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Dissertations / Theses on the topic 'Brl2'

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Published: 4 June 2021

Last updated: 2 February 2022

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1

Rajput, Abdul Mateen. "Histone modifications after DNA damage affect survival in Schizosaccharomyces pombe." Thesis, Södertörns högskola, Institutionen för livsvetenskaper, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-6886.

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S. cerevisiae Ada2 and Bre1 has a role in histone post-translational modifications. Deletion of these genes causes deficiency in acetylation (Ada2) or ubiquitination (Bre1) of histones. Further, mutants lacking these genes or homologous genes showed different phenotypes in human and S. cerevisiae while treated with DNA damaging agents 4-NQO and MMS. Bre1 deficient cells showed 4-NQO sensitivity in S. cerevisiae and resistance in human cells. Since it has been shown that S. pombe is more close to mammals in chromatin regulation we wanted to examine S. pombe response against MMS and 4-NQO. By ho

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Pedreira, Vanda do Amaral V. "Espectroscopia Raman em compostos KBr-Br2, KI-Br2 e do HOPG-Br2." [s.n.], 1996. http://repositorio.unicamp.br/jspui/handle/REPOSIP/277833.

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Orientador: Gilberto M. Gualberto<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Fisica Gleb Wataghin<br>Made available in DSpace on 2018-07-21T21:13:10Z (GMT). No. of bitstreams: 1 Pedreira_VandadoAmaralV_M.pdf: 844584 bytes, checksum: 2a2b2be7ecb54390cbe9dab4102cf709 (MD5) Previous issue date: 1996<br>Resumo: Os cristais iônicos KBr e KI não apresentam atividade Raman. Espectros Raman destes cristais, após imersão em bromo líquido, exibiram linhas com freqüências identificadas como sendo devida aos compostos KBr3 e IBr, ao Br2 e às formas alotrópicas 79Br -79Br

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3

Martin, Lucas. "Regulierte Intramembranproteolyse des Bri2-Proteins." Diss., lmu, 2010. http://nbn-resolving.de/urn:nbn:de:bvb:19-116375.

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4

Hamm, Michael. "Le rôle du facteur de transcription BRN2 dans la mélanomagenèse." Thesis, Paris Sciences et Lettres (ComUE), 2018. http://www.theses.fr/2018PSLET017.

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La mélanomagenèse est un processus comportant de multiples étapes incluant l’initiation et la progression. Certaines protéines sont fonctionnellement importantes pour l’induction de la mélanomagenèse in vivo. Ces protéines possèdent soit des mutations oncogéniques (ex. BrafV600E, NrasQ61K/R, β-cateninsta/Dex3), soit leur présence/activité est perdue (Pten ou p16INK4A). BRN2 (POU3F2) est un facteur de transcription de la famille des protéines POU, impliqué dans la signalisation dans le mélanome, régulé par Braf, β-catenin et PI3K/Pten néanmoins les fonctions exactes de Brn2 dans la mélanomagenè

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Agkatsev, Sarina. "Regulation of MITF and Brn2 in melanoma." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:58354c05-55b7-46ef-8903-df3703fd04be.

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Melanoma is the most aggressive skin cancer with high recurrence and low survival rate. In addition to genetic mechanisms, resistance also arises from phenotypic heterogeneity in which a proportion of cells, the so-called melanoma stem or initiating cells, survive therapy. Due to a lack of reliable markers, however, there is still debate about the existence of these cells in melanoma. Consistent with phenotypic heterogeneity, previous observations in our laboratory have demonstrated that cells in melanoma can reversibly segregate in vivo into different subpopulations with different properties,

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Martins, Filipa de Sá. "Functional characterization of novel BRI2 and BRI3 complexes." Doctoral thesis, Universidade de Aveiro, 2017. http://hdl.handle.net/10773/21229.

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Doutoramento em Biomedicina<br>A BRI2 e a BRI3 são proteínas transmembranares de tipo II cujas funções fisiológicas ainda não se encontram bem caracterizadas. Duas mutações autossómicas dominantes no gene BRI2 estão na origem de duas formas de demência rara: Demência Familiar Britânica e Demência Familiar Dinamarquesa. Estas partilham características clinicas e neuropatológicas com a doença de Alzheimer, nomeadamente deposição de proteínas anormais no cérebro. Apesar de nunca ter sido associada a qualquer doença, a BRI3 está enriquecida no sistema nervoso central o que sugere que possa

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Lashley, Tammaryn. "BRI2 gene-related dementias : a morphological and biochemical study." Thesis, University College London (University of London), 2006. http://discovery.ucl.ac.uk/1444924/.

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Aspects of the neurodegenerative mechanism in AD remain unknown therefore studies on alternative models of cerebral amyloidosis, such as familial British dementia (FBD) and familial Danish dementia (FDD) may contribute to a better understanding of the neurodegenerative process. FBD and FDD are neurodegenerative disorders caused by mutations in the BRI2 gene. Both mutations cause elongation of the precursor proteins, the furin-like cleavage of which results in the formation of amyloidogenic peptides, ABri in FBD and ADan in FDD. Extensive morphological examinations of FBD and FDD were undertake

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Herbert, Katharine. "The role of the transcription factor BRN2 in melanoma." Thesis, University of Oxford, 2018. http://ora.ox.ac.uk/objects/uuid:7d77a057-d8a0-4a10-a3a1-28e5abd7c005.

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Expression of the POU-domain transcription factor BRN2 is crucial for the developing brain and drives proliferation and invasiveness in cancers of neural crest origin including melanoma. However, our understanding of BRN2 function and how its behaviour is modulated remains incomplete. We therefore aimed to investigate how protein:protein interaction and post-translational modification might influence the activity of BRN2 and how this impacts on melanoma cell phenotype. We show that, surprisingly, BRN2 binds DNA-damage response proteins rather than transcriptional co-factors and that following

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9

Hahn, Daniela. "Brr2 RNA helicase and its protein and RNA interactions." Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/5775.

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The dynamic rearrangements of RNA and protein complexes and the fidelity of pre-mRNA splicing are governed by DExD/H-box ATPases. One of the spliceosomal ATPases, Brr2, is believed to facilitate conformational rearrangements during spliceosome activation and disassembly. It features an unusual architecture, with two consecutive helicase-cassettes, each comprising a helicase and a Sec63 domain. Only the N-terminal cassette exhibits catalytic activity. By contrast, the C-terminal half of Brr2 engages in protein interactions. Amongst interacting proteins are the Prp2 and Prp16 helicases. The work

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Yajjou, Halima. "Études moléculaires et structurales - d’un nouveau mode de dimérisation des intégrases rétrovirales pour développer des modulateurs d’oligomérisation ET - de l’intégrase porcine de PERV-A/C en complexe avec son cofacteur cellulaire humain Brd2 dans un contexte de xénotransplantatio." Thesis, Lyon, 2017. http://www.theses.fr/2017LYSE1035/document.

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L'intégrase (IN) est une enzyme essentielle du cycle réplicatif des rétrovirus, qui catalyse l'intégration de l'ADN viral rétrotranscrit dans le génome de la cellule cible. Des données structurales, précédemment obtenues par notre équipe, ont conduit à la conception rationnelle de molécules susceptibles de bloquer l'IN sous une forme oligomérique inactive. Des tests d'intégration concertée in vitro ont permis d'étudier leur effet sur l'activité enzymatique de l'IN.Le porc est porteur d'un Gammaretrovirus endogène appelé Porcine Endogenous RetroVirus (PERV), susceptible d'être transmis à l'homm

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Crawford, Rebecca. "The role of BRF1 and BRF2 in the immune response." Thesis, Imperial College London, 2008. http://hdl.handle.net/10044/1/4433.

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Tristetraprolin (TTP), butyrate response factor 1 (BRF1) and butyrate response factor 2 (BRF2) are members of a family of zinc finger containing ARE binding proteins known as the Zfp36 family. They all possess a conserved tandem zinc finger domain, which facilitates their binding to mRNAs that contain adenosine/uridine rich elements (ARE) in their 3' untranslated region (3'UTR). Binding to the target mRNA results in its destabilisation. Several mRNAs containing an ARE in their 3'UTR are stabilised by the mitogen activated protein kinase (MAPK) p38 pathway. Both the expression and the mRNA dest

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Chahpazoff, Margaux. "Étude moléculaire et structurale de l’intégrase du virus porcin PERV et de son partenaire cellulaire humain Brd2, dans le cadre de la prévention de xénozoonoses rétrovirales." Thesis, Lyon, 2020. http://www.theses.fr/2020LYSE1003.

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L’utilisation d’organes porcins pourrait pallier le déficit d’organes humains pour les patients en attente de greffe. Le développement de cette technique est cependant limité par la présence d’un rétrovirus endogène actif dans le génome des cellules porcines. L’intégrase (IN) du rétrovirus recombinant endogène porcin PERV-A/C catalyse une étape clé du cycle rétroviral et constitue une cible thérapeutique de choix. Cette IN utilise un cofacteur cellulaire, la protéine Brd2, qui permet le ciblage de sites d’intégration spécifiques et une infection productive. La première partie du manuscrit port

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13

Hemmingsson, Lovisa. "Bri2 BRICHOS domain : Eukaryotic expression and importance of strictly conserved cysteine residues." Thesis, Linköpings universitet, Institutionen för fysik, kemi och biologi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-138401.

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Alzheimer’s disease (AD), the most common form of dementia is associated with fibril formation of amyloid-ß peptides (Aß). Aß, proteolytically derived from Aß precursor protein (AßPP), is the major component of amyloid plaques in AD brains. Familial British and Danish dementias (FBD and FDD) share pathological and clinical characteristics with AD, and the underlying mechanisms are associated with amyloid formation of mutant peptides released from the Bri2 protein. Bri2 interacts with AßPP and its BRICHOS domain has been shown to delay Aß40 and Aß42 fibril formation and toxicity in vitro and in

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14

Urban, Sylvia. "Brn2 et Zic1 spécifient l'identité neuronale des cellules souches embryonnaires murines lors de la différenciation induite par l'acide rétinoïque." Thesis, Strasbourg, 2014. http://www.theses.fr/2014STRAJ115/document.

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Les cellules souches embryonnaires (ES) murines peuvent être différenciées in vitro en une population homogène de neurones glutamatergiques semblables aux neurones présents dans le cortex in vivo, suite à un traitement par l’acide rétinoïque (AR). Bien que le rôle de l’AR soit bien étudié, les facteurs qui spécifient le destin neuronal ne sont pas connus. Nous montrons ici que Pou3f2 (Brn2) est un facteur essentiel à la différenciation neuronale des cellules ES in vitro. L’utilisation de l’approche de différenciation in vitro associée à des techniques de génomique à haut débit (RNA-seq, ChIP-s

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Murphy, Tami J. "Phenotypic analysis of transcriptional co-activator, brd2, gene knockdowns in zebrafish (Danio rerio) embryos." Click here for download, 2007. http://proquest.umi.com/pqdweb?did=1288659571&sid=1&Fmt=2&clientId=3260&RQT=309&VName=PQD.

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Burns, Robert. "Comparison of skeletal morphology of Brd2 heterozygous mice against wild type C57/B6J mice." Thesis, Boston University, 2012. https://hdl.handle.net/2144/12302.

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Thesis (M.A.)--Boston University PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.<br>Objectives: The purpose of the study was to characterize age related bone lose in male and female mice lacking one functional copy of the Brd2 gene. These mice will develop age related obesity but will not devel

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Semer, Maryssa. "Le facteur de réparation XPC est un cofacteur de l'ARN polymérase II régulant les modifications post-traductionnelles des histones lors de la transcription." Thesis, Strasbourg, 2018. http://www.theses.fr/2018STRAJ040/document.

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La voie de réparation NER implique une cascade de complexes protéiques dont le senseur des dommages de l’ADN (XPC/HR23B). Des mutations dans les gènes de la NER (TTD-A, XPA-G, XPV, CSA et CSB), sont associées à des maladies génétiques humaines dont le Xeroderma Pigmentosum (XP), la Trichothiodystrophie (TTD) et le syndrome de Cockayne (CS). L’ensemble des symptômes des patients ne peut être expliqué seulement par un défaut de la réparation de l’ADN. Or depuis quelques années, il a été prouvé que les facteurs de la NER sont aussi impliqués lors de la transcription. Dans le cadre de ma thèse, je

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Iveson, Christian. "Um modelo de volatilidade estocástica para opções de câmbio sobre o par eur/brl a partir de seus componentes mais líquidos usd/brl e eur/usd." reponame:Repositório Institucional do FGV, 2010. http://hdl.handle.net/10438/4303.

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Made available in DSpace on 2010-04-20T21:00:34Z (GMT). No. of bitstreams: 4 Christian Iveson.pdf.jpg: 2437 bytes, checksum: 5b4d46426416179606b69db641261db0 (MD5) Christian Iveson.pdf.txt: 57597 bytes, checksum: 1ca02c93753aa2ac6275ae7717783a78 (MD5) license.txt: 4712 bytes, checksum: 4dea6f7333914d9740702a2deb2db217 (MD5) Christian Iveson.pdf: 332695 bytes, checksum: e2abb94a3f44817a92530580acdc24dc (MD5) Previous issue date: 2010-01-20T00:00:00Z<br>Este trabalho tem por objetivo a precificação de opções de câmbio de EUR/BRL em função de seus componentes mais líquidos USD/BRL e EUR/US

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Melville, Heather. "Spatiotemporal analysis of apoptosis patterns in the developing brain of the Brd2-knockdown zebrafish embryo." Click here for download, 2009. http://proquest.umi.com/pqdweb?did=1851609811&sid=1&Fmt=2&clientId=3260&RQT=309&VName=PQD.

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Bade, Sangeeta. "Role of Bre2 and Sdc1 in the regulation of histone lysine methylation by Set1 Complex." OpenSIUC, 2011. https://opensiuc.lib.siu.edu/theses/634.

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The Set1 complex, often called COMPASS (Complex associated with Set1 subunit), is a multi-protein complex containing the trithorax-related protein, Set1, which methylates histone H3 lysine-4 (H3K4) and additional substrates. The catalytic SET domain of Set1 requires a host of associated subunits to catalyze the transfer of methyl groups from S-adenosylmethionine to lysine residues of target substrates. Bre2 and Sdc1 are two subunits that promote H3K4 tri-methylation, a hallmark modification found at promoters of activatated RNA polymerase II genes. In collaboration with Sharon Dent's group,

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Lorenz, Susanne. "Molekulargenetische Identifizierung von Determinanten der photoparoxysmalen Reaktion." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2006. http://dx.doi.org/10.18452/15536.

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Die Photoparoxysmale Reaktion (PPR) oder Photosensitivität ist elektrophysiologisch durch eine synchronisierte Erregungssteigerung des visuellen Kortex infolge intermittierender Lichtreize gekennzeichnet. Familienstudien belegen, dass die PPR eine genetisch komplexe Disposition aufweist. Visuell induzierte Anfälle treten bei bis zu 10% der Kinder mit Epilepsien auf. Besonders häufig (bis zu 30%) ist die PPR mit den idiopathisch generalisierten Epilepsien (IGE) assoziiert. Die PPR repräsentiert somit einen geeigneten Endophänotyp, um die pathogenetische Komplexität der IGE zu reduzieren und auf

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Ibrahim, Heide Nadda. "Tracking coherences in a dissipative ocean analysing and controlling Br2/Ar matrix." Göttingen Cuvillier, 2008. http://d-nb.info/989862305/04.

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Drevon, Philippe Fernandes. "Comportamento do BRL-USD na vizinhança de vencimentos de derivativos de câmbio." reponame:Repositório Institucional do FGV, 2016. http://hdl.handle.net/10438/17273.

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Submitted by Philippe Fernandes Drevon (lipefedr@hotmail.com) on 2016-10-07T20:50:27Z No. of bitstreams: 1 Dissertação de Mestrado(trabalhofinal).pdf: 1373981 bytes, checksum: 270f1df4c650fbdb83fb69b9f43143e8 (MD5)<br>Approved for entry into archive by GILSON ROCHA MIRANDA (gilson.miranda@fgv.br) on 2016-10-11T15:48:29Z (GMT) No. of bitstreams: 1 Dissertação de Mestrado(trabalhofinal).pdf: 1373981 bytes, checksum: 270f1df4c650fbdb83fb69b9f43143e8 (MD5)<br>Approved for entry into archive by Maria Almeida (maria.socorro@fgv.br) on 2016-10-17T19:34:01Z (GMT) No. of bitstreams: 1 Dissertação d

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Tufféry, Christophe. "Des SIG pour quoi faire ? : le cas de BRL (gestion, études, partenariat)." Avignon, 1994. http://www.theses.fr/1994AVIG1004.

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Une analyse de l'expérience d'une dizaine d'années en cartographie numérique à BRL est proposée : celle-ci s'inscrit dans l'histoire de l'entreprise, dans l'évolution de ses métiers et dans la redéfinition de sa stratégie et de son positionnement commercial en région Languedoc Roussillon et à l'étranger. La demande explicite et implicite en information géographique est ensuite analysée pour définir les fonctionnalités d'un SIG à mettre en place à BRL. Celui-ci se décline par applications dont trois, considérées comme prioritaires, sont décrites et leurs résultats sont présentés en termes criti

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Flammiger, Anna. "Expression von Nestin und Osteopontin in Melanomzelllinien und die Rolle der Transkriptionsfaktoren BRN2, SOX9 und SOX10." Diss., lmu, 2009. http://nbn-resolving.de/urn:nbn:de:bvb:19-109457.

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Diviney, Patrick. "Investigation of spinal bone morphology during aging in genetically obese heterozygous BrD2 mice compared to C57/B6J mice." Thesis, Boston University, 2013. https://hdl.handle.net/2144/12089.

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Thesis (M.A.)--Boston University<br>Osteoporosis is a metabolic disease that affects individuals by causing bone quality to ultimately decrease, and therefore, makes these individuals more susceptible to fractures. Osteoporosis affects a large number of older individuals and causes high numbers of fractures that result in an increased morbidity. Osteoporosis, while considered a silent disease, presents a major health concern in our country as the number of elderly individuals dramatically increases. There are three primary factors that have an effect on bone loss: gender, age, and obesity with

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Hog, Michael [Verfasser], Ingo [Akademischer Betreuer] Krossing, and Sebastian [Akademischer Betreuer] Hasenstab-Riedel. "Liquid mixtures based on AlBr3: Synthesis, characterization and first applications in Al/Br2-batteries." Freiburg : Universität, 2017. http://d-nb.info/1142113302/34.

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Pestel, Valentin. "Détection de neutrinos auprès du réacteur BR2 : analyse des premières données de l'expérience SoLid." Thesis, Normandie, 2019. http://www.theses.fr/2019NORMC238.

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L'expérience SoLid (Search for Oscillations with a Lithium-6 detector) mesure le flux d'anti-neutrino à proximité d'un réacteur de recherche (BR2, SCK-CEN, Belgique). Le premier objectif est de sonder l'anomalie "réacteur" et de tester l'hypothèse de l'existence de neutrino(s) stérile(s) "léger(s)" (Delta m2~1eV2). En second lieu, la mesure du spectre en énergie des neutrinos induit par la fission de l'uranium 235 offrira de nouvelles contraintes. Le détecteur d'une masse de 1,6 tonne, segmenté en 12800 cubes de détection de 5x5x5 cm3, repose sur une nouvelle technologie basée sur l'utilisatio

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López, Martínez José Eduardo, and Uribe Bernardo Antonio Frontana. "Oxidación Electroquímica de la Pregnenolona a Progesterona empleando el Sistema Br2/Tempo como Oxidante." Tesis de Licenciatura, Medicina-Quimica, 2014. http://ri.uaemex.mx/handle/123456789/14923.

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Hejjas, Monika Helena [Verfasser]. "Rational coherent control applied to Br2 molecules and their solid Ar environment / Monika Helena Hejjas." Berlin : Freie Universität Berlin, 2012. http://d-nb.info/1027151655/34.

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Ali, Saima. "Regulation of the cell surface expression and the function of GABA¦BR1a by GABA¦BR2." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0027/MQ50433.pdf.

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Kuswandi, Kus. "Mechanism of uptake of the catecholic (7)-α-formamido cephalosporin BRL 41897A by Klebsiella pneumoniae". Thesis, Aston University, 1996. http://publications.aston.ac.uk/15336/.

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In this thesis mutants of K. pneumoniae resistant to BRL 41897A were isolated using TnphoA mutagenesis and used to study the mechanism of uptake of BRL 41897A by K. pneumoniae. The activity of BRL 41897A towards the parent strain (M10) was increased in iron depleted media, whereas no significant differences in the resistant (KSL) mutants were observed. Three mutants (KSL19, KSL38and KSL59) produced decreased amounts of certain iron-regulated outer membrane proteins. The uptake of 55Fe-BRL 41897A by M10 in iron-deficient medium was higher than in iron-rich medium. This result indicated the invo

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Postell, David Jonathan. "Laser Induced Fluorescence Spectroscopy of molecular bromine: Observations of Emission to High Vibrational Levels in the Ground (X) State." Wright State University / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=wright1186777955.

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Majumder, Bhakti. "The performance of agricultural institutions in disseminating new technologies : a case study of the modern rice variety BR32 in Bangladesh." Thesis, University of Aberdeen, 2003. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=188101.

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Despite substantial public expenditure from domestic and international sources on free-to-user agricultural extension services in Bangladesh, there is a lag between the availability and application of seed technologies. Besides the slow pace of diffusion of newly generated modern varieties (MVs), there exist wide gaps between potential and achieved yields at the farm level. This study aims to assess the performance of Bangladeshi research and extension (R&E) institutions in disseminating new rice MVs to end-users, and to identify factors affecting farm-level diffusion of the disseminated MVs

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Wandersleben, Traudy [Verfasser]. "Structural basis for dual regulation of spliceosomal helicase Brr2 by the Prp8 Jab1 domain and links to retinal disease / Traudy Wandersleben." Berlin : Freie Universität Berlin, 2013. http://d-nb.info/1043687734/34.

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Bovo, Vitor Juliano. "Volatility Triggered Range Forward (VTRF): an instrument for protection against volatility fluctuations in the BRL/USD pair." reponame:Repositório Institucional do FGV, 2011. http://hdl.handle.net/10438/8552.

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Mozaffari-Jovin, Sina [Verfasser], Reinhard [Akademischer Betreuer] Lührmann, Reinhard [Akademischer Betreuer] Jahn, and Ralf [Akademischer Betreuer] Ficner. "Mechanism of regulation of spliceosome activation by Brr2 and Prp8 and links to retinal disease / Sina Mozaffari-Jovin. Gutachter: Reinhard Jahn ; Ralf Ficner. Betreuer: Reinhard Lührmann." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2013. http://d-nb.info/1044870877/34.

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Vacher, Dominique. "La thrombolyse en phase aigüe d' infarctus du myocarde : étude multicentrique randomisée APSAC (Anysoilated Plasminogen Streptokinase, ou BRL 26921) versus Héparine." Clermont-Ferrand 1, 1987. http://www.theses.fr/1987CLF11052.

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65 malades âgés de moins de 70 ans, souffrant d' un primo-infarctus du myocarde de moins de 5 heures, ont été soumis à un essai thérapeutique randomisé APSAC intra-veineux (bolus de 30 UI) versus traitement conventionnel héparinique. 33 patients ont reçu de l' héparine, 32 du BRL 26921. Malgré une défibrination constante, aucune complication grave liée à l' usage de l' APSAC n' a été relevée. L' efficacité du traitement a été jugée sur le taux de perméabilité coronaire à J3, la fonction ventriculaire gauche en angiographie et en scintigraphie cavitaire et la taille de la nécrose en tomo-scinti

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Berlin, Irina. "Role of BRN2 transcription factor in proliferation and migration of the melanocyte lineage and implication of β-catenin and Dicer in the response of melanocytes to UV irradiation". Paris 5, 2011. http://www.theses.fr/2011PA05T046.

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Les mélanocytes protègent lʼorganisme contre les effets délétères des rayonnements UV, en synthétisant de la mélanine. Leur transformation maligne entraine le développement de mélanomes, cancers particulièrement agressifs et résistants aux traitements. De nombreuses protéines, telles que BRN2, β-caténine et Dicer, impliquées dans divers processus cellulaires, sont dérégulées dans le mélanome. Cette thèse est consacrée à lʼimportance du statut de phosphorylation de BRN2 pour la prolifération et la migration du lignage mélanocytaire et à lʼimplication de BRN2, β-caténine et Dicer dans la réponse

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Santos, Karine [Verfasser], Markus [Akademischer Betreuer] Wahl, Ralf [Akademischer Betreuer] Ficner, et al. "Structural and functional studies of the spliceosomal RNP remodeling enzyme Brr2 / Karine Santos. Gutachter: Markus Wahl ; Ralf Ficner ; Detlef Doenecke ; Marina Rodnina ; Kai Tittmann ; Dirk Fasshauer. Betreuer: Markus Wahl." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2013. http://d-nb.info/1044362049/34.

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Santos, Karine Verfasser], Markus [Akademischer Betreuer] Wahl, Ralf [Akademischer Betreuer] Ficner, et al. "Structural and functional studies of the spliceosomal RNP remodeling enzyme Brr2 / Karine Santos. Gutachter: Markus Wahl ; Ralf Ficner ; Detlef Doenecke ; Marina Rodnina ; Kai Tittmann ; Dirk Fasshauer. Betreuer: Markus Wahl." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2013. http://d-nb.info/1044362049/34.

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Erguig, Hassane. "Contribution à l'étude des spectres de réflexion et de piézoréflexion de l'iodure cuivreux cui et des halogenures mixtes de plomb Pb CL2x Br2(1-x)( 0." Metz, 1990. http://docnum.univ-lorraine.fr/public/UPV-M/Theses/1990/Erguig.Hassane.SMZ9024.pdf.

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Dans la première partie de ce mémoire, nous décrivons la réalisation d'un montage de réflexion et piézoréflexion. Il permet la mesure de la variation relative de la lumière réfléchie par un échantillon soumis à une pression alternative en fonction de l'énergie de la lumière incidente aux basses températures et dans le domaine du visible. Dans la seconde partie, nous étudions les spectres de piézoréflexion des monocristaux de cui au voisinage de l'exciton 1sz#1#2 à 95 k. Le vecteur d'onde de la lumière incidente est perpendiculaire au plan de clivage (11) et les pressions alternatives sont appl

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Al, Andary Elsy. "Étude comparative des processus intégratifs des rétrovirus aviaires et porcins." Phd thesis, Université Claude Bernard - Lyon I, 2011. http://tel.archives-ouvertes.fr/tel-00866109.

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Les rétrovirus sont des virus à ARN, enveloppés présents dans de nombreuses espèces animales de rente, chez les animaux de compagnie et chez l'homme. Une des particularités des rétrovirus concerne l'intégration du génome viral au sein du génome de la cellule infectée; cette intégration est réalisée par une enzyme virale, l'intégrase. Le projet de cette thèse vise à mieux comprendre le fonctionnement de cette enzyme notamment en identifiant des facteurs cellulaires interagissant avec celle-ci, facteurs qui pourraient être des agents favorisant le processus intégratif ou, au contraire, des agent

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Santos, Mari Aparecida dos. "Impactos econômicos do Novo Código Florestal, no Brasil, 2010 a 2030: uma análise integrada com base nos modelos GLOBIOM-Brasil e TERM-BR." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/11/11132/tde-01082018-105535/.

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O Novo Código Florestal brasileiro se tornou em 25 de maio de 2012 o principal conjunto normativo ambiental instituído pela Lei n° 12.651/2012, que regulamenta a exploração, conservação e recuperação da vegetação nativa em nível nacional. Contudo tal legislação enfrenta Ações Diretas de Inconstitucionalidade (ADIs), as quais apontam prejuízos ambientais por causa da flexibilidade das novas regras relacionadas às áreas de preservação permanente, à redução da reserva legal e também à anistia para àqueles enquadrados por degradação ambiental antes de 22 de julho de 2008. O objetivo desta pesquisa

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de, Lira Oliveira Jadson. "Estudo dos parâmetros reacionais para síntese de 6,6 -di-halo-2,2 -bipiridinas e 2,2 : 6 , 2 -tripiridinas com base em um sistema eletrocatalítico de [Ni(bpy)]Br2." Universidade Federal de Pernambuco, 2011. https://repositorio.ufpe.br/handle/123456789/8095.

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Made available in DSpace on 2014-06-12T22:57:03Z (GMT). No. of bitstreams: 2 arquivo4101_1.pdf: 1923131 bytes, checksum: 8ab5cabb6d72d62a3f99eea7dc9dc9cd (MD5) license.txt: 1748 bytes, checksum: 8a4605be74aa9ea9d79846c1fba20a33 (MD5) Previous issue date: 2011<br>Conselho Nacional de Desenvolvimento Científico e Tecnológico<br>Neste trabalho foram investigadas as reações de homoacoplamento envolvendo 2,6- di-halopiridinas e de heteroacoplamento entre 2-bromopiridinas e 2,6-dicloropiridina, catalisadas pelo complexo [Ni(bpy)]Br2. Os ensaios foram realizados em célula de compartimento único

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Luterman, Rodolfo Nunes. "Derivativos de volatilidade no mercado brasileiro de câmbio: viabilidade e impactos de sua utilização." reponame:Repositório Institucional do FGV, 2013. http://hdl.handle.net/10438/10581.

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Submitted by Rodolfo Nunes Luterman (rluterman@gmail.com) on 2013-03-04T23:00:25Z No. of bitstreams: 1 Dissertação - Rodolfo Luterman - MPFE - Final.PDF: 1375397 bytes, checksum: 34f856bb109f53df096fcee82bee8a89 (MD5)<br>Approved for entry into archive by Suzinei Teles Garcia Garcia (suzinei.garcia@fgv.br) on 2013-03-05T13:20:00Z (GMT) No. of bitstreams: 1 Dissertação - Rodolfo Luterman - MPFE - Final.PDF: 1375397 bytes, checksum: 34f856bb109f53df096fcee82bee8a89 (MD5)<br>Made available in DSpace on 2013-03-05T13:27:59Z (GMT). No. of bitstreams: 1 Dissertação - Rodolfo Luterman - MPFE - Fi

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Abyad, Emad. "Modeled Estimates of Solar Direct Normal Irradiance and Diffuse Horizontal Irradiance in Different Terrestrial Locations." Thesis, Université d'Ottawa / University of Ottawa, 2017. http://hdl.handle.net/10393/36499.

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The transformation of solar energy into electricity is starting to impact to overall worldwide energy production mix. Photovoltaic-generated electricity can play a significant role in minimizing the use of non-renewable energy sources. Sunlight consists of three main components: global horizontal irradiance (GHI), direct normal irradiance (DNI) and diffuse horizontal irradiance (DHI). Typically, these components are measured using specialized instruments in order to study solar radiation at any location. However, these measurements are not always available, especially in the case of the DNI an

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Eaton, Jennifer Lynn. "The Molecular Control of Zebrafish Isotocin Cell Development: A Potential Model for the Neurodevelopmental Causes of Autism and Prader-Willi Syndrome." [Kent, Ohio] : Kent State University, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=kent1152190826.

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Thesis (Ph.D.)--Kent State University, 2006.<br>Title from PDF t.p. (viewed Sept. 19, 2006). Advisor: Eric Glasgow. Keywords: oxytocin; isotocin; vasopressin; vasotocin; hypothalamo-neurohypophysial system; hypothalamus; development; autism; Prader-Willi Syndrome; single-minded; orthopedia; arylhydrocarbon nuclear translocator; Brn2; POU; zebrafish; behavior; paraventricular nucleus; supraoptic nucleus; preoptic nucleus; diencephalon; suprachiasmatic nucleus; thyroid transcription factor; sonic hedgehog; NK 2 transcription factor related; distal-less homeobox gene; homeobox; homeodomain; morph

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Watzka, Michael. "Writing Scenes and Telling Time: Post-War German Journal Literature, Between Diary and the News(papers)." Thesis, 2021. https://doi.org/10.7916/d8-64xq-br72.

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Located at the intersection of literary, journalistic, and socio-historical discourses, “Writing Scenes and Telling Time” looks at diaristic texts in post-war German literature through the lens of news reporting and mass media. Since the 1970s, diaristic texts in German emerged across genres in the works of canonical authors. These works are widely read as subjective texts and linked to their authors’ supposedly diaristic interest in introspection and self-expression. However, these texts’ orientation towards the outside world and their interest in the temporality and scene of writing does not

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Martin, Lucas [Verfasser]. "Regulierte Intramembranproteolyse des Bri2-Proteins / Lucas Martin." 2010. http://d-nb.info/1003987036/34.

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