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Journal articles on the topic 'Buccal Tablets'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Webster, Lynn R. "Fentanyl buccal tablets." Expert Opinion on Investigational Drugs 15, no. 11 (2006): 1469–73. http://dx.doi.org/10.1517/13543784.15.11.1469.

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2

GUPTA, SANJAY KUMAR, Sradhanjali Patra, and Syed Adnan Akber. "FORMULATION DEVELOPMENT AND IN VITRO EVALUATION OF ALENDRONATE BUCCAL TABLETS." Journal of Drug Delivery and Therapeutics 9, no. 4-s (2019): 363–69. http://dx.doi.org/10.22270/jddt.v9i4-s.3253.

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The aim of this work was to develop a mucoadhesive buccal tablet for the buccal delivery of the alendronate via buccal mucosa. Buccal tablets of alendronate are designed to release drug at mucosal site for extended period of time without wash out of drug by saliva. Alendronate sodium is a bisphosphonates which has antiresorptive effect which is implicated in the prophylaxis and treatment of osteoporosis. Sodium alginate, ethyl cellulose and carbopol were selected as mucoadhesive polymers on the basis of their matrix forming properties. The objective of the study is to improve the bioavailabili

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3

Gawai, Nitin, and Zahid Zaheer. "FORMUALTION AND DEVELOPMENT OF MUCOADHESIVE SUSTAINED RELEASE BUCCAL TABLETS AND PATCHES OF 5-FLUOROURACIL USING DIFFERENT POLYMERS." Asian Journal of Pharmaceutical and Clinical Research 11, no. 5 (2018): 174. http://dx.doi.org/10.22159/ajpcr.2018.v11i5.20241.

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Objective: The present research study was undertaken to formulate mucoadhesive sustained release buccal tablets and patches of 5-fluorouracil (5-FU).Method: For the research experiment work design expert software version 10, stat-ease, Inc. has been used. A 32 full factorial design was selected for the formulation of the buccal tablet as well as buccal patches. In this research work, formulated tablets and patches using different polymers such as carbopol 974p, polyvinylpyrrolidone-K 30, sodium deoxycholate, microcrystalline cellulose, and polyvinyl alcohol. An after formulation of batches for

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Singh, Shubham, Anand Chaurasia, Naveen Gupta, and Dharmendra Singh Rajput. "Effect of Formulation Parameters on Enalapril Maleate Mucoadhesive Buccal Tablet Using Quality by Design (QbD) Approach." Chinese Journal of Applied Physiology 40 (2024): e20240003. http://dx.doi.org/10.62958/j.cjap.2024.003.

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The buccal route has great prospects and possible benefits for the administration of drugs systemically. The present study involves designing, developing and optimising the buccal tablet formulation of Enalapril Maleate (EM) by using the QbD approach. We prepared the EM buccal tablets using the dry granulation method. In the QTPP profile, the CQAs for EM buccal tablets are Mucoadhesive strength, swelling index and drug release (dependent variables); the CMAs identified for EM buccal tablets were Carbopol 934P, HPMC-K100M and chitosan (independent variables). Diluent quantity, blending time and

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Omer, Mohammed, and S. M. Shahidulla. "Formulation and Evaluation of Mucoadhesive Bilayered Buccal Tablet of Ziprasidone Hydrochloride." Journal of Drug Delivery and Therapeutics 12, no. 5-S (2022): 174–80. http://dx.doi.org/10.22270/jddt.v12i5-s.5757.

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The present project was carried out to formulate and evaluate the mucoadhesive bilayered buccal tablet of Ziprasidone Hcl. Ziprasidone HCl is an antipsychotic agent with half-life of about 2hrs and shows extensive metabolism i.e the drug concentration is < 5% after elimination in the body. The formulations (F1 to F6) were developed which comprises of polymers such as Hydroxypropyl methyl cellulose (HPMC K-15), Polyvinyl pyrollidine (PVP K-30) in various concentrations along with carbopol to achieve the desired characteristics. Mucoadhesive bilayered buccal tablets were fabricated with the a

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Durfee, Steven, John Messina, and Raj Khankari. "Fentanyl Effervescent Buccal Tablets." American Journal of Drug Delivery 4, no. 1 (2006): 1–5. http://dx.doi.org/10.2165/00137696-200604010-00001.

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7

Samanthula, Kumara Swamy, Agaiah Goud Bairi, and CB Mahendra Kumar. "Muco-adhesive buccal tablets of candesartan cilexetil for oral delivery: preparation, in-vitro and ex-vivo evaluation." Journal of Drug Delivery and Therapeutics 11, no. 1-s (2021): 35–42. http://dx.doi.org/10.22270/jddt.v11i1-s.4547.

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Candesartan cilexetil (CC) is an angiotensin II-receptor blocker (ARB). The antihypertensive effect of CC 4-16 mg/day was as great as that of other once-daily dosage regimens. Candesartan cilexetil has high first-pass metabolism and low oral bioavailability. The bioavailability of such drugs may be significantly improved if delivered through the buccal route; hence mucosal delivery is one of the alternative methods of systemic drug delivery. This study’s objective was to develop mucoadhesive buccal tablets of candesartan cilexetil using carbopol-934P, hydroxyl propyl methyl cellulose (HPMC), E

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Kaundal, Ankaj, Pravin Kumar, Rajendra Awasthi, and Giriraj T. Kulkarni. "Development of Mucoadhesive Buccal Drug Delivery System of Propranolol Hydrochloride Using Aster ericoides Mucilage." Drug Delivery Letters 10, no. 2 (2020): 133–48. http://dx.doi.org/10.2174/2210303109666191010164201.

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Aim: The study was aimed to develop mucoadhesive buccal tablets using Aster ericoides leaves mucilage. Background : Mucilages are naturally occurring high-molecular-weight polyuronides, which have been extensively studied for their application in different pharmaceutical dosage forms. Objective: The objective of the present research was to establish the mucilage isolated from the leaves of Aster ericoides as an excipient for the formulation of the mucoadhesive buccal tablet. Method: The mucilage was isolated from the leaves of Aster ericoides by maceration, precipitated with acetone and charac

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Rachana, Sarawade1 Deepak Rathod2. "Formulation And Evaluation of Novel Drug Delivery System Containing Anti Parkinson's Agent." International Journal of Pharmaceutical Sciences 2, no. 12 (2024): 1530–55. https://doi.org/10.5281/zenodo.14406680.

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Introduction : This study explores the use of buccal administration as a potential route for delivering Levodopa (LD) in the treatment of Parkinson's disease (PD). Parkinson's disease is a neurodegenerative disease that affects dopaminergic neurons, leading to a deficiency of dopamine. The current treatment of choice is levodopa, but it has low oral bioavailability and poor brain uptake. The methodology involves the formulation of buccal mucoadhesive tablets that attach to the buccal mucosa. The study highlights the advantages of the formulation by increasing bioavailability and bypassing of g

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Nishigandha, Pandurang Gite1* Vinayak Munde2. "Formulation And Evaluation Of Mucoadhesive Buccal Tablet Of Favipiravir." International Journal in Pharmaceutical Sciences 2, no. 8 (2024): 3733–54. https://doi.org/10.5281/zenodo.13371490.

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This research work investigates the formulation and evaluation of mucoadhesive buccal tablets containing Favipiravir, an antiviral medication with proven efficacy against various RNA viruses, including influenza and certain strains of coronaviruses. The objective of this study is to develop a novel drug delivery system that enhances the bioavailability and therapeutic efficacy of Favipiravir through buccal administration, thereby addressing the limitations associated with conventional oral dosage forms. The formulation development phase involves the selection of suitable mucoadhesive polymers

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11

Nerkar, Pankaj P., Hitendra Mahajan, Pradum Ige, and Rima Solanki. "Development and Evaluation of Chia Seed Mucilage-based Buccal Mucoadhesive, Sustained Release Tablet of Venlafaxine." International Journal of Pharmaceutical Sciences and Nanotechnology 9, no. 6 (2016): 3536–43. http://dx.doi.org/10.37285/ijpsn.2016.9.6.4.

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In the present study we performed extraction of chia seed mucilage, formulation, and evaluation of buccal mucoadhesive tablet containing extracted mucialge and venlafaxine, an commonly used antidepressant. Tablets were prepared using a formulation mixture of calcium phosphate, talc and magnesium stearate. Tablets were prepared by experimental factorial design software, using central composite design; where the concentration of chia seeds mucilage and that of magnesium stearates were independent variables. Drug release, friability and mucoadhesive strength were studied as dependent variables. T

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Mohammad, Azmath Hussain*1 Dr. Sreenivas Rao Mande1 Dr. G. Kumara Swamy1 Dr. D. Praveen Kumar2 Dr. J. Kumar Raja2. "Formulation Development and Evaluation of Clotrimazole Buccal Tablets." International Journal of Pharmaceutical Sciences 2, no. 12 (2024): 1962–68. https://doi.org/10.5281/zenodo.14461557.

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The current study's objective is to develop and assess the Clotrimazole Buccal Tablets. Clotrimazole buccal tablets are made with locust bean gum, Methocel K4M, and Methocel K15M. A buccal medication is administered between the gums and the cheek's inner lining. We refer to this region as the buccal pouch. When a medication needs to start working right away or is intended for a child, especially one who is unconscious, it is typically administered in the buccal region. Buccal tablets' benefits include: First pass: Because the liver is avoided, medications have a better bioavailability. Fast ab

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Navamanisubramanian, Raja, Raghunandan Nerella, and Shanmuganathan Seetharaman. "Pharmacokinetic Investigation to Study the In Vivo Bioavailability of Thiolated Chitosan Based Repaglinide Buccal Tablets." Pharmaceutical Sciences 26, no. 4 (2020): 414–22. http://dx.doi.org/10.34172/ps.2020.62.

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Background: Repaglinide (REP) is an antihyperglycemic drug having low bioavailability due to its extensive first-pass metabolism. The present study aimed to develop and pharmacokinetic investigte the thiolated chitosan (TC) based buccal tablets of REP for improved bioavailability. Methods: TC was prepared by conjugation of L-cysteine with chitosan. The amount of free thiol groups present in TC was determined by UV-spectrophotometry using Ellman’s reagent. TC based REP buccal tablets were prepared by two layers co-compression method and characterized for in vitro and ex vivo parameters. The in

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14

Shirsand, S. B., G. V. Wadageri, S. A. Raju, and Gopikrishna Kolli. "Formulation and In Vivo Evaluation of Mucoadhesive Buccal Tablets of Carvedilol." International Journal of Pharmaceutical Sciences and Nanotechnology 6, no. 3 (2013): 2164–71. http://dx.doi.org/10.37285/ijpsn.2013.6.3.8.

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In present study we studied the feasibility of preparing mucoadhesive buccal delivery systems containing carvedilol to improve drug residence time on buccal mucosa and drug dissolution rate, to circumvent the first-pass metabolism and quick drug entry into the systemic circulation. Bilayer buccal tablets of carvedilol prepared using controlled release and mucoadhesive polymers (hydroxypropyl methylcellulose 15 cps, 50 cps, K4M and Carbopol 934p) along with impermeable backing layer (ethyl cellulose). 15 formulations were developed with varying concentrations of polymers. The designed tablets w

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Ganesh, Nayak1* Akshay Killekar2 Krishnananda Kamath K.1 A. R. Shabaraya1 Viresh Chandur1. "Formulation And Evaluation of a Bilayer Mucoadhesive Buccal Drug Delivery System for Carvedilol Nanoparticles." International Journal of Pharmaceutical Sciences 2, no. 12 (2024): 54–62. https://doi.org/10.5281/zenodo.14254155.

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The main objective of this study was to formulate carvedilol nanoparticles into mucoadhesive bilayer tablets and evaluate the nanoparticle-loaded formulation. This approach aims to address the challenges of low solubility, poor bioavailability, and first-pass metabolism associated with carvedilol when administered in conventional oral dosage forms. Carvedilol nanoparticles were prepared using the nanoprecipitation method, as described in Ganesh R. Nayak et al. (Int. J. of Pharm. Sci., 2024, Vol. 2, Issue 7, 2010-2018). Bilayer buccal tablets were then prepared by direct compression and evaluat

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Mayur, aware, Gondkar Sheetal, and Bachhav Rishikesh. "Formulation And In-vitro Evaluation Of Bilayer Tablets Of Sitagliptin Phosphate." INTERNATIONAL JOURNAL IN PHARMACEUTICAL SCIENCES 1, no. 1 (2021): 49–61. https://doi.org/10.5281/zenodo.5778984.

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The aim of this work was to plan mucoadhesive bilayered buccal tablets of Sitagliptin Phosphate. Sitagliptin Phosphate is the phosphate salt type of sitagliptin, an orally accessible, serious, beta-amino acid-derived inhibitor of dipeptidyl peptidase 4 (DDP4) with hypoglycemic movement. Sitagliptin might cause an expanded danger in the advancement of pancreatitis. Mucoadhesive polymers like thickener and guar gum alongside methyl crystalline cellulose were utilized for the development of mucoadhesive bilayered tablets. The upgraded plan followed Non-Fickian discharge system. The rate relative

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Peddapalli, Himabindu, Vasudha Bakshi, and Narender Boggula. "FORMULATION, IN VITRO AND EX VIVO CHARACTERIZATION OF MUCOADHESIVE BUCCAL TABLETS FOR ANTIHYPERTENSIVE DRUG." Asian Journal of Pharmaceutical and Clinical Research 11, no. 8 (2018): 402. http://dx.doi.org/10.22159/ajpcr.2018.v11i8.26126.

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Objective: Olmesartan belongs to a class of angiotensin II receptor blockers. It is used in the treatment of hypertension. However, it undergoes extensive hepatic first-pass metabolism, resulting in low oral bioavailability is about 26%. The aim of this study was to prepare and evaluate the mucoadhesive buccal tablets of olmesartan with a goal to increase the bioavailability and improve the patient compliance.Methods: Mucoadhesive buccal tablets were prepared by a direct compression technique using mucoadhesive polymers such as hydroxypropyl methylcellulose (HPMC K4M), sodium carboxymethylcell

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18

Venkatesh, D. Nagasamy, Raman Rajeshkumar, and Roan Ngoc Anh Huy. "Formulation Development and In Vitro Evaluation of Buccal Tablets of Ramipril." Materials Science Forum 987 (April 2020): 83–87. http://dx.doi.org/10.4028/www.scientific.net/msf.987.83.

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The main objective of the present investigation was to develop buccal tablets of ramipril, to bypass the first pass metabolism and to improve its oral bioavailability. Ramipril, an ACE inhibitor used in the treatment of hypertension undergoes extensive first pass metabolism and about 25% of the drug reaches the systemic circulation. A unidirectional, bilayered mucoadhesive tablet of ramipril was prepared using HPMC as polymer by direct compression technique. Initially, a backing layer was made by using ethyl cellulose, onto which the drug containing layer as placed and recompressed to get a bi

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Singh, Sudarshan, Dharmesh Savaliya, Suresh Shah D., and Sunil Bothara B. "Development and In vivo Bioavailability Evaluation of Sumatriptan Succinate Buccal Tablets." International Journal of Pharmaceutical Sciences and Nanotechnology 7, no. 2 (2014): 2477–86. http://dx.doi.org/10.37285/ijpsn.2014.7.2.9.

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In the present investigation an attempt has made to design mucoadhesive buccal tablets of sumatriptan succinate to improve its bioavailability. The mucoadhesive buccal tablets were prepared by wet granulation procedure using different concentration of polycarbophil and hydroxy propyl methyl cellulose K4M alone. Compatibility study of drug and polymer were performed by Fourier transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC). Precompression property of sumatriptan succinate was evaluated to check the suitability of compression method. Postcompressional paramete

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20

Banala, Nagaraj, Himabindu Peddapalli, Narendar Dudhipala, and Krishna Mohan Chinnala. "Transmucosal Delivery of Duloxetine Hydrochloride for Prolonged Release: Preparation, in vitro, ex vivo Characteri-zation and in vitro-ex vivo Correlation." International Journal of Pharmaceutical Sciences and Nanotechnology 11, no. 5 (2018): 4249–58. http://dx.doi.org/10.37285/ijpsn.2018.11.5.5.

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Duloxetine hydrochloride is a selective serotonin and nor adrenaline reuptake inhibitor. It is used in the treatment of depression, diabetic peripheral neuropathic pain and in moderate to severe stress urinary incontinence in women. However, it undergoes extensive hepatic first-pass metabolism and susceptible to undergo degradation in acidic environment of stomach, which results in the poor bioavailability. The objective of the present study was to develop and evaluate the mucoadhesive buccal tablets (transmucosal delivery) of duloxetine hydrochloride with a goal of to increase the bioavailabi

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Undru Purnima, T.K.V. Kesav Rao, and Raj Khiani. "Formulation development and evaluation of omeprazole buccal tablets." International Journal of Research in Pharmacology & Pharmacotherapeutics 12, no. 3 (2023): 185–96. http://dx.doi.org/10.61096/ijrpp.v12.iss3.2023.185-196.

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Omeprazole is a medication used in the treatment of gastroesophageal reflux disease (GERD), peptic ulcer disease, and Zollinger–Ellison syndrome. It is also used to prevent upper gastrointestinal bleeding in people who are at high risk. The Mucoadhesive buccal tablets were prepared by direct compression method using Sodium Alginate, HPMC K4M and SCMC as mucoadhesive polymer. The compatibility studies of drug and excipients were performed by FT-IR spectroscopy. After examining the flow properties of the powder blends the results are found to be within prescribed limits and indicated good flowin

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K., Ramanji Reddy* Dr. S. Jaya M.Kavya Dr. Chandaka Madhu. "FORMULATION AND EVALUATION OF MUCOADHESIVE BUCCAL TABLETS OF KETOROLAC TROMETHAMINE." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 02 (2018): 938–51. https://doi.org/10.5281/zenodo.1181848.

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Among the various routes of drug delivery, the oral route is perhaps the most preferred by patients and clinicians alike. Ketorolac is currently administered intramuscularly (30 mg) and orally as conventional tablet (10 mg) for short-term management of post-operative pain and moderate to severe pain. It is a non-steroidal antiinflammatory cyclooxygenase inhibitor. It acts by inhibiting the synthesis of prostaglandins. The major side effects of Ketorolac are gastric mucosal erosions, ulcers and gastric bleeding. The aim of this study was to prepare a new mucoadhesive tablet formulation of Ketor

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*Rohan, Chankhore, Vinod Chaware Prof., Shivshankar D. Mhaske Dr., P. Walukar Vrushali, Gawande Devyani, and Tejas J. Sharma Prof. "FORMULATION & EVALUATION OF HERBAL BUCCAL TABLET." World Journal of Advance Pharmaceutical Sciences 2, no. 1 (2025): 134–58. https://doi.org/10.5281/zenodo.15563453.

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This project was aimed to formulate and characterize mucoadhesive buccal tablets ofaceclofenac, utilizing different proportions of three polymers carbopol 934,hydroxypropyl methylcellulose, and sodium carboxy methyl cellulose. Twelvebatches of buccoadhesive aceclofenac were prepared by the direct compressionmethod. The compressed tablets were then evaluated for physicochemical parameterssuch as hardness, thickness, weight variation, drug content, friability, swelling index,surface pH, and ex vivo mucoadhesion. In vitro dissolution test was conducted for 12h according to Indian Pharmacopeia 201

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FALAHI, ASA, and DEWI RASHATI. "OPTIMASI FORMULA TABLET BUKAL MUKOADHESIVE GLIBENKLAMID MENGGUNAKAN MATRIKS CMC NA SERTA ASAM OLEAT SEBAGAI ENHANCHER." JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER 4, no. 1 (2021): 38–43. http://dx.doi.org/10.53864/jifakfar.v4i1.49.

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Glibenclamide is a sulfonylurea class of antidiabetic drugs that works by stimulating insulin secretion in the pancreas so that it is effective only when the β-cells of the pancreas can still produce. The glibenclamide dosage form that is on the market is a conventional oral tablet which has various disadvantages in terms of pharmacokinetics. Based on this, it is necessary to develop a more effective drug delivery system for glibenclamide in order to avoid first-pass metabolism so as to increase the bioavailability of glibenclamide, namely by making mucoadhesive buccal tablets. This glibenclam

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Wathore, Sandeep Ashokrao. "Formulation and In-Vitro Evaluation of Buclizine Buccoadhesive Tablets." Journal of Drug Delivery and Therapeutics 9, no. 4-A (2019): 137–44. http://dx.doi.org/10.22270/jddt.v9i4-a.3430.

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Buclizine is an antihistamine that is used to treat motions sickness, especially to prevent and treat symptoms such as abdominal pain, dizziness, nausea, vomiting, headaches, etc. It may also be used either alone or in a combination with other medicines for the treatment of hay fever and other allergic conditions. These dosages form make close contact with buccal mucosa, avoid first- pass metabolism, increase absorption and patient compliance, results in an enhanced drug bioavailability. Buccal adhesive tablets were prepared by direct compression. Carbopol 940 and Sodium Alginate was used in d

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Sachin, Jagdale, Panbude Aishwarya, and Navasare Priya. "Development, Characterization and Optimization of Mucoadhesive Tablet for Buccal Delivery of Domperidone." Drug Delivery Letters 9, no. 1 (2019): 37–49. http://dx.doi.org/10.2174/2210303108666181108120840.

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Background and Objective: Upon oral administration domeperidone is rapidly absorbed, but subjected to the first pass effect which lowers systemic bioavailability to 15%. Mucoadhesive tablet can remain attached to buccal mucosa and becomes capable of bypassing hepatic first-pass metabolism to improve absorption directly into systemic circulation. The present research work was carried with an aim to develop, evaluate and optimize mucoadhesive tablet containing domperidone (DOME) for buccal delivery using different bio-adhesive polymeric combinations. </P><P> Methods: The buccal table

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LAHIRI, AVIJIT. "Buccal Nitroglycerin Tablets in Heart Failure." Annals of Internal Medicine 105, no. 1 (1986): 141. http://dx.doi.org/10.7326/0003-4819-105-1-141_1.

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28

LOWRY, FRAN. "Fentanyl Buccal Tablets Relieve Breakthrough Pain." Family Practice News 38, no. 6 (2008): 45. http://dx.doi.org/10.1016/s0300-7073(08)70410-9.

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U.S. Food and Drug Administration. "Safety Alert for Fentanyl Buccal Tablets." Journal of Pain & Palliative Care Pharmacotherapy 22, no. 1 (2008): 47. http://dx.doi.org/10.1080/15360280801989401.

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Thakare, Eknath B., Prashant S. Malpure, Avish D. Maru, and Yashpal M. More. "Formulation and Evaluation of Mucoadhesive Buccal Tablet of Repaglinide." Journal of Drug Delivery and Therapeutics 9, no. 4-A (2019): 415–24. http://dx.doi.org/10.22270/jddt.v9i4-a.3488.

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The aim of present investigation was formulation and evaluation of mucoadhesive buccal tablet of Repaglinide to study the effect of different polymers on release profile of drug for prolonged release. In this study mucoadhesive buccal tablet were prepared by direct compression method. Various rheological characteristics of the powder bed like bulk density, compressibility index, and angle of repose were evaluated and studied. Mucoadhesive buccal tablets were compressed on a 8 station mini press using 10 mm flat faced punches and were all assessed for weight variation, hardness, thickness, perc

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Ayush Rajesh Ghosalkar, Dr. Rajani Shettigar, and Swapnil D Phalak. "Buccal Mucoadhesive Tablets: A Comprehensive Review on Formulation, Mechanism, and Clinical Applications." International Journal of Scientific Research in Science and Technology 12, no. 2 (2025): 540–57. https://doi.org/10.32628/ijsrst251222591.

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Buccal mucoadhesive tablets have gained significant attention as an advanced drug delivery system due to their capacity to enhance bioavailability, extend drug release, and improve patient compliance. These tablets adhere to the buccal mucosa, facilitating direct absorption into the bloodstream while bypassing first-pass metabolism and enzymatic breakdown. This method is especially advantageous for drugs with limited oral bioavailability or those that need controlled release. The formulation of buccal mucoadhesive tablets involves carefully choosing polymers, excipients, and bio-adhesive agent

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Rahim, Mulani* Tushar Kore Shrirang Kharmate Saurabh Joshi Dipak Phalle Mrudula More Mrunal Mali Pratibha Shingade. "Mouth Dissolving Films: A Novel Approach to Oral Drug Delivery and Patient Compliance." International Journal of Pharmaceutical Sciences 3, no. 3 (2025): 128–32. https://doi.org/10.5281/zenodo.14960719.

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Since mouth dissolving films are more convenient and user-friendly than other dosage forms like buccal tablets, sublingual tablets, and orally disintegrating tablets, they represent a novel approach to oral drug delivery systems. As a result, many pharmaceutical industries are becoming interested in mouth dissolving films. Due to the strong vascularization of the oral buccal mucosa, medications can be absorbed straight and enter the bloodstream without first-pass hepatic processing. Adequate flexibility, elasticity, softness, resistance to breaking, minimal disintegration time, and flavor comp

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Tikait, Aditi Vijay, Vikrant P. Wankhade, Yukta Mhaske, Sandeep C. Atram, Nishan N. Bobade, and Pande S. D. "Formulation and Evaluation Immediate Release Mucoadhesive Buccal Tablet of Midodrine HCL." Asian Journal of Pharmaceutical Research and Development 12, no. 4 (2024): 28–36. http://dx.doi.org/10.22270/ajprd.v12i4.1437.

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This study aimed to develop and optimize immediate-release mucoadhesive buccal tablets of Midodrine Hydrochloride, intended for rapid onset of action in treating hypotensive states. The tablets were prepared using a direct compression method, with various formulations optimized through a 32 randomized full factorial design, focusing on Crospovidone and Carbopol 934P as independent variables affecting diffusion time and mucoadhesive strength. The optimized batch F3 demonstrated superior performance, with a disintegration time of 20 seconds and an in vitro release of 98.25% within 5 minutes, mee

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Suttee, Ashish, and Pavani S. "Formulation and Evaluation of Buccoadhesive Tablets of Diltiazem Hydrochloride." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 12, no. 03 (2022): 981–84. http://dx.doi.org/10.25258/ijddt.12.3.10.

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Calcium channel blocker diltiazem hydrochloride is used to treat hypertension and angina. The study aimed to develop and evaluate bioadhesive buccal tablets that would bypass hepatic metabolism and boost bioavailability. With the use of bioadhesive polymers like kondagogu gum and guar gum in various concentrations, the direct compression method was used to manufacture buccal tablets. Fourier-transform spectroscopy (FT-IR) spectroscopy analysis of the physicochemical compatibility of the active ingredient and excipients demonstrates that the excipients are compatible with the active component.

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B., Mounika* M. Mahesh M. Preethi P. Sravani S. Sarojini K. Rajeswar Dutt. "FORMULATION DEVELOPMENT AND EVALUATION OF BUCCAL TABLETS OF PANTOPRAZOLE." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 04 (2018): 2238–43. https://doi.org/10.5281/zenodo.1215689.

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The aim of present work is to formulate and evaluate buccal tablets of protonix (pantoprazole sodium) which is subjected to first pass effect and having short half life. To increase the bio availability of a protonix by delivering through the buccal mucosa, as it is a potential site for direct delivery of drugs into systemic circulation. To control the drug release from the tablets by using matrix forming bioadhesive polymers, as the half life of drug is very low. To study the effect of drug : polymer ratio on drug release and other bioadhesive properties. Key words: Buccal, Protonix, Bioadhes

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jin, Hye. "Ondansetron Hydrochloride in Treating Patients with Cancer and Chronic Nausea Vomiting." Cancer Research and Cellular Therapeutics 1, no. 2 (2017): 01–04. http://dx.doi.org/10.31579/2640-1053/012.

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The objective of this study was to develop effective bioadhesive buccal bilayered tablets comprising of drug containing bioadhesive layer and drug free backing layer, expected to release the drug in unidirection for extended period of time. Tablets of ondansetron HCl were prepared by direct compression method using bioadhesive polymers like Carbopol 934P, Methocel K4M, Methocel K15M and Hydroxy propyl cellulose in different combinations and concentrations with backing layer of ethyl cellulose. Buccal tablets were evaluated by different parameters such as thickness, hardness, weight uniformity,

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Raganathan, Venkatalakshmi, Muhammad Zulfahmi Bin Abd Majid, Prasanthi Sri, and Sasikala Chinnappan. "Formulation and evaluation of Diclofenac sodium mucoadhesive buccal tablets by using natural polymers." International Journal of Research in Pharmaceutical Sciences 9, no. 1 (2018): 236. http://dx.doi.org/10.26452/ijrps.v9i1.1253.

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Diclofenac sodium is a common and widely-used drug for the treatment of pain, inflammation and also migraine. Unfortunately, it undergoes extensive first-pass hepatic metabolism when administered through the oral systemic route. Thus, this study will be about the formulation of mucoadhesive buccal tablets of diclofenac sodium that can prevent the extensive metabolism of the drug, which in turn increases its bioavailability inside the systemic circulation. This formulation might also reduce the dosing frequency, which can lead to a better patient compliance to the medication. The formulations w

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Roychowdhury, Santanu, Rajesh Gupta, and Sourav Saha. "A Review on Buccal Mucoadhesive Drug Delivery Systems." Indo Global Journal of Pharmaceutical Sciences 01, no. 03 (2011): 223–33. http://dx.doi.org/10.35652/igjps.2011.22.

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Buccal mucosa is the preferred site for both systemic and local drug action. The mucosa has a rich blood supply and it relatively permeable. In this review article the advantages and limitations related to the buccal drug delivery has also been discussed. In buccal drug delivery systems mucoadhesion is the key element so various mucoadhesive polymers have been utilized in different dosages form. Various bioadhesive dosages form such as Chewing gum, tablets, Patches, Hydrogel, Thiolated tablets are discussed in this review article. Lastly the absorption/permeation study and different dissolutio

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Walse, Prapti V., Sandip T. Thoke, UMESH THAWARA JADHAO, et al. "Formulation and Evaluation of Mucoadhesive Buccal Tablets of Carvedilol." Journal of Drug Delivery and Therapeutics 14, no. 11 (2024): 24–30. http://dx.doi.org/10.22270/jddt.v14i11.6876.

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The aim of the study was to formulate and evaluate the carvedilol buccal tablets using HPMC K4M and xanthan gum as polymer. Buccal tablets of carvedilol were prepared by direct compression technique by using polymer in combination at different concentration. Drug excipient compatibility study indicates that there is no interaction between the excipient and the drug. Total seven batches were prepared and subjected to evaluation parameters. Pre-compression parameters for all batches showed excellent flow propertied of powder bled. Prepared buccal tablets were evaluated for various post compressi

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Harish, Kokate* Dnyaneshwar Khade Vrushali Nikhade. "Fast Disintegrating Tablets: A Review on Novel Drug Delivery System." International Journal of Pharmaceutical Sciences 3, no. 6 (2025): 56–70. https://doi.org/10.5281/zenodo.15569265.

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Fast Disintegrating Tablets (FDTs) are a promising class of oral drug delivery  tablets that dissolve or disintegrate quickly in saliva, offering a practical and patient-friendly alternative for various populations. These tablets dissolve quickly in the buccal cavity, allowing direct absorption through the mucosa, ensuring prompt therapeutic effects. They have advantages such as improved tongue feel, ease of administration, accurate dose, and comfort for bedridden or mobile patients. However, they also have drawbacks like brittleness, hygroscopicity, mechanical strength, and unpleasant sc

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De Jesús Valle, María José, Aranzazu Zarzuelo Castañeda, Cristina Maderuelo, et al. "Development of a Mucoadhesive Vehicle Based on Lyophilized Liposomes for Drug Delivery through the Sublingual Mucosa." Pharmaceutics 14, no. 7 (2022): 1497. http://dx.doi.org/10.3390/pharmaceutics14071497.

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A pharmaceutical vehicle based on lyophilized liposomes is proposed for the buccal administration of drugs aimed at systemic delivery through the sublingual mucosa. Liposomes made of egg phosphatidylcholine and cholesterol (7/3 molar ratio) were prepared and lyophilized in the presence of different additive mixtures with mucoadhesive and taste-masking properties. Palatability was assayed on healthy volunteers. The lyophilization cycle was optimized, and the lyophilized product was compressed to obtain round and capsule-shaped tables that were evaluated in healthy volunteers. Tablets were also

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Singh, Sudarshan, Sandip G. Maru, and Sunil Bothara B. "Formulation and Ex-vivo Evaluation of Glipizide Buccal Tablets." International Journal of Pharmaceutical Sciences and Nanotechnology 7, no. 2 (2014): 2487–93. http://dx.doi.org/10.37285/ijpsn.2014.7.2.10.

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Bioadhesive materials are agents which adhere to the mucous membrane due to specific properties and release the drug at the site of action in controlled manner. Since the biodegradability of the synthetic polymer is at some instance hesitant. In this exploration, a bioadhesive polymer has been developed which was isolated from leaves of Aloe vera (L.) Burm. f. The mucilage isolated from A. vera were used as a bioadhesive polymer in tablet formulation and evaluated for the parameters such as swelling, pH, and bioadhesive property like bioadhesive strength, record of adherence and ex-vivo reside

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Manogna, Katta, P. Nagaveni, and K. Thyagaraju. "A Review On Mucoadhesive Bilayer Buccal Tablets." American Journal of PharmTech Research 8, no. 1 (2018): 101–15. http://dx.doi.org/10.46624/ajptr.2018.v8.i1.007.

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Gajdziok, Jan, Martina Bajerová, Zuzana Chalupová, and Miloslava Rabišková. "Oxycellulose as mucoadhesive polymer in buccal tablets." Drug Development and Industrial Pharmacy 36, no. 9 (2010): 1115–30. http://dx.doi.org/10.3109/03639041003690031.

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LOWRY, FRAN. "Fentanyl Buccal Tablets Effective for Breakthrough Pain." Internal Medicine News 41, no. 11 (2008): 32. http://dx.doi.org/10.1016/s1097-8690(08)70636-x.

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Knapczyk, Jan. "Antimycotic buccal and vaginal tablets with chitosan." International Journal of Pharmaceutics 88, no. 1-3 (1992): 9–14. http://dx.doi.org/10.1016/0378-5173(92)90298-g.

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Chaudhari, Priyanka Dilip, Amol Bhalchandra Deore, Manoj Jagannath Jagtap, and Devanshi Sunil Gupta. "Formulation Development and Evaluation of Mucoadhesive Buccal Tablets of Acebutolol Hydrochloride." Asian Journal of Pharmaceutical Research and Development 10, no. 4 (2022): 34–46. http://dx.doi.org/10.22270/ajprd.v10i4.1156.

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A mucoadhesive drug delivery system is an oral dosage form, where the tablet, gel, or patch is attached to the buccal region for direct absorption of the drug into blood circulation. This dosage form has been employed to improve the bioavailability of drugs that undergoes significant hepatic first-pass metabolism. Acebutolol is a beta sympatholytic agent used to treat high blood pressure and irregular heartbeat (arrhythmia). Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. In present investigation, mucoadhesive buccal tablets of acebutolol HCl were prepar

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Targhotra, Monika, and Meenakshi K. Chauhan. "An Overview on Various Approaches and Recent Patents on Buccal Drug Delivery Systems." Current Pharmaceutical Design 26, no. 39 (2020): 5030–39. http://dx.doi.org/10.2174/1381612826666200614182013.

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Background: Buccal delivery is an alluring course of organization for fundamental medication conveyance and it leads direct access to the systemic flow through the interior jugular vein sidesteps drugs from the hepatic first-pass digestion gives high bioavailability. Objective: This article aims at buccal medication conveyance by discussing the structure and condition of the oral mucosa and the novel strategies utilized in evaluating buccal medication ingestion. Methods: This review highlights the various pharmaceutical approaches for buccal delivery such as buccal tablets, buccal lozenges, bu

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Sharmin, Nahid, Md Elias-Al-Mamun, Md Saiful Islam, and Reza-ul Jalil. "Preparation and Characterization of Lidocaine Double Layer Buccal Tablet Using Mucoadhesive Carbopol® Polymers." Dhaka University Journal of Pharmaceutical Sciences 10, no. 1 (2012): 29–34. http://dx.doi.org/10.3329/dujps.v10i1.10012.

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The present study was intended to develop a new oral mucosal dosage form with a view of solving problems of the topical administration of Lidocaine, a local anesthetic drug, in the oral cavity. The drug was formulated as sustained release mucoadhesive bilayered tablets using mucoadhesive polymers. The first layer, consisting of a drug impermeable backing, was prepared by compression of Kollidon SR, Mg-stearate, Aerosil and talc blend in a hydrolic press at 5 ton pressure for 5 seconds. The second layer, responsible for buccal drug delivery and tablet retention on the mucosa was obtained by com

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Waidya, Kuldeep P., S. Ramya Sri, and T. Janaki. "Formulation Development and Characterisation of Repaglinide Buccal Tablets." Asian Journal of Pharmacy and Technology 9, no. 2 (2019): 79. http://dx.doi.org/10.5958/2231-5713.2019.00014.x.

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