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Relevant bibliographies by topics / Broadly neutralizing antibodies (bNAbs) / Dissertations / Theses

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Dissertations / Theses on the topic 'Broadly neutralizing antibodies (bNAbs)'

Author: Grafiati

Published: 27 July 2024

Last updated: 31 July 2025

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1

Nemoz, Benjamin. "Exploration longitudinale à haut débit et en cellule unique du répertoire d'anticorps neutralisants à large spectre chez un neutraliseur d'élite du VIH-1." Electronic Thesis or Diss., Université Grenoble Alpes, 2024. http://www.theses.fr/2024GRALV012.

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L'infection par le virus de l'immunodéficience humaine de type 1 (VIH-1) reste un problème majeur de santé publique à l'échelle mondiale, avec environ 37,7 millions de personnes vivant avec le virus et de nouvelles contaminations dépassant le million de cas par an. Des antirétroviraux efficaces permettent maintenant de traiter durablement les personnes infectées. Ces thérapies contribuent également à améliorer la prévention et à ralentir la progression de l'épidémie. Cependant, un vaccin reste nécessaire, en particulier pour contrôler l'épidémie dans les régions à faible revenu et les environn

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2

Derby, Nina Rafterman. "Designing immunogens to elicit broadly reactive neutralizing antibodies to the HIV envelope /." Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/9302.

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3

Penn-Nicholson, Adam Garth. "Characterization and evaluation of approaches to elicit Broadly Reactive Neutralizing Antibodies against HIV-1." Case Western Reserve University School of Graduate Studies / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=case1205433621.

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4

Suphaphiphat, Karunasinee. "Anti-viral immune response in the semen of cynomolgus macaques and inhibition of cell to cell transmission by broadly neutralizing antibodies in an SIV/SHIV model of infection SHIV162P3 transmission by semen 1 leukocytes is efficiently 2 inhibited by broadly neutralizing antibodies." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS599.

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La transmission sexuelle du VIH-1 se fait principalement via du sperme infecté contaminé, contenant à la fois des virions libres et des leucocytes infectés. Les facteurs présents dans le liquide séminal peuvent aussi moduler l’infectivité du sperme et la réponse immunitaire de l’hôte. Ainsi, le macaque infecté par le virus de l’immunodéficience simienne (VIS) sera utilisé comme modèle expérimental afin d’étudier l’infectivité des cellules séminales, les réponses immunitaires anti-virales et évaluer l’effet inhibiteur d’anticorps neutralisant à large spectre (bNAbs) sur la transmission du virus

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5

Corti, Davide. "Analysis of the human B cell memory repertoire against infectious pathogens and isolation of broadly neutralizing human monoclonal antibodies /." Bern : [s.n.], 2008. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.

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6

Yuan, Tingting, and 袁婷婷. "Identification of intermediate antibodies of broadly neutralizing HIV-1 human monoclonal antibody b12 and characterization of variable loops of HIV-1 envelop glycoprotein." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/196445.

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7

Gardner, Matthew Ryan. "Targeting the CD4- and Coreceptor-Binding Sites of the HIV-1 Envelope Glycoprotein." Thesis, Harvard University, 2014. http://dissertations.umi.com/gsas.harvard:11644.

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The HIV-1 envelope glycoprotein, Env, facilitates the translocation of the viral capsid across the cellular membrane. Env is a trimer of hetero-dimers composed of a gp120 subunit and gp41 transmembrane protein. The gp120 subunit binds the primary receptor, CD4, leading to conformational changes of Env that then promote binding to the coreceptor, principally CCR5 or CXCR4. As the sole protein on the surface of the virion, Env is under continuous pressure from the host's antibody response. Two classes of antibodies target the highly conserved receptor-binding sites of gp120: CD4-binding site

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8

Cheng, Yuxing. "Elicitation of antibody responses against the HIV-1 gp41 Membrane Proximal External Region (MPER)." Thesis, Harvard University, 2014. http://dissertations.umi.com/gsas.harvard:11427.

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An effective vaccine to protect against HIV-1/AIDS remains elusive due to the extensive mechanisms employed by the HIV-1 virus to evade immune attack. Highly potent broadly neutralizing antibodies isolated from chronically infected individuals, however, show that such relevant antibodies can be naturally produced, implying that their elicitation through vaccination is a realistic possibility. These broadly neutralizing antibodies target different regions on the trimeric spikes formed by three protomers of the envelope (Env) protein. Each Env protein is comprised of the gp120 surface subunit in

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9

Miles, Brodie, Shannon M. Miller, and Elizabeth Connick. "CD4 T Follicular Helper and Regulatory Cell Dynamics and Function in HIV Infection." FRONTIERS MEDIA SA, 2016. http://hdl.handle.net/10150/622733.

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T follicular helper cells (T-FH) are a specialized subset of CD4 T cells that reside in B cell follicles and promote B cell maturation into plasma cells and long-lived memory B cells. During chronic infection prior to the development of AIDS, HIV-1 (HIV) replication is largely concentrated in T-FH. Paradoxically, T-FH numbers are increased in early and midstages of disease, thereby promoting HIV replication and disease progression. Despite increased T-FH numbers, numerous defects in humoral immunity are detected in HIV-infected individuals, including dysregulation of B cell maturation, impaire

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10

Hashem, Anwar. "Targeting the Highly Conserved Sequences in Influenza A Virus." Thèse, Université d'Ottawa / University of Ottawa, 2013. http://hdl.handle.net/10393/24058.

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All challenges associated with influenza A viruses including antigenic variation in hemagglutinin (HA) and neuraminidase (NA), the evolving drug resistance and the drawbacks of current vaccines hinder our ability to control this constant threat. Furthermore, gene reassortment as well as the direct transmission of highly pathogenic avian viruses to humans can result in an occasional emergence of novel influenza strains with devastating pandemic potential. Therefore, it is crucial to investigate alternative approaches to better control these viruses and to develop new prophylactic and treatment

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11

Rousset, Claire. "Coévolution entre les glycoprotéines d'enveloppe du VIH et les anticorps neutralisants à large spectre ciblant la région du glycane N332." Thesis, Université Grenoble Alpes (ComUE), 2018. http://www.theses.fr/2018GREAV071/document.

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Le VIH est la cause de la pandémie de SIDA depuis les années 1980. Avec plus d’un million de nouvelles infections chaque année, un vaccin prophylactique est indispensable pour bloquer de façon définitive la propagation du virus. Parmi les stratégies vaccinales, l’induction d’anticorps neutralisants à large spectre est une des plus prometteuses, car ceux-ci pourraient protéger contre l’infection par la grande diversité génétique des souches de VIH circulantes dans le monde. A ce jour, aucun immunogène n’a permis l’induction de tels anticorps, mais ils ont été isolés à partir de personnes infect

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12

Madzorera, Vimbai Sharon. "Engineering HIV viral variants as immunogens to stimulate Broadly Neutralizing Antibodies." Thesis, 2018. https://hdl.handle.net/10539/25326.

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A dissertation submitted to the Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, in fulfilment of the requirements for the degree of Master of Science in Medicine Johannesburg, 2018.<br>Southern Africa is currently the most affected region of the world in terms of the HIV/AIDS pandemic and despite decades of research into this virus, a vaccine that is adequately effective is yet to be developed. However, it is widely believed that broadly neutralizing antibodies (bNAbs) are likely to be required for protection. Eliciting bNAbs by vaccination has been challeng

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13

Scheepers, Cathrine. "Host factors and broadly neutralizing antibodies in South African women infected with HIV-1 subtype C." Thesis, 2016. http://hdl.handle.net/10539/19680.

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A thesis submitted to the Faculty of Health Sciences, School of Pathology, University of the Witwatersrand in fulfilment of the degree of Doctor of Philosophy (PhD) Johannesburg, September 2015<br>Broadly neutralizing antibodies are capable of neutralizing a large number of HIV-1 strains and have shown to be protective against infection in non-human primate models. These antibodies are likely to play an important role in an effective vaccine against HIV. Eliciting them by vaccination has thus far been unsuccessful and their unusual features such as long CDHR3 lengths and high levels of

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14

Wierzbicka, Marta. "Investigation of a Putative Secondary Binding Site between the Broadly Neutralizing Monoclonal anti-HIV-1 Antibody and its Antigen gp41." Thesis, 2010. http://hdl.handle.net/1807/25513.

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One potential approach to vaccine development against HIV involves generating an immunogen that can elicit the production of broadly neutralizing monoclonal antibodies (bnmAbs), which target specific sites on the HIV-1 envelope. Using site-directed mutagenesis and ELISA assays, this thesis investigates the idea of a secondary binding site of one of the bnmAbs, 2F5, as suggested by previous studies that identified residues Asp64, Thr65, and Arg82B on 2F5 that are recognized by its anti-idiotypic antibody 3H6. Results show that 2F5 binds only very weakly to the gp41 ectodomain in its post-fusion

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15

Registre, Ludy. "Examination of the role of envelope directed antibodies on co-receptor usage in HIV-1B infection." Thesis, 2018. https://hdl.handle.net/2144/29958.

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HIV-1 primarily utilizes the CCR5 receptor as a co-receptor, but over time, viruses can evolve to use the CXCR4 protein. Changes in the viral envelope V3 loop mediate this switch. The emergence of CXCR4-utilizing viruses has been presumed to occur as a consequence of decreased humoral immunity. We show that exclusively CXCR4-using (X4) viruses contain a 2 to 3 amino acid insertion in the V3 loop. Structural modeling revealed that this insertion caused a protrusion in the V3 loop, which impacts CCR5 receptor interaction. These genotypic and structural motifs affected neutralization susceptibili

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16

Wu, Ji Hung, and 吳季鴻. "Influenza virus-like particles by glycan masking and unmasking of hemagglutinin antigens to induce broadly neutralizing antibodies against H5N1 avian influenza viruses." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/mp5km4.

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17

Niessl, Julia. "Modulation of HIV-specific T cell responses during standard antiretroviral treatment and immunotherapy." Thesis, 2020. http://hdl.handle.net/1866/24606.

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Seule une minorité des individus infectés par le virus de l’immunodéficience humaine (VIH) développe une réponse immunitaire capable de contrôler le virus. Chez la plupart des individus, on observe un échappement virologique et un épuisement des lymphocytes T CD8+ spécifiques du VIH. L’infection chronique non-traitée altère également les lymphocytes T CD4+ spécifiques du VIH caractérisé par l’expression accrue des récepteurs co-inhibiteurs et une signature des cellules auxiliaires T folliculaires (Tfh). La thérapie antirétrovirale (TAR) est très efficace pour supprimer durablement la charge vi

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