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Journal articles on the topic 'Bureau of historical research'

Author: Grafiati

Published: 4 June 2021

Last updated: 28 July 2025

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1

Melnyk, Rostyslav. "Student Design and Engineering Bureau of Lviv Polytechnic Institute in the 1960s – 70s: Directions and Forms of Activities." Scientific Papers of the Vinnytsia Mykhailo Kotsyiubynskyi State Pedagogical University. Series: History, no. 38 (December 2021): 56–61. http://dx.doi.org/10.31652/2411-2143-2021-38-56-61.

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The purpose of the article is to highlight the main directions and forms of research activities of the Student Design and Engineering Bureau of Lviv Polytechnic Institute in the 1960s – 70s. In particular the author considers and characterizes the types of research performed by employees of the bureau, as well as the ways and methods of performing these works by students. The methodological basis of the study are general scientific (analysis, synthesis, generalization) and special-historical (historical-genetic, historical-comparative, historical-typological) methods, as well as the principles

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Paschka, Peter, Hervé Dombret, Xavier Thomas, et al. "Ivosidenib Improves Overall Survival Relative to Standard Therapies in Relapsed or Refractory Mutant IDH1 AML: Results from Matched Comparisons to Historical Controls." Blood 136, Supplement 1 (2020): 18–19. http://dx.doi.org/10.1182/blood-2020-136957.

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Background: A European Marketing Authorization Application for ivosidenib (IVO) is currently under review for the indication of mutant isocitrate dehydrogenase 1 (mIDH1) R132 relapsed/refractory (R/R) acute myeloid leukemia (AML) in adult patients (pts) who have received ≥ 2 prior regimens, including ≥ 1 standard intensive chemotherapy (IC) regimen, or are not candidates for IC and have received ≥ 1 prior non-intensive regimen. IVO is an oral, potent, targeted inhibitor of mIDH1 and was approved by the FDA for the treatment of mIDH1 R/R AML in 2018, and in newly diagnosed AML in adults ≥ 75 ye

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3

Guo, Yanan, Qiong Tong, Zhengjiao Li, and Yuhao Zhao. "Research on Carbon Emission Quota of Railway in China from the Perspective of Equity and Efficiency." Sustainability 14, no. 21 (2022): 13789. http://dx.doi.org/10.3390/su142113789.

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Under the constraint of total carbon emissions, the allocation of carbon emission quotas of 18 railway bureaus in China is conducted to the realization of carbon emission reduction targets of China’s railway transportation industry. This paper proposes a carbon emission quota model for China’s railway industry from the perspective of equity and efficiency and innovatively undertakes research on the allocation of carbon emission quotas for railway administrations. This paper constructs an econometric model to analyze the impact of various influencing factors on China’s railway operation carbon

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4

Ruggles, Steven. "Comparability of the Public Use Files of the U.S. Census of Population, 1880–1980." Social Science History 15, no. 1 (1991): 123–58. http://dx.doi.org/10.1017/s0145553200021039.

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Most of the information released by the Census Bureau has always consisted of summary population counts cross-tabulated by individual or family characteristics. Although these data form the basic description of the American population, they are not ideal for analytical research. The Census Bureau cannot anticipate all the needs of social scientists, so many topics are inadequately covered in the published census volumes. For historical research, the problem is especially acute, because the published data are fairly sketchy for the period before 1940. Moreover, the classifications employed by t

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Ko, Bor-Sheng, Su-Peng Yeh, Hsiao-Wen Kao, Yuan-Bin Yu, Shyh-Tyan Ou, and Cheng-Shyong Chang. "A Case-Control Study to Compare the Survival Benefits of Patients Who Suffer from Peripheral T-Cell Lymphoma (PTCL) Treated with Chidamide, a Histone Deacetylase Inhibitor, in China with a Historical Matched Cohort of Patients Treated with Conventional Therapy in Taiwan: Survival Advantage Is Demonstrated." Blood 132, Supplement 1 (2018): 5367. http://dx.doi.org/10.1182/blood-2018-99-114738.

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Abstract Background Chidamide is a histone acetylase (HDAC) inhibitor with significant and specific inhibitory activities against HDAC subtypes 1, 2, 3, and 10. Although it is already approved for treating peripheral T-cell lymphoma (PTCL) with a phase II clinical trial in several countries, the evidences comparing its efficacy with conventional chemotherapy in PTCL is still very limited. This retrospective observational study compared the survival benefits of 65 patients with relapsed or refractory PTCL treated on a phase II pivotal clinical trial (CHIPEL) of Chidamide in China with 65 matche

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Silalahi, Clara Monika, and Katerina Bataha. "Manajemen Pengarsipan pada Biro Umum Sekretariat Daerah Provinsi Jawa Timur." Business Perspective Journal 4, no. 1 (2024): 1–10. http://dx.doi.org/10.37090/bpj.v4i1.1357.

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Archives serve as a repository of invaluable information crucial to the organizational sustainability process, capturing diverse historical aspects. The primary objective of archive management is to systematically organize, store, and facilitate access to this information, catering to researchers, historians, scholars, and individuals interested in the study of specific subjects or periods. This research adopts a qualitative descriptive methodology, utilizing observations, documentation, and interviews for data collection. The collected data is then systematically organized and expounded upon

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Ling, Ling, and Xinhua Li. "Analysis of Discrepancies Between Destination Image and Tourists' Perceived Image: Taking Fuzhou as a Case." Communications in Humanities Research 23, no. 1 (2023): 14–22. http://dx.doi.org/10.54254/2753-7064/23/20230072.

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Taking Fuzhou as a case study, this research analyzes tourist network travel notes, online comments, and official website reports of the tourism bureau, and uses the word frequency statistical function of semantic analysis software to extract high-frequency words of tourist perception and official website projection of tourism image, and constructs social relations and semantic networks to compare and analyze tourist perception and official website dissemination of tourism image. The research results show that the Fuzhou tourism image perceived by tourists can be summarized into four dimension

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Unglaub, Julia M., Richard F. Schlenk, Maher Hanoun, et al. "Venetoclax-Azacitidine As Salvage Therapy and Bridge to Allogeneic Cell Transplantation in Relapsed/Refractory AML Compared to Historical Data of the SAL Registry Study." Blood 138, Supplement 1 (2021): 4418. http://dx.doi.org/10.1182/blood-2021-151287.

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Abstract Background Venetoclax (VEN)-based combination therapy with hypomethylating agents (HMA) has been approved for first-line treatment in patients ineligible for intensive treatment based on two randomized trials. There is some evidence for efficacy also in the in relapsed/ refractory setting (R/R), but comparative controlled data is lacking. Here, we report our experience of VEN-Azacitidine (AZA) in R/R AML salvage treatment and bridge to allogeneic cell transplantation (allo-HCT) in fit patients compared to historical data from the Study Alliance Leukemia (SAL) registry (ClinicalTrials.

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Bergua Burgues, Juan Miguel M., Isabel Cano-Ferri, David Martínez-Cuadron, et al. "Outcomes after Plerixafor Plus FLAG-IDA (PLERIFLAG) Versus FLAG-IDA +/- Gentuzumab for Adult Patients with First Relapsed/Refractory AML: A Propensity Score Analysis from the Pethema Registry." Blood 134, Supplement_1 (2019): 1321. http://dx.doi.org/10.1182/blood-2019-128568.

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BACKGROUND AND OBJECTIVES: Chemosensitization using plerixafor combined with FLAG-IDA (PLERIFLAG regimen) showed promising results (48% CR/CRi) in a phase 2 trial for primary refractory and early relapsed (duration of first CR &lt;12 months) Adult AML patients. We aim to compare retrospectively results of the PLERIFLAG cohort versus historical cohorts of patients salvaged with FLAG-IDA (Fludarabine, Idarubicine, Cytarabine, G-CSF as priming agent), or FLAGO-IDA (Gemtuzumab plus FLAG-IDA) registered in the PETHEMA epidemiologic AML registry (NCT02006004). To match different cohorts, we used

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Lai, Manhong, and Lijia Wang. "Fulfilling Set Objectives: A Case Study of Teacher Development in Two Primary Schools in Beijing." ECNU Review of Education 2, no. 2 (2019): 178–95. http://dx.doi.org/10.1177/2096531119853083.

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Purpose: This study aims to reveal the recent characteristics of school-based teacher development (STD) in China since it is perceived as a key measure to achieve success in raising educational quality in the country. Design/Approach/Methods: A qualitative research approach with in-depth interviews of 18 teachers at two primary schools in Beijing was used. Findings: Through the lens of cultural-historical activity theory (CHAT), it was observed that the objectives adaptation of teacher communities was made under the control of the District Education Bureau. STD provides the venue for ordinary

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Szczepanowski, Monika, Johanna Richter, Miriam Kelm, et al. "Expression of CD20 Affects Early MRD Response to Rituximab in Adult B Cell Precursor Lymphoblastic Leukemia of the GMALL 08/2013 Trial." Blood 138, Supplement 1 (2021): 2301. http://dx.doi.org/10.1182/blood-2021-150375.

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Abstract Introduction Rituximab (R) administration results in significant outcome improvement in B cell precursor acute lymphoblastic leukemia (B-ALL) patients (pts), but is usually restricted to pts with ≥20% CD20+ leukemic blasts. Yet, this arbitrary cut-off is not proven biologically sensible. Moreover, CD20 expression might differ between blood (pb) and bone marrow (bm) and varies under prednisone during early treatment. In the present GMALL08/2013 trial R is administered to all BCR-ABL1-negative B-ALL pts irrespective of the initial leukemic CD20 expression. We assessed the initial and po

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Levy, Howard, Levani Makhaldiani, Genadi Iosava, et al. "Phase 2/3 Trial of Subcutaneously Administered Marzeptacog Alfa (activated) an Engineered FVIIa in Hemophilia with Inhibitors - Pharmacokinetics, Pharmacodynamics, Safety and Efficacy." Blood 132, Supplement 1 (2018): 1198. http://dx.doi.org/10.1182/blood-2018-99-112567.

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Abstract Background: In hemophilia patients with inhibitors, hemostasis can be achieved using bypass agents: activated plasma-derived prothrombin complex concentrates (aPCC), recombinant Factor VIIa (FVIIa), or emicizumab - that can only manage hemophilia A. Marzeptacog alfa (activated) (MarzAA), an engineered recombinant FVIIa with enhanced biological properties enabling subcutaneous (SQ) delivery was developed using a rational protein design approach. It has 7-fold increased catalytic activity and prolonged duration of effect demonstrated in a single-dose intravenous (IV) study that document

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Eron, Joseph J., Aimee Wilkin, Moti Ramgopal, et al. "1002. A Daily Single Tablet Regimen (STR) of Bictegravir/Emtricitabine/Tenofovir Alafenamide (B/F/TAF) in Virologically-Suppressed Adults Living with HIV and End Stage Renal Disease on Chronic Hemodialysis." Open Forum Infectious Diseases 7, Supplement_1 (2020): S529—S530. http://dx.doi.org/10.1093/ofid/ofaa439.1188.

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Abstract Background Treatment for people living with HIV (PLWH) and end stage renal disease (ESRD) on hemodialysis (HD) has previously required complex dose-adjusted regimens. We evaluated a daily regimen of elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide (E/C/F/TAF) and established this treatment as effective and safe, showing that daily TAF resulted in lower plasma tenofovir exposure than a historical comparison of once weekly tenofovir disoproxil fumarate in patients with ESRD on HD. After week (W) 96, participants transitioned to daily B/F/TAF to assess whether efficacy and saf

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Ruban, M., and V. Ponomarenko. "The development and construction of narrow-gauge locomotives at the Dnipropetrovsk electric locomotive plant (1969–1991)." Studies in history and philosophy of science and technology 29, no. 2 (2021): 100–110. http://dx.doi.org/10.15421/272026.

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The article attempts to investigate the historical circumstances of the development and serial construction of narrow-gauge electric locomotives at the Dnepropetrovsk Electric Locomotive Plant based on a comprehensive analysis of sources and scientific literature. It is determined that during the 1960s and 1990s the staff of the Special Design and Technology Bureau of the Dnipropetrovsk Plant, having a strong research and production potential, developed and created projects of unique narrow-gauge electric locomotives of PEU 1 series (IELNG1 – industrial narrow-gauge electric locomotive type 1)

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15

Slieker, François, and Niels Raes. "Database of butterfly and moth observations in the Netherlands: research from 1947-2020." Biodiversity Data Journal 10 (April 7, 2022): e78784. https://doi.org/10.3897/BDJ.10.e78784.

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The Natural History Museum Rotterdam (NMR) is a regional natural history museum in The Netherlands that focuses on nature and biodiversity of the city of Rotterdam and its surroundings. Bureau Stadsnatuur Rotterdam (bSR) is part of the NMR and collects, mainly on behalf of third parties, data on the flora and fauna from primarily urban areas. The NMR has received a large amount of observation data (1,363 different species in 886,902 observations), in particular of moths and mainly from the Provinces of Zuid-Holland, Noord-Holland and Noord-Brabant from the period 1947-2020. The observation dat

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Fluss, Sev S. "The Evolution of Research Ethics: The Current International Configuration." Journal of Law, Medicine & Ethics 32, no. 4 (2004): 596–603. http://dx.doi.org/10.1111/j.1748-720x.2004.tb01965.x.

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I propose in this essay to briefly describe some of the main current stakeholders who issue guidance on the ethics of human subjects research. This will be preceded by a very brief historical introduction.Prior to World War II, as far as I have been able to ascertain, there were no international efforts to regulate human experimentation. National activities were few and far between. One exception was a Directive on Human Experimentation issued in December 1900 by the then Prussian Minister of Religious, Educational and Medical Mairs. This was followed by a Circular on innovative therapy and sc

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Amurskaya, M. A. "Accounting and Statistics in China Under the Qing Dynasty." Accounting. Analysis. Auditing 9, no. 6 (2023): 61–70. http://dx.doi.org/10.26794/2408-9303-2022-9-6-61-70.

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The Chinese economy has been steadily showing growth and development for decades, which attracts the attention of the largest scientists around the world to the economic model of this country, business practices, accounting and statistics. The author conducted this study using the historical observation methods, comparison, sampling, systematization and generalization. Also, the author studied sources mainly in Chinese and analyzed publicly available publications in Russian and English. The research divided the features of the national economy growth during the Qing Dynasty into two historical

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Knepper, Todd C., Yehuda E. Deutsch, Chirag K. Bhagat, et al. "Increased Frequency of IDH1/2 Mutations in Extramedullary Acute Myeloid Leukemia." Blood 132, Supplement 1 (2018): 1524. http://dx.doi.org/10.1182/blood-2018-99-113088.

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Abstract Introduction The identification of somatic genomic alterations in cancer has brought forth a paradigm change in the personalized management of patients with acute myeloid leukemia (AML). This is exemplified by the recent FDA approvals with the targeted small molecule inhibitors of mutant IDH1 (ivosidenib) and IDH2 (enasidenib) for patients with relapsed/refractory AML. IDH1/2 mutations have been reported to occur in approximately 16-20% of patients with AML based on the largest published cohorts to date (Dinardo et al., Am J Hematol, 2015; Papaemmanuil et al., NEJM, 2016). However, th

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Armand, Philippe, John Kuruvilla, Alex F. Herrera, et al. "Characterizing Safety in Patients with Hematologic Malignancies Receiving Allogeneic Stem Cell Transplant (Allo-SCT) Following Pembrolizumab Therapy." Blood 138, Supplement 1 (2021): 3924. http://dx.doi.org/10.1182/blood-2021-148528.

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Abstract Introduction: Allogeneic stem cell transplant (allo-SCT) and checkpoint blockade both have efficacy in some lymphoid malignancies. However, the safety of allo-SCT after programmed cell death 1 (PD-1) blockade in these patients (pts) remains a question of high clinical interest. We present data from an analysis from 4 KEYNOTE phase 1-3 studies to assess the incidence and severity of complications in pts who received allo-SCT following pembrolizumab therapy. Methods: The analysis included pts with a known transplant date who received an allo-SCT within 2 years of the last dose of study

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Straus, David J., Monika Dlugosz-Danecka, Joseph M. Connors, et al. "Brentuximab Vedotin with Chemotherapy for Patients with Previously Untreated, Stage III/IV Classical Hodgkin Lymphoma: 5-Year Update of the ECHELON-1 Study." Blood 136, Supplement 1 (2020): 26–28. http://dx.doi.org/10.1182/blood-2020-137089.

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Introduction Historically, nearly all relapses in classical Hodgkin lymphoma (cHL) occur within the first 5 years (Radford et al, BMJ 1997). In the phase 3 ECHELON-1 study (NCT01712490), treatment with brentuximab vedotin, doxorubicin, vinblastine, and dacarbazine (A+AVD) significantly improved modified progression-free survival (PFS) in patients (pts) with newly-diagnosed Stage III/IV cHL compared with doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) (Connors et al, NEJM 2018). 3- and 4-year follow-up (Straus et al, Blood 2020; Bartlett et al, Blood 2019) reported durable PFS benef

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Mares, Dennis M., and Kenneth W. Moffett. "Climate Change and Crime Revisited: An Exploration of Monthly Temperature Anomalies and UCR Crime Data." Environment and Behavior 51, no. 5 (2019): 502–29. http://dx.doi.org/10.1177/0013916518781197.

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A growing body of research suggests a positive connection between climate change and crime, but few studies have explored the seasonal nature of that link. Here, we examine how the impact of climate change on crime may partly depend on specific times of the year as recent climatological research suggests that climate change may have a diverging impact during different times of the year. To do so, we utilize the largest, most current dataset of all main categories of reported crime by month and year in the United States—the Federal Bureau of Investigation’s (FBI) Uniform Crime Reports. We emplo

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Bastos-Oreiro, Mariana, Antonio Gutierrez, Juan Luis Reguera, et al. "Rreal-World Results from Anti-CD19 CAR-T Cell Therapy for Relapsed or Refractory Diffuse Large B-Cell Lymphoma in Spain and Comparison with Previous Standard of Care: A Geltamo/Geth Study." Blood 138, Supplement 1 (2021): 3850. http://dx.doi.org/10.1182/blood-2021-147670.

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Abstract Introduction. The prognosis of patients with relapsed or refractory (R/R) diffuse large B-cell lymphoma (DLBCL) is poor. Chimeric antigen receptor (CAR) T-cell therapy is approved for R/R DLBCL (≥3 rd line) in Spain since April 2019, based on data from single-arm phase 2 trials that showed complete response (CR) rates between 40-50% and prolonged remissions in 30-40% of patients. Real-world (RW) data from different countries have shown similar efficacy to pivotal trials, but there are no studies focused on the global Spanish experience, including different constructs with a large numb

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N. Maligro, John Reinhard. "A Five-Year Fire Incidents Data Analysis in the City of Ozamiz." Middle East Journal of Applied Science & Technology 05, no. 02 (2022): 99–110. http://dx.doi.org/10.46431/mejast.2022.5212.

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Fire incidents in any cause may lead to a devastating effect to the community or family where the fire incident happens. It is considered as an accident that could destroy properties of the family in a very short period of time. This study determined the five-year trend analysis of fire incidents in Ozamiz City using the available historical data from 2016-2021. The study employed retrospective method of research. Since it is a retrospective study, the result of interest has already occurred, and the data obtained is from records, no volunteers will be used in this study. However, the Bureau o

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Nogami, Keiji, Masashi Taki, Tadashi Matsushita, et al. "Outcome of the Japanese Immune Tolerance Induction (ITI) Registry and Predictors of Successful ITI." Blood 126, no. 23 (2015): 3526. http://dx.doi.org/10.1182/blood.v126.23.3526.3526.

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Abstract [Background] Immune tolerance induction (ITI) therapy is the only therapeutic approach that can eradicate factor (F)VIII and FIX inhibitors in patients with hemophilia A (HA) and B (HB), respectively. Although results of several retrospective cohort studies have been published, predictors of successful outcome are still debated. Nonetheless, little information is so far available in terms of large ITI cohort in non-Caucasian countries. [Aim] In this study, we performed a retrospective cohort study on ITI therapy carried out for Japanese hemophilia patients with inhibitors to understan

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Nowakowski, Grzegorz S., Lori A. Leslie, Erel Joffe, et al. "A Multi-Center, Dose-Finding Study to Assess Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of a Novel IRAK4 Inhibitor CA-4948 in Combination with Ibrutinib, in Patients with Relapsed or Refractory Hematologic Malignancies." Blood 136, Supplement 1 (2020): 49–50. http://dx.doi.org/10.1182/blood-2020-140884.

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Introduction: Interleukin-1 receptor-associated kinase 4 (IRAK4) is essential for toll-like receptor (TLR) and interleukin-1 receptor (IL-1R) signaling in immune cells including B lymphocytes. It forms the Myddosome complex with the MYD88 adaptor protein, with IRAK4 being essential for downstream signaling, maximal activation of NFkB with inflammatory and immune response and tumor promotion [Treon 2012; Rhyasen 2015]. CA-4948 is a novel small molecule, oral inhibitor of IRAK4, first-in-class and only suppressor of the TLR pathway currently tested in hematological malignancies. When combined wi

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Cespedes, Michelle, Jill Blumenthal, Karam Mounzer, et al. "848. Approaches to Optimize Recruitment of Historically Underrepresented Black and Hispanic/LatinX MSM, Transgender, and Gender Non-binary Individuals into the Lenacapavir for PrEP (PURPOSE 2) Trial." Open Forum Infectious Diseases 8, Supplement_1 (2021): S514. http://dx.doi.org/10.1093/ofid/ofab466.1043.

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Abstract Background Black and Hispanic/Latinx gay and other men who have sex with men (MSM), transgender women (TGW), transgender men (TGM), and gender nonbinary individuals (GNB) have been historically underrepresented in HIV prevention trials despite being disproportionately affected by the disease. Therefore, studies of pre-exposure prophylaxis (PrEP), a highly effective intervention for reducing HIV incidence, should include these individuals, and doing so would promote generalizability of the findings. Methods PURPOSE 2 (GS-US-528-9023) will evaluate a twice-yearly long-acting subcutaneou

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Bailey, Neil, Tenzin Tsomo, Jennie Szeto, et al. "Acalabrutinib Plus RICE Followed By Autologous Hematopoietic Cell Transplantation and/or Acalabrutinib Maintenance Therapy for Patients with Relapsed/Refractory Diffuse Large B-Cell Lymphoma." Blood 136, Supplement 1 (2020): 34. http://dx.doi.org/10.1182/blood-2020-141074.

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Background: Patients with relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL) often have a poor prognosis despite therapies using second-line chemoimmunotherapy. Achievement of CR with second-line therapy is associated with improved long-term outcomes. Unfortunately, only 25-35% of patients achieve complete response (CR) with RICE chemotherapy alone. The addition of novel targeted agents such as Bruton Tyrosine Kinase inhibitors (BTKi) to second-line therapy may offer improved treatment responses given the importance of B-cell receptor (BCR) signaling in DLBCL. BTK has been shown t

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Levin, Yaroslav. "FBI Opposition to German and Japanese Nationalist Organizations in the United States (1941–1945)." Novaia i noveishaia istoriia, no. 6 (2023): 109. http://dx.doi.org/10.31857/s013038640024078-3.

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In modern research on the history of the United States in World War II, it is quite popular to study the opposition of the American special services and, in particular, the Federal Bureau of Investigation (FBI) to various organizations of the German and Japanese diasporas in new historical conditions. The appeal to traditional methods of historical research, comparative studies and the principles of historicism will make it possible to more accurately trace the process of tightening the counterintelligence work of the Bureau and the close connection of concerns about the involvement of public

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Park, Nari, Yeong Hyeon Gu, and Seong Joon Yoo. "Synthesizing Individual Consumers′ Credit Historical Data Using Generative Adversarial Networks." Applied Sciences 11, no. 3 (2021): 1126. http://dx.doi.org/10.3390/app11031126.

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The financial sector accumulates a massive amount of consumer data that contain the most sensitive information daily. These data are strictly limited outside the financial institutions, sometimes even within the same organization, for various reasons such as privacy laws or asset management policy. Financial data has never been more valuable, especially when assessed jointly with data from different industries, including healthcare, insurance, credit bureau, and research institutions. Therefore, it is critical to generate synthetic datasets that retain the statistical or latent properties of t

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Ningsih, Widya Fitria. "The Forgotten Medium: Hoso Kanri Kyoku and the Beginning of National Broadcasting in Indonesia." Lembaran Sejarah 12, no. 1 (2017): 36. http://dx.doi.org/10.22146/lembaran-sejarah.25518.

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This essay examines Hoso Kanri Kyoku, a bureau of radio centre and regulation, which has been much underestimated and understudied. It became an instrument of mass mobilization and mass psychology in the Japanese occupation period. The essay sees also the pivotal role of this institution in disseminating ideas of ‘ke-Indonesiaan’. The aim of this essay is to show how the transformation process of the institution after the proclamation of Indonesian independence. The essay uses historical archival research as a method of data collection. This essay have indirectly presented that the Soeharto re

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Berge, Travis J., and Óscar Jordá. "Evaluating the Classification of Economic Activity into Recessions and Expansions." American Economic Journal: Macroeconomics 3, no. 2 (2011): 246–77. http://dx.doi.org/10.1257/mac.3.2.246.

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The Business Cycle Dating Committee of the National Bureau of Economic Research provides a historical chronology of business cycle turning points. We investigate three central aspects of this chronology. How skillful is the Dating Committee when classifying economic activity into expansions and recessions? Which indices of economic conditions best capture the current but unobservable state of the business cycle? And which indicators best predict future turning points, and at what horizons? We answer each of these questions in detail using methods specifically designed to assess classification

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Goldberg, Aaron D., Robert H. Collins, Richard M. Stone, et al. "Addition of Crenolanib to Induction Chemotherapy Overcomes the Poor Prognostic Impact of Co- Occurring Driver Mutations in Patients with Newly Diagnosed FLT3-Mutated AML." Blood 132, Supplement 1 (2018): 1436. http://dx.doi.org/10.1182/blood-2018-99-117016.

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Abstract Background: Patients with AML harboring FLT3 mutations have poor clinical outcomes. Furthermore, FLT3 mutations frequently co-occur with other driver mutations, such as NPM1 with DNMT3A, WT1, and RUNX1, that are associated with poor prognosis. Crenolanib is a highly potent and specific type-I FLT3 inhibitor, which has shown promising safety and efficacy in combination with chemotherapy. Here we report the outcomes of newly diagnosed FLT3 mutated AML patients treated with crenolanib and intensive 7 + 3 based chemotherapy (NCT02283177) by baseline genomic profile. Methods: Patients were

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Fathi, Amir T., Harry P. Erba, Jeffrey E. Lancet, et al. "Vadastuximab Talirine Plus Hypomethylating Agents: A Well-Tolerated Regimen with High Remission Rate in Frontline Older Patients with Acute Myeloid Leukemia (AML)." Blood 128, no. 22 (2016): 591. http://dx.doi.org/10.1182/blood.v128.22.591.591.

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Abstract Background Treatment of AML among the elderly is challenging due to intolerance of intensive therapy and greater prevalence of therapy-resistant biology. Hypomethylating agents (HMAs) are commonly used in this setting, but yield suboptimal remission rates and modest survival (Dombret 2015, Kantarjian 2012). Vadastuximab talirine (33A) is a CD33-directed antibody conjugated to 2 molecules of a pyrrolobenzodiazepine (PBD) dimer. Upon binding, 33A is internalized and transported to the lysosomes where PBD dimer is released via proteolytic cleavage of the linker, crosslinking DNA, and lea

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Olszewski, Adam J., Lasse H. Jakobsen, Graham P. Collins, et al. "The Burkitt Lymphoma International Prognostic Index (BL-IPI)." Blood 136, Supplement 1 (2020): 46–49. http://dx.doi.org/10.1182/blood-2020-134985.

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Background. BL is a rare, high-grade B-cell lymphoma that is often studied in trials with small sample sizes. Historical definitions of "low-risk BL" vary between studies, use arbitrary cutoffs for lactate dehydrogenase (LDH), and identify a small favorable group, leaving &gt;80-90% of patients (pts) in an undifferentiated "high-risk" category. A validated prognostic index will help compare study cohorts and better define good-prognosis pts for whom reduced treatment would be appropriate vs a poor-prognosis group in need of new approaches. Herein, we constructed and validated a simplified

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Pemmaraju, Naveen, Giovanni Martinelli, Elisabetta Todisco, et al. "Experience with IMGN632, a Novel CD123-Targeting Antibody-Drug Conjugate (ADC), in Frontline Patients with Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN)." Blood 138, Supplement 1 (2021): 1284. http://dx.doi.org/10.1182/blood-2021-146666.

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Abstract BACKGROUND: BPDCN is a rare, aggressive hematologic malignancy characterized by historically poor overall survival and limited therapeutic options. Despite the recent approval of tagraxofusp-erzs for BPDCN, outcomes remain suboptimal for many patients. Additionally, patients with BPDCN are older and often have co-morbidities at baseline, preventing them from receiving tagraxofusp-erzs. Therefore, novel therapies are needed in the frontline setting for patients with BPDCN. Overexpression of CD123 (IL-3Rα) is present in all BPDCN cases, thereby establishing this surface marker as a targ

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Popov, V. D., and A. Yu Bryukhanov. "History of Agroengineering Science in Saint Petersburg." Agricultural Machinery and Technologies 18, no. 1 (2024): 13–20. http://dx.doi.org/10.22314/2073-7599-2024-18-1-13-20.

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At the end of the 19th and beginning of the 20th centuries, there was a significant development in the field of domestic agricultural engineering science, which focused on the challenges associated with the creation of agricultural machinery. The integration of new technologies in agriculture necessitated a scientific foundation for these advancements, with a keen consideration for the traditional methods of land cultivation. It is posited that the origins of the scientific team at the Institute of Agroengineering and Environmental Problems of Agricultural Production can be traced back to the

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Pemmaraju, Naveen, Andrew A. Lane, Kendra L. Sweet, et al. "Results of Pivotal Phase 2 Clinical Trial of Tagraxofusp (SL-401) in Patients with Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN)." Blood 132, Supplement 1 (2018): 765. http://dx.doi.org/10.1182/blood-2018-99-118966.

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Abstract Background: Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a highly aggressive hematologic malignancy with a historical overall survival (OS) of ~8-14 months from diagnosis and no approved therapies or standard of care. Tagraxofusp (Elzonris™; SL-401) is a novel targeted therapy directed to the interleukin-3 receptor-α (CD123), a target expressed on BPDCN and other malignancies. Tagraxofusp was granted Breakthrough Therapy Designation for the treatment of patients with BPDCN, and a rolling Biologics License Application (BLA) submission to the U.S. Food and Drug Administration

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Loomis, Ormond. "Practicing Anthropology in State Folklife Programs." Practicing Anthropology 7, no. 1-2 (1985): 9–11. http://dx.doi.org/10.17730/praa.7.1-2.e826k20174x03086.

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During the last decade, roughly 40 state folk cultural, or folklife, programs have emerged throughout the United States, and more are being developed. In most states, these programs are a component of the state arts agency; elsewhere they are based in universities, in historical societies, or in other branches of state government. Examples include the Alabama Folk Arts Program, the Missouri Cultural Heritage Center, the Office of Folklife Programs in North Carolina, the Southwestern Lore Center in Arizona, and the Traditional Arts Research and Development Program of Ohio. I work with the Burea

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Aydın, Barış Can. "Development and Progress of Translation Activities in Türkiye from Late Ottoman to Early Republican Era." International Journal of Language and Translation Studies 5, no. 1 (2025): 140–65. https://doi.org/10.63673/lotus.1649494.

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This study examines the development and progression of translation activities in Türkiye from the late Ottoman Empire to the early Republican era. It also explores how the Empire’s rich cultural and linguistic diversity laid the groundwork for significant translation practices that shaped Turkish literature and intellectual thought. Furthermore, it analyses how the translation efforts that accelerated during the Republican period contributed to the construction of a new national identity in the nascent Turkish Republic. The study addresses how the translation activities carried out by the Tran

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HAN, Ye. "Research on the integration of traditional culture education into the curriculum system of English majors." Region - Educational Research and Reviews 5, no. 6 (2024): 183. http://dx.doi.org/10.32629/rerr.v5i6.1566.

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The General Secretary clearly pointed out in his speech at the 12th Collective Study of the Political Bureau of the 18th CPC Central Committee that "Chinese culture is the deepest source of our national cultural soft power, and it is an important way for us to improve our national cultural soft power". It is our historical responsibility to transmit and carry forward the excellent traditional Chinese culture. We not only want to maintain the prosperity of Chinese culture, but also to spread Chinese culture to the world and show the charm of Chinese culture to the world, and colleges and univer

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Weller, Jan Frederic, Louisa Kaufmann, Claudia Lengerke, et al. "Allogeneic Stem Cell Transplantation in Patients Aged ≥70 Years: Epidemiology, Outcomes, and Risk Factors Based on the German Registry for Stem Cell Transplantation (DRST)." Blood 138, Supplement 1 (2021): 3926. http://dx.doi.org/10.1182/blood-2021-152349.

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Abstract Introduction. Malignant diseases treated with allogeneic hematopoietic stem cell transplantation (alloHSCT) predominantly occur beyond the 7 th decade of life. Numerical age per se is not regarded an adverse risk factor in alloHSCT. In an aging society, interventions historically deemed high risk are increasingly used in elder patients. Methods. Epidemiology, outcomes and risk factors of patients aged ≥70 years undergoing alloHSCT in Germany 1999-2019 and registered with the DRST/EBMT database were analyzed retrospectively. Baseline patient, disease, and transplant data were collected

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Loges, Sonja, Grerk Sutamtewagul, Michael Heuser, et al. "Bemcentinib (Oral AXL Inhibitor) in Combination with Low-Dose Cytarabine Is Well Tolerated and Efficacious in Older Relapsed AML Patients.Updates from the Ongoing Phase II Trial (NCT02488408) and Preliminary Translational Results Indicating Bemcentinib Elicits Anti-AML Immune Responses." Blood 138, Supplement 1 (2021): 3410. http://dx.doi.org/10.1182/blood-2021-147225.

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Abstract Background: Relapsed (REL) & refractory (REF) r/r AML pts unsuitable for intensive therapy (IT) due to age or co-morbidities, have limited treatment options. Low-dose cytarabine (LDAC) demonstrated limited survival benefit (mOS ≤6 months), highlighting the significant unmet need for new treatments in this patient population. Bemcentinib (BEM) is an orally bioavailable, highly selective AXL-inhibitor. AXL is a receptor tyrosine kinase conferring poor prognosis, resistance to chemotherapy and decreased antitumor immune response. AXL is overexpressed on leukemic cells, especially in

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Osei, Jeff Dacosta, Quisha Reed-Jones, Yaw A. Twumasi, and Zhu H. Ning. "A comprehensive analysis of the alsen/st. irma lee community village in baton rouge, usa: history, challenges, and transformations." Journal of Environmental Impact and Management Policy, no. 51 (June 28, 2025): 30–43. https://doi.org/10.55529/jeimp.51.30.43.

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This study examines the Alsen/St. Irma Lee Community Village in Baton Rouge, Louisiana, focuses on its historical context, primary challenges, and transformations over time. Established in 1872 by the Freedmen's Bureau, the community has undergone significant socio-economic and environmental changes. The study highlights the community's evolution from a rural, agriculture-based economy to facing industrial pollution and economic decline. Despite these challenges, the residents have demonstrated resilience through grassroots initiatives and collaborations with nonprofit organizations. The revie

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McKiernan, Phyllis, David S. Siegel, David H. Vesole, et al. "Prospective Analysis of Bortezomib, Fludarabine and Melphalan As Conditioning Regimen Prior to Allogeneic Stem Cell Transplantation for Multiple Myeloma." Blood 132, Supplement 1 (2018): 1020. http://dx.doi.org/10.1182/blood-2018-99-117313.

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Abstract Background: Despite advances in novel myeloma treatments and autologous hematopoietic stem cell transplantation (ASCT), allogeneic HSCT (alloSCT) remains the only curative option for patients (pts) with multiple myeloma (MM). Questions remain as to the timing of alloSCT, toxicity risks and optimal conditioning regimen. The addition of bortezomib (Vel) to fludarabine (Flu) and melphalan (Mel) for conditioning prior to alloSCT is based on the demonstrated safety of Vel in combination with melphalan prior to ASCT, the synergistic effect of Vel with Mel, and the ability of Vel to selectiv

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Przespolewski, Amanda, Aaron D. Goldberg, Chetasi Talati, et al. "Safety and Efficacy of CPX-351 in Younger Patients < 60 Years Old with Secondary Acute Myeloid Leukemia: An Updated Analysis." Blood 138, Supplement 1 (2021): 1264. http://dx.doi.org/10.1182/blood-2021-153791.

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Abstract Background: Patients (pts) with secondary acute myeloid leukemia (s-AML) have poor long-term outcomes following standard induction chemotherapy with 7+3. In 2017, a liposomal cytarabine and daunorubicin formulation (CPX-351) was FDA approved for upfront treatment of s-AML based on a pivotal phase 3 trial demonstrating improved overall survival in pts aged 60-75 years old (Lancet J et al; JCO 2018). Although CPX-351 treatment was subsequently approved for s-AML regardless of age, data in younger pts &lt; 60 years who were not eligible for the pivotal trial is lacking. We sought to

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von Tresckow, Julia, Paula Cramer, Jasmin Bahlo, et al. "CLL2-BIG - a Novel Treatment Regimen of Bendamustine Followed By GA101 and Ibrutinib Followed By Ibrutinib and GA101 Maintenance in Patients with Chronic Lymphocytic Leukemia (CLL): Interim Results of a Phase II-Trial." Blood 126, no. 23 (2015): 4151. http://dx.doi.org/10.1182/blood.v126.23.4151.4151.

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Abstract Introduction: In chronic lymphocytic leukemia (CLL) treatment with anti-CD20 antibodies including obinutuzumab (GA101) and targeted drugs, such as ibrutinib, show promising efficacy and tolerability compared to standard chemoimmunotherapy. With the CLL2-BIG trial, the German CLL Study Group (GCLLSG) designed a novel combination regimen composed of obinutuzumab and ibrutinib for induction and maintenance treatment. To reduce the risk of severe infusion related reactions (IRR) during the first infusion of obinutuzumab, patients with high tumor burden receive bendamustine as debulking re

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Sallman, David A., Amy E. DeZern, David P. Steensma, et al. "Phase 1b/2 Combination Study of APR-246 and Azacitidine (AZA) in Patients with TP53 mutant Myelodysplastic Syndromes (MDS) and Acute Myeloid Leukemia (AML)." Blood 132, Supplement 1 (2018): 3091. http://dx.doi.org/10.1182/blood-2018-99-119990.

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Abstract Introduction: TP53 mutant (mTP53) MDS and AML, accounting for 5-10% of de novo MDS and 25-30% of therapy related MDS (t-MDS), represent a distinct molecular cohort with inferior outcomes. Hypomethylating agents (HMA) are preferred treatments for patients (pts) with these mutations, although with CR rates of only 20-30% and median OS of 6-12 months. APR-246 is a novel, first-in-class small molecule that selectively induces apoptosis in mTP53 cancer cells through mutant p53 protein re-activation by restoring the wild-type conformation, with single agent activity in mTP53 AML. We report

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Zuppelli, Ashley R., Michael Mancenido, Jacob Scutaru, et al. "1039. Real World Community-Based HIV Rapid Start Antiretroviral with BFTAF Versus Conventional HIV Antiretroviral Therapy Start – The RoCHaCHa Study, a Pilot Study." Open Forum Infectious Diseases 7, Supplement_1 (2020): S549—S550. http://dx.doi.org/10.1093/ofid/ofaa439.1225.

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Abstract Background Trillium Health (TH) is a FQHC in Rochester, NY providing primary and specialty care, including HIV prevention and treatment. Rapid Start ART (RSA) has been shown to decrease time to virologic suppression while increasing linkage to and retention in care. However, data on BFTAF with these benefits is limited. We aim to prove RSA with BFTAF is advantageous in time to viral load suppression, linkage to and retention in care, and patient satisfaction and acceptance. Methods We included data from ART-naive newly diagnosed PLWH enrolled between October 2018 and March 2020 with b

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Ravandi, Farhad, Megan Othus, Susan O'Brien, et al. "Multi-Center US Intergroup Study of Intensive Chemotherapy Plus Dasatinib Followed By Allogeneic Stem Cell Transplant in Patients with Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia Younger Than 60." Blood 126, no. 23 (2015): 796. http://dx.doi.org/10.1182/blood.v126.23.796.796.

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Abstract Background- Introduction of tyrosine kinase inhibitors in the treatment of patients with Philadelphia (Ph) chromosome positive (Ph+) acute lymphoblastic leukemia (ALL) has led to a significant improvement in the long term outcome of patients, in particular those who are unsuitable to undergo allogeneic stem cell transplant (alloSCT) in first complete remission (CR1). Design- This multicenter, phase II, clinical trial was conducted in 37 centers across the US to determine whether the addition of dasatinib to chemotherapy followed by an alloSCT in the eligible patients would lead to a s

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Levin, Grigoriy L. "Specialized bibliographic service in the structure of the Russian state library (1918—2018)." Bibliotekovedenie [Library and Information Science (Russia)] 68, no. 1 (2019): 85–92. http://dx.doi.org/10.25281/0869-608x-2019-68-1-85-92.

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December 16, 2018 marked the 100th anniversary of the formation of the Reference Bureau within the Library of the State Rumyantsev Museum. This date is quite rightly considered the birthday of the specialized bibliographic service of the Russian State Library (RSL). Practically from the first years, the specialized bibliographic division of the Library was considered as a complex unit integrating bibliographic service and compiling activity with the considerable elements of scientific-methodical, organizational-coordinating and even scientific-research work in the field of bibliography. Despit

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