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Dissertations / Theses on the topic 'Brow adipose tissue'

Author: Grafiati

Published: 10 September 2021

Last updated: 29 July 2025

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1

Deiuliis, Jeffrey Alan. "The metabolic and molecular regulation of adipose triglyceride lipase." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1185546165.

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2

Lean, M. E. J. "Brown adipose tissue in humans." Thesis, University of Cambridge, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.333609.

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3

Leite, Juliana Paula 1982. "O efeito do treinamento físico sobre a resistência à insulina em animais tratados com dieta hiperlipídica : modulações de fatores inflamatórios sobre o tecido adiposo branco e marrom de ratos Wistar." [s.n.], 2014. http://repositorio.unicamp.br/jspui/handle/REPOSIP/312926.

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Orientadores: Mario José Abdalla Saad, Alexandre Gabarra de Oliveira<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-25T23:51:50Z (GMT). No. of bitstreams: 1 Leite_JulianaPaula_M.pdf: 4915396 bytes, checksum: 09ea43792fb47457eab9ac0df46c3416 (MD5) Previous issue date: 2014<br>Resumo: A obesidade representa o maior fator de risco para o desenvolvimento de doenças como diabetes tipo 2, dislipidemia, esteatose hepática, doenças vasculares e alguns tipos de cânceres. Embora o aumento do tecido adiposo seja a prin

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4

Hansen, Ida R. "The secretome of brown adipose tissue." Doctoral thesis, Stockholms universitet, Institutionen för molekylär biovetenskap, Wenner-Grens institut, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-102934.

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Brown adipose tissue has long been known for its heat-producing capacity, but less is known about its possible effects as a secretory organ. This thesis summarizes information about presently known factors secreted from brown adipose tissue and about their actions. We were able to add factors to the list by the use of a signal-sequence trap method. Results from the signal-sequence trap generated a list of suggested brown adipocyte secreted proteins; gene expression of these proteins was then further studied with microarray technique. One of the genes further analyzed was the adipokine chemerin

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5

Carvalho, Aline Penna de. "Efeitos pleiotrópicos da telmisartana nos tecidos adiposos branco e marrom: aumento da expressão gênica e proteica pan-PPAR em camundongos obesos." Universidade do Estado do Rio de Janeiro, 2014. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=7337.

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Receptores ativadores de proliferação perixossomal(PPARs) são fatores de transcrição envolvidos com a oxidação dos ácidos graxos e proliferação celular, mediando diversas vias, o que representa uma estratégia promissora para enfrentar as características da síndrome metabólica. Existem três isoformas de PPARs(PPARalfa, beta/delta e gama), que são diferencialmente expressos em diferentes tecidos.No presente estudo, objetivou-se avaliar os efeitos pleiotrópicos da telmisartana, um anti-hipertensivo, bloqueador do receptor AT1 da angiotensina e agonista parcial PPAR gama, no tecido adiposo branco

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6

Sarapio, Elaine. "Estudo da ação do hormônio peptídico stanniocalcina sobre o metabolismo de lipídios." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2014. http://hdl.handle.net/10183/101653.

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As stanniocalcinas (STC1 e STC2) são hormônios glicoproteicos identificados primeiramente em peixes ósseos, relacionados com o metabolismo do cálcio e fosfato. Recentes descobertas evidenciaram que as funções das STCs foram mantidas em mamíferos. A descoberta da localização do receptor para STC1 na membrana mitocondrial de roedores e sua ação como desacopladora da respiração celular sinalizam fortemente um importante papel desse hormônio no metabolismo intermediário de mamíferos. A STC estimula a lipogênese no tecido hepático e muscular de ratos, porém, suas ações sobre o metabolismo do tecido

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7

Warncke, Urszula Osinska. "Profiling Fatty Acid Composition of Brown Adipose Tissue, White Adipose Tissue and Bone Marrow Adipose Tissue of Healthy and Diet-Induced Obese Mice." Wright State University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=wright1440097081.

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8

Mattsson, Charlotte L. "Role of caveolin-1 in brown adipose tissue." Doctoral thesis, Stockholm : The Wenner-Gren Institute, Stockholm University, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-37125.

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Diss. (sammanfattning) Stockholm : Stockholms universitet, 2010.<br>At the time of the doctoral defense, the following papers were unpublished and had a status as follows: Paper 1: Manuscript. Paper 3: Manuscript. Paper 4: Manuscript. Härtill 4 uppsatser.

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9

Robb, Louise. "The effect of exercise on rat brown adipose tissue." Thesis, University of Ottawa (Canada), 1989. http://hdl.handle.net/10393/5739.

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10

Gibbins, J. M. "Hormonal control of carbohydrate metabolism by brown adipose tissue." Thesis, University of Bristol, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.375016.

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11

Clark, Lynne. "Manipulation and control of thermoregulation in the newborn lamb." Thesis, University of Reading, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.239505.

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12

Shaikh, Muhammad Iqbal. "Alpha-2 adrenoreceptors in brown adipose tissue of infant rats." Thesis, University of British Columbia, 1986. http://hdl.handle.net/2429/27195.

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This thesis consists of five chapters. The first chapter deals with general background and introduction. Each of the subsequent chapters are divided into sections. The first section deals with pharmacological characterization of ∝₂-adrenoceptors using various ligands. The second section pertains to the study of binding characteristics of ∝₂-adrenoceptors following chemical sympathectomy by 6-hydroxydopamine and chronic blockade of ∝₂-adrenoceptors by yohimbine injections. The third section deals with the study of guanylate cyclase system in relation to ∝₂-adrenoceptors stimulation in brown fat

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13

Park, Ian R. A. "Studies of the growth and regulation of brown adipose tissue." Thesis, University of Ottawa (Canada), 1989. http://hdl.handle.net/10393/5700.

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14

Harper, Mary Ellen. "Ion transport and brown adipose tissue activity in energy balance." Thesis, University of Ottawa (Canada), 1991. http://hdl.handle.net/10393/7486.

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The objective of this work was to study the activity of the Na$\sp+$,K$\sp+$ pump and the thermogenic activity and capacity of brown adipose tissue (BAT) under conditions of dietary energy deficit and surfeit in both human subjects and laboratory animals. While controversial, it had earlier been hypothesized that Na$\sp+$,K$\sp+$ pump activity (1) acts as a "metabolic pacemaker" in the control of cellular energy expenditure, and (2) "adapts" during undernutrition so that overall energy expenditure is decreased. That BAT thermogenic activity increases during overfeeding and decreases during und

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15

Oguri, Yasuo. "Tetrahydrobiopterin activates brown adipose tissue and regulates systemic energy metabolism." Kyoto University, 2018. http://hdl.handle.net/2433/232086.

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16

von, Essen Gabriella. "Energy flow and metabolic efficiency attributed to brown adipose tissue." Doctoral thesis, Stockholms universitet, Institutionen för molekylär biovetenskap, Wenner-Grens institut, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-140190.

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The large capacity of brown adipose tissue (BAT) to expend energy as heat makes it an interesting potential player in weight regulation and other metabolic conditions. This is of particular interest as it has been recognized that adult humans possess BAT. The protein responsible for the heat production is uncoupling protein 1 (UCP1), which, as the name implies, uncouples the respiratory chain from ATP production; instead heat is produced. Cold is the strongest recruiter and activator of BAT. However, also obesogenic food has a low but nonetheless significant effect on the recruitment and activ

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17

Thomas, Joanna. "Brown adipose tissue a potential early biomarker of metabolic syndrome /." Diss., [La Jolla] : University of California, San Diego, 2009. http://wwwlib.umi.com/cr/ucsd/fullcit?p3356437.

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Thesis (Ph. D.)--University of California, San Diego, 2009.<br>Title from first page of PDF file (viewed July 9, 2009). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references.

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18

Tran, Khanh-Van T. "Origin of White and Brown Adipose Cells From Vascular Endothelium: A Dissertation." eScholarship@UMMS, 2012. https://escholarship.umassmed.edu/gsbs_diss/591.

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Obesity is associated with insulin resistance, dyslipidemia, and cardiovascular disease. The current obesity epidemic is the result of surplus energy consumption. Excess energy is stored in expanding adipose tissue. Adipose tissue growth entails the enlargement of existing adipocytes, the formation of new fat cells from preexisting progenitors, and the coordinated development of supporting vasculature. Identifying adipocyte progenitors and the mechanism of adipose tissue expansion is crucial for the development of new strategies to combat obesity and its complications. Though important progres

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19

Sabaté, Pérez Alba. "Regulation of brown adipose tissue metabolism by TP53INP2 = Regulació del metabolisme del teixit adipós marró per mitja de TP53INP2." Doctoral thesis, Universitat de Barcelona, 2019. http://hdl.handle.net/10803/668259.

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Overweight and obesity have increased dramatically during recent decades becoming a major health problem for which therapeutic options are limited. Thus, there is an urgent need to develop new safe pharmacological therapies. Obesity results from the positive imbalance resulting from the increase of energy intake and/or decrease in energy expenditure, the latter consequence of impaired processes involved in basal metabolism, adaptive thermogenesis or associated with sedentary behaviour. The excess of energy is preferentially stored in white adipose tissue (WAT) within unilocular adipocytes. An

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20

Melnyk, Anna. "Brown adipose tissue atrophy, effects on energy expenditure and body composition." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ28359.pdf.

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21

Mercer, S. W. "Studies on lipogenesis and thermogenesis in brown adipose tissue of rodents." Thesis, University of Cambridge, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.332436.

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22

Reddy, Narendra Lakshmana. "Novel insights in imaging and function of human brown adipose tissue." Thesis, University of Warwick, 2014. http://wrap.warwick.ac.uk/69397/.

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Phenomenal rise in prevalence of obesity and its complications has made it imperative to tackle the issue on a war footing, especially given the failure of current life style and medical approaches. Clearly, alternate means of treating obesity need to be explored. In contrast to white adipose tissue (WAT), which stores excess energy, brown adipose tissue (BAT) dissipates chemical energy in the form of heat by uncoupling oxidative phosphorylation from electron transport chain, to maintain body temperature homeostasis. Recent revelation of functionality of BAT in adult humans provides an excelle

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23

Ojha, Shalini. "Pericardial fat is a nutritionally regulated depot of brown adipose tissue." Thesis, University of Nottingham, 2015. http://eprints.nottingham.ac.uk/30678/.

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Introduction: Obesity and related cardio-metabolic complications have acquired global epidemic proportions. Suboptimal nutritional environment in early life induces adaptations in energy homeostasis, metabolism and adipose tissue development that may confer short-term survival advantages but are detrimental in later life, particularly if nutrient supply is restored. Brown adipose tissue (BAT) has a unique role in energy homeostasis because it can provide a potential compensatory mechanism against excess weight gain via cold or diet-induced adaptive thermogenesis. Brown adipocytes also have a p

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24

Nnodim, J. O. "Morphological studies on the development and the control mechanisms of brown adipose tissue." Thesis, Bucks New University, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.356211.

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25

Kuhn, Emmanuelle. "Impact du récepteur minéralocorticoïde sur le métabolisme énergétique." Thesis, Paris 11, 2014. http://www.theses.fr/2014PA11T050.

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En dehors de son rôle dans la régulation de la balance hydrosodée, le récepteur minéralocorticoïde (MR) est un facteur de transcription hormono-dépendant qui exerce des effets pro-adipogéniques et anti-thermogéniques in vitro, mais son rôle dans la régulation du métabolisme énergétique in vivo n’a jamais été précisément étudié. Dans ce travail, nous avons montré que les souris surexprimant le MR humain (Tg) ont une résistance à l’obésité induite par le régime hyperlipidique. Ceci s’accompagne d’un défaut de développement de la masse adipeuse comme en témoignent des surfaces adipocytaires plus

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26

Quesada, López Tania Paloma. "The role of the G-protein coupled receptor 120 (GPR120) on the FGF21 system in white and brown adipose tissues." Doctoral thesis, Universitat de Barcelona, 2018. http://hdl.handle.net/10803/662931.

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Obesity prevalence has tripled in the last fifty years. For this reason, it is considered the pandemic of the century. It is characterized by the accumulation of metabolic abnormalities triggered by an increase in the size of fat depots in the body. Hence, new therapies to pursue an amelioration of metabolic abnormalities and adipose tissue dysfunction caused by this energy imbalance are being explored. The tissue responsible for the storage of fat is adipose tissue and it was considered just as an energy reservoir until recently. Currently, it is known to be actively involved in energy homeos

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27

Rodó, Morera Jordi. "Transcriptomic analysis of white and brown adipose tissue during non-shivering thermogenesis." Doctoral thesis, Universitat Autònoma de Barcelona, 2019. http://hdl.handle.net/10803/667915.

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L’obesitat i la diabetis tipus 2 (DT2) són dues malalties estretament relacionades que representen un greu problema de salut, social i econòmic per la seva alta prevalença a tot el món. Ambdues malalties també es relacionen amb altres patologies que presenten una mortalitat elevada. Les teràpies disponibles actualment no són del tot efectives. Per tant, el desenvolupament de noves estratègies terapèutiques per a l'obesitat i la DT2 és crucial. El teixit adipós s'ha definit com un òrgan que té un paper central en el control del balanç energètic. El descobriment de funcions endocrines i termogè

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28

Cui, Jingying. "Role of sensory nerves in growth and thermogenesis of brown adipose tissue." Thesis, University of Ottawa (Canada), 1992. http://hdl.handle.net/10393/7655.

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The original objective of work described in this thesis was to study neural control of diet-induced thermogenesis in BAT. The hypothesis was that impairment of central warmth perception by capsaicin-desensitization (CAP-DES) would diminish central suppression of BAT thermogenesis by heat generated as a consequence of food ingestion, and thus enhance sympathetic-mediated diet-induced hypertrophy of BAT. Unexpectedly, CAP-DES caused atrophy of BAT and prevented diet-induced thermogenesis in BAT. This novel finding led to a modification of objectives to find out why CAP-DES induces atrophy of BAT

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29

Chen, Hsiang Yin. "The regulation of brown adipose tissue gene expression in HIB-1B cells." Thesis, University of Nottingham, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.575158.

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The main objective of this thesis is to contribute to our understanding of the regulation of brown adipose gene expression by examining the transcriptional regulation of the two key brown adipogenic genes, UCPl and PGCla during the initial stage of differentiation in a model brown adipocyte cell line. The principal findings were that UCP land PGC 1 a expression was induced by both forskolin and rosiglitazone, and that combination of these drugs produced a synergistic increase which required the full length promoters. These effects on UCPl and PGCla expression were partially suppressed by PKA a

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30

Peachey, Tamsin Jane. "Regulation and organisation of the mitochondrial uncoupling protein from brown adipose tissue." Thesis, University of Southampton, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.278638.

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31

KUO, HSUAN-CHIH. "Apolipoprotein A-IV Enhances Thermogenesis in Brown Adipose Tissue and Energy Expenditure." Ohio University / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1628701770248129.

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32

Ueta, Cintia Bagne. "Papel dos receptores adrenérgicos b1 e b2 na termogênese facultativa." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/42/42131/tde-02062009-160236/.

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O peso corporal dos animais tende a ser relativamente estável durante longos períodos de tempo. Situações de restrição calórica ou aumento na ingestão de calorias levam a alterações fisiológicas compensatórias que resistem aos efeitos destas perturbações. De fato, o gasto energético aumenta em animais submetidos à dieta hipercalórica, a chamada termogênese facultativa, de modo a manter os estoques energéticos constantes. É possível que defeitos na termogênese facultativa estejam envolvidos no desenvolvimento da obesidade. O BAT, o principal sítio de termogênese facultativa, é ativado pela libe

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33

Leung, Tsz-mei, and 梁紫微. "Prevalence and factors associated with brown adipose tissue detected by 18F-FDG PET/CT in Hong Kong Chinese." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B49617539.

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Brown adipose tissue (BAT) is a unique organ in existence in mammals. It can induce non-shivering thermogenesis to control body temperature and energy balance through the expression of uncoupling protein 1 (UCP1). In our study, we aimed to evaluate the prevalence of BAT, as detected by fluorine 18-fluorodeoxyglucose (18F-FDG) positron emission tomography combined computer tomography (PET/CT), in a Hong Kong Chinese population. We also assessed the influence of age and sex to BAT in Hong Kong Chinese population. We also determined the factors associated with it, in particular, its relationship

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34

Eley, Judy. "The control of brown adipose tissue function in mice with goldthioglucose-induced obesity." Thesis, University of Ottawa (Canada), 1988. http://hdl.handle.net/10393/5472.

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35

Sigurdson, S. Lynn. "Control of brown adipose tissue growth and function in normal and myopathic hamsters." Thesis, University of Ottawa (Canada), 1989. http://hdl.handle.net/10393/5567.

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36

Liu, Yang. "Neural Crosstalk Between Sympathetic Nervous System and Sensory Circuits to Brown Adipose Tissue." Digital Archive @ GSU, 2013. http://digitalarchive.gsu.edu/biology_theses/44.

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Brown adipose tissue (BAT) is a critical organ for non-shivering thermogenesis, which is under control of both sympathetic and sensory neural innervation. We utilized both a retrograde sympathetic nerve tract tracer pseudorabies virus and an anterograde sensory tract tracer the H129 strain of herpes simplex virus-1 to locate individual neurons across the neuroaxis that are part of the SNS outflow from brain to interscapular BAT and are part of the sensory input to the brain. We found specific neuronal phenotype of the double-infected neurons distributed from the hindbrain to the forebrain with

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37

Milner, Rachel Elizabeth. "Studies on the 'activity' of the uncoupling protein in brown adipose tissue mitochondria." Thesis, University of Cambridge, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.279751.

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38

EFREMOVA, AGRAFENA. "Direct and indirect evidence of brown adipose tissue in adult patients from Yakutia." Doctoral thesis, Università Politecnica delle Marche, 2019. http://hdl.handle.net/11566/263608.

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La scoperta del tessuto adiposo bruno nell’uomo ha destato un grande interesse in quanto la sua induzione potrebbe rappresentare una possibilità per la cura contro l’obesità e i rischi ad essa correlati. L’esposizione al freddo è uno degli stimoli principali che determina la trasformazione degli adipociti bianchi in bruni (fenomeno del browning). Sulla base di studi promettenti svolti sui topi, abbiamo analizzato, anche nell’uomo, la capacità delle cellule mononucleate del sangue periferico di esprimere biomarkers del browning. Infatti, poiché le tecniche di studio del tessuto adiposo bruno so

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39

Go, Gus Adi Gunawan. "Adrenomedullin in adipose tissues : differences between white and brown fats and the effects of adrenergic stimulation /." View the Table of Contents & Abstract, 2005. http://sunzi.lib.hku.hk/hkuto/record/B31362047.

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40

Pence, Sydney W. "Novel regulation of BAT thermogenesis induced by hypothalamic Apolipoprotein AIV." Ohio University Honors Tutorial College / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=ouhonors1524828526830907.

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41

Sherman, Shermel B. "Tibia Morphology & Bone Marrow Adipose Tissue Phenotype is Controlled by Sex Steroids in C57BL/6 Mice." University of Toledo Health Science Campus / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=mco1461972446.

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42

Troike, Katie M. "White Adipose Tissue Beiging in Mice With Increased Growth Hormone Action." Ohio University / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1497354961246326.

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43

Kates, Anna-Lisa. "Thyroid hormone metabolism in brown adipose tissue of lean and genetically obese (OBOB) mice." Thesis, University of Ottawa (Canada), 1989. http://hdl.handle.net/10393/21547.

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44

Go, Gus Adi Gunawan, and 吳蕓宇. "Adrenomedullin in adipose tissues: differences between white and brown fats and the effects ofadrenergic stimulation." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2005. http://hub.hku.hk/bib/B4501002X.

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45

Giroud, Maude. "Implication des microARNs dans la conversion des adipocytes blancs en adipocytes thermogéniques." Electronic Thesis or Diss., Nice, 2015. http://www.theses.fr/2015NICE4082.

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La découverte récente d'adipocytes bruns fonctionnels chez les humains adultes a conduit à envisager leur utilisation afin d’augmenter la dépense énergétique dans de potentiels traitements contre l'obésité et les maladies associées. Par ailleurs, des ilots d’adipocytes bruns, appelés adipocytes "brite" (brown in white), émergent dans le tissu adipeux blanc après une exposition au froid ou une stimulation des récepteurs β3-adrénergiques. En utilisant les cellules hMADS, nous avons identifié plusieurs miARNs régulés pendant le « britening ». miR-125b et let-7i ont des niveaux d’expression plus b

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46

Mössenböck, Karin [Verfasser], and Stephan [Akademischer Betreuer] Herzig. "A Story in Brown and White Regulation of Metabolic Homeostasis by Brown Adipose tissue / Karin Mössenböck ; Betreuer: Stephan Herzig." Heidelberg : Universitätsbibliothek Heidelberg, 2016. http://d-nb.info/1180735242/34.

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47

Senol-Cosar, Ozlem. "A Role for TNMD in Adipocyte Differentiation and Adipose Tissue Function: A Dissertation." eScholarship@UMMS, 2016. https://escholarship.umassmed.edu/gsbs_diss/837.

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Adipose tissue is one of the most dynamic tissues in the body and is vital for metabolic homeostasis. In the case of excess nutrient uptake, adipose tissue expands to store excess energy in the form of lipids, and in the case of reduced nutrient intake, adipose tissue can shrink and release this energy. Adipocytes are most functional when the balance between these two processes is intact. To understand the molecular mechanisms that drive insulin resistance or conversely preserve the metabolically healthy state in obese individuals, our laboratory performed a screen for differentially regulated

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48

Senol-Cosar, Ozlem. "A Role for TNMD in Adipocyte Differentiation and Adipose Tissue Function: A Dissertation." eScholarship@UMMS, 2006. http://escholarship.umassmed.edu/gsbs_diss/837.

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Adipose tissue is one of the most dynamic tissues in the body and is vital for metabolic homeostasis. In the case of excess nutrient uptake, adipose tissue expands to store excess energy in the form of lipids, and in the case of reduced nutrient intake, adipose tissue can shrink and release this energy. Adipocytes are most functional when the balance between these two processes is intact. To understand the molecular mechanisms that drive insulin resistance or conversely preserve the metabolically healthy state in obese individuals, our laboratory performed a screen for differentially regulated

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49

Whittle, Andrew John. "A role for bone morphogenetic protein 8b in brown adipose tissue thermogenesis and energy homeostasis." Thesis, University of Cambridge, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609416.

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50

Jones, Terence A. "Characterisation and identification of brown adipose tissue on positron-emission tomography and magnetic resonance imaging." Thesis, University of Warwick, 2015. http://wrap.warwick.ac.uk/71009/.

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Characterisation and identification of brown adipose tissue on positron-emission tomography and magnetic resonance imaging Since the first published description of brown adipose tissue (BAT) in 1551 its reputation has changed from that of a mere curiosity of little physiological significance in adult humans, to meriting reclassification as a metabolic organ in its own right. Obesity is a major global public health problem. Modulation of non-shivering thermogenesis through BAT manipulation presents an attractive therapeutic target for inducing weight loss. Testing the efficacy of such pharmacol

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