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Journal articles on the topic 'Brine shrimp lethality: Brine shrimp lethality assay'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Sarah, Quazi Sahely, Fatema Chowdhury Anny, and Mir Misbahuddin. "Brine shrimp lethality assay." Bangladesh Journal of Pharmacology 12, no. 2 (2017): 5. http://dx.doi.org/10.3329/bjp.v12i2.32796.

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<p>Brine shrimp lethality assay is an important tool for the preliminary cytotoxicity assay of plant extract and others based on the ability to kill a laboratory cultured larvae (nauplii). The nauplii were exposed to different concentrations of plant extract for 24 hours. The number of motile nauplii was calculated for the effectiveness of the extract. It is a simple, cost effective and requires small amount of test material.</p><p><strong>Video Clip of Methodology</strong>:</p><p>Brine Shrimp Lethality Assay: 4 min 9 sec <a href="https://www.youtub

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D'Souza, Prashanth, Mundkinajeddu Deepak, Padmaja Rani, et al. "Brine shrimp lethality assay of Bacopa monnieri." Phytotherapy Research 16, no. 2 (2002): 197–98. http://dx.doi.org/10.1002/ptr.1001.

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MAHBOOB, A., S. GHAZALA, M. AKRAM, and S. M. ALI. "INVESTIGATION OF CYTOTOXIC ACTIVITY OF HYDROALCOHOLIC EXTRACT OF MEDICINAL PLANTS USING ARTEMIA SALINA (BRINE SHRIMP TEST)." Latin American Applied Research - An international journal 45, no. 4 (2015): 231–32. http://dx.doi.org/10.52292/j.laar.2015.403.

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Medicinal plants have been screened for their biological activity using Brine Shrimp (Artemia salina leach). Brine shrimp lethality test was used to investigate the cytotoxic activity of plant extracts. After 24 hour of treatment, the larvicidal activity was assessed on the base of percentage of larval mortality. The bioactivity of hydroalcoholic extracts of different parts of medicinal plants, at different concentrations (1-5000 µg/mL), was evaluated with the shrimp lethality assay. Lethality concentration (LC50) was obtained using probit analysis. Out of the 17 plants tested, Veratrum album

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Kane, S. R., S. V. Bhandari, and C. S. Magdum. "LC50 DETERMINATION OF EUPHORBIA THYMIFOLIA LINN BY BRINE SHRIMP LETHALITY ASSAY." INDIAN DRUGS 54, no. 05 (2017): 16–18. http://dx.doi.org/10.53879/id.54.05.10924.

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Brine shrimp larva has been used as a bioassay for a variety of toxic substances. Brine shrimp lethality assay has been applied to plant extracts in order to facilitate the isolation of biologically active compounds. This method is used for the determination of LC50 values of herbal extracts. In this study, the plants Euphorbia thymifolia Linn, which is reported in traditional literature for its anti-tumor activity, had been selected to test for brine shrimp lethality activity. Petroleum ether, diethyl ether, chloroform, ethyl acetate, acetone, methanol, aqueous and ethanolic extract were coll

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R. Hamidi, Mentor, Blagica Jovanova, and Tatjana Kadifkova Panovska. "Toxicological evaluation of the plant products using Brine Shrimp (Artemia salina L.) model." Macedonian Pharmaceutical Bulletin 60, no. 01 (2014): 9–18. http://dx.doi.org/10.33320/maced.pharm.bull.2014.60.01.002.

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Many natural products could serve as the starting point in the development of modern medicines because of their numerous biological and pharmacological activities. However, some of them are known to carry toxicological properties as well. In order to achieve a safe treatment with plant products, numerous research studies have recently been focused on both pharmacology and toxicity of medicinal plants. Moreover, these studies employed efforts for alternative biological assays. Brine Shrimp Lethality Assay is the most convenient system for monitoring biological activities of various plant specie

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Muhammad, Kamran Khan Muhammad Uzair Talal Shaheer Zeeshan Javaid Fahim ullah Muhammad Taufiq Ahmad Qazi Amir Ijaz. "EVALUATION OF CYTOTOXIC ACTIVITY OF DICHOLOROMETHANE (DCM) AND METHANOL (MEOH) EXTRACT OF ROOT BARK OF CAPPARIS DECIDUA." Indo American Journal of Pharmaceutical Sciences 04, no. 11 (2017): 4126–29. https://doi.org/10.5281/zenodo.1048962.

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The present study was conducted to evaluate the cytotoxic activity of different extracts of root bark of Capparis decidua (Capparidaceae). The root barks of Capparis decidua were collected from village Kirri khaisore Tehsil Pahar pur, Dera Ismail Khan; shade dried and ground into fine powder. The weighed plant material was then extracted with dichloromethane and methanol in triplicate for 72 hours by the process of successive maceration. The filtrate obtained was concentrated under reduced pressure at 30 °C using rotary evaporator. Brine shrimp lethality bioassays and MTT colorimetric assay we

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Ntungwe N, Epole, Eva M. Domínguez-Martín, Amilcar Roberto, et al. "Artemia species: An Important Tool to Screen General Toxicity Samples." Current Pharmaceutical Design 26, no. 24 (2020): 2892–908. http://dx.doi.org/10.2174/1381612826666200406083035.

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Medicinal plants are a good source of novel therapeutic drugs, due to the phytochemicals present. Artemia, commonly known as brine shrimp, is a tiny halophilic invertebrate belonging to class Crustacean, which plays an important role in saline aquatic and marine eco-systems. Besides its usage in aquaculture, it is also highly valued for its application in toxicity detection and it is used in areas such as Ecology, Physiology, Ecotoxicology, Aquaculture and Genetics. Furthermore, Artemia based lethality assay (brine shrimp lethality assay, BSLA) is rapid, convenient and low cost. Presently, bri

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Wangensteen, Helle, Mahiuddin Alamgir, Sultana Rajia, Trine J. Meza, Anne Berit Samuelsen, and Karl E. Malterud. "Cytotoxicity and Brine Shrimp Lethality of Rotenoids and Extracts from Sarcolobus globosus." Natural Product Communications 2, no. 8 (2007): 1934578X0700200. http://dx.doi.org/10.1177/1934578x0700200810.

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The present study was performed to examine the brine shrimp toxicity and cytotoxic effect of the mangrove plant Sarcolobus globosus. The Et2O and EtOAc extracts were toxic to brine shrimp larvae (LC50 = 1.6 and 4.0 μg/mL) and Caco-2 cells (IC50 = 6.7 and 21.2 μg/mL). Three rotenoids isolated from S. globosus, tephrosin, sarcolobin and 12a-hydroxyrotenone, showed high toxicity in the brine shrimp assay with LC50 values of 2.2, 2.8 and 1.9 μM, respectively.

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Azeez, Sekinat Okikiola, Rachael Aderonke Ayo-Lawal, Idowu Julius Olawuni, and Olubukola Grace Abraham. "Evaluation of the bio-toxicity and cytogenetic effects of methanolic leaf extract of Heliotropium indicum L." International Journal of Biological and Chemical Sciences 14, no. 1 (2020): 1–10. http://dx.doi.org/10.4314/ijbcs.v14i1.1.

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Heliotropium indicum L. has been shown to be very important in traditional healing medicine. However, many reports have indicated that the toxicity is not unconnected with pharmaceutical properties. This study therefore investigated the cytotoxic, genotoxic and biotoxic activities of methanolic leaf extract of H. indicum using Brine Shrimp lethality assay. The results revealed that the leaf extract of H. indicum showed lethality against the Brine Shrimps nauplii. The highest mortality was recorded at a concentration of 1000 μg/ml. The LC50 value of the Brine Shrimps mortality of the extract wa

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Guaralde, Alailton Dos Reis, Daniela Almeida de Souza, Celso Luiz Possas Guimarães Júnior, et al. "An Artemia franciscana bioassay for the monitoring of lipophilic phycotoxins in marine bivalve mollusc cultures: An alternative to screening testing?" Ambiente e Agua - An Interdisciplinary Journal of Applied Science 15, no. 5 (2020): 1. http://dx.doi.org/10.4136/ambi-agua.2549.

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In Brazil, malacoculture is developed mainly in the state of Santa Catarina, followed by São Paulo and Rio de Janeiro. In the course of the development of Brazilian mariculture, legislation has addressed the sanitary requirements necessary for bivalve commercialization. However, monitoring phycotoxins is a challenge, due to often costly reference methods. In this context, this study evaluated the use of alternative ecotoxicological and bioanalytical methods using Artemia franciscana (brine shrimp) lethality assessments. The results confirm that, although correlations between the reference mous

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Achakzai, Jahangir Khan, Muhammad Anwar Panezai, Basira Akhtar, et al. "In Vitro Anti-Inflammatory, Anticancer (MCF-7, 3T3, and HeLa Cell Lines), and Brine Shrimp Lethality Assay and FTIR Analysis of the Extract and Fractions of the Whole Plant of Heliotropium europaeum." Mediators of Inflammation 2020 (February 1, 2020): 1–14. http://dx.doi.org/10.1155/2020/5056897.

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In this study, anti-inflammatory, anticancer, brine shrimp lethality, and FTIR studies were evaluated. The oxidative burst assay using the chemiluminescence technique, MTT assay, brine shrimp lethality assay, and FTIR analysis were the methods used for the evaluation of anti-inflammatory, anticancer, brine shrimp lethality, and FTIR studies, respectively. The whole-plant butanol fraction of Heliotropium europaeum (WBFHE) showed anti-inflammatory activity on ROS having IC5014.7±2.5 while the extract and other fractions of the whole plant of Heliotropium europaeum exhibited no anti-inflammatory

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Wakawa, Henry Yusufu, Fasihuddin Badrudin Ahmad, Zaini Bin Assim, and Umaru Isaac John. "Brine Shrimp Cytotoxic Activity of Morinda elliptica Leaves and Root Crude Extracts." Borneo Journal of Resource Science and Technology 7, no. 1 (2017): 43–46. http://dx.doi.org/10.33736/bjrst.390.2017.

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This survey was conducted to test for in vivo Brine Shrimp Lethality Assay (BSLA) of Morinda elliptica leaves and root extract after successive maceration in four solvents (n-hexane, dichloromethane (DCM) ethyl acetate and methanol) and cytotoxicity was evaluated in terms of LC50 (lethality concentration). 10 nauplii were placed in different concentrations (in three replicates each) of the plant extracts, after 24 hours the surviving brine shrimp larvae were counted and LC50 was assessed. The result of the survey showed a concentration dependent increment in mortality rate of the brine shrimp

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Khatun, Rafeza, Iffat Hasnin, Anamul Haque, and Md Aziz Abdur Rahman. "Comparative Cytotoxicity of Selected Mikania species using Brine Shrimp Lethality Bioassay and Sulforhodamine B (SRB) Assay." Bangladesh Pharmaceutical Journal 24, no. 1 (2021): 11–16. http://dx.doi.org/10.3329/bpj.v24i1.51630.

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This study aims to assess the comparative cytotoxic activity of the ethanolic extract of Mikania cordata (MC), Mikania micrantha (MM) and Mikania scandens (MS) (Family: Asteraceae) using brine shrimp lethality bioassay and colorimetric sulforhodamine B assay method. In SRB assay, A549 human lung carcinoma, SK-Mel-2 skin melanoma and B16F1 mouse melanoma cell lines were used. In brine shrimp assay, the LC50 for MC, MM, MS and vincristine were found to be 29.04, 15.84, 32.35, and 1.2 μg/ml, respectively. The results indicate that all the Mikania species showed moderate lethality against nauplii.

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Suneka, S., and T. Manoranjan. "Brine shrimp lethality assay with selected medicinal plants extracts." Vingnanam Journal of Science 16, no. 2 (2021): 14. http://dx.doi.org/10.4038/vingnanam.v16i2.4201.

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Waghulde, Sandeep, Mohan K. Kale, and VijayR Patil. "Brine Shrimp Lethality Assay of the Aqueous and Ethanolic Extracts of the Selected Species of Medicinal Plants." Proceedings 41, no. 1 (2019): 47. http://dx.doi.org/10.3390/ecsoc-23-06703.

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The present study was conducted to test for in vivo Brine Shrimp Lethality Assay (BSLA) of the Aqueous and ethanolic extracts of Annona reticulata with Allium fistolisum and Brassica oleraceaeand correlate cytotoxicity results with known pharmacological activities of the plants. Cytotoxicity was evaluated in terms of LC50 (lethality concentration). Ten nauplii were added into three replicates of each concentration of the plant extract. After 24 h the surviving brine shrimp larvae were counted and LC50 was assessed. Results showed that the extracts of Annona reticulata with Allium fistolisumand

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Azad, AK, WS Azizi, AFH Ismail, Syed Atif Abbas, Jalal Uddin, and Zubair Khalid Labu. "Phytochemical and Toxicity Evaluation of Traditional Herb: Lagerstroemia speciosa L. (Banaba) by MCF-7 Cell Line and Brine Shrimp Lethality Bioassay." Bangladesh Pharmaceutical Journal 22, no. 1 (2019): 45–49. http://dx.doi.org/10.3329/bpj.v22i1.40072.

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The main objective of this study was to determine the cytotoxicity of crude extract of the leaves of Lagerstroemia speciosa (Banaba). In vitro MCF-7 cell line and in vivo brine shrimp lethality bioassay methods were followed to investigate the cytotoxicity of the selected sample. In this study, the qualitative phytochemical assessment demonstrated the presence of alkaloids, carbohydrate, glycosides, saponins, terpenes, steroids, phenols and flavonoids in Banaba extract. Moreover, the present findings revealed the non-cytotoxic nature of L. speciosa leaves extract on both MTT-assay and brine sh

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Owolarafe, Tajudeen Alowonle, and Salawu Kailani. "Identification and Toxicity Profiling of Column Fractions of Ethanol Leaf Extract of Ziziphus mauritiana." Biology, Medicine, & Natural Product Chemistry 12, no. 2 (2024): 651–62. http://dx.doi.org/10.14421/biomedich.2023.122.651-662.

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Different plants may contain varying amounts of phytochemicals and also different degrees of toxicity. This study aimed to evaluate the phytochemicals present in the most active column fraction of ethanol leaf extract of the Ziziphus mauritiana plant and their toxic effects using brine shrimp lethality assay and animal model. Crude ethanol extract was obtained by maceration while fraction was achieved using a column chromatography experiment. Toxicity was evaluated with brine shrimp lethality assay and albino rat’s models while characterization was achieved with liquid chromatography-mass spec

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Ndossi, Barakaeli, and Mhuji Kilonzo. "Brine Shrimp Lethality Assay of Selected Medicinal Plants in Tanzania." Journal of Complementary and Alternative Medical Research 5, no. 3 (2018): 1–6. http://dx.doi.org/10.9734/jocamr/2018/41239.

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Granger, Melanie, Emilie Samson, Severine Sauvage, et al. "Bioactivity of extracts of Centaurea polyclada dc. (Asteraceae)." Archives of Biological Sciences 61, no. 3 (2009): 447–52. http://dx.doi.org/10.2298/abs0903447g.

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The free radical-scavenging property, antibacterial activity, and brine shrimp toxicity of n-hexane, dichloromethane (DCM), and methanol (MeOH) extracts of Centaurea polyclada, an endemic Turkish species, were assessed using the 2,2-diphenyl-1-picryl-hydrazyl (DPPH) assay, the resazurin microtiter plate-based assay, and the brine shrimp lethality assay, respectively. The DCM and MeOH extracts of C. polyclada exhibited free radical-scavenging ability with RC50 values 1.17 and 0.015 mg/mL, respectively. Among solid-phase extraction fractions of the MeOH extract, the fraction eluted with 60% MeOH

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L, Dolnar, J., and Zodape, G. V. "Assessment of Acute Oral Toxicity, Shrimp Lethality Assay, and Histopathological Effects of Crude Extract of Chiropsoides buitendijki in Female Sprague Dawley Rats." Saudi Journal of Medical and Pharmaceutical Sciences 11, no. 02 (2025): 109–16. https://doi.org/10.36348/sjmps.2025.v11i02.006.

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This study evaluated the acute oral toxicity of a crude extract of Chiropsoides buitendijki in female Sprague-Dawley rats and its toxic effects in brine shrimp (Artemia salina). Rats were treated with the extract for 14 days, and no clinical signs of intoxication, lethality, or significant changes in body weight, food intake, or behavior were observed. The LD50 value for the rats was determined to be greater than 2000 mg/kg body weight. In brine shrimp lethality assays, the LC50 was calculated to be 20.89 µg/mL. Histological analysis of organs such as the liver, kidney, lungs, brain, spleen, o

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Zhivikj, Zoran, Kristina Shutevska, Ana Marija Bajatovska, et al. "Cytotoxic screening of selected Cannabis cultivars using brine shrimp lethality assay." Macedonian Pharmaceutical Bulletin 68, no. 03 (2022): 351–52. http://dx.doi.org/10.33320/maced.pharm.bull.2022.68.03.169.

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Y., Wakawa H., Prof D. R., and Fasihuddin B. A. "BRINE SHRIMP LETHALITY BIOASSAY OF ABRUS PRECATORIUS (LINN) LEAVES AND ROOT EXTRACT." International Journal of Pharmacy and Pharmaceutical Sciences 9, no. 1 (2016): 179. http://dx.doi.org/10.22159/ijpps.2017v9i1.15057.

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<p><strong>Objective: </strong>The present study was conducted to test for <em>in vivo</em> Brine Shrimp Lethality Assay (BSLA) of <em>Abrus precarious</em><em> </em>leaves and root extracts after successive maceration in four solvents (n-hexane, dichloromethane (DCM) ethyl acetate and methanol) and correlate cytotoxicity results with known pharmacological activities of the plant.</p><p><strong>Methods: </strong>Cytotoxicity was evaluated in terms of LC<sub>50</sub> (lethality concentration), 10 nauplii w

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Akula, Sowjanya, and Gubbiya Shiva Kumar. "In-vivo Toxicity Profile of 2-Butyl-3-(3, 5-Diiodo-4-Hydroxybenzoyl) Benzofuran on Different Experimental Models." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 14, no. 02 (2024): 932–37. http://dx.doi.org/10.25258/ijddt.14.2.49.

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The anti-cancer properties of 2-butyl-3-(3, 5-Diiodo-4-Hydroxybenzoyl) benzofuran have been determined in earlier in-vitro studies, but safety and efficacy still need to be resolved. This research investigates the acute oral toxicity of 2-butyl-3-(3, 5-diiodo-4-hydroxybenzoyl) benzofuran on female Wistar rats, zebrafish, and brine shrimp. The present study was conducted on rats to evaluate the compound acute oral toxicity, following the protocols established by the Organization for Economic Cooperation and Development (OECD) 423. After 14 days of duration, histopathological changes were observ

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Janakiraman, Dayana, and Parameswari Somasundaram. "ACTIVE PHENOLIC CONSTITUENTS AND BRINE SHRIMP LETHALITY ASSAY OF HYDROALCOHOLIC EXTRACT OF Plectranthus amboinicus." Asian Journal of Pharmaceutical and Clinical Research 10, no. 2 (2017): 186. http://dx.doi.org/10.22159/ajpcr.2017.v10i2.15115.

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Objective: Plectranthus amboinicus, (PA) leaves contain pharmaceutically important phyto constituents that attribute to greater medicinal values. The purpose of the present study was to investigate the active principles present in the potent Hydroalcoholic extract of P.amboinicus and brine shrimp lethality studies to understand the toxicity profile of PA.Methods: An approach towards High performance liquid chromatography (HPLC) screening of Hydroalcoholic extract of P.amboinicus and selective partitioning using various solvents such as Hexane, chloroform, ethylacetate and butanol were performe

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S. Dharmaraj Santhosam, P.Selvam, and Abhinandan Danodia. "IN-VITRO ANTI TUMOUR AND BRINE SHRIMP LETHALITY ASSAY OF ABRUS PRECATORIUS SEEDS." Tropical Journal of Pharmaceutical and Life Sciences 10, no. 1 (2023): 01–10. https://doi.org/10.61280/tjpls.v10i1.114.

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Abrus precatorius seeds are generally called Crab's eye seeds. The research work aims to determine the In-vitro Anticancer and the Brine shrimp lethality assay for the methanolic crude extract CMME and its isolated compounds CMME I, CMME II, and CMME III. The methanolic crude extract was prepared by the maceration method for 7 days. The compounds from the crude extract were isolated by column chromatography using silica gel 60-120 mesh as the adsorbent. The isolated compounds are further purified by Thin Layer Chromatography. The In-vitro anticancer activity of CMME and its isolated compounds

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Andini, Ary, Endah Prayekti, Devyana Dyah Wulandari, and Ersalina Nidianti. "CYTOTOXICITY ASSAY USING BRINE SHRIMP LETHALITY TEST ON COLLAGEN-CHITOSAN WOND DRESSING STERILIZED BY ULTRAVIOLET LIGHT." Indonesian Journal of Medical Laboratory Science and Technology 2, no. 1 (2020): 21–26. http://dx.doi.org/10.33086/ijmlst.v2i1.1467.

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Collagen gives a moist state on the wound area to accelerate the wound healing process. Chitosan is a polymer as known as non-toxic, antibacterial, antifungal, biodegradable, and biocompatible materials. Combination of collagen and chitosan expected to be the best biomaterials as a wound dressing for the healing process. The study aimed to determine cytotoxicity assay on collagen-chitosan wound dressing sterilized by ultraviolet (UV) Light using Brine Shrimp Lethality Test (BSLT) method. The test groups were divided into K0, K1, K2, and K3 groups. K0 contained pure chitosan as a control group,

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Riasari, Hesti, Yessi Febriani, and Winda A. Nurfauziah. "Toxicity Assay of Fermented Artocarpus altilis Leaves Using Brine Shrimp Lethality Test." Pharmacology and Clinical Pharmacy Research 4, no. 2 (2019): 46. http://dx.doi.org/10.15416/pcpr.v4i2.24525.

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Fermented Artocarpus altilis leaves contains phenolic compound that has pharmacological activity. Differences in fermentation method, i.e., aerobic and anaerobic fermentation might change its characteristics and biological activity. The purpose of this study was to compare toxicity properties between aerobically and anaerobically fermented Artocarpus altilis leaves using brine shrimp lethality (BSL) test. Both types of fermented leaves were cold extracted using ethanol solvent (1:6) for 3 x 24 hours. Phytochemical screening was then performed to examine the presence of secondary metabolite com

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Popovici, Patriciu Constantin, Viorel Robert Ancuceanu, Tudorel Octavian Olaru, Cristina-Silvia Stoicescu, and Mihaela Dinu. "Toxicity Assessment of Nephrolepis exaltata (L.) Schott, Fam. Nephrolepidaceae." Acta Biologica Marisiensis 1, no. 1 (2018): 27–36. http://dx.doi.org/10.2478/abmj-2018-0004.

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Abstract The fern Nephrolepis exaltata (L.) Schott, fam. Nephrolepidaceae, has little traditional medicinal use. In order to estimate its potential safety, in the present study we have investigated the phytotoxicity (on Triticum aestivum L.) and toxicity on brine shrimp of extracts from plants grown hydroponically. The species identity was confirmed by macroscopic and microscopic examinations on rhizomes, rachises, pinnae and runners, using bright field and fluorescent microscopy. Biological assays were performed on aqueous and ethanol solutions of the fronds. The brine shrimp lethality assay

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Waghulde, Sandeep, Ashwini Bhoir, Jyoti Gholap, Varsha Patil, Mohan K. Kale, and Vijay R. Patil. "Cumulative Effect of the Aqueous and Ethanolic Extracts of Annona Reticulate and Allium Sativumon Brine Shrimp Lethality Assay." Proceedings 41, no. 1 (2019): 36. http://dx.doi.org/10.3390/ecsoc-23-06698.

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The present study was conducted to test for in vivo Brine Shrimp Lethality Assay (BSLA) of the Aqueous and ethanolic extracts Annona reticulate Linn. and Allium sativumand correlate cytotoxicity results with known pharmacological activities of the plants. Cytotoxicity was evaluated in terms of LC50 (lethality concentration). Ten nauplii were added into three replicates of each concentration of the plant extract. After 24 h the surviving brine shrimp larvae were counted and LC50 was assessed. Results showed that the presence of alkaloids, tannins, and flavonoids could be accounted for its cytot

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Uddin, ABM Helal, and Abul Kalam Azad. "Phytochemical and Cytotoxicity Evaluation of Lagerstroemia speciosa (L.) Leaves Extract by MCF-7 Cell Line and Brine Shrimp Lethality Bioassay." International Journal of Drug Delivery Technology 10, no. 01 (2020): 40–44. http://dx.doi.org/10.25258/ijddt.10.1.6.

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This study aimed to investigate the cytotoxicity of Lagerstroemia speciosa (L.) leaves crude extract. It has been reported to show various bioactivities. The phytochemical screening of the extract has been carried qualitatively. The cytotoxic effect was determined through in vitro MTT assay of MCF-7 cell line, and brine shrimp lethality bioassay. The presence or absence of alkaloid, carbohydrate, glycoside, saponin, terpene, steroid, phenol, and flavonoid in the extract was determined through the qualitative tests. The extract showed cell viability of 100% (1.95–3.9 μL/mL), 96% (1.95 μL/mL), ≈

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Bandara, Kumudu R. V., Chayanika Padumadasa, and Dinithi C. Peiris. "Potent antibacterial, antioxidant and toxic activities of extracts from Passiflora suberosa L. leaves." PeerJ 6 (May 30, 2018): e4804. http://dx.doi.org/10.7717/peerj.4804.

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Passiflora suberosa L. belonging to the family Passifloraceae is an important medicinal plant used in traditional medicinal system in Sri Lanka to treat diabetes, hypertension and skin diseases. We extracted P. suberosa leaves under reflux conditions using different solvents (hexane, chloroform, methanol and water), then subjected to phytochemical screening. Alkaloids, flavonoids and saponins and saponins and anthraquinones were present in hexane and chloroform extracts. Alkaloids, unsaturated sterols, triterpenes, saponins, flavonoids and tannins were observed in both methanol and aqueous ext

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Vijayalakshmi, R., N. Ambalavanan, S. Rajesh Kumar, Jaideep Mahendra, Uma Sudhakar, and Tharani Munusamy. "Comparative analysis of antimicrobial efficacy and cytotoxicity of Terminalia arjuna bark extract mediated zinc oxide nanoparticles (ZnONPs) and selenium nanoparticles (SeNPs): An in-vitro study." IP International Journal of Periodontology and Implantology 9, no. 4 (2024): 188–94. https://doi.org/10.18231/j.ijpi.2024.039.

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This study provides an in-depth comparative analysis of the antimicrobial efficacy and cytotoxic effects of -mediated Selenium Nanoparticles (TA-SeNPs) and Zinc Oxide Nanoparticles (TA-ZnONPs) in the context of chronic periodontitis. The well diffusion assay and Brine Shrimp Lethality Assay were employed to assess antibacterial efficacy and cytotoxicity, respectively. The aim of the studyis to contribute to the understanding of the potential applications and safety considerations associated with green-synthesized ZnONPs and SeNPs as a local drug delivery agent in the treatment of chronic perio

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Bajatovska, Ana Marija, Zoran Zhivikj, Kristina Shutevska, et al. "Toxicity screening of weight loss tea products by Brine Shrimp Lethality Assay." Macedonian Pharmaceutical Bulletin 69, no. 03 (2023): 259–60. http://dx.doi.org/10.33320/maced.pharm.bull.2023.69.03.127.

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Sayyad, F. J., and G. H. Wadkar. "DETERMINATION OF ANTI-BACTERIAL ACTIVITY AND IN VITRO CYTOTOXIC ACTIVITY USING BRINE SHRIMP LETHALITY ASSAY OF CAESALPINIA BONDUCELLA LINN EXTRACTS." INDIAN DRUGS 54, no. 03 (2017): 19–22. http://dx.doi.org/10.53879/id.54.03.10850.

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Brine shrimp lethality assay is an important tool for preliminary assessment of cytotoxicity of herbal drugs. This method is used for the determination of LC50 values of herbal extracts. The root bark of Caesalpinia bonducella, which is reported in traditional literature for its anti-tumour activity, had been selected to test for brine shrimp lethality activity and antibacterial potentialities by Agar well diffusion method against gram-positive and gram-negative bacteria at concentrations of 150 and 300 μg/mL. Ciprofloxacin (100 μg/mL) was used as the standard drug. Present study shows that th

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Kumarasamy, Yashodharan, Philip J. Cox, Marcel Jaspars, Lutfun Nahar, and Satyajit D. Sarker. "Bioactivity of Hirsutanolol, Oregonin and Genkwanin, Isolated from the Seeds of Alnus Glutinosa (Betulaceae)." Natural Product Communications 1, no. 8 (2006): 1934578X0600100. http://dx.doi.org/10.1177/1934578x0600100808.

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The antibacterial and free radical scavenging activity, and the general toxicity of two diarylheptanoids, hirsutanolol (1) and oregonin (2), and a flavonoid, genkwanin (3), isolated from the methanol extract of the seeds of Alnus glutinosa, were assessed by the 96 well-based serial dilution antibacterial assay using resazurin as an indicator of cell growth, the DPPH assay, and the brine shrimp lethality assay, respectively.

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Shiono, Yoshihito, Yumi Seino, Takuya Koseki, Tetsuya Murayama, and Ken-ichi Kimura. "Antarones A and B, Two Polyketides from an Endophytic Penicillium antarcticum." Zeitschrift für Naturforschung B 63, no. 7 (2008): 909–14. http://dx.doi.org/10.1515/znb-2008-0716.

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Two new polyketides, antarones A and B, were isolated from the endophytic fungus Penicillium antarcticum. Their structures were determined by spectroscopic methods. Their general toxicity and cytotoxicity were evaluated, respectively, by brine shrimp lethality and cytotoxicity assay with human cancer cell lines. Neither antarones A nor B exhibited activity at the concentration of 100 μM.

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Dey, Sanjoy Chandra, Mohammd Firoz Khan, Mohammad S. Rahman, and Mohammad A. Rashid. "Preliminary Free Radical Scavenging, Brine Shrimp Lethality, Antimicrobial and Thrombolytic Activities of Aganosma dichotoma (Roth) K. Schum." Bangladesh Pharmaceutical Journal 17, no. 2 (2015): 177–81. http://dx.doi.org/10.3329/bpj.v17i2.22337.

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Bangladesh is a good repository of natural products. Numerous plants are available to facilitate the traditional treatments. Proper scientific evaluations are essential to explore the plant derived drugs. With this view, the crude methanol extract of leaves of Aganosma dichotoma (Roth) K. Schum. and its Kupchan fractions were screened for free radical scavenging, brine shrimp lethality, antimicrobial and thrombolytic activities. Among all extractives, the chloroform soluble fraction demonstrated the highest free radical scavenging activity with IC50 value 18.21 ?g/ml. Moreover, the chloroform

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Carević, Tamara, Marina Kostić, Biljana Nikolić, Dejan Stojković, Marina Soković, and Marija Ivanov. "Hesperetin—Between the Ability to Diminish Mono- and Polymicrobial Biofilms and Toxicity." Molecules 27, no. 20 (2022): 6806. http://dx.doi.org/10.3390/molecules27206806.

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Hesperetin is the aglycone of citrus flavonoid hesperidin. Due to the limited information regarding hesperetin antimicrobial potential and emerging need for novel antimicrobials, we have studied its antimicrobial activity (microdilution assay), antibiofilm activity with different assays in two models (mono- and polymicrobial biofilm), and toxicity (MTT and brine shrimp lethality assays). Hesperetin inhibited growth of all Candida isolates (minimal inhibitory concentration, MIC, 0.165 mg/mL), while it’s inhibitory potential towards Staphylococcus aureus was lower (MIC 4 mg/mL). Hesperetin (0.16

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Solomon, G. Olubunmi, O. Martha Ahmadu, and E. Esther Okogbe. "Cytotoxicity Screening and Invitro Antioxidant Potential of NEWBOULDIA LAEVIS Leaf Extract." International Journal of BioSciences, Agriculture and Technology (IJBSAT) ISSN: 0975 - 4539 10, no. 3 (2019): 13–20. https://doi.org/10.5281/zenodo.3385737.

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Cytotoxicity Screening and Invitro Antioxidant Potential of NEWBOULDIA LAEVIS Leaf Extract Solomon , G. Olubunmi; Ahmadu, O. Martha; Okogbe, E. Esther Bioresources Development Centre, Odi, National Biotechnology Development Agency, Abuja, Nigeria solomon.olubunmi@yahoo.com, martha_ahmadu@yahoo.com, okogbeenifo@gmail.com  IJBSAT (2019), 10(3):13-20 Abstract This study was aimed at determination of the phenolic composition of phenolic, antioxidant activity and cytotoxicity Newbouldia laevis leaf extract to brine shrimps (Artemia salina). Extracts from the leaves of the plant was subjected t

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Muaja, Arter Dein, Harry S. J. Koleangan, and Max R. J. Runtuwene. "Uji Toksisitas dengan Metode BSLT dan Analisis Kandungan Fitokimia Ekstrak Daun Soyogik (Saurauia bracteosa DC) dengan Metode Soxhletasi." Jurnal MIPA 2, no. 2 (2013): 115. http://dx.doi.org/10.35799/jm.2.2.2013.3000.

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Penelitian ini bertujuan untuk mengetahui toksisitas dari ekstrak daun soyogik menggunakan metode Brine Shrimp Lethality Test (BSLT) dan menentukan kandungan fitokimia daun soyogik (Saurauia bracteosa DC). Ekstrak dibuat dengan cara soxhletasi menggunakan pelarut metanol. Uji toksisitas dilakukan dengan menggunakan larva udang Artemia salina Leach yang berumur 48 jam. Efek toksik ekstrak diidentifikasi dengan presentase kematian larva udang menggunakan analisis probit (LC50). Kandungan fitokimia meliputi fenolik, flavonoid dan tanin. Penelitian menunjukkan ekstrak daun soyogik bersifat toksik

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Sarker, Satyajit, Lutfun Nahar, Srikanth Gujja, Shazi Begum, and Sezgin Celik. "Bioactivity of Centaurea persica boiss. (Asteraceae)." Archives of Biological Sciences 64, no. 2 (2012): 517–23. http://dx.doi.org/10.2298/abs1202517s.

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The free-radical-scavenging property, antibacterial activity and brine shrimp toxicity of petroleum ether (PE), dichloromethane (DCM) and methanol (MeOH) extracts of Centaurea persica, a Turkish medicinal plant, were assessed using the 2,2-diphenyl-1-picryl-hydrazyl (DPPH) assay, the resazurin microtiter plate based assay, and the brine shrimp lethality assay, respectively. Additionally, the disc diffusion assay was also used to assess antibacterial activity. Only the MeOH extract of C. persica exhibited a significant free-radical-scavenging property in the DPPH assay, with an RC50 value of 0.

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Abbasi, Anham Shahid, Qazi Najam-Us-Saqib, Atta-Ur-Rehman, and Nisar-Ur-Rahman. "Phytochemical analysis and cytotoxicity evaluation of flowering buds of Bauhinia variegata L." Herba Polonica 67, no. 3 (2021): 27–36. http://dx.doi.org/10.2478/hepo-2021-0013.

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Summary Introduction: Bauhinia variegata is used in traditional medicine in Pakistan. Objective: The present study was designated to analyze phytochemical screening and cytotoxicity assay of crude aqueous and methanol extracts of flowering buds of Bauhinia variegata. Methods: Qualitative and quantitative phytochemical screening of both extracts were performed by using standard protocols while brine shrimp lethality assay was conducted for cytotoxicity analysis of both extracts. Results: The highest levels of phenolics, flavonoids and terpenoids were observed in methanol extract with respective

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Andini, Ary, Ersalina Nidianti, and Endah Prayekti. "Cytotoxicity Assay of Chitosan-Collagen Wound Dressing using Brine Shrimp Lethality Test Methods." Biomedika 13, no. 1 (2020): 9–14. http://dx.doi.org/10.31001/biomedika.v13i1.680.

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Fatope, M. O., H. Ibrahim, and Y. Takeda. "Screening of Higher Plants Reputed as Pesticides Using the Brine Shrimp Lethality Assay." International Journal of Pharmacognosy 31, no. 4 (1993): 250–54. http://dx.doi.org/10.3109/13880209309082949.

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Mario, Mario, Puspa Dewi Lotulung, Gian Primahana, Sylvia Rizky Prima, and Muhammad Hanafi. "Synthesis and cytotoxicity assay using Brine Shrimp Lethality Test of Cinchonidine Isobutyrate Ester." Jurnal Kimia Terapan Indonesia 19, no. 1 (2017): 29–35. http://dx.doi.org/10.14203/jkti.v19i1.328.

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This research was aimed to synthesize cinchonidine isobutyrate ester and conduct a preliminary assay for anticancer agent using cytotoxicity assay to Artemia salina Leach larva, or also known as brine shrimp lethality test (BSLT). Cinchonidine, a compound that has quinoline rings and quiniclidine ring, is a quinine analogue and stereoisomer of cinchonine. Cinchonidine is predicted to have anticancer activity. Synthesized ester was aimed to gain higher lipophilicity. Higher lipophilicity makes it easier for the compund to pass through cell membrane. The esterification process used DMAP as a cat

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Lumor, Stephen E., Francisco Diez-Gonzalez, and Theodore P. Labuza. "Detection of Warfare Agents in Liquid Foods Using the Brine Shrimp Lethality Assay." Journal of Food Science 76, no. 1 (2011): T16—T19. http://dx.doi.org/10.1111/j.1750-3841.2010.01966.x.

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Zani, C. L., P. P. G. Chaves, R. Queiroz, et al. "Brine shrimp lethality assay as a prescreening system for anti-Trypanosoma cruzi activity." Phytomedicine 2, no. 1 (1995): 47–50. http://dx.doi.org/10.1016/s0944-7113(11)80048-6.

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Mustapha, R. K., A. M. Nafisatu, Magaji A. S, et al. "Toxicity Studies and in vivo Antiplasmodial Evaluation of Leaf and Stem Bark Extracts of Terminalia avicennioides." Saudi Journal of Medical and Pharmaceutical Sciences 9, no. 08 (2023): 546–52. http://dx.doi.org/10.36348/sjmps.2023.v09i08.008.

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Malaria is one of the most serious infectious diseases found in the tropics and subtropics. P. falcifarum resistance to almost all anti-malarial drugs has necessitated the search for anti-malarial compounds. The aim of this study is to investigate the antiplasmodial effects of crude leaf and stem bark extracts of T. avicennioides, a plant utilized by traditional healers in Northern Nigeria to treat malaria and other ailments. Brine shrimp lethality (cytotoxicity) assay and acute toxicity were also evaluated, which are considered a useful tool for preliminary assessment of toxicity in plant ext

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Efdi, Mai, Ridho Sahary Adha, and Adlis Santoni. "Profil Fitokimia dan Uji Toksisitas Daun Tumbuhan Aglaia Odorata dengan Metode Brine Shrimp Lethality Test." Jurnal Kimia Unand 11, no. 2 (2022): 1–4. http://dx.doi.org/10.25077/jku.11.2.1-4.2022.

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Toxicity and phytochemistry assay have been conducted on extracts and fractions of Aglaia odorata leaves using brine shrimp lethality test. Aglaia odorata is one of the plants that are found in Indonesia. To investigate Aglaia odorata leaves potential as anticancer, air-dried and powdered leaves were extracted with n-hexane, ethyl acetat, and metanol by using maceration method. Extract of ethyl acetat showed the highest toxicity with LC50 value is 125.89 mg/L

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Rafe, Md Rajdoula, Monira Ahsan, Choudhury Mahmood Hasan, and Mohammad Mehedi Masud. "Chemical and Biological Studies of Leaf Extract of Dendrophthoe falcata Linn." Dhaka University Journal of Pharmaceutical Sciences 16, no. 2 (2018): 215–19. http://dx.doi.org/10.3329/dujps.v16i2.35259.

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Dendrophthoe falcata (Family Loranthaceae) is used extensively in rural area as a component of ethno-medicine for the treatment of various diseases. In this study, the crude extracts and the fractions obtained from D. falcata were investigated for potential chemical constituents and some biological activities. For medicinal properties the antioxidant, brine shrimp lethality and thrombolytic activities have been investigated. The structures of the isolated three compounds were solved by extensive analyses of their high resolution 1HNMR spectroscopic data. They were identified as Lupeol, 3-β-ace

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