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Journal articles on the topic 'Budesonide nasal irrigation'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Periasamy, Nikitha, Kailesh Pujary, Ajay M. Bhandarkar, Naveen D. Bhandarkar, and Balakrishnan Ramaswamy. "Budesonide vs Saline Nasal Irrigation in Allergic Rhinitis: A Randomized Placebo-Controlled Trial." Otolaryngology–Head and Neck Surgery 162, no. 6 (2020): 979–84. http://dx.doi.org/10.1177/0194599820919363.

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Objectives Budesonide nasal irrigation is currently widely used in the treatment of chronic sinusitis typically following endoscopic sinus surgery to improve inflammatory control. Its application in treatment of allergic rhinitis has not been previously studied. This study assesses the subjective and clinical response to budesonide buffered hypertonic saline nasal irrigation and hypertonic saline nasal irrigation in patients with allergic rhinitis. Study Design This is a prospective, single-center, double-blind, randomized placebo-controlled trial. Setting Tertiary care hospital. Subjects and

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Ishak, Muhammad Nu’aim, Norasnieda Md Shukri, and Ramiza Ramza Ramli. "The Effectiveness of Budesonide Nasal Irrigation in Patients with Allergic Rhinitis." Malaysian Journal of Medical Sciences 29, no. 1 (2022): 34–42. http://dx.doi.org/10.21315/mjms2022.29.1.4.

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Background: Allergic rhinitis (AR) is a long-standing disease and has been shown to cause significant impairment in patients’ quality of life. Saline nasal irrigation is a proven adjunct in the treatment of AR. The addition of steroid to the saline solution can provide local steroid effect and increase the effectiveness of this technique. Our study aimed to determine the effectiveness of budesonide nasal irrigation as an adjunct to the treatment of AR, compared with saline nasal irrigation. Methods: This was a randomised controlled study involving 99 patients diagnosed with AR, half of whom we

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Srinivasa Rao, U., S. A. S. Farooq, and J. Ranga Lakshmi. "A comparative study on the effectiveness of budesonide nasal irrigation versus normal saline nasal irrigation in post endoscopic sinus surgery patients." IP Journal of Otorhinolaryngology and Allied Science 4, no. 3 (2021): 98–105. http://dx.doi.org/10.18231/j.ijoas.2021.020.

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: Comparative studies evaluating budesonide and saline nasal irrigations for patients with polyposis/ rhinosinusitis are deficient in the current literature. This study aimed to evaluate the effectiveness of budesonide nasal irrigations compared with saline irrigations during postoperative care of patients with rhinosinusitis.: A total of 100 patients who underwent functional Endoscopic Sinus SurgeryESS) were randomly divided into two groups (A and B) of 50 participants each (normal saline [NS] + budesonide irrigation and NS irrigation alone, respectively). Pre- and post operative evaluation w

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4

Xu, Chenjie, Yi Shi, Weiqi Hu, and Yingchao Zhu. "Effect of nasal irrigation with budesonide and normal saline on patients with chronic rhino-sinusitis surgery." Tropical Journal of Pharmaceutical Research 23, no. 7 (2024): 1149–55. http://dx.doi.org/10.4314/tjpr.v23i7.14.

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Purpose: To investigate the therapeutic effect of budesonide nasal irrigation and saline irrigation in patients undergoing surgery for chronic rhinosinusitis (CRS). Methods: One hundred patients scheduled for functional endoscopic sinus surgery (FESS) in Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, China were enrolled. The patients were divided into study and control groups comprising 50 cases each. The study group received postoperative budesonide irrigation while control group received normal saline irrigation after surgery. Post-operative symptoms, sign

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5

Jiramongkolchai, Pawina, Siddharth Patel, and John S. Schneider. "Use of Off-Label Nasal Steroid Irrigations in Long-Term Management of Chronic Rhinosinusitis." Ear, Nose & Throat Journal 100, no. 5 (2021): 329–34. http://dx.doi.org/10.1177/0145561321998521.

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Objective: Chronic rhinosinusitis (CRS) is an inflammatory disease of the paranasal sinuses and mucosa. Topical nasal corticosteroids are a mainstay treatment for CRS by reducing sinonasal inflammation and improving mucociliary clearance. However, topical corticosteroids have limited paranasal distribution, and patient response to treatment has been variable in randomized controlled trials (RCT). Thus, there is significant interest in evaluating the efficacy of nasal steroids delivered by nasal irrigation in order to improve penetration and absorption of topical steroids into the sinonasal muc

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Anshu, Kumar, Kumar Pramod, and Pratap Thakur Rana. "A Prospective Study to Evaluate the Effectiveness of Budesonide Nasal Irrigations Comparison with Saline Irrigations During Postoperative Care of Patients with Rhinosinusitis." International Journal of Pharmaceutical and Clinical Research 14, no. 1 (2022): 802–9. https://doi.org/10.5281/zenodo.13869232.

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<strong>Aim:</strong> This study aimed to evaluate the effectiveness of budesonide nasal irrigations compared with saline irrigations during postoperative care of patients with rhinosinusitis. <strong>Materials and Methods:</strong> A total of 200 patients who underwent functional Endoscopic Sinus Surgery (ESS) were randomly divided into two groups (A and B) of 100 participants each (normal saline [NS] + budesonide irrigation and NS irrigation alone, respectively). Pre- and post-operative evaluation was done with a 22-item sinonasal outcomes test (SNOT-22), and Lund Kennedy endo

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7

Kapil, Meena, Sharma Surbhi, Tripathi Abhishek, and George Sonith. "Comparison of Intranasal Fluticasone Propionate Spray and Saline Nasal Irrigation with Budesonide Respules in Patients with Chronic Rhinosinusitis with Nasal Polyposis: A Randomized Clinical Trial." International Journal of Pharmaceutical and Clinical Research 16, no. 10 (2024): 567–73. https://doi.org/10.5281/zenodo.14037265.

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<strong>Background: </strong>Chronic rhinosinusitis with nasal polyposis (CRSwNP) is a challenging condition often managed with intranasal corticosteroids and saline irrigations. <strong>Aim and Objective:</strong> To compare the efficacy and safety of intranasal fluticasone propionate spray versus saline nasal irrigation with budesonide respules in treating patients with CRSwNP. <strong>Materials and Methods: </strong>This randomized controlled trial included 120 patients with CRSwNP, who were assigned to either Group A (intranasal fluticasone propionate spray, n=60)

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8

Lekha, K. A., Shanbag Raghunath, and Ramashesh Rashmi. "Comparative Study on the Efficacy of Irrigating the Postoperative Fess Cavities [B/L Nasal Polyps] with Topical Nasal Solutions of Budesonide and Betamethasone." International Journal of Pharmaceutical and Clinical Research 16, no. 2 (2024): 1544–49. https://doi.org/10.5281/zenodo.11083531.

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Nasal polyps are benign lesions arising from the mucosa of nasal sinuses (commonly at the outflow tracts of one or more sinuses) or from the mucosa of nasal cavity. Having an uncertain etiology and a tendency to recur, they form a challenging disease to be treated. The present study compares the efficacy of irrigating the postoperative fess cavities with betamethasone and budesonide nasal douche in symptomatic relief, pain score and condition of sinonasal mucosa. A total of 30 subjects with Chronic Rhinosinusitis with nasal polyps were included in the final analysis with 15 subjects receiving

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9

Anjum, Areena, Farkhanda Majeed, Shahid A. Mir, Parmod Kalsotra, and Zuha Showket. "Efficacy of nasal irrigation of normal saline as compared to budesonide following functional endoscopic sinus surgery." International Journal of Research in Medical Sciences 11, no. 5 (2023): 1693–97. http://dx.doi.org/10.18203/2320-6012.ijrms20231338.

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Background: Nasal irrigation following Functional endoscopic sinus surgery (FESS) appears to be a nearly universal recommendation. FESS significantly improves the symptoms of the CRS (Chronic rhino sinusitis) and the postoperative endoscopy scores. The primarily objective of our study was to study the efficacy of nasal irrigation of normal saline as compared to budesonide following functional endoscopic sinus surgery. Methods: A total of 100 patients who underwent functional endoscopic sinus surgery were randomly divided into two groups on the basis of computerized generated random table with

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Riddhi, Nayak, Das Bidhan, Sukla Biswajit, and Chakraborty Arup. "A Comparative Study on the Effectiveness of Budesonide Nasal Irrigation vs. Saline Nasal irrigation in Post-Operative Patients following Functional Endoscopic Sinus Surgery in Cases of Chronic Rhinosinusitis." International Journal of Pharmaceutical and Clinical Research 15, no. 3 (2023): 1166–74. https://doi.org/10.5281/zenodo.12789018.

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<strong>Aim: </strong>To determine the effectiveness of Budesonide nasal irrigation compared to saline irrigation alone in post-operative patients who underwent Functional Endoscopic Sinus Surgery (FESS) in cases of Chronic Rhinosinusitis. <strong>Materials & Methods: </strong>A total of 50 patients who underwent FESS surgery were randomly allocated into two groups. Group 1 (Budesonide group) comprised of 25 patients who received Normal Saline + Budesonide respule nasal irrigation twice daily continuously starting from 48 hours after surgery. Group 2 (Normal saline group) co

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11

Marwa, Abdelhafeez, and Ali Elkholi Safaa Mostafa. "Efficacy of olfactory training program in conjunction with nasal steroid irrigation in treating persistent smell loss in COVID-19 patients." Archives of Otolaryngology and Rhinology 8, no. 1 (2022): 001–6. http://dx.doi.org/10.17352/2455-1759.000144.

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Background: Smell loss is a challenging clinical problem. There is still no evidence-based medical intervention to treat patients with persistent smell loss as a result of Coronavirus Disease 2019 (COVID-19). The aim is to analyze the efficacy of treating patients with persistent smell loss due to COVID-19 using olfactory training (OT) combined with nasal steroid irrigation. Methods: A cross-sectional study enrolled 196 COVID-19 patients with persistent smell loss were recruited. All patients underwent two testing sessions. At the first session, patients were examined by a history taking follo

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12

Jung, Seon Min, Jin Hye Kwak, Moo Keon Kim, Kyung Tae, Seok Hyun Cho, and Jin Hyeok Jeong. "The Long-Term Effects of Budesonide Nasal Irrigation in Chronic Rhinosinusitis with Asthma." Journal of Clinical Medicine 11, no. 10 (2022): 2690. http://dx.doi.org/10.3390/jcm11102690.

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Chronic rhinosinusitis with nasal polyps (CRSwNP) in asthmatic patients has a high recurrence rate even after surgery. For this reason, oral steroids are frequently used, but their long-term use may cause side effects. The purpose of this study is to investigate the long-term effects of budesonide nasal irrigation (BNI) in CRSwNP and asthma. An analysis of 33 patients with CRSwNP and well-controlled asthma, who performed BNI for more than 12 months, was performed. We compared oral steroid and antibiotic dosages as well as nasal endoscopy scores before, and every six months after, BNI. The six-

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13

Purushothaman, P. K. "A study on efficacy of budesonide nasal irrigation in post-operative fess." MedPulse International Journal of ENT 14, no. 3 (2020): 41–47. http://dx.doi.org/10.26611/10161432.

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14

Kim, Bo Soo, Hyeon Woo Ahn, Tae Lim An, et al. "The Effect of Nasal Budesonide Irrigation or Intranasal Steroid on Olfactory Disorders." Journal of Clinical Otolaryngology Head and Neck Surgery 34, no. 3 (2023): 69–75. http://dx.doi.org/10.35420/jcohns.2023.34.3.69.

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Alrasheedi, A. N. "Characterization, treatment modalities, and self-perceived improvement of post-COVID-19 phantosmia: a case series of eleven patients." Rhinology Online 5, no. 5 (2022): 44–48. http://dx.doi.org/10.4193/rhinol/22.003.

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Background: Loss of smell and taste is one of the early and sensitive symptoms of COVID-19 that usually improves over time. Post-COVID-19 phantosmia, a smell distorted sensation without the presence of odorants, has deleterious and long-lasting effects on the patient's quality of life. We aimed to present our experience with phantosmia. Case presentations: We report a description of a series of eleven cases (age of 29 ± 9 years, and 54.5% females) of post-COVID-19 phantosmia without any other comorbidity, and the effects of combined treatment modalities (olfactory training, nasal irrigation wi

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16

Wang, Zijing, Lin Han, and Lisheng Yu. "Effects of surgery and topical medication on eosinophilic granulomatosis with polyangiitis with otitis media and sinusitis: a case report." Journal of International Medical Research 48, no. 4 (2020): 030006052092004. http://dx.doi.org/10.1177/0300060520920049.

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Eosinophilic granulomatosis with polyangiitis (EGPA), also known as Churg–Strauss syndrome, is eosinophil-rich, necrotizing granulomatous inflammation often involving the respiratory tract. Furthermore, EGPA is necrotizing vasculitis that predominantly affects small to medium vessels and is associated with asthma and eosinophilia. Most patients with EGPA have sinusitis and some complain of hearing loss and refractory otitis media with effusion. Systemic use of immunosuppressants and glucocorticoids is currently recommended, despite the inevitable associated side effects. However, systemic trea

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17

Kang, Tae Wook, Jae Ho Chung, Seok Hyun Cho, Seung Hwan Lee, Kyung Rae Kim, and Jin Hyeok Jeong. "The Effectiveness of Budesonide Nasal Irrigation After Endoscopic Sinus Surgery in Chronic Rhinosinusitis With Asthma." Clinical and Experimental Otorhinolaryngology 10, no. 1 (2017): 91–96. http://dx.doi.org/10.21053/ceo.2016.00220.

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18

Thanneru, Maheshbabu, Sowmya Lanke, and Shanti Kolavali. "The Effectiveness of Budesonide Nasal Irrigation After Endoscopic Sinus Surgery in Chronic Allergic Rhinosinusitis with Polyps." Indian Journal of Otolaryngology and Head & Neck Surgery 72, no. 3 (2020): 350–54. http://dx.doi.org/10.1007/s12070-020-01878-x.

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19

Huang, Zi-zhen, Xian-zhen Chen, Jian-cong Huang, et al. "Budesonide nasal irrigation improved Lund–Kennedy endoscopic score of chronic rhinosinusitis patients after endoscopic sinus surgery." European Archives of Oto-Rhino-Laryngology 276, no. 5 (2019): 1397–403. http://dx.doi.org/10.1007/s00405-019-05327-6.

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20

Jang, David W., Vasileios A. Lachanas, Jamie Segel, and Stilianos E. Kountakis. "Budesonide nasal irrigations in the postoperative management of chronic rhinosinusitis." International Forum of Allergy & Rhinology 3, no. 9 (2013): 708–11. http://dx.doi.org/10.1002/alr.21189.

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21

Kosugi, Eduardo Macoto, Guilherme Figner Moussalem, Juliana Caminha Simões, et al. "Topical therapy with high-volume budesonide nasal irrigations in difficult-to-treat chronic rhinosinusitis." Brazilian Journal of Otorhinolaryngology 82, no. 2 (2016): 191–97. http://dx.doi.org/10.1016/j.bjorl.2015.03.014.

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22

Kaur, Gurkiran, Sanjeev Bhagat, Dimple Sahni, Vishal Sharma, and Ankur Mohan. "A comparative study of budesonide versus saline irrigations in postoperative care of patients with nasal polyposis." B-ENT 16, no. 2 (2020): 91–96. http://dx.doi.org/10.5152/b-ent.2020.20004.

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23

Soudry, Ethan, Jane Wang, Reza Vaezeafshar, Laurence Katznelson, and Peter H. Hwang. "Safety analysis of long-term budesonide nasal irrigations in patients with chronic rhinosinusitis post endoscopic sinus surgery." International Forum of Allergy & Rhinology 6, no. 6 (2016): 568–72. http://dx.doi.org/10.1002/alr.21724.

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Megow, Anna, George Bouras, Eng H. Ooi, Sarah Vreugde, Alkis Psaltis, and Peter‐John Wormald. "Double blind randomized controlled trial measuring the efficacy of nebulized steroid at half dose in comparison to high volume squeeze bottle steroid irrigation in management of patients with chronic rhinosinusitis." International Forum of Allergy & Rhinology, March 13, 2024. http://dx.doi.org/10.1002/alr.23336.

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Promsopa, Chakapan, Thanapa Quannuy, Suchet Chinpairoj, Virat Kirtsreesakul, Usaporn Prapaisit, and Nichana Suwanparin. "A Randomized, Double‐Blind Study Comparing Corticosteroid Irrigations and Nasal Sprays for Polyp Size Reduction in CRSwNP." Laryngoscope, May 7, 2025. https://doi.org/10.1002/lary.32250.

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ABSTRACTObjectiveTo compare the efficacy of corticosteroid irrigation (CSI) and intranasal corticosteroid spray (INCS) in reducing polyp size, improving nasal symptoms, and assessing HPA‐axis suppression in non‐surgical patients with chronic rhinosinusitis with nasal polyps (CRSwNP).MethodsTwenty‐four patients from the Allergy and Rhinology Clinic, Songklanagarind Hospital, were randomized into: CSI + placebo spray (n = 13): Budesonide irrigation (0.5 mg/day) + saline spray. Placebo irrigation + INCS (n = 11): Saline irrigation + budesonide spray (512 mcg/day). Nasal symptoms were assessed usi

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Magboul, N., A. F. Alharbi, A. T. Alqutub, et al. "Budesonide nasal irrigation for chronic rhinosinusitis: a meta-analysis of therapeutic outcomes and safety profile." Rhinology Journal, December 1, 2024, 0. https://doi.org/10.4193/rhin24.349.

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Background: Corticosteroids are used in managing Chronic Rhinosinusitis (CRS) through several formulations, including oral steroids and nasal sprays. More recently, incorporating concentrated budesonide respules into high-volume saline irrigations has been proposed to enhance the penetration of topical steroids into the paranasal sinuses. We aim to evaluate the safety and efficacy of budesonide nasal irrigation (BNI) in managing CRS. Methodology: A systematic review with meta-analysis was performed following PRISMA guidelines. Data were extracted independently from the eligible studies. In dou

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Bertazzoni, Giacomo, Carlo Conti, Gabriele Testa, et al. "High volume nasal irrigations with steroids for chronic rhinosinusitis and allergic rhinitis." European Archives of Oto-Rhino-Laryngology, September 26, 2024. http://dx.doi.org/10.1007/s00405-024-08901-9.

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Abstract Purpose The primary aim of this systematic review is to assess the efficacy, safety, and cost-effectiveness of high-volume steroid nasal irrigation (SNI) for treating chronic rhinosinusitis (CRS) and allergic rhinitis (AR). Methods A systematic review of literature from 2012 to 2024 was conducted using PubMed to identify relevant studies. The search focused on terms related to AR, CRS, and steroid nasal irrigation. Studies were screened for relevance and duplicates removed, resulting in 20 studies being included in the final analysis. These studies were categorized based on their focu

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Kang, Tae Wook, Jae Ho Chung, Seok Hyun Cho, Seung Hwan Lee, Kyung Rae Kim, and Jin Hyeok Jeong. "The Effectiveness of Budesonide Nasal Irrigation After Endoscopic Sinus Surgery in Chronic Rhinosinusitis With Asthma." Clinical and Experimental Otorhinolaryngology, July 21, 2016. http://dx.doi.org/10.21053/ceo.2016.00020.

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29

Kothiwala, Mamta, Sunil Samdani, Mohnish Grover, and Vishram Gurjar. "Efficacy of Topical High Volume Budesonide Nasal Irrigation in Post FESS Patients of Chronic Rhinosinusitis With or Without Nasal Polyposis." Indian Journal of Otolaryngology and Head & Neck Surgery, April 15, 2021. http://dx.doi.org/10.1007/s12070-021-02509-9.

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Rathi, Vinay K., Nicholas W. Sawicki, Rodney J. Schlosser, et al. "Adverse events associated with budesonide nasal irrigation reported to US food and drug administration, 2007‐2022." International Forum of Allergy & Rhinology, July 2, 2023. http://dx.doi.org/10.1002/alr.23232.

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31

Luz-Matsumoto, Gabriela Ricci, Erika Cabernite Marchetti, Layla Sayuri Kaczorowski Sasaki, et al. "Nasal irrigation with corticosteroids in Brazil: the clinical response of 1% compounded budesonide drops and betamethasone cream." Brazilian Journal of Otorhinolaryngology, August 2021. http://dx.doi.org/10.1016/j.bjorl.2021.06.008.

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Armstrong, Michael F., Thomas J. O’Byrne, Jason J. Calva, et al. "The Feasibility of Investigating Acupuncture in Patients With COVID-19 Related Olfactory Dysfunction." Global Advances in Integrative Medicine and Health 14 (May 2025). https://doi.org/10.1177/27536130251343834.

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Background Olfactory dysfunction (OD) is a common symptom in patients with coronavirus disease 2019 (COVID-19) with limited treatment options. Objective This pilot study aimed to investigate an acupuncture protocol in patients with COVID-19 related OD. Methods Thirty patients were randomized into 2 groups. The standard group was treated with budesonide nasal irrigation and olfactory training. The acupuncture group received ten sessions of acupuncture therapy in addition to the standard group treatment. Olfaction was assessed using the University of Pennsylvania Smell Identification Test, 10-po

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Jia, Yizhen, Junhao Tu, Binxiang Tang, Fan Jiang, Qing Luo, and Jing Ye. "Impact of Nasal Glucocorticoid Therapy on Exhaled Nitric Oxide and Symptom Relief in Chronic Rhinosinusitis with Nasal Polyps: A Randomized Prospective Study." International Archives of Allergy and Immunology, February 26, 2025, 1–24. https://doi.org/10.1159/000544872.

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Introduction Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) is a widespread inflammatory disease, classified into Eosinophilic (EosCRSwNP) and non-Eosinophilic (non-EosCRSwNP) types. Nitric oxide (NO) plays a role in pathophysiological processes, with changing levels in airway diseases like asthma and CRS. Intranasal corticosteroids (INCS) are first-line treatments for CRSwNP, providing anti-inflammatory and immunomodulatory effects pre- and post-endoscopic sinus surgery (ESS). This study examines the influence of nasal steroids on nasal exhaled nitric oxide (FnNO) post-ESS in EosCRSwNP and

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Jing, Qi, Jian Song, Guanghui An, et al. "Effective early strategy to prevent olfactory and gustatory dysfunction in COVID-19: A randomized controlled trial." QJM: An International Journal of Medicine, November 21, 2023. http://dx.doi.org/10.1093/qjmed/hcad262.

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Abstract Background Olfactory and gustatory dysfunctions (OGDs) are key symptoms of COVID-19, which may lead to neurological complications, and lack of effective treatment. This may be because post-disease treatments may be too late to protect the olfactory and gustatory functions. Aim To evaluate the effectiveness of early use of saline nasal irrigation (SNI), corticosteroid nasal spray, and saline or chlorhexidine gluconate mouthwash for preventing OGDs in COVID-19. Design This study was a double-blind randomized controlled trial. Methods The study was conducted from May 5 to June 16, 2022.

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"Effect of budesonide nasal irrigation on Hypothalamic-Pituitary-Adrenal Axis in patients with chronic rhinosinusitis post endoscopic sinus surgery: A prospective study." Asian Pacific Journal of Allergy and Immunology, 2025. https://doi.org/10.12932/ap-121124-1968.

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Suligavi, Shashidhar S., Varsha Sridhar, and Sangappa S. Doddamani. "Outcome of Post Functional Endoscopic Sinus Surgery Nasal Irrigation with Normal Saline Versus Normal Saline with Budesonide in Patients with Sinonasal Polyposis: A Randomized Control Trial." Indian Journal of Otolaryngology and Head & Neck Surgery, April 17, 2024. http://dx.doi.org/10.1007/s12070-024-04666-z.

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"Is Add-on Budesonide-Impregnated Nasal Dressing Useful Following Endoscopic Sinus Surgery with Perioperative Oral Steroid?" Journal of the Medical Association of Thailand 104, no. 2 (2021): 293–99. http://dx.doi.org/10.35755/jmedassocthai.2021.02.11902.

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Background: Some chronic rhinosinusitis with nasal polyps patients undergoing endoscopic sinus surgery (ESS) have unfavorable results despite proper postoperative treatments including oral and topical steroids. Steroid-impregnated absorbable nasal dressing has been shown to improve outcomes of the surgery. In some clinical practices, budesonide-impregnated nasal dressing is used together with perioperative oral steroid but the additional benefits of it are still unknown. Objective: To determine whether budesonide-impregnated nasal dressing had any benefits following ESS when a short course of

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Vuncannon, Jackson R., Khaled A. Altartoor, Anastasia Kolousek, et al. "Impact of Topical Corticosteroid Irrigations on Sinonasal Wound Healing." American Journal of Rhinology & Allergy, April 21, 2025. https://doi.org/10.1177/19458924251334854.

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Background Chronic rhinosinusitis with nasal polyps (CRSwNP) is a chronic inflammatory disease frequently requiring surgical intervention and the long-term use of topical corticosteroids to control patient symptoms. However, corticosteroids may delay postoperative recovery following sinus surgery by disrupting tissue inflammation, a key mediator of early wound healing. This study therefore seeks to assess the impact of topical corticosteroids on sinonasal epithelial healing following local injury. Methods Primary human nasal epithelial cells (HNECs) were collected from two patients with CRSwNP

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Talat, Rehab, Isabelle Gengler, Katie M. Phillips, David S. Caradonna, Stacey T. Gray, and Ahmad R. Sedaghat. "Chronic Rhinosinusitis Outcomes of Patients With Aspirin-Exacerbated Respiratory Disease Treated With Budesonide Irrigations: A Case Series." Annals of Otology, Rhinology & Laryngology, November 14, 2021, 000348942110549. http://dx.doi.org/10.1177/00034894211054948.

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Background: Pathophysiology-targeting treatments exist for aspirin-exacerbated respiratory disease (AERD) through aspirin desensitization and biologics, such as dupilumab. With increasing attention paid to these treatments, which may be associated with significant side effects and/or cost, there is little description of chronic rhinosinusitis with nasal polyps (CRSwNP) response to treatment with intranasal corticosteroids and saline irrigations in AERD. Objective: To determine the effect of intranasal budesonide irrigations for the treatment of CRSwNP in AERD. Methods: This is an observational

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Fowler, James, Brian W. Rotenberg, and Leigh J. Sowerby. "The subtle nuances of intranasal corticosteroids." Journal of Otolaryngology - Head & Neck Surgery 50, no. 1 (2021). http://dx.doi.org/10.1186/s40463-020-00480-z.

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Abstract Background In the specialty of Otolaryngology – Head and Neck Surgery, intranasal corticosteroids are the mainstay treatment for inflammatory processes within the nasal cavity. All too often, physician prescribing patterns are based on previous training, personal experience, and interactions with industry. The purpose of this commentary is to review the nuances of each intranasal corticosteroid. Commentary There are nine intranasal corticosteroids approved for use in Canada. Each are discussed in detail, including their indication, bioavailability, effects on intranasal environment, a

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