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Journal articles on the topic 'Brucine Derivatives'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Neganova, Margarita, Yulia Aleksandrova, Alexandra Voloshina, et al. "Biological Activity Evaluation of Phenolic Isatin-3-Hydrazones Containing a Quaternary Ammonium Center of Various Structures." International Journal of Molecular Sciences 25, no. 20 (2024): 11130. http://dx.doi.org/10.3390/ijms252011130.

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A series of new isatin-3-hydrazones bearing different ammonium fragments was synthesized by a simple and easy work-up reaction of Girard’s reagents analogs with 1-(3,5-di-tert-butyl-4-hydroxybenzyl)isatin. All derivatives have been shown to have antioxidant properties. In terms of bactericidal activity against gram-positive bacteria, including methicillin-resistant strains of Staphylococcus aureus, the best compounds are 3a, 3e, and 3m, bearing octyl, acetal, and brucine ammonium centers, respectively. In addition, brucine and quinine derivatives 3l, and 3j exhibit platelet antiaggregation act

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2

Figueroa-Valverde, Lauro, Francisco Díaz-Cedillo, Elodia García-Cervera, et al. "Design and Synthesis of Two Brucine Derivatives." Asian Journal of Chemistry 25, no. 12 (2013): 6783–86. http://dx.doi.org/10.14233/ajchem.2013.14674.

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3

Figueroa-Valverde, Lauro, Francisco Díaz-Cedillo, Elodia Garcia-Cervera, Maria Lopez-Ramos, and Eduardo Pool-Gomez. "A Facile Synthesis of Two Brucine-Steroid Derivatives." Asian Journal of Chemistry 25, no. 4 (2013): 1901–4. http://dx.doi.org/10.14233/ajchem.2013.13214.

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4

Davis, M., NPB Dudman та HF White. "Preparation of (S)-3-Azidodihydrofuran-2(3H)-one(α-Azidobutyrolactone) (1), a Useful Chiral Synthon". Australian Journal of Chemistry 38, № 4 (1985): 621. http://dx.doi.org/10.1071/ch9850621.

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(S)-3-Azidodihydrofuran-2(3H)-one (α- Azidobutyrolactone ) (1) has been resolved through the brucine salt of the corresponding hydroxy acid (2). Both (1), and various derivatives of (2), are useful synthons for the preparation of L-amino acids related to L- homoserine.

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5

Çapan, İrfan, and Süleyman Servi. "Synthesis of New C2-Symmetric Chiral Benzimidazole Derivatives Having Norbornene/Dibenzobarrelene Skeletons." Letters in Organic Chemistry 17, no. 10 (2020): 801–5. http://dx.doi.org/10.2174/1570178616666190731105327.

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Racemic dicarboxylic acids were synthesized from the Diels-Alder cycloaddition reactions which formed the dibenzobarrelene and norbornene skeletons. The pure enantiomers of these compounds were obtained using brucine as the chiral auxiliary. Novel C2-symmetric chiral benzimidazole derivatives were synthesized from the reaction of the diaminobenzene and enantiomeric dicarboxylic acids in the presence of boric acid.

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6

Gharagozloo, Parviz, Sebastian Lazareno, Angela Popham, and Nigel J. M. Birdsall. "Allosteric Interactions of Quaternary Strychnine and Brucine Derivatives with Muscarinic Acetylcholine Receptors." Journal of Medicinal Chemistry 42, no. 3 (1999): 438–45. http://dx.doi.org/10.1021/jm970799y.

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7

Mudhgi, Priya, Brijendra Singh Tomar, and Satbir Kumar Chawla. "Therapeutic Properties of Kuchala – A Short Review." International Research Journal of Ayurveda & Yoga 7, no. 7 (2024): 32–36. http://dx.doi.org/10.48165/irjay.2024.70706.

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Medicinal plants are a pool of organically active compounds. In texts, there are various allusions to the use of vishdraya as a medicine. Kuchala (Strychnos nux-vomica Linn), an evergreen tree, commonly known as poison nut is attributed with both poisonous and medicinal values. Alkaloids are the main bioactive ingredients in S. nux-vomica Linn, 80% of which are strychnine and brucine, as well as their derivatives such as brucine N-oxide or isostrychnine. In Ayurveda, it has been used for curing various ailments including paralysis, dyspepsia, itching, joint pain, dysentery, emotional disorders

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8

Kirubakarababu, Merlin, and Arputharaj Samson Nesaraj. "Transition of Therapeutic to Toxicological Effects of Certain Plant Alkaloids: A Critical Review Based on their Forensic Perspective." Asian Journal of Chemistry 34, no. 7 (2022): 1613–24. http://dx.doi.org/10.14233/ajchem.2022.23604.

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The secondary metabolites have a significant property of therapy as well as toxicity. One among the secondary metabolite that is enormously present in plants is alkaloids. The occurrence of the alkaloid is found to be about 20% in the plants. These compounds have a useful therapeutic application in health disorders. On the other hand, they also cause toxicity to humans as well as animals. Their toxicity levels in humans may tend to affect the gastrointestinal and nervous systems. In this review, occurrence, synthesis and the toxicity levels of non-heterocyclic alkaloids viz. N-methyl tyramine

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9

DEHMLOW, E. V., and M. S. ROMERO. "ChemInform Abstract: Applications of Phase-Transfer Catalysis. Part 56. Experiments with Some (-)-Sparteine and (-)-Brucine Derivatives as Phase-Transfer Catalysts." ChemInform 24, no. 14 (2010): no. http://dx.doi.org/10.1002/chin.199314050.

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10

Figueroa-V, L., F. Diaz-Cedil, E. Garcia-Cer, et al. "Antimicrobial Activity Induced by A Steroid-brucine Derivative on S. typhi, K. pneumoniae and E. coli." Journal of Biological Sciences 14, no. 1 (2013): 67–72. http://dx.doi.org/10.3923/jbs.2014.67.72.

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11

Daibova, Elena B., Tamara S. Minakova, Valeriy S. Zakharenko, Natalia I. Kosova, Irina A. Kurzina, and Alla B. Zotova. "Acid-Base and Photoinduced Processes on Magnesium-Containing Minerals and their Influence on the Troposphere Cleaning." Advanced Materials Research 1085 (February 2015): 119–23. http://dx.doi.org/10.4028/www.scientific.net/amr.1085.119.

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Acid-base, adsorption and photosorption properties of microparticles surface of magnesium-containing compounds produced by dispersion of natural minerals after exposure to the air were studied. It was revealed that the reduction in predominant basicity of minerals surface in a range of periclase (MgO), brucite (Mg (OH)2) and magnesite (MgCO3) can be considered as a result of the presence of iron, silicon and magnesium oxide compounds. Quantum-chemical calculations made during the investigation, the decrease of pressure in the process of long-term contact of Freon 22 with the surface of MgO, ir

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12

Crichton, W. A., and N. L. Ross. "Equation of state of phase E." Mineralogical Magazine 64, no. 3 (2000): 561–67. http://dx.doi.org/10.1180/002646100549427.

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AbstractThe isothermal equation of state (EoS) of phase E, Mg1.96(7)Fe0.072(5)Si1.04(5)H3.7(8)O6, has been determined using high-pressure single-crystal X-ray diffraction. A third-order Birch Murnaghan EoS fit to pressue-volume data collected from room pressure and temperature to 6.7 GPa reveals that phase E has the lowest bulk modulus, KT = 92.9(7) GPa, and highest pressure derivative of the bulk modulus, K' = 7.3(2), for any dense hydrous magnesium silicate (DHMS) yet measured. A parameterized third-order Birch-Murnaghan EoS was also fit to the unit-cell parameters which display significant

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13

Mozdeika, Lukas. "Disappearance of the Self and Its Constitutive Outside in Kafka and Woody Allen's Zelig." Cultural Intertexts 10, The Roaring (20)20s (2020): 46–56. https://doi.org/10.5281/zenodo.4322229.

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Although parallels between Kafka’s hybrid characters and Woody Allen’s Leonard Zelig have been noted in literature studies (Bruce 1998), the underlying interpretative synergy is not exhausted and occasions a revisit, timely in light of the social tensions of the centurylater-present. Juxtaposing counterfactual history with actual highbrow commentary in quasi- or mockumentary film genre allows Woody Allen to transpose Kafka’s grotesque into American realm of the 20s and thus Americanize it. The contention of this article is to suggest that Leonard Zelig, a changing man, is a d

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14

Diouane, Youssra, Victor Oestreicher, Alvaro Seijas Da Silva, and Gonzalo Abellán. "Tuning the Structure of Layered Hydroxides for Boosting Energy Application Performance." ECS Meeting Abstracts MA2023-01, no. 13 (2023): 1328. http://dx.doi.org/10.1149/ma2023-01131328mtgabs.

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We are currently on a race against the clock to protect our planet from greenhouse gas emissions. The solution could be inspired from mother nature talking about renewable energies or so-called green energies including wind, solar, hydraulic, biomass and so on, which allows us to reduce the fossil fuels consumption. However, these kinds of energy devices should be coupled to an energy storage system such as batteries and supercapacitors to compensate the absence of wind and sun. For this purpose, we are looking forward to developing strong energy and power application systems by focusing on th

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15

Freeman, Kennedy J., Kerry O. Cleveland, Christopher M. Bland, and Bruce M. Jones. "1056. Safety and Tolerability of Dalbavancin in Vancomycin Allergic Patients – A Case Series." Open Forum Infectious Diseases 8, Supplement_1 (2021): S620. http://dx.doi.org/10.1093/ofid/ofab466.1250.

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Abstract Background VVancomycin and dalbavancin, both in the glycopeptide class of antibiotics, are used in the treatment of Gram-positive infections, including methicillin-resistant Staphylococcus aureus. Antibiotics in this class contain a heptapeptide core that has potential for cross-sensitivity. Due to this risk, dalbavancin carries a warning in the package insert for use in patients with a glycopeptide allergy. Dalbavancin, a semi-synthetic derivative of vancomycin, has lipophilic side chains which reduce the risk of cross-sensitivity to vancomycin. This case series evaluated patients wi

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16

Guo, Zhijun, Jianxun Lei, Joshua McCarra, et al. "Abstract LB010: C5F2-hexyl-(cuban-1-yl-methyl)-biguanide (C5F2-HCB) overcomes an immune excluded tumor microenvironment (TME) and suppresses tumor growth in the ovarian dependent ER+HER2- SSM2ucd mammary carcinoma allograft model." Cancer Research 85, no. 8_Supplement_2 (2025): LB010. https://doi.org/10.1158/1538-7445.am2025-lb010.

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Abstract Introduction: Heme-binding biguanides inhibit cytochrome P450 monooxygenase-mediated biosynthesis of the epoxy fatty acid (EpFA) (±)14,15-EET, which promotes progression of ER+HER2- breast cancer as well as regulatory T cell (Treg) proliferation. However, there are no known strategies to exploit this vulnerability. Metformin has shown promise but lacks sufficient potency and clinical utility. Through structure-based design, heme binding hexyl cubane derivatives of metformin were identified, which potently inhibited (±)14,15-EET biosynthesis. Fluorination of the hexyl moiety improved p

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17

Naboulsi, Agathe, Giao T. M. Nguyen, Odile Fichet, and Christel Laberty-Robert. "Conception of Hybrid Organic-Inorganic Membrane as New Electrolyte in All Solid-State Battery." ECS Meeting Abstracts MA2023-01, no. 6 (2023): 996. http://dx.doi.org/10.1149/ma2023-016996mtgabs.

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All-solid-state lithium batteries (ASSBs) are considered like the next generation of electrochemical energy storage devices because of their safety and their high energy density up to 400Wh/kg. The all-solid-state battery is composed of a positive electrode (e.g., NMC (Li(Ni1∕3Mn1∕3Co1∕3)O2)), a negative one (Li), and a solid electrolyte, which is the critical component, composed of inorganic compound and/or solid polymer electrolyte (SPE) [1]. On the one hand, SPE have the advantage of an easy shaping with the technique already used in the manufacture of batteries and their flexibility allows

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18

Holland, Thomas J., Gregory James Offer, and Monica Marinescu. "Benchmarking Degradation Mode Analysis Methods Using a Physics-Based Degradation Model with Coupled Degradation Mechanisms." ECS Meeting Abstracts MA2025-01, no. 1 (2025): 92. https://doi.org/10.1149/ma2025-01192mtgabs.

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Diagnosing battery degradation is critical for understanding the state of a cell in operation to predict remaining useful life. Degradation Mode Analysis (DMA) is increasing in popularity as a tool for diagnosing the state-of-health (SOH) of a cell in more detail than capacity-based methods. By attributing degradation to loss of lithium inventory (LLI) or loss of active material (LAM) on each electrode, the gap between the diagnosed state and the underlying degradation mechanism is reduced. DMA relies on a fitting procedure, which makes the potential sources of error numerous. As a thermodynam

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19

"Final Report of the Safety Assessment of Alcohol Denat., Including SD Alcohol 3-A, SD Alcohol 30, SD Alcohol 39, SD Alcohol 39-B, SD Alcohol 39-C, SD Alcohol 40, SD Alcohol 40-B, and SD Alcohol 40-C, and the Denaturants, Quassin, Brucine Sulfate/Brucine, and Denatonium Benzoate1." International Journal of Toxicology 27, no. 1_suppl (2008): 1–43. http://dx.doi.org/10.1080/10915810802032388.

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Alcohol Denat. is the generic term used by the cosmetics industry to describe denatured alcohol. Alcohol Denat. and various specially denatured (SD) alcohols are used as cosmetic ingredients in a wide variety of products. Many denaturants have been previously considered, on an individual basis, as cosmetic ingredients by the Cosmetic Ingredient Review (CIR) Expert Panel, whereas others, including Brucine and Brucine Sulfate, Denatonium Benzoate, and Quassin, have not previously been evaluated. Quassin is a bitter alkaloid obtained from the wood of Quassia amara. Quassin has been used as an ins

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20

Goncalves, Gabriel Luiz Padoan, Lenadro Do Prado Ribeiro, and José Djair Vendramim. "TOXICITIES OF Annona DERIVATIVES AND SEMI-PURIFIED FRACTIONS AGAINST Zabrotes subfasciatus." Tropical and Subtropical Agroecosystems 24, no. 3 (2021). http://dx.doi.org/10.56369/tsaes.3184.

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<p><strong>Background. </strong>The Annonaceae botanical family is a promising source of new insecticidal molecules that can be used to protect stored beans against Bruchinae beetles due to its variety of bioactive compounds such as alkaloids and acetogenins. Bruchinae beetles are major pests of stored beans in the world. These beetles feed on stored beans and they promote high levels of damages. <strong>Objective. </strong>The present study assessed the lethal and sublethal effects of crude ethanolic extracts prepared from different parts (leaves, branches and se

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21

Bernardes, Wagner Antônio, Edson Luiz Lopes Baldin, Mariane Coelho, Antônio Eduardo Miller Crotti, Wilson Roberto Cunha, and Leandro Prado Ribeiro. "MANAGEMENT OF THE MEXICAN BEAN WEEVIL BY ADDING AROMATIC PLANT DERIVATIVES IN TWO DRY FORMULATIONS." Tropical and Subtropical Agroecosystems 23, no. 2 (2020). http://dx.doi.org/10.56369/tsaes.2857.

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<p><strong>Background.</strong><em> Zabrotes subfasciatus</em> (Boh., 1833) (Coleoptera: Chrysomelidae: Bruchinae), is considered one of the most important pest of stored beans. <strong>Objective. </strong>This study reports the possible toxicity and repellence of powders prepared from eight plant species against the Mexican bean weevil in two formulations (dry powder and sachets). <strong>Methodology.</strong> A 10 <sub>˟</sub> 2 factorial design (10 species <sub>˟</sub> 2 formulations) with 8 repetitions in a compl

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22

Sapolsky, Robert M., Lewis C. Krey, and Bruce S. McEwen. "The Neuroendocrinology of Stress and Aging: The Glucocorticoid Cascade Hypothesis." Science of Aging Knowledge Environment 2002, no. 38 (2002). http://dx.doi.org/10.1126/sageke.2002.38.cp21.

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Over the past 5 yr, we have examined some of the sharpest edges of the pathology of aging. We have studied the capacity of aged organisms to respond appropriately to stress and the capacity of stress to cumulatively damage aging tissue. The idea of a relationship between stress and aging has permeated the gerontology literature in two forms. First, senescence has been thought of as a time of decreased adaptiveness to stress. This idea has been supported frequently, as many aged physiological systems function normally under basal conditions, yet do not adequately respond to a challenge. For exa

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23

Dawson, Andrew. "Reality to Dream: Western Pop in Eastern Avant-Garde (Re-)Presentations of Socialism's End – the Case of Laibach." M/C Journal 21, no. 5 (2018). http://dx.doi.org/10.5204/mcj.1478.

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Introduction: Socialism – from Eternal Reality to Passing DreamThe Year of Revolutions in 1989 presaged the end of the Cold War. For many people, it must have felt like the end of the Twentieth Century, and the 1990s a period of waiting for the Millennium. However, the 1990s was, in fact, a period of profound transformation in the post-Socialist world.In early representations of Socialism’s end, a dominant narrative was that of collapse. Dramatic events, such as the dismantling of the Berlin Wall in Germany enabled representation of the end as an unexpected moment. Senses of unexpectedness res

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