Relevant bibliographies by topics / BRKI

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Academic literature on the topic 'BRKI'

Author: Grafiati
Published: 4 June 2021
Last updated: 17 February 2022

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Journal articles on the topic "BRKI"

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Nee, M. J., A. Osterwalder, D. M. Neumark, C. Kaposta, C. Cibrián Uhalte, T. Xie, A. Kaledin, J. M. Bowman, S. Carter, and K. R. Asmis. "Experimental and theoretical study of the infrared spectra of BrHI− and BrDI−." Journal of Chemical Physics 121, no. 15 (October 15, 2004): 7259–68. http://dx.doi.org/10.1063/1.1794671.

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Knaus, Petra, and Walter Sebald. "Cooperativity of Binding Epitopes and Receptor Chains in the BMP/TGFß Superfamily." Biological Chemistry 382, no. 8 (August 28, 2001): 1189–95. http://dx.doi.org/10.1515/bc.2001.149.

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Abstract Bone morphogenetic proteins (BMP) are dimeric factors initiating several distinct signaling cascades by binding to two types of transmembrane serine/threonine kinase receptors (BRI and BRII), and are thus regulating several steps in embryonal development and adult tissue homeostasis. BMP-2 contains two symmetrical pairs of juxtaposed epitopes: the wrist epitope with high affinity to BRI consists of residues from both BMP-2 monomers, while the knuckle epitope resembles the low affinity site for BRII and comprises residues from only one monomer. Here we generated heterodimeric BMP-2 muteins with one monomer mutant in either epitope I for BRI (eI) or epitope II for BRII (eII) and the second monomer wild type for receptor interactions (m). These muteins (B2eI/B2m and B2eII/B2m) were analyzed by biosensor analysis as well as by measuring their biological activity and compared to their homodimeric forms (either wild type or mutant). Depletion of only one epitope II results in the loss of biological activity as measured by alkaline phosphatase (ALP) activity and Smad induced reportergene assays. However, depletion of only one epitope I shows a reduction of ALP activity to about 25%, while the activation of the Smad pathway remained normal. Homomeric muteins are nonfunctional for both Smad and ALP activation. This suggests that two functional epitopes II have to be present on one BMP-2 molecule for receptor activation. Futhermore, both pathways (Smad and ALP) are triggered differently by distinct BMPreceptor complexes. Heteromeric BMP-2 mutants therefore allow a distinguishable manipulation of either pathway and thus represent important tools for the generation of specific BMP-2 antagonists or agonists.
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Hartung, Anke, Keren Bitton-Worms, Maya Mouler Rechtman, Valeska Wenzel, Jan H. Boergermann, Sylke Hassel, Yoav I. Henis, and Petra Knaus. "Different Routes of Bone Morphogenic Protein (BMP) Receptor Endocytosis Influence BMP Signaling." Molecular and Cellular Biology 26, no. 20 (August 21, 2006): 7791–805. http://dx.doi.org/10.1128/mcb.00022-06.

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ABSTRACT Endocytosis is important for a variety of functions in eukaryotic cells, including the regulation of signaling cascades via transmembrane receptors. The internalization of bone morphogenetic protein (BMP) receptor type I (BRI) and type II (BRII) and its relation to signaling were largely unexplored. Here, we demonstrate that both receptor types undergo constitutive endocytosis via clathrin-coated pits (CCPs) but that only BRII undergoes also caveola-like internalization. Using several complementary approaches, we could show that (i) BMP-2-mediated Smad1/5 phosphorylation occurs at the plasma membrane in nonraft regions, (ii) continuation of Smad signaling resulting in a transcriptional response requires endocytosis via the clathrin-mediated route, and (iii) BMP signaling leading to alkaline phosphatase induction initiates from receptors that fractionate into cholesterol-enriched, detergent-resistant membranes. Furthermore, we show that BRII interacts with Eps15R, a constitutive component of CCPs, and with caveolin-1, the marker protein of caveolae. Taken together, the localization of BMP receptors in distinct membrane domains is prerequisite to their taking different endocytosis routes with specific impacts on Smad-dependent and Smad-independent signaling cascades.
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Wulf, Stefan. "„Schlagt das Hitlerei zu Brei.“." Medizinhistorisches Journal 55, no. 1 (2020): 47. http://dx.doi.org/10.25162/mhj-2020-0002.

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El-Gendy, Osama Rashad. "FUZZY BRK-IDEAL IN BRK-ALGEBRA." JP Journal of Algebra, Number Theory and Applications 36, no. 3 (July 22, 2015): 231–40. http://dx.doi.org/10.17654/jpantajun2015_231_240.

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Bhuiyan, MKA, L. Nahar, MM Mahbub, R. Shultana, MAJ Mridha, MA Rahman, and M. Kamruzzaman. "Yield Response and Nitrogen use Efficiency of Boro Rice Varieties as Affected by Different Methods of USG and Prilled Urea Application." Bangladesh Agronomy Journal 19, no. 1 (October 9, 2016): 1–10. http://dx.doi.org/10.3329/baj.v19i1.29863.

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An experiment was conducted at the Bangladesh Rice Research Institute (BRRI), Gazipur during Boro season of 2013-14 and 2014-15 to find out the nitrogen use efficiency and yield of boro rice var. BRRI dhan28 and BRRI dhan29 under four N management practices such as application of prilled urea using prilled urea applicator, application of USG (2.7gm) using USG applicator, broadcasting of prilled urea following three splits and a control (without urea). The experimental design was RCBD replicated thrice. BRRI dhan29 with urea broadcasted plots produced higher grain yield (7.38t ha-1) followed by BRRI dhan29 with USG application (6.65 t ha-1). Hand broadcasting with urea fertilizer showed 15.38.5and 2.5, 9.89% higher grain yield than machine application of prilled urea and USG in BRRI dhan28 and BRRI dhan29, respectively. Grain yield showed a significant quadratic response to N fertilization and significant linear response with total dry matter production in both the varieties. Higher total N was uptake from urea broadcasted plots in BRRI dhan29 followed by urea broadcasted from BRRI dhan28. BRRI dhan29 with Prilled urea applicator and BRRI dhan29 with USG treatment uptake intermediate nitrogen. N uptake in grain and total N uptake had a significant linear and quadratic response to N treatment in BRRI dhan28 and BRRI dhan29. Nitrogen use efficiency was higher in BRRI dhan29 compared to BRRI dhan28. Economic analysis showed that rice var. BRRI dhan28 and BRRI dhan29 with urea broadcast had the highest gross return of Tk.145145.00 and Tk. 158310.00 ha-1, respectively. However, the maximum cost (Tk. 151131) was involved for BRRI dhan29 with urea broadcasting, while the minimum with no urea fertilizer application for both the varieties. The highest marginal rate of return (MRR) (Tk.1146) was recorded from BRRI dhan28 with USG application using BRRI applicator.Bangladesh Agron. J. 2016, 19(1): 1-10
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Rambow, Amy A., Rachel C. Fernandez, and Alison A. Weiss. "Characterization of BrkA Expression inBordetella bronchiseptica." Infection and Immunity 66, no. 8 (August 1, 1998): 3978–80. http://dx.doi.org/10.1128/iai.66.8.3978-3980.1998.

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ABSTRACT BrkA confers resistance to killing by complement inBordetella pertussis. Complement resistance inBordetella bronchiseptica was examined. Four B. bronchiseptica strains possessed the brkA gene; however, only three expressed the protein. Only the strain lacking BrkA was susceptible to complement. Introduction of the B. pertussis brkA gene restored BrkA expression to this strain but did not confer resistance. brkA was mutated in the strains that naturally expressed BrkA, and loss of BrkA did not confer sensitivity to complement. As a species, B. bronchiseptica is more resistant to complement than B. pertussis, and BrkA does not mediate resistance.
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Sultana, Tania, S. Shamsi, and MA Bashar. "Prevalence of Fungi With Seeds of Twenty Brri Released Rice Varieties and Seed Quality Analysis." Journal of the Asiatic Society of Bangladesh, Science 44, no. 1 (June 25, 2018): 79–89. http://dx.doi.org/10.3329/jasbs.v44i1.46548.

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A total of 20 rice varieties of BRRI dhan 56 to BRRI dhan 75 were collected from Bangladesh Rice Research Institute (BRRI) for seed quality analysis, detection and identification of fungi associated with seeds of selected rice varieties. Dry inspection indicated that the percentage of pure seeds ranged from 90 - 100. The highest percentage of pure seed was found in BRRI dhan 66 and BRRI dhan 70 (100) and lowest in BRRI dhan 68 (90). A total of 21 fungal species were isolated from the selected rice varieties following “Blotter and Tissue Planting” methods. They were Alternaria padwickii, A. tenuissima, Aspergillus flavus, A. fumigatus, A. niger, A. ochraceus, A. clavatus, A. terreus, Bipolaris sorokiniana, B. spicifera, Chaetomium globosum, Curvularia lunata, Drechslera oryzae, Fusarium sp.1, Fusarium sp. 2, Nigrospora sp., Penicillium sp., Pestalotiopsis guepinii, Rhizopus stolonifer, Syncephalastrum racemosum and Trichoderma viride. Among them Penicillium sp., Drechslera oryzae, Aspergillus ochraceus, A. flavus, A. fumigatus, A. niger and Fusarium sp.1 were predominant in most of the rice varieties. In Tissue Planting method Drechslera oryzae showed the highest mean per cent frequency (6.69) and lowest was in the Bipolaris sorokiniana (0.41). Maximum total fungal association was recorded in variety BRRI dhan 61 (156.79%) and minimum in BRRI dhan 66 (24.69%). In Blotter method Penicillium sp. showed the highest mean per cent frequency (7.56) and lowest was in Rhizopus stolonifer (1.71). Maximum total fungal association was recorded in BRRI dhan 63 (147.37%) and minimum in BRRI dhan 65 (19.21%). Germination percentage of seeds was highest in BRRI dhan 66 (88) followed by BRRI dhan 67 (82), BRRI dhan 74 (80) and lowest in BRRI dhan69 (24). The percentage of seedling mortality was highest in BRRI dhan 63 (42) and lowest in BRRI dhan 74 (8.0) followed by BRRI dhan 67 (10). Correlation coefficient and regression analysis indicated that prevalence of fungi has significant effect on seed germination and seedling mortality. The present research work suggests that out of 20 BRRI rice varieties, BRRI dhan 65, BRRI dhan 66, BRRI dhan 67 and BRRI dhan 74 showed better performances on the basis of percentage of pure seed, fungal association, seed germination and seedling mortality. Asiat. Soc. Bangladesh, Sci. 44(1): 79-89, June 2018
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Saha, Shukanta, Hasna Hena Begum, and Shamima Nasrin. "Effects of Drought Stress on Growth and Accumulation of Proline in Five Rice Varieties (Oryza Sativa L.)." Journal of the Asiatic Society of Bangladesh, Science 45, no. 2 (December 28, 2019): 241–47. http://dx.doi.org/10.3329/jasbs.v45i2.46597.

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A pot experiment was conducted to study the effect of drought stress on growth and accumulation of proline in five rice varieties namely BRRI dhan-30, BRRI dhan-32, BRRI dhan-34, BRRI dhan-38 and BRRI dhan-56 and to characterize them on the basis of their behavior of drought tolerance. Drought stress caused the decrease of growth like root length, shoot length, root fresh weight, shoot fresh weight, root dry weight, shoot dry weight, the ratio of root-shoot length. Among the rice varieties, BRRI dhan-56 showed the lowest decrease of growth of plant. BRRI dhan-56 showed the least decrease of water content in both root and shoot. On the other hand, the accumulation of proline was increased in five rice varieties under stress. BRRI dhan-56 showed the highest (3.7- folds) increase in the accumulation of proline in leaf under stress. This study suggests that BRRI dhan-56 may possess drought tolerance characteristics while BRRI dhan-30, BRRI dhan-32, BRRI dhan-34 and BRRI dhan-38 may be drought sensitive based on their growth and proline accumulation behavior. Asiat. Soc. Bangladesh, Sci. 45(2): 241-247, December 2019
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Barman, HN, ME Hoque, RK Roy, PL Biswas, MAI Khan, and MO Islam. "Mature Embryo-Based in vitro Regeneration of Indica Rice Cultivars for High Frequency Plantlets Production." Bangladesh Rice Journal 20, no. 2 (September 29, 2017): 81–87. http://dx.doi.org/10.3329/brj.v20i2.34132.

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The study was conducted at Biotechnology Division of Bangladesh Rice Research Institute (BRRI) to investigate the effects of plant growing medium and plant growth regulator (PGR) for the callus induction and high frequency plantlets regeneration of indica rice. Ten indica rice varieties viz. BR5, BR11, BRRI dhan28, BRRI dhan29, BRRI dhan33, BRRI dhan41, BRRI dhan47, BRRI dhan48, BRRI dhan49 and BRRI dhan50 were cultured on MS, N6 and LS media. The MS medium was found better for callus induction as compared to N6 and LS media. Among the tested varieties BRRI dhan48 induced the highest percent and best quality callus. Interaction effects of BRRI dhan48 to MS medium yielded 71.55% callus induction. The regeneration efficiency of BRRI dhan48 was tested on MS medium supplemented with different combination of NAA plus BAP and NAA plus kinetin. MS medium supplemented with 2.0 mg L-1 NAA and 2.0 mg L-1 Kn was found the best in respect of percent regenerated (76.67%) plantlet as well as for the growth of plantlets in vitro.Bangladesh Rice j. 2016, 20(2): 81-87
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Dissertations / Theses on the topic "BRKI"

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Blechová, Klára. "Úvěrové registry a jejich využití." Master's thesis, Vysoká škola ekonomická v Praze, 2017. http://www.nusl.cz/ntk/nusl-359454.

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The aim of the thesis Credit registers and their usage is to evaluate the impact of credit registers usage in banking sector. The first part of the thesis focuses on description of credit registers, their creation and functioning at the level of the European Union. The second part describes and compares credit registers in the Czech Republic. The last part analyses the influence of negative information obtained from credit registers on the approval process and the use of registers when offering credit products to clients. In this part the positive influence of the use of credit registers in the banking sector is proved. The method of description and descriptive analysis is used in the thesis.
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Lu, Ying. "Interaction du bio-brai avec le coke : effet du bio-brai sur la formulation d'anode." Doctoral thesis, Université Laval, 2020. http://hdl.handle.net/20.500.11794/67909.

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Les producteurs d'aluminium sont constamment confrontés à des défis concernant l'augmentation des coûts de production et notamment ceux liés au brai de goudron de houille. Le brai de goudron de houille est utilisé comme liant pour produire des anodes en carbone. Indépendamment des avantages techniques du brai de goudron de houille, il contient des hydrocarbures aromatiques polycycliques (HAP), connus pour être cancérigènes pour l'homme et nocifs pour l'environnement. De plus, l’augmentation phénoménale de la production d’aluminium des trente dernières années exerce une pression importante sur le marché du brai, causant une difficulté en l’approvisionnement de ce dernier. Pour surmonter ce défi, des sources de substitution au brai de goudron de houille capables de résoudre les problèmes de coût et de santé sans diminuer la qualité de l'anode sont donc d'un grand intérêt pour l’industrie. Le bio-brai produit à partir de bio-huile, pourrait être un bon candidat à cet égard. Cependant, les propriétés du bio-brai pourraient être significativement différentes de celles du brai de goudron de houille en fonction de ses origines et des conditions de son procédé. Cette étude se concentre sur la synthèse de bio-brai à partir de bio-huile dans différentes conditions de pyrolyse et la caractérisation de ses propriétés physiques et chimiques, dans le but de déterminer les conditions qui peuvent conduire à des propriétés appropriées pour la formulation d'anode. Nous avons d’abord synthétisé du bio-brai dans différentes conditions. Les bio-brais produits ont été soigneusement caractérisés afin de comprendre l’effet du procédé de fabrication sur leurs propriétés. Parmi les caractérisations typiques, on peut nommer l’analyse chimique et la détermination de la densité, du point de ramollissement, de la valeur de cokéfaction, de la teneur en insolubles de quinoléine (QI), de la teneur en HAP, de la masse moléculaire, de la viscosité, de la composition élémentaire, des structures chimiques ainsi que des mécanismes de réaction se produisant pendant le processus de pyrolyse. Ensuite, nous nous sommes concentrés sur la caractérisation de l'interaction du bio-brai avec du coke afin de comprendre son comportement et son rôle, en tant que lien, lors de la fabrication d’anode. Les informations sur la capacité de mouillage du bio-brai à la surface de la particule de coke sont d'un grand intérêt pour évaluer son utilisation éventuelle en tant que liant dans la formulation d’anode. iv Nous avons montré que la mouillabilité du bio-brai est fortement influencée par sa viscosité, sa tension superficielle, ses groupes chimiques fonctionnels de surface, sa quantité de QI et sa distribution de masse moléculaire. La bonne mouillabilité du bio-brai améliore la densification de l'anode et atténue ainsi l'effet négatif de sa faible valeur de cokéfaction sur la densité de l'anode cuite. Afin d'optimiser les propriétés du bio-brai, l'étude visant à ajuster la teneur en QI a également été effectuée afin d'améliorer ainsi sa valeur de cokéfaction en ajoutant différentes quantités d'additif (bio-char).
Aluminium producers are constantly facing challenges regarding the increase in production costs including those related to coal-tar-pitch (CTP). CTP, a fossil material with carbon footprint, is used as binder to produce carbon anodes. Regardless of the technical benefits of CTP, it contains polycyclic aromatic hydrocarbons (PAHs), known to be carcinogenic for humans and detrimental to the environment. Furthermore, the escalating production capacity of aluminium during the past 3 decades exerts a considerable pressure on the pitch supply chain. To overcome this challenge, alternative sources to CTP capable of addressing the health issues and zero carbon footprint without decreasing anode quality, are thus of great interest. Bio-pitch, produced from bio-oil, could be a good candidate in this regard. However, the properties of bio-pitch could be significantly different from those of CTP depending on its origins and process conditions. This study focuses on the synthesis of bio-pitches from bio-oil under different pyrolysis conditions and characterization of its physical and chemical properties, aiming at determining the conditions which may result in suitable properties for anode formulation. We first synthesized biopitch from bio-oil under different conditions. The resulting biopitches were deeply characterized in order to understand the effect of process parameters on their properties. Among these typical characterizations are determination of density, softening point, coking value, quinoline insoluble, PAH content, molecular weight, viscosity, elemental composition, chemical structures as well as the reaction mechanisms occurring during the pyrolysis process. Then we focused on characterisation of biopitch interaction with coke in order to assess its behaviour and its role, as a binder, in anode formulation. Information on the wetting capacity of bio-pitch on the surface of coke particle is also of great interest in assessing its possible use as a renewable and environmental-friendly binder. It was shown that the wettability of bio-pitch is greatly influenced by its viscosity, surface tension, surface chemical functional groups, amount of quinoline insoluble, and molecular weight distribution. The good wettability of bio-pitch enhances the anode densification, thus mitigates the negative effect of its low coking value on the baked anode density. In order to improve the bio-pitch properties, the investigation to increase the QI content thereby to vi improve its coking value by adding different amounts of solid bio-char as an additive were also studied
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Sanseigne, Eric. "Mécanismes de formation de porosité au cours du traitement thermique d'un matériau coke-brai filé : relation avec l'évolution physico-chimique du brai." Mulhouse, 1993. http://www.theses.fr/1993MULH0294.

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La formation de porosité dans un produit coke - brai filé survient principalement durant le traitement thermique de cuisson, entre l'ambiante et 500°C. Les phénomènes physico-chimiques complexes qui se produisent durant la carbonisation du brai, comme le départ de matières volatiles, les réactions chimiques de polycondensation et les déformations du liant dans le matériau, ont une influence notoire sur la texture poreuse du produit fini. Nous avons montré, par une méthode d'analyse d'images, que dans les conditions expérimentales utilisées (vitesse de chauffe inférieure à 2 K/min), les composés de faible masse moléculaire diffusent dans le brai liquide sans qu'il y ait formation de bulles. L'étude par AED des paramètres de la transition vitreuse et de la relaxation enthalpique rend compte des modifications physico-chimiques du brai au cours du traitement thermique et de ses évolutions avec les conditions opératoires. De même, elle met en évidence l'existence d'une interaction coke - brai liée à l'abaissement de la mobilité des molécules de masse moléculaire élevée dans le brai en contact avec le coke. L'analyse d'images permet aussi de quantifier l'évolution de la porosité, de la taille et de la forme des pores dans le produit filé au cours du traitement thermique ainsi que leurs dépendances avec les conditions opératoires. La corrélation de ces résultats nous a permis de déterminer les mécanismes de formation de porosité mis en jeu durant le traitement thermique de cuisson. Les paramètres d'élaboration les plus influents ont ainsi pu être discernés
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Nutz, Michel. "Carbonisation et graphitation de mélanges brai de houille-graphite pulvérulent." Nancy 1, 1995. http://www.theses.fr/1995NAN10248.

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Ce travail, qui s'inscrit dans le cadre de recherches à finalités appliquées, vise à mieux comprendre les phénomènes physico-chimiques qui contrôlent et favorisent le développement des textures anisotropes lors de l'élaboration des graphites artificiels. Pour cela, nous avons étudié les interactions de brais de houille avec différents types de graphite pulvérulent en analysant les matériaux obtenus au cours du traitement thermique. Les mélanges de départ brai-graphite ont été caractérisés par leurs propriétés rhéologiques. L’addition de graphite dans la matrice de brai conduit à une augmentation de la viscosité du milieu. Par ailleurs, l'analyse rhéologique met en évidence la fixation de fractions lourdes du brai à la surface des particules de graphite. L’effet de charge sur l'évolution thermique du brai entraine une modification importante du mécanisme de développement de la mésophase. L’orientation préférentielle des espèces les plus lourdes du brai à la surface du graphite conduit à une démixtion de phases. Celle-ci se traduit notamment par l'apparition d'une phase anisotrope associée au graphite qui induit une préorientation structurale du matériau. L’analyse de l'aptitude à la graphitation des systèmes brai-graphite met en évidence un effet de mémoire du phénomène d'orientation induite qui se traduit par une graphitation a plus basse température en présence de particules de graphite. Cet effet est d'autant plus fort que l'anisotropie des particules de graphite est importante. Il est également lié au taux de charge, l'orientation à longue distance se manifestant par une teneur optimale de graphite dans le milieu
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Dumont, Mikaël. "Composites Carbone/Carbone 3D densifiés par imprégnation/carbonisation de brai mésophasique." Bordeaux 1, 2001. http://www.theses.fr/2001BOR12344.

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L'utilisation des composites C/C reste encore très limitée; des efforts importants sont menés pour développer de nouveaux procédés de fabrication moins coûteux. L'objectif de cette recherche était d'évaluer la potentialité d'une nouvelle génération de brai synthétique 100% anisotrope à taux de coke élevé comme précurseur de matrice de carbone. A partir des caractérisations du brai et de son comportement lors de la pyrolyse, un procédé de densification à basse pression a été développé. Les matériaux composites C/C ainsi réalisés ont été caractérisés au plan structural, microstructural, thermique, mécanique et en dilatation. Le comportement mécanique plus linéaire et moins endommageable comparé à celui des C/C obtenus par voie gazeuse peut être expliqué par la texture de la matrice ex-brai anisotrope et la présence de liaisons fortes fibre/matrice résultant de la réactivité du brai avec les fibres.
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Guajioty, Eric. "Etude du ressuage en recuisson d'électrodes de carbone imprégnées au brai." Grenoble INPG, 1989. http://www.theses.fr/1989INPG0074.

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La recuisson a 333#oc d'electrodes en carbones impregnees au brai de houille conduit a une importante perte d'impregnant (exsudat: 36%). Le moteur principal de l'ecoulement est constitue par les gaz formes en cours de recuisson dont l'origine est double: (i) thermodecomposition et (ii) reaction du brai avec les groupes oxygenes superficiels du substrat. Leur destruction par prechauffage des electrodes a 800#oc sous azote avant impregnation diminue d'un tiers le ressuage, ameliorant ainsi les caracteristiques de produits apres graphitation
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Hägebarth, Andrea. "Brk tyrosine kinase signaling in the gastrointestinal tract." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2005. http://dx.doi.org/10.18452/15379.

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Die Tyrosin Kinase Brk stellt den Prototypen nicht N-terminal myristoylierter, Nicht-Rezeptor Tyrosin Kinasen dar. Die Expression dieser Kinase ist auf epitheliale Gewebe beschränkt und wird während der Entwicklung differentiell reguliert. In normalen Geweben ist die Brk Expression auf nichtproliferierende, terminal differenzierte Zellen beschränkt. Um die regulatorische Funktion von Brk im murinen Darmepithel zu untersuchen, wurde das brk Gen in der Maus inaktiviert. Brk knockout Mäuse zeigten keine offensichtlichen Defekte in ihrer Entwicklung jedoch eine erweiterte Proliferationszone in den Krypten des Darmepithels und verlängerte Villi. Die Inaktivierung von Brk führte zu einer erhöhten Akkummulation von nukleärem (-catenin sowie einer Hochregulierung des (-catenin Zielgens c-myc in den Krypten der knockout Mäuse. Zusätzlich zeigten Brk knockout Mäuse eine Aktivierung des Akt-Signaltransduktionswegs in ihrem Darmepithel. Im Gegensatz zu Wildtyp Mäusen waren Brk knockout Mäuse resistent gegenüber (-Strahlung, was die Anhäufung onkogener Mutationen und damit die Entwicklung von Krebs fördert. Eine Induktion der Expression des Brk-Proteins im Darmepithel behandelter Wildtyp Mäuse wurde festgestellt. Weiterhin traten bei Brk knockout Mäusen chronische Entzündungen des Darmepithels sowie eine erhöhte Sensibilität gegenüber dem Reizmittel DSS auf. Im Gegensatz dazu, zeigten Wildtyp Mäuse eine mit der Literatur Übereinstimmende Reaktion zu DSS verbunden mit einer Induktion der Brk Expression im Darmepithel. Zusammenfassend kann gesagt werden, dass die Brk Tyrosin Kinase eine entscheidende Rolle in der Aufrechterhaltung der Homöstase und Integrität des Darmepithels spielt. Insbesondere scheint Brk als wichtiger Faktor zur Bestimmung der Sensitivität epithelialer Zellen zu genotoxischem Stress zu fungieren. Entgegen der bisher vermuteten onkogenen Funktion in epithelialen Tumoren scheint Brk im normalen Darmepithel "Tumor Suppressor" Ähnliche Funtionen innezuhaben.
The Breast tumor kinase Brk is a prototypical non-myristoylated, non-receptor tyrosine kinase. Brk expression is epithelial-specific and ,in normal tissues, restricted to cells exiting the cell cycle and undergoing terminal differentiation. To determine the biological role of Brk in the gastrointestinal tract, we disrupted mouse brk by homologous recombination. Loss of Brk in the mouse resulted in increased intestinal epithelial cell turnover and the appearance of longer small intestinal villi. Brk deficient mice displayed enhanced accumulation of nuclear (-catenin and upregulation of the (-catenin target gene c-myc in the crypt compartment of small and large intestine. In addition, Brk deficient mice exhibited increased Akt kinase activity. Even though, there was no corresponding difference in base-line apoptosis in untreated wild-type and knockout animals. However, subjected to (-irradiation, Brk deficient animals were significantly impaired in the apoptotic response. Wild-type mice, however, exhibited normal levels of apoptosis following (-irradiation accompanied by a rapid induction of Brk expression in crypt cells. Furthermore, chronic inflammation was observed in Brk deficient mice, and they showed increased susceptibility to a colon injury model utilizing DSS. Interestingly, wild-type mice exhibited a significant upregulation of nuclear Brk protein throughout the intestinal epithelium in response to DSS. These recent findings suggest that Brk plays a crucial role in the maintenance of intestinal tissue homeostasis and integrity. In addition, Brk may function to protect the intestinal epithelium against DNA-replication-induced errors and hence the development of cancer. Contrary to reported oncogenic properties of Brk in other epithelial tissues, Brk appears to have tumor suppressor-like functions in the mouse gastrointestinal epithelium.
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Lim, Shok Ping. "miR-181c modulates T cell function by regulating the expression of BRK1." Thesis, King's College London (University of London), 2017. https://kclpure.kcl.ac.uk/portal/en/theses/mir181c-modulates-t-cell-function-by-regulating-the-expression-of-brk1(fecd247a-3bb9-4fce-92c9-f1f5aeab2ffe).html.

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MicroRNAs are short endogenous non-coding RNAs that play pivotal roles in a diverse range of cellular processes. The miR-181 family is important in T cell development, proliferation and activation. In this study, we identified BRK1 as a novel target of miR-181c using a dual selection functional assay. Given the importance of miR-181 in T cell functions and the potential role of BRK1 in the WAVE2 complex as well as actin polymerisation in T cells, we therefore investigated the influence of the miR-181c-BRK1 axis in T cell functions. Stimulation of PBMC derived CD3+ T cells resulted in reduced expression of miR- 181c and upregulation of BRK1 protein expression, suggesting that the miR-181c- BRK1 axis might be important in T cell activation. To further assess the role of miR- 181c-BRK1 axis in T cell activation, we overexpressed miR-181c in Jurkat T cells and suppressed BRK1 in Jurkat and primary T cells. We showed that overexpression of miR-181c or suppression of BRK1 resulted in reduction in T cell activation and actin polymerisation coupled with impairment in lamellipodia generation and immunological synapse formation. Additionally, we found that BRK1 silencing led to reduced expressions of other proteins in the WAVE2 complex including WAVE2, ABI1 and SRA1, suggesting that impairment of actin polymerisation-dependent T cell functions were a result of the instability of the WAVE2 complex following BRK1 depletion. We also demonstrated a reciprocal relationship of miR-181c and BRK1 in BM derived CD3+ T cells from MDS patients associated with T-LGL leukaemia, suggesting the regulation of BRK1 protein expression by miR-181c in this group of MDS patients. Collectively, we demonstrated that BRK1 is a novel downstream target of miR-181c and highlighted the important role of miR-181c- BRK1 axis in T cell activation and actin polymerisation-mediated T cell functions.
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Malhotra, Divya. "brk1 and dcd1 Act Synergistically in Subsidiary Cell Formation in Zea mays." Thesis, University of North Texas, 2014. https://digital.library.unt.edu/ark:/67531/metadc799473/.

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Subsidiary mother cell (SMC) divisions during stomatal complex formation in Zea mays are asymmetric generating a small subsidiary cell (SC) and a larger epidermal cell. Mutants with a high number of abnormally shaped subsidiary cells include the brick1 (brk1) and discordia1 (dcd1) mutants. BRK1 is homologous to HSPC300, an ARP2/3 complex activator, and is involved in actin nucleation while DCD1 is a regulatory subunit of the PP2A phosphatase needed for microtubule generation (Frank and Smith, 2002; Wright et al. 2009). Possible causes of the abnormal SCs in brk1 mutants include a failure of the SMC nucleus to polarize in advance of mitosis, no actin patch, and transverse and/or no PPBs (Gallagher and Smith, 2000; Panteris et al 2006). The abnormal subsidiary mother cell division in dcd1 is due to correctly localized, but disorganized preprophase bands (PPBs; Wright et al. 2009). The observation that brk1 has defects in PPB formation and that the dcd1 phenotype is enhanced by the application of actin inhibitors led us to examine the dcd1; brk1 double mutant (Gallagher and Smith, 1999). We found that dcd1; brk1 double mutants demonstrate a higher percentage of aberrant SCs than the single mutants combined suggesting that these two mutations have a synergistic and additive effect on SC formation. Our observations and results are intriguing and the future step will be to quantitate the abnormal PPBs and phragmoplasts in the double and single mutants using immunolocalization of tubulin and actin as well as observations of live cells expressing tubulin-YFP.
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Smith, Justyn Glynn. "Essence, Revelation, and Physicalism." Thesis, Virginia Tech, 2021. http://hdl.handle.net/10919/103599.

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Revelation is (roughly) the thesis that the natures of phenomenal properties are revealed through experience. In this paper, I respond to Antonin Broi's charge that if both Revelation and the quality space view of phenomenal properties are true, then counterintuitive results that speak against the truth of Revelation obtain. I present a qualified theory of Revelation that not only prevents his arguments from succeeding but has independent plausibility as a solution to worries about the alleged epiphenomenalism of phenomenal properties.
Master of Arts
When you taste a Golden Delicious apple, drink Ethiopian coffee, feel dental pain, hear classical music or have many other conscious experiences of things, there's *something it's like* to be in those states. The taste of the apple and the coffee and the feel of dental pain are phenomenal properties - the "feels" of things in the broadest possible sense. Philosophers wonder what these things - "feels" - really are. Are they neurological features of your brain or a material features generally or are they something different? In a recent essay, Antonin Broi attacks the idea that they are something other than material or brain states. If Revelation - the idea that experiences reveal the essences of phenomenal properties - and some ideas about the general nature of phenomenal properties are both true, then strange results arise. I argue against his reasoning and I give a better way to understand Revelation.
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Books on the topic "BRKI"

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Vujanović, Vojislav. Kozmologija riječi: Poliptih o pjesniku Amiru Brki. Sarajevo: Zalihica, 2007.

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Lil︠i︡a Brik: Zhiznʹ. 2nd ed. Moskva: Zakharov, 2010.

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Lili͡a Brik: Zhiznʹ. Moskva: Zakharov, 2002.

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Arsenʹeva, Elena. Braki sovershai︠u︡tsi︠a︡ na nebesakh. Moskva: "ĖKSMO", 2003.

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Susokolov, Aleksandr Aleksandrovich. Mezhnatsional'nye braki v SSSR. Moskva: Mysl', 1987.

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Susokolov, A. A. Mezhnat͡s︡ionalʹnye braki v SSSR. Moskva: "Myslʹ", 1987.

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Gde zakl︠i︡ucha︠i︡uts︠i︡a braki?: Roman. Moskva: ĖKSMO, 2011.

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Susokolov, A. A. Mezhnatsional'nye braki v SSSR. Moskva: Mysl', 1987.

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Duda, Jerzy. Bruki w krajobrazie Krakowa. Kraków: Tow. Miłośników Histori i Zabytków Krakowa, 1998.

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Saṃṇāṅ, Mʺau. Rẏaṅ phkā trabaek brai. [Phnom Penh]: Karphsāy rapās Paṇṇalăy Suriyāraṅsi, 2005.

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Book chapters on the topic "BRKI"

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Singh Bahal, Ashminder. "BRI." In South Asia and China, 72–83. London: Routledge India, 2021. http://dx.doi.org/10.4324/9781003146223-8.

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Corre, Philippe Le. "China’s BRI." In US–China Foreign Relations, 86–96. Abingdon, Oxon; New York: Routledge, 2021. |: Routledge, 2020. http://dx.doi.org/10.4324/9781003056683-10.

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Hayat, Khizar, Xiao-Chu Liu, and Bing-Yuan Cao. "Bipolar Fuzzy BRK-ideals in BRK-algebras." In Advances in Intelligent Systems and Computing, 3–15. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-66514-6_1.

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Jacobsen, Trude. "Querulous queens, bellicose brai." In Women Warriors in Southeast Asia, 48–63. Abingdon, Oxon ; New York, NY : Routledge, 2020. | Series: Routledge studies in the modern history of Asia: Routledge, 2020. http://dx.doi.org/10.4324/9781315737829-3.

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Upadhyay, Ujjwal. "BRI and BBIN." In South Asia and China, 84–94. London: Routledge India, 2021. http://dx.doi.org/10.4324/9781003146223-9.

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Mehrbrodt, Tabea. "Viele Köche verderben den Brei." In Psychologie der Sprichwörter, 173–79. Berlin, Heidelberg: Springer Berlin Heidelberg, 2016. http://dx.doi.org/10.1007/978-3-662-50381-2_20.

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Götter, Christian, and Johannes Kaufmann. "Kein Märchen vom süßen Brei." In Sinngeschichten, 125–30. Köln: Böhlau Verlag, 2013. http://dx.doi.org/10.7788/boehlau.9783412216245.125.

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Jain, M., and A. Gupta. "1018 Diamagnetic susceptibility of BrLi." In Diamagnetic Susceptibility and Anisotropy of Inorganic and Organometallic Compounds, 1068. Berlin, Heidelberg: Springer Berlin Heidelberg, 2007. http://dx.doi.org/10.1007/978-3-540-44694-1_1019.

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Tappeser, Beatrix, Alexandra Baier, Birgit Dette, and Hanne Tügel. "Viele Köche verwässern den Brei." In Die_blaue_Paprika, 102–14. Basel: Birkhäuser Basel, 1999. http://dx.doi.org/10.1007/978-3-0348-7828-9_7.

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Snyder, Francis. "The BRI Kaleidoscope: European Legal Pluralism and BRI Soft Law." In The European Union and China's Belt and Road, 42–59. London: Routledge, 2021. http://dx.doi.org/10.4324/9780367853235-4-6.

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Conference papers on the topic "BRKI"

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"Bale Sampling Tools Used in OSU’s BRDI Project." In 2014 ASABE Annual International Meeting. American Society of Agricultural and Biological Engineers, 2014. http://dx.doi.org/10.13031/aim.20141913549.

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List, Michael G., Steven E. Gorrell, and Mark G. Turner. "Investigation of Loss Generation in an Embedded Transonic Fan Stage at Several Gaps Using High Fidelity, Time-Accurate CFD." In ASME Turbo Expo 2008: Power for Land, Sea, and Air. ASMEDC, 2008. http://dx.doi.org/10.1115/gt2008-51220.

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The Blade-Row Interaction (BRI) rig at the Air Force Research Laboratory (AFRL), Compressor Aero Research Laboratory (CARL), has been simulated at three axial gaps between the highly loaded upstream stator row and the downstream transonic rotor using TURBO. Previous work with the Stage Matching Investigation (SMI) demonstrated a strong dependence of mass flow rate, efficiency, and pressure ratio on the axial spacing between an upstream wake generator and the downstream rotor through the variation of the axial gap. Several loss producing mechanisms were discovered and related to the spacings, referred to as close, mid, and far. In the SMI work, far spacing had the best performance. The BRI experiments were a continuation of the SMI work with the wake generator replaced by a swirler row to turn the flow and a deswirler row to create a wake by diffusion. Results of the BRI experiments showed a performance degradation between mid and far spacing which was not observed in SMI. This trend is seen in the numerical work as well, and the time-averaged data shows that the majority of this performance change occurred in the rotor. An unsteady separation bubble periodically forms and collapses as shocks reflect through the stator passage, creating additional aerodynamic blockage. The shed vortices induced by the unsteady loading and unloading of the stator trailing edge are chopped, with a frequency related to the spacing, by the rotor leading edge and ingested by the rotor. Once ingested the vortices interact in varying degrees with the rotor boundary layer. A treatment of the loss production in the BRI rig is given based on the time-accurate and time-averaged, high-fidelity TURBO results.
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Woods-Kazungu, Harold, Sabina Asensio-Cuesta, and Juan Miguel García-Gómez. "New technologies applied as alternative approaches in averting depression." In Congress on Innovation in Information and Communication Technologies 2017. Universitat Politècnica de València (Spain), 2017. http://dx.doi.org/10.46844/bri.17.00001.1.

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Woods-Kazungu, Harold, Sabina Asensio-Cuesta, and Juan Miguel García-Gómez. "Structure and Evaluation of a Social Networking Healthcare Platform: The Case of Huzuni." In Congress on Innovation in Information and Communication Technologies 2018. Universitat Politècnica de València (Spain), 2018. http://dx.doi.org/10.46844/bri.18.00002.2.

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KAMRUL, N., M. KAMRUZZAMAN, and M. N. ISLAM. "EFFECT OF DRYING CONDITION ON MILLING QUALITY AND GERMINATION OF BRRI 29." In The Proceedings of the 5th Asia-Pacific Drying Conference. World Scientific Publishing Company, 2007. http://dx.doi.org/10.1142/9789812771957_0079.

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Hennebry, E., E. Court, A. Bartlett, and S. Dennis. "88 COVID and the BRI: a hip fracture story." In ESRA 2021 Virtual Congress, 8–9–10 September 2021. BMJ Publishing Group Ltd, 2021. http://dx.doi.org/10.1136/rapm-2021-esra.88.

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Hussain, H., and A. Harvey. "Abstract P3-07-05: Potential of breast tumour kinase (Brk) as a therapeutic target: Brk modulates drug responses in breast cancer cell lines." In Abstracts: 2017 San Antonio Breast Cancer Symposium; December 5-9, 2017; San Antonio, Texas. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.sabcs17-p3-07-05.

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Adem, K., and U. Orhan. "Imaging processing based quality control of transversal seams in Tetra Brik Aseptic cartons." In 2013 21st Signal Processing and Communications Applications Conference (SIU). IEEE, 2013. http://dx.doi.org/10.1109/siu.2013.6531591.

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Wahyuni, Mira, Eeng Ahman, and Suci Aprilliani Utami. "Determinant Micro Financing Repayment In Bank Bri Syariah Kcp Cimahi." In 1st International Conference on Islamic Ecnomics, Business and Philanthropy. SCITEPRESS - Science and Technology Publications, 2017. http://dx.doi.org/10.5220/0007089507680772.

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Djurović, S., N. Konjević, and M. S. Dimitrijević. "Plasma broadening of BrI and II lines from (1D2)np levels." In Spectral line shapes. AIP, 1990. http://dx.doi.org/10.1063/1.39873.

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Reports on the topic "BRKI"

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Pritikin, M., M. Richardson, T. Eckert, M. Behringer, and K. Watsen. Bootstrapping Remote Secure Key Infrastructure (BRSKI). RFC Editor, May 2021. http://dx.doi.org/10.17487/rfc8995.

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Tyner, Angela L. Breast Tumor Kinase (BRK) Signaling in Breast Cancer. Fort Belvoir, VA: Defense Technical Information Center, June 2002. http://dx.doi.org/10.21236/ada407665.

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Tyner, Angela L. Breast Tumor Kinase (BRK) Signaling in Breast Cancer. Fort Belvoir, VA: Defense Technical Information Center, June 2004. http://dx.doi.org/10.21236/ada428503.

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Singh, Monika, and Mudumbai Ranganathan. Formal Verification of Bootstrapping Remote Secure Key Infrastructures (BRSKI) Protocol Using AVISPA. National Institute of Standards and Technology, October 2020. http://dx.doi.org/10.6028/nist.tn.2123.

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Faivre, Emily. Regulation of Cell Fate by Breast Tumor Kinase (BRK). Fort Belvoir, VA: Defense Technical Information Center, June 2004. http://dx.doi.org/10.21236/ada427190.

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McIntosh, A. C., and Jr. Barnes & Reinecke, Inc. (BRI) Palletized Loading System (PLS) Flatrack Transportability Testing. Fort Belvoir, VA: Defense Technical Information Center, November 1997. http://dx.doi.org/10.21236/ada353941.

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Storm, Maarten, and Frans Rip. Derde externe audit van de Basisregistratie Kadaster : Rapportage en verklaring over de kwaliteit van de BRK. Wageningen: Wageningen Environmental Research, 2019. http://dx.doi.org/10.18174/474504.

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Lofgren, Kristopher. Investigation of the Role of Breast Tumor Kinase (Brk) in ERK5 and p38-Mediated Breast Cancer Cell. Fort Belvoir, VA: Defense Technical Information Center, October 2007. http://dx.doi.org/10.21236/ada484006.

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Tyner, Angela L. A Small Scale Proteomics Approach for Identifying Proteins Regulated by the Breast Tumor Kinase BRK Signal Transduction Pathway. Fort Belvoir, VA: Defense Technical Information Center, June 2002. http://dx.doi.org/10.21236/ada406106.

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Nimnual, Anjaruwee S. Characterization of the Role of Breast Tumor Kinase (Brk) in Breast Cancer Cells Non-Responsive to EGFR-Targeted Agents. Fort Belvoir, VA: Defense Technical Information Center, July 2008. http://dx.doi.org/10.21236/ada488821.

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