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1
Gomes, Véronique. "Structure et propriétés interactives de l'antigène variable de Trypanosoma brucei brucel." Grenoble 2 : ANRT, 1988. http://catalogue.bnf.fr/ark:/12148/cb37613990k.
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Abarca, Cordero Julio César. "Jerome Seymour Bruner (1915-2016)." Pontificia Universidad Católica del Perú, 2017. http://repositorio.pucp.edu.pe/index/handle/123456789/102410.
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Haji, Wahsalfelah Siti Norkhalbi. "Traditional woven textiles : tradition and identity construction in the 'new state' of Brunei Darussalam." University of Western Australia. Anthropology and Sociology Discipline Group, 2006. http://theses.library.uwa.edu.au/adt-WU2006.0013.
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Since its independence in 1984, politicians and nationalists in Brunei Darussalam have appealed to traditions in their efforts to create a national identity based on Brunei Darussalam’s national philosophy, `Malay Islamic Monarchy’. Weaving is one of the traditions related to Brunei traditional culture, thus traditional textile is used to construct national identity. This study focuses on the role played by powerful institutions in the creation of new tradition in order to foster national awareness in the `new state’ of Brunei Darussalam and I examine how traditional textiles are incorporated into the project of nation building. In Bruneian society, traditional woven cloths have multiple roles whose meanings vary according to the situation in which the traditional cloth is utilized. This research explores the significance of traditional textiles in Brunei Darussalam, focusing on the consumption of locally woven textiles in its traditions and the relationships to the expression and construction of identity. Since Islam came to Brunei Darussalam, it has become one of the predominant markers of identity of the Malays. This study analyse the influence of Islam in the production and consumption of traditional textile in Brunei Darussalam. The continuity of the production and consumption of traditional woven textile in Brunei Darussalam is very much dependent on its significant in the traditions of Brunei society as a whole. In order to prove this, this study focuses its investigation upon the production and uses of traditional textiles in the social customs of Malay society in Brunei Darussalam. Traditional woven textiles are employed to construct social identity in the reproduction of distinction. Traditional textiles are also offered to signify privilege and power. I examine how traditional textile is being used to distinguish social status and political prominence, denote offices, and display wealth and prestige.
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Budde, Heike. "Antioxidant defense in Trypanosoma brucei brucei." [S.l.] : [s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=968912192.
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Jackman, Simon Andrew. "Dihydrolipoamide dehydrogenase in Trypanosoma brucei brucei." Thesis, University of Bath, 1991. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.760619.
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Shah, Madad Ali. "Brunel DGPS system for blind navigation." Thesis, Brunel University, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.392073.
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Razak, Abdul. "Brunei Bay northwest Borneo : depositional system." Thesis, University of Aberdeen, 2001. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=206630.
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Brunei Bay in Northwest Borneo is a semi circular marine embayment formed during the last marine transgression. It represent a complex tropical depositional system in a micro-mesotidal setting in which the following elements can be recognised - an elongate bird's foot delta with abandoned lobes, drowned river valleys, cuspate delta and classic tidal estuary - all within 50 krn of each other. Understanding the control on the morphology of the sand bodies produced within the overall depositional system is of great importance because it is believed that many of the subsurface hydrocarbon reservoirs in Northwest Borneo were deposited in a depositional setting similar to that of modern-day Brunei Bay. This study therefore has major implications for defining the architecture and connectivity of subsurface reservoirs. A detailed bathymetry survey of western Brunei Bay has been undertaken which acted as guide for subsequent hydrodynamic measurements and coring programme. The results of this study indicate that the localised depositional setting plays a key role in understanding sandbody geometry because the orientation of sandbodies and facies distribution varies considerably. Tidal processes playa significant role in shaping the sediment distribution and facies characteristic of the area although locally wave processes can play a significant role. Tidal sandbodies parallel to the direction of drowned rivers, form a large arcuate-shaped complex less constrained by the structural trend. This study suggests that within Brunei Bay, morphology and tidal range is not a good indicator of the dominant process. Mud, exceptionally rich in plant debris derived from the mangrove swamps, accumulates in low energy environments peripheral to the distributary channel, reinterpretation of many coal horizons in the Miocene of the region which have largely been ascribed to a raised setting. This study indicates that the present day Brunei Bay is an excellent analog for the tidally influenced succession of Northwest Borneo. Conversely, it also indicates that the Baram Delta located approximately 100 krn west of Brunei Bay is not a suitable analog for the interpreted wave influenced Miocene succession of Northwest Borneo.
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Gruer, Emmanuel. "Les tumeurs brunes osseuses de l'hyperparathyroïdie." Dijon, 1996. http://www.theses.fr/1996DIJOM026.
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"Les méthodes de diagnostic actuelles permettent dans la majorité des cas le diagnostic d'hyperparathyroïdie avant la survenue de complications graves, notamment rénales et osseuses, et parfois à un stade asymptomatique. Le principal examen complémentaire utilisé en cas de suspicion d'une hyperparathyroïdie est le dosage immunologique de la PTH intacte. Les techniques de localisation préparatoire ne sont le plus souvent pas indispensables, la cervicotomie exploratrice permettant à la fois le dépistage des lésions parathyroïdiennes et le traitement de la maladie de façon efficace. Certains auteurs préconisent dans ces cas particuliers un traitement médical conservateur. Les tumeurs brunes, dont nous rapportons une observation, sont une des manifestations osseuses pseudotumorales de l'hyperparathyroïdie. Avec la disparition des formes évoluées de cette maladie, ces tumeurs sont devenues plus rares. Il est cependant important de les inclure dans le diagnostic différentiel de lésions osseuses lytiques du squelette [. . . ]. " [Source : 4e de couv. ]
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Marie-Pierre, Hasne. "Amino acid transporters in Trypanosoma brucei brucei." Thesis, University of Glasgow, 2001. http://theses.gla.ac.uk/6544/.
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Two approaches have been used to investigate the nature of amino acid transport in T. brucei. The first approach involved studying the uptake of radiolabelled amino acids by the parasite, the second approach involved the identification, cloning and expression in a heterologous system of a gene encoding for a putative amino acid transporter. The biochemical approach revealed that methionine uptake was of relatively high affinity in procyclic and bloodstream forms and dependent on a proton motive force. The recognition motif of this transporter encompasses the amino acid core as well as the two carbon atoms of the side chain. The anionic amino acids, aspartate and glutamate, were shown to be taken up poorly or not at all by specific transport mechanisms in the two forms of the parasite. The aromatic amino acids, phenylalanine, tyrosine and tryptophan, are taken up via several different routes indicating the importance of these amino acids for the parasite. The cloning and expression of TbAATP1 in Xenopus oocytes revealed that this gene encodes for an amino acid transporter that is able to transport tyrosine, glutamine and glutamate. TbAATP1 is the first member of what was subsequently shown to be a family of genes, encompassing at least twelve members present on three different chromosomes (IV, VI, VIII). On chromosome IV six of these genes appeared to form a cluster.
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Pengiran, Haji Osman/Othman Pengiran Karim. "The evidence of oriental ceramic and earthenware distributions in Brunei Darussalam as an aid in understanding protohistoric Brunei." Thesis, University of Southampton, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.242692.
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Galland, Franck. "Planètes et naines brunes autour d'étoiles chaudes." Phd thesis, Université Joseph Fourier (Grenoble), 2006. http://tel.archives-ouvertes.fr/tel-00108982.
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Dans le cadre de la recherche de planètes extrasolaires et de naines brunes, cette thèse innove en se focalisant sur le cas d'étoiles naines de type spectral A et F, plus chaudes que le Soleil. J'ai développé une nouvelle méthode de mesure de vitesses radiales, que j'ai testée puis appliquée lors de recherches systématiques avec les spectrographes ELODIE et HARPS, qui a abouti pour le moment à la découverte de deux planètes et d'une naine brune, et de nombreux candidats. J'ai aussi développé des diagnostics de la présence de pulsations ou d'activité affectant la surface stellaire et les vitesses radiales mesurées. J'ai aussi conduit cette recherche en imagerie directe à haute résolution angulaire, en utilisant les instruments PUEO et NACO. Les compagnons candidats détectés doivent être confirmés. Cette recherche permettra d'établir les caractéristiques des planètes et naines brunes autour d'étoiles A et F, et l'influence de la masse de l'étoile-hôte sur les processus de formation.
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Pg, Haji Hassan Dk Noor Hasharina Binti. "Everyday finances and consumption in Brunei Darussalam." Thesis, University of Southampton, 2010. https://eprints.soton.ac.uk/192863/.
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After the financial global crisis in 2008, there has been a growing interest in studying financialisation in economic geography mainly in Anglo-American societies. Most attempts in understanding finance in Geography focus on macro level finance culture i.e. examining financial structures and institutions. With financial iberalisation, financial institutions play a significant role in influencing the financial markets in Anglo-America while government interference has been declining. Social scientists such as Langley (2008) and Lee et al. (2009) identified a dearth of literature in economic geography that focuses on everyday personal finances of consumers and relate consumers’ borrowing culture to their consumption patterns which are shaped by social intermediaries including governments, family and traditions. This thesis fills this gap in contemporary areas in economic geography. The aim of the thesis is to examine the development of personal finances and consumption in Brunei Darussalam. Brunei makes a relevant case study due to its distinctive evolving personal finance and consumption culture where the government plays a significant role through the monitoring and regulating of financial institutions. Regulating Brunei’s financial structure was a pro-active action taken by the government to address problems of Bruneians’ dependency on borrowing to consume rather than as a reaction to the global financial crisis. Moreover, this study shows how individual choices and actions as well as traditional cultural intermediaries (du Gay et al., 1997) particularly the family and traditions shape Bruneians’ financial access and consumption culture. My thesis demonstrates that financialisation and consumption culture are not homogenised across different geographies, thus stresses the importance of acknowledging and need to consider social and cultural practices of consumers and governments in order to understand the financial and consumption culture and development of different societies.By employing mixed methods in particular qualitative research methods, this thesis also presents empirical evidence of the transformation in financial culture and identifies functions and motivators of consumption that affect consumers’ everyday finances in Brunei which are different from other geographies including Anglo- America
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Kassim, Mona Yati Mohd. "Tourism in Brunei Darussalam : content and context." Thesis, Loughborough University, 2003. https://dspace.lboro.ac.uk/2134/34408.
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The purpose of this research was to analyse the content and context of tourism stakeholder management in Negara Brunei Darussalam and to investigate stakeholder views on tourism management, planning and development. The author attempted to identify the web of stakeholders as perceived by the main key groups of players in the tourism industry in the months leading up to the sultanate's first ever 'Visit Brunei Year 2001'. In addition, she attempted to investigate the underlying causes of ineffective tourism management in Negara Brunei Darussalam, which operates under a strict Malay Muslim Monarchy ('Melayu Islam Beraja' or'MIB') system of governance and national philosophy. Many hold the view that developing the tourism industry in Negara Brunei Darussalam is a necessary stepping-stone towards diversification from its dependence on oil and gas. However, very little effort has been made to educate the general community on its benefits and disadvantages. In addition, only a very select group of people are directly involved in its planning and development leading to conflict in the community. Little has been said about real community support of tourism development and on the impact it may have on its stakeholders. The present study has attempted to do this. Problems in tourism management, planning and development are expected to arise because of Negara Brunei Darussalam's inexperience in this field, lack of coordination and planning between government and private sectors; and, perhaps due to conflict between its MIB philosophy and the perceived negative nature of the tourism industry. Research was conducted in several stages from November 1999 to February 2001. Data collection from the fieldwork was elicited through questionnaires administered by four trained interviewers in all four districts in Negara Brunei Darussalam and through in-depth interviews with selected tourism stakeholders by the author. The author observed that key players of tourism were relatively unaware of the concept of community participation in tourism development and planning, as well as the identity of a wider range of tourism stakeholders. The community at large does support tourism development and planning and expectations for accrual of tourism revenue and benefits are high. Many in the private sector have voiced the view that the government should do more to give this industry a boost. Similarly, the governmental body believes that a pro-active private sector is needed for sustainability of this industry. An alternative model to western stakeholder management is proposed that is applicable to this small Muslim sultanate.
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Salleh, Norzamni. "Sharing spatial data in Brunei government departments." Thesis, University of Salford, 2010. http://usir.salford.ac.uk/26890/.
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Spatial data are items of information related to a location on earth. The early forms of spatial data included maps, survey plans, coastal charts and geodetic triangulation. With the advancement of technology, this spatial data have increased its importance. Decision makers from many disciplines tend to rely on up-to-date relevant, wider and accessible spatial data as an essential input in supporting their operational and strategic decisions. The demand to access multi-organisations spatial data continue to increase and this has pushed organisation to share their spatial data as rarely all these data sets reside within one organisation. However, there are persistent challenges that limit the utilization of available spatial data across organizations. The existence of these challenges is a global phenomenon and Brunei, a small country in south East Asia is no exception. The main purpose of this research is to identify factors that impede spatial data sharing within government departments in Brunei and use the findings to develop a framework for sharing spatial data within the government departments. The proposed framework took the innovative approach of combining both technical and non- technical factors, which have not been currently addressed. This research adopted multiple holistic case studies in 3 selected government departments in Brunei. A comprehensive literature review of relevant topics helped in designing a preliminary guideline for research in spatial data sharing. This guideline is used as a basis for data collection and at the same time refined by the case studies. Both content analysis and cognitive mapping techniques were applied to help in customizing the framework for sharing spatial data in Brunei, the ultimate product of this research. The framework comprises of two different components, which include the contextual component and the collaborative process component. Under the collaborative process component, there were 5 key elements that are crucial in spatial data sharing. This includes leadership, formal agreement, IT structure, monitoring and review and security. The framework was not empirically validated due to the immaturity of spatial data sharing in Brunei, unable the framework to be validated empirically. At such, opinions from the experts on the appropriateness of the framework were elicited as an initial validation. Efforts were also made by assessing the impact of each key element to the past data sharing projects in Brunei. The research concluded that the proposed framework offers a viable and effective formal mechanism for data sharing and coordination of spatial activities within government departments in Brunei. It is envisaged that with minor amendments to the policy aspects, the framework is expandable for application to private sectors.
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Haji, Mohd Daud Sabrina. "An examination of the challenges to implementing integrated land-use and transport (LUT) strategies to reduce transport emissions : a case study of Brunei-Muara and its sub-districts and their associated villages." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648324.
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Lionneton, Eric. "Elaboration d'une carte génétique de la moutarde brune (Brassica juncea L. ) et marquage moléculaire de caractères liés à la qualité de la graine." Dijon, 2002. http://www.theses.fr/2002DIJOS023.
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Mohamad, Hanapi. "Promoting creativity in early childhood education in Brunei." University of Western Australia. Graduate School of Education, 2006. http://theses.library.uwa.edu.au/adt-WU2006.0130.
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[Truncated abstract] The overall aim of this study was to examine Bruneian preschool teachers’ conceptions about creativity (including factors related to creativity), their beliefs on how to promote children’s creativity in the classroom, how their beliefs may influence their actual practice and whether their practices are consistent with the requirements of the Brunei National Curriculum. It will also try to identify any factors that constrain or influence teachers’ practice. The research employed a grounded theory approach involving semi-structured interviews and classroom observations of preschool teachers. The findings of this study indicate that the teachers primarily conceptualise creativity as something mainly but not exclusively to do with art work . . . Teachers’ actual practice mainly consists of teacher control, enforcement of obedience, rote learning, teacher directed and teacher chosen activities and heavy emphasis on whole-class teaching. Other mediating constraints on their promotion of creativity included: pressure from Primary 1 teachers, parents and the officials in Ministry of Educations to complete and adhere to the National Curriculum; teachers’ own pedagogical limitations; large class size; lack of adult help and the presence of special children in the classroom; lack of resources and pressure from other non-teaching commitments. The implication of the findings are that further research needs to be conducted into Brunei’s preschool teacher training programmes, to identify contradictory messages about the value of creativity and to find a more culturally appropriate way of promoting children’s creativity through the curriculum.
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Delfosse, Xavier. "Naines brunes et étoiles de très faible masse." Phd thesis, Université Joseph Fourier (Grenoble), 1997. http://tel.archives-ouvertes.fr/tel-00686419.
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Bien qu'elles dominent en nombre la population stellaire de la Galaxie, les étoiles de très faible masse et les naines brunes sont longtemps restées difficiles (voir impossibles) à observer, à cause de leur faible luminosité. Les progrès récents des techniques instrumentales (et en particulier des détecteurs infrarouges) permettent maintenant de s'y intéresser et de commencer à répondre à de nombreuses questions. Parmi celles-ci, deux sont particulièrement importantes et nécessitent une bonne détermination de la fonction de masse (nombre d'objets par intervalle de masse): l'influence de cette population sur la dynamique Galactique, et le comportement de la fonction initiale de masse à l'approche du régime naine brune. Ces objets permettent d'autre part des tests sévères de notre compréhension de la physique des objets dégénérés, et des atmosphères denses et froides dominées par les opacités moléculaires. Dans cette thèse, j'ai d'abord déterminé la fonction de luminosité (nombre d'objets par intervalle de luminosité) jusqu'à la limite étoiles-naines brunes, ce qui est la première étape de la construction de la fonction de masse. Pour cela j'ai utilisé le relevé DENIS (a Deep Near Infrared Southern sky survey qui est parfaitement adapté à la détection de ces objets, et étudié les biais importants de la fonction de luminosité introduits par le bruit. Au cours de ces travaux la première naine brune confirmée du champ a été découverte et une étude spectroscopique des naines brunes froides a été entreprise. Pour passer de cette fonction de luminosité à la fonction de masse, il est ensuite necessaire, 1- de corriger le biais important de la fonction de luminosité causé par les étoiles binaires, et 2- de disposer d'une bonne relation masse-luminosité. Ces deux étapes de la détermination de la fonction de masse passent par une étude de binarité. Une recherche systématique de binaires spectroscopiques a donc été entreprise dans cette thèse. Elle a révélé que le voisinage solaire (à moins de 9 pc) reste mal connu, et qu'un nombre important de compagnons y reste à découvrir (11 ont été mis en évidence ici). La distance des systèmes doubles non identifiés est également sous-estimée. Enfin, l'étude de la rotation des naines M du champ a été un sous-produit important du programme de recherche de binaires. Elle a clairement montré que l'activité chromosphérique de ces objets, depuis longtemps connue, est bien due à leur rotation. L'allongement du temps de freinage aux type spectraux les plus tardifs est ainsi demontrée jusqu'à des âges beaucoup plus grands, et jusqu'à des masses où les étoiles sont entièrement convectives.
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Delorme, Philippe. "Les naines brunes dans les relevés grand champ." Phd thesis, Université Joseph Fourier (Grenoble), 2008. http://tel.archives-ouvertes.fr/tel-00351010.
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Mon travail de recherche au cours de ces trois années de thèse sous la direction de Thierry Forveille et de Xavier Delfosse au laboratoire d'astrophysique de Grenoble a été consacré à la recherche de naines brunes dans un relevé grand champ de nouvelle génération que nous avons appelé le Canada-France Brown Dwarf Survey -CFBDS-. La thématique de ma thèse est centrée sur l'étude des naines brunes froides et la constitution d'un grand échantillon de naines brunes, comme base pour une analyse statistique photométrique et spectroscopique. J'étais chargé en premier lieu de la mise au point du pipeline d'analyse et de sélection des candidats au sein de la collaboration internationale dédiée à la recherche de naines brunes et de quasars à grand décalage vers le rouge. En tant que seul membre de la collaboration à travailler à plein temps sur le projet, j'ai toutefois été amené à m'impliquer fortement dans presque toutes les facettes du projet. En parallèle du travail scientique que je présente dans ce manuscript, j'ai consacré une part importante de ma thèse à la coordination du travail entre les différentes personnes impliquées dans le CFBDS de par le monde. Dans le chapitre 1, je fais un récapitulatif rapide de l'ensemble des avancées scientiques dans le domaine des naines brunes avant la présente thèse. Le chapitre 2 présente le Canada- France Brown Dwarf Survey, qui fournit les données au coeur de mon travail, ainsi que notre stratégie d'analyse. Le chapitre 3 détaille le pipeline que j'ai mis en place pour identier au mieux les quelques centaines d'astres qui nous intéressent parmi les dizaines de millions de sources que comptent les images du CFBDS. Ce chapitre met aussi en évidence les performances de la fonctionnalité d'analyse d'image par ajustement de fonction d'étalement du point -PSF- que j'ai adjointe au logiciel Source Extractor. Les candidats ainsi identiés sur la base de leur photométrie sont présentés dans le chapitre 4. Dans ce chapitre je décris mes méthodes d'estimation des biais statistiques du CFBDS, ainsi que la fonction de luminosité des naines brunes du champ que nous en avons extraite. Enn le chapitre 5 donne une revue détaillée des informations contenues dans le spectre des naines brunes. J'y présente ensuite nos observations spectroscopiques ainsi que les résultats associés, notamment la découverte d'absorption par l'ammoniac dans le spectre de la naine brune la plus froide publiée à ce jour, CFBDS0059, ainsi que la découverte de la première naine T sous-métallique.
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Levy, Ruth. "Community structure of ants in Brunei rain forest." Thesis, University of Oxford, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.240586.
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Ebil, Syazana. "Assessment of demersal fishery resources in Brunei Darussalam." Thesis, University of Warwick, 2013. http://wrap.warwick.ac.uk/57704/.
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A problem commonly encountered in stock assessments of tropical marine resources in developing countries is data paucity, which invariably results from the lack of both human and economic capacity within the government to implement and maintain programmes for data collection and analysis. With special reference to the demersal fishery of Brunei Darussalam, this thesis examines approaches for extracting useful information from data-poor fisheries to assess the state of resources and inform fishery management actions. By using official fishery statistics, augmented by local ecological knowledge (LEK) obtained from fishers engaged in either the large-scale (LS) or small-scale (SS) fisheries in Brunei, changes in demersal fishery resources over the years were assessed. The sustainability of Brunei’s demersal capture fishery was evaluated in the face of its ongoing development and climate change. Using trophodynamic indicators such as mean trophic level (MTL), Fishing-in- Balance (FiB), trophic spectra (TS) and community structure analyses, LS fishery catches of Brunei between 2000 and 2009 revealed a deteriorating state of the coastal demersal ecosystem. Closer examination of the abundance of overall demersal finfish stocks, using the Catch-Per-Unit-Effort (CPUE) index – standardised for other factors not related to abundance – indicated a declining trend, even when total catches remained stationary, although trends in abundance of the different demersal fish families varied. This rapid significant change in recent years is further supported by fishers’ LEK on relative abundance of Brunei marine resources. The study on LEK has also revealed the ‘shifting baseline syndrome’ (SBS) among currently active fishers and their exploited populations, a phenomenon not previously reported for Brunei fisheries. Findings from the study are synthesised with other information, where a number of key issues and policy options are discussed, and recommendations for the management of the fishery are made. This thesis demonstrates that researchers in data-poor fisheries can utilise different assessment tools, given the resources at their disposal, to assist in the management of marine resources.
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Haji, Md Sum Hisham. "Educational dependency : a case study on Brunei Darussalam." Thesis, University of Reading, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.335887.
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Haji, Awang Radzuan Mohammad Sofian. "Evolving Brunei Darussalam's economy towards technology-based industries." Thesis, University of Sussex, 2016. http://sro.sussex.ac.uk/id/eprint/65634/.
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Technology-Based Industries continue to be at the forefront of a nation's sustainable economic development. These account for the largest share of employment, business activity and labour income in most primary sectors. Technology-Based Industries contribute to multi-lateral development of a nation's economy through innovation, new technologies and use of new knowledge. The government of Brunei Darussalam sought in the past decade to diversify the economy with limited success. Oil and gas and government spending still account for most of Brunei's economic activity. The small size of the domestic market discourages foreign direct investment in Brunei Darussalam. Brunei's government encourages foreign investment especially when it involves emerging new technologies and technology transfers. The research question is: how to transfer new technologies into Brunei Darussalam industry and to quantify the impact of these Technology-Based Industries; can a resource based-economy offer a solution to tackle the difficulties in industrial advancement that Brunei Darussalam is currently struggling with. This research aims to study factors for the successful transfer of technology-based industries and identify the key issues in technology transfers that significantly affect the rate of technological integration and evaluate the concept of technology transfers and its contribution to the sustainable economic development of a small state economy. It adopts multiple techniques both inductive and deductive approaches through SWOT-analysis and case studies to explore and later analyze the importance of the visionary drive underlying the technology-based industrial strategy that contributes to policy improvement, via awareness of alternatives and discovery of latent policy constraints and opportunities from investigation of others' experience. The bottom line of this research is to provide the basis for government policies on how the technology transfer can be achieved in the Brunei Darussalam industrial context.
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Zhao, Lee Zhuo. "Brunet-Derrida particle systems and selectively accessible paths." Thesis, University of Cambridge, 2014. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708315.
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Sabtu, K. "Evaluation of diabetic retinopathy screening in Brunei Darussalam." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2015. http://researchonline.lshtm.ac.uk/2391561/.
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In recognition of the increasing prevalence of diabetes in Brunei, and the expected increase in diabetic retinopathy (DR), primary health centre based DR screening was introduced in 2006 for seven health centres in the Brunei-Muara district. The Brunei National Prevention of Blindness from Diabetic Retinopathy is a policy document calling for DR screening to be made systematic at a national level. However, the effectiveness of the model in practice was not evaluated and the DR screening programme was launched without a baseline survey and situation assessment. Consequently, the responsiveness of the health system to embed a systematic approach to DR screening has faced many constraints and was slow to evolve. This study has provided evidence to support the implementation of the policy document and baseline information on the gaps and challenges within the key service provision stages for DR screening and treatment. The overall objective of this thesis was to evaluate the DR screening model in the Brunei-Muara District. Results from this study suggest that the DR screening model in Brunei-Muara is partially systematic. The main findings showed that key processes are in place at different stages of DR screening and treatment and that sufficient resources have been allocated to detect sight threatening diabetic retinopathy (STDR) at primary health centres (PHCs) and to treat STDR at the national eye centre (NEC). This was supported by the good DR annual screening uptake rates (77%) and low DR prevalence rates (5.8%) reported in this study. However, the lack of monitoring of both the implementation processes and screening effectiveness was viewed as key limitations in the programme. This was evident through process gaps observed throughout the DR screening and treatment pathway including the identification of patients for screening at PHCs, GP to DR referral process, referral for treatment processes to NEC and disease registers that were not integrated and lacked accuracy. This was also backed by evidence that DR screening coverage rates were low (56%) across all health centres. Based on a generic framework to analyse development of DR screening programmes used in this study, the existing screening model could be enhanced by improving screening coverage rates, universal access to DR treatment, trained and certified workforce, implementation of a call and recall system and systematic digital photography screening system. However, further studies are required before these recommendations could be implemented.
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Brune, André [Verfasser]. "Elektrisch erregte Synchronmaschinen als Fahrantriebe / André Brune." Garbsen : TEWISS - Technik und Wissen GmbH, 2019. http://d-nb.info/1176166190/34.
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Le, Bail Aude. "Morphogenèse précoce de l'algue brune Ectocarpus siliculosus." Paris 6, 2009. http://www.theses.fr/2009PA066477.
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Cette thèse initie l’étude de la morphogenèse de l’algue brune modèle Ectocarpus siliculosus, qui est formée d’un filament primaire unisérié comportant des embranchements. Dans un premier temps, l’étude du patron de développement précoce a mis en évidence une croissance apicale des filaments suivie d’une différenciation cellulaire centripète aboutissant à deux types de cellules. Ces données ont ensuite été utilisées pour modéliser le développement d’E. Siliculosus grâce à une approche par simulation informatique, révélant qu’aux stades très précoces, la connaissance par chaque cellule de l’identité des cellules voisines est suffisante pour créer des filaments identiques à ceux observés en culture. Cette hypothèse est appuyée par l’étude du mutant de morphogenèse étoile, qui possède une capacité de prolifération cellulaire accrue et met en évidence l’importance de protéines transmembranaires à domaine Notch dans la mise en place du patron de développement. En parallèle, la phytohormone auxine a été détectée dans les filaments avec une concentration maximale aux apices, et semble jouer un rôle dans la morphogenèse de l’algue en procurant aux cellules une information de position globale permettant la mise en place du patron d’embranchements. De plus, l’analyse du génome a permis de montrer qu’E. Siliculosus possède la machinerie enzymatique nécessaire à la synthèse de l’acide indole-3-acétique. La morphogenèse d’E. Siliculosus pourrait ainsi requérir l’intervention de deux types de mécanismes, une signalisation paracrine faisant intervenir des protéines transmembranaires à domaine Notch, et une signalisation à distance par l’intermédiaire d’un gradient d’auxine.
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Matumba, Tshifhiwa Given. "Genetics and thermal biology of littorinid snails of the genera Afrolittorina, Echinolittorina and Littoraria (Gastropoda: Littorinidae) from temperate, subtropical and tropical regions." Thesis, Rhodes University, 2013. http://hdl.handle.net/10962/d1001953.
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With the anticipated effects of climate change due to global warming, there is concern over how animals, especially ectotherms, will respond to or tolerate extreme and fluctuating environmental temperature stress. Littorinid snails are intertidal ectotherms that live high on the shore where they experience both extreme and variable conditions of temperature and desiccation stress, and are believed to live close to their tolerance limits. This study investigated the thermal biology of littorinid snails of the genera Afrolittorina, Echinolittorina and Littoraria from temperate, subtropical and tropical regions in South Africa and Brunei Darussalam using thermal tolerance, heart function, and proteome approaches. The effects of conditions, such as rate of change in temperature, acclimation, heat shock, season and starvation were also tested. In addition, the evolutionary relationships and genetic diversity between and within the South African Afrolittorina spp. were investigated using mitochondrial and nuclear markers. Genetic results confirmed that these are two distinct species, with the brown to black A. knysnaensis predominant in the cool-temperate region of South Africa and the pale blue-grey A. africana in the subtropical region. There was low genetic variation and differentiation within each species, suggesting high gene flow among populations as a result of the effects of ocean currents on the dispersal of their planktotrophic larvae. Tests using exposure to high temperatures revealed differences in the thermal tolerances, heart performance and protein profiles of species from different latitudes, regions and zones on the shore. Thermal tolerance conformed to expectations, with clear, statistically significant trends from high tolerance in subtropical species to lower tolerance in temperate species. However, for Afrolittorina spp., there were no significant differences in the thermal tolerances of conspecifics from different regions, though there was a significant difference in thermal tolerance between juveniles and adults. Overall, adults of all species showed higher thermal tolerances than juveniles. Although lethal temperatures for these species were higher in summer than winter, laboratory acclimation had no effect on heat coma temperatures. All species showed some regulation of heart rate, with a degree of independence of heart rate from temperature across mid-range temperatures. The tropical species showed quick induction and good regulation of heart rate followed by the subtropical and temperate species, which displayed mixed responses including regulation, partial regulation and lack of regulation. Overall, tropical Echinolittorina spp. showed good regulation, while the subtropical E. natalensis and Littoraria glabrata exhibited a mixture of partial regulation and regulation. The subtropical/temperate Afrolittorina spp. showed high individual variability, some animals exhibiting regulation, while others did not. These effects seem to be largely phylogenetically determined as there were no differences in the heart rate responses of Afrolittorina spp. from different regions. The temperatures at which heart rate became independent of temperature (thermoneutral zone) were within the range experienced under natural conditions. In addition, there were differences in Arrhenius breakpoint and endpoint temperatures, showing a trend from higher in tropical animals to lower for temperate animals. Conditions such as acclimation, heat shock and starvation had little or no effect on heart performance. However, a slow increase in temperature induced good regulation of heart rate with noticeable shifts of breakpoints and endpoints for Afrolittorina spp. Lastly, there were differences in the proteome responses between and within Afrolittorina spp. as a function of species, size and treatment. Although both large and small A. knysnaensis had a greater number of protein spots in their proteome than A. africana (though the difference was not significant), the later showed significantly higher differential expression of certain proteins following heat stress. In addition, juveniles of both species displayed greater numbers of protein spots in their proteome than adults. The results indicate a difference in the physiological and biochemical responses (i.e. adaptations) of these snails to temperature, and this seems to relate to differences in biogeography, phylogeny, species identity and ecology. The ability to regulate heart rate is phylogenetically determined, while thresholds and lethal limits correspond to biogeography and species ecology. The proteome seems to correspond to species ecology. The results also indicate that these littorinids can tolerate high temperature stress and in this respect they are well suited to life in the intertidal zones or habitats where temperature and other stresses or conditions are extreme and can change abruptly. However, the limited ability of these snails to acclimate to different temperatures suggests that they are already living close to their tolerance limits with small safety margins or narrow thermal windows and so may be vulnerable to small rises in substratum temperature and/or solar radiation.
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Ebikeme, Charles E. "Amino acid transporters and amino acid metabolism in trypanosoma brucei brucei." Connect to e-thesis, 2007. http://theses.gla.ac.uk/55/.
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Thesis (Ph.D.) - University of Glasgow, 2007.Ph.D. thesis submitted to the Division of Infection and Immunity, Institute of Biomedical and Life Sciences, University of Glasgow, 2007. Includes bibliographical references.
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Ebikeme, Charles E. "Amino acid transporters & amino acid metabolism in Trypanosoma brucei brucei." Thesis, University of Glasgow, 2007. http://theses.gla.ac.uk/55/.
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The development of new drugs against Human African Trypanosomiasis is much needed due to toxicity, efficacy and availability problems with current drug treatments for this resurgent parasitic disease. Delivery of drugs into cells is an important determinant of therapeutic efficacy of drugs. An effective means of selective drug delivery is to use plasma membrane transport systems to mediate the entry of drugs into the cell. Some amino acid transporters fulfil the criteria needed for successful exploitation of nutrient transport systems for drug delivery. The Trypanosoma brucei genomic database was screened to identify the full gene repertoire of amino acid transporters. From this, candidate genes were selected and functional genetic approaches were employed to characterise candidate amino acid transporter genes. Further characterisation of TbAATP1, a RNAi cell line shown to be a transporter of small neutral amino acids (serine, glycine, cysteine, asparagine and alanine), showed a role in threonine uptake. Amino acid analogues were tested for trypanocidal activity. Of the 96 tested, two (Azaserine and Levodopa) were investigated in more detail, paying special attention to the nature of their trypanocidal action and possible route of entry through an amino acid transporter. Azaserine showed a trypanostatic action as well multiple routes of entry into the protozoan interior (as shown by inhibition of glutamine, phenylalanine and tyrosine uptake). The trypanocidal Levodopa showed entry through a tyrosine specific transporter. However, it is possible that Levodopa’s trypanocidal activity may not be as a result of the analogue itself, but secondary products of the analogue. Amino acids are important for protozoa as energy sources as well as forming pools of soluble osmolites. Amino acid usage in trypanosomes was investigated. Upregulation of proline transport and catabolism in response to reduced glucose availability was exhibited by the genome strain of T. brucei. Moreover, this metabolic shift could be mimicked by addition of GlcNAc to the medium, which blocks the hexose transporter limiting glucose entry to the cell. Systems biology approaches were initiated to investigate the undergoing metabolic changes. More specifically, mass spectrometry methodologies were employed to investigate underlying metabolite changes in procyclic form trypanosomes grown in differing medium.
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Wallace, Lynsey J. M. "Biochemical and molecular characterisation of purine transporters of Trypanosoma brucei brucei." Thesis, University of Glasgow, 2004. http://theses.gla.ac.uk/6546/.
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This thesis describes the elucidation and comparison of substrate recognition relationships for the H2 nucleobase transporter of T. b. brucei and the main nucleobase transporter of human erythrocytes. Using standard transport kinetics, application of the Cheng-Prusoff equation and a derivation of the Nernst equation, it was possible to determine the Gibbs free energy (DG°) for the interactions of purine analogues with each transporter, which allowed predictions about the nature of the interactions that are essential for uptake. A range of unusual tricyclic and "fleximer" purine analogues was also assayed for ability to interact with the various purine transporters in T. b. burcei and human erythrocytes. This provided further insights into the extent that the substrate-binding pocket can accommodate unusual and large substrates. Some of the purine analogues used for the substrate-recognition study also displayed limited trypanocidal activity in vitro. More importantly, these results provide a foundation for the design and development of purine nucleobase analogues with anti-trypanosomal action that are efficiently and selectively accumulated by the parasite. One of the main aims of the project was to clone and characterise nucleobase transporters from T. b. brucei. The initial functional complementation strategy in nucleobase-transport deficient trypanosomes proved unsuccessful due to the presence of an additional, previously uncharacterised purine transporter in the trypanosome selection background and other technical obstacles. Homology searching of the T. b. brucei genome database led to the identification of a sequence with substantial similarity to the Adenosine Transporter 1 (TbAT1) gene previously shown to be responsible for the P2 nucleoside transport activity. The AT-like sequence was cloned, functionally expressed in heterologous systems (Saccharomyces cerevisiae and Xenopus oocytes), and characterised as the high-affinity Nucleobase Transporter 1 (TbNBT1). This also marked the first time a nucleobase-specific transporter had been cloned and characterised from any protozoan.
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Gomes, Véronique. "Structure et propriétés interactives de l'antigène variable de Trypanosoma brucei brucei." Lille 1, 1988. http://www.theses.fr/1988LIL10050.
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GONÇALVES, Daniel José Dias. "Efeito da minociclina em Mus Musculus infectados com Trypanosoma brucei brucei." Master's thesis, Instituto de Higiene e Medicina Tropical, 2011. http://hdl.handle.net/10362/11418.
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As patologias provocadas tanto em humanos como em outros mamíferos, pelo parasita hemoflagelado Trypanosoma brucei são um verdadeiro flagelo em África, ma-tando milhares de pessoas e cabeças de gado todos os anos. No caso da terapêutica hu-mana, todas as drogas foram implementadas em meados do século XX, sem novas pa-tentes desde 1981. Urge portanto a descoberta de novas moléculas, que em esquema monoterapêutico ou em associação, possam de alguma forma intervir no controlo do parasita ou contra a inflamação provocada pelas sucessivas ondas de parasitémia.
Em estudos anteriores a minociclina, tetraciclina de 2ª geração, provou ser eficaz na protecção do sistema nervoso central (SNC) de ratos infectados com Trypanosoma brucei brucei (T.b.brucei), diminuindo a passagem pela barreira hemato-encefálica (BHE) de leucócitos e parasitas. No presente estudo, o efeito dessa droga parece estar relacionado com uma maior resistência à perda de vários componentes hematológicos como eritrócitos, leucócitos ou granulócitos em amostras de animais com vinte dias (20 DPI) de progressão de infecção com o parasita. Também as parasitémias são substanci-almente mais baixas (cerca de dez vezes menores) nos animais tratados em 20 DPI. Em termos das citocinas interleucina 4 (IL-4), interferão gama (IFN-γ) e óxido nítrico (NO), parece existir um padrão de secreção diferente nos animais tratados e não tratados. A IL-4 parece neste caso estar associada a um perfil anti-inflamatório; o NO, importante no controlo do parasita, existe em maiores quantidades nos animais tratados, ao contrá-rio do IFN-γ com quantidades mais elevadas nos animais controlos. Esta última citocina está escrita na literatura como factor de crescimento parasitário.
A expressão de metaloproteinases é aparentemente superior no baço quando comparada com tecido hepático, contudo sem aparentes diferenças entre os dois grupos persisitindo um sistema de dupla banda compreendidas entre r de 30 e 40 kDa, valores
de massa molecular, na maioria dos animais dos dois grupos. As metaloproteinases po-dem se endógenas do hospedeiro, mas com elevada possibilidade de serem secretadas pelo parasita no seu processo de invasão tecidular.The pathologies of humans and other mammals caused by the haemoflagelate parasite Trypanosoma brucei are a true burden in Africa, killing thousands of people and cattle every year. In the case of human therapeutics, every drug was implemented in the mid-twentieth century, with no new patents being registered since 1981. It is urgent, therefore, to discover new molecules which in a monotherapeutical scheme or in associ-ation with other drugs can somehow intervene in the control of the parasite or the in-flammation caused by successive waves of parasitaemia. In previous studies, minocycline, which is a second generation tetracycline, has proven effective in the protection of the central nervous system (CNS) of infected mice, impeding the passage of the blood-brain barrier (BBB) for both leukocytes and para-sites. In the present study, the effect of this drug seems to correlate with a greater re-sistance to the loss of several haematological components like erythrocytes, leukocytes or granulocytes in samples from animals with 20 days of progression of T. brucei infec-tion. Also, the parasitaemias seem to be substantially lower (10 fold) in treated animals for the same time of infection and for the cytokine pattern, interleukine 4 (IL-4), inter-feron gamma (IFN-γ) and nitric oxid (NO), for which there seems to be a different se-cretion pattern when comparing treated and untreated animals. IL-4, which has a dubi-ous role in the infection by trypanosomes, seems to be related with an anti-inflammatory profile, and NO, essential to control the parasite, exists in greater quanti-ties in treated animals, unlike IFN-γ which displays higher levels in control animals. The latter is described in the literature as a parasite growth factor. The proteinase expression is greater in the spleen, however there are no obvious differences between the two groups, while there is a persistence of a system of two pro-teinases with molecular masses comprised between 30 and 40 kDa in almost all of the samples, which can be endogenous. Yet, there is a strong possibility that this metallo-proteinases can be secreted also by parasites, helping their tissue invasion.
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Abdullah, Yuzilawati. "Export oriented refinery : a viable option for Brunei Darussalam?" Thesis, University of Dundee, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.505605.
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Aziz, Haji Muhammad Majdi Pehin Dato Haji Abdul. "Baseline study on chemical composition of Brunei Darussalam rivers." Thesis, Brunel University, 2005. http://bura.brunel.ac.uk/handle/2438/4820.
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The research provides data of pH and conductivity, some anions (e. g. fluoride, chloride, bromide, nitrate, phosphate and sulphate), monovalent cations (e. g sodium, ammonium and potassium), divalent cations (e. g calcium and magnesium) heavy metals (e. g. iron, copper, zinc, nickel, cobalt, cadmium and manganese) and organic compounds – from water samples of rivers of Brunei Darussalam, namely, Brunei River, Belait River, Tutong River and Temburong River. The higher values of certain parameters with respect to the acceptable standard limits for river water indicate the pollution in river water samples of the study area, make the waters unsuitable for various applications and do pose a human health hazard. The pH levels in Brunei Darussalam is quite reassuring and mostly safe. Although there are some stretches of rivers that show slightly lower levels of pH, there is no cause for any alarm as these waterways are not sources of drinking water. As for anions and cations, the only anion of significant levels detected in Brunei Rivers is chloride whereas only monovalent cation detected in significant levels, is sodium. The concentrations of chloride and sodium ions are below the standard concentrations. Brunei Rivers are still free from chloride and sodium pollution. For heavy metals, only iron is detected in Brunei Rivers. Brunei being a oil based country experiments were done to identify levels of a numbers of significant toxic organic compounds, including, toluene and benzene which have been detected in the waters of the oil mining district of Belait District but are within normal limits. The use of a photolytic cell system to achieve the photodegradation of benzene, toluene, ethylenediaminetetra-acetic acid (EDTA) and the surfactant – hexadecyltrimethyl-ammonium bromide (C19H42NBr) is reported. The system has been optimised by investigating the effects of the addition of hydrogen peroxide (H202) as an oxidant and the addition of titanium dioxide (TiO2) as a catalyst. The results show that the photolytic system can be used to achieve >99% degradation of organic contaminants. The research also includes a final chapter on management system which covers water protection, pollution control and solid waste management in Brunei. In addition to investigating various factors of the solid waste management in Brunei, the researcher has also exposed some of the weaknesses that need immediate addressing. Various measures have been suggested to make Brunei's water more efficient. Moreover, ways of preserving the high quality of Brunei's water figures in this chapter.
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Bakar, Mataim. "The phonotactics of Brunei Malay : an optimality-theoretic account." Thesis, University of Essex, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.343577.
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Hj, Besar Mohd Hairul Azrin. "Exploring the governance of Takaful (Islamic insurance) in Brunei." Thesis, University of Glasgow, 2017. http://theses.gla.ac.uk/7810/.
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The prohibition of insurance as specified in the conventional business model has led to Takaful being established for the Muslim community to fulfil their accountability/obligations towards Allah. The absent of a contract in Takaful, a replacement of the conventional sale contract in insurance has resulted in the emergence of Muamalah contracts as a basis for contractual structures and this bear the minimum acceptable requirement of Shariah. The attainability of such contractual structures to be used in Takaful had been unstable in the sense that it needs various reviews, and this has occurred precisely because it has been laden with both Shariah compliance and operational issues detaching the contracts from its original Shariah and economic substances. This research explores how the governance of Takaful in Brunei considered and adapted unstable contractual structure for Takaful operation inciting the divergence from the fundamental principles of Shariah. The main objective of the research is to explore the governance of Takaful in Brunei. The research seeks to identify and analyse the factors that influence the adaption of the Takaful contractual structure, examine the logics behind the current governance framework, and investigate the disclosure of information and financial reporting of Takaful. It utilizes the interpretive approach and this is supported by qualitative research methods in the form of interviews, participant observation and document review. The thesis also uncovers the causal factors of the necessity to adapt unstable contractual structure, and this in turn raises the concern of how Takaful is governed. In this work neo institutional theory of institutional isomorphism is used to identify these factors and the manner in which they influence the adaption process. In addition, the logical reference exhilarating the governance framework of Takaful is examined through the lens of institutional logic theory to understand why it has not been possible to alleviate concerns surrounding the adaption of the contractual structure. The analysis also extends to unravel the core logics of governance driving Takaful disclosure and financial reporting. Empirical findings show that the Brunei government has been the main driving factor in terms of adapting the current contractual structure during the initial creation of Takaful in Brunei. Ironically conventional insurance has been used to define the boundaries for structuring the contractual model for Takaful to replace conventional insurance model. Other factors at the macro (e.g. government influence), meso (e.g. the industry) and micro (e.g. between the companies and within each company) levels have also influenced the current contractual structure through the main three forces: coercive (e.g. government enforcement), normative (e.g. Legal Framework) and mimetic (e.g. following other Takaful operators). Decoupling the substance of the contract and actually implementing it is masked by the Shariah governance responsible for approving the individual contracts without evaluating the whole business structure from the Shariah perspective. The business and Shariah logics are the main dominance of Takaful governance frame of reference. Separation between these two logics served as sustainable force for its ability to reflect the compliance status desired by the industry. This creates trust in governance and an environment of adhering to Shariah in good faith. Disclosure and financial reporting decisions are driven by the regulatory, market and Shariah logics, where the regulatory logic dominates the mandatory disclosures. Finally, in evaluating these factors that influence the governance of Takaful in Brunei the thesis offers options of how to improve the contractual structure and addressing concerns thereof.
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Blondin, Catherine. "Polysaccharides sulfatés extraits d'algues brunes : activité anticomplémentaire des fucanes." Paris 13, 1992. http://www.theses.fr/1992PA132041.
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Les fucanes sont des polysaccharides sulfatés présents dans la paroi des algues brunes ; majoritairement constitués d'unités -1,2-l-fucose-4-sulfate. Une étude antérieure de leur mécanisme d'action anticoagulante, ainsi que la réalisation de tests in vivo et ex vivo, ont permis d'envisager l'utilisation thérapeutique des fucanes, en tant qu'agent antithrombotique dans la prévention des maladies thromboemboliques. La première partie de notre étude a donc consisté à assurer que le procédé de purification des fucanes, mis en place à l'échelle pilote, était fiable et reproductible. Nous avons pour cela analyse sept lots successifs de fucanes fractionnes, d'un point de vue physicochimique (masse molaire chromatographique, teneurs en fucose, acide uronique, sulfate, oses neutres et protéines), et d'un point de vue biologique (activité anticoagulante). Les résultats nous ont permis de sélectionner un compose de masse molaire apparente 20 000 g/mol, bien défini quant à sa composition chimique et son activité anticoagulante spécifique. Dans un deuxième partie, nous avons examiné l'effet des fucanes sur le système du complément. Le complément est un système protéique complexe qui participe aux défenses immunitaires de l'organisme. Il est composé d'au moins 11 composants dont l'activation en cascade, contrôlée par 9 protéines régulatrices, est à l'origine d'activités biologiques diverses (élimination des bactéries, des virus, opsonisation, participation a la réaction inflammatoire). L'activation anarchique de ces protéines peut survenir dans certaines pathologies (glomérulonéphrites aiguës, lupus érythémateux disséminé) ou être associée à certains traitements (circulation extracorporelle, hémodialyse). L'étude que nous avons effectuée en sérum humain ou en présence de protéines purifiées, a montré que les fucanes possèdent un fort pouvoir inhibiteur de l'activation du complément, de 15 a 90 fois supérieur a celui de l'héparine. Les deux séries de 10 et 13 fractions que nous avons préparées ont été analysées, leur action s'exerce sur les deux voies d'activation du complément et dépend de la masse molaire des fractions. En système semi purifié, les fucanes inhibent la formation de la c3 convertase classique, en empêchant le clivage de la protéine c4 par la sous-unité cls et en inhibant la liaison de la protéine c2 sur le fragment c4b. A même concentration pondérale que l'héparine, ils inhibent la formation des c3 convertases alternes, en inhibant de façon compétitive la liaison de la protéine b sur le fragment c3b. Quand la c3 convertase est stabilisée par la properdine, les fucanes, mieux que l'héparine, catalysent la dissociation des complexes c3bbbp ce qui suggère un effet direct de ces polyanions sur la properdine.
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Vidaurre, Spotorno Evelia. "Formas de resistencia en la narrativa de Marta Brunet." Tesis, Universidad de Chile, 2012. http://www.repositorio.uchile.cl/handle/2250/113733.
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Tesis para optar al grado de Magíster en LiteraturaEn la presente investigación me centraré en la narrativa de Marta Brunet. Es interesante releer su obra, así como recordar lo importante que ha sido y es para las letras chilenas. Considero fundamental poner en vigencia la importancia de su propuesta, pues los personajes y el tratamiento de los temas por los que transita develan a una escritora contemporánea que sobrepasa los límites del criollismo o la evolución del mismo. En esta investigación daré especial importancia a las relaciones de “poder” presentes en sus relatos, especialmente en ciertas formas de resistencia a ese poder establecido social y culturalmente. El corpus de investigación consta de los siguientes textos: de su libro Aguas abajo, los cuentos “Soledad de la sangre”, “Piedra callada” y “Aguas abajo”; por otro lado, su primera novela Montaña adentro. La elección considera la riqueza de éstos para tratar el tema del poder y su relevancia desde el punto de vista de la hipótesis que propondré.
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Haji-Othman, Noor Azam. "Linguistic diversity in Negara Brunei Darussalam : an ecological perspective." Thesis, University of Leicester, 2005. http://hdl.handle.net/2381/30897.
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Despite its tiny size and population, Brunei Darussalam is linguistically and ethnically diverse. The dominant race, the Malays, is made up of seven different ethnic groups, namely Belait, Bisaya, Brunei Malays, Dusun, Kedayan, Murut and Tutong, all of whom are considered indigenous to Brunei. With the exception of the Brunei Malays and Kedayans, each of the other groups traditionally speaks their own distinct indigenous languages that are distinct from the Malay language. Drawing on qualitative data obtained through interviews and documentary analysis, this study aims to explore the historical and contemporary interrelationships between these languages within the 'ecology of language' framework, and to find out how the notion of linguistic diversity interplays with national unity in the face of modernization. Although the study reveals a high level of tolerance by the informants toward linguistic diversity, there is evidence to suggest that as the minority ethnic population are abandoning their traditional languages and shifting to Malay, a synchronous convergent evolutionary process of identity shift is occurring too. The implications are that as linguistic diversity is diminishing in Brunei, so too is cultural diversity.
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Verdier, Caroline. "A study of the novels of Elisa Brune." Thesis, University of Strathclyde, 2011. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=16827.
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This thesis studies the novels of contemporary Belgian writer and journalist Elisa Brune (b. 1966) and the ways in which they provide the readership with a partial yet effective representation of some institutions and issues found in contemporary Western societies. We first trace the developments of the Belgian historical and literary scene since the country came into existence in 1830 in order to establish the context in which Elisa Brune currently writes, as well as her potential influences and sources of inspiration. Our analysis then turns its attention to the various conventional and more innovative genres Brune has tackled so far and how each is in its own way connected to an aspect of science, history and/or socio-cultural reality. We finally investigate a series of themes present in five of Brune’s novels written between 2000 and 2005, with a view to establishing how Brune’s almost scientific approach to writing, in its objective and descriptive way, aims to remain close to a certain type of realism and trigger reader response. The themes examined in detail in our analysis of Brune’s narratives are the representations of the institution of family (types of families, relationships and problems), education and how women gradually gained access to it and to work, and various forms of relationships (consensual or not) between men and women. Through these themes, we argue that Brune depicts several issues, behaviours and tendencies she has observed in societies and which can be problematic for individuals. Our study draws on sociological, psychological and feminist standpoint theories to establish how Brune’s various representations can be deemed effective and may have an impact on her readership.
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Bruce, Melanie Bundick. ""Far more than I ever dared to hope for" : Victorian traveler Isabella Bird in the Rocky Mountains /." Electronic version (PDF), 2003. http://dl.uncw.edu/etd/2003/brucem/melaniebruce.pdf.
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Lau, Hon Chung. "Fishers of men in the abode of peace missiological reflections on Brunei Darussalam /." Theological Research Exchange Network (TREN) Access this title online, 2002. http://www.tren.com.
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Kifle, Hazri Haji. "Public sector innovation: the case of E-Government in Brunei." Thesis, University of Manchester, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.491764.
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5203 L $$aInnovation in the pub blic sector is an under-researched area. 'Innovation" and "public sector tend to be viewed as mutually exclusive, while innovation is seen to be essential for the private sector. The emergence of the potential of Information Communication Technology (ICT), which has been strongly taken up in the private sector to transform business processes and employment and create new industries, has triggered policy makers to emulate the same success stories in the public sector, pushed by vendors. Many governments have adopted ICTin the form of electronic (e) government to reform or transform their public sectors mainly to provide better service internally (Government to Government) and externally (Government to Citizens and Business).
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Cane, Graeme. "A linguistic description of spoken Brunei English in the 1990s." Thesis, University of Strathclyde, 1993. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=21242.
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The thesis discusses the variety of English that is spoken today in Brunei Darussalam and assesses its status as a 'New English'. Using a corpus of spoken data which was recorded and transcribed by the author, the thesis attempts to produce an empirically based linguistic description of the grammatical, lexical and discourse features found in spoken Brunei English and to discuss the ways in which these features differ from the equivalent features in Standard British English. The final part of the study is concerned with the pedagogical and language planning implications of recognizing the existence of a Bruneian variety of English, and with proposing an appropriate English language teaching model for the Bruneian education system.
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Salleh, Ak Mohd Hasnol Alwee. "Exploring an inclusive Islamic financial planning framework in Brunei Darussalam." Thesis, Durham University, 2013. http://etheses.dur.ac.uk/8501/.
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The 1970s has witnessed two novel developments in the realm of personal finance and Islamic finance. Within personal finance, the decade saw a growth in the demand for financial planning, moving from a sector that prior to the 1970s catered exclusively to the wealthy, to one that provides services to the middle-income class. In the field of Islamic finance, the decade is remembered for the establishment of the first Islamic bank and takaful (insurance) company that laid the foundations of an industry that is now reported to be a trillion dollar industry. This study is designed to explore if Islamic financial planning, which falls within the purview of Islamic finance, can be developed further to include those with low incomes and in poverty. The aim of this study is to examine the needs of the poor and non-poor households in order to identify, describe and establish an inclusive Islamic Financial Planning (IFP) framework for both groups in Brunei Darussalam. This suggested framework integrates historical institutions such as zakat and awqaf, with contemporary financial concepts and approaches such as financial exclusion and financial planning. In order to achieve the research aim, primary data was collected using structured interviews/questionnaire-based surveys and semi-structured interviews. The former, quantitative method, involved interviews with 431 Muslim heads of households in the Brunei-Muara district, composed of 216 non-welfare recipients (non-poor or net surplus households) and 215 welfare recipients (poor or net deficit households). The data was analysed using statistical techniques, which include Pearson’s chi-square test and logistic regression. Meanwhile, the qualitative information gathered from semi-structured interviews with 39 net deficit respondents was coded and reported. The findings of the study display a hierarchical form of financial planning, for the poor and non-poor in Brunei. For net deficit households, the hierarchical structure involves moving individuals from the bottom of the hierarchy, that is the money management level, to emergency planning, and finally to the top of the hierarchy, that is investing for goals. For net surplus households, their role relates to the supply-side of the inclusive IFP framework, whereby they provide funds necessary in the form of zakat and awqaf to implement the approaches associated with money management, emergency planning and investing for goals. The study also found instances of financial exclusion in Brunei for net deficit respondents in opening bank accounts and accessing credit facilities. In terms of financial planning practices and financial knowledge, the findings highlight net deficit respondents were more likely to fare poorly than net surplus respondents. Further, in terms of zakat and awqaf, both groups of respondents appear to have low-level understanding of these concepts. Overall, the study provides the conceptual framework for an inclusive IFP approach in Brunei. Thereby, it provides a different paradigm towards combating poverty, through the lens of financial planning, alongside the added components of zakat, awqaf, financial literacy and financial inclusion.
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Vencato, Massimo M. "Development and validation of the Brunel lifestyle physical activity questionnaire." Thesis, Brunel University, 2009. http://bura.brunel.ac.uk/handle/2438/4446.
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The purpose of the present programme was to develop and validate a theoretically-grounded instrument to measure the planned and unplanned dimensions of lifestyle PA (PPA and UPA; Dunn, Andersen, & Jakicic, 1998). In Study 1, two samples of British adults (Internet: N = 742; paper: N = 563) were used to establish the content validity of the Brunel Lifestyle Physical Activity Questionnaire (BLPAQ). Exploratory factor analysis yielded a two-factor model (UPA and PPA) that produced acceptable fit indices using confirmatory factors analyses with both samples. The purpose of Study 2 was to examine the test-retest reliability of the BLPAQ over 5 weeks using a sample of leisure centre users, university staff members, and university students (N = 337). High correlations were observed between the two administrations (range = .93-.98; p < .01). Thereafter, the data were subjected to proportion of agreement (PoA) analysis as advocated by Nevill, Lane, Kilgor, Bowes, and Whyte (2001). Both PPA and UPA demonstrated satisfactorily high internal agreement (PoA > 95%). In Study 3, the BLPAQ was cross-validated using two criterion measures: the Baecke Questionnaire of Habitual Physical Activity (Baecke, Burema, & Frijters, 1982) and the Godin’s Leisure-Time Exercise Questionnaire (Godin & Shephard, 1985). Multiple linear regressions were performed to predict PPA and UPA from the subscales of the two reference measures. The predictive models differed markedly in terms of gender. Subsequently, the sample of 338 British adults was divided into two subsamples, and these were subjected to a cross-validation using the Limits of Agreement (LoA) methodology advocated by Bland and Altman (1986). The agreement plots revealed that both BLPAQ subscales demonstrated acceptable inter-sample agreement when compared to the criterion measures. In Study 4, a series of structural equation models were tested with the aim of predicting PPA and UPA using the variables that constitute the Theory of Planned Behaviour (TPB). The TPB was able to predict PPA but not UPA. The addition of a direct path between past behaviour to UPA did not result in a significant prediction. Further work is required to examine the factorial structure of the PPA subscale and to increase the number of items in the UPA subscale. In sum, the programme has contributed a valid and reliable theory-based measure of PA as well as evidence to support the utility of the TPB in PA research. However, the TPB framework may require the addition of predictors such as past behaviour and actual behavioural control.
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Haji, Morni Hajah Asmah. "The quality of teaching and learning processes in Brunei preschools." Thesis, University of Exeter, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.341190.
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Haji, Saim Hajah Sainah. "The administrative system of Brunei Darussalam : management, accountability and reform." Thesis, University of Exeter, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.322383.
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Latif, Mohammad. "Innovation in university education : a case study of Brunel University." Thesis, University of Cambridge, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.292836.
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