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Journal articles on the topic 'Bundibugyo'

Author: Grafiati

Published: 7 June 2025

Last updated: 17 July 2025

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1

Julius, Mwijuka Kiplangat, Andrew Peters Yigga, and Joyce Bukirwa Rebecca. "Therapeutic Painting and Sexual Violence Expressed by Students in Selected Secondary Schools in Bundibugyo District in Uganda." East African Journal of Arts and Social Sciences 7, no. 1 (2024): 36–45. http://dx.doi.org/10.37284/eajass.7.1.1724.

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Sexual violence has often caused distress to many people, and a lot has been written proposing solutions to this vice. Restoring hope among people who have been affected by sexual violence in Secondary schools in Bundibugyo District requires concerted effort and adopting ways that help to relieve the affected people of stress resulting from their experience with sexual violence. The current study focused on how therapeutic painting can be utilised to describe in detail lived experiences relating to ever-increasing sexual violence in secondary schools in the Bundibugyo district. Despite the var

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2

Bwambale, Blasio Bisereko, Godfrey Sseremba, Zami Atibuni, and Ssali Bisaso. "Impact of Different Agro-Forestry Systems on Cocoa Diseases among Smallholder Farmers in Bundibugyo District – Western Uganda." East African Journal of Forestry and Agroforestry 8, no. 1 (2025): 62–79. https://doi.org/10.37284/eajfa.8.1.2777.

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The Cocoa Agroforestry system integrates cocoa with high-value tree species and crops, providing additional income for farmers. In the Bundibugyo district, where cocoa is a primary livelihood, recent declines in cocoa production have been linked to diseases. This study evaluated the impact of various Agroforestry systems on cocoa diseases among smallholder farmers in Bundibugyo. Data were collected from four administrative units using a cross-sectional design with purposive sampling of 92 respondents. Household interviews, questionnaires, photographs, data sheets, and observations enriched the

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3

MacNeil, A., E. C. Farnon, O. W. Morgan, et al. "Filovirus Outbreak Detection and Surveillance: Lessons From Bundibugyo." Journal of Infectious Diseases 204, suppl 3 (2011): S761—S767. http://dx.doi.org/10.1093/infdis/jir294.

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4

Sizikova, T. E., V. N. Lebedev, N. V. Karulina, O. V. Chukhralya, S. I. Syromyatnikova, and S. V. Borisevich. "A SOME ECOLOGICAL CHARACTERISTICS OF EBOLA VIRUS IN NATURAL FOCIES." Journal of microbiology epidemiology immunobiology, no. 2 (April 28, 2018): 119–26. http://dx.doi.org/10.36233/0372-9311-2018-2-119-126.

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Ebola virus that composed Ebolavirus genus of Filoviridae Family causes severe hemorrhagic fever in humans with high case-fatality rates (up to 90%). The Ebolavirus genus includes Ebola-Zaire, Ebola-Sudan, Ebola-Reston, Ebola-Tai Forest and Ebola-Bundibugyo viruses. The date about epidemic outbreaks of disease, reservoirs of infection, accidental hosts of Ebola virus are presented in this review. The date about natural reservoirs of infection are accessed only for Ebola-Zaire and Ebola-Reston viruses. For Ebola-Sudan, Ebola-Tai Forest and Ebola-Bundibugyo viruses such information is absence. T

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5

Hulseberg, Christine E., Raina Kumar, Nicholas Di Paola, et al. "Molecular analysis of the 2012 Bundibugyo virus disease outbreak." Cell Reports Medicine 2, no. 8 (2021): 100351. http://dx.doi.org/10.1016/j.xcrm.2021.100351.

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6

Thembo, Moses, Maureen Andinda, Antony Ikiriza, Miisa Nanyingi, and Mathias Lwenge. "Factors associated with the utilization of contraceptives among teenagers in western Uganda: a cross-sectional study." NEWPORT INTERNATIONAL JOURNAL OF PUBLIC HEALTH AND PHARMACY 5, no. 3 (2024): 87–97. http://dx.doi.org/10.59298/nijpp/2024/538797.

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Teenage pregnancy continues to be a significant public health concern in Uganda, with approximately one thousand cases reported daily. The lack of access to and underutilization of contraceptives contribute to this issue. We aimed to investigate the factors associated with the utilization of contraceptives among teenagers. This cross-sectional study collected data on socio-demographics, health facility-related factors, access to contraceptive information and contraceptive utilization from 409 teenagers aged 13–19 years in Ntandi Town Council in Bundibugyo, western Uganda. Prevalence ratios (PR

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7

Albariño, C. G., T. Shoemaker, M. L. Khristova, et al. "Genomic analysis of filoviruses associated with four viral hemorrhagic fever outbreaks in Uganda and the Democratic Republic of the Congo in 2012." Virology 442, no. 2 (2013): 97–100. https://doi.org/10.5281/zenodo.13531217.

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(Uploaded by Plazi for the Bat Literature Project) In 2012, an unprecedented number of four distinct, partially overlapping filovirus-associated viral hemorrhagic fever outbreaks were detected in equatorial Africa. Analysis of complete virus genome sequences confirmed the reemergence of Sudan virus and Marburg virus in Uganda, and the first emergence of Bundibugyo virus in the Democratic Republic of the Congo.

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8

Albariño, C. G., T. Shoemaker, M. L. Khristova, et al. "Genomic analysis of filoviruses associated with four viral hemorrhagic fever outbreaks in Uganda and the Democratic Republic of the Congo in 2012." Virology 442, no. 2 (2013): 97–100. https://doi.org/10.5281/zenodo.13531217.

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(Uploaded by Plazi for the Bat Literature Project) In 2012, an unprecedented number of four distinct, partially overlapping filovirus-associated viral hemorrhagic fever outbreaks were detected in equatorial Africa. Analysis of complete virus genome sequences confirmed the reemergence of Sudan virus and Marburg virus in Uganda, and the first emergence of Bundibugyo virus in the Democratic Republic of the Congo.

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9

Mire, Chad E., Joan B. Geisbert, Andrea Marzi, Krystle N. Agans, Heinz Feldmann, and Thomas W. Geisbert. "Vesicular Stomatitis Virus-Based Vaccines Protect Nonhuman Primates against Bundibugyo ebolavirus." PLoS Neglected Tropical Diseases 7, no. 12 (2013): e2600. http://dx.doi.org/10.1371/journal.pntd.0002600.

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10

Arivuselvam, Rajaguru, A. Mohamed Sheik Tharik, S. B. Santhosh, S. N. Meyyanathan, and Raman Rajeshkumar. "In silico designed novel multi epitope vaccine construct towards Bundibugyo Ebolavirus." Vacunas (English Edition) 23, no. 3 (2022): 194–207. http://dx.doi.org/10.1016/j.vacune.2022.11.004.

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11

LI, Y. H., and S. P. CHEN. "Evolutionary history of Ebola virus." Epidemiology and Infection 142, no. 6 (2013): 1138–45. http://dx.doi.org/10.1017/s0950268813002215.

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SUMMARYSince Ebola virus was discovered in 1970s, the virus has persisted in Africa and sporadic fatal outbreaks in humans and non-human primates have been reported. However, the evolutionary history of Ebola virus remains unclear. In this study, 27 Ebola virus strains with complete glycoprotein genes, including five species (Zaire, Sudan, Reston, Tai Forest, Bundibugyo), were analysed. Here, we propose a hypothesis of the evolutionary history of Ebola virus which will be helpful to investigate the molecular evolution of these viruses.

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12

Kankya, Clovice, Daisy Nabadda, Consolata Kabonesa, et al. "Social Dynamics of Ebola Virus Disease: A Case of Bundibugyo District, Uganda." Health 11, no. 01 (2019): 108–28. http://dx.doi.org/10.4236/health.2019.111011.

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13

MacNeil, Adam, Eileen C. Farnon, Joseph Wamala, et al. "Proportion of Deaths and Clinical Features in Bundibugyo Ebola Virus Infection, Uganda." Emerging Infectious Diseases 16, no. 12 (2010): 1969–72. http://dx.doi.org/10.3201/eid1612.100627.

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14

Fosca, Wasswa Rodrick. "Understanding the Influential Factors of Teenage Pregnancy in Kirumya Sub-county, Bundibugyo District, Western Uganda." IAA Journal of Applied Sciences 10, no. 1 (2023): 100–113. http://dx.doi.org/10.59298/iaajas/2023/8.1.1000.

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Teenage pregnancy remains a pressing global concern, impacting public health and development on multiple fronts. This study focused on probing the specific factors contributing to teenage pregnancy in Kirumya sub-county, Bundibugyo District, in western Uganda. Its objectives centered on determining the prevalence of teenage pregnancy, identifying key contributing factors, and highlighting the challenges faced by adolescents contending with early pregnancies. Engaging fifty teenage mothers and drawing insights from ten key informants, the study employed face-to-face individual interviews and Fo

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15

Bramble, Matthew S., Nicole Hoff, Pavlo Gilchuk, et al. "Pan-Filovirus Serum Neutralizing Antibodies in a Subset of Congolese Ebolavirus Infection Survivors." Journal of Infectious Diseases 218, no. 12 (2018): 1929–36. https://doi.org/10.5281/zenodo.13533884.

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(Uploaded by Plazi for the Bat Literature Project) Infection with Zaire ebolavirus (EBOV) appears to trigger an anti–pan-filovirus response in a small subset of Congolese Ebola virus disease survivors, generating potential neutralizing antibodies against EBOV and Bundibugyo, Taï Forest, Sudan, and Marburg viruses., One year after a Zaire ebolavirus (EBOV) outbreak occurred in the Boende Health Zone of the Democratic Republic of the Congo during 2014, we sought to determine the breadth of immune response against diverse filoviruses including EBOV, Bundibugyo (BDBV), Sudan (SUDV), and Marburg (M

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16

Bramble, Matthew S., Nicole Hoff, Pavlo Gilchuk, et al. "Pan-Filovirus Serum Neutralizing Antibodies in a Subset of Congolese Ebolavirus Infection Survivors." Journal of Infectious Diseases 218, no. 12 (2018): 1929–36. https://doi.org/10.5281/zenodo.13533884.

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(Uploaded by Plazi for the Bat Literature Project) Infection with Zaire ebolavirus (EBOV) appears to trigger an anti–pan-filovirus response in a small subset of Congolese Ebola virus disease survivors, generating potential neutralizing antibodies against EBOV and Bundibugyo, Taï Forest, Sudan, and Marburg viruses., One year after a Zaire ebolavirus (EBOV) outbreak occurred in the Boende Health Zone of the Democratic Republic of the Congo during 2014, we sought to determine the breadth of immune response against diverse filoviruses including EBOV, Bundibugyo (BDBV), Sudan (SUDV), and Marburg (M

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17

Li, Y. H., and S. P. Chen. "Evolutionary history of Ebola virus." Epidemiology & Infection 142, no. 6 (2014): 1138–45. https://doi.org/10.5281/zenodo.13531293.

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(Uploaded by Plazi for the Bat Literature Project) Since Ebola virus was discovered in 1970s, the virus has persisted in Africa and sporadic fatal outbreaks in humans and non-human primates have been reported. However, the evolutionary history of Ebola virus remains unclear. In this study, 27 Ebola virus strains with complete glycoprotein genes, including five species (Zaire, Sudan, Reston, Tai Forest, Bundibugyo), were analysed. Here, we propose a hypothesis of the evolutionary history of Ebola virus which will be helpful to investigate the molecular evolution of these viruses.

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18

Li, Y. H., and S. P. Chen. "Evolutionary history of Ebola virus." Epidemiology & Infection 142, no. 6 (2014): 1138–45. https://doi.org/10.5281/zenodo.13531293.

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Abstract:

(Uploaded by Plazi for the Bat Literature Project) Since Ebola virus was discovered in 1970s, the virus has persisted in Africa and sporadic fatal outbreaks in humans and non-human primates have been reported. However, the evolutionary history of Ebola virus remains unclear. In this study, 27 Ebola virus strains with complete glycoprotein genes, including five species (Zaire, Sudan, Reston, Tai Forest, Bundibugyo), were analysed. Here, we propose a hypothesis of the evolutionary history of Ebola virus which will be helpful to investigate the molecular evolution of these viruses.

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19

Gilchuk, Pavlo, Chad E. Mire, Joan B. Geisbert, et al. "Efficacy of Human Monoclonal Antibody Monotherapy Against Bundibugyo Virus Infection in Nonhuman Primates." Journal of Infectious Diseases 218, suppl_5 (2018): S565—S573. http://dx.doi.org/10.1093/infdis/jiy295.

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20

Gupta, Manisha, Adam MacNeil, Zachary D. Reed, Pierre E. Rollin, and Christina F. Spiropoulou. "Serology and cytokine profiles in patients infected with the newly discovered Bundibugyo ebolavirus." Virology 423, no. 2 (2012): 119–24. http://dx.doi.org/10.1016/j.virol.2011.11.027.

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21

Oryem-Origa, H., E. K. Z. Kakudidi, A. B. Katande, and Z. R. Bukenya. "Preliminary ethnobotanical studies of the Rwenzori Mountain forest area in Bundibugyo District, Uganda." Bothalia 25, no. 1 (1995): 111–19. http://dx.doi.org/10.4102/abc.v25i1.720.

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Ethnobotanical studies of the Rwenzori Mountain forest area in Bundibugyo District in Uganda were carried out between May and December 1991, and covered the northern part of the Rwenzori Mountain slopes occupied by the Bakonjo people. The presence of a major footpath through the forest with numerous utility trails radiating from it showed that some forest resources are being sought by the local population. Plant biodiversity is high, as is indicated by the fact that in a study plot of only 4 250 m , a total of 115 plant species, 101 genera and 57 families were identified from a collection of 3

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22

Munyeku-Bazitama, Yannick, Francois Edidi-Atani, and Ayato Takada. "Non-Ebola Filoviruses: Potential Threats to Global Health Security." Viruses 16, no. 8 (2024): 1179. http://dx.doi.org/10.3390/v16081179.

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Filoviruses are negative-sense single-stranded RNA viruses often associated with severe and highly lethal hemorrhagic fever in humans and nonhuman primates, with case fatality rates as high as 90%. Of the known filoviruses, Ebola virus (EBOV), the prototype of the genus Orthoebolavirus, has been a major public health concern as it frequently causes outbreaks and was associated with an unprecedented outbreak in several Western African countries in 2013–2016, affecting 28,610 people, 11,308 of whom died. Thereafter, filovirus research mostly focused on EBOV, paying less attention to other equall

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23

Hadijah, Nansamba, Dr Stella Kyohairwe, and Dr Nyenje Aida Lubwama. "Institutionalization of Semi-Formal Local Council Courts and Their Role in Mitigating Gender-Based Violence in Bundibugyo District, Uganda." European Journal of Gender Studies 6, no. 3 (2025): 36–65. https://doi.org/10.47672/ejgs.2609.

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Purpose: The study assessed the impact of institutionalizing semi-formal Local Council Courts (LCCs) on mitigating gender-based violence (GBV) in Bundibugyo District, Uganda. Materials and Methods: Grounded in a positivist paradigm, the study employed a quantitative correlation design. Data were collected from 203 officers involved in GBV mitigation in Bundibugyo District using structured questionnaires. Simple random sampling and census techniques were applied. The study adopted an explanatory linear regression analysis, a parametric test aimed at explaining the effect of the independent vari

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24

Clark, Danielle V., Hannah Kibuuka, Monica Millard, et al. "Long-term sequelae after Ebola virus disease in Bundibugyo, Uganda: a retrospective cohort study." Lancet Infectious Diseases 15, no. 8 (2015): 905–12. http://dx.doi.org/10.1016/s1473-3099(15)70152-0.

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25

Shibar, Arinaitwe, Turyahabwe Deneth, Tugume Azalius, Atuhairwe Godiriva, and Stella Teddy Kanyesigye. "Investigating how Road Development Enhances Agricultural Production in Bubandi Sub County of Bundibugyo District, Uganda." INOSR ARTS AND MANAGEMENT 10, no. 1 (2024): 42–50. http://dx.doi.org/10.59298/inosram/2024/101.4250.

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This study investigated the intertwine between road development and agricultural production in Bubandi Sub County of Bundibugyo District, Uganda. Findings revealed that the poor road network in the district is caused by steep slopes, difficulties in compensating project affected residents, government delays in providing cash, and weather variations. This poor road network equally threatens food security. This is because road development increases the agricultural productive capacity of poor households, lowers input and transportation costs, creates a market for agricultural produce, improved r

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Kozak, Robert, Shihua He, Andrea Kroeker, et al. "Ferrets Infected with Bundibugyo Virus or Ebola Virus Recapitulate Important Aspects of Human Filovirus Disease." Journal of Virology 90, no. 20 (2016): 9209–23. http://dx.doi.org/10.1128/jvi.01033-16.

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ABSTRACTBundibugyo virus (BDBV) is the etiological agent of a severe hemorrhagic fever in humans with a case-fatality rate ranging from 25 to 36%. Despite having been known to the scientific and medical communities for almost 1 decade, there is a dearth of studies on this pathogen due to the lack of a small animal model. Domestic ferrets are commonly used to study other RNA viruses, including members of the orderMononegavirales. To investigate whether ferrets were susceptible to filovirus infections, ferrets were challenged with a clinical isolate of BDBV. Animals became viremic within 4 days

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Versteeg, Krista, Chad Mire, and Thomas Geisbert. "Bundibugyo ebolavirus replicates to lower viral titer in innate immune cells (VIR2P.1171)." Journal of Immunology 194, no. 1_Supplement (2015): 75.10. http://dx.doi.org/10.4049/jimmunol.194.supp.75.10.

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Abstract The current Zaire ebolavirus (ZEBOV) epidemic in West Africa reinforces the need for effective vaccines and therapeutics that protect against all species of ebolavirus (EBOV). To achieve this, we characterized the effect of virus infection of macrophages and dendritic cells using the recently discovered Bundibugyo ebolavirus (BEBOV). BEBOV infection of humans and nonhuman primates has a lower case fatality rate, differing clinical presentations, and longer time to death compared to ZEBOV. More importantly, survivors and non-survivors of BEBOV have detectable antibodies against BEBOV,

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28

Choi, Boseung, Sydney Busch, Dieudonne Kazadi, et al. "Modeling outbreak data: Analysis of a 2012 Ebola virus disease epidemic in DRC." BIOMATH 8, no. 2 (2019): 1910037. http://dx.doi.org/10.11145/j.biomath.2019.10.037.

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We describe two approaches to modeling data from a small to moderate-sized epidemic outbreak. The first approach is based on a branching process approximation and direct analysis of the transmission network, whereas the second one is based on a survival model derived from the classical SIR equations with no explicit transmission information. We compare these approaches using data from a 2012 outbreak of Ebola virus disease caused by Bundibugyo ebolavirus in city of Isiro, Demo- cratic Republic of the Congo. The branching process model allows for a direct comparison of disease transmission acro

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Kankya, Clovice, James Muleme, Lydia Nabawanuka Namakula, George Seruwagi, Christine Mbabazi Mpyangu, and Lesley Rose Ninsiima. "Gender perspectives on zoonotic disease epidemiology; A strength weakness opportunities threats analysis in Bundibugyo district, Uganda." PLOS One 20, no. 5 (2025): e0324442. https://doi.org/10.1371/journal.pone.0324442.

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Background Gender mainstreaming in zoonotic disease prevention and control is paramount to produce sustainable solutions as well as keeping communities at the human-animal-environment interface safe and healthy. It is important to note that zoonoses register high mortality rates globally once they occur and they are highly transmissible. Hence this study aimed to explore the gender perspectives on zoonotic disease epidemiology using a (strength, weakness, opportunities and threats) SWOT analysis in Bundibugyo district, Uganda. Methods This study employed a descriptive participatory approach, u

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Miller, Megan R., Rebekah J. McMinn, Vikram Misra, et al. "Broad and Temperature Independent Replication Potential of Filoviruses on Cells Derived From Old and New World Bat Species." Journal of Infectious Diseases 214, suppl 3 (2016): S297—S302. https://doi.org/10.5281/zenodo.13537329.

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(Uploaded by Plazi for the Bat Literature Project) Filoviruses are strongly associated with several species of bats as their natural reservoirs. In this study, we determined the replication potential of all filovirus species: Marburg marburgvirus, Tai Forest ebolavirus, Reston ebolavirus, Sudan ebolavirus, Zaire ebolavirus, and Bundibugyo ebolavirus. Filovirus replication was supported by all cell lines derived from 6 Old and New World bat species: the hammer-headed fruit bat, Buettikofer's epauletted fruit bat, the Egyptian fruit bat, the Jamaican fruit bat, the Mexican free-tailed bat and th

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Miller, Megan R., Rebekah J. McMinn, Vikram Misra, et al. "Broad and Temperature Independent Replication Potential of Filoviruses on Cells Derived From Old and New World Bat Species." Journal of Infectious Diseases 214, suppl 3 (2016): S297—S302. https://doi.org/10.5281/zenodo.13537329.

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(Uploaded by Plazi for the Bat Literature Project) Filoviruses are strongly associated with several species of bats as their natural reservoirs. In this study, we determined the replication potential of all filovirus species: Marburg marburgvirus, Tai Forest ebolavirus, Reston ebolavirus, Sudan ebolavirus, Zaire ebolavirus, and Bundibugyo ebolavirus. Filovirus replication was supported by all cell lines derived from 6 Old and New World bat species: the hammer-headed fruit bat, Buettikofer's epauletted fruit bat, the Egyptian fruit bat, the Jamaican fruit bat, the Mexican free-tailed bat and th

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Hayman, David T. S. "African Primates: Likely Victims, Not Reservoirs, of Ebolaviruses." Journal of Infectious Diseases 220, no. 10 (2019): 1547–50. https://doi.org/10.5281/zenodo.14819965.

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(Uploaded by Plazi for the Bat Literature Project) (See the Major Article by Ayouba et al, on pages 1599–608)Ebola virus disease (EVD) kills almost half those people infected. Four different viruses from 4 Ebolavirus species have caused EVD in Africa: Zaire ebolavirus (EBOV), Sudan ebolavirus (SUDV), Bundibugyo ebolavirus (BDBV), and Tai Forest ebolavirus (TAFV), with all but TAFV causing fatal human disease. Outbreaks have been sporadic and unpredictable, but the frequency and size of outbreaks appear to be increasing [1, 2]. The ongoing outbreak in the Democratic Republic of the Congo (DRC)

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Lewis, Charles E., Mathieu M. Pinette, Steven M. Lakin, et al. "Experimental Infection of Bundibugyo Virus in Domestic Swine Leads to Viral Shedding with Evidence of Intraspecies Transmission." Transboundary and Emerging Diseases 2024 (January 9, 2024): 1–16. http://dx.doi.org/10.1155/2024/5350769.

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The Ebolavirus genus contains several of the deadliest zoonotic viruses known. One of these, Bundibugyo virus (BDBV), has been the causative agent of two outbreaks of human disease that have resulted in 211 known cases with a case fatality rate of 33.6%. Although bats are routinely implicated as the possible reservoir species for the ebolaviruses, the source of infection for index cases in almost all outbreaks is unknown with only limited epidemiological evidence directly linking human cases to bats. This lack of evidence leaves open the possibility that maintenance of one or more of these vir

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Julius, Batalingaya, and Kyakuwa Aisha. "Child labour and students’ academic performance in selected primary school pupils’ in Nyahuka town council, Bundibugyo district." INOSR ARTS AND HUMANITIES 11, no. 1 (2025): 40–48. https://doi.org/10.59298/inosrah/2025/4048.

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The study titled child labor and students’ school dropouts was conducted in selected primary schools in Nyahuka town council, Bundibugyo district. The research aimed to identify the main causes of school dropouts, examine the correlation between child labor and students’ academic performance, and explore strategies to reduce school dropouts in the area. A descriptive research design was employed, with a sample size of 90 respondents, including teachers, head teachers, and students. Findings revealed that school dropouts were primarily driven by socio-economic challenges, particularly family po

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Holtsberg, Frederick W., Sergey Shulenin, Hong Vu, et al. "Pan-ebolavirus and Pan-filovirus Mouse Monoclonal Antibodies: Protection against Ebola and Sudan Viruses." Journal of Virology 90, no. 1 (2015): 266–78. http://dx.doi.org/10.1128/jvi.02171-15.

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ABSTRACTThe unprecedented 2014-2015 Ebola virus disease (EVD) outbreak in West Africa has highlighted the need for effective therapeutics against filoviruses. Monoclonal antibody (MAb) cocktails have shown great potential as EVD therapeutics; however, the existing protective MAbs are virus species specific. Here we report the development of pan-ebolavirus and pan-filovirus antibodies generated by repeated immunization of mice with filovirus glycoproteins engineered to drive the B cell responses toward conserved epitopes. Multiple pan-ebolavirus antibodies were identified that react to the Ebol

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Bennett, Andrew J., and Tony L. Goldberg. "Pteropine Orthoreovirus in an Angolan Soft-Furred Fruit Bat (Lissonycteris angolensis) in Uganda Dramatically Expands the Global Distribution of an Emerging Bat-Borne Respiratory Virus." Viruses 12, no. 7 (2020): 740. http://dx.doi.org/10.3390/v12070740.

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Pteropine orthoreovirus (PRV; Reoviridae: Spinareovirinae) is an emerging bat-borne zoonotic virus that causes influenza-like illness (ILI). PRV has thus far been found only in Australia and Asia, where diverse old-world fruit bats (Pteropodidae) serve as hosts. In this study, we report the discovery of PRV in Africa, in an Angolan soft-furred fruit bat (Lissonycteris angolensis ruwenzorii) from Bundibugyo District, Uganda. Metagenomic characterization of a rectal swab yielded 10 dsRNA genome segments, revealing this virus to cluster within the known diversity of PRV variants detected in bats

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Shapshak, Paul. "Emergent Risk Group-4 (RG-4) Filoviruses: A paradox in progress." Bioinformation 19, no. 8 (2023): 829. http://dx.doi.org/10.6026/97320630019829.

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Filoviruses, categorized as World Health Organization (WHO) Risk Group 4 (RG-4) pathogens, represent significant global health risks due to their extraordinary virulence. The Filoviridae family encompasses Ebola strains such as Sudan, Zaire, Bundibugyo, Tai Forest (formerly known as Ivory Coast), Reston, and Bombali, in addition to the closely related Marburg and Ravn virus strains. Filoviruses originated from a common ancestor about 10,000 years ago and displayed remarkable consistency in genetic heterogeneity until the 20th century. However, they overcame a genetic bottleneck by mid-century.

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Bwambale Bisereko, Blasio, Godfrey Sseremba, and Julius Mwine. "Disease prevalence and shade tree diversity in smallholder cocoa (Theobroma cacao) farms: case of Bundibugyo District, Western Uganda." International Journal of Scientific Research and Management 9, no. 02 (2021): 330–44. http://dx.doi.org/10.18535/ijsrm/v9i02.ah01.

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Cocoa (Theobroma cacao) growing systems in Uganda consists of shade systems with different tree species. Tree shade systems are the pure stand trees in the cocoa plantation which have been attributed towards reducing on pests and disease incidences, shade provision, boosting fertility, Agro biodiversity, fodder and improving production. The study was aimed at identifying potential shade tree species that can minimize disease threats on cocoa farms. Eighty-two cocoa farmers were reached out of 120 cocoa farmers in Bundibugyo that possessed at least five acres of the plantation in a purposive sa

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Rahim, Md, Min Wang, Tong Wang, et al. "Generation and Characterization of Anti-Filovirus Nucleoprotein Monoclonal Antibodies." Viruses 11, no. 3 (2019): 259. http://dx.doi.org/10.3390/v11030259.

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Filoviruses cause lethal hemorrhagic fever in humans. The filovirus nucleoprotein (NP) is expressed in high abundance in infected cells and is essential for virus replication. To generate anti-filovirus monoclonal antibodies (mAbs) against the NP, mice were immunized with peptides known as B-cell epitopes corresponding to different filovirus NPs, and hybridomas were screened using FLAG-tagged filovirus NP constructs. Numerous mAbs were identified, isotyped, and characterized. The anti-NP mAbs demonstrated different ranges of binding affinities to various filovirus NPs. Most of the clones speci

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Koshlan, Tatiana V., and Kirill G. Kulikov. "Identifying Viral Protein Interactions’ Order During Replication and Transcription Processes." Biophysica 5, no. 2 (2025): 11. https://doi.org/10.3390/biophysica5020011.

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This study focuses on biochemical pathways of complex biochemical formation, taking into account various thermodynamic parameters that change as the complexity and molecular weight of complex molecules increase. We conducted a study of the co-direction of changes in thermodynamic quantities such as lg[Kd], TΔS, Δ(ΔW), and lg(cond(W)) during the transition from a monomer to a dimer and then to a trimer and tetramer. In this work, we assume that the co-direction of changes in thermodynamic quantities as the final molecular formation being achieved signals a higher affinity of molecules among the

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Falzarano, Darryl, Friederike Feldmann, Allen Grolla, et al. "Single Immunization With a Monovalent Vesicular Stomatitis Virus–Based Vaccine Protects Nonhuman Primates Against Heterologous Challenge With Bundibugyo ebolavirus." Journal of Infectious Diseases 204, suppl_3 (2011): S1082—S1089. http://dx.doi.org/10.1093/infdis/jir350.

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Shchelkanov, M. Yu, N. Magassouba, V. G. Dedkov, et al. "NATURAL RESERVOIR OF FILOVIRUSES AND TYPES OF ASSOCIATED EPIDEMIC OUTBREAKS IN AFRICA." Annals of the Russian academy of medical sciences 72, no. 2 (2017): 112–19. http://dx.doi.org/10.15690/vramn803.

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Family Filoviridae includes a set of etiological agents of human hemorrhagic fevers distributed in Africa: Zaire ebolavirus (ZEBOV), Sudan ebolavirus (SUDV), Bundibugyo ebolavirus (BDBV), Taï Forest ebolavirus (TAFV), Marburg marburgvirus (MMARV). Historiography and recent taxonomical structure of Filoviridae family are considered in the review. The discussed data of laboratory and ecological-virological field researches demonstrate the presence of a natural reservoir of filoviruses among fruit-bats (Chiroptera, Megachiroptera) which carry filovirus infection without clinical signs but allocat

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Tensaba Andes Akafa and Dr. Kingsley Iyoko Iseko. "Dinga Dinga Disease Uncovered: A Call to Act Fast Against Uganda's Puzzling Health Crisis." International Journal of Emerging Multidisciplinaries: Biomedical and Clinical Research 3, no. 1 (2025): 6. https://doi.org/10.54938/ijemdbmcr.2025.03.1.391.

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In early 2023, Uganda reported a novel illness known as "Dinga Dinga Disease" (DDD), characterized mainly by uncontrollable body tremors, primarily affecting women and girls in the Bundibugyo district. This exploratory article examines the disease's symptoms, epidemiology, and potential causes, drawing parallels to the historical "Dancing Plague" of 1518. DDD presents with excessive shaking, high fever, extreme weakness, and feelings of paralysis, severely impacting mobility and daily activities, yet it remains self-limiting with no reported fatalities. The article highlights the urgent need f

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Barrette, Roger W., Lizhe Xu, Jessica M. Rowland, and Michael T. McIntosh. "Current perspectives on the phylogeny of Filoviridae." Infection, Genetics and Evolution 11, no. 7 (2011): 1514–19. https://doi.org/10.5281/zenodo.13472330.

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(Uploaded by Plazi for the Bat Literature Project) Sporadic fatal outbreaks of disease in humans and non-human primates caused by Ebola or Marburg viruses have driven research into the characterization of these viruses with the hopes of identifying host tropisms and potential reservoirs. Such an understanding of the relatedness of newly discovered filoviruses may help to predict risk factors for outbreaks of hemorrhagic disease in humans and/or non-human primates. Recent discoveries such as three distinct genotypes of Reston ebolavirus, unexpectedly discovered in domestic swine in the Philippi

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Bower, Hilary, and Judith R. Glynn. "A systematic review and meta-analysis of seroprevalence surveys of ebolavirus infection." Scientific Data 4, no. 1 (2017): 160133. https://doi.org/10.5281/zenodo.13538118.

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(Uploaded by Plazi for the Bat Literature Project) Asymptomatic ebolavirus infection could greatly influence transmission dynamics, but there is little consensus on how frequently it occurs or even if it exists. This paper summarises the available evidence on seroprevalence of Ebola, Sudan and Bundibugyo virus IgG in people without known ebolavirus disease. Through systematic review, we identified 51 studies with seroprevalence results in sera collected from 1961 to 2016. We tabulated findings by study population, contact, assay, antigen and positivity threshold used, and present seroprevalenc

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Barrette, Roger W., Lizhe Xu, Jessica M. Rowland, and Michael T. McIntosh. "Current perspectives on the phylogeny of Filoviridae." Infection, Genetics and Evolution 11, no. 7 (2011): 1514–19. https://doi.org/10.5281/zenodo.13472330.

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Abstract:

(Uploaded by Plazi for the Bat Literature Project) Sporadic fatal outbreaks of disease in humans and non-human primates caused by Ebola or Marburg viruses have driven research into the characterization of these viruses with the hopes of identifying host tropisms and potential reservoirs. Such an understanding of the relatedness of newly discovered filoviruses may help to predict risk factors for outbreaks of hemorrhagic disease in humans and/or non-human primates. Recent discoveries such as three distinct genotypes of Reston ebolavirus, unexpectedly discovered in domestic swine in the Philippi

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47

Bower, Hilary, and Judith R. Glynn. "A systematic review and meta-analysis of seroprevalence surveys of ebolavirus infection." Scientific Data 4, no. 1 (2017): 160133. https://doi.org/10.5281/zenodo.13538118.

Full text

Abstract:

(Uploaded by Plazi for the Bat Literature Project) Asymptomatic ebolavirus infection could greatly influence transmission dynamics, but there is little consensus on how frequently it occurs or even if it exists. This paper summarises the available evidence on seroprevalence of Ebola, Sudan and Bundibugyo virus IgG in people without known ebolavirus disease. Through systematic review, we identified 51 studies with seroprevalence results in sera collected from 1961 to 2016. We tabulated findings by study population, contact, assay, antigen and positivity threshold used, and present seroprevalenc

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48

Barrette, Roger W., Lizhe Xu, Jessica M. Rowland, and Michael T. McIntosh. "Current perspectives on the phylogeny of Filoviridae." Infection, Genetics and Evolution 11, no. 7 (2011): 1514–19. https://doi.org/10.5281/zenodo.13472330.

Full text

Abstract:

(Uploaded by Plazi for the Bat Literature Project) Sporadic fatal outbreaks of disease in humans and non-human primates caused by Ebola or Marburg viruses have driven research into the characterization of these viruses with the hopes of identifying host tropisms and potential reservoirs. Such an understanding of the relatedness of newly discovered filoviruses may help to predict risk factors for outbreaks of hemorrhagic disease in humans and/or non-human primates. Recent discoveries such as three distinct genotypes of Reston ebolavirus, unexpectedly discovered in domestic swine in the Philippi

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49

Barrette, Roger W., Lizhe Xu, Jessica M. Rowland, and Michael T. McIntosh. "Current perspectives on the phylogeny of Filoviridae." Infection, Genetics and Evolution 11, no. 7 (2011): 1514–19. https://doi.org/10.5281/zenodo.13472330.

Full text

Abstract:

(Uploaded by Plazi for the Bat Literature Project) Sporadic fatal outbreaks of disease in humans and non-human primates caused by Ebola or Marburg viruses have driven research into the characterization of these viruses with the hopes of identifying host tropisms and potential reservoirs. Such an understanding of the relatedness of newly discovered filoviruses may help to predict risk factors for outbreaks of hemorrhagic disease in humans and/or non-human primates. Recent discoveries such as three distinct genotypes of Reston ebolavirus, unexpectedly discovered in domestic swine in the Philippi

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Namubiru, Aisha, Maliko Kisembo, Tawheed Kasiita, Edmond Kagambe, and Tawfik Kasiita. "Perceptions of Teachers on the Implementation of the Competence-Based Curriculum in Secondary Schools in Bundibugyo and Ntoroko Districts, Uganda." East African Journal of Education Studies 7, no. 3 (2024): 13–27. http://dx.doi.org/10.37284/eajes.7.3.2013.

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The Competence-Based Curriculum (CBC), introduced to enhance learners' skills and competencies, has undergone nationwide adoption, prompting the need to assess its effectiveness at the grassroots level. This study delves into the perceptions of teachers regarding CBC implementation in secondary schools within the Bundibugyo and Ntoroko Districts. Employing a mixed methods approach through descriptive survey research, data was collected via interviews, group discussions, and questionnaires. The study's sample size comprised 397 participants, including 365 teachers selected via simple random sam

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