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Journal articles on the topic 'Breast Metastasis'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Markovic, Marina, Dalibor Jovanovic, Zeljko Todorovic, et al. "Primary Small Cell Carcinoma Of Lung With Metachronous Breast Metastasis." Serbian Journal of Experimental and Clinical Research 18, no. 3 (2017): 263–67. http://dx.doi.org/10.1515/sjecr-2016-0087.

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Abstract Breast metastases from an extra-mammary malignancy are rare. Among the lung malignancies that metastasise in the breasts, previous literature has described approximately 30 cases of NSCLC and only a few cases of SCLC. Here, we present a 54-year-old woman with metachronous breast metastasis from pulmonary small cell carcinoma. She presented with a soft tissue mass in the right lung hilum. After bronchoscopy with biopsy, SCLC was verified. Th e patient was given 4 cycles of etoposide and cisplatin followed by radiation therapy. Seven months after the diagnosis of primary lung cancer, th

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2

Saad Abdalla Al-Zawi, Abdalla, Andrzej Ratajczak, Philip Idaewor, et al. "Primary lung cancer with metastasis to the ipsilateral breast-a case report." International Journal of Research in Medical Sciences 6, no. 1 (2017): 334. http://dx.doi.org/10.18203/2320-6012.ijrms20175744.

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The metastasis of extra-mammary malignancy to breast is extremely rare; literature reports the incidence between 0.4-1.3%. Primary sites include the contralateral breast, leukaemia, lymphoma, malignant melanoma, sarcoma, lung, prostate, ovary, colon and the stomach. Here we present a rare case in which lung cancer was found to metastasise to the breast. Initially the patient presented with chest symptoms and a left breast lump was detected clinically. The radiological and histological investigations confirmed the diagnosis of primary lung cancer with breast metastases. Prognosis of such cases

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3

Costa, Weruska Alcoforado, José Eleutério Jr., Paulo César Giraldo, and Ana Katherine Gonçalves. "Quality of life in breast cancer survivors." Revista da Associação Médica Brasileira 63, no. 7 (2017): 583–89. http://dx.doi.org/10.1590/1806-9282.63.07.583.

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Summary Objective: To evaluate the influence of functional capacity (FC) and how it affects quality of life (QoL) in breast cancer survivors. Method: A total of 400 breast cancer survivors were studied - 118 without metastasis, 160 with locoregional metastasis and 122 with distant metastasis. The European Organization for Research and Treatment for Cancer Quality of Life Questionnaire--Core 30 (EORTC QLQ-C30), Breast Cancer-Specific (EORTC QLQ-BR23), and the Karnofsky Performance Scale (KPS) were used to evaluate FC and QoL. Results: Women with distant metastases presented lower KPS 75.3 (SD=1

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4

Kayılıoğlu, Selami Ilgaz, Cihangir Akyol, Ebru Esen, et al. "Gastric Metastasis of Ectopic Breast Cancer Mimicking Axillary Metastasis of Primary Gastric Cancer." Case Reports in Gastrointestinal Medicine 2014 (2014): 1–5. http://dx.doi.org/10.1155/2014/232165.

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Ectopic breast tissue has the ability to undergo all the pathological changes of the normal breast, including breast cancer. Gastrointestinal metastasis of breast cancer is rarely observed and it is very difficult to differentiate gastric metastases from primary gastric cancer. We present a case of 52-year-old female, who suffered from abdominal pain. Physical examination showed a palpable mass in the left anterior axilla and computerized tomography revealed gastric wall thickening with linitis plastica. When gastroscopic biopsy showed no signs of malignancy, excisional biopsy was performed in

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5

Zhang, Luyan, Xifa Wu, Yong Feng, Linlin Zheng, and Jinbo Jian. "Selenium donors inhibits osteoclastogenesis through inhibiting IL-6 and plays a pivotal role in bone metastasis from breast cancer." Toxicology Research 9, no. 4 (2020): 544–51. http://dx.doi.org/10.1093/toxres/tfaa053.

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Abstract Bone metastases are a frequent complication of breast cancer, and there has been little progress in the treatment of breast cancer patients with bone metastases. The cytotoxicity of selenium donors, including organic selenium and selenium nanoparticles (SeNPs), to cancer cells has been reported previously, but their relationship with bone metastases progression is not fully clear yet. In this study, multicenter clinical exploration was conducted to obtain dietary selenium intakes of breast cancer patients with or without bone metastasis, to study the relationship between selenium and

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Cebeci, Dua, Sirin Yaşar, and Pembegul Güneş. "Periocular Metastasis From Breast Carcinoma:A Case Report." International Journal of Medical Reviews and Case Reports 4, Reports in Neurology, Neurosur (2020): 1. http://dx.doi.org/10.5455/ijmrcr.periocular-metastasis-from-breast-carcinoma.

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Yazdani, Akram, Sara Dorri, Alireza Atashi, Hoda Shirafkan, and Hedieh Zabolinezhad. "Bone Metastasis Prognostic Factors in Breast Cancer." Breast Cancer: Basic and Clinical Research 13 (January 2019): 117822341983097. http://dx.doi.org/10.1177/1178223419830978.

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Objective: Bone is the most common site of metastasis in breast cancer. Prognostic factors for predicting bone metastases in breast cancer are controversial yet. In this study, we investigated clinical factors associated with secondary bone metastasis of breast cancer. Methods: In total, 1690 patients with breast cancer recorded between 2002 and 2012 in Motamed Cancer Institute, Tehran, Iran entered in the retrospective study. We studied age, menopausal status, histologic type, tumor size, number of cancerous axillary lymph nodes, serum concentrations of alkaline phosphatase (ALP), carcinogeni

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8

Al-Muqbel, Kusai M. "Bone Marrow Metastasis Is an Early Stage of Bone Metastasis in Breast Cancer Detected Clinically by F18-FDG-PET/CT Imaging." BioMed Research International 2017 (2017): 1–7. http://dx.doi.org/10.1155/2017/9852632.

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Objective. To determine the value of 18F-FDG PET/CT in detection of bone marrow (BM) metastasis in breast cancer which is considered an early stage of bone metastasis. Patients and Methods. Retrospectively, breast cancer patients with bone metastasis were included. BM metastasis was considered if the lesion was PET positive/CT occult while bone metastasis was considered if the lesion was PET positive/ CT positive. BM metastases were observed sequentially on F18-FDG PET/CT. Results. We included 35 patients. Eighteen patients (51%) had BM metastases in addition to other bone metastases. BM metas

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9

Müller, Volkmar, Elena Laakmann, Astrid Grottke, Kerstin Riecke, and Isabell Witzel. "Cerebral metastasis in breast cancer." Senologie - Zeitschrift für Mammadiagnostik und -therapie 15, no. 04 (2018): 213–18. http://dx.doi.org/10.1055/a-0753-3504.

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AbstractThe incidence of breast cancer brain metastases has risen steadily in recent years. Brain metastases are often the limiting factor of the disease, as survival is usually only a few months after brain metastasis occurs. Apart from the poor prognosis, cognitive and neurological deficits lead to a massive impairment of quality of life. HER2-positive or triple-negative cancers develop brain metastases more often. Studies on the subject of brain metastases were conducted mainly in cohorts with different primary tumours. To improve the available data on patients with breast cancer, the “Brai

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10

Mandaliya, Hiren, Joshua Sung, Joanna Hill, Ramin Samali, and Mathew George. "Prostate Cancer: Cases of Rare Presentation and Rare Metastasis." Case Reports in Oncology 8, no. 3 (2015): 526–29. http://dx.doi.org/10.1159/000442045.

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Prostate cancer is the second most common cancer in men. Diagnosis of early disease is based on prostate biopsy which is carried out because of symptoms of prostatism or asymptomatic rise in PSA. On the other side, advanced disease can locally invade and metastasise to lymph nodes, bones, lungs, etc. Initial presentation of prostate cancer in form of brain metastasis is extremely seldom. Similarly, prostate cancer, which metastasised to the breast, is very rare too. Here, we discuss two unique cases of prostate cancer, one of them had an initial presentation of brain metastasis from prostate a

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11

Dong, Qian, Mi Zhang, and Da Jiang. "Relationship between tumor size and metastatic site in patients with stage IV breast cancer: A large SEER-based study." Journal of Clinical Oncology 39, no. 15_suppl (2021): e13065-e13065. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.e13065.

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e13065 Background: To analyze the correlation between tumor size and metastatic site in first-diagnosed stage IV breast cancer patients. Methods: Stage IV breast cancer patients diagnosed from 2010 to 2015 were screened by the Surveillance, Epidemiology, and End Results (SEER) database. The characteristics of clinical variables were represented by a frequency table, and the Chi-square test was used for comparison. At the same time, the Chi-square test was used to analyze the relationship between tumor size and organ metastasis. Correlation between tumor size and the prognosis of patients was c

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Begum, Shamim MF, Fatima Begum, Pupree Mutsuddy, Layla S. Banu, and Raihan Hussain. "Superficial Metastases from Breast Cancer and Gallbladder: Detected by 18F FDG PET-CT Scan." Bangladesh Journal of Nuclear Medicine 20, no. 1 (2018): 56. http://dx.doi.org/10.3329/bjnm.v20i1.36862.

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<p>Cutaneous and subcutaneous metastases from internal malignancies are rare. The reported incidence of subcutaneous metastasis is 5.3% and cutaneous metastasis account for 0.7% and 9% of all metastases. Here we reported two cases of cutaneous metastasis, one from gall bladder cancer and other from breast cancer. Among all internal malignancies the incidence of cutaneous metastasis in breast cancer is highest whereas in gall bladder cancer is rare. Detection of cutaneous or subcutaneous metastasis determines the staging, prognosis and management strategy of the disease. 18F FDG PET- CT (

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13

Svensson, Elisabeth, Christian F. Christiansen, Sinna P. Ulrichsen, Mikael R. Rørth, and Henrik T. Sørensen. "Survival after bone metastasis by primary cancer type: a Danish population-based cohort study." BMJ Open 7, no. 9 (2017): e016022. http://dx.doi.org/10.1136/bmjopen-2017-016022.

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ObjectiveIn the 10 most common primary types with bone metastases, we aimed to examine survival, further stratifying on bone metastases only or with additional synchronous metastases.MethodsWe included all patients aged 18 years and older with incident hospital diagnosis of solid cancer between 1994 and 2010, subsequently diagnosed with BM until 2012. We followed patients from date of bone metastasis diagnosis until death, emigration or 31 December 2012, whichever came first. We computed 1-year, 3-year and 5-year survival (%) and the corresponding 95% CIs stratified on primary cancer type. Com

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14

Kitahara, Miyuki, Yasuo Hozumi, Rio Asada, Aya Sawa, Hitoaki Saito, and Tatsuo Iijima. "Intramammary Metastasis in a Patient with a History of Renal Cell Carcinoma: A Case Report." Case Reports in Oncology 11, no. 2 (2018): 318–22. http://dx.doi.org/10.1159/000489391.

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Intramammary metastasis of renal cell carcinoma (RCC) is extremely rare, accounting for only 1.5% of all intramammary metastases. Distinguishing intramammary metastases from benign tumors and breast cancer is clinically problematic. Some patients undergo excessive surgery after a misdiagnosis of breast cancer instead of a mammary tumor. We performed a core needle biopsy (CNB) of a breast mass that developed in a 71-year-old woman after surgeries for bilateral RCC and breast cancer, leading to a diagnosis of intramammary metastasis of RCC. In this case, the CNB and immunohistochemical examinati

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15

Tsung, Swei H. "Metastasis of Colon Cancer to the Breast." Case Reports in Oncology 10, no. 1 (2017): 77–80. http://dx.doi.org/10.1159/000455225.

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Breast metastases from extramammary neoplasms are extremely rare, and even more so is metastasis of colon cancer to the breast. Despite its rarity, metastatic disease to the breast is an important diagnostic issue because its treatment differs greatly from that of primary cancer. Proper diagnosis of this rare event requires an accurate clinical history, proper immunohistochemical workup, and a high level of suspicion.

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Shi, Dongning, Junwen Bai, Yibo Chen, Xia Wang, Yafeng Zhang, and Hong Liu. "Predicting the Incidence and Prognosis of Bone Metastatic Breast Cancer: A SEER-Based Observational Study." BioMed Research International 2020 (November 25, 2020): 1–9. http://dx.doi.org/10.1155/2020/1068202.

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Background. To determinate the association relationship of breast cancer bone metastasis and cancer characteristics and molecular subtype. Furthermore, to evaluate the impact of molecular subtype on prevalence and prognosis of bone metastasis from the breast cancer base on a large population real-word program, the Surveillance, Epidemiology, and End Results (SEER) database. Methods. We collected and analyzed the data obtained from SEER, which showed molecular subtype information for each patient. The prevalence and outcome of bone metastasis in breast cancer were estimated as per the different

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17

Medeiros, Braeden, and Alison L. Allan. "Molecular Mechanisms of Breast Cancer Metastasis to the Lung: Clinical and Experimental Perspectives." International Journal of Molecular Sciences 20, no. 9 (2019): 2272. http://dx.doi.org/10.3390/ijms20092272.

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Breast cancer is the most commonly diagnosed cancer in women worldwide, and >90% of breast cancer-related deaths are associated with metastasis. Breast cancer spreads preferentially to the lung, brain, bone and liver; termed organ tropism. Current treatment methods for metastatic breast cancer have been ineffective, compounded by the lack of early prognostic/predictive methods to determine which organs are most susceptible to developing metastases. A better understanding of the mechanisms that drive breast cancer metastasis is crucial for identifying novel biomarkers and therapeutic targets

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18

Haffty, B. G., M. Reiss, M. Beinfield, D. Fischer, B. Ward, and C. McKhann. "Ipsilateral breast tumor recurrence as a predictor of distant disease: implications for systemic therapy at the time of local relapse." Journal of Clinical Oncology 14, no. 1 (1996): 52–57. http://dx.doi.org/10.1200/jco.1996.14.1.52.

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PURPOSE To evaluate the prognostic significance of ipsilateral breast tumor recurrence (IBTR) with respect to the subsequent development of distant metastasis. MATERIALS AND METHODS Between January 1970 and December 1989, 973 patients with invasive breast cancer were treated with conservative surgery and radiation therapy at Yale-New Haven Hospital. The median follow-up time as of December 1993 was 8.6 years. A number of prognostic factors were tested as possible predictors of distant metastases, including whether a patient experienced IBTR. IBTRs were broken down by time to recurrence to dete

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19

Buka, David, Josef Dvořák, Igor Richter, Nikolov Dimitar Hadzi, and Jiří Cyrany. "Gastric and Colorectal Metastases of Lobular Breast Carcinoma: A Case Report." Acta Medica (Hradec Kralove, Czech Republic) 59, no. 1 (2016): 18–21. http://dx.doi.org/10.14712/18059694.2016.50.

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Background: Occurrence of gastric metastasis as the first symptom of breast carcinoma with a long period of latency before presentation of the primary breast carcinoma is rare. Case Report: A patient with gastric metastasis as the first symptom of lobular breast carcinoma, treated by neoadjuvant preoperative chemoradiotherapy and total gastrectomy, with complete local control. Fourteen months after presentation of the gastric metastasis a primary lobular breast carcinoma was discovered, treated by radiotherapy, chemotherapy and hormonal treatment with complete local response. Twenty-three mont

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Schem, C., A. M. Stark, H. M. Mehdorn, W. Jonat, and N. Maass. "Expression of metastasis suppressor gene maspin in breast cancer brain metastases." Journal of Clinical Oncology 24, no. 18_suppl (2006): 20057. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.20057.

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20057 Background: Recently our demonstrated that the expression of several Metastasis Suppressor Genes (MSG) is reduced in breast cancer brain metastases. Current data suggest that MSG Maspin (serpin B5) is a promising candidate for further treatment options. So, we examined the mRNA and protein expression of Maspin in normal breast tissue, breast cancer primaries, -brain metastases and breast cancer cell lines. Methods: Maspin mRNA expression was examined by real time reverse transcription polymerase chain reaction (RT-PCR) in fresh frozen samples from normal breast tissue, breast cancer prim

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Özer, Özge, Emirhan Nemutlu, Cemil Can Eylem, et al. "Detection of brain metastasis by metabolomics methods in metastatic breast cancer patients." Journal of Clinical Oncology 37, no. 15_suppl (2019): e12572-e12572. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.e12572.

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e12572 Background: The aim of this study was to identify markers for the early diagnosis of brain metastasis by metabolomic methods in breast cancer patients. Methods: A total of 88 breast cancer patients with distant metastases were included the study. The patients were divided into two groups according to their metastasis status as patients with brain metastases and patients with distant metastases without any brain metastases. For metabolomic analyses, liquid chromatography quadrupole time-of-flight mass spectrometry (LC-qTOF-MS) and gas chromatography mass spectrometry (GC-MS) analysis met

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Hague, Andrew. "Metastasis Breast Cancer." American Journal of Biomedical Science & Research 1, no. 6 (2019): 254. http://dx.doi.org/10.34297/ajbsr.2019.01.000559.

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23

Marino, Natascia, Stephan Woditschka, L. Tiffany Reed, et al. "Breast Cancer Metastasis." American Journal of Pathology 183, no. 4 (2013): 1084–95. http://dx.doi.org/10.1016/j.ajpath.2013.06.012.

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Hodgdon, Christine, and Laurie Campbell. "OTHR-09. Accelerating Research for Breast Cancer Brain Metastasis and Leptomeningeal Disease through Patient-led Collaborations." Neuro-Oncology Advances 3, Supplement_3 (2021): iii16. http://dx.doi.org/10.1093/noajnl/vdab071.064.

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Abstract Patient-driven Initiative of the Metastatic Breast Cancer (MBC) Alliance The Breast Cancer Brain Metastasis (BCBM) Initiative: Marina Kaplan Project launched in June 2020 as an official project of the MBC Alliance which includes 32 nonprofits, 12 industry partners, and 30 individual patient advocates. The Marina Project has grown to include 35members with representation from industry, research institutions, and individual patients. Nearly one-third of the group is comprised of patients living with brain metastases or leptomeningeal disease (LMD). Disparities for Patients Living with B

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Pisani, P., G. Angeli, M. Krengli, and F. Pia. "Renal carcinoma metastasis to the parotid gland." Journal of Laryngology & Otology 104, no. 4 (1990): 352–54. http://dx.doi.org/10.1017/s0022215100112691.

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AbstractMetastatic tumours in major salivary glands are uncommon with a higher incidence of primary sites from the head and neck. The lungs and breast are the common primary sites, while metastases from the kidney are very rarely found. The authors describe a case of renal clear-cell carcinoma with metastastis to the parotid gland. The incidence of a metastasis in the parotid gland from a primary renal carcinoma, even if rare, should not be overlooked in making a correct differential diagnosis with acinic cell carcinoma and monomorphic clear cell adenoma.

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Kiyasu, Yoshiyuki, Ken Hayashi, Go Miyahara, and Makoto Narita. "Solitary Pancreatic Metastasis From Breast Matrix-Producing Carcinoma: A First Case Report." International Surgery 102, no. 7-8 (2017): 294–98. http://dx.doi.org/10.9738/intsurg-d-17-00064.1.

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Introduction: Breast matrix-producing carcinoma (MPC) is a rare histologic type. Pancreatic metastases from breast cancers are also rare. We report the first case of solitary pancreatic metastasis from breast MPC, treated with distal pancreatectomy. Case presentation: A 56-year-old woman presented with a 56-mm mass in her right breast and a swollen right axillary lymph node. Both lesions had characteristic early ring enhancement on dynamic magnetic resonance imaging (MRI). Tumor biopsy revealed MPC. She underwent total mastectomy and axillary clearance. On histopathologic examination, the tumo

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Hosonaga, Mari, Hideyuki Saya, and Yoshimi Arima. "Molecular and cellular mechanisms underlying brain metastasis of breast cancer." Cancer and Metastasis Reviews 39, no. 3 (2020): 711–20. http://dx.doi.org/10.1007/s10555-020-09881-y.

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Abstract Metastasis of cancer cells to the brain occurs frequently in patients with certain subtypes of breast cancer. In particular, patients with HER2-positive or triple-negative breast cancer are at high risk for the development of brain metastases. Despite recent advances in the treatment of primary breast tumors, the prognosis of breast cancer patients with brain metastases remains poor. A better understanding of the molecular and cellular mechanisms underlying brain metastasis might be expected to lead to improvements in the overall survival rate for these patients. Recent studies have r

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Valenza, Carmine, Francesca Maria Porta, Alessandra Rappa, et al. "Complex Differential Diagnosis between Primary Breast Cancer and Breast Metastasis from EGFR-Mutated Lung Adenocarcinoma: Case Report and Literature Review." Current Oncology 28, no. 5 (2021): 3384–92. http://dx.doi.org/10.3390/curroncol28050292.

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We present a case of a woman with epidermal growth factor receptor (EGFR)-mutated lung adenocarcinoma who received gefitinib for 2 years and obtained a partial response. The patient then developed liver metastasis and a breast lesion, displaying high estrogen receptor (ER) expression and harboring the same EGFR mutation. From the radiological studies, it was not possible to make a differential diagnosis between primary breast cancer and breast metastasis from lung cancer. After the removal of the breast nodule, thanks to the clinical history, radiology, and above all, molecular and immunohisto

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Yazdani, Akram, and Hossein Akbari. "Association of CA 15-3 and CEA with Liver Metastases in Patients with Breast Cancer." Current Cancer Therapy Reviews 16, no. 4 (2020): 332–36. http://dx.doi.org/10.2174/1573394716666191216112938.

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Objective: The liver is the second most common site of distant metastasis from breast cancer that is usually associated with poor prognosis and low quality of life in breast cancer patients. Therefore, the primary diagnosis of liver metastatic lesions in breast cancer patients is very important. In this study, the ability of biochemical markers CA153, CEA, and ALP to be used for prognostic liver metastasis in women with breast cancer was investigated. Methods: 306 women with breast cancer recorded between 2008 and 2012 were included. Serum concentrations of alkaline phosphatase (ALP), carcinog

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Welm, Alana L., Julie B. Sneddon, Carmen Taylor, et al. "The macrophage-stimulating protein pathway promotes metastasis in a mouse model for breast cancer and predicts poor prognosis in humans." Proceedings of the National Academy of Sciences 104, no. 18 (2007): 7570–75. http://dx.doi.org/10.1073/pnas.0702095104.

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A better understanding of tumor metastasis requires development of animal models that authentically reproduce the metastatic process. By modifying an existing mouse model of breast cancer, we discovered that macrophage-stimulating protein promoted breast tumor growth and metastasis to several organs. A special feature of our findings was the occurrence of osteolytic bone metastases, which are prominent in human breast cancer. To explore the clinical relevance of our model, we examined expression levels of three genes involved in activation of the MSP signaling pathway (MSP, MT-SP1, and MST1R)

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Bhandari, Virendra, Saadvik Raghuraman, Kanchan Singh, and Sweta Kaushik. "Orbital Metastasis as the Presenting Feature of Carcinoma Breast." Indian Journal of Cancer Education and Research 4, no. 2 (2016): 67–70. http://dx.doi.org/10.21088/ijcer.2321.9815.4216.5.

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Basaran, Recep, Mehmet Tiryaki, Dilek Yavuzer, Mustafa Efendioglu, Ece Balkuv, and Aydin Sav. "Spinal Intramedullary Metastasis of Breast Cancer." Case Reports in Medicine 2014 (2014): 1–3. http://dx.doi.org/10.1155/2014/583282.

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Objective.Breast cancer accounts for approximately one-third of all cancers in females. Approximately 8.5 % of all central nervous system metastases are located in the spinal cord. These patients have rapidly progressing neurological deficits and require immediate examination. The aim of surgery is decompression of neural tissue and histological evaluation of the tumor. In this paper, we present a case of breast cancer metastasis in thoracic spinal intramedullary area which had been partially excised and then given adjuvant radiotherapy.Case.A 43-year-old female patient with breast cancer for

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Srirajaskanthan, R., K. Desai, A. Jayaratnam, et al. "Uncommon sites for metastasis of neuroendocrine tumor in adults." Journal of Clinical Oncology 27, no. 15_suppl (2009): e15683-e15683. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.e15683.

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e15683 Background: Neuroendocrine tumours are relatively slow growing tumours. They often present with significant metastatic disease affecting liver, lymph nodes, lungs and bone. However tumour masses may be found at unusual/uncommon sites e.g. breast, orbital soft tissue and the heart raising the possibility of this being metastatic focus or presence of another primary tumour. Detection of these sites could have a significant impact on the available treatment options. Aim: to determine the most appropriate imaging modality and type of tumour metastases. Methods: We reviewed 300 consecutive c

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Critchley, Adam Charles, James Harvey, Michael Carr, and Obi Iwuchukwu. "Synchronous gastric and colonic metastases of invasive lobular breast carcinoma: case report and review of the literature." Annals of The Royal College of Surgeons of England 93, no. 5 (2011): e49-e50. http://dx.doi.org/10.1308/147870811x582800.

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Breast cancer is the most common malignancy in women and the main cause of cancer death in the UK. Gastrointestinal (GI) tract metastasis and carcinomatosis from primary breast cancer are rare but breast cancer is the second most common primary malignancy to metastasise to the GI tract after malignant melanoma. The metastatic patterns of invasive lobular carcinoma (ILC) and invasive ductal carcinoma (IDC) have been shown to differ considerably. Liver, lung and brain metastases are more common in IDC. Most series report a greater prediliction for lobular carcinoma to metastasise to the GI tract

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Brady, Claire, Richard Martin Bambury, Jodie E. Battley, et al. "Resection of breast cancer brain metastases: A single institution experience." Journal of Clinical Oncology 30, no. 15_suppl (2012): e11569-e11569. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.e11569.

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e11569 Background: Resection of a single brain metastasis (SBM) in metastatic cancer has been shown to improve overall survival (OS). A previously reported series from MD Anderson of breast cancer patients undergoing SBM resection reported a median overall survival of 19 months. We report our experience of SBM resection for breast cancer. Methods: Retrospective observational study of patients who underwent resection of SBM from breast cancer brain in a tertiary referral centre from 2000-2011. Results: 20 patients underwent SBM resection from 2000-2011. All patients received WBRT after surgery.

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Han, W., H. Kim, J. Lee, et al. "Value of preoperative staging of breast cancer patients using computed tomography to detect asymptomatic lung and liver metastasis." Journal of Clinical Oncology 27, no. 15_suppl (2009): 1105. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.1105.

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1105 Background: Preoperative clinical staging in breast cancer patients is important to determine the most appropriate treatment plans and to predict prognosis for individual patients. Identifying unexpected distant metastases in newly diagnosed breast cancer patients frequently alters initial treatment plans. Routine imaging studies to detect lung or liver metastasis is not indicated in patients with early and operable breast cancer. A recent study showed that routine use of chest radiograph and liver ultrasound does not provide much diagnostic benefit in early breast cancer patients. Method

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Solaini, Leonardo, Anna Bianchi, Luigi Filippini, Laura Lucini, Edda Simoncini, and Fulvio Ragni. "A Mammary Nodule Mimicking Breast Cancer." International Surgery 99, no. 3 (2014): 200–202. http://dx.doi.org/10.9738/intsurg-d-12-00019.1.

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Abstract Metastases to the breast from extramammary tumors are rare. Several clinical, radiologic, and histologic signs can help to distinguish metastases from breast primary tumors. In the present study, we present a case of a left-sided breast metastasis from renal cancer in a 44-year-old woman whose clinical presentation was a mammary nodule in the upper internal quadrant. The patient underwent quadrantectomy with sentinel lymph node biopsy. The histology revealed a clear cell carcinoma. On computed tomography scan a 5×8-cm left renal mass with pulmonary, liver, and intrapericardial nodules

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Oktay, Esin, Özlem Yersal, Nezih Meydan, Mehmet Sağıroğlu, Ömer Uyanık, and Sabri Barutca. "Nearly Complete Response of Brain Metastases from HER2 Overexpressing Breast Cancer with Lapatinib and Capecitabine after Whole Brain Irradiation." Case Reports in Oncological Medicine 2013 (2013): 1–4. http://dx.doi.org/10.1155/2013/234391.

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Trastuzumab treatment does not prevent intracranial seeding and is largely ineffective for established central nervous system metastasis in HER2 overexpressing breast cancer patients. Combination therapy of lapatinib and capecitabine may be an effective treatment option for brain metastasis of HER2-positive breast cancer. We report a patient with breast cancer overexpressing HER-2 where brain metastases were successfully treated with radiation and a combination of lapatinib and capecitabine.

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Cormio, Luigi, Francesca Sanguedolce, Giuseppe Di Fino, et al. "Asymptomatic Bladder Metastasis from Breast Cancer." Case Reports in Urology 2014 (2014): 1–3. http://dx.doi.org/10.1155/2014/672591.

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Introduction.Breast cancer is the most common nondermatologic cancer in women. Common metastatic sites include lymph nodes, lung, liver, and bone. Metastases to the bladder are extremely rare, with all reported cases presenting with urinary symptoms.Case Report.Herein, we report the first case of completely asymptomatic bladder metastasis from breast cancer, occasionally revealed, 98 months after the initial diagnosis of lobular breast carcinoma, by a follow-up computed tomography scanning showing thickening of left bladder wall and grade II left hydronephrosis. A positive staining for estroge

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Cavazzini, Giovanna, Francesco Colpani, Maurizio Cantore, et al. "Breast Metastasis from Gastric Signet Ring Cell Carcinoma, Mimicking Inflammatory Carcinoma. A Case Report." Tumori Journal 79, no. 6 (1993): 450–53. http://dx.doi.org/10.1177/030089169307900617.

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We report a case of breast metastasis of signet ring cell gastric cancer clinically presented as a primary inflammatory carcinoma. Metastases to the breast are uncommon; review of the literature demonstrated only 300 cases. The clinical and radiographic features of the metastatic lesion were unlike those reported in the literature. Although a primary signet ring cell breast carcinoma was described, the pathologic patterns of the breast lesion, here reported, lead us to conclude this was a metastasis and not another primary tumor.

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Zhao, F.-L., G.-D. Hu, X.-F. Wang, X.-H. Zhang, Y.-K. Zhang, and Z.-S. Yu. "Serum Overexpression of MicroRNA-10b in Patients with Bone Metastatic Primary Breast Cancer." Journal of International Medical Research 40, no. 3 (2012): 859–66. http://dx.doi.org/10.1177/147323001204000304.

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OBJECTIVE: Bone metastasis is a major complication of advanced breast cancer. The present prospective case—control study investigated the involvement of microRNA (miR)-10b in the development of bone metastasis arising from primary breast carcinoma. METHODS: Serum miR-10b concentrations were determined by quantitative real-time reverse transcription—polymerase chain reaction in 122 patients with breast cancer, with or without bone metastases, and 59 age-matched healthy control subjects. RESULTS: Serum miR-10b concentrations were significantly higher in patients with bone metastases than in pati

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RODRIGUES, Marcus Vinicius Rozo, Valdir TERCIOTI-JUNIOR, Luiz Roberto LOPES, João de Souza COELHO-NETO, and Nelson Adami ANDREOLLO. "BREAST CANCER METASTASIS IN THE STOMACH: WHEN THE GASTRECTOMY IS INDICATED ?" ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo) 29, no. 2 (2016): 86–89. http://dx.doi.org/10.1590/0102-6720201600020005.

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ABSTRACT Background: Breast cancer is the most common malignant neoplasm in the female population. However, stomach is a rare site for metastasis, and can show up many years after initial diagnosis and treatment of the primary tumor. Aim: Analyze a case series of this tumor and propose measures that can diagnose it with more precocity. Methods: Were analyzed 12 patients with secondary gastric tumors. Immunohistochemistry has demonstrated that primary tumor was breast cancer. We retrieved information of age, histological type, interval between diagnosis of the primary breast cancer and its meta

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Vona-Davis, Linda, David P. Rose, Vijaya Gadiyaram, et al. "Breast Cancer Pathology, Receptor Status, and Patterns of Metastasis in a Rural Appalachian Population." Journal of Cancer Epidemiology 2014 (2014): 1–9. http://dx.doi.org/10.1155/2014/170634.

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Breast cancer patients in rural Appalachia have a high prevalence of obesity and poverty, together with more triple-negative phenotypes. We reviewed clinical records for tumor receptor status and time to distant metastasis. Body mass index, tumor size, grade, nodal status, and receptor status were related to metastatic patterns. For 687 patients, 13.8% developed metastases to bone (n=42) or visceral sites (n=53). Metastases to viscera occurred within five years, a latent period which was shorter than that for bone (P=0.042). More women with visceral metastasis presented with grade 3 tumors com

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Li, Mao, Markus Schweiger, Ichiro Nakano, Daniel Ryan, Litia Carvalho, and Bakhos Tannous. "BSCI-16. Olfactory receptor 5B21 drives breast cancer metastasis." Neuro-Oncology Advances 3, Supplement_3 (2021): iii4. http://dx.doi.org/10.1093/noajnl/vdab071.015.

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Abstract Olfactory receptors (ORs), responsible for the sense of smell, play an essential role in physiological processes (even outside the nasal epithelium) and cancer. In breast cancer, however, the expression and role of ORs remain understudied. We examined the significance of ORs transcript abundance in breast cancer metastasis to different tissues including the brain, bone, and lung. While we found 20 OR genes to be differentially expressed in different metastasis versus primary tumor, OR5B21 displayed high relation with all metastases. Knockdown of OR5B21 significantly decreased the inva

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Davies, Timothy, Tarak Chouari, Christopher Ray, and Suzanne Elgammal. "Appendiceal adenocarcinoma with breast metastases." BMJ Case Reports 14, no. 5 (2021): e240808. http://dx.doi.org/10.1136/bcr-2020-240808.

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Malignant lesions of the vermiform appendix make up a rare subset of colorectal cancer. While colorectal cancer frequently metastasises to the liver, lung, regional lymph nodes and peritoneum, metastasis to the breast is extremely rare. Here, we describe the case of an 84-year-old woman who had the incidental finding of appendiceal adenocarcinoma following emergency laparoscopic appendectomy. She declined further operative or adjuvant treatment for her disease. She represented 1 year later with metastatic appendiceal adenocarcinoma disease to her left breast. A simple mastectomy for symptomati

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Tulotta, Claudia, and Penelope Ottewell. "The role of IL-1B in breast cancer bone metastasis." Endocrine-Related Cancer 25, no. 7 (2018): R421—R434. http://dx.doi.org/10.1530/erc-17-0309.

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Approximately 75% of patients with late-stage breast cancer will develop bone metastasis. This condition is currently considered incurable and patients’ life expectancy is limited to 2–3 years following diagnosis of bone involvement. Interleukin (IL)-1B is a pro-inflammatory cytokine whose expression in primary tumours has been identified as a potential biomarker for predicting breast cancer patients at increased risk for developing bone metastasis. In this review, we discuss how IL-1B from both the tumour cells and the tumour microenvironment influence growth of primary breast tumours, dissem

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Washam, Charity L., Stephanie D. Byrum, Kim Leitzel, Ali M. Suhail, Allan Lipton, and Larry J. Suva. "PTHrP(12-48) for the diagnosis of breast cancer bone metastasis." Journal of Clinical Oncology 30, no. 15_suppl (2012): e21039-e21039. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.e21039.

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e21039 Background: Bone metastasis of breast cancer significantly compromises patient morbidity and mortality. Currently, no reliable methods detect or predict patients at increased risk for developing bone metastasis. We utilized 3 independent cohorts of breast cancer patients to validate a highly discriminatory plasma-based proteomic profile that identifies breast cancer bone metastasis. The identity of the most discriminatory protein component identified was a parathyroid hormone-related protein fragment, PTHrP(12-48). Methods: Plasma samples collected from 21 breast cancer patients with cl

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Fukumura, Kazutaka, Xizeng Mao, Xingzhi Song, et al. "BSCI-12. COMPREHENSIVE GENOMIC ANALYSIS OF BRAIN METASTASES FROM MULTIPLE CANCER TYPES." Neuro-Oncology Advances 1, Supplement_1 (2019): i3. http://dx.doi.org/10.1093/noajnl/vdz014.010.

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Abstract PURPOSE: Brain metastases occur in approximately 8–10% of patients with cancer, and the incidence has increased over the past decades. The most common primary tumors responsible for brain metastases are lung cancer, melanoma, renal cell carcinoma (RCC), breast cancer and colorectal cancer. The precise mechanisms by which genomic and transcriptional abnormalities drive the formation of brain metastases remain unclear. Here, we conducted comprehensive genomic and transcriptional analysis with paired primary tumor tissue (or extracranial metastasis tissue) and brain metastasis tissue usi

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Hajjaji, Nawale, Mira Abbouchi, Lan Anh Nguyen, et al. "A novel proteomic mass spectrometry-based approach to reveal functionally heterogeneous tumor clones in breast cancer metastases and identify clone-specific drug targets." Journal of Clinical Oncology 38, no. 15_suppl (2020): e13063-e13063. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.e13063.

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e13063 Background: Breast cancer mortality is expected to rise by almost 30% by 2030 worldwide, mainly due to the occurrence of distant metastases. The development of drugs specifically targeted at tumor drivers has not yet curbed resistance to treatment, which prevents metastases curability. There is a need for new molecular approaches to tackle metastases complex biology, particularly tumor heterogeneity, a main determinant of resistance. The aim of this study was to use a proteomic mass spectrometry-based approach to reveal functionally heterogeneous’ tumor subpopulations in breast cancer m

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Hiller, David, and Quyen D. Chu. "CXCR4 and Axillary Lymph Nodes: Review of a Potential Biomarker for Breast Cancer Metastasis." International Journal of Breast Cancer 2011 (2011): 1–6. http://dx.doi.org/10.4061/2011/420981.

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CXCR4 is a 7-transmembrane G-protein chemokine receptor that allows for migration of hematopoietic cells from the bone marrow to the peripheral lymph nodes. Research has shown CXCR4 to be implicated in the invasion and metastasis of several cancers, including carcinoma of the breast. CXCL12 is the ligand for CXCR4 and is highly expressed in areas common for breast cancer metastasis, including the axillary lymph nodes. Axillary lymph nodes positive for breast carcinoma have been an important component of breast cancer diagnosis, treatment, and subsequent research. The goal of this paper is to a

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