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Dissertations / Theses on the topic 'Bruch's membrane'

Author: Grafiati

Published: 4 June 2021

Last updated: 20 February 2023

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1

Karwatowski, Wojciech Stefan Stanislaw. "Bruch's membrane and its collagen." Thesis, University of Bristol, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.361162.

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2

Lee, Yunhee. "Characterisation and modulation of the gelatinase system of human Bruch's membrane." Thesis, King's College London (University of London), 2012. https://kclpure.kcl.ac.uk/portal/en/theses/characterisation-and-modulation-of-the-gelatinase-system-of-human-bruchs-membrane(013f751e-04af-44a8-a866-2eec03998309).html.

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Ageing of Bruch’s membrane is associated with structural and functional deterioration. Accumulation of normal and abnormal collagen in ageing Bruch’s has led to the hypothesis of diminished matrix degradation mediated normally by a family of protease enzymes called the matrix metalloproteinases (MMPs). Underlying mechanisms leading to diminished MMP activity in ageing Bruch’s remain unknown but functional changes of diminished transport are well documented. Ageing remains the biggest risk factor in AMD with nearly 30% of all individuals reaching the age of 85 years showing some loss of central

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3

Zayas-Santiago, Astrid, Samuel D. Cross, James B. Stanton, Alan D. Marmorstein, and Lihua Y. Marmorstein. "Mutant Fibulin-3 Causes Proteoglycan Accumulation and Impaired Diffusion Across Bruch's Membrane." ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2017. http://hdl.handle.net/10150/624956.

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PURPOSE. The mutation R345W in EFEMP1 (fibulin-3) causes macular degeneration. This study sought to determine whether proteoglycan content and diffusion across Bruch's membrane are altered in Efemp1(ki/ki) mice carrying this mutation or in Efemp1(-/-) mice. METHODS. Proteoglycans in mouse Bruch's membranes were stained with Cupromeronic Blue (CB). Heparan sulfated proteoglycan (HSPG) and chondroitin/dermatan sulfate proteoglycan (C/DSPG) distributions were visualized following treatments with chondroitinase ABC (C-ABC) or nitrous acid. Total sulfated glycosaminoglycans (sGAGs) in Bruch's membr

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4

Moore, David Jonathan. "An investigation of the permeability of Bruch's membrane and its variation with age." Thesis, King's College London (University of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.338867.

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5

Haneef, Atikah Shahid. "Fabrication of novel cytocompatible membranes for ocular application, concentrating in particular on age-related macular degeneration (AMD)." Thesis, University of Manchester, 2014. https://www.research.manchester.ac.uk/portal/en/theses/fabrication-of-novel-cytocompatible-membranes-for-ocular-application-concentrating-in-particular-on-agerelated-macular-degeneration-amd(7d1ace68-09d8-4c64-83e7-3ede1e2f52e1).html.

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The aims of this research were to investigate polymer fibre morphology, overall mat morphology, mechanical properties and general handling of the mats, and ideal mat thickness in order to fabricate a suitable substrate for potential use in cell transplantation for application as a permanent substrate for the treatment of dry age-related macular degeneration (AMD). Polystyrene (PS), poly(ethylene terephthalate) (PET) and polyurethane (PU) were electrospun to ascertain the ideal electrospinning parameters to reproducibly obtain fibres to construct a mat as a potential candidate for a replacement

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6

Duvall-Young, Josephine. "New concepts in the pathophysiology of macular disease : morphological responses in the choriocapillaris and Bruch's membrane." Thesis, University of Edinburgh, 1988. http://hdl.handle.net/1842/18853.

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7

Starita, Carla. "An investigation of the site of resistance to fluid transport within Bruch's membrane and changes with age." Thesis, King's College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.250686.

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8

Ahir, Alpa. "An investigation of matrix metalloproteinases derived from retinal pigment epithelial cells and their influence on fluid movement through Bruch's membrane." Thesis, King's College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.274921.

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9

Hodgetts, Andrea. "An investigation of the changes in fibre and matrix components of human Bruch's membrane as a function of age and their implications for movement of fluids." Thesis, King's College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.246304.

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10

Shadforth, Audra M. "Development of a cultured tissue substitute to repair the ageing retina." Thesis, Queensland University of Technology, 2015. https://eprints.qut.edu.au/90058/12/Audra_Shadforth_Thesis.pdf.

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This project provides a foundation for the use of silk membranes in a tissue engineered therapy for the treatment of devastating retinal diseases such as age-related macular degeneration. The three-dimensional tissue model described in this thesis has great potential for use in basic research of retinal pathologies, and the potential to be implemented into clinical approaches after appropriate refinement.

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11

Cherepanoff, Svetlana. "Age-related macular degeneration: histopathological and serum autoantibody studies." University of Sydney, 2008. http://hdl.handle.net/2123/2464.

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Doctor of Philosophy (PhD)<br>BACKGROUND: The accumulation of abnormal extracellular deposits beneath the retinal pigment epithelium characterises the pathology of early age-related macular degeneration. However, the histopathological threshold at which age-related changes become early AMD is not defined, and the effect of each of the deposits (basal laminar deposit and membranous debris) on disease progression is poorly understood. Evidence suggests that macrophages play a key role in the development of AMD lesions, but the influence of basal laminar deposit (BLamD) and membranous debris on t

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12

Ivert, Lena. "Interactions between neural retina, retinal epithelium and choroid /." Stockholm : Section of ophthalmology and vision, Department of clinical neuroscience, Karolinska institutet, 2006. http://diss.kib.ki.se/2006/91-7140-797-9/.

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13

Zeng, Ziqian. "Fabrication and Development of a PCL Electrospun Fiber - Keratin Aerogel Scaffold to Mimic Bruch’s Membrane for the Study of Age-related Macular Degeneration." Miami University / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=miami1502103996594191.

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14

Kabbara, Sami. "Comparing Optical Coherence Tomography Radial and Cube Scan Patterns for Measuring Bruch’s Membrane Opening Minimum Rim Width (BMO-MRW) in Glaucoma and Healthy Eyes: Cross-sectional and Longitudinal Analysis." Thesis, The University of Arizona, 2018. http://hdl.handle.net/10150/627199.

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A Thesis submitted to The University of Arizona College of Medicine - Phoenix in partial fulfillment of the requirements for the Degree of Doctor of Medicine.<br>Background and Significance: Spectral Domain-Optical Coherence Tomography (OCT) is one of the most widely used imaging modality in Ophthalmology. It utilizes light waves to visualize the various layers of the retina. The OCT machines offer two different scan patterns, the circular and the cube scan patters. It is important to compare these scan pattern to see if any discrepancy exist in quantifying retinal indices. One of the newer in

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15

Richert, Elisabeth [Verfasser]. "Wirkung schonender Laserverfahren auf den Komplex aus retinalem Pigmentepithel, Bruch´scher Membran und Choroidea - mögliche Therapieoption der frühen altersabhängigen Makuladegeneration / Elisabeth Richert." Kiel : Universitätsbibliothek Kiel, 2017. http://d-nb.info/1133074014/34.

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16

Gmeiner, Jonas Maximilian David [Verfasser], Christian [Akademischer Betreuer] Mardin, and Christian [Gutachter] Mardin. "Vergleich von Bruch-Membran basierter Minimaler Randsaumweite und Peripapillärer Nervenfaserschichtdicke in der Frühdiagnostik von Glaukomen / Jonas Maximilian David Gmeiner ; Gutachter: Christian Mardin ; Betreuer: Christian Mardin." Erlangen : Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 2020. http://d-nb.info/1214443451/34.

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17

"Deleterious effect of A2E in human RPE cells and Bruch's membrane." NORTHERN ILLINOIS UNIVERSITY, 2009. http://pqdtopen.proquest.com/#viewpdf?dispub=1460974.

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18

Lundkvist, Stefan. "OCT (Optical Coherense Tomography) : Teknik och tillämpning." Thesis, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-52886.

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Before year 1895, the doctors could only make a probable diagnosis based on what the patient could tell and it was hurt and there was no discernable change to the outside of the body. With X-ray, it was possible to see inside the patient without first cutting it, you can say that the X-ray was the starting point for diagnostic imaging.The further development of X-ray gave CT (Computed Tomography), where X-ray tubes and detectors rotate around the patient while the patient table moves. Besides CT also developed MRI (Magnetic Resonance Imaging), PET (Positron Emission Tomography) and Ultrasound.

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