a 2-acetoxymethylene group, leading to the synthesis of RB24 and RB107. The half-lives of these two molecules proved to be only about 5 minutes longer than their parent triazenes. The novel series of molecules presented herein were designed containing hydrolysable groups to modulate the kinetics of their degr
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20

Buijs, Ciska. "Long-term side effects of adjuvant breast cancer treatment." [S.l. : Groningen : s.n. ; University Library of Groningen] [Host], 2008. http://irs.ub.rug.nl/ppn/306087480.

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21

Crane, Elizabeth. "Health Care Systems Factors Affecting Breast Cancer Treatment Choices." Thesis, The University of Arizona, 2010. http://hdl.handle.net/10150/156910.

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The purpose of this research was to explore and describe health care systems factors that influence treatment decisions for women with breast cancer in the United States (U.S.) and Norway. The specific aims of the study were to: (a) explore and describe how health care systems processes create barriers and facilitators of breast cancer treatment decisions for patients diagnosed with breast cancer in the US and Norway; and (b) compare and contrast the US and Norwegian system processes to identify advantages and disadvantages of each system as they relate to breast cancer treatments. A descripti
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22

Vaidya, Jayant Sharad. "A novel approach for local treatment of breast cancer." Thesis, University College London (University of London), 2002. http://discovery.ucl.ac.uk/18745/.

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Early local recurrence of breast cancer most commonly (over 90%) occurs at the site of the primary tumour. This is true whether or not radiotherapy is given and irrespective of the margin status. Whole-organ analysis of mastectomy specimens on the other hand, reveals that 63% of breasts harbour occult cancer foci and 80% of these are situated remote from the index quadrant. Therefore, these occult cancer foci may be clinically irrelevant and it may not be necessary to treat the whole breast with radiotherapy. This 6-wks long course of post-operative radiotherapy after breast conserving therapy
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23

O'Brien, Ciara. "Breast cancer initiating cells in tamoxifen treatment and resistance." Thesis, University of Manchester, 2012. https://www.research.manchester.ac.uk/portal/en/theses/breast-cancer-initiating-cells-in-tamoxifen-treatment-and-resistance(074d121d-d39b-413d-ae0c-ae54ae1c0293).html.

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Resistance to endocrine treatments in oestrogen receptor positive (ER+) breast cancer (BC) significantly contribute to patient morbidity and mortality. ER+ BC constitute 60% of all breast cancers although there is considerable clinico-pathological diversity within this group. Breast cancer initiating cells (BCICs) are implicated in tumour relapse and metastasis and are postulated to drive resistance to standard anti-cancer therapies. However little is known about the sensitivity of BCICs to endocrine therapies. We assessed the effect of tamoxifen treatment and acquired tamoxifen resistance on
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24

Giallourou, Natasa. "Watercress as a nutritional adjuvant treatment in breast cancer." Thesis, University of Reading, 2017. http://centaur.reading.ac.uk/76171/.

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Breast cancer is a leading cause of cancer related mortality globally, and epidemiological studies suggest a link between healthy nutrition and cancer prevention. Members of the Brassicaceae family, including watercress, have been extensively studied for their anti-cancer and anti-genotoxic potential. Watercress has a complex phytonutrient profile characterised by high levels of carotenoids, flavonols and glucosinolates. Extracts of watercress exhibit strong antioxidant capacity in vitro. Watercress and its components have been associated with the inhibition of the three stages of carcinogenes
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25

Gross, Brett Patrick. "Therapeutic vaccination for the treatment of metastatic breast cancer." Diss., University of Iowa, 2018. https://ir.uiowa.edu/etd/6119.

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Metastatic breast cancer is a leading cause of cancer-related mortality worldwide. While existing interventions are effective at treating localized tumors, disseminated malignancies remain incurable. Vaccine-induced anti-tumor immunity is a promising approach for treating disseminated tumors, as immune responses are systemic, have antigen-restricted cytotoxicity, and generate protective immune “memory” populations. Our group has developed a novel heterologous prime/boost vaccine protocol that treats
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26

Tse, Ka-ho, and 謝家豪. "A comparison of contralateral breast dose from primary breast radiotherapy using different treatment techniques." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/206498.

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Breast cancer is the most common cancer among women worldwide. Millions of new breast cancer cases are diagnosed every year, accounting for one-tenth of all new cancer cases. Because of the proof of equivalent efficacy between breast-conserving therapy (BCT) plus radiotherapy and mastectomy, increasing number of patients received breast irradiation during the past three decades, and radiotherapy plays a more and more important role in managing breast cancer. With the advancement of technology, the radiotherapy treatment techniques changed from conventional wedged technique to intensity modulat
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27

Hammond, Lynn C. "A qualitative study of treatment issues of eight women with breast cancer." Morgantown, W. Va. : [West Virginia University Libraries], 2000. http://etd.wvu.edu/templates/showETD.cfm?recnum=1645.

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Thesis (Ph. D.)--West Virginia University, 2000.<br>Title from document title page. Document formatted into pages; contains vii, 271 p. : ill. Vita. Includes abstract. Includes bibliographical references (p. 225-231).
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28

Bennett, Barbara Kaye School of Medicine UNSW. "Characterising the nature of postcancer fatigue in women treated for early-stage breast cancer." Awarded by:University of New South Wales. School of Medicine, 2006. http://handle.unsw.edu.au/1959.4/31202.

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The problem investigated Four studies investigated the phenomenon of cancer-related fatigue (CRF) in women who had received adjuvant treatment for early-stage breast cancer, with a view to reducing the diagnostic uncertainty surrounding the syndrome and thus facilitating progress in both clinical management and aetiological research. Procedures and results A cross-sectional study of 109 women compared a ???cancer-specific??? self-report questionnaire (FACT-F) (canvassing fatigue symptoms) and a more generic questionnaire (SPHERE) (identifying depression and fatigue). Thirty-seven percent of wo
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29

Cannon, S. "Female breast cancer : The individual experience and social organisation of its diagnosis and treatment." Thesis, Staffordshire University, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.384660.

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30

Jones, Simon Keith. "Mathematical modelling for early detection and treatment of cancer." Thesis, University of Southampton, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.241869.

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31

Swartz, Esti. "Emotional intelligence and locus of control of adult breast cancer patients receiving treatment." Thesis, Nelson Mandela Metropolitan University, 2010. http://hdl.handle.net/10948/d1015686.

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Breast cancer is the most prevalent cancer of women in South Africa, with one in twenty-seven women diagnosed with breast cancer in their lifetime. By building on human strengths, ways can be found to cope effectively with adversity. This will contribute to psychological well-being and result in living constructive and meaningful lives. Emotional intelligence and locus of control are two constructs which, according to previous research, may be associated with psychological wellbeing. Limited research has been conducted on these constructs in populations facing adversity. Adaptation to breast c
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32

Costanzo, Erin Susan. "Post-treatment adjustment and behavior change among women with breast cancer." Diss., University of Iowa, 2006. http://ir.uiowa.edu/etd/56.

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33

Lawson, Jessica Clair. "Analysis of the anti-cancer activity of novel indigenous algal compounds in breast cancer: towards the development of a model for screening anti-cancer stem cell activity." Thesis, Rhodes University, 2010. http://hdl.handle.net/10962/d1003984.

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Breast cancer, the most common malignancy diagnosed in women, is one of the leading causes of death in women worldwide. In South Africa only 32% of women diagnosed with advanced breast cancer survive more than five years. The search for new chemotherapeutic agents capable of effectively treating breast cancer is therefore essential. Recent evidence supporting the cancer stem cell theory of cancer development for breast cancer challenges the current theories of cancer development and hence treatment. Cancer stem cells are a small subpopulation of tumour cells that possess properties of both can
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34

Frisk, Jessica. "Acupuncture treatment for hot flushes in women with breast cancer and men with prostate cancer." Doctoral thesis, Linköpings universitet, Obstetrik och gynekologi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-68806.

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Background: The group of women and men with a history of cancer and distressing hot flushes and sweating is growing. The flushes negatively affect Health Related Quality of Life (HRQoL), perhaps partially by disturbing sleep. Treatments that are effective, tolerable and safe need to be developed. There are a number of treatment alternatives that are often not very effective or associated with more or less serious side-effects. Based on theories on the mechanisms behind hot flushes and acupuncture, treatment with acupuncture has been tried in menopausal women with hot flushes and in a few studi
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35

Blackwelder, Reid B. "Integrative Approaches to Treating Patients with Breast Cancer." Digital Commons @ East Tennessee State University, 2007. https://dc.etsu.edu/etsu-works/6985.

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36

Saarela, A. (Arto). "Diagnosis and surgical treatment of suspicious nonpalpable breast lesions and early breast cancer." Doctoral thesis, University of Oulu, 1999. http://urn.fi/urn:isbn:9514253604.

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Abstract The purposes of the present research were to evaluate (1) the value of ultrasonographically guided fine-needle aspiration biopsy (US-FNAB) in nonpalpable suspicious breast lesions, (2) the preoperative use of methylene blue staining in nonpalpable galactographically suspicious breast lesions, (3) the determinants of positive histologic margins and residual cancer in wire-guided biopsy (WGB) of nonpalpable breast cancer and in lumpectomy for early breast cancer and the determinants of positive radiologic margins and the correlation between radiologic and histologic margins and
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37

Deng, Hou Liang. "Characterizing a novel component of polycomb repressive complex 1 (PRC1) and the functions of CBX6 in breast cancer." Thesis, University of Macau, 2018. http://umaclib3.umac.mo/record=b3953848.

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38

Das, Neves Henrique Coutinho Póvoas Esteves. "MCM10, CDT1 and CDC6 as prognostic biomakers and drivers of breast cancer." Thesis, University of Macau, 2018. http://umaclib3.umac.mo/record=b3953629.

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39

Antoine, Caroline. "Menopause, breast cancer and menopausal treatments." Doctoral thesis, Universite Libre de Bruxelles, 2018. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/271843.

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RESUME Introduction: Le cancer du sein (CS) est le cancer le plus fréquent chez la femme. Le risque de CS est influencé par de nombreux facteurs. Le traitement hormonal de la ménopause (THM) est l’un d’entre eux. Le risque de CS associé au THM varie probablement en fonction de la population traitée, du type de traitement utilisé, de la durée du traitement et du moment où il est instauré par rapport au début de la ménopause. Il existe des alternatives au THM pour soulager les symptômes de la ménopause. Quelques traitements ont montré une certaine efficacité mais présentent des effets secondaire
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40

Ouimet, Lea Ann Maria. "A Quantitative Analysis of Cognitive Impairments Following Breast Cancer Treatment." Thesis, Université d'Ottawa / University of Ottawa, 2011. http://hdl.handle.net/10393/19769.

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One in nine North American women will be diagnosed with breast cancer in their lifetime and most will receive chemotherapy as part of their treatment. Although advances in treatment have increased survivorship, some research suggests chemotherapy results in cognitive deficits in a subset of recipients, a condition known as chemo-fog, thereby compromising quality of life. However, inconsistencies in methodology and neuropsychological assessment have complicated comparison of findings. The first objective of this thesis was to review the methodological issues with an emphasis on the quantitative
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Abedin, Farhana. "Magnetic and albumin targeted drug delivery for breast cancer treatment." Thesis, Wichita State University, 2011. http://hdl.handle.net/10057/5054.

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This research work involves multifunctional magnetically targeted drug delivery microspheres for treatment against breast cancer. A combination therapy approach was followed by encapsulating two chemotherapeutics, 5-Fluorouracil (5-Fu) and cyclophosphamide in poly(D, L-lactide-co-glycolide) (PLGA) microspheres. Magnetite nanoparticles and albumin were also incorporated in the microspheres to achieve targeted treatment. The microspheres were fabricated using oil-in-oil emulsion/solvent evaporation technique. Albumin is attracted to cancer cells and thus it is likely to draw the microspheres tow
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42

Lambe, Camille Eckerd Germino Barbara B. "Complementary and alternative therapy use during treatment of breast cancer." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2006. http://dc.lib.unc.edu/u?/etd,671.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2006.<br>Title from electronic title page (viewed Oct. 10, 2007). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the School of Nursing." Discipline: Nursing; Department/School: Nursing.
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Sulaiman, Andrew. "New Approaches for the Treatment of Triple Negative Breast Cancer." Thesis, Université d'Ottawa / University of Ottawa, 2019. http://hdl.handle.net/10393/39100.

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Triple‐negative breast cancer (TNBC) is the most refractory subtype of breast cancer to current treatments and accounts disproportionately for the majority of breast cancer‐related deaths. Research has not yet identified specific therapies for TNBC and chemotherapy remains the conventional therapy in the clinic. While conventional chemotherapy regimens have demonstrated success at reducing bulk tumor burden, they have been shown to enrich cancer stem cells (CSCs). CSCs promote chemoresistance, metastasis, heterogeneous tumor regeneration and disease relapse. Owing to tumor plasticity and the c
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44

Silva, Andreia M. "Investigating c-FLIP suppression and TRAIL treatment in breast cancer." Thesis, Cardiff University, 2017. http://orca.cf.ac.uk/110419/.

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Breast cancer mortality is invariably due to metastasis, the dissemination of cancer cells from the primary tumour to distant organs. This process is proposed to arise from the breast cancer stem cells (bCSCs), the minority of cells within a tumour that are capable of propagating new tumour growth. bCSCs are also associated with potentiating endocrine therapy resistance and therefore relapse after tamoxifen or anastrozole treatments. Tumour necrosis factor-related apoptosis inducing ligand (TRAIL) is an anti-cancer agent that induces apoptosis in bCSCs and has almost no toxicity to normal cell
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45

Chilewski, Shannon D. "Development of CAPER Peptides for the Treatment of Breast Cancer." Thesis, University of the Sciences in Philadelphia, 2020. http://pqdtopen.proquest.com/#viewpdf?dispub=27547515.

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Breast cancer is a leading cancer among women and is a major cause of death worldwide. While not just one disease, breast cancer encompasses many biologically different subtypes with distinct pathologies and clinical ramifications. In the case of estrogen receptor (ER) positive breast cancer, estrogens stimulate mammary epithelial cell proliferation and contribute to the development and progression of the disease. To treat ER-positive breast cancer patients, endocrine targeted therapies such as tamoxifen are commonly used. However, 40–50% of these patients do not respond or develop resistance
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46

Azadbakht, Narges. "Stromal and epithelial changes in breast cancer following endocrine treatment." Thesis, University of Manchester, 2014. https://www.research.manchester.ac.uk/portal/en/theses/stromal-and-epithelial-changes-in-breast-cancer-following-endocrine-treatment(c6542eba-83e2-48de-a566-8f5eccd9a7b1).html.

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Anti-oestrogens and aromatase inhibitors are currently used as endocrine therapies in breast cancer. Despite the significant role that these treatments play in reducing breast cancer mortality, some patients may display intrinsic and acquired therapeutic resistance. Different mechanisms are thought to contribute to endocrine resistance in patients treated with anti-oestrogens such as tamoxifen and aromatase inhibitors such as letrozole. The importance of epithelial-stromal interactions in progression of breast tumour and the potential contribution of these interactions in resistance to tamoxif
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47

Modi, Stephanie. "Lymphatic function in the arm following treatment for breast cancer." Thesis, St George's, University of London, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.486357.

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Aims. The primary aim was to quantify changes in ann lymphatic function after axillary treatment for breast cancer. The hypotheses tested were that [1] impairment ofmuscle lymph drainage after axillary surgery precedes the onset of overt subcutaneous breast cancer related lymphoedema (BCRL); [2] regionality ofswelling in BCRL is due to . local regional impairment oflymph drainage; [3] the force oflymphatic collector pumping is weakened by the chronically raised afterload in BCRL anns. Methods. The removal rate constant, k, was used to measure local lymph drainage of 99mTc-HIG injected jnto the
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48

Conway, Brianna. "Searching for Synergy: FAK Inhibition in Metastatic Breast Cancer Treatment." Thesis, Université d'Ottawa / University of Ottawa, 2018. http://hdl.handle.net/10393/37304.

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Breast cancer is the most common cancer among Canadian women and 14-20% will develop lethal metastases within 5 years. A potential novel therapeutic target is Focal Adhesion Kinase (FAK), a cytoplasmic tyrosine kinase. FAK’s expression is inversely correlated with survival and is known to regulate cell migration, proliferation and invasion. While tyrosine kinase inhibitors are historically ineffective as single agents, they are commonly used as part of combination therapies. Therefore, given its central role in tumor cell biology and cell signaling, we hypothesized that inhibiting FAK in comb
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49

Johansson, David. "Bacterial toxins for cancer treatment." Doctoral thesis, Umeå universitet, Medicinsk biovetenskap, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1637.

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Even though anti‐cancer chemotherapy has been continuously improved during the last decades. problems with adverse effects and drug resistance still constitutes a considerable obstacle and sets a demand for new effective treatment options. Tissue homeostasis in multi‐cellular organisms is maintained through intrinsic cell death, apoptosis, which removes unwanted or damaged cells. Disrupted apoptosis is an important factor in tumorgenesis and drug resistance, therefore induction or restoration of apoptotic pathways is also important for the treatment of cancer. Several naturally occurring bacte
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50

Reed, Alyssa, and University of Lethbridge Faculty of Arts and Science. "Variation in waiting times from diagnosis to treatment for breast cancer patients in Alberta from 1997-2000." Thesis, Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2003, 2003. http://hdl.handle.net/10133/196.

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There is considerable evidence that delays in diagnosing and treating breast cancer reduce long-term survival. The purpose of this study was to assess the waiting time between diagnosis and treatment for Alberta women with breast cancer and to examine the influence of age, cancer stage, Regional Health Authority (RHA), community size, and year of diagnosis on this time interval. The data were obtained from the Alberta Cancer Board. The information included approximately all Alberta women with breast cancer between 1997 and 2000. The overall median waiting time was 17 days. The mean and median
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