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1
Shelton, Janie, Peter Wallner, Georg Pommer, Dagmar Seidl, Dieter Werner, and Hans-Peter Hutter. "Predictors of residential mold growth in Vienna, Austria." ISEE Conference Abstracts 2013, no. 1 (September 19, 2013): 4464. http://dx.doi.org/10.1289/isee.2013.p-1-19-17.
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Kirchengast, Sylvia, and Beda Hartmann. "Pregnancy Outcome during the First COVID 19 Lockdown in Vienna, Austria." International Journal of Environmental Research and Public Health 18, no. 7 (April 5, 2021): 3782. http://dx.doi.org/10.3390/ijerph18073782.
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The COVID 19 pandemic represents a major stress factor for non-infected pregnant women. Although maternal stress during pregnancy increases the risk of preterm birth and intrauterine growth restriction, an increasing number of studies yielded no negative effects of COVID 19 lockdowns on pregnancy outcome. The present study focused on pregnancy outcome during the first COVID 19 lockdown phase in Austria. In particular, it was hypothesized that the national lockdown had no negative effects on birth weight, low birth weight rate and preterm birth rate. In a retrospective medical record-based single center study, the outcome of 669 singleton live births in Vienna Austria during the lockdown phase between March and July 2020 was compared with the pregnancy outcome of 277 live births at the same hospital during the pre-lockdown months of January and February 2020 and, in addition, with the outcome of 28,807 live births between 2005 and 2019. The rate of very low gestational age was significantly lower during the lockdown phase than during the pre-lockdown phase. The rate of low gestational age, however, was slightly higher during the lockdown phase. Mean birth weight was significantly higher during the lockdown phase; the rates of low birth weight, very low birth weight and extremely low birth weight were significantly lower during the lockdown phase. In contrast, maternal gestational weight gain was significantly higher during the lockdown phase. The stressful lockdown phase in Austria seems to have no negative affect on gestational length and newborn weight among non-infected mothers.
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Kreidl, Peter, Daniela Schmid, Sabine Maritschnik, Lukas Richter, Wegene Borena, Jakob-Wendelin Genger, Alexandra Popa, et al. "Emergence of coronavirus disease 2019 (COVID-19) in Austria." Wiener klinische Wochenschrift 132, no. 21-22 (August 20, 2020): 645–52. http://dx.doi.org/10.1007/s00508-020-01723-9.
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SummaryThis is a report on the first identified cases of coronavirus disease 2019 (COVID-19) in Austria. The first documented case was a person who stayed in Kühtai, Tyrol, from 24 to 26 January 2020, and had been infected by a Chinese instructor in Starnberg (Germany) between 20 and 22 January. This counts as a German case since her diagnosis was eventually made in Munich (Germany) on 28 January. On 25 February, two cases imported from Italy were diagnosed in Innsbruck but again no secondary cases were identified in Austria. The first three infections of Austrian inhabitants were detected on 27 February in Vienna. The two resulting clusters finally included 6 (source of initial infection unknown) and 61 cases. Most likely, Italy was the source of the latter cluster. On 12 March the first fatal case of COVID-19 in Austria was reported, a 69-year-old Viennese who died in a Vienna hospital after returning from a cruise ship tour in Italy. On 6 March three autochthonously acquired cases were reported in the Tyrol, all related to the ski resort Ischgl. Of the first 14 Islandic COVID-19 cases infected in Ischgl, 11 had already returned to Iceland on 29 February. We consider that the incriminated barkeeper, who tested PCR positive on 7 March, was neither the primary case nor a superspreader. In our opinion, undetected transmission of SARS-CoV‑2 had been ongoing in Ischgl prior to the first laboratory confirmed cases. Our data also underline that the introduction of SARS-CoV‑2 into Austria was not one single event.
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Hutter, Hans-Peter, Michael Poteser, Hanns Moshammer, Kathrin Lemmerer, Monika Mayer, Lisbeth Weitensfelder, Peter Wallner, and Michael Kundi. "Air Pollution Is Associated with COVID-19 Incidence and Mortality in Vienna, Austria." International Journal of Environmental Research and Public Health 17, no. 24 (December 11, 2020): 9275. http://dx.doi.org/10.3390/ijerph17249275.
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We determined the impact of air pollution on COVID-19-related mortality and reported-case incidence, analyzing the correlation of infection case numbers and outcomes with previous-year air pollution data from the populations of 23 Viennese districts. Time at risk started in a district when the first COVID-19 case was diagnosed. High exposure levels were defined as living in a district with an average (year 2019) concentration of nitrogen dioxide (NO2) and/or particulate matter (PM10) higher than the upper quartile (30 and 20 µg/m3, respectively) of all districts. The total population of the individual districts was followed until diagnosis of or death from COVID-19, or until 21 April 2020, whichever came first. Cox proportional hazard regression was performed after controlling for percentage of population aged 65 and more, percentage of foreigners and of persons with a university degree, unemployment rate, and population density. PM10 and NO2 were significantly and positively associated with the risk of a COVID-19 diagnosis (hazard ratio (HR) = 1.44 and 1.16, respectively). NO2 was also significantly associated with death from COVID-19 (HR = 1.72). Even within a single city, higher levels of air pollution are associated with an adverse impact on COVID-19 risk.
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Ataniyazova, Oral A., Hanns Moshammer, Saeed Yari, Dmitry Ivanov, and Alireza Mosavi Jarrahi. "COVID-19 – sharing experiences of Medical Universities." Asian Pacific Journal of Environment and Cancer 3, S1 (July 17, 2020): 1–2. http://dx.doi.org/10.31557/apjec.2020.3.s1.1-2.
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The Medical University of Karakalpakstan in Nukus, Uzbekistan, as host, in collaboration with the Medical University of Vienna, Austria, and the Saint-Petersburg State Pediatric Medical University from Russia, in May 2020 organized an online seminar with the title “COVID-19 – sharing experiences of Medical Universities”. Indeed the pandemic has hit many countries throughout the world with unexpected force and healthcare systems often were not prepared. That experience clearly showed the need for international cooperation and coordination. It was a sad observation that instead often mistrust and national egoism prevailed.
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Strauss, R., G. Fülöp, and C. Pfeifer. "Tuberculosis in Austria 1995–99: geographical distribution and trends." Eurosurveillance 8, no. 1 (January 1, 2003): 19–26. http://dx.doi.org/10.2807/esm.08.01.00396-en.
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A descriptive analysis of routine surveillance data on tuberculosis (TB) from 1995 to 1999 was performed in Austria. The federal states of Vienna and Upper Austria showed the highest yearly incidences for all five years. In general, however, a decrease of the yearly incidence was observed for all federal states except for Carinthia (where there was a small increase of 3.2 %). In the cities of Vienna, Linz, Wels, Salzburg, Klagenfurt and St-Pölten, as well as in the regions of Eastern Tyrol, Southern Carinthia, and Southern Burgenland, the incidence was above average (>19 cases/100 000 for each). The number of cases per year and per district reported by the statutory reporting system were clearly in excess of those reported by hospitals. The comparison of the two datasets, however, showed a highly significant regional correlation of age standardised morbidity rates at district level. The findings are prone to reporting bias and might not reflect the real TB situation. The responsible health authorities should therefore consider the results as a 'working hypothesis’ in order to review the reporting behaviour at district level.
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Moshammer, Hanns, Michael Poteser, and Hans-Peter Hutter. "COVID-19 and air pollution in Vienna—a time series approach." Wiener klinische Wochenschrift 133, no. 17-18 (May 6, 2021): 951–57. http://dx.doi.org/10.1007/s00508-021-01881-4.
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SummaryWe performed a time series analysis in Vienna, Austria, investigating the temporal association between daily air pollution (nitrogen dioxide, NO2 and particulate matter smaller than 10 µm, PM10) concentration and risk of coronavirus disease 2019 (COVID-19) infection and death. Data covering about 2 months (March–April 2020) were retrieved from public databases. Infection risk was defined as the ratio between infected and infectious. In a separate sensitivity analysis different models were applied to estimate the number of infectious people per day. The impact of air pollution was assessed through a linear regression on the natural logarithm of infection risk. Risk of COVID-19 mortality was estimated by Poisson regression. Both pollutants were positively correlated with the risk of infection with the coefficient for NO2 being 0.032 and for PM10 0.014. That association was significant for the irritant gas (p = 0.012) but not for particles (p = 0.22). Pollutants did not affect COVID-19-related mortality. The study findings might have wider implications on an interaction between air pollution and infectious agents.
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Haselsberger, Beatrix. "The Evolution of Planning Thought Symposium, 19–23 May 2014, Vienna University of Technology, Austria." Planning Perspectives 30, no. 2 (October 16, 2014): 285–90. http://dx.doi.org/10.1080/02665433.2014.963139.
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Van de Werf, F., and G. Breithardt. "Abstracts selected for presentation at the XXth Congress of the European Society of Cardiology, August 22-26,1998, Vienna, Austria." European Heart Journal 19, Abstract Supplement (August 2, 1998): v—viii. http://dx.doi.org/10.1093/eurheartj/19.abstract_supplement.v.
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Alsaffar, Hussain, Senthil Senniappan, and Agnès Linglart. "On X-linked hypophosphatemia at the European society of pediatric endocrinology meeting, Vienna, Austria; september 19–21, 2019." Ibnosina Journal of Medicine and Biomedical Sciences 12, no. 1 (2020): 68. http://dx.doi.org/10.4103/ijmbs.ijmbs_3_20.
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Schreier, Stefan F., Andreas Richter, and John P. Burrows. "Near-surface and path-averaged mixing ratios of NO<sub>2</sub> derived from car DOAS zenith-sky and tower DOAS off-axis measurements in Vienna: a case study." Atmospheric Chemistry and Physics 19, no. 9 (May 3, 2019): 5853–79. http://dx.doi.org/10.5194/acp-19-5853-2019.
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Abstract. Nitrogen dioxide (NO2), produced as a result of fossil fuel combustion, biomass burning, lightning, and soil emissions, is a key urban and rural tropospheric pollutant. In this case study, ground-based remote sensing has been coupled with the in situ network in Vienna, Austria, to investigate NO2 distributions in the planetary boundary layer. Near-surface and path-averaged NO2 mixing ratios within the metropolitan area of Vienna are estimated from car DOAS (differential optical absorption spectroscopy) zenith-sky and tower DOAS horizon observations. The latter configuration is innovative in the sense that it obtains horizontal measurements at more than a hundred different azimuthal angles – within a 360∘ rotation taking less than half an hour. Spectral measurements were made with a DOAS instrument on nine days in April, September, October, and November 2015 in the zenith-sky mode and on five days in April and May 2016 in the off-axis mode. The analysis of tropospheric NO2 columns from the car measurements and O4 normalized NO2 path averages from the tower observations provide interesting insights into the spatial and temporal NO2 distribution over Vienna. Integrated column amounts of NO2 from both DOAS-type measurements are converted into mixing ratios by different methods. The estimation of near-surface NO2 mixing ratios from car DOAS tropospheric NO2 vertical columns is based on a linear regression analysis including mixing height and other meteorological parameters that affect the dilution and reactivity in the planetary boundary layer – a new approach for such conversion. Path-averaged NO2 mixing ratios are calculated from tower DOAS NO2 slant column densities by taking into account topography and geometry. Overall, lap averages of near-surface NO2 mixing ratios obtained from car DOAS zenith-sky measurements, around a circuit in Vienna, are in the range of 3.8 to 26.1 ppb and in good agreement with values obtained from in situ NO2 measurements for days with wind from the southeast. Path-averaged NO2 mixing ratios at 160 m above the ground as derived from the tower DOAS measurements are between 2.5 and 9 ppb on two selected days with different wind conditions and pollution levels and show similar spatial distribution as seen in the car DOAS zenith-sky observations. We conclude that the application of the two methods to obtain near-surface and path-averaged NO2 mixing ratios is promising for this case study.
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Morishita-Steffen, Naomi, Rémi Alberola, Baptiste Mougeot, Étienne Vignali, Camilla Wikström, Uwe Montag, Emmanuel Gastaud, et al. "Smarter Together: Progressing Smart Data Platforms in Lyon, Munich, and Vienna." Energies 14, no. 4 (February 18, 2021): 1075. http://dx.doi.org/10.3390/en14041075.
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In a context where digital giants are increasingly influencing the actions decided by public policies, smart data platforms are a tool for collecting a great deal of information on the territory and a means of producing effective public policies to meet contemporary challenges, improve the quality of the city, and create new services. Within the framework of the Smarter Together project, the cities of Lyon (France), Munich (Germany), and Vienna (Austria) have integrated this tool into their city’s metabolism and use it at different scales. Nevertheless, the principle remains the same: the collection (or even dissemination) of internal and external data to the administration will enable the communities, companies, not-for-profit organizations, and civic administrations to “measure” the city and identify areas for improvement in the territory. Furthermore, through open data logics, public authorities can encourage external partners to become actors in territorial action by using findings from the data to produce services that will contribute to the development of the territory and increase the quality of the city and its infrastructure. Nevertheless, based on data that is relatively complex to extract and process, public data platforms raise many legal, technical, economic, and social issues. The cities either avoided collecting personal data or when dealing with sensitive data, use anonymized aggregated data. Cocreation activities with municipal, commercial, civil society stakeholders, and citizens adopted the strategies and tools of the intelligent data platforms to develop new urban mobility and government informational services for both citizens and public authorities. The data platforms are evolving for transparent alignment with 2030 climate-neutrality objectives while municipalities strive for greater agility to respond to disruptive events like the COVID-19 pandemic.
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Navarro, D. "A report from the 50th Annual Meeting of the European Association for the Study of Diabetes (EASD) (September 15-19, 2014 - Vienna, Austria)." Drugs of Today 50, no. 10 (2014): 703. http://dx.doi.org/10.1358/dot.2014.50.10.2235858.
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Genner, Andreas, Pedro Martín-Mateos, Harald Moser, and Bernhard Lendl. "A Quantum Cascade Laser-Based Multi-Gas Sensor for Ambient Air Monitoring." Sensors 20, no. 7 (March 26, 2020): 1850. http://dx.doi.org/10.3390/s20071850.
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A quantum cascade laser-based sensor for ambient air monitoring is presented and five gases, affecting the air quality, can be quantified. The light sources are selected to measure CO, NO, NO2, N2O and SO2. The footprint of the measurement setup is designed to fit in two standard 19” rack (48 cm × 65 cm) with 4 height units (18 cm) whereas one is holding the optical components and the other one contains the electronics and data processing unit. The concentrations of the individual analytes are measured using 2f-Wavelength Modulation Spectroscopy (2f-WMS) and a commercially available multipass gas cell defines the optical path. In addition, CO can also be measured with a dispersion-based technique, which allows one to cover a wider concentration range than 2f-WMS. The performance of this prototype has been evaluated in the lab and detection limits in the range of 1ppbv have been achieved. Finally, the applicability of this prototype for ambient air monitoring is shown in a five-week measurement campaign in cooperation with the Municipal Department for Environmental Protection (MA 22) of Vienna, Austria.
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Poley, Jared. "Ulrich E. Bach Tropics of Vienna: Colonial Utopias of the Habsburg Empire. Austria and Habsburg Studies Series Volume 19. New York: Berghahn Books, 2016. Pp. 152." Austrian History Yearbook 49 (April 2018): 310–11. http://dx.doi.org/10.1017/s0067237818000395.
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Carlin, Greta Lisa, Oliver Kimberger, Raffaela Morgenbesser, Wolfgang Umek, Heinz Kölbl, Klaus Bodner, and Barbara Bodner-Adler. "Female Pelvic Floor Dysfunction Continues to Negatively Impact Quality-of-Life during the COVID-19 Lockdown." Journal of Clinical Medicine 10, no. 5 (March 5, 2021): 1075. http://dx.doi.org/10.3390/jcm10051075.
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The COVID-19 pandemic led to dramatical changes in elective medical care. We analysed its impact on patients with female pelvic floor dysfunction during the 6 weeks of lockdown in Austria. A cross-sectional study was conducted: All 99 women who presented at the urogynaecologic outpatient clinic of the Medical University of Vienna with pelvic organ prolapse (POP) or urinary incontinence (UI) from December 2019 up to the lockdown in March 2020 were included and contacted. 97% of these women (96 participants) agreed to participate in the survey conducted to asses pelvic floor related quality of life (QoL) through telephone- interrogation. The mean age was 59 ± 14.8 years, the POP group consisted of 42 women while the UI group included 54 women. Most participants (83% of POP and 81% of UI cases) stated that their female pelvic floor dysfunction had remained equally relevant or had become even more significant during the lockdown. Associated symptoms and psychological strain also maintained their relevance during the lockdown (UI: p = 0.229; POP: p = 0.234). Furthermore, 97% of all interviewed women indicated to be strongly willing to continue their treatment. A generalised linear model regression revealed no clinical or demographic risk factors for psychological strain during the lockdown (p > 0.05). Our results demonstrate that women’s QoL remains significantly impaired by their pelvic-floor disorders even during a worldwide crisis such as COVID-19. Therefore, elective disciplines such as urogynaecology urgently require novel and innovative strategies for continued patient care even in times of a lockdown.
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Schubert, Lorenz, Robert Strassl, Heinz Burgmann, Gabriella Dvorak, Matthias Karer, Michael Kundi, Manuel Kussmann, et al. "A Longitudinal Seroprevalence Study Evaluating Infection Control and Prevention Strategies at a Large Tertiary Care Center with Low COVID-19 Incidence." International Journal of Environmental Research and Public Health 18, no. 8 (April 15, 2021): 4201. http://dx.doi.org/10.3390/ijerph18084201.
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Personal protective equipment and adherence to disinfection protocols are essential to prevent nosocomial severe acute respiratory syndrome coronavirus (SARS-CoV-2) transmission. Here, we evaluated infection control measures in a prospective longitudinal single-center study at the Vienna General Hospital, the biggest tertiary care center in Austria, with a structurally planned low SARS-CoV-2 exposure. SARS-CoV-2-specific antibodies were assessed by Abbott ARCHITECT chemiluminescent assay (CLIA) in 599 health care workers (HCWs) at the start of the SARS-CoV-2 epidemic in early April and two months later. Neutralization assay confirmed CLIA-positive samples. A structured questionnaire was completed at both visits assessing demographic parameters, family situation, travel history, occupational coronavirus disease 2019 (COVID-19) exposure, and personal protective equipment handling. At the first visit, 6 of 599 participants (1%) tested positive for SARS-CoV-2-specific antibodies. The seroprevalence increased to 1.5% (8/553) at the second visit and did not differ depending on the working environment. Unprotected SARS-CoV-2 exposure (p = 0.003), positively tested family members (p = 0.04), and travel history (p = 0.09) were more frequently reported by positively tested HCWs. Odds for COVID-19 related symptoms were highest for congestion or runny nose (p = 0.002) and altered taste or smell (p < 0.001). In conclusion, prevention strategies proved feasible in reducing the risk of transmission of SARS-CoV-2 from patients and among HCWs in a low incidence hospital, not exceeding the one described in the general population.
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Takizawa, Jun, Michaela Gruber, Ritsuro Suzuki, Naoya Nakamura, Gregor Hoermann, Leonhard Muellauer, Sadao Aoki, Junji Suzumiya, and Ulrich Jaeger. "Comparative Analysis of Japanese and European Typical CLL Patients." Blood 128, no. 22 (December 2, 2016): 5564. http://dx.doi.org/10.1182/blood.v128.22.5564.5564.
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Abstract Background: Chronic lymphocytic leukemia (CLL) is the most frequent leukemia in the Western countries but very rare in the East Asia including Japan. The previous reports from Japan showed that CLL patients in Japan have different characteristics including atypical morphology and immunophenotypes compared to those of Western countries. We started the cooperative study of CLL between Japan and Austria from 2012. Aim: The aim of this retrospective study is to compare the characteristics of typical CLL patients in Japan and Austria. Material and Methods: Diagnostic procedures were first harmonized between sites and laboratories. Samples were exchanged between Japan and Austria, and morphology, flow cytometry (FCM), FISH and IGVH gene sequence were independently assessed. After technical agreement, we selected 86 Austrian CLL patients from the database of the Medical University of Vienna, and 80 Japanese patients from the CLLRSG-01 prospective observational study. All CLL cases had typical immunophenotypes (Matutes score 4 or 5). The analyses of morphology, FCM and FISH including the deletion in 11q22, 13q14, and 17p13, and trisomy 12 were performed. Immunoglobulin heavy chain variable region (IGHV) gene mutation was also analysed. Results: Median age of CLL patients was 62.5 years old (range: 35-93) in Austria and 66.4 years (range: 34-93) in Japan. Japanese patients were significantly older at diagnosis than Austrian patients (P = 0.027). No differences were found for sex and the Binet stage. Also, there were no differences in laboratory findings (lymphocyte and platelet counts and serum LDH and beta-2-microglobulin levels) except for hemoglobin (Hb) level (median: 13.8g/dL in Austria vs. 13.1g/dL in Japan, P = 0.005) between two countries. Immunophenotypic study by FCM showed higher proportion of CD38 expression in Austrian CLL patients (34% in Austria vs. 10% in Japan, P < 0.001). No differences were found for chromosomal aberrations by FISH analyses between Austria and Japan. del(13q14) was found in 62% and 56% (P = 0.456), trisomy 12 in 7% and 13% (P = 0.315), del(11q22) in 13% and 10% (P = 0.513) and del(17p13) in 7% and 3% (P = 0.179), in Austria and Japan, respectively. The IGHV mutation rate was higher in Japan (P = 0.002). Mutated IGHV was found in 61% of Austrian and 84% of Japanese patients. IGHV family usage profile was significantly different. In Austrian patients, VH1, 2, 3, 4, 5, 6, and 7 were 24%, 1%, 54%, 19%, 1%, 1% and 0%, respectively. However, in Japanese patients, they were 2%, 0%, 75%, 20%, 2%, 0% and 2%, respectively. The proportion of VH1 was surprisingly lower in Japan (P = 0.006). Notably, none of the Japanese patients used VH1-69, in contrast to the use of 10% in Austrian patients. Conclusion : Our analysis indicates that there are clear differences between Japanese and European CLL patients, in age, Hb level, CD38 expression and IGHV usage and mutations. The reason for particular IGHV usage should further be investigated. Disclosures Takizawa: Teijin: Research Funding; Takeda: Honoraria, Research Funding; Celgene: Honoraria; Chugai: Honoraria, Research Funding; Kyowa Hakko Kirin: Honoraria, Research Funding; Janssen: Honoraria; Sumitomo Dainippon: Honoraria, Research Funding; MSD: Honoraria, Research Funding. Suzuki:Bristol-Myers Squibb: Honoraria; Kyowa Hakko kirin: Honoraria; Chugai: Honoraria. Hoermann:Gilead: Research Funding; Novartis: Honoraria; Amgen: Honoraria; Ariad: Honoraria. Aoki:SymBio Pharmaceuticals: Consultancy. Suzumiya:Kyowa Hakko kirin: Research Funding; Eisai: Honoraria, Research Funding; Astellas: Research Funding; Takeda: Honoraria; Toyama Chemical: Research Funding; Chugai: Honoraria, Research Funding. Jaeger:Janssen: Consultancy, Honoraria, Other: Travel, Accommodations, Expenses.
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UNOWSKY, DANIEL. "THE LAST YEARS OF THE HABSBURG MONARCHY Hitler's Vienna: a dictator's apprenticeship. By Brigitte Hamann. New York and Oxford: Oxford University Press, 1999. Pp. 512. ISBN 0-19-512537-1. £25.00. The undermining of Austria-Hungary: the battle for hearts and minds. By Mark Cornwall. Hampshire and London: Macmillan Press Ltd, 2000. Pp. 504. ISBN 0-333-80452-X. £57.50. The Habsburg Monarchy, c. 1765–1918: from enlightenment to eclipse. By Robin Okey. New York: St Martin's Press, 2001. Pp. 456. ISBN 0-312-23375-2. £55.50. The Jews of Vienna and the First World War. By David Rechter. London and Portland, OR: The Littman Library of Jewish Civilization, 2001. Pp. 232. ISBN 1-874774-65-X. £29.50. Reconstructing a national identity: the Jews of Habsburg Austria during World War I. By Marsha L. Rozenblit. Oxford and New York: Oxford University Press, 2001. Pp. 266. ISBN 0-19-513465-6. £47.50." Historical Journal 46, no. 2 (June 2003): 471–78. http://dx.doi.org/10.1017/s0018246x03003030.
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At least since Carl Schorske published Fin-de-siècle Vienna in 1981, the cultural explosion of Vienna 1900 has attracted the attention of scholars in many fields. Yet, the glittering imperial capital also incubated the Social Darwinian racist vision of Adolf Hitler, and Vienna's modern music, literature, and visual arts could not prevent the melting away of the Habsburg state at the close of the First World War. The five books under review explore the last years of the Habsburg Monarchy. The authors look beyond familiar topics, question basic scholarly assumptions, and provide fresh perspectives on the monarchy's final decade.
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Lubitz, Werner, and Bernd-Ulrich von Specht. "New Approaches in Vaccine Development, 1999 (NAVD’99, 15–18 May, 1999, Vienna, Austria) and New Approaches to Bacterial Vaccine Development (NABVD’99, 19–22 May 1999, Munich, Germany)." Journal of Biotechnology 83, no. 1-2 (September 2000): 1–2. http://dx.doi.org/10.1016/s0168-1656(00)00312-6.
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Murray, Robin, Christoph U. Correll, Gavin P. Reynolds, and David Taylor. "Atypical antipsychotics: recent research findings and applications to clinical practice: Proceedings of a symposium presented at the 29th Annual European College of Neuropsychopharmacology Congress, 19 September 2016, Vienna, Austria." Therapeutic Advances in Psychopharmacology 7, no. 1_suppl (March 2017): 1–14. http://dx.doi.org/10.1177/2045125317693200.
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Available evidence suggests that second-generation atypical antipsychotics are broadly similar to first-generation agents in terms of their efficacy, but may have a more favourable tolerability profile, primarily by being less likely to cause extrapyramidal symptoms. However, atypical antipsychotics are variably associated with disturbances in the cardiometabolic arena, including increased body weight and the development of metabolic syndrome, which may reflect differences in their receptor binding profiles. Effective management of schizophrenia must ensure that the physical health of patients is addressed together with their mental health. This should therefore involve consideration of the specific tolerability profiles of available agents and individualization of treatment to minimize the likelihood of adverse metabolic sequelae, thereby improving long-term adherence and optimizing overall treatment outcomes. Alongside this, modifiable risk factors (such as exercise, diet, obesity/body weight and smoking status) must be addressed, in order to optimize patients’ overall health and quality of life (QoL). In addition to antipsychotic-induced side effects, the clinical management of early nonresponders and psychopharmacological approaches for patients with treatment-resistant schizophrenia remain important unmet needs. Evidence suggests that antipsychotic response starts early in the course of treatment and that early nonresponse accurately predicts nonresponse over the longer term. Early nonresponse therefore represents an important modifiable risk factor for poor efficacy and effectiveness outcomes, since switching or augmenting antipsychotic treatment in patients showing early nonresponse has been shown to improve the likelihood of subsequent treatment outcomes. Recent evidence has also demonstrated that patients showing early nonresponse to treatment with lurasidone at 2 weeks may benefit from an increase in dose at this timepoint without compromising tolerability/safety. However, further research is required to determine whether these findings are generalizable to other antipsychotic agents.
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Sajko, K. "Recent Developments in International Arbitrability in Central Europe ("Aktuelles aus der Internationales Schiedsgerichtsbarkeit in Zentraleuropa") (International Court of Arbitration of the Austrian Chamber of Commerce) - 19-20 September 1996, Vienna (Austria)." Uniform Law Review - Revue de droit uniforme 2, no. 1 (January 1, 1997): 88–90. http://dx.doi.org/10.1093/ulr/2.1.88.
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Corrigall, R. "Generic models for use in assessing the impact of discharges of radioactive substances to the environment. IAEA Safety Reports Series No. 19. By IAEA, pp. 216, 2001 (IAEA, Vienna, Austria), €50.87." British Journal of Radiology 77, no. 916 (April 2004): 365. http://dx.doi.org/10.1259/bjr.77.916.770365b.
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Khlopova, A. I. "PSYCHOLINGUISTIC METHODS FOR ESTABLISHING THE BASE VALUE OF THE LEXEMЕ “ARBEIT” (WORK) IN AUSTRIAN LINGUISTIC CULTURE." Philology at MGIMO 19, no. 3 (October 3, 2019): 110–17. http://dx.doi.org/10.24833/2410-2423-2019-3-19-110-117.
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The article is devoted to the establishment of the socio-cultural content of the basic value “Arbeit”/ work in the Austrian linguistic culture. As the main method of establishing the socio-cultural content of the basic value, a free associative experiment was used. It was conducted with linguistic culture carriers from May to July in 2018 in Vienna, Klagenfurt, Villach, Linz, Salzburg. It was found that the psychologically relevant core of the basic value “Arbeit” / work confirms the socio-cultural content of the Austrian basic value. Austrian respondents’ nuclear reactions include: Freude / joy (9), Anerkennung / recognition (6), Stress / large amount of work (6), Erfolg / success (5), Motivation / motivation (4), Geld / money (3), Spaß / pleasure (3). The reactions that are part of the core of the lexemе’s value in the Austrian linguistic culture are rather positive. Work in general gives the Austrian respondents joy and pleasure. However, they mention a great amount of work. The associates unambiguously update the components of remuneration for work and the receipt of mental benefits. In the nuclear and individual responses of respondents, obtained on the basis of an associative experiment, social and cultural features of work in Austrian society are manifested: for the Austrians colleagues do play an important role, not the work itself, many Austrians want to be self-employed and work for themselves, female labor is lower paid in Austria than male work, Austrian workers are highly qualified, and students have a qualified education that they strive to improve, Austrians complain about Stress / a lot of work. The fact that the socio-cultural content is manifested in the reactions of the Austrians may indicate the correct establishment and relevance of the socio-cultural content of the basic value.
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Dorner, Thomas E., Franz Schwarz, Alexander Kranz, Wolfgang Freidl, Anita Rieder, and Christoph Gisinger. "Body mass index and the risk of infections in institutionalised geriatric patients." British Journal of Nutrition 103, no. 12 (March 8, 2010): 1830–35. http://dx.doi.org/10.1017/s0007114510000152.
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The objective was to examine the effect of BMI on the incidence of various infectious diseases in institutionalised, geriatric subjects. In a retrospective cohort study we analysed medical records of 619 patients aged 75 years and older (mean age 87·6 (sd 6·4) years) who were treated in a geriatric hospital in Vienna, Austria. The total incidence rate of infection in this population was 0·80 per person-year. The most frequent infections were urinary tract infections (0·30 per person-year), followed by infections of the lower respiratory tract (0·19 per person-year), diarrhoea (0·12 per person-year) and other infections (0·20 per person-year). Incidence risk ratios were obtained by a multiplicative Poisson regression model. There was a J-shaped curve in the incidence of infections recorded by BMI with a nadir at 27–28 kg/m2. Compared with the reference group with a BMI of 24–27·9 kg/m2, subjects with a lower BMI had a higher incidence rate of infections. The incidence risk ratios, adjusted for sex, age and chronic diseases, were 1·62 (95 % CI 1·21, 2·17) for those with a BMI of < 20 kg/m2 and 1·84 (95 % CI 1·40, 2·42) for those with a BMI of 20–23·9 kg/m2. However, also patients with a BMI of 28 kg/m2 and above had a higher incidence rate of infections, with an incidence risk ratio of 1·54 (95 % CI 1·07, 2·22). These results show that both underweight and obesity are associated with a higher risk of infections in institutionalised geriatric patients.
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Ettenauer, Jörg, Katja Sterflinger, and Guadalupe Piñar. "Cultivation and molecular monitoring of halophilic microorganisms inhabiting an extreme environment presented by a salt-attacked monument." International Journal of Astrobiology 9, no. 1 (December 15, 2009): 59–72. http://dx.doi.org/10.1017/s1473550409990383.
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AbstractIn the last few years several investigations, based on culture-dependent and -independent techniques, have shown that salt-attacked stone surfaces present a habitat for extremely salt tolerant and moderate halophilic microorganisms. The inner walls of the Chapel of St. Virgil in Vienna (Austria) are an example of this phenomenon. Salt crusts cover most of the wall surfaces and salt crystallization in the porous space of the stone is causing decohesion of material and destruction of the original medieval paintings. The salt, together with the oligotrophic conditions, creates a very special and extreme habitat for halotolerant and halophilic microorganisms.In this study we investigate and monitor the cultivable and non-cultivable members of the microbial community present on the stonework of the medieval Chapel of St. Virgil after several severe disturbances of the microbial environment caused by desalination and disinfection treatments. With this finality, a combination of culture-dependent and -independent techniques was selected. The genetic diversity of a total of 104 bacterial strains isolated from the stone samples was analysed by denaturing gradient gel electrophoresis (DGGE), random amplified polymorphic DNA (RAPD) analysis and 16S rRNA gene sequencing. Strains were distributed over 29 groups on the basis of their RAPD patterns. Only 19 groups were differentiated by DGGE. Comparative sequence analyses showed that the isolated strains belong to related species of the generaHalobacillus(47.1%),Bacillus(35.6%),Acinetobacter(4.8%),Halomonas(3.9%),Nesterenkonia(2.9%),Paucisalibacillus(2.9%),Paenibacillus(1%),Staphylococcus(1%) andExiguobacterium(1%).In addition, polymerase chain reaction DGGE fingerprints, in combination with the creation of clone libraries and sequencing analyses, were used to monitor and identifyArchaea, the non-cultivable fraction of the microbial community. The detected archaeal sequences were closely related to different uncultured archaeons as well as to the cultured generaHalococcusandHalalkalicoccusandHalobacterium.Cultivation and molecular analyses revealed the presence of highly specialized microorganisms that were able to thrive and survive after several desalination and disinfection treatments in the extreme environment presented by the salt-attacked Chapel of St. Virgil.
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Marcovina, Santica M., and John J. Albers. "Standardization of the Immunochemical Determination of Apolipoproteins A-I and B: A Report on the International Federation of Clinical Chemistry Meeting on Standardization of Apolipoprotein A-I and B Measurements (Basis for Future Consensus), Vienna, Austria, April 18-19, 1989." Clinical Chemistry 35, no. 9 (September 1, 1989): 2009–15. http://dx.doi.org/10.1093/clinchem/35.9.2009.
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Abstract The central aim of standardization is to have accurate, reproducible apo A-I and B measurements for use in defining a person's risk for cardiovascular disease or in evaluating a therapeutic response. A common accuracy-based standardization program is indispensable in establishing international reference intervals for clinical use. It is therefore important that the standardization be implemented as soon as possible. Many problems of the standardization of apo A-I and B measurements have been presented and discussed in this meeting. Although immediate solutions to all the problems were not evident, following the recommendations from this meeting can significantly improve the standardization process. The next step is to determine uniform reference intervals, followed by a consensus conference on apolipoproteins to define the cutpoints (cutoff values) for clinical decisions.
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de Laat, Bas, Johanna A. Kremer Hovinga, Wouter Pos, Evelyn Groot, Jing-Fei Dong, Bernard Lammle, Jan Voorberg, and Philip G. de Groot. "Beta2-Glycoprotein I: Implications for a Regulatory Role in Thrombotic Thrombocytopenic Purpura." Blood 110, no. 11 (November 16, 2007): 278. http://dx.doi.org/10.1182/blood.v110.11.278.278.
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Abstract Introduction: Thrombotic thrombocytopenic purpura (TTP) is serologically characterized by a severe deficiency of ADAMTS-13 (von Willebrand factor (vWF)-cleaving protease) activity and a pentad of clinical symptoms; thrombocytopenia, microangiopathic hemolytic anemia, neurological symptoms, renal dysfunction and fever. Due to the absence of ADAMTS-13 activity, ultra-large vWF multimers can be detected in plasma of TTP patients. It is thought that these ultra-large vWF-multimers have a more active (=platelet-binding) conformation than normal vWF-multimers. One of the poorly understood observations in TTP is that some patients have no ADAMTS-13 activity for years without suffering from TTP-related clinical symptoms. Apparently, there are additional factors that regulate the activity of vWF and thereby possibly influences disease activity in TTP patients. It was recently published that plasma protein beta2-glycoprotein I (b2GPI) binds activated vWF and thereby impairs its platelet binding capacity. Given the presence of large, active vWF multimers in TTP, we speculated on a role for b2GPI in acute TTP. Methods: In a population of 38 patients suffering from acute acquired TTP blood samples were drawn. ADAMTS-13 activity, ADAMTS-13 inhibitor levels, anti-ADAMTS-13 IgG titre (Technoclone, Vienna Austria) and b2GPI plasma concentration were measured. Furthermore, we tested the influence of b2GPI on platelet adhesion onto vWF under flow in a flow based-assay (as described by Dong et al., Blood. 2002;100:4033–9); Endothelial cells were stimulated with histamine and subsequently perfused with platelets in the presence/absence of b2GPI. Results: The median b2GPI plasma concentration in all 38 patients was significantly lower than in controls (87.6ug/ml +/− 7.7 vs 169.0ug/ml +/− 16.7, p=0.001). Furthermore, we found a significant difference in b2GPI plasma levels between patients with a high ADAMTS-13 inhibitor levels (bethesda titre > 3, n=19) and patients having low inhibitor levels (bethesda titre < 3, n=19) of 81.3ug/ml +/− 8.4 compared to 107.5ug/ml +/− 16.1 (p=0.03). In addition, a negative correlation with a trend towards significance was observed between the anti ADAMTS-13-IgG titre and the b2GPI plasma concentration (R=−0.28, p=0.09). In the flow-based assay, we found a concentration dependent inhibition of b2GPI on platelet adhesion. B2GPI coated beads bound directly to the freshly released vWF in a regular (string-like) pattern indicating specific binding of b2GPI to vWF. Conclusion: In this study, we show that b2GPI was able to inhibit platelet adhesion on freshly released VWF on endothelial cells. TTP patients seem to have lower b2GPI levels than healthy controls and the lowest levels were observed in the patient group with high functional ADAMTS-13 inhibitor titres. Together, our findings suggest that the inhibitory effect of b2GPI on vWF-platelet adhesion is attenuated in TTP possibly resulting in increased disease activity.
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Shelat, Suresh G., Paula Smith, Jihui Ai, and X. Long Zheng. "ADAMTS13 Autoantibodies, Antigen and Proteolytic Activity in Patients with Thrombotic Thrombocytopenic Purpura." Blood 106, no. 11 (November 16, 2005): 2642. http://dx.doi.org/10.1182/blood.v106.11.2642.2642.
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Abstract Many patients with thrombotic thrombocytopenic purpura (TTP) harbor autoantibodies against the ADAMTS13 protease, which can block proteolytic activity or accelerate clearance of this protease. The autoantibodies may be categorized as ‘inhibitory’ antibodies that bind and inhibit ADAMTS13 activity in vitro and ‘non-inhibitory’ antibodies that may bind, but do not affect the ADAMTS13 activity. The pathophysiologic role of two types of anti-ADAMTS13 autoantibodies on the level of ADAMTS13 antigen and activity remains unclear. To address this question, the relationship between the autoantibodies, and the levels of antigen and proteolytic activity in 40 patients with TTP (26 idiopathic and 14 non-idiopathic) was determined. The diagnosis of TTP was based on the presence of thrombocytopenia and microangiopathic hemolytic anemia with or without renal dysfunction and neurological symptoms. The ADAMTS13 antigen was determined by ELISA (American Diagnostica, Stamford CT). The ADAMTS13 autoantibodies were determined by Technozyme-ELISA (Technoclone GmbH, Vienna, Austria) and Immunoprecipitation and Western blotting. The ADAMTS13 activity was determined by Fluorescent resonance energy transfer (FRETS)-VWF73. The results showed that: 1) autoantibodies were present in 24 of 40 (60%) of all TTP patients, 19 of 26 (73%) in idiopathic TTP and 5 of 14 (36%) in non-idiopathic TTP. The prevalence of non-inhibitory autoantibodies was approximately 31% (8/26) in patients with idiopathic TTP and 36% (5/14) in patients with non-idiopathic TTP; 2) there was a positive correlation between the ADAMTS13 antigen levels and enzymatic activity in 36 samples tested (r=0.665, P<0.0001). This positive correlation was not altered even after removing from the analysis samples demonstrating inhibitors and low activity; 3) with respect to antigen levels, there was no significant difference between idiopathic vs. non-idiopathic TTP patients, whereas ADAMTS13 activity are significantly lower in the former (Table 1); 4) the inhibitory autoantibodies significantly reduce ADAMTS13 activity and may or may not decrease ADAMTS13 antigen levels. However, non-inhibitory autoantibodies neither decrease ADAMTS13 levels nor proteolytic activity (Table 2). We conclude that overall, in TTP patient samples, ADAMTS13 antigen levels correlate with activity. Subgroup analysis indicates that idiopathic and non-idiopathic TTP patients have similar ADAMTS13 antigen levels, whereas the former demonstrates much less proteolytic activity. TTP patients with inhibitory autoantibodies may have a more profound effect on ADAMTS13 activity (and perhaps also on clearance) than those with non-inhibitory autoantibodies. The non-inhibitory antibodies do not appear to accelerate ADAMTS13 protease clearance in vivo. Table 1. ADAMTS13 Antigen and Activity in Idiopathic and Non-Idiopathic TTP Patients Patients Antigen (ng/ml) Activity (%) * p < 0.05 Idiopathic 276 ± 46 (n=19) 16.9 ± 6 (n=21)* Non-idiopathic 328 ± 43 (n=17) 45.1 ± 5.7 (n=19) Table 2. Effect of Autoantibodies on ADAMTS13 Antigen and Activity Antibodies Definition Antigen (ng/ml) Activity (%) *p=0.085; **p < 0.05 vs "non-inhibitory" and <0.05 vs. "None" group Inhibitory Activity <10%, Inhibitor (1:1), positive, TecZym>15 U/ml 183 ± 55* 4.1 ± 1.2 (n=9)** Non-inhibitory Activity>10%, Inhibitor (1:1), negative, TecZym >15 U/ml 368 ± 52 37.6 ± 8 (n=17) None Activity >10%, Inhibitor (1:1), negative, TecZym <12 U/ml 294 ± 51 40.2 ± 7 (n=13)
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Lefteratou, Anna. "Nonnus of Panopolis in Context II: Poetry, Religion, and Society. Proceedings of the International Conference on Nonnus of Panopolis, 26‐19 September 2013, University of Vienna, Austria. Edited by Herbert Bannert and Nicole Kröll. Mnemosyne Supplements 408. Leiden, The Netherlands: Brill, 2018. Pp. xx+436, color ills. $140." Religious Studies Review 45, no. 1 (March 2019): 67. http://dx.doi.org/10.1111/rsr.13837.
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Iqbal, Zafar, Muhammad Absar, Abid Jameel, Tanveer Akhtar, Sulman Basit, Aamer Mahmood, Aamir Aleem, et al. "Investigations on Novel Gene Variants Associated with Longterm Response to Tyrosine Kinase Inhibitors (TKIs) in Chronic Myeloid Leukemia: Implication in TKI-Cessation Clinical Trails." Blood 134, Supplement_1 (November 13, 2019): 2939. http://dx.doi.org/10.1182/blood-2019-125518.
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Introduction: Tyrosine kinase inhibitor (TKIs) have revolutionized CML treatment causing more than 80% patients to achieve durable cytogenetic and molecular remissions1. Initial CML treatment guidelines were to keep CML patients on TKIs for the life time2. Nevertheless, cost issues related to TKI-based treatment have given rise to thinking if TKI treatment can de safely discontinued in a subset of long-term treatment CML responders2. This led to carry out STOP-TKI trials in long-term TKI responders in CML globally1-3. Such efforts can culminate into significant reduction of costs related to very expensive TKI treatment that can spare billions of US dollars annually for treatment and research related to other hematological disorders1. One of the hindrance for successful application of STOP-TKI efforts is lack of any molecular and other biological biomarkers in CML patients with long-term response as potential candidates for treatment discontinuation3.As next generation sequencing (NGS) technology has proved to be very useful in elucidating novel biomarkers in hematological and other disorders, this study was designed to find novel genetic variants associated with long-term imatinib response in our CML patients. Materials and Methods: Selection of Study Subjects (N=123): 1.Chronic phase treatment-naïve CML patients (Control 1) 2.Chronic phase CML long-term TKI responders (at least 3 continuous years of MMR)2 (Experimental group) 3.CML patients with resistant to TKIs (Control 2) 4.CML patients in accelerated and blast crisis phases (Control 3) 5.Healthy controls All patients were recruited from Hayatabad Medical Complex, Peshawar, Pakistan. Sample Collection and DNA extraction:10 ml peripheral blood was collected from all study subjects. DNA was extracted at HOPES, University of the Punjab, Lahore, Pakistan. Patient follow-up was carried out during course of this study (2013-8). Whole Exome Sequencing (WES): WES was carried out using Illumina NGS instrument (HiSeq). bcl files were converted to fastq files by using bcl2fastqtool 4. Raw reads were aligned to genome using BWA tools while whole exome variants were annotated using Illumina Variant Studio 4. R package was employed to align specific gene mutants to disease phenotypes 5. Variants detected by WES were confirmed using Sanger sequencing. Results & Discussion: Novel genes/variants associated exclusively with long-term CML responders to imatinib and absent in all control groups are provided in Table 1. One gene of particular interest is RA1 gene that had multiple frameshift mutations, active throughout the body and controls functions of many genes involved in daily rhythms6. Our studies are supported by some previous studies that reported CML patients with some genotypes (rs460089-GC in SLC22A4 gene) showing stable major molecular response 7. Clinical Significance: Variants found in this study can serve as biomarkers of long term response that can help identify candidates of cessation of TKIs which is one of the major focus of many ongoing CML STOP-TKI trials. References: 1.Saussele S,et al.Lancet Oncol. 2018 Jun;19(6):747-757. 2.Etienne G,et al. J Clin Oncol. 2017 Jan 20;35(3):298-305. 3.McMullan RR, McConville C, McMullin MF. Ulster Med J. 2019 May;88(2):105-110. 4.Hashmi JA, et al. 2018 Jan;58(1):10-15. 5.R Core Team (2012). R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. ISBN 3-900051-07-0, URL http://www.R-project.org/ 6.https://www.genecards.org 7.Jaruskova M. et al. J Exp Clin Cancer Res. 2017; 36: 55. Disclosures No relevant conflicts of interest to declare.
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Elstrott, Benjamin K., Sarah J. Nagle, Caleb Price, Luz Mejia-Flores, Nathan Beird, and H. E. Hinson. "Endothelial Injury Markers and Central Nervous System Damage-Associated Proteins in Immune Effector Cell-Associated Neurotoxicity Syndrome." Blood 136, Supplement 1 (November 5, 2020): 18–19. http://dx.doi.org/10.1182/blood-2020-139011.
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Introduction Immune effector cell-associated neurotoxicity syndrome (ICANS) is a neurologic syndrome that occurs in approximately 65% of adults undergoing CAR-T therapy for treatment of B-cell malignancies refractory to conventional chemotherapy. The presentation of ICANS is variable and sometimes progressive, including symptoms of headache, aphasia, seizure, cerebral edema, and coma. The exact mechanism of ICANS is unknown, but may be driven by cytokine release, endothelial activation, and blood-brain barrier disruption (BBBD). Prior studies show increases in angiopoietin 2 (ANG2) and lower angiopoietin 1 (ANG1) suggesting endothelial destabilization and consequent BBBD. It is not yet clear if cellular injury to the central nervous system (CNS) also occurs. Blood-based damage-associated protein biomarkers have shown promise in forecasting presence, severity, and prognostic outcomes following acute neurologic injuries such as traumatic brain injury, including S100 calcium binding protein B (S100b) and Ubiquitin carboxyl-terminal hydrolase L1 (UCH-L1). S100b is predominantly of astroglial origin and is established as a biomarker of secondary brain injury, while UCH-L1 is selectively expressed in neurons and reflects neuronal injury. Objective To characterize the relationship between the development of ICANS and plasma markers of inflammation, BBBD, and CNS cellular injury following CAR-T cell therapy. Methods We performed an interim analysis of an ongoing, prospectively enrolled cohort of adults receiving CD-19 targeted CAR-T therapy for hematologic malignancies. Blood samples are obtained at baseline prior to induction chemotherapy, and at 24-48 hours post-CAR-T infusion. Symptomatic samples are obtained when/if a patient develops ICANS as determined by interval screening using Immune Effector Cell-Associated Encephalopathy (ICE) scores, which assesses for the presence and severity of ICANS. Blood samples are centrifuged, aliquoted for plasma, and stored at -80° C. Markers of interest for this analysis were measured in batch by Luminex immunofluorescence, and included ANG1, ANG2, IL-6, S100b, and UCH-L1. Concentrations are reported in median [IQR] pg/mL. Parametric continuous variables were analyzed by independent two sample t-tests; Wilcoxon rank sum tests were used for non-parametric variables. Categorical variables were compared by chi-square tests. All analyses were conducted in R (R Core Team 2019, R Foundation for Statistical Computing, Vienna, Austria). Results The first 17 consecutive subjects (35% women) were included in this analysis in whom 8 (47%) developed ICANS. The most common diagnosis was diffuse large B-cell lymphoma (77%). No differences were observed in sex, race, ethnicity, and diagnosis categories between subjects who did and did not develop ICANS. All patients had baseline samples, however, only 14/17 patients had 24-48-hour samples, and only 2/8 patients with ICANS had symptomatic samples drawn. At baseline, there were no differences in median ANG1 (1172 [390-1609] v. 1651 [313-1910] pg/mL, P=0.96), ANG2 (1180 [732-1544] v. 1089 [592-2510] pg/mL, P=0.88) or ANG2/ANG1 ratio (P=0.96) between patients who later developed ICANS and those who did not. Similarly, there were no differences in baseline levels of IL-6 (2.6 [3.2-5.4] v. 1.5 [2.8-6.4] pg/mL, P=0.60) or S100b (0 [0-0] v. 0 [0-111] pg/mL, P=0.09) between ICANS groups. In the 2 patients who developed ICANS where symptomatic blood draws were obtained, both had precipitous rises in S100b from baseline to symptomatic levels (Case 1: 0 pg/mL ->153pg/mL, Case 2: 0 ->79 pg/mL) (Figure 1). Both of these patients died; one during acute hospitalization after CAR-T infusion while the other died 9 months after CAR-T due to cancer recurrence. UCH-L1 was below the detection limit in the plasma of all patients at all timepoints. Conclusions Our preliminary analysis suggests that baseline levels of inflammatory and endothelial permeability markers might be similar between those who do and do not develop ICANS after CAR-T infusion, and thus may not be informative about subsequent course. We also observed increases in the astrocytic marker S100b in symptomatic ICANS patients compared to baseline levels that appear to track with ICANS severity. In contrast, the neuronal marker UCH-L1 was undetectable in all patients. However, these observations must be confirmed in a larger cohort with complete data. Disclosures Hinson: Biogen (CHARM trial): Consultancy; Neurology (Journal): Other: Editorial Work; NIH NINDS Grant (1K23NS110828-01A1): Other: Grant funding TBI research (unrelated to present abstract).
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Guillaume-Jugnot, Perrine, Zora Marjanovic, Myriam Labopin, Louis Terriou, Christophe Deligny, Bruno Lioure, Thierry Martin, et al. "Autologous Hematopoietic Stem Cell Transplantation (AHSCT) in Severe Auto-Immune Disease Adult Patients: Analysis of Outcomes from the French Society for Bone Marrow Transplantation and Cellular Therapy (SFGMT-TC) in Light of the European Society for Blood and Marrow Transplantation (EBMT) Activity." Blood 126, no. 23 (December 3, 2015): 1985. http://dx.doi.org/10.1182/blood.v126.23.1985.1985.
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Abstract Introduction Autologous Hematopoietic Stem Cell transplantation (AHSCT) is used since 1994 worldwide to treat severe autoimmune disease (AD) refractory to standard therapy. Despite early release and regular update of the European Society for Blood and Marrow Transplantation (EBMT) practice guidelines (Snowden JA et al BMT 2012, Alexander T et al BMT 2014) along with 3 randomised Clinical trials (CTs) for Systemic Sclerosis (SSc) ASTIS, Crohn's Disease (CD) ASTIC and Multiple sclerosis (MS) ASTIMS, the uptake of this approach varies according to each ADs and between countries. We therefore design this retrospective study to evaluate patients (pts) outcomes as reported to the French Bone Marrow Transplantation Society registry (SFGMT-TC) in light of the other States activity published or reported to the EBMTregistry. Materials and methods All AHSCT for adult AD pts (> 18 years (yrs)) reported in France from 1997 to 2013 with at least one yr follow-up after AHSCT were included in the study. Primary data were derived from the EBMT registry (MED-A/B forms) with additional data obtained through a specific questionnaire (MED-C) for the study. Primary end point is overall survival (OS), defined as time since the day of transplant to death, irrespective of the cause. Secondary end points are Progression Free Survival (PFS), 100 day treatment related mortality (100-day TRM) and non-relapse related mortality (NRM). The probabilities were estimated using the Kaplan-Meier estimator for OS and PFS, cumulative incidence for NRM, relapse/progression being the competing event. All tests were two-sided. Statistical analyses were performed with IBM SPSS Statistics 22.0 and R version 3.1.2 (R Development Core Team, Vienna, Austria) software packages. Results 96 adult pts (55% Female), median age 45 yrs [20-71], underwent a first AHSCT for ADs in 19 HSCT Units. Most of the ADs were rheumatological(72%) with 55 SSc, 7 polymyositis-dermatomyositis, 3 polychondritis, 2 Lupus Erythematosus, 1 Rheumatoid Arthritis (RA), 1 Ankylosing Spondylitis, or neurological (15%) with 14 MS, whereas the others were 5 CDs, 5 immune thrombocytopenic purpura, 1 hemolytic autoimmune anemia, 1 IgM neuropathy and 1 POEMS syndrome. Two pts had 2 simultaneous ADs (1 SSc and RA, 1 CD and RA). Median duration between AD diagnosis and AHSCT was 3.5 yrs [1-33]. With a median follow-up of 7 yrs [<1- 17], 5 yrs OS and PFS were 79.4% [95% CI: 70.8-88] and 49.3% [95% CI: 38.7-59.9] while 10 yrs OS and PFS were 70.2% [95% CI: 58.9-81.7] and 41.9 % [95% CI: 30.6-53.2], respectively. The 100 days NRM was 7.4% [95% CI: 3.2-13.9]. 5 and 10 yrs NRM was 9.6% [95% CI: 4.7-16.6] and 13.6% [95% CI: 6.9-22.7] respectively. At the end of follow-up, 28 pts (29%) had died, for whom the causes of death were: relapse or progression (n=12), AHSCT related cause (n=7 with 3 infections, 2 cardiac toxicity, 1 renal toxicity, 1 respiratory failure), secondary malignancies (n=3), aspiration pneumonia in polychondritis (n=1) or unknown causes (n= 5). Conclusion AHSCT for severe ADs, has progressively developed in France, allowing 5y OS equal to 79.4%, similar to UK (Snowden JA et al, BJH 2012) and EBMT data. In rapidly progressive severe SSc, where the proof of efficacy of AHSCT was obtained (Van Laar J and Farge D et al, JAMA 2014) and in MS (Pasquini MC et al BBMT 2010) where long-term responses are confirmed worldwide, the French and the EBMT registry activities have increased over the past 14 years, with sustained positive clinical results despite non negligible NMR, which remains lower than spontaneous AD evolution. Meanwhile, AHSCT activity has become exceptional in RA due to the availability of safe and effective biological therapies, and other indications remain rare, such as for CD or SLE where the risk of AHSCT in highly immunosuppressed patients has to be balanced with ADs severity. More than half of French pts were treated on an individual basis, outside CTs, underlying the need to evaluate national activity and to promote education of HSCT Unit members. At each French or other European state levels, like in the US, the indications for AHSCT in ADs remain low due to other competing therapies. Combined study using European and American data registry will allow analysis of a larger number of AD pts treated by AHSCT and would offer more clues to better understand the determinants of the response and to refine indications for each AD type. Disclosures Leblond: Gilead: Consultancy, Honoraria, Speakers Bureau; Janssen: Consultancy, Honoraria, Speakers Bureau; Roche: Consultancy, Honoraria, Other: Travel, Accommodations, Expenses, Speakers Bureau; GSK: Consultancy, Honoraria, Speakers Bureau; Mundipharma: Honoraria. Snowden:MSD: Consultancy, Other: Educational support, Speakers Bureau; Janssen: Other: Educational support, Speakers Bureau; Celgene: Other: Educational support, Speakers Bureau; Sanofi: Consultancy.
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Terpos, Evangelos, Dimitrios Christoulas, Maria Gkotzamanidou, Cornelia Bratengeier, Maria Gavriatopoulou, Magdalini Migkou, Athanasios Papatheodorou, Efstathios Kastritis, Wolfgang Woloszczuk, and Meletios A. Dimopoulos. "Circulating Levels of the Wnt Inhibitors Dickkopf-1 and Sclerostin In Different Phases of Multiple Myeloma: Alterations Post-Therapy with Lenalidomide and Dexamethasone with or without Bortezomib." Blood 116, no. 21 (November 19, 2010): 2963. http://dx.doi.org/10.1182/blood.v116.21.2963.2963.
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Abstract Abstract 2963 Dickkopf-1 (Dkk-1) and sclerostin are inhibitors of the Wingless-type and integrase 1 (Wnt) signaling and they are implicated in the pathogenesis of multiple myeloma (MM) bone disease through inhibition of osteoblast function. There is very limited information for the circulating levels of Dkk-1 and sclerostin in different phases of MM and their alterations post therapies with novel agents. Therefore, we studied 284 MM patients (153M/131F, median age 66 years): 167 consecutive patients were newly-diagnosed (20 had asymptomatic MM and 147 symptomatic MM), 29 patients were at the plateau phase of MM and 88 patients had relapsed/refractory MM and received therapy with the combination of lenalidomide plus dexamethasone with or without bortezomib (VRD or RD; Dimopoulos et al, Leukemia 2010). For newly diagnosed patients, serum was stored at the time of diagnosis, while for patients at the plateau phase serum was collected at the time of confirmation of the plateau (at least 6 months with stable M-protein without criteria confirming progression) and for relapsed/refractory patients on day 1 of cycles 1, 4 and 7 of VRD or RD administration. Circulating levels of Dkk-1 and sclerostin were measured using ELISA methodology (R&D Systems, Minneapolis, MN, USA and Biomedica Medizinprodukte, Vienna, Austria, respectively) in all patients and in 20 gender- and age- matched healthy controls. Circulating Dkk-1 and sclerostin concentrations of newly diagnosed symptomatic patients (median: 1383 pg/mL, range:274-32, 862 pg/mL and 415 pg/mL, 0–3,340 pg/mL respectively) were increased compared to controls (1069 pg/mL, 540-2, 709 pg/mL; p<0.001 and 250 pg/mL, 0–720 pg/mL; p=0.03, respectively) and to asymptomatic patients at diagnosis (1044 pg/mL, 480-2, 335 pg/mL; p<0.001 and 140 pg/mL, 0–1,100 pg/mL; p=0.001, respectively). Patients at plateau phase had increased circulating levels of sclerostin (704 pg/mL, 68–2000 pg/mL; p <0.001) compared to controls (p=0.002) as well as to MM patients at diagnosis (p=0.02). In contrast, they had lower serum levels of Dkk-1 (1013 pg/mL, 414–1729 pg/mL) compared to MM patients at diagnosis (p<0.001) and no difference compared to controls. Patients with ISS-3 myeloma at diagnosis had higher values of Dkk-1 and sclerostin than ISS-1 and ISS-2 patients [median Dkk-1 values for ISS-1, ISS-2 and ISS-3 were: 1059 pg/mL, 1290 pg/mL and 2649 pg/mL, respectively; p(ANOVA)=0.031; median sclerostin values for ISS-1, ISS-2 and ISS-3 were: 394 pg/mL, 392 pg/mL and 714 pg/mL, respectively; p(ANOVA)=0.001]. Patients with lytic disease at diagnosis (n=116) had increased levels of Dkk-1 compared with patients with no lytic disease (n=51): 1475 pg/mL, 327-32, 862 pg/mL vs. 840 pg/mL, 274–1112 pg/mL; p=0.002. There was no difference in sclerostin levels between these patients; however, patients with advanced bone disease (>3 lytic lesions and/or a fracture) had a borderline increase in their circulating sclerostin compared to all others (p=0.072). Dkk-1 circulating levels correlated weakly with sclerostin (r=0.201, p=0.05). Relapsed patients had increased Dkk-1 (1218 pg/mL, 161-19, 325 pg/mL) and sclerostin (886 pg/mL, 90-6, 272 pg/mL) levels compared to controls and to asymptomatic patients at diagnosis (p<0.001 for all comparisons). In patients who received RD, Dkk-1 was increased and sclerostin was decreased after 6 cycles of therapy. Responders to RD had a median increase of 9% in Dkk-1 serum levels after 6 cycles of therapy, while non-responders had a median increase of 91% compared to baseline values (p<0.01). Patients who did not respond to RD showed an increase in bone resorption marker CTX (p=0.021) after 6 cycles of therapy. VRD administration resulted in a significant reduction of sRANKL (p=0.024) and increase of bone formation marker, osteocalcin (p=0.01) after 6 cycles, but showed only minimal reduction of Dkk-1 (p=0.08) and no alterations on sclerostin. In conclusion our study suggests that Dkk-1 is elevated in active myeloma, while sclerostin is elevated even in the plateau phase of the disease. Both correlated with adverse disease features. The increase of Dkk-1 by RD seems to be balanced by a reduction effect of bortezomib on Dkk-1 in VRD. Furthermore, the reduction of sclerostin in RD patients may represent a modulatory effect of lenalidomide on marrow microenvironment. These results further support the rationale for the use of drugs targeting Dkk-1 and sclerostin in MM. Disclosures: No relevant conflicts of interest to declare.
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Yamaguchi, Mirian Ueda, Josiane Kelly de Barros, Rosane Clys de Barros Souza, Marcelo Picinin Bernuci, and Leonardo Pestillo de Oliveira. "O papel das mídias digitais e da literacia digital na educação não-formal em saúde (The role of digital media and digital literacy in non-formal health education)." Revista Eletrônica de Educação 14 (January 15, 2020): 3761017. http://dx.doi.org/10.14244/198271993761.
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Digital health literacy involves the individual's ability to effectively interpret, evaluate and use health information obtained through digital media, enabling them to make decisions and have greater autonomy over their health. Considering the increasing use of digital media as a source of health information for the population, the present study aimed to evaluate the digital health literacy level of individuals who use social media. The study was conducted with a sample of 423 individuals using a digital questionnaire to obtain socioeconomic data, and the eHealth literacy scale (eHeals) instrument was used to assess the level of digital health literacy. The results indicated that higher levels of education and income correlate with higher levels of digital health literacy. The biological determinants of age and gender did not correlate with digital literacy. It is concluded that government strategies that seek to use social media such as Facebook, Instagram and Twiter as an alternative to non-formal health education should consider that the success of these strategies depends on first investing in the formal education of the population.ResumoLiteracia digital em saúde envolve a capacidade do indivíduo em interpretar, avaliar e usar de forma eficaz as informações de saúde obtidas por meio das mídias digitais, permitindo-o tomar decisões e ter maior autonomia sobre sua saúde. Considerando a crescente utilização das mídias digitais como fonte de informações em saúde para população, o presente estudo objetivou avaliar o nível de literacia digital em saúde de indivíduos que fazem uso das mídias digitais. O estudo foi desenvolvido com uma amostra de 423 indivíduos por meio de questionário digital para obtenção de dados socioeconômicos e o instrumento eHealth literacy scale (eHeals) foi utilizado para avaliar o nível de literacia digital em saúde. Os resultados indicaram que maior nível de escolaridade e renda correlaciona com maiores níveis de literacia digital em saúde. Os determinantes biológicos idade e sexo não apresentaram correlação com a literacia digital. Conclui-se que a estratégia do governo que busca, por exemplo, utilizar as redes sociais online Facebook, Instagram e Twiter como alternativa de educação não-formal em saúde deve considerar que o êxito dessa estratégia perpassa pela necessidade de investir na educação formal.Palavras-chave: Educação não-formal, Educação para saúde, Política de saúde.Keywords: Non-formal education, Health education, Health policy.ReferencesBARROS, Josiane Kelly. Adaptação transcultural e análise das propriedades psicométricas de instrumento para avaliação da literacia digital em saúde. 2019. 77 f.. Dissertação (Mestrado em Promoção da Saúde) – Centro Universitário de Maringá – UNICESUMAR, Maringá, 2019.BIRCH, David. Improving schools, improving school education health education, improving public health: The role of SOPHE members. Health Education & Behavior, v. 44, n. 6, p. 839-844, 2017. http://dx.doi: 10.1177/1090198117736353.Cohen, Jacob. Statistical Power Analysis. Current Directions in Psychological Science. v.1, n.3, p. 98–101, 1992. https://doi.org/10.1111/1467-8721.ep10768783DINO. 62% da População Brasileira está Ativa nas Redes Sociais. Disponível em: <https://exame.abril.com.br/negocios/dino/62-da-populacao-brasileira-esta-ativa-nas-redes-sociais/>. Acesso em: 22 setembro 2019.GABARRON, Elia; ARSAND, Eirik; WYNN, Rolf. Social Media Use in Interventions for Diabetes: Rapid Evidence-Based Review. Journal of Medical Internet Research. v. 10, n.11, 2018, e-10303. https://doi: 10.2196/10303Guntzviller, Lisa; King, Andy; Jensen, Jacob; Davis. Self-Efficacy, Health Literacy, and Nutrition and Exercise Behaviors in a Low-Income, Hispanic Population. Journal of Immigrant and Minority Health, v. 19, n. 2, p. 489–49, 2016. http://dx.doi:10.1007/s10903-016-0384-4 HSU, Michelle; ROUF, Anika; ALLMAN-FARINELLI, Margaret. Effectiveness and Behavioral Mechanisms of Social Media Interventions for Positive Nutrition Behaviors in Adolescents: A Systematic Review. Journal of Adolescent Health. v.63, n.5, p.531-545, 2018.IBGE – Instituto Brasileiro de Geografia e Estatística. Diretoria de Pesquisas, Coordenação de Trabalho e Rendimento, Pesquisa Nacional por Amostra de Domicílios Contínua 2016/2018. LaBARGE, Gene; BROOM, Matt. Social Media in Primary Care. Missouri Medicine. v. 116, n.2, 2019, p.106-110.Loureiro, Luís Manuel de Jesus; Gameiro, Manuel Gonçalves Henriques. Critical interpretation of statistical results: beyond statistical significance. Revista de Enfermagem Referencia, v.3, p 151-162, 2011.MERCHANT, Raina; ASCH, David. Protecting the Value of Medical Science in the Age of Social Media and “Fake News”. JAMA Network. v.320, n.23, p.2415-2416, 2018.MORAIS, José; KOLINSKY, Régine Kolinsky. Literacia científica: leitura e produção de textos científicos. Educar em Revista, n. 62, p.143-162, 2016. http://dx.doi.org/10.1590/0104-4060.48025.MOREIRA, Flávia Moraes.; PINHEIRO, Marta Macedo Kerr. Ministério da Saúde no facebook: um estudo de caso da política de informação. Informação & Informação, v. 20, n. 3, p. 147–174, 2015.MS. Ministério da Saúde. Disponível em: <http://bvsms.saude.gov.br/bvs/saudelegis/gm/2015/prt0589_20_05_2015.html>. Acesso em: 23 setembro 2019.MUKAKA, M. M. Statistics corner: A guide to appropriate use of correlation coefficient in medical research. 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Hill, G. N., W. R. Henshall, and R. M. Beresford. "Manipulating rainfall to study symptom expression of Botrytis cinerea infection in wine grapes." New Zealand Plant Protection 70 (July 26, 2017): 301–9. http://dx.doi.org/10.30843/nzpp.2017.70.64.
Full textAbstract:
Botrytis cinerea infection of wine grapes can result in a variety of symptoms. The most common symptom is botrytis bunch rot (BBR), where infected berries rot and shrivel, and eventually produce fungal sporulation. Another symptom is slip skin, where the skins of infected ripe berries slide easily from the pulp. It is hypothesised that a reduction in osmotic potential in grape berries due to late-season rainfall leads to slip skin symptom development. Hyphal growth of B. cinerea on osmotically adjusted agar was inhibited at osmotic potentials associated with near-ripe berries. Vine sheltering was used in a research vineyard to manipulate rainfall artificially and to alter berry sugar content in Vitis vinifera Sauvignon blanc vines, with the aim of increasing osmotic potential and altering symptom expression. Both BBR and slip skin symptoms were affected by the various sheltering conditions, with sheltered vines having lower BBR and higher slip skin at harvest.
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Can Gio mangrove forest (CGM) is located downstream of Ho Chi Minh City (HCMC), situated between an estuarine system of Dong Nai - Sai Gon river and a part of Vam Co river. The CGM is the largest restored mangrove forest in Vietnam and the UNESCO’s Mangrove Biosphere Reserve. The CGM has been gradually facing to numeric challenges of global climate change, environmental degradation and socio-economic development for the last decades. To evaluate sediment quality in the CGM, we collected 13 cores to analyze for sediment grain size, organic matter content, and trace element concentration of Cd, Cr, Cu, Ni, Pb, Zn. Results showed that trace element concentrations ranged from uncontaminated (Cd, Cu, and Zn) to very minor contaminated (Cr, Ni, and Pb). The concentrations were gradually influenced by suspended particle size and the mangrove plants.ReferencesAnh M.T., Chi D.H., Vinh N.N., Loan T.T., Triet L.M., Slootenb K.B.-V., Tarradellas J., 2003. 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"The International Liver CongressTM, Vienna, Austria, 2019." Journal of Hepatology 70, no. 5 (May 2019): ii. http://dx.doi.org/10.1016/s0168-8278(19)30083-2.
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Kurz, Herbert, and Tomas Gombala. "Multisystem Inflammatory Syndrome in Children (MIS-C)—A Case Series in December 2020 in Vienna, Austria." Frontiers in Pediatrics 9 (June 10, 2021). http://dx.doi.org/10.3389/fped.2021.656768.
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MIS-C is a novel clinical syndrome in children and adolescents, was first encountered in the spring of 2020 as a post COVID-19 multisystem inflammatory syndrome. The highest number of SARS-CoV-2 infections in Austria were registered in November 2020. In December 2020, eight patients with MIS-C were hospitalized at the pediatric department of Klinik Donaustadt, a large municipal hospital in Vienna. Six of the patients needed pediatric intensive care. As we lack any international consensus on the diagnosis and treatment of this severe complication, we used a multidisciplinary approach. The purpose was to establish an internal standard for maximizing the efficacy and safety of treatment, and standardizing the clinical management of this disease.
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Pawelka, Erich, Mario Karolyi, Theresa Mader, Sara Omid, Hasan Kelani, Sebastian Baumgartner, Sarah Ely, et al. "COVID-19 is not “just another flu”: a real-life comparison of severe COVID-19 and influenza in hospitalized patients in Vienna, Austria." Infection, May 13, 2021. http://dx.doi.org/10.1007/s15010-021-01610-z.
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