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1

Slevin, Finbar, Matthew Beasley, Jim Zhong, et al. "A feasibility study of hyoscine butylbromide (buscopan) to improve image quality of cone beam computed tomography during abdominal/pelvic Stereotactic Ablative Radiotherapy." BJR|Open 3, no. 1 (2021): 20210045. http://dx.doi.org/10.1259/bjro.20210045.

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Objectives: Cone beam computed tomography (CBCT) is used for image guidance of stereotactic ablative radiotherapy (SABR), but it is susceptible to bowel motion artefacts. This trial evaluated the impact of hyoscine butylbromide (buscopan) on CBCT image quality and its feasibility within a radiotherapy workflow. Methods: A single-centre feasibility trial (ISRCTN24362767) was performed in patients treated with SABR for abdominal/pelvic oligorecurrence. Buscopan was administered to separate cohorts by intramuscular (IM) or intravenous (i.v.) injection on alternate fractions, providing within-pati
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2

Hammam, Hekmat, Arushi Arvind, Susan Khalafallah, Ghassan Kloub, Shrutika Parekh, and Sameer Kapoor. "EFFECT OF BUSCOPAN COMPARED WITH GLUCAGON DURING GASTROSCOPY, COLONOSCOPY, AND ERCP- A NARRATIVE REVIEW." International Journal of Advanced Research 12, no. 08 (2024): 310–14. http://dx.doi.org/10.21474/ijar01/19256.

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Objective: To provide a comprehensive overview of Buscopan and glucagon, comparing their mechanisms, efficacy, safety profiles, and guidelines for use in gastrointestinal endoscopy and ERCP. This review aims to offer insights into the optimal use of these agents, emphasizing the importance of personalized medicine in endoscopic practice. A narrative review was conducted, analyzing studies, clinical trials, and guidelines from prominent gastroenterological associations, including the Canadian Association of Gastroenterology (CAG) and the British Society of Gastroenterology (BSG) to compare the
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3

Doran, R. M. L., R. Gray, and J. P. Virjee. "Buscopan and glaucoma." British Journal of Radiology 60, no. 712 (1987): 417. http://dx.doi.org/10.1259/0007-1285-60-712-417-a.

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4

Zitvast, Hester. "Buscopan tegen Reutelen." Nursing 29, no. 6 (2023): 32–35. http://dx.doi.org/10.1007/s41193-023-0736-0.

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5

Treweeke, P., and N. K. Barrett. "Allergic reaction to Buscopan." British Journal of Radiology 60, no. 712 (1987): 417. http://dx.doi.org/10.1259/0007-1285-60-712-417-b.

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6

Mackway-Jones, K. "Buscopan (hyoscine butylbromide) in abdominal colic." Emergency Medicine Journal 20, no. 3 (2003): 267. http://dx.doi.org/10.1136/emj.20.3.267.

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7

Anderson, R., and J. Lee. "Buscopan for oesophageal food bolus impaction." Emergency Medicine Journal 24, no. 5 (2007): 360–61. http://dx.doi.org/10.1136/emj.2007.048496.

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8

Thomas, L., C. Webb, S. Duvvi, T. Jones, and K. T. V. Reddy. "Is buscopan effective in meat bolus obstruction?" Clinical Otolaryngology 30, no. 2 (2005): 183–85. http://dx.doi.org/10.1111/j.1365-2273.2004.00931.x.

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9

Wilson, C. M., N. Lillywhite, B. Matta, P. Mills, and S. Wiltshire. "Intravenous buscopan for analgesia following laparoscopic sterilisation." Anaesthesia 54, no. 4 (1999): 389–92. http://dx.doi.org/10.1046/j.1365-2044.1999.00858.x.

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10

Hartnell, G. G., and A. P. Hemingway. "Contrast medium reactions—does Buscopan reduce them?" British Journal of Radiology 61, no. 727 (1988): 652. http://dx.doi.org/10.1259/0007-1285-61-727-652-a.

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11

Latli, Bachir, Michael Stiasni, Matt Hrapchak, et al. "Buscopan labeled with carbon-14 and deuterium." Journal of Labelled Compounds and Radiopharmaceuticals 59, no. 13 (2016): 557–64. http://dx.doi.org/10.1002/jlcr.3463.

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12

Chopra, K., D. Westaby, and I. Murray-Lyon. "Why use Buscopan during diagnostic upper gastrointestinal endoscopy?" Gut 38, no. 3 (1996): 473. http://dx.doi.org/10.1136/gut.38.3.473.

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13

Fink, A. M., and G. W. Aylward. "Buscopan and glaucoma: A survey of current practice." Clinical Radiology 50, no. 3 (1995): 160–64. http://dx.doi.org/10.1016/s0009-9260(05)83047-8.

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14

Aarts, Francine. "5 Feiten en fabels over reutelen en Buscopan." Nursing 30, no. 4 (2024): 34–37. http://dx.doi.org/10.1007/s41193-024-1153-8.

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15

Khayyat, Yasir Mohammed. "Pharmacological Management of Esophageal Food Bolus Impaction." Emergency Medicine International 2013 (2013): 1–6. http://dx.doi.org/10.1155/2013/924015.

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Background. Soft esophageal bolus impaction is an emergency that requires skilled endoscopic removal if persistent obstructive symptoms do not resolve spontaneously after careful observation. Expedited care of these patients is crucial to avoid respiratory and mechanical complications. Other possible options for management include medical agents used to manage it prior to performing endoscopy if access to endoscopy was not available or declined by the patient.Aim. To review the available pharmacological and other nonmedicinal options and their mechanism of relief for soft esophageal impaction.
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16

Lee, Thomas, John Anderson, Siwan Thomas-Gibson, and Colin Rees. "Use of intravenous hyoscine butylbromide (Buscopan) during gastrointestinal endoscopy." Frontline Gastroenterology 9, no. 3 (2017): 183–84. http://dx.doi.org/10.1136/flgastro-2017-100877.

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17

Basavaraj, S., K. R. Penumetcha, H. R. Cable, and N. Umapathy. "Buscopan in oesophageal food bolus: is it really effective?" European Archives of Oto-Rhino-Laryngology 262, no. 7 (2004): 524–27. http://dx.doi.org/10.1007/s00405-004-0852-7.

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18

Fallon, R. J., J. F. Quirke, J. Limper, C. Justus, and H. Larkin. "The effects of Buscopan compositum on calf nutritional diarrhoea." Veterinary Research Communications 15, no. 6 (1991): 475–82. http://dx.doi.org/10.1007/bf00346547.

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19

Strano-Rossi, Sabina, Serena Mestria, Giorgio Bolino, Matteo Polacco, Simone Grassi, and Antonio Oliva. "Scopolamine fatal outcome in an inmate after buscopan® smoking." International Journal of Legal Medicine 135, no. 4 (2021): 1455–60. http://dx.doi.org/10.1007/s00414-021-02583-2.

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AbstractScopolamine is an alkaloid which acts as competitive antagonists to acetylcholine at central and peripheral muscarinic receptors. We report the case of a 41-year-old male convict with a 27-year history of cannabis abuse who suddenly died in the bed of his cell after having smoked buscopan® tablets. Since both abuse of substances and recent physical assaults had been reported, we opted for a comprehensive approach (post-mortem computed tomography CT (PMCT), full forensic autopsy, and toxicology testing) to determine which was the cause of the death. Virtopsy found significant cerebral e
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20

Habib, A., P. Sharpe, S. Anderson, S. Francis, A. C. Davidson, and G. Smith. "Buscopan® for the treatment of pain after laparoscopic sterilisation." Anaesthesia 56, no. 2 (2001): 174–76. http://dx.doi.org/10.1046/j.1365-2044.2001.01528-2.x.

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21

Rajah, R. Ranjit. "Effects of buscopan on gastro-oesophageal reflux and hiatus hernia." Clinical Radiology 41, no. 4 (1990): 250–52. http://dx.doi.org/10.1016/s0009-9260(05)81659-9.

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22

Bruzzi, John F., Alan C. Moss, Darren D. Brennan, Padraic MacMathuna, and Helen M. Fenlon. "Efficacy of IV Buscopan as a muscle relaxant in CT colonography." European Radiology 13, no. 10 (2003): 2264–70. http://dx.doi.org/10.1007/s00330-003-2012-7.

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23

Bruzzi, John F., Alan C. Moss, Darren D. Brennan, Padraic MacMathuna, and Helen M. Fenlon. "Efficacy of IV Buscopan as a muscle relaxant in CT colonography." European Radiology 14, no. 4 (2004): 756. http://dx.doi.org/10.1007/s00330-004-2242-3.

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24

Ramya Narappagari, Sree, and Himabindu Himabindu. "EFFECT OF HYOSCINE BUTYLBROMIDE (BUSCOPAN) AS CERVICAL SPASMOLYTIC AGENT IN LABOUR." Journal of Evolution of Medical and Dental Sciences 5, no. 90 (2016): 6670–74. http://dx.doi.org/10.14260/jemds/2016/1509.

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25

Milner, A. "Near-fatal outcome after administration of hyoscine-N-butylbromide (Buscopan®)." Southern African Journal of Anaesthesia and Analgesia 16, no. 4 (2010): 38–41. http://dx.doi.org/10.1080/22201173.2010.10872697.

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26

Sharma, Sanjiv, Mira Rajani, Anil Khosla, Nalinikant Misra, and R. K. Goulatia. "The influence of Buscopan on adverse reactions to intravascular contrast media." British Journal of Radiology 62, no. 744 (1989): 1056–58. http://dx.doi.org/10.1259/0007-1285-62-744-1056.

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27

Sissons, G. R. J., A. McQueenie, and M. Mantle. "The ocular effects of hyoscine-n-butylbromide (“Buscopan”) in radiological practice." British Journal of Radiology 64, no. 763 (1991): 584–86. http://dx.doi.org/10.1259/0007-1285-64-763-584.

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28

Lee, Hyuk. "Unexpected anterograde amnesia associated with Buscopan used as a predmedication for endocscopy." World Journal of Gastroenterology 13, no. 28 (2007): 3895. http://dx.doi.org/10.3748/wjg.v13.i28.3895.

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29

Aggarwal, Pakhee, Vijay Zutshi, and Swaraj Batra. "Role of hyoscine N-butyl bromide (HBB, buscopan®) as labor analgesic." Indian Journal of Medical Sciences 62, no. 5 (2008): 179. http://dx.doi.org/10.4103/0019-5359.40982.

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30

Bourdoumis, A., T. Stasinou, G. Papadopoulos, and N. Buchholz. "The evidence for using hyoscine N-butylbromide (Buscopan®) in ureteric obstruction." International Journal of Clinical Practice 68, no. 9 (2014): 1174. http://dx.doi.org/10.1111/ijcp.12506.

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31

Rao, Akshay, Fariha Sitheeque, Sonja Gustafson, Macy Lu, and Marita Prior. "MR enterography – Impact on image quality between single‐ versus split‐dose Buscopan." Journal of Medical Imaging and Radiation Oncology 64, no. 3 (2020): 331–37. http://dx.doi.org/10.1111/1754-9485.13033.

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32

Hess. "Medikamentöse Therapie der akuten Nierenkolik - es gibt mehr als Schwemmen und Buscopan®..." Praxis 100, no. 5 (2011): 293–97. http://dx.doi.org/10.1024/1661-8157/a000450.

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Die Nierenkolik entsteht bei festsitzendem Ureterstein durch eine Hyperperistaltik des Ureters. Der Uretertonus wird u.a. durch alpha-Rezeptoren (Kontraktion), beta-Rezeptoren (Relaxation) und Prostaglandine (PG F2alpha: Kontraktion, PG E1/E2: Relaxation) moduliert. In der Notfalltherapie der Nierenkolik sind nichtsteroidale Antirheumatika (NSAR) sehr effektiv (cave Kontraindikationen!). Gleiches gilt für Metamizol, während Buscopan® in Studien Placebo nicht überlegen ist. Bei stärksten nicht nachlassenden Schmerzen kommen Opioide zum Einsatz. alpha-Blocker und Kalziumantagonisten erweitern de
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33

Basavaraj, S., E. K. Reddy, J. Dempster, and K. T. V. Reddy. "Buscopan in food bolus obstruction of oesophagus: a randomised controlled single blinded study." Clinical Otolaryngology 32, no. 3 (2007): 229. http://dx.doi.org/10.1111/j.1365-2273.2007.01419_5.x.

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34

Krueger, D., K. Michel, S. Allam, et al. "Effect of hyoscine butylbromide (Buscopan®) on cholinergic pathways in the human intestine." Neurogastroenterology & Motility 25, no. 8 (2013): e530-e539. http://dx.doi.org/10.1111/nmo.12156.

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35

Goei, R., M. Nix, A. H. Kessels, and M. P. M. Ten Tusscher. "Use of antispasmodic drugs in double contrast barium enema examination: Glucagon or buscopan?" Clinical Radiology 50, no. 8 (1995): 553–57. http://dx.doi.org/10.1016/s0009-9260(05)83191-5.

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36

Poonai, N., S. Elsie, K. Kumar, et al. "LO36: Hyoscine butylbromide (Buscopan) for abdominal pain in children: a randomized controlled trial." CJEM 21, S1 (2019): S20. http://dx.doi.org/10.1017/cem.2019.79.

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Introduction: Abdominal pain is one of the most frequent reasons for an emergency department (ED) visit. Most cases are functional and no therapy has proven effective. Our objective was to determine if hyoscine butylbromide (HBB) (BuscopanTM) is effective for children who present to the ED with functional abdominal pain. Methods: We conducted a randomized, blinded, superiority trial comparing HBB 10 mg plus acetaminophen placebo to oral acetaminophen 15 mg/kg (max 975 mg) plus HBB placebo using a double-dummy approach. We included children 8-17 years presenting to the ED at London Health Scien
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37

Poonai, Naveen, Sharlene Elsie, Kriti Kumar, et al. "116 Hyoscine butylbromide (Buscopan) for abdominal pain in children: a randomized controlled trial." Paediatrics & Child Health 24, Supplement_2 (2019): e44-e45. http://dx.doi.org/10.1093/pch/pxz066.115.

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38

Lim, Soon Tjin, Timothy Yates, Di Liang, and Heather Angus-Leppan. "Out of sight: a lesson in drug errors." Practical Neurology 20, no. 3 (2020): 243–45. http://dx.doi.org/10.1136/practneurol-2019-002301.

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A 76-year-old man developed recurrent encephalopathy, visual disturbance, myoclonus, generalised seizures and atonic drop attacks on a background of a gastrectomy for adenocarcinoma and stable chronic lymphocytic leukaemia. He presented to three different hospitals and was admitted twice, with normal investigations. His symptoms transiently improved during each admission (and with starting levetiracetam) but recurred each time on hospital discharge. Subsequent careful inspection of his medication box identified that his community pharmacy had in error been dispensing baclofen 80 mg per day ins
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39

Slevin, Finbar, Matthew Beasley, Jim Zhong, et al. "A feasibility trial of Buscopan to improve cone-beam CT during abdominal/pelvic SABR." Clinical Oncology 34 (September 2022): e1. http://dx.doi.org/10.1016/j.clon.2022.08.004.

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40

Petrova, Andriana, Chloe Lauffer, Victoria Shard, Lucinda Melcher, Antke Hagena, and Manoj Nair. "The use of Hyoscine (Buscopan) to manage a high-output stoma: A case report." Intestinal Failure 1 (January 2024): 100001. http://dx.doi.org/10.1016/j.intf.2024.100001.

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41

SIROHIWAL, Daya, Krishna DAHIYA, and Mandira DE. "Efficacy of hyoscine-N-butyl bromide (Buscopan) suppositories as a cervical spasmolytic agent in labour." Australian and New Zealand Journal of Obstetrics and Gynaecology 45, no. 2 (2005): 128–29. http://dx.doi.org/10.1111/j.1479-828x.2005.00359.x.

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42

Asao, T., H. Kuwano, M. Ide, et al. "Spasmolytic Effect of Peppermint Oil in Barium During Double-contrast Barium Enema Compared with Buscopan." Clinical Radiology 58, no. 4 (2003): 301–5. http://dx.doi.org/10.1016/s0009-9260(02)00532-9.

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43

Zaman, Qamar, Aftab Khan, Daniel Thomas, Rajab Kerwat, Hamid Khawaja, and John Payne. "The impact of intravenous Buscopan on polyp detection rates and patient discomfort levels during colonoscopy." International Journal of Surgery 12 (November 2014): S31. http://dx.doi.org/10.1016/j.ijsu.2014.07.123.

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44

Namdeo, Dr Tupkar Amruta, Dr Jeevitha K. J., and Dr Prabha Ganapathy. "Effect of hyoscine–n-butyl bromide (Buscopan) rectal suppository in active phase of labour in primigravida." Obsgyne Review: Journal of Obstetric and Gynecology 5, no. 3 (2019): 147–52. http://dx.doi.org/10.17511/joog.2019.i03.04.

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45

A.O, Akintomide, Eduwem D.U, Ikpeme A.A, and Bassey D.E. "Tubal assessment with Hysterosalpingography following routine Intravenous Buscopan: A need to avoid unnecessary radiation and discomfort." IOSR Journal of Dental and Medical Sciences 15, no. 07 (2016): 75–81. http://dx.doi.org/10.9790/0853-1507107581.

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46

Papadopoulos, George, Andreas Bourdoumis, Stefanos Kachrilas, Christian Bach, Noor Buchholz, and Junaid Masood. "Hyoscine N-Butylbromide (Buscopan®) in the Treatment of Acute Ureteral Colic: What Is the Evidence?" Urologia Internationalis 92, no. 3 (2014): 253–57. http://dx.doi.org/10.1159/000358015.

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47

Oliveira, Helena G., Guilherme Gomes, José J. Morlin Jr, Cláudio J. Von Zuben, and Arício X. Linhares. "The Effect of Buscopan®on the Development of the Blow FlyChrysomya megacephala(F.) (Diptera: Calliphoridae)." Journal of Forensic Sciences 54, no. 1 (2009): 202–6. http://dx.doi.org/10.1111/j.1556-4029.2008.00926.x.

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48

H Aldahhan, Fouad, Faiz A Alwaeely, and Fawzia Raheem. "THE EVALUATION OF THE EFFECT OF BUSCOPAN (HYOSCINE-N-BUTYL BROMIDE) ON THE DURATION OF LABOUR." Basrah Journal of Surgery 17, no. 2 (2011): 25–29. http://dx.doi.org/10.33762/bsurg.2011.55375.

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49

Ertekin, Ayşe, Emre Atay, Erhan Bozkurt, and Esra Aslan. "Effect of buscopan, a compound that alleviates cramps, on the developing nervous system of the chick embryo." Birth Defects Research 113, no. 15 (2021): 1140–51. http://dx.doi.org/10.1002/bdr2.1929.

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50

Slevin, F., M. Beasley, J. Zhong, et al. "OC-0536 A feasibility trial of buscopan to improve cone beam CT image quality during abdominal/pelvic SABR." Radiotherapy and Oncology 161 (August 2021): S423—S424. http://dx.doi.org/10.1016/s0167-8140(21)06962-0.

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