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Journal articles on the topic 'Bryophyllum Pinnatum and therapeutic use'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Chetan, Nagar, Nagar Kuldeep, Nagar Abhishek, and Kumar Vyas Girish. "Therapeutic Potential of Bryophyllum Pinnatum (Kalanchoe Pinnata) Leaf Juice in the Management of Kidney Stones: A Natural Remedy for Urolithiasis." Career Point International Journal of Research(CPIJR) 4, no. 3 (2025): 1–6. https://doi.org/10.5281/zenodo.15054370.

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This study investigates the therapeutic potential of Bryophyllum pinnatum (Kalanchoe pinnata) leaf juice in the management of kidney stones (urolithiasis). Phytochemical evaluation identified bioactive compounds such as alkaloids, flavonoids, saponins, phenolic compounds, and carbohydrates, contributing to its antioxidant, anti-inflammatory, and diuretic properties. The juice demonstrated high antioxidant activity, comparable to ascorbic acid, and effectively inhibited calcium oxalate crystal formation, supporting its use in kidney stone management. Microbial load analysis confirmed its safety

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Rahman, Perdana Aditya, Mokhamad Fahmi Rizki Syaban, Salsabila Ghina Anoraga, and Faradilah Lukmana Sabila. "Molecular Docking Analysis from Bryophyllum pinnatum Compound as A COVID-19 Cytokine Storm Therapy." Open Access Macedonian Journal of Medical Sciences 10, B (2022): 779–84. http://dx.doi.org/10.3889/oamjms.2022.8412.

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BACKGROUND: Cytokine storm is a condition that typically develops during severe COVID-19 viral infection and contributes cause of death. Bryophyllum pinnatum is a herbal medicinal that has an impact as an anti-inflammatory agent. B. pinnatum may be used as a therapeutic agent for cytokine storms. AIM: We were investigating the molecular interactions of B. pinnatum active compounds with cytokines involved in COVID-19 infection. METHODS: We did the molecular docking approach using the active chemicals from Bryphyllum pinnatum, which was available on the PubChem website. Meanwhile, the protein ut

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Michely, Railma Costa Costa, and Matheus Silva Alves Dr. "ATIVIDADES ANTI-INFLAMATÓRIA E ANTI ULCEROGÊNICA DA BRYOPHYLLUM PINNATUM, NO TRATAMENTO DA GASTRITE." Revistaft 27, no. 123 (2023): 28. https://doi.org/10.5281/zenodo.8017628.

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<strong>INTRODUÇÃO</strong>: A gastrite é uma inflamação do revestimento interno do estômago. Pode ser aguda, quando aparece de repente e dura pouco, ou crônica, quando se instala aos poucos e leva muito tempo para ser controlada. <strong>OBJETIVOS</strong>: Apresentar as evidências do potencial biológico da planta <em>Bryophyllum pinnatum</em> para o tratamento da gastrite. <strong>MÉTODOS</strong>: Foi uma revisão integrativa da literatura dos últimos 10 anos, ou seja dentro da faixa temporal

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Uahomo, Precious Ojo, and Joshua Charles Isirima. "Attenuating Ketamine-Induced Nephrotoxicity with Bryophyllum pinnatum Extract: Biochemical and Histological Investigation." Journal of Complementary and Alternative Medical Research 26, no. 1 (2025): 21–36. https://doi.org/10.9734/jocamr/2025/v26i1612.

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Background: Ketamine, a widely used anesthetic agent, has been shown to induce nephrotoxicity, characterized by increased kidney function markers and structural damage. Despite its therapeutic applications, the adverse effects of ketamine on the kidneys necessitate the exploration of potential protective agents. Bryophyllum pinnatum (B. pinnatum), an herbal plant with a long history of medicinal use, has demonstrated various therapeutic properties, including antioxidant, anti-inflammatory, and nephroprotective effects. However, its role in mitigating ketamine-induced kidney damage remains inad

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Dhumane, Saurabh, Tejas Naik, Mahesh Shelke, Kiran Dukare, and Krushna Dhongade. "Exploring the Therapeutic Potential: Phytochemistry and Pharmacology of Bryophyllum pinnatum." Journal of Drug Delivery and Therapeutics 14, no. 2 (2024): 171–77. http://dx.doi.org/10.22270/jddt.v14i2.6282.

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Bryophyllum pinnatum, a renowned medicinal plant with a rich history in various traditional medical practices, has been utilized for treating a range of ailments such as fever, smallpox, otitis, cough, asthma, headache, convulsion, and general debility. The plant's diverse secondary metabolites, including steroids, flavonoids, terpenoids, fatty acids, bufadienolides, proteins, peptides, vitamins, and polysaccharides, have been identified. Over the past thirty years, extensive research has unveiled the plant's pharmacological effects both in vivo and in vitro, demonstrating its antimicrobial, a

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Umarudeen, A. M., M. G. Magaji, F. Khan, and A. Abubakar. "Acute Toxicity and Anxiolytic Activity Screening of Hydroalcoholic Leaf Extracts of Bryophyllum pinnatum, Terminalia catappa and Tapinanthus dodoneifolius Growing on Terminalia catappa Tree in MIce." International Neuropsychiatric Disease Journal 19, no. 3 (2023): 22–34. http://dx.doi.org/10.9734/indj/2023/v19i3374.

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Aims: Hydroalcoholic T. dodoneifolius, B.pinnatum and T. catappa leaf extracts were investigated for their acute toxicity and anxiolytic activities. Study Design: Acute toxicity (LD50) was determined using the limit dose acute and Anxiolytic activities were assessed by open-field field behavioural testing in mice. Place and Duration of Study: The study took place in the Neurobehavioural room of Department of Pharmacology & Therapeutics, Faculty of Pharmacy, Ahmadu Bello University, Zaria in late December 2022. Methodology: Groups of mice (n=6; equal sexes) were each exposed to the open-fie

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Mahendra, Siddheshwar Shendkar*1 Lahoo Palve2 Leena Parkhi3 Lalit Ambhore4 Manish Bhosale5 Snehal D. Kothavale6 K. V. Otari7. "Review On Bryophyllum Pinnatum." International Journal in Pharmaceutical Sciences 2, no. 4 (2024): 380–85. https://doi.org/10.5281/zenodo.10935311.

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Bryophyllum pinnatum is widely used in Ayurvedic system of the medicine as astringent. The plant is widely use in traditional medicine for treatment of various ailments and well known for its haemostatic and wound healing properties. It is an indigenous and exotic plant. plant is found naturally through the country. It is succulent, herb, leaves are variable size and leaflets are elliptic. The leaf extract of Bryophyllum pinnatum has been reported to possess antihypertensive, antiulcer properties. Herbal leaves of Bryophyllum pinnatum, family Crassulaceae possesses antioxidant, antimicrobial,

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Hamburger, Matthias, Olivier Potterat, Karin Fürer, Ana Paula Simões-Wüst, and Ursula von Mandach. "Bryophyllum pinnatum – Reverse Engineering of an Anthroposophic Herbal Medicine." Natural Product Communications 12, no. 8 (2017): 1934578X1701200. http://dx.doi.org/10.1177/1934578x1701200847.

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Bryophyllum pinnatum (syn. Kalanchoe pinnata), a plant native to Madagascar, was introduced into anthroposophic medicine in the early 20th century. In recent years, a number of investigations were conducted on the chemical composition, pharmacological properties, and clinical efficacy of Bryophyllum. Here the phytochemistry, and pharmacological and clinical data are reviewed. With respect to pharmacology, a special focus was put on properties related to the use in anthroposophic medicine as a treatment for “hyperactivity diseases”, including preterm labor, restlessness, and sleep disorders. Re

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DivyaPandit, Pawar, Mr Abhijit Rode Sir, and Mr Akshay Jadhav Si. "Pharmacological Activity of Bryophyllum Pinnatum." International Journal of Pharmaceutical Research and Applications 10, no. 1 (2025): 08–15. https://doi.org/10.35629/4494-10010815.

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Bryophyllum pinnatum is a medicinal plant used in traditional medicine to treat many health problems. Studies show it has healing properties like reducing inflammation, fighting bacteria, preventing cancer, and speeding up wound healing. It can also help with kidney stones and diabetes. The plant contains natural compounds that give it these benefits. Although it's effective in traditional medicine, more research is needed to understand its full potential and ensure it’s safe for modern medical use.

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Itaman, V. O., R. C. Osaro-Matthew, and B. O. Umeojinkeya. "Antimcrobial activity of extract of Bryophyllum pinnatum and Citrus aurantifoliaon some selected pathogens." Scientia Africana 21, no. 1 (2022): 53–66. http://dx.doi.org/10.4314/sa.v21i1.5.

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The inhibitory properties of Bryophyllum pinnatum and lime juice on some selected microorganisms (Staphylococcus aureus,Streptococcus pyogenes, Escherichia coli, Klebsiella pneumoniae, Aspergillus niger and Candida albicans) were investigated. The various concentrations of the extracts were prepared by double dilution method while the ability of the various extracts to inhibit the growth of the pathogenic organisms was determined using the agar well technique. The highest in-vitro antimicrobial activity of methanolic extract of Bryophyllum pinnatum was (13.0+2.83a mm at 200 mg/ml) against Kleb

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Muoneke Odinaka Anthony, Yetunde Oluwafunke Aina, Kelechi Purity Ezennubia, Rotimi Oluyemi Malomo, and Shuaib Olawale Emmanuel. "Antiulcerogenic effect of the methanolic extract of Bryophyllum pinnatum on the indomethacin induced gastric ulceration in male albino rats." Magna Scientia Advanced Biology and Pharmacy 15, no. 1 (2025): 079–88. https://doi.org/10.30574/msabp.2025.15.1.0048.

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Plants which are medicinal used in traditional medicine contain a diverse range of materials that can treat and provide care to many diseases. The aim of this study is to evaluate the antiulcer activities of the methanolic extract of leaves of Bryophyllum pinnatum in indomethacin-induced male albino rats. In this experiment, 42 rats were divided into six (6) groups with 7 rats in each group. Group A (Negative control) was given Indomethacin 40mg/kg b.wt, Group B pretreated with 20mg/kg b.wt of Cimetidin (antiulcer drug) and Groups C, D, E and F were pretreated with 10, 20, 30 and 40 mg/kg b.wt

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Samrin, Sheikh* Nikita Bhandakkar Pallavi Khairkar Renuka Mahajan. "Pharmacological and Phytochemical Profile of Bryophyllum Pinnatum." International Journal of Pharmaceutical Sciences 3, no. 2 (2025): 876–82. https://doi.org/10.5281/zenodo.14859610.

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Bryophyllum pinnatum, commonly known as the Air Plant or Life Plant, is a succulent species exhibiting remarkable resilience and adaptability. Native to tropical Africa, this plant has evolved unique physiological and morphological traits, enabling it to thrive in challenging environments. Studies have demonstrated Byrophyllum pinnatum’s potential in traditional medicine, particularly in treating wounds, inflammation, and infections. Its antioxidant, anti-inflammatory, and antimicrobial properties make it a valuable subject for further research. Additionally, its ability to purify air an

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Kalio, Ibiene Sarah, Echeonwu Victoria Chidinma, and Margret Deinma Aleru-Chuku. "Effect of Bryophyllum pinnatum Leaf Extract Consumption on Lipid Concentrations and Cardiovascular Risk Indices in Apparently Healthy Individuals." Asian Journal of Biochemistry, Genetics and Molecular Biology 13, no. 4 (2023): 40–48. http://dx.doi.org/10.9734/ajbgmb/2023/v13i4302.

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Bryophyllum pinnatum has been consumed locally for various ailments without proper documentation of It’s effect on Lipid concentrations and cardiovascular risk indices in humans. This study sought to determine the effect of Bryophyllum pinnatum leaf extract consumption on lipid concentrations and cardiovascular risk indices in apparently healthy individuals by estimating Total cholesterol, Triglycerides, High Density Lipoprotein (HDL), Low Density Lipoprotein (LDL), Atherogenic Index of Plasma (AIP), Castelli Risk Index I and II, Total protein and Albumin in 15 apparently healthy individuals a

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Tomar, Amit. "Medicinal Use of Bryophyllum pinnatum Kaurz. to Cure Cholera." Journal of Non Timber Forest Products 23, no. 2 (2016): 109–10. http://dx.doi.org/10.54207/bsmps2000-2016-4b6s4b.

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15

Kshirasagar, Shivaraj, Suneel Dodamani, and Abhijit Bhatkal. "Identification of potential DPP-4 inhibitors from Bryophyllum pinnatum by in-silico analysis." International Journal of Ayurvedic Medicine 15, no. 1 (2024): 226–37. http://dx.doi.org/10.47552/ijam.v15i1.4316.

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Background: An estimated 463 million people already live with diabetes and that figure is set to rise to over 700 million by 2045, as per the International Diabetes Federation (IDF). The current form of treatment for Type-2 DM can be done with sulfonylureas, meglitinides, metformin, thiazolidinediones, incretin mimetics: Glucagon-like peptide 1 (GLP-1), Glucose-dependent insulinotropic polypeptide (GIP), and amylin analogues (Pramlintide). Bryophyllum pinnatum (Lam.) Oken (B. pinnatum) belongs to the plant family crassulaceae used in traditional medicine in Asia. GLP-1 and Glucose-dependant In

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Onoja, Samuel O., Ginika Q. Ihejirika, Oluchi N. Nwankudu, Yusuf N. Omeh, and Maxwell I. Ezeja. "Antidiarrheal and Antioxidant Activities of Methanol Extract of Bryophyllum pinnatum Leaf Harvested from South-Eastern Nigeria in Mice." Journal of Pharmaceutics 2018 (May 29, 2018): 1–6. http://dx.doi.org/10.1155/2018/6810620.

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Bryophyllum pinnatum belongs to the family Crassulaceae and it is commonly used in the ethnomedical practices. This study investigated the antidiarrheal and antioxidant properties of methanol extract of Bryophyllum pinnatum leaf harvested from South-Eastern Nigeria in mice. Cold maceration method in 80% methanol was adopted in the extract preparation. The 2,2-diphenyl-1-picrylhydrazyl (DPPH) and ferric reducing antioxidant power (FRAP) assays were used to evaluate the antioxidant property while castor oil-induced diarrhea, small intestinal transit, and enteropooling models were used for the an

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Hernández-Caballero, Marta Elena, José Alfredo Sierra-Ramírez, Ricardo Villalobos-Valencia, and Emmanuel Seseña-Méndez. "Potential of Kalanchoe pinnata as a Cancer Treatment Adjuvant and an Epigenetic Regulator." Molecules 27, no. 19 (2022): 6425. http://dx.doi.org/10.3390/molecules27196425.

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Cancer is a global public health problem that is related to different environmental and lifestyle factors. Although the combination of screening, prevention, and treatment of cancer has resulted in increased patient survival, conventional treatments sometimes have therapeutic limitations such as resistance to drugs or severe side effects. Oriental culture includes herbal medicine as a complementary therapy in combination with chemotherapy or radiotherapy. This study aimed to identify the bioactive ingredients in Kalanchoe pinnata, a succulent herb with ethnomedical applications for several dis

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Priti, Gadge* Sanika Karale Kashish Patel Somanath Narsale Shubham Gadge. "The Antimicrobial Potential of Bryophyllum Pinnatum Gel." International Journal of Pharmaceutical Sciences 3, no. 2 (2025): 2033–40. https://doi.org/10.5281/zenodo.14934905.

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Bryophyllum pinnatum, a succulent plant with traditional medicinal uses, has been investigated for its antimicrobial properties. Bryophyllum pinnatum gel exhibits antimicrobial properties against a range of microorganisms, including bacteria, fungi, and viruses. This review highlights its potential health benefits, such as accelerating wound healing by reducing infection risk, inhibiting acne-causing bacteria, and potentially alleviating inflammatory skin conditions. Furthermore, it may stimulate the immune response, contributing to overall health. Traditional medicine has explored its potenti

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Nnaebue, Ndirika D., Chikodili G. Anaukwu, Victoria N. Anyaoha, et al. "Comparative Phytochemical Constituents of Extracts of Bryophyllum pinnatum Grown in Anambra State, Nigeria." International Journal of Applied Sciences and Biotechnology 12, no. 1 (2024): 1–7. http://dx.doi.org/10.3126/ijasbt.v12i1.64330.

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Bryophyllum pinnatum is a plant abundant in several phytochemicals, that can be extracted, purified, and packaged for the goal of promoting public health. In this study, the phytochemical composition of the leaf extracts of Bryophyllum pinnatum grown in Anambra State, Nigeria, was compared. B. pinnatum leaves were obtained from a farm in Anambra State, Nigeria. The leaves were processed and extracted using cold water and hot water extraction, methanol extraction, and ethanol extraction. The extraction processes were carried out following standard extraction methods. Preliminary qualitative and

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Bennett, Victoria, Bamidele Martin Amos-Tautua, and Christopher Unyime Ebong. "Proximate, Selected Elements and Bioactive Compounds in Jatropha tanjorensis and Bryophyllum pinnatum Leaves." International Research Journal of Pure and Applied Chemistry 25, no. 4 (2024): 51–64. http://dx.doi.org/10.9734/irjpac/2024/v25i4866.

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A comparative research was performed on two medicinal leaves: Jatropha tanjorensis and Bryophyllum pinnatum collected from Angalabiri community, Nigeria, to ascertain the proximate content, mineral composition, and secondary metabolite profiling in the leaves. The proximate analyses of the leaves of J. tanjorensis and B. pinnatum revealed: moisture (84.87%, 92.66%), ash (7.91%, 1.11%), protein (6.20%, 1.30%), fat (14.54%, 8.40%), fibre (14.67%, 21.31%) and carbohydrate (54.28 %, 24.78%) respectively. Mineral analyses showed: potassium (0.018%, 0.060%), iron (0.134%, 0.003%), manganese (0.001%,

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Sidra, Choudhary*1 Vedanti Bhoir2 Riya Bhoir3 Chanchal Bhoir4. "Bryophyllum Pinnatum Leaf Extract In Treatment Of Kidney Stones." International Journal in Pharmaceutical Sciences 2, no. 1 (2024): 598–600. https://doi.org/10.5281/zenodo.10563390.

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In Asiatic as well surrounding parts of world such as India, China, America, Africa, Bryophyllum pinnatum has been widely used as traditional medication to treat kidney stones i.e., Urolithiasis. Study based on clinical research are carried out to treat lithiasis by consuming fresh leaf juice of B. pinnatum which shows effective results by dissolving (<10mm) of diameter stones. For study 23 patients were taken into consideration and are diagnosed regularly and treated with 10 ml/day x 30 days of oral doses. Urine sample was collected on 30th day of trial and analysed properly. Overall, 85-8

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Odira Johnson, Oledibe,, Amadi, Jude Ezejiofor, Uka Chiedozie Joel, and Nwakuche Adaugo Ozioma. "Fungicidal Potentials of Leaf and Bark Extracts of Bryophyllum pinnatum on Cowpea (Vigna unguiculata L.) Seed Fungi." Asian Journal of Research in Agriculture and Forestry 10, no. 4 (2024): 213–22. http://dx.doi.org/10.9734/ajraf/2024/v10i4330.

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In Nigeria, Cowpea (Vigna unguiculata [L.] Walp) is an important grain legume which besides being a food crop serves as a major source of income for rural households. The action of pathogens on stored seeds causes huge post-harvest and economic losses to cowpea farmers in Nigeria. This research was aimed at isolating and identifying the spoilage pathogens of cowpea seed and testing the potentiality of ethanol extracts of Bryophyllum pinnatum on the isolates. Spoilt cowpea seed samples were purchased from different markets in Anambra State. They were transported to Alpha Research Laboratory, Aw

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Ukoro, B., S. O. Ojeka, O. M. Adienbo, and A. N. Chuemere. "Modulation of BDNF Expression by Bryophyllum pinnatum Extract: Implications for Oxidative Stress and Cognitive Function in Pain-induced Wistar Rats." International Neuropsychiatric Disease Journal 21, no. 5 (2024): 22–31. http://dx.doi.org/10.9734/indj/2024/v21i5446.

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This research work investigated modulatory effects of Bryophylum pinnatum extract on BDNF expression, and cognitive functions in repetitive pain-induced oxidative stress in Wistar rats. Animals weighing between 80–100g were acquired from the animal house of the Department of Human Physiology, Faculty of Basic Medical Sciences, University of Port Harcourt, and all animals received standard laboratory rat feeds and water ad libitum. The study was designed to assess the time dependent effects with a total of 30 rats divided into 6 groups. Group 1(Control), Group 2 (Pain Only), Group 3 (Pain + 5mg

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Uahomo, Precious Ojo, and Joshua Charles Isirima. "Neuroprotective Effects of Bryophyllum pinnatum against Ketamine-Induced Neurotoxicity in Wistar Rats: Neurochemical, Oxidative Stress, and Histological Investigation." International Neuropsychiatric Disease Journal 21, no. 6 (2024): 19–40. http://dx.doi.org/10.9734/indj/2024/v21i6452.

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Background: This study evaluated the neuroprotective effects of Bryophyllum pinnatum (B. pinnatum) in ketamine-induced neurotoxicity in Wistar rats, focusing on neurochemical and oxidative stress markers, as well as histological changes in the hippocampus and cerebral cortex. Methods: Sixty male Wistar rats were divided into six groups. Group 1 received normal saline (2ml), Group 2 was administered ketamine (20mg/kg), and Group 3 received risperidone (0.5mg/kg). Groups 4, 5, and 6 were treated with B. pinnatum at 50mg/kg, 100mg/kg, and 200mg/kg, respectively for a duration of 21 days after ind

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Khooshbu, Pasha, and Imtiyaz Ansari. "A PHARMACOGNOSTICAL AND PHARMACOLOGICAL REVIEW ON BRYOPHYLLUM PINNATUM (PANPHUTI)." Asian Journal of Pharmaceutical and Clinical Research 12, no. 1 (2019): 34. http://dx.doi.org/10.22159/ajpcr.2018.v12i1.28988.

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Bryophyllum pinnatum is usually known as Panphuti which belong to family Crassulaceae growing widely in tropical Africa, tropical America, India, China, and Australia. It is a perennial herb grows 3–5 feet tall, fleshy dark green leaves that are distinctively scalloped and trimmed in red, and bell-like pendulous flowers. The plant contains various active compounds such as alkaloids, triterpenes, glycosides, flavonoids, steroids, bufadienolides, lipids, and organic acids. The pharmacological studies are reviewed and discussed, focusing on that different extracts from this plant have anti-inflam

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Khooshbu, Pasha, and Imtiyaz Ansari. "A PHARMACOGNOSTICAL AND PHARMACOLOGICAL REVIEW ON BRYOPHYLLUM PINNATUM (PANPHUTI)." Asian Journal of Pharmaceutical and Clinical Research 12, no. 1 (2019): 34. http://dx.doi.org/10.22159/ajpcr.2019.v12i1.28988.

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Bryophyllum pinnatum is usually known as Panphuti which belong to family Crassulaceae growing widely in tropical Africa, tropical America, India, China, and Australia. It is a perennial herb grows 3–5 feet tall, fleshy dark green leaves that are distinctively scalloped and trimmed in red, and bell-like pendulous flowers. The plant contains various active compounds such as alkaloids, triterpenes, glycosides, flavonoids, steroids, bufadienolides, lipids, and organic acids. The pharmacological studies are reviewed and discussed, focusing on that different extracts from this plant have anti-inflam

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Ankit, Subhash Kale, Surendra Patil Anita, and Madhukarrao Paikrao Hariprasad. "A modified TLC bioautographic technique for the detection of antilithiatic potential of therapeutic plants from Indigenous Ayurvedic System." Pharmaceutical Methods 8, no. 1 (2017): 01–04. https://doi.org/10.5281/zenodo.14854409.

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Introduction: Urolithiasis is the most painful disorder associated with formation of stone in the urinary system. In Indian Ayurvedic systems, medicinal plants are preferred as natural drug resources. In the present study aqueous extract of Bryophyllum pinnatum (L.), Tribulus terrestris (L.), Phyllanthus niruri (L.), Abutilon indicum (L.) and positive control tri-sodium citrates were used to investigate their antilithiatic potential in the modified dot blot assay. Methods: In the present study aqueous extract of all four plants in variable concentrations were tested for antilithiatic potential

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AGAKWU, Monica Ukungakpe, Gbenga Samson OGUNMEFUN, Hajara Oyiza YUSUF, Adaobi Yvonne ONMONYA, and John Olarewaju ADUNBI. "Assessing the Bioactivity of Bryophyllum pinnatum Leaves powder on Drosophila melanogaster: A Toxicological Study." Journal of Biochemistry and Molecular Biology 2, no. 1 (2024): 32–43. https://doi.org/10.36108/jbmb/4202.20.0140.

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Using Drosophila melanogaster as an experimental organism, this study examined the bioactivity and possible harmful consequences of Bryophyllum pinnatum leaves powder. In order to assess phenotypic differences among five filial generations (F1–F5), the leaves powder was added to culture media at different concentrations (1.0 g/g, 0.5 g/g, and 0.25 g/g). The leaves powder caused developmental abnormalities, such as apterous wings, small stature, and narrow abdomens as seen by phenotypic traits. Significant impacts of leaf powder concentration were shown by statistical studies, such as one-way A

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Yadav, Priyanka, Arun K. Mishra, and Harpreet Singh. "Characterization of the Bryophyllum pinnatum leaf's Active Component and It's Antidiarrheal Potential." Oriental Journal Of Chemistry 39, no. 3 (2023): 772–82. http://dx.doi.org/10.13005/ojc/390330.

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Diarrhea is a symptom experienced by nearly everyone, generally considered an increase in the volume, fluidity, and/or frequency of stools. Chronic diarrhea may affect ~5% of people in industrialized countries, and acute or chronic infectious diarrhea remains an important cause of morbidity in developing countries. The Crassulaceae family of plants includes the Bryophyllum pinnatum (Lam.) Oken plant, which is well renowned for its therapeutic properties. The main aim of the research is to assess the antidiarrheal property using Mgso4 induced diarrheal model and isolate an active compound. Both

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LOLA ADEOLA ADELAKIN, PONLE BAMIDELE FAKUNLE, DORCAS OLUBUNMI TAIWO-OLA, et al. "Bryophyllum pinnatum methanolic extract and flavonoid-rich fraction regulate antioxidant/neurotransmitter levels in MSG-induced rat neurotoxicity." World Journal of Advanced Research and Reviews 23, no. 2 (2024): 2711–24. http://dx.doi.org/10.30574/wjarr.2024.23.2.2575.

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Introduction: Bryophyllum pinnatum (B. pinnatum/BP), a medicinal plant known for its diverse pharmacological properties, has been traditionally used for treating various ailments. This study investigated its potential therapeutic effects against MSG-induced oxidative stress and neurotoxicity in Wistar rats, employing both in vivo and in-silico approaches. Methods: Forty-eight adult Wistar rats (n=48) were divided into six groups: control group, MSG group, and treatment groups receiving BP extract and B.pinnatum flavonoid-rich fractions. Biochemical markers such as LDH, MDA, CAT, GST, and AChE

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Kalita, Kangkan, Bhaswati Kashyap, Rosy Ahmed, et al. "Distribution, ethnomedicinal uses, phytochemical profile and pharmacological activities of Kalanchoe pinnata (Lam.) Pers.: a review." Journal of Bioresources 9, no. 2 (2022): 1–6. https://doi.org/10.5281/zenodo.8274802.

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<em>Kalanchoe pinnata</em> (Lam.) Pers. (Crassulaceae), also known as the "Life Plant", has been used in traditional medicine across various cultures for the treatment of numerous ailments such as wounds, respiratory infections, and kidney stones. In recent years, there has been growing interest in the scientific investigation of this plant to validate its traditional uses and to discover potential new therapeutic applications. This review summarizes the current status of traditional and ethnomedical utility, phytochemical profile, and established pharmacological activities of&n

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Ojeleye, Folashade, Theresa Isama, Olamide Oyekunle, Jessica John, Talatu Markus, and Ochuko Orakpoghenor. "Antibacterial Activity of the Combined Ethanolic Leaf Extracts of Corchurus olitorius and Bryophyllum pinnatum on Some Multi-drug Resistant Bacterial Isolates." Journal of Biological Research and Reviews 1, no. 1 (2024): 1. http://dx.doi.org/10.5455/jbrr.20240220124026.

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The surge in antibiotic resistance has led to an urgent need for alternative therapeutic strategies. This study investigated the antibacterial activity of the combined ethanolic leaf extracts of Corchurus olitorius and Bryophyllum pinnatum on some MDR bacterial isolates (Escherichia coli, Proteus mirabilis, Streptococcus pneumoniae, Salmonella typhi, and Pseudomonas aeruginosa). The ethanolic leaf extracts were prepared using standard procedures. Antibacterial sensitivity of the isolates were carried out using varying concentrations (200, 100, 50, and 25 mg/mL) of different C. olitorius to B.

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LOLA, ADEOLA ADELAKIN, BAMIDELE FAKUNLE PONLE, OLUBUNMI TAIWO-OLA DORCAS, et al. "Bryophyllum pinnatum methanolic extract and flavonoid-rich fraction regulate antioxidant/neurotransmitter levels in MSG-induced rat neurotoxicity." World Journal of Advanced Research and Reviews 23, no. 2 (2024): 2711–24. https://doi.org/10.5281/zenodo.14906882.

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<strong>Introduction</strong>: <em>Bryophyllum pinnatum </em>(<em>B. pinnatum</em>/BP), a medicinal plant known for its diverse pharmacological properties, has been traditionally used for treating various ailments. This study investigated its potential therapeutic effects against MSG-induced oxidative stress and neurotoxicity in Wistar rats, employing both in vivo and in-silico approaches. <strong>Methods</strong>: Forty-eight adult Wistar rats (n=48) were divided into six groups: control group, MSG group, and treatment groups receiving BP extract and <em>B.pinnatum</em> fl

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Souza, Maycon Douglas Araújo, Hellen Cris Araújo Souza, Edilanne Katrine Amparo Viana, et al. "An In silico Analysis Study of the Chemical Compounds from the Crassulaceous Plant Bryophyllum pinnatum (Lam.) Oken against the SARS-COV-2 Proteases." Journal of Advances in Medicine and Medical Research 35, no. 23 (2023): 69–91. http://dx.doi.org/10.9734/jammr/2023/v35i235284.

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Introduction: Acute severe respiratory syndrome SARS-COV-2, a member of the coronavirus family of enveloped RNA viruses, is the disease-causing agent of COVID-19. Research has been done on the active components of medicinal plants that have therapeutic promise. In this regard, the goal of this work was to investigate the anti-SARS-CoV-2 activity of compounds from the plant Bryophyllum pinnatum (Lam.) Oken. Materials and Methods: The methodology involved the selection of chemical constituents from the plant leaves in the Pubchem database, in addition to obtaining the protein structures of

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Chibuzor, Johnson V., Felix A. Onyegbule, Blessing Umeokoli, Blessing O. Oyedemi, and Eze I. Lucky. "Preliminary Phytochemical, Antioxidative and Antibacterial Screening of Selected Medicinal Plants for Possible use in the Treatment of Bacterial Diseases." Journal of Pharmaceutical Research International 36, no. 1 (2024): 38–60. http://dx.doi.org/10.9734/jpri/2024/v36i17495.

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Development of cheap and reliable diagnostics is pivotal in the control of infectious diseases. Currently, one of the best strategies to tackle infectious disease is the use of natural products from plant origin, due to the perception that long term use of western medicine induces severe complications and also to stop the prevalence of antibacterial infection. This study aims at substantiating the traditional use of selected medicinal plants with antibacterial claim for possible lead for the development of more potent drugs in the treatment of bacterial infections. The preliminary phytochemica

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Martins Fernandes Pereira, Kassia, Ana Calheiros de Carvalho, Thiago André Moura Veiga, et al. "The psychoactive effects of Bryophyllum pinnatum (Lam.) Oken leaves in young zebrafish." PLOS ONE 17, no. 3 (2022): e0264987. http://dx.doi.org/10.1371/journal.pone.0264987.

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Bryophyllum pinnatum (Lam.) Oken (BP) is a plant that is used worldwide to treat inflammation, infections, anxiety, restlessness, and sleep disorders. While it is known that BP leaves are rich in flavonoids, the extent of the beneficial and toxic effects of its crude extracts remains unclear. Although some neurobehavioral studies using leaf extracts have been conducted, none has examined the effects of water-extracted leaf samples. The zebrafish is a powerful animal model used to gain insights into the efficacy and toxicity profiles of this plant due to its high fecundity, external development

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Rao, Alka, Shikha Kumari, Jitender Singh Laura, and Geeta Dhania. "Qualitative Phytochemical Screening of Medicinal Plants Using Different Solvent Extracts." Oriental Journal Of Chemistry 39, no. 3 (2023): 621–26. http://dx.doi.org/10.13005/ojc/390312.

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Medicinal plants are rich in bioactive components that are utilized to treat various human ailments. They are crucial to healing as well. Phytochemical constituents are responsible for the medicinal activity of plant species. Phytochemical screening is an important step in identifying bioactive compounds present in particular medicinal plants. Hence, in this present work, phytochemical screening of leaf extract of some traditional medicinal plants, namely Cannabis sativa, Ricinus communis, and Bryophyllum pinnatum was carried out. The solvent extracts of the leaves of respective plants were pr

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Perera, HKI, and HASK Ranasinghe. "A simple method to detect plant based inhibitors of glycation induced protein cross-linking." Asian Journal of Medical Sciences 6, no. 1 (2014): 28–33. http://dx.doi.org/10.3126/ajms.v6i1.10181.

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Background: Glycation induced cross-linking of proteins are associated with chronic diabetic complications. Inhibition of protein glycation is one of the therapeutic approaches to prevent the progression of diabetic complications. Objective: Objective of this study was to establish a simple method to identify medicinal plants which can inhibit glycation induced protein cross-linking. Methods: Lysozyme was incubated at 37°C up to 4 weeks with different concentrations of glucose, fructose and ribose in sodium phosphate buffer (pH 7.4). Appropriate controls and blanks were carried out. Aminoguani

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U, Olayinka B., Babatunde M. O, Ogundare G. O, et al. "EVALUATION OF PROXIMATE, PHYTOCHEMICAL AND MINERAL COMPOSITIONS OF LEAF, STEM AND ROOT OF BRYOPHYLLUM PINNATUM AND PHYLLANTHUS AMARUS." Science Journal of University of Zakho 12, no. 3 (2024): 388–95. http://dx.doi.org/10.25271/sjuoz.2024.12.3.1338.

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Bryophyllum pinnatum and Phyllanthus amarus are plants that have been established to contain bioactive substances for various therapeutic advantages, most importantly their leaves. Information on the other parts of the plant, such as stem and root, is scanty in literature; hence, there is a need to compare the various parts of the plants in terms of proximate composition, phytochemicals, and mineral elements. The results showed that the two plants had the highest amount of carbohydrate (62.09 - 63.98%) and followed in decreasing order of magnitude by protein (16.04 - 17.50%), moisture (10.05 -

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Emeka, Promise Madu. "In-vitro studies of Bryophyllum pinnatum Crude Extract on Blood Coagulation Indices: An Investigation on its Traditional Medicine Use." Pharmacognosy Research 13, no. 4 (2021): 268–73. http://dx.doi.org/10.5530/pres.13.4.21.

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Simões-Wüst, Ana Paula, Olav Lapaire, Irene Hösli, et al. "Two Randomised Clinical Trials on the Use of Bryophyllum pinnatum in Preterm Labour: Results after Early Discontinuation." Complementary Medicine Research 25, no. 4 (2018): 269–73. http://dx.doi.org/10.1159/000487431.

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Erhenhi, A. H., T. C. Atisele, C. Ogwezy, et al. "Ethno-botanical Utilization of Selected Medicinal Plant Species in Edo and Delta States, Nigeria." Sokoto Journal of Medical Laboratory Science 7, no. 2 (2022): 40–47. http://dx.doi.org/10.4314/sokjmls.v7i2.5.

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The ethno-botanical research results were obtained in five communities (Umuagwu, Ogume, Abbi, Kokori and Ekpan) in Delta State and one community (Arue) Esan North East, in Edo State. Acalypha wilkesiana was used for the treatment of high blood pressure by the People of Umuagwu Community, Asaba, Delta State, use of Sida acuta Burm. f. for the treatment of loss of appetite, digestion problem, tuberculosis and general health by Ogume People, Delta State, the use of Aspilia africana (Pers) C.D. for ulcer dressing and wound by the people of Abbi, Delta State, use of Bryophyllum pinnatum for the tre

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Cha, Jasmine, Elim Choi, Jessica Yi, et al. "Abstract 2540: Modulation of apoptosis in pancreatic adenocarcinoma BxPC-3 cells and ductal carcinoma PANC-1 cells by aqueous extract of Bryophyllum pinnatum." Cancer Research 83, no. 7_Supplement (2023): 2540. http://dx.doi.org/10.1158/1538-7445.am2023-2540.

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Abstract Bryophyllum pinnatum (BP) has been widely used in tropical regions as traditional medicine. It is reported to have antioxidant, immunomodulatory, antidiabetic, anti-inflammatory, antihypertensive, wound healing, cytotoxic, and antitumor-promoting activities. Its major secondary metabolites include bufadienolides, flavonoids, triterpenes, and steroids. Pancreatic cancer is usually symptom-free during development and is advanced by the time of diagnosis with a poor prognosis. BxPC-3 is a pancreatic adenocarcinoma cell derived from a 61-year-old female with adenocarcinoma while PANC-1 is

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Ghasi, S. "Assessment of the medical benefit in the folkloric use of Bryophyllum Pinnatum leaf among the Igbos of Nigeria for the treatment of hypertension." African Journal of Pharmacy and Pharmacology 5, no. 1 (2009): 83–92. http://dx.doi.org/10.5897/ajpp10.309.

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Umarudeen, Ajibola Monisola, Mohammed Garba Magaji, Ferhat Khan, and Abdulhakim Abubakar. "Acute Antidepressant Activity Investigation of Selected African Medicinal Plants in Mice: A Preliminary Study." European Journal of Pharmaceutical Research 3, no. 5 (2023): 1–6. http://dx.doi.org/10.24018/ejpharma.2023.3.5.66.

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The therapeutic gap arising from high global incidence of depressive disorders and the efficacy and toxicity shortcomings of existing antidepressant drugs indicate a need to further search the plant kingdom with the goal of discovering novel antidepressant pharmacotherapeutic agents. Crude 50% ethanol Terminalia catappa (CETC), Tapinanthus dodoneifolius (CETD) and Bryophyllum pinnatum (CEBP) leaf extracts were investigated for their acute antidepressant activity on the forced swim (FST) and tail suspension (TST) tests. Groups of mice (n = 6) were each exposed to the tests 1 hour following oral

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Campilan, Joni Rey, Marigold C. Tumamac, and Emma L. Dorado. "Quantitative Ethnobotanical Study, Phytochemical Screening and Antibacterial Assay of Ethnomedicinal Plants of T’boli In Lemsnolon, Tboli, South Cotabato." International Journal of Pharmacology, Phytochemistry and Ethnomedicine 13 (May 2019): 45–61. http://dx.doi.org/10.18052/www.scipress.com/ijppe.13.45.

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Tbolis in Lemsnolon, Tboli, South Cotabato are one of the ethnic groups in the Philippines serving as repository of novel knowledge on ethnomedicine. On July 2014, a research was conducted among Tboli tribe in Lemsnolon to document the local knowledge on ethnomedicinal plants before environmental and cultural changes deplete the resources. Selected important ethnomedicinal plants were quantified through Relative Frequency Citation and Use Value. Selected important medicinal plants were screened for phytochemical constituents, and their antibacterial property was determined through paper disc d

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Alam, Md Sah, M. Mahfuzur Rahman, Mohammed Kamal Hossain, and Tusher Kumer Ray. "Medicinal plants used by the tribal communities of Thanchi Upazila in Bandarban Hill District, Bangladesh." Asian Journal of Medical and Biological Research 8, no. 2 (2022): 123–40. http://dx.doi.org/10.3329/ajmbr.v8i2.60336.

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Medicinal plants play in an important role in the primary health care system. The paper deals with the indigenous knowledge related to ethnomedicinal knowledge and plant parts application for curing various ailments by the ethnic community of Thanchi Upazila of Bandarban Hill District. Semi-structured questionnaires, interviews, group discussions, and specific plant sample collection were done from July 2019 to December 2021 to procure ethno-medicinal data from local herbalists and elderly villagers for this study and from the forest areas. A total of 129 plant species under 110 genera and 63

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Zurfluh, Leonie, Marialuigia Giovannini Spinelli, Cornelia Betschart, and Ana Paula Simões-Wüst. "Repurposing of Bryophyllum pinnatum for dysmenorrhea treatment: a systematic scoping review and case series." Frontiers in Pharmacology 14 (December 1, 2023). http://dx.doi.org/10.3389/fphar.2023.1292919.

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Dysmenorrhea affects women throughout their reproductive years but there has been a lack of effective and well-tolerated treatment options. Pain symptoms mainly result from inflammatory processes and increased contractile activity in the myometrium. The reported use of Bryophyllum pinnatum preparations against inflammation and pain in ethnomedicine as well as current pharmacological data on their inhibition of myometrial contractility led us to hypothesize that this medicinal plant might be a new treatment option for dysmenorrhea. In the first part of the present work, clinical, in vivo, and i

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Mac-Kalunta, O. M., A. A. Ahamefula, C. Odii, and B. Ibe. "COMPARATIVE STUDIES OF THE YIELD AND CHEMICAL CONSTITUENTS OF Bryophyllumpinnatum BY COLD MERCERATION AND SOHXLET EXTRACTION METHODS." Journal of Chemical Society of Nigeria 47, no. 4 (2022). http://dx.doi.org/10.46602/jcsn.v47i4.788.

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Bryophyllum pinnatum belongs to the family crassulaceae and is widely used in traditional medicine, especially in tropical areas. In the present study, extract yield and phytochemical constituents of chloroform extracts of Bryophyllum pinnatum leave prepared using two most commonly used extraction techniques known as cold maceration, and soxhlet extraction was investigated. Analysis using gas chromatography and mass spectrometry (GC/MS) was done on the extracted materials. The extract produced by the cold maceration method yielded ten (10) compounds, whereas the extract produced by the soxhlet

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Christy, Akanji Olufunke, Idu MacDonald, and Ovuakporie-Uvo Oghale. "Ethnomedicinal Survey Of Indigenous Flora For The Management Of Cancer In South-Western, Nigeria." Current Traditional Medicine 06 (February 20, 2020). http://dx.doi.org/10.2174/2215083806666200220123521.

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Background: Nigeria as a multi-ethnic and multi-regional nation is blessed with a great diversity of traditional approaches to common diseases of mankind. Thus, ethnomedicinal surveys are key in reconciling long existing therapeutic approaches as bedrocks for drug discovery to ailing diseases of man today. Objective of Study: An ethnomedicinal survey was carried out in Ondo, Ekiti, Ogun, Osun and Oyo States of South-western region of Nigeria where mostly the Yoruba people live; to identify and document medicinal plants used in the management of cancer. Methods: Herbalists, traditional healers,

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