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1

Barbara, Juknialis, ed. Inhaled aerosol bronchodilators. Baltimore: Williams & Wilkins, 1986.

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2

L, Rau Joseph, ed. Rau's respiratory care pharmacology. 8th ed. St. Louis, Mo: Elsevier/Mosby, 2012.

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3

W, Jenne J., and Murphy Shirley 1944-, eds. Drug therapy for asthma: Research and clinical practice. New York: Dekker, 1987.

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4

Friedrich, Kummer, ed. Asthma: Structural body-Theophylline today = strukturelle Grundlagen--Theophyllin heute. New York: Springer-Verlag, 1995.

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5

Dietz, D. NTP technical report on the toxicology and carcinogenesis studies of l-Epinephrine hydrochloride (CAS No. 55-31-2) in F344/N rats and B6C3F1 mice (inhalation studies). Research Triangle Park, NC: U.S. Dept. of Health and Human Services, Public Health Service, National Institutes of Health, 1990.

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6

Jubber, Akeel Shamkhi. Assessment of measures of airway responsiveness and their use in the evaluation of bronchodilator drugs. Manchester: University of Manchester, 1993.

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7

Nageeb A.G.M Hassan. Evaluation of airway pharmacodynamic and pharmacokinetic properties of bronchoconstrictor and bronchodilator drugs in normal human subjects. Manchester: University of Manchester, 1993.

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8

Bills, Georgine W. Principles of pharmacology for respiratory care. 2nd ed. Albany: Delmar Publishers, 1997.

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9

C, Soderberg Robert, ed. Principles of pharmacology for respiratory care. Albany, N.Y: Delmar Publishers, 1994.

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10

Zug, Naser Abd-Asalam. Studies of the bronchodilator action of the long acting [beta]2-agonist (salmeterol) in normal human subjects. Manchester: University of Manchester, 1997.

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11

L, Rau Joseph, ed. Respiratory care pharmacology. 3rd ed. Chicago: Year Book Medical Publishers, 1989.

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12

Respiratory care pharmacology. 4th ed. St. Louis: Mosby, 1994.

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13

Respiratory care pharmacology. 5th ed. St. Louis: Mosby, 1998.

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14

Romain, Pauwels, and O'Byrne Paul M. 1951-, eds. Beta₂-agonists in asthma treatment. New York: Dekker, 1997.

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15

Gardenhire, Douglas S. Rau's respiratory care pharmacology. 7th ed. St. Louis, Mo: Mosby Elsevier, 2008.

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16

Bronze Age landscape and society in Southern Epirus, Greece. Oxford, England: Archaeopress, 2004.

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17

1944-, Costello J. F., and Royal Society of Medicine (Great Britain). Respiratory Section., eds. Sympathomimetic enantiomers in the treatment of asthma: The proceedings of a meeting held by the Respiratory Section of the Royal Society of Medicine, London, October 1995. New York: Parthenon Pub. Group, 1997.

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18

Bronchodilator Therapy. F. A. Davis Company, 1986.

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19

Workbook For Raus Respiratory Care Pharmacology. Mosby, 2011.

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20

Barnes, P. J., Clive P. Page, K. F. Chung, A. G. Alexander, and Peter J. Barnes. Pharmacology of Asthma. Springer London, Limited, 2012.

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21

Barnes, P. J., Clive P. Page, K. F. Chung, A. G. Alexander, and Peter J. Barnes. Pharmacology of Asthma. Springer London, Limited, 2012.

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22

Zimmer, Brian. The pharmacoeconomic and clinical effects of a change in perioperative bronchodilator use. 1992.

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23

Formoterol: Fast and long-lasting bronchodilatation : proceedings of an international symposium sponsored by Ciba-Geigy Limited, held during the First Annual Congress of the European Respiratory Society (ERS), Brussels, September 1991. London: Royal Society of Medicine Services, 1992.

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24

Johnson, Neil G. A study of alternate methods of inhaled bronchodilator administration in hospitalized medical patients. 1988.

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25

J, Davies Robert, and European Society of Pneumology. Congress, eds. Formoterol: Clinical profile of a new long-acting inhaled [beta]2-agonist : an international symposium held during the VIIth Congress of the European Society of Pneumology (SEP), Budapest, 1988. Toronto: Hogrefe & Huber, 1990.

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26

Davies, R. J. Formoterol - Clinical Profile of a New Long -. Hogrefe & Huber Publishers, 1991.

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27

Foundation, Medicine Publishing, ed. Inspiration: Development in inhalation therapy. Published for the Medicine Publishing Foundation by the Medicine Group, 1989.

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28

L'économie des Matières Premières de la Pierre Taillée d'Anatolie Centrale Au Chalcolithique Ancien: L'étude de Cas De Çatalhöyük-Ouest. British Archaeological Reports Limited, 2016.

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29

Formoterol: A Long Acting B2-Agonist for the Management of Asthma : An International Symposium Held During the Joint Meeting of Sep and Sepcr, London. Hogrefe & Huber Pub, 1991.

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30

1936-, Saunders Kenneth B., European Society for Clinical Respiratory Physiology., and European Society of Pneumology, eds. Formoterol: A long-acting B2-agonist for the management of asthma : an international symposium held during the joint meeting of SEP and SEPCR, London, 1990. Seattle: Hogrefe & Huber, 1992.

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31

Formoterol. Hogrefe & Huber Pub, 1991.

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32

1946-, Barnes Peter J., Matthys Heinrich, and European Society of Pneumology. Congress, eds. Formoterol--a new-generation [beta] 2-agonist: An international symposium held during the 8th Congress of the European Society of Pneumology, Freiburg, Federal Republic of Germany, September 1989. Toronto: Hogrefe & Huber, 1991.

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33

1943-, Sybrecht Gerhard, and World Congress of Asthmology (12th : 1987 : Barcelona, Spain), eds. Formoterol, a new long-acting bronchodilator: An international symposium held during the XIIth World Congress of Asthmology, Barcelona, 1987. Toronto: Hans Huber Publishers, 1988.

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34

Cass, Lindy. Intraoperative Wheezing. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199764495.003.0020.

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Wheezing is an important sign for anesthesiologists. At the preoperative consult it usually indicates bronchospasm from poorly controlled asthma, though many other causes are possible. Intraoperative wheezing also has many potential causes, including bronchospasm, airway obstruction, anaphylaxis, or aspiration. Intraoperative wheezing is an anesthetic emergency that can lead to life-threatening respiratory and cardiac complications. Prompt action to maintain oxygenation, removal of any trigger factors, and, if indicated, bronchodilator administration will usually result in a safe outcome.
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35

Respiratory Care Pharmacology. 6th ed. Mosby, 2002.

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36

Costabel, U. Atlas of Bronchoalveolar Lavage. A Hodder Arnold Publication, 1999.

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37

The effect of salbutamol on performance in elite non-asthmatic athletes. 1990.

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38

K, Shukla Vijay, and Canadian Coordinating Office for Health Technology Assessment, eds. Long-acting β₂₋agonists for maintenance therapy of stable chronic obstructive pulmonary disease : ba systematic review / cVijay K. Shukla...[et al.]. Ottawa: Canadian Coordinating Office for health Technology Assessment, 2002.

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39

Dhand, Rajiv, and Michael McCormack. Bronchodilators in critical illness. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0033.

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Inhaled beta-agonists and anticholinergic agents, as well as systemically administered methylxanthines, are frequently employed to achieve bronchodilation in critically-ill patients. Inhaled agents are given by pressurized metered dose inhaler (pMDI), nebulizer, or dry powder inhaler. In ventilator-supported patients, aerosolized agents are generally only administered by pMDI or nebulizer. The ventilator circuit, artificial airway, and circuit humidity complicate the delivery of aerosolized agents, and there is a wide variability in drug delivery efficiency with various bench models of mechanical ventilation. Aerosolized drug by pMDI is affected by the use of spacer devices, synchronization of pMDI actuation and ventilator breath delivery, and appropriate priming of the pMDI device. The efficiency of aerosolized drug delivery by jet nebulization is also affected by device placement in the circuit, as well as by a number of other factors. Several investigators have demonstrated comparable efficiency of aerosol delivery with mechanically-ventilated and ambulatory patients when careful attention is given to the technique of administration. Appropriate administration of aerosolized bronchodilators in patients receiving invasive or non-invasive positive pressure ventilation produces significant therapeutic effects.
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40

Directions for new anti-asthma drugs. Basel: Birkhauser, 1988.

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41

G, Alexander A., Page C. P, and Barnes Peter J. 1946-, eds. Pharmacology of asthma. Berlin: Springer-Verlag, 1991.

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42

R, O'Donnell Stella, Persson C. G. A, and International Congress of Pharmacology, (10th : 1987 : Sydney, N.S.W.), eds. Directions for anti-asthma drugs. Boston: Birkhauser, 1988.

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43

Anticholinergic Agents in the Upper and Lower Airways (Lung Biology in Health and Disease). Informa Healthcare, 1999.

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44

(Editor), Romain Pauwels, and Paul O'Byrne (Editor), eds. Beta 2-agonists in Asthma Treatment (Lung Biology in Health and Disease). Informa Healthcare, 1997.

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45

Dr, Johnson Malcolm, Small Roger, British Pharmacological Society Meeting, and Glaxo Group Research Limited, eds. [Beta]-adrenoceptor agonists and the airways: Held as satellite meeting to the British Pharmacological Society Meeting, School of Biological Sciences, University of Manchester, 12-15 April 1994. London: Royal Society of Medicine Press, 1995.

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46

Johnson, Malcolm, and Roger Small. Beta-Adrenoceptor Agonists and the Airways. Royal Society of Medicine Press Ltd, 1995.

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47

Tuxen, David V. Pathophysiology and causes of airflow limitation. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0110.

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Exacerbations of asthma or chronic obstructive pulmonary disease (COPD) can be life-threatening emergencies, and require careful management to minimize the risks of morbidity and mortality. Prompt, full bronchodilator therapy, careful observation and appropriate mechanical ventilation technique is required. Dynamic hyperinflation of the lungs occurs in all patients, and must be careful assessed and regulated. Excessive dynamic hyperinflation can result in respiratory tamponade, hypotension, circulatory failure, pneumothoraces and, in severe cases, cardiac arrest. Intravenous or continuous nebulized salbutamol commonly causes lactic acidosis that should be detected and managed. Prolonged paralysis during difficult mechanical ventilation can result in severe necrotizing myopathy. Pneumothoraces in ventilated patients with asthma are usually under tension, redistribute ventilation to the contralateral lung, and risk a second tension pneumothorax. Patients surviving mechanical ventilation for asthma and COPD have an increased risk of recurrence and death. All these problems require awareness, avoidance or detection and management
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48

Rau's Respiratory Care Pharmacology. Elsevier - Health Sciences Division, 2015.

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49

Rau's Respiratory Care Pharmacology. 7th ed. Mosby, 2007.

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50

S, Gardenhire Douglas, and Rau Joseph L, eds. Rau's respiratory care phamacology. 7th ed. St. Louis, Mo: Mosby/Elsevier, 2008.

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