Log in

Relevant bibliographies by topics / Burkholderia pseudomallei / Dissertations / Theses

To see the other types of publications on this topic, follow the link: Burkholderia pseudomallei.

Dissertations / Theses on the topic 'Burkholderia pseudomallei'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 dissertations / theses for your research on the topic 'Burkholderia pseudomallei.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.

1

Jones, Amanda L. "Burkholderia pseudomallei, host interactions." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq20744.pdf.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

Lowe, Carolyn Ann. "Iron regulation in Burkholderia cepacia and Burkholderia pseudomallei." Thesis, University of Sheffield, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.246990.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

Ellis, Jill Frances. "Antibody detection of Burkholderia pseudomallei and Burkholderia mallei." Thesis, Aston University, 2000. http://publications.aston.ac.uk/10974/.

Full text

Abstract:

Monoclonal and polyclonaI antibodies have been produced for use in immunological assays for the detection of Burkholderia pseudomallei and Burkholderia mallei. Monoclonal antibodies recognising a high molecular weight polysaccharide material found in some strains of both species have been shown to be effective in recognising B. pseudomallei and B. mallei and distinguishing them from other organisms. The high molecular weight polysaccharide material is thought to be the capsule of B. pseudomallei and B. mallei and may have important links with virulence. B. pseudomallei and B. mallei are known

APA, Harvard, Vancouver, ISO, and other styles

4

Senkiw, Michelle D. "Intracellular existence of Burkholderia pseudomallei." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0016/MQ49655.pdf.

Full text

APA, Harvard, Vancouver, ISO, and other styles

5

Atkins, Timothy Philip. "Virulence determinants of Burkholderia pseudomallei." Thesis, Imperial College London, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.325608.

Full text

APA, Harvard, Vancouver, ISO, and other styles

6

張健文 and Kin-man Cheung. "B-lactamases in Burkholderia pseudomallei." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2002. http://hub.hku.hk/bib/B31225792.

Full text

APA, Harvard, Vancouver, ISO, and other styles

7

Davies, Clare. "Molecular characterisation of Burkholderia pseudomallei." Thesis, University of Plymouth, 2001. http://hdl.handle.net/10026.1/2281.

Full text

Abstract:

A programme of research was carried out to attempt the molecular characterisation of the human and animal pathogen, Burkholderia pseudomallei, the causative agent of melioidosis and the newly described avirulent species, B.thailandensis for comparative purposes. Melioidosis is still little understood, and so the clinical approach to the prevention and control of melioidosis must ultimately rest upon the basic understanding of the causative organism, particularly the pathogenic properties of B.pseudomallei. A range of B.pseudomallei and B.thailandensis isolates were cultured and the extracellul

APA, Harvard, Vancouver, ISO, and other styles

8

Cheung, Kin-man. "B-lactamases in Burkholderia pseudomallei /." Hong Kong : University of Hong Kong, 2002. http://sunzi.lib.hku.hk/hkuto/record.jsp?B25205158.

Full text

APA, Harvard, Vancouver, ISO, and other styles

9

梁嘉玲 and Ka-ling Leung. "Novel molecular targets of Burkholderia pseudomallei." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2001. http://hub.hku.hk/bib/B31224726.

Full text

APA, Harvard, Vancouver, ISO, and other styles

10

Leung, Ka-ling. "Novel molecular targets of Burkholderia pseudomallei /." Hong Kong : University of Hong Kong, 2001. http://sunzi.lib.hku.hk/hkuto/record.jsp?B23440144.

Full text

APA, Harvard, Vancouver, ISO, and other styles

11

Flegg, Cameron. "Burkholderia Pseudomallei: Interaction with Host Cells." Thesis, Griffith University, 2012. http://hdl.handle.net/10072/366738.

Full text

Abstract:

Melioidosis is the serious and often fatal systemic disease of humans and animals resulting from infection from Burkholderia pseudomallei. B. pseudomallei is a Gram-negative bacillus that inhabits the soil and stagnant water of tropical and sub-tropical countries. Infection usually occurs through inhalation or inoculation though ingestion is a common route for animal infections. The disease can occur in almost any organ and symptoms are non-specific leading to common misdiagnosis. B. pseudomallei has increased prevalence for infection in immunocompromised and diabetic patients. Due to the soil

APA, Harvard, Vancouver, ISO, and other styles

12

Keith, Karen Elizabeth. "Biochemical studies and proteomics of Burkholderia pseudomallei and Burkholderia cenocepacia." Thesis, Imperial College London, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.409526.

Full text

APA, Harvard, Vancouver, ISO, and other styles

13

Duangsonk, Kwanjit. "Genomic and genetic analysis of Burkholderia pseudomallei." Thesis, University of Liverpool, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.437528.

Full text

APA, Harvard, Vancouver, ISO, and other styles

14

Jenkins, Christopher. "Investigating the lytic transglycosylases of Burkholderia pseudomallei." Thesis, University of Leicester, 2018. http://hdl.handle.net/2381/42166.

Full text

Abstract:

Peptidoglycan is a mesh like structure that is an integral part of the bacterial cell wall. Comprised of glycan chains interconnected with short peptide chains, it is responsible for protecting the bacteria from hydrostatic pressures as well as providing a scaffold for many cell wall spanning structures. Tight regulation of the synthesis, maintenance and turnover of peptidoglycan is essential to maintaining integrity of bacteria. One family of enzymes involved in the regulated cleavage of peptidoglycan are lytic transglycosylases (Ltgs). These proteins are highly conserved in bacteria and func

APA, Harvard, Vancouver, ISO, and other styles

15

Norville, Isobel Harriet. "The identification and characterisation of PPIases from Burkholderia pseudomallei and Burkholderia thailandensis." Thesis, University of Exeter, 2011. http://hdl.handle.net/10036/3152.

Full text

Abstract:

The aim of this study was to identify and characterise peptidyl-prolyl cis-trans isomerases (PPIases) from the bacterium Burkholderia pseudomallei, the causative agent of the disease melioidosis. The longer term goal was to assess their potential as vaccine candidates or antimicrobial targets. Using bioinformatic approaches, six putative FK506-binding proteins (FKBPs) proteins and three putative parvulin proteins were identified in B. pseudomallei. Of these, six were expressed and purified as recombinant proteins. The purified proteins were used to immunise BALB/c mice, with some providing pro

APA, Harvard, Vancouver, ISO, and other styles

16

Lim, J. "The characterization of the lipoprotein VacJ in Burkholderia pseudomallei and Burkholderia thailandensis." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2014. http://researchonline.lshtm.ac.uk/2124339/.

Full text

Abstract:

Burkholderia pseudomallei, the causative agent of melioidosis, has evolved multiple strategies to facilitate survival in the environment and can cause serious disease in the human host. The lipoprotein BPSL3147 (VacJ) was previously shown to be important in the growth and survival of B. pseudomallei in an in vivo mouse model and a VacJ transposon mutant was highly attenuated. This work has focused on elucidating the role of VacJ as a virulence determinant in B. pseudomallei. The gene was characterized using bioinformatic and genetic techniques, utilizing comparisons with B. thailandensis to st

APA, Harvard, Vancouver, ISO, and other styles

17

Fehlhaber, Beate. "Identifizierung und Charakterisierung von Virulenzfaktoren bei Burkholderia pseudomallei." [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=96804042X.

Full text

APA, Harvard, Vancouver, ISO, and other styles

18

Lertmemongkolchai, Ganjana. "Mechanisms of cellular immune response against Burkholderia pseudomallei." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.271142.

Full text

APA, Harvard, Vancouver, ISO, and other styles

19

Devarajoo, Shashikala Devi. "Purification of the exotoxin(s) of Burkholderia pseudomallei." Thesis, University of Salford, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.360452.

Full text

APA, Harvard, Vancouver, ISO, and other styles

20

Shalom, Gil. "Identification of macrophage-induced genes in Burkholderia pseudomallei." Thesis, University of Sheffield, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.251370.

Full text

APA, Harvard, Vancouver, ISO, and other styles

21

Donaldson, Matthew. "Antimicrobial carbohydrate vaccines : development of Burkholderia pseudomallei immunogens." Thesis, University of East Anglia, 2013. https://ueaeprints.uea.ac.uk/48103/.

Full text

Abstract:

The potential bio-terror threat posed by Burkholderia pseudomallei highlights the need for an effective vaccine. Immunisation and challenge experiments in mice have demonstrated that the capsular polysaccharide (CPS-1) of B. pseudomallei, which is composed of β-1,3-linked 6-deoxy-D-manno-heptopyranose residues, is a promising candidate for vaccine development. This thesis set out to explore routes to potential vaccine candidates for Burkholderia pseudomallei infection based on both bottom-up synthetic monosaccharide constructs and top-down CPS-1 conjugates. Initially this thesis focused on the

APA, Harvard, Vancouver, ISO, and other styles

22

Pankhania, Depesh. "The serine/threonine protein kinases of Burkholderia pseudomallei." Thesis, University of Leicester, 2015. http://hdl.handle.net/2381/32255.

Full text

Abstract:

Burkholderia pseudomallei is a Gram-negative bacterium that is endemic in tropical and sub-tropical regions. B. pseudomallei is an opportunistic pathogen and is the causative agent of the human disease, melioidosis, which accounts for 20% of all septicaemic deaths in Thailand. The phosphorylation via serine/threonine protein kinases (STKs) coordinates a vast array of signal pathways in both eukaryotic and prokaryotic organisms. In bacteria these pathways include: biofilm formation, cell wall biosynthesis, metabolism, sporulation, stress response and virulence. In this study, I identified six g

APA, Harvard, Vancouver, ISO, and other styles

23

Pramanpol, Nuttawan. "Structural studies on immunogenic proteins of Burkholderia pseudomallei." Thesis, University of Sheffield, 2013. http://etheses.whiterose.ac.uk/3807/.

Full text

APA, Harvard, Vancouver, ISO, and other styles

24

Patel, Natasha. "Experimental models of pulmonary vaccination against burkholderia pseudomallei." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.549760.

Full text

APA, Harvard, Vancouver, ISO, and other styles

25

Virginio, Camila Gomes. "Aspectos fenotÃÂpicos de amostras de Burkhoderia pseudomallei isoladas de uma microepidemia do municÃÂpio de TejuÃÂuoca-Ce." Universidade Federal do CearÃ, 2005. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=768.

Full text

Abstract:

CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superior<br>A Burkholderia pseudomallei Ã um bacilo Gram-negativo nÃo-fermentador, saprÃfita ambiental capaz de causar melioidose em homens e animais. A doenÃa Ã considerada endÃmica em diversos paÃses, entre os quais destacam-se TailÃndia e AustrÃlia. Em fevereiro de 2003, ocorreu no Brasil, o primeiro isolamento e identificaÃÃo da bactÃria em quatro crianÃas da localidade de TejuÃuoca, CearÃ. Este trabalho consiste na caracterizaÃÃo fenotÃpica de 3 amostras de B. pseudomallei originÃrias dos pacientes do municÃpio de TejuÃuoca, com o propÃsi

APA, Harvard, Vancouver, ISO, and other styles

26

Virginio, Camila Gomes. "Aspectos fenotípicos de amostras de Burkhoderia pseudomallei isoladas de uma microepidemia do município de Tejuçuoca-Ce." reponame:Repositório Institucional da UFC, 2005. http://www.repositorio.ufc.br/handle/riufc/1818.

Full text

Abstract:

VIRGINIO, Camila Gomes. Aspectos fenotípicos de amostras de burkholderia pseudomallei isoladas de uma microepidemia no municípios de Tejuçuoca-CE. 2005. 136 f. Dissertação (Mestrado em Microbiologia Médica) - Universidade Federal do Ceará. Faculdade de Medicina, Fortaleza, 2005.<br>Submitted by denise santos (denise.santos@ufc.br) on 2012-01-04T13:45:00Z No. of bitstreams: 1 2005_dis_cgvirgínio.pdf: 7687643 bytes, checksum: d6c0e4ff2f09282d3738c27cd4b0bc8f (MD5)<br>Approved for entry into archive by Eliene Nascimento(elienegvn@hotmail.com) on 2012-02-02T13:40:19Z (GMT) No. of bitstreams: 1 200

APA, Harvard, Vancouver, ISO, and other styles

27

Bandeira, Tereza de Jesus Pinheiro Gomes. "Caracterização fenotípica e genotípica, sensibilidade a antimicrobianos e detecção de genes de virulência de cepas clínicas e ambientais de Burkholderia pseudomallei." reponame:Repositório Institucional da UFC, 2011. http://www.repositorio.ufc.br/handle/riufc/5313.

Full text

Abstract:

BANDEIRA, Tereza de Jesus Pinheiro Gomes. Caracterização fenotípica e genotípica, sensibilidade a antimicrobianos e detecção de genes de virulência de cepas clínicas e ambientais de Burkholderia pseudomallei. 2011. 151 f. Tese (Doutorado em Microbiologia Médica) - Universidade Federal do Ceará. Faculdade de Medicina, Fortaleza, 2011.<br>Submitted by denise santos (denise.santos@ufc.br) on 2013-07-08T16:20:33Z No. of bitstreams: 1 2011_tese_tjpgbandeira.pdf: 2968543 bytes, checksum: 7ca158d99b2739cf86254cd483a4ca24 (MD5)<br>Approved for entry into archive by Erika Fernandes(erikaleitefernande

APA, Harvard, Vancouver, ISO, and other styles

28

Alla, Ravi Chandran Reddy. "Structural Analyses of Lipid A from Burkholderia pseudomallei and Burkholderia thailandensis by Mass Spectrometry." University of Toledo / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1440078701.

Full text

APA, Harvard, Vancouver, ISO, and other styles

29

Rolim, Dionne Bezerra. "Burkholderia pseudomallei no Estado do CearÃ: caracterizaÃÃo de reservÃrias." Universidade Federal do CearÃ, 2009. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=14171.

Full text

Abstract:

nÃo hÃ<br>A melioidose, uma enfermidade causada pelo bacilo Gram-negativo, Burkholderia pseudomallei, Ã endÃmica no sudeste da Ãsia e na AustrÃlia e tem distribuiÃÃo esporÃdica em outras partes do mundo. A doenÃa Ã descrita nas AmÃricas, sendo emergente no Brasil desde que casos em humanos sÃo bem documentados no Estado do CearÃ. Esta pesquisa pretendeu compreender melhor a ecologia da bactÃria por meios da caracterizaÃÃo de suas reservÃrias. O estudo foi realizado em uma pesquisa ambiental de B. pseudomallei no solo dos MunicÃpios de TejuÃuoca e BanabuiÃ e na realizaÃÃo de inquÃrito soro-epid

APA, Harvard, Vancouver, ISO, and other styles

30

Southern, Stephanie. "Evaluation of two novel antimicrobial targets in Burkholderia pseudomallei." Thesis, University of Southampton, 2014. https://eprints.soton.ac.uk/367092/.

Full text

Abstract:

Burkholderia pseudomallei is a Gram-negative bacterium and the causative agent of the disease melioidosis. Melioidosis is endemic in regions of Southeast Asia and northern Australia, with human infection associated with a high mortality rate. The disease can manifest in several forms, including pneumonia, septicaemia or a chronic infection which can affect multiple organs and persist for months or years. This makes treatment of B. pseudomallei infection extremely problematic, complicated further by its inherent antibiotic resistance. For this reason new antimicrobials are required that target

APA, Harvard, Vancouver, ISO, and other styles

31

Rolim, Dionne Bezerra. "Burkholderia pseudomallei no estado do Ceará : caracterização de reservárias." reponame:Repositório Institucional da UFC, 2009. http://www.repositorio.ufc.br/handle/riufc/12249.

Full text

Abstract:

ROLIM, Dionne Bezerra. Burkholderia pseudomallei no estado do Ceará : caracterização de reservárias. 2009. 156 f. Tese (Doutorado em Ciências Médicas) – Faculdade de Medicina, Universidade Federal do Ceará, Fortaleza, 2009.<br>Submitted by denise santos (denise.santos@ufc.br) on 2015-05-18T13:23:34Z No. of bitstreams: 1 2009_ tese_dbrolim.pdf: 3141910 bytes, checksum: 3afbdab5e7f63e729d72f0de548bd1f4 (MD5)<br>Approved for entry into archive by denise santos(denise.santos@ufc.br) on 2015-05-18T13:27:21Z (GMT) No. of bitstreams: 1 2009_ tese_dbrolim.pdf: 3141910 bytes, checksum: 3afbdab5e7f63e72

APA, Harvard, Vancouver, ISO, and other styles

32

Zainal, Abidin Nurhamimah. "Studies on the intracellular life of the melioidosis pathogen Burkholderia pseudomallei." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/31336.

Full text

Abstract:

Melioidosis, caused by the environmental Gram negative bacillus Burkholderia pseudomallei, is an emerging infectious disease affecting both animals and humans. B. pseudomallei has the ability to enter the host cell and escape from the phagosome. Once in the cytoplasm, the pathogen proliferates and expresses a virulence-associated protein known as BimA which polymerises cellular actin at the pole of the bacterium to promote its movement inter- and intracellularly, a process known as actin-based motility. This actin-based motility is also used as a strategy to evade host immune responses and sur

APA, Harvard, Vancouver, ISO, and other styles

33

Jitprasutwit, Niramol. "Investigating the role of IQGAP1 in intracellular life of Burkholderia pseudomallei." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/31142.

Full text

Abstract:

Burkholderia pseudomallei is a Gram-negative intracellular bacterium that causes melioidosis, a serious disease of humans and animals in tropical countries. This pathogen can subvert the host cell actin machinery by a process known as actibased motility, for promoting its movement both within and between cells. The bacterial factor required for this process is known as BimA (Burkholderia intracellular motility A). Intracytoplasmic bacterial pathogens use distinct mechanisms for actin-based motility, hijacking host cytoskeletal proteins for their benefit. However, the molecular mechanism by whi

APA, Harvard, Vancouver, ISO, and other styles

34

Valente, Lívia Gurgel do Amaral. "Identificação de melanina em cepas clínicas e ambientais de Burkholderia pseudomallei e atividade in vitro do farnesol como inibidor de β-lactamases". reponame:Repositório Institucional da UFC, 2012. http://www.repositorio.ufc.br/handle/riufc/8692.

Full text

Abstract:

VALENTE, Livia Gurgel do Amaral. Identificação de melanina em cepas clínicas e ambientes de Burkholderia pseudomallei e atividade in vitro do farnesol como inibidor de ß-lactamases. 2012. 81 f. Dissertação (Mestrado em Microbiologia Médica) - Universidade Federal do Ceará, Fortaleza, 2012.<br>Submitted by denise santos (denise.santos@ufc.br) on 2014-08-12T16:03:59Z No. of bitstreams: 1 2012_dis_lgavalente.pdf: 2099115 bytes, checksum: 202d0f130cefb452d49f8b0f3f7f0594 (MD5)<br>Approved for entry into archive by denise santos(denise.santos@ufc.br) on 2014-08-12T16:04:48Z (GMT) No. of bitstreams:

APA, Harvard, Vancouver, ISO, and other styles

35

Correia, Giovanna Riello Barbosa. "Inhibitory effect in vitro of farnesol against Burkholderia pseudomallei biofilms." Universidade Federal do CearÃ, 2015. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=16814.

Full text

Abstract:

CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superior<br>A intrÃnseca resistÃncia apresentada pela bactÃria Burkholderia pseudomallei Ã um grave empecilho para o tratamento da melioidose. Muitas pesquisas focam na busca de adjuvantes que aumentem a sensibilidade desta bactÃria aos antimicrobianos. Nesse contexto, a aÃÃo inibitÃria do farnesol frente Ãs cepas de B. pseudomallei, na forma planctÃnica, jÃ foi relatada em estudo prÃvio. Diante disso, esse estudo objetivou analisar a atividade in vitro do farnesol contra cepas de B. pseudomallei na forma de biofilme. Aliado Ã anÃlise da aÃÃo

APA, Harvard, Vancouver, ISO, and other styles

36

Pongmala, Khemngeun. "Influence des propriétés physiques et chimiques du sol et de leur variation saisonnière sur l'occurrence et la distribution de Burkholderia pseudomallei dans une rizière au centre du Laos." Electronic Thesis or Diss., Toulouse 3, 2022. http://thesesups.ups-tlse.fr/5342/.

Full text

Abstract:

Burkholderia pseudomallei (BP) bactérie commune des sols tropicaux, provoque une maladie grave, la mélioïdose. Cette thèse, basée sur un travail de terrain dans le centre de la RDP Lao où BP est endémique, vise à clarifier les déterminants de la distribution de BP dans le sol en fonction des conditions biogéochimiques du sol et climatiques, à des échelles emboîtées. PB a été identifiée dans le sol jusqu'à 300 cm de profondeur, à des concentrations variables (maximales en dessous de 100 cm), à la fois à l'échelle du millimètre, en lien avec l'état d'oxydation du fer, et à l'échelle du profil du

APA, Harvard, Vancouver, ISO, and other styles

37

Gasqué, Mégane. "Étude de l'occurence de Burkholderia pseudomallei dans la région Antilles-Guyane." Electronic Thesis or Diss., Sorbonne université, 2024. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2024SORUS169.pdf.

Full text

Abstract:

Burkholderia pseudomallei est l'agent pathogène responsable de la mélioïdose, une infection opportuniste. Elle est endémique en Asie du Sud, en Asie du Sud-Est et dans le Nord de l'Australie. En 2015, le nombre de cas annuels de mélioïdose était estimé à 165 000 dans le monde. Cette bactérie a la capacité d'infecter l'homme et les animaux par inhalation, ingestion ou contact cutané. Depuis plusieurs années, des cas humains de mélioïdose sont signalés en dehors des zones endémiques connues, notamment dans la région Antilles-Guyane. Depuis 1993, vingt cas humains de mélioïdose ont été recensés e

APA, Harvard, Vancouver, ISO, and other styles

38

Day, Matthew. "Structural studies on protein targets from the pathogenic bacterium Burkholderia pseudomallei." Thesis, University of Sheffield, 2012. http://etheses.whiterose.ac.uk/3396/.

Full text

Abstract:

The main body of this thesis deals with a small-scale structural genomics project for proteins from the bacterium, Burkholderia pseudomallei. Potential pathogenicity determinants were selected based on their possession of at least one of two criteria. The first was their expression in the pathogenic Burkholderia pseudomallei but not the closely related, nonpathogenic Burkholderia thailandensis. The second required their expression be controlled as part of a stress response, which controls other known virulence factors. Of the nine selected targets, five were successfully overexpressed, purifie

APA, Harvard, Vancouver, ISO, and other styles

39

Sangiambut, Sutha. "Cloning, expression and characterisation of potential therapeutic targets of Burkholderia pseudomallei." Thesis, Imperial College London, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.271682.

Full text

APA, Harvard, Vancouver, ISO, and other styles

40

Marshall, Laura Emma. "The identification and characterisation of novel antimicrobial targets in Burkholderia pseudomallei." Thesis, University of Exeter, 2012. http://hdl.handle.net/10036/4074.

Full text

Abstract:

The bacterium Burkholderia pseudomallei causes the disease melioidosis, a significant public health threat in endemic regions and is a potential biowarfare agent. Treatment of melioidosis is intensive and prolonged and there is no licensed vaccine to protect against it. The aim of this study was to characterise novel targets for antimicrobials to improve treatment of melioidosis. A holistic down selection process was undertaken in order to identify a range of possible novel and exploitable antimicrobial targets in Burkholderia pseudomallei. Four targets: FtsA, FtsZ, MraW and TonB were selected

APA, Harvard, Vancouver, ISO, and other styles

41

Mahfouz, Magdy Elsayed. "Molecular characterisation of a two-component regulatory system from Burkholderia pseudomallei." Thesis, University of Plymouth, 2001. http://hdl.handle.net/10026.1/2538.

Full text

Abstract:

Studies were undertaken to clone and characterise a two-component regulatory system from a clinical isolate (204) of the human and animal pathogen Burkholderia pseudomallei. A number of genomic libraries were constructed in E. coli host-vector systems and screened for the presence of a two-component system using oligonucleotide probes based on nucleotide sequence homology. Fragments of genomic DNA were cloned and sequenced and found to possess two open reading frames (ORFs) that overlap with a single nucleotide and are believed to encode a novel two-component regulatory system. A possible prom

APA, Harvard, Vancouver, ISO, and other styles

42

Baldwin, Victoria Mae. "Next generation approaches to polysaccharide preparation for Burkholderia pseudomallei vaccine development." Thesis, University of Exeter, 2016. http://hdl.handle.net/10871/30158.

Full text

Abstract:

Burkholderia pseudomallei is the aetiological agent of melioidosis and a potential bioterror threat. Infections are difficult to treat due to extensive antibiotic resistance and there is no prophylactic vaccine available. Studies have shown that the capsular polysaccharide (CPS) of B. pseudomallei is a virulence factor, immunogen and candidate antigen for a glycoconjugate vaccine. However, polysaccharides are complex to synthesise. One approach is to genetically engineer Escherichia coli to express the CPS; however, previous attempts at cloning the CPS coding locus from B. pseudomallei into E.

APA, Harvard, Vancouver, ISO, and other styles

43

Vander, Broek Charles William. "Subversion of host cellular processes by the melioidosis pathogen, Burkholderia pseudomallei." Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/25402.

Full text

Abstract:

Burkholderia pseudomallei is an intracellular pathogen and the causative agent of melioidosis, a severe disease of humans and animals. One of the virulence factors critical for early stages of infection is the Burkholderia secretion apparatus (Bsa) Type 3 Secretion System (T3SS), a molecular syringe that injects bacterial proteins, called effectors, into eukaryotic cells where they subvert cellular functions to the benefit of the bacteria. Although the Bsa T3SS itself is known to be important for host cell invasion, intracellular replication, and virulence, only a few genuine effector proteins

APA, Harvard, Vancouver, ISO, and other styles

44

Butt, Aaron Trevor. "Identification and characterisation of toxin-antitoxin systems (TA) in Burkholderia pseudomallei." Thesis, University of Exeter, 2013. http://hdl.handle.net/10871/9303.

Full text

Abstract:

The aim of this study was to identify and characterise type II toxin-antitoxin (TA) systems in Burkholderia pseudomallei, the causative agent of the human disease melioidosis. 8 putative TA systems were identified within the genome of B. pseudomallei K96243. 5 of these were located witihn genome islands. Of the candidate toxins, BPSL0175 (RelE1) or BPSS1060 (RelE2) caused growth to cease when expressed in Escherichia coli, whereas expression of BPSS0390 (HicA) or BPSS1584 (HipA) (in an E. coli ΔhipBA background) caused a reduction in the number of culturable bacteria. HicA also caused growth a

APA, Harvard, Vancouver, ISO, and other styles

45

Schmidt, Imke [Verfasser]. "Rolle von antioxidativen Enzymen bei Infektionen mit Burkholderia pseudomallei / Imke Schmidt." Greifswald : Universitätsbibliothek Greifswald, 2015. http://d-nb.info/1073726088/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

46

Legutki, Joseph Barten. "Analysis of the immunogenicity of peptide mimotopes of burkholderia pseudomallei exopolysaccharide." The Ohio State University, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=osu1163549512.

Full text

APA, Harvard, Vancouver, ISO, and other styles

47

Santanirand, Pitak. "The role of cytokines in the immune response to Burkholderia pseudomallei." Thesis, London School of Hygiene and Tropical Medicine (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.391948.

Full text

APA, Harvard, Vancouver, ISO, and other styles

48

Boddey, Justin Andrew. "Molecular and cellular characterisation of Burkholderia pseudomallei interactions with host cells." Thesis, Griffith University, 2006. http://hdl.handle.net/10072/365664.

Full text

Abstract:

Burkholderia pseudomallei is a bacterial pathogen that causes a broad spectrum of serious and oftenfatal diseases, collectively termed melioidosis. B. pseudomallei is capable of interacting specifically with host cells; it can adhere, invade, and survive and replicate intracellularly and induce the formation of multinucleated giant cells (MNGCs). While recent work has begun characterising these interactions at the molecular level, much is still unknown. In this work, B. pseudomallei interactions with eukaryotic cells were investigated at the cellular and molecular level. Many putative loci wer

APA, Harvard, Vancouver, ISO, and other styles

49

Alharbi, Mona. "Structural investigation of the GAF domain protein BPSL2418 from Burkholderia pseudomallei." Thesis, University of Sheffield, 2014. http://etheses.whiterose.ac.uk/8314/.

Full text

Abstract:

A new family of methionine-sulfoxide reductase (Msr) was recently discovered, and was named free methionine sulfoxide reductase (fRMsr). This family includes enzymes with a reductase activity toward the free R isomer of a methionine sulfoxide substrate. The fRMsrs have a GAF domain topology, a domain, which was previously identified as having in some cases a cyclic nucleotide phosphodiesterase activity. The classification of fRMsrs as GAF domains revealed a new function can be added to the GAF domain family. Interestingly the four members identified in the fRMsr family share the GAF domain str

APA, Harvard, Vancouver, ISO, and other styles

50

Correia, Giovanna Riello Barbosa. "Efeito inibitório in vitro do composto farnesol frente ao biofilme de Burkholderia pseudomallei." reponame:Repositório Institucional da UFC, 2015. http://www.repositorio.ufc.br/handle/riufc/16552.

Full text

Abstract:

CORREIA, G. R. B. Efeito inibitório in vitro do composto farnesol frente ao biofilme de Burkholderia pseudomallei. 2015. 88 f. Dissertação (Mestrado em Microbiologia Médica) - Faculdade de Medicina, Universidade Federal do Ceará, Fortaleza, 2015.<br>Submitted by Erika Fernandes (erikaleitefernandes@gmail.com) on 2016-05-02T15:58:57Z No. of bitstreams: 1 2015_dis_grbcorreia.pdf: 1260823 bytes, checksum: 8ebde2fdd525176303b72981cc66cfa0 (MD5)<br>Approved for entry into archive by Erika Fernandes (erikaleitefernandes@gmail.com) on 2016-05-02T15:59:07Z (GMT) No. of bitstreams: 1 2015_dis_grbcorrei

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!