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Journal articles on the topic 'BWR1'

Author: Grafiati

Published: 6 September 2023

Last updated: 31 July 2025

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1

Nilsson, Tina, Anna Sjöblom, Maria G. Masucci, and Lars Rymo. "Viral and Cellular Factors Influence the Activity of the Epstein-Barr Virus BCR2 and BWR1 Promoters in Cells of Different Phenotype." Virology 193, no. 2 (1993): 774–85. http://dx.doi.org/10.1006/viro.1993.1186.

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LU, TIEN-FU. "MODELING FOR STOCKPILE OPERATIONS ASSOCIATED WITH BULK SOLID MATERIALS USING BUCKET WHEEL RECLAIMER." International Journal of Information Acquisition 07, no. 04 (2010): 357–73. http://dx.doi.org/10.1142/s0219878910002270.

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Bucket wheel reclaimer (BWR) is one of the main equipment which has been widely used for stacking/reclaiming bulk materials (i.e., iron ore and coal) in ports, iron-steel plants, coal storages, and power stations onto/from stockpiles by mining industry. Generally speaking, current BWRs are mostly manually operated, remotely operated, or automated to simply follow predefined trajectory patterns for stacking and reclaiming operations. BWRs are indeed very large in size, heavy in weight, expensive in price, and slow in motion. It is commonly agreed in the industry that the current stacking/reclai

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Altiok, E., J. Minarovits, L. F. Hu, B. Contreras-Brodin, G. Klein, and I. Ernberg. "Host-cell-phenotype-dependent control of the BCR2/BWR1 promoter complex regulates the expression of Epstein-Barr virus nuclear antigens 2-6." Proceedings of the National Academy of Sciences 89, no. 3 (1992): 905–9. http://dx.doi.org/10.1073/pnas.89.3.905.

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Olvera-Guerrero, Omar Alejandro, Alfonso Prieto-Guerrero, and Gilberto Espinosa-Paredes. "A Novel Nonlinear BWR Stability Indicator Based on the Sample Entropy." Science and Technology of Nuclear Installations 2018 (November 1, 2018): 1–13. http://dx.doi.org/10.1155/2018/9852925.

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BWRs are thus far the simplest energy systems to transform fission energy into electrical power. However, there are still many aspects in their operation that, under certain conditions, may induce BWR unstable behavior. The default indicator to study BWR unstable behavior is the Decay Ratio (DR). However, due to the fact that BWRs show very complex responses under instability and responses that may even be chaotic, the DR might not be a suitable choice to rely on to accommodate for such intricate behavior. In this work a novel methodology based on the Sample entropy (SampEn) and the noise-assi

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LANGE, CARSTEN, DIETER HENNIG, and ANTONIO HURTADO. "A NOVEL RESULT IN THE FIELD OF NONLINEAR STABILITY ANALYSIS OF BOILING WATER REACTORS." International Journal of Bifurcation and Chaos 22, no. 02 (2012): 1250041. http://dx.doi.org/10.1142/s0218127412500411.

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The nonlinear stability analysis of boiling water nuclear reactors (BWRs) is conducted with the aid of so-called advanced, well validated, system codes and an advanced reduced order model to build a detailed mathematical understanding of the BWR behavior in the practical relevant parameter space. In the last years, the existence of Hopf-bifurcation points was confirmed by some researchers. In the framework of this paper, a parameter region was analyzed in which the coexistence of different stability states is realized. As a novel result, we found a parameter region in which stable fixed points

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Zohuri, Bahman. "Enhancing Nuclear Reactor Safety through ICE Digital Systems and Cyber Integration." Journal of Material Sciences & Manufacturing Research 5, no. 1 (2024): 1–6. http://dx.doi.org/10.47363/jmsmr/2024(5)164.

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This article examines the imperative of enhancing nuclear reactor safety through the Integration of Instrumentation, Control, and Electrical) Digital (ICE) Systems and cybersecurity measures. Focused on advancements within Boiling Water Reactors (BWRs), particularly the BWRX-300, the discussion emphasizes the transformative impact of digital technology on safety protocols. ICE Digital Systems contribute to real-time monitoring, predictive maintenance, and remote operation, optimizing reactor performance. Simultaneously, robust cybersecurity measures are integrated to safeguard against potentia

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Cui, Weihua, Bao Song, Chao Fu, and Hui Wang. "Effect of pitch on mechanical properties of braided wire rope under winding and traction condition." Journal of Physics: Conference Series 2355, no. 1 (2022): 012080. http://dx.doi.org/10.1088/1742-6596/2355/1/012080.

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Abstract In the tension stringing construction process of power transmission and transformation engineering, the braided wire ropes (BWRs) are in the state of winding and stretching when passing through the friction drum. Pitch is an important structural parameter of BWRs, which directly influences the mechanical behaviors under these conditions. Based on the YS9-8×19 wire rope, this project studies the effect of the rope strand pitch on the curvature and winding from both qualitative and quantitative aspects. Qualitative analysis initially explores the effect of the pitch on the mechanical be

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Mertyurek, Ugur, Riley Cumberland, and William A. Wieselquist. "Core Physics Characteristics of Extended Enrichment and High Burnup Boiling Water Reactor Fuel." Journal of Nuclear Engineering 6, no. 1 (2025): 4. https://doi.org/10.3390/jne6010004.

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This paper presents the highlights of boiling water reactor (BWR) core physics studies performed at Oak Ridge National Laboratory as part of a series of studies conducted to compare low-enriched uranium (LEU) with LEU+ fuel. The studies analyzed isotopic fuel content, lattice parameters (Phase 1), and core physics (Phase 2) to identify challenges in operation, storage, and transportation for BWRs and pressurized water reactors (PWRs). Because of a lack of publicly available lattice and core designs for modern BWR fuel assemblies and reactor cores, several optimized lattice designs were generat

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Macdonald, Digby D., and George R. Engelhardt. "A Critical Review of Radiolysis Issues in Water-Cooled Fission and Fusion Reactors: Part II, Prediction of Corrosion Damage in Operating Reactors." Corrosion and Materials Degradation 3, no. 4 (2022): 694–758. http://dx.doi.org/10.3390/cmd3040038.

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The radiolysis of water is a significant cause of corrosion damage in the primary heat transport systems (PHTSs) of water-cooled, fission nuclear power reactors (BWRs, PWRs, and CANDUs) and is projected to be a significant factor in the evolution of corrosion damage in future fusion reactors (e.g., the ITER that is currently under development). In Part I of this two-part series, we reviewed the proposed mechanisms for the radiolysis of water and demonstrate that radiolysis leads to the formation of a myriad of oxidizing and reducing species. In this Part II, we review the role that the radioly

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Harder, James W., Jing Ma, Pascale Alard та ін. "Male microbiota-associated metabolite restores macrophage efferocytosis in female lupus-prone mice via activation of PPARγ/LXR signaling pathways". Journal of Leukocyte Biology 113, № 1 (2023): 41–57. http://dx.doi.org/10.1093/jleuko/qiac002.

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Abstract Systemic lupus erythematosus development is influenced by both sex and the gut microbiota. Metabolite production is a major mechanism by which the gut microbiota influences the immune system, and we have previously found differences in the fecal metabolomic profiles of lupus-prone female and lupus-resistant male BWF1 mice. Here we determine how sex and microbiota metabolite production may interact to affect lupus. Transcriptomic analysis of female and male splenocytes showed genes that promote phagocytosis were upregulated in BWF1 male mice. Because patients with systemic lupus erythe

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Harder, James W., Jing Ma, Pascale Alard, Xiang Zhang, Fang Yuan та Michele M. Kosiewicz. "Male microbiota-associated metabolites restore macrophage efferocytosis in female lupus-prone mice via PPARγ and LXR signaling pathways". Journal of Immunology 206, № 1_Supplement (2021): 105.04. http://dx.doi.org/10.4049/jimmunol.206.supp.105.04.

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Abstract Sex and gut microbiota both influence systemic lupus erythematosus (SLE) development. We have found that male and lupus-prone female NZBxNZW F1 (BWF1) mice exhibit differences in gut microbiota and metabolomic profiles, and transfer of male microbiota suppresses disease in female mice. Here we determine how sex and microbiota may interact to affect SLE development. Transcriptomic analysis of female and male BWF1 spleens found phagocytosis-promoting genes were upregulated in males. Since defects in macrophage-mediated phagocytosis of apoptotic cells (efferocytosis) are found in SLE pat

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Teguh Sasono, Tjatur Udjianto, and Taufik Rizal. "RANCANGAN MULTISTAGE HIGH RECOVERY BRACKISH WATER REVERSE OSMOSIS PADA PLTU CILACAP KAPASITAS 660 MW." Jurnal Teknik Energi 6, no. 2 (2020): 541–46. http://dx.doi.org/10.35313/energi.v6i2.1719.

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    Rancangan sistem BWRO dengan persentase air hasil pengolahan yang tinggi (high recovery) akan mengurangi biaya operasinya. Untuk mencapai high recovery, skema multistage diterapkan dalam rancangan BWRO ini. Dengan menerapkan skema multistage dan nilai recovery per elemen sebesar 14,53%, sistem BWRO ini memiliki keandalan (reliability) yang baik dengan investasi yang rendah. Air yang diolah pada BWRO merupakan air keluaran dari Seawater Reverse Osmosis (SWRO), air keluaran SWRO ini masih mengandung mineral di dalamnya. Kandungan mineral di dalam air disebut Total Dis

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Nakagata, T., Y. Yamada, and H. Naito. "Energy expenditure, recovery oxygen consumption, and substrate oxidation during and after body weight resistance exercise with slow movement compared to treadmill walking." Physiology International 105, no. 4 (2018): 371–85. http://dx.doi.org/10.1556/2060.105.2018.4.27.

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The benefit of body weight resistance exercise with slow movement (BWRE-slow) for muscle function is well-documented, but not for energy metabolism. We aimed to examine physiological responses [e.g., energy expenditure (EE), respiratory exchange ratio (RER), and blood lactate (La)] during and after BWRE-slow compared to EE-matched treadmill walking (TW). Eight healthy young men (23.4 ± 1.8 years old, 171.2 ± 6.2 cm, 63.0 ± 4.8 kg) performed squat, push-up, lunge, heel-raise, hip-lift, and crunch exercises with BWRE-slow modality. Both the concentric and eccentric phases were set to 3 s. A tota

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Ishikawa, H., E. Kubota, H. Suzuki, and K. Saito. "The target minor H antigen for F1 cytotoxic T lymphocytes induced by Igh-congenic parental spleen cells is coded for by gene linked to H-2." Journal of Immunology 134, no. 5 (1985): 2953–59. http://dx.doi.org/10.4049/jimmunol.134.5.2953.

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Abstract Graft-vs-host reaction (GvHR) induced in (B10.BR X CWB)F1 (BWF1; H-2k/b, Ighb/b) by i.v. injection with CWB (H-2b, Ighb) spleen cells resulted in complete suppression of cytotoxic T lymphocyte (CTL) responsiveness of the F1 host spleen cells (GvHR-associated immunosuppression). In contrast, GvHR induced in BWF1 mice with CSW (H-2b, Ighj; Igh-congenic to CWB) spleen cells did not affect CTL responsiveness of the F1 host spleen cells at all. The BWF1 hosts undergoing the CSW-induced GvHR generated anti-CSW CTL in their spleens, and the subsequent culture of such BWF1 spleen cells with C

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Chhabra, Anita, Sarah Parnell, Pascale Alard, and Michele Kosiewicz. "Lupus-prone (NZBxNZW)F1 mice exhibit decreased ability to induce iTregs due to defects in both antigen presenting cells and T cells (123.1)." Journal of Immunology 188, no. 1_Supplement (2012): 123.1. http://dx.doi.org/10.4049/jimmunol.188.supp.123.1.

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Abstract Quantitative and qualitative defects in regulatory T cells (CD4+CD25+Foxp3+; Tregs) are associated with many autoimmune diseases, including systemic lupus erythematosus (SLE). SLE-prone (NZBxNZW)F1 (BWF1) mice have very low frequencies of CD4+Foxp3+ in lymphoid organs compared to non-autoimmune strains, and adoptive transfer of Tregs prevents SLE presumably by restoring the “proper” Treg:effector T cell ratios. In this study, we investigated the mechanisms that could affect Treg frequencies in BWF1 mice. There were no differences in either thymic production or peripheral proliferation

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Trigunaite, Abhishek, Ayesha Khan, Evan Der, and Trine Jorgensen. "Higher numbers of Gr1hiCD11b+ cells suppress B cell differentiation and autoantibody production in male BWF1 mice (72.7)." Journal of Immunology 188, no. 1_Supplement (2012): 72.7. http://dx.doi.org/10.4049/jimmunol.188.supp.72.7.

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Abstract (NZBxNZW) F1 (BWF1) mice spontaneously develop a lupus-like disease characterized by elevated levels of anti-nuclear autoantibodies (ANA) and systemic inflammation and with a similar female bias as observed in humans. Bone marrow (BM) chimera studies have shown intrinsic disease-driving properties of female BM cells and subsequent flow-based analyses identified significantly less Gr1hiCd11b+ myeloid cells in BWF1 female mice as compared to males. As Gr1hiCD11b+ cells have been suggested to be immunosuppressive, we hypothesized that these cells suppress B cell activation and differenti

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Rigamonti, Antonello E., Valentina Bollati, Chiara Favero, et al. "Effect of a 3-Week Multidisciplinary Body Weight Reduction Program on the Epigenetic Age Acceleration in Obese Adults." Journal of Clinical Medicine 11, no. 16 (2022): 4677. http://dx.doi.org/10.3390/jcm11164677.

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Obesity and aging share common molecular and cellular mechanisms underlying the pathophysiology of cardiovascular diseases (CVD), which occur frequently in both conditions. DNA methylation (DNAm) age, a biomarker of the epigenetic clock, has been proposed as a more accurate predictor of biological aging than chronological age. A positive difference between an individual’s chronological age and DNAm age is referred to as epigenetic age acceleration. The objective of the present study was to evaluate the effects of a 3-week in-hospital body weight reduction program (BWRP) on the epigenetic age a

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Semyachkina-Glushkovskaya, Oxana, Ivan Fedosov, Thomas Penzel, et al. "Brain Waste Removal System and Sleep: Photobiomodulation as an Innovative Strategy for Night Therapy of Brain Diseases." International Journal of Molecular Sciences 24, no. 4 (2023): 3221. http://dx.doi.org/10.3390/ijms24043221.

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Emerging evidence suggests that an important function of the sleeping brain is the removal of wastes and toxins from the central nervous system (CNS) due to the activation of the brain waste removal system (BWRS). The meningeal lymphatic vessels (MLVs) are an important part of the BWRS. A decrease in MLV function is associated with Alzheimer’s and Parkinson’s diseases, intracranial hemorrhages, brain tumors and trauma. Since the BWRS is activated during sleep, a new idea is now being actively discussed in the scientific community: night stimulation of the BWRS might be an innovative and promis

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Bdour, Ahmed N., Noor Al-Sadeq, Muna Gharaibeh, Angeles Mendoza-Sammet, Maria D. Kennedy, and Sergio G. Salinas-Rodriguez. "Techno-Economic Analysis of Selected PV-BWRO Desalination Plants in the Context of the Water–Energy Nexus for Low–Medium-Income Countries." Energies 15, no. 22 (2022): 8657. http://dx.doi.org/10.3390/en15228657.

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Jordan was late in adopting seawater and brackish water desalination as a source until the late 1990s and early 2000s. However, ongoing studies are still discussing the technical, economic, and socio-political aspects of brackish water reverse osmosis (BWRO) desalination plants. In this study, the water–energy nexus was considered, in order to highlight the main challenges facing BWRO desalination. We discuss the use of photovoltaic (PV) technology, together with BWRO desalination, as an approach to compensate for ecological, financial, and social challenges in Jordan. For this purpose, the pe

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Harder, James W., Jing Ma, Pascale Alard, Xiang Zhang, Fang Yuan, and Michele M. Kosiewicz. "Male microbiota-associated metabolites restore macrophage apoptotic cell clearance function in female lupus-prone mice." Journal of Immunology 204, no. 1_Supplement (2020): 236.2. http://dx.doi.org/10.4049/jimmunol.204.supp.236.2.

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Abstract Systemic lupus erythematosus (SLE) has been linked to microbiota dysbiosis. We have previously shown that lupus-prone female and non-lupus-prone male BWF1 mice have significantly different gut microbiota compositions and metabolomic profiles. Transferring microbiota from male into female BWF1 mice suppresses disease. This protective phenotype is androgen dependent, as microbiota from castrated male BWF1 mice (i.e., lupus-prone) fails to protect against disease. This protection could be mediated via differential metabolite production. Metabolomic analyses of female, and castrated and i

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Harder, James W., Jing Ma, Anita Chhabra, et al. "Androgens may influence lupus development via an effect on the composition and metabolic activities of intestinal microbiota in BWF1 mice." Journal of Immunology 202, no. 1_Supplement (2019): 178.18. http://dx.doi.org/10.4049/jimmunol.202.supp.178.18.

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Abstract Like many autoimmune diseases, systemic lupus erythematosus (SLE) occurs much more often in females than males in humans and spontaneous mouse models of lupus, such as NZBxNZWF1 (BWF1) mice. Castration increases disease incidence, severity, and mortality in BWF1 males, and BWF1 females are protected from disease by androgen treatment, suggesting that male sex steroids, androgens, play a protective role in lupus. Accumulating evidence suggests that microbiota dysbiosis is associated with development of autoimmune diseases, and the microbiota influences and is influenced by androgens. O

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Davison, Laura, Andrés Alberto, Lauren Liegl, Thomas Vogl, and Trine Jorgensen. "Calcium binding protein S100a9 protects male lupus-prone BWF1 mice from disease development (IRC4P.448)." Journal of Immunology 194, no. 1_Supplement (2015): 57.1. http://dx.doi.org/10.4049/jimmunol.194.supp.57.1.

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Abstract Testosterone protects from SLE pathogenesis, yet the mechanism of protection remains unknown. Using the (NZB x NZW)F1 (BWF1) mouse model of SLE, we have previously shown that immunosuppressive Gr1+CD11b+ cells are elevated in protected male BWF1 mice compared with females. Female and male Gr1+ cells use different mechanisms of suppression: reactive oxygen and nitrogen species (ROS/NOS) (female), or a secreted component independent of ROS/NOS production (male). Furthermore, female Gr1+ cells lose their capacity to suppress as the mice age. In support hereof, in vivo depletion of Gr1+ c

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Manirarora, Jean N., Michele M. Kosiewicz, Sarah A. Parnell, and Pascale Alard. "Ingestion of lactobacilli delays lupus development by stimulating APC in (NZBxNZW)F1 mice (131.35)." Journal of Immunology 178, no. 1_Supplement (2007): S244. http://dx.doi.org/10.4049/jimmunol.178.supp.131.35.

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Abstract Various defects in T cells and APC have been associated with lupus in (NZBxNZW)F1 (BWF1) mice. We and others have found that BWF1 mice exhibit lower number of CD4+CD25+ regulatory cells and impaired APC function. Lactobacilli have been shown to prevent colitis and diabetes in autoimmune-prone mice and are used to treat intestinal inflammation and allergic disease in humans. Since viruses and parasites can prevent lupus in BWF1 mice, we examined whether lactobacilli ingestion would have a similar effect. After feeding BWF1 mice with three different strains of lactobacilli, we found tha

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Dand, Hardik A., Laura M. Davison, Andres Alberto, Thomas Vogl, and Trine N. Jorgensen. "S100a9-deficiency accelerates lupus disease and renal failure in male (NZB x NZW)F1 mice." Journal of Immunology 198, no. 1_Supplement (2017): 207.3. http://dx.doi.org/10.4049/jimmunol.198.supp.207.3.

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Abstract All (NZB x NZW)F1 (BWF1) female mice develop lupus-like disease, compared to ~30% of male BWF1 mice. Our previous research described an immunosuppressive effect of Gr1hiCD11bhi cells in male BWF1 mice. Specifically, as BWF1 mice age, female Gr1hi cells lost their ability to suppress altogether, while antibody-mediated depletion of Gr1hi cells accelerated disease development in male mice only. Reverse transcriptase-PCR studies revealed upregulated S100a9 and S100a8 mRNA levels in male flow-sorted Gr1hi cells as compared to cells from female BWF1 mice and non-autoimmune stains, leading

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Pun, Ming Hong Jim. "Real-Time Caries Detection of Bitewing Radiographs Using a Mobile Phone and an Artificial Neural Network: A Pilot Study." Oral 3, no. 3 (2023): 437–49. http://dx.doi.org/10.3390/oral3030035.

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This pilot study aimed to implement and assess the performance of an experimental artificial intelligence (AI) mobile phone app in the real-time detection of caries lesions on bitewing radiographs (BWRs) with the use of a back-facing mobile phone video camera. The author trained an EfficientDet-Lite1 artificial neural network using 190 radiographic images from the Internet. The trained model was deployed on a Google Pixel 6 mobile phone and used to detect caries on ten additional Internet BWRs. The sensitivity/precision/F1 scores ranged from 0.675/0.692/0.684 to 0.575/0.719/0.639 for the aggre

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Watts, Terence, Julie Watts, and Dennis Relojo-Howell. "UNCOVERING BRAINWORKING RECURSIVE THERAPY: A COMPREHENSIVE EXAMINATION OF SUBCONSCIOUS RESPONSE MECHANISMS AND THERAPEUTIC APPLICATIONS." Problems of Psychology in the 21st Century 17, no. 1 (2023): 57–65. http://dx.doi.org/10.33225/ppc/23.17.57.

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This study provides a comprehensive examination of BrainWorking Recursive Therapy (BWRT), an innovative psychotherapeutic approach that leverages insights from neuroscience and consciousness studies. The study traces BWRT's theoretical foundations in research on neurological processes and the "cognitive gap" between stimulus and response. It outlines BWRT's evolution into a structured therapy model with demonstrated effectiveness for trauma, anxiety, depression, and other conditions. The narrative highlights BWRT's adaptability, aligning with digital mental health trends and interdisciplinary

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Chhabra, Anita, Pascale Alard, and Michele Kosiewicz. "Gut CD103+ dendritic cells from female lupus-prone (NZBxNZW) F1 (BWF1) mice are much less effective than male BWF1 mice at inducing iTregs (P4087)." Journal of Immunology 190, no. 1_Supplement (2013): 127.15. http://dx.doi.org/10.4049/jimmunol.190.supp.127.15.

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Abstract Regulatory CD4+Foxp3+ cells (Tregs) either develop in the thymus (nTregs) or are converted from non-Tregs in the periphery (iTregs). Lupus is much more prevalent in females than males, and although we have found that female BWF1 mice have lower Treg% than males and Treg% are increased in androgen-treated females and decreased in castrated males, it is unclear whether it is the nTregs or iTregs that are affected. In this study, we compared the ability of female and male BWF1 cells to mediate conversion. We found no differences in the ability of female and male BWF1 in vitro generated (

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Rigamonti, Antonello E., Gianfranco Frigerio, Diana Caroli, et al. "A Metabolomics-Based Investigation of the Effects of a Short-Term Body Weight Reduction Program in a Cohort of Adolescents with Obesity: A Prospective Interventional Clinical Study." Nutrients 15, no. 3 (2023): 529. http://dx.doi.org/10.3390/nu15030529.

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Metabolomics applied to assess the response to a body weight reduction program (BWRP) may generate valuable information concerning the biochemical mechanisms/pathways underlying the BWRP-induced cardiometabolic benefits. The aim of the present study was to establish the BWRP-induced changes in the metabolomic profile that characterizes the obese condition. In particular, a validated liquid chromatography–tandem mass spectrometry (LC–MS/MS) targeted metabolomic approach was used to determine a total of 188 endogenous metabolites in the plasma samples of a cohort of 42 adolescents with obesity (

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Ishikawa, Sho, Taku Sato, Masaaki Abe, et al. "Aberrant High Expression of B Lymphocyte Chemokine (Blc/Cxcl13) by C11b+Cd11c+ Dendritic Cells in Murine Lupus and Preferential Chemotaxis of B1 Cells towards Blc." Journal of Experimental Medicine 193, no. 12 (2001): 1393–402. http://dx.doi.org/10.1084/jem.193.12.1393.

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We observed here that the expression of B lymphocyte chemokine (BLC/CXCL13) was markedly enhanced in the thymus and kidney in aged (NZB × NZW)F1 (BWF1) mice developing lupus nephritis, but not in similarly aged NZB and NZW mice. BLC-positive cells were present in the cellular infiltrates in the target organs with a reticular pattern of staining. CD11b+CD11c+ dendritic cells were increased in the thymus and spleen in aged BWF1 mice and identified as the major cell source for BLC. CD4+ T cells as well as B cells were dramatically increased in the thymus in aged BWF1 mice, whereas no increase was

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Kosiewicz, Michele, Pascale Alard, Xiang Zhang, Thomas Fausnaught, and Anita Chhabra. "Male microbiota protects female BWF1 mice from lupus and death by restoring CD103DC function possibly via metabolite(s) production (THER5P.914)." Journal of Immunology 194, no. 1_Supplement (2015): 139.16. http://dx.doi.org/10.4049/jimmunol.194.supp.139.16.

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Abstract Alterations in microbiota composition are associated with autoimmune diseases. Little is known about the effect of microbial metabolite production on disease development. CD103 dendritic cells (CD103DC) induce regulatory T cells (iTregs) in the periphery. We have found that lupus-resistant male BWF1 mice exhibit increased disease incidence/mortality when treated with anti-CD103 antibody. Female CD103DC exhibit lower tolerogenic function than male cells in vitro and in vivo (i.e., oral tolerance) possibly due to a defect in the retinoic acid synthesis pathway. We also found that microb

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Mapari, Kaushal E., Venkat Krishnamurty, and Arga Chandrashekar Anil. "Role of Reporting in Compliance Monitoring and Enforcement of Ballast Water Management." ASEAN Journal on Science and Technology for Development 35, no. 1-2 (2018): 49–52. http://dx.doi.org/10.29037/ajstd.473.

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The Decision Support System (DSS) for ballast water management in any given port is dependent on the availability of information on ballast water carried by a ship in advance. Collation of information through Ballast Water Reporting Forms (BWRF) has been adopted by several countries. This paper provides a comparison of the reporting forms adopted by some of the countries and the International Maritime Organization (IMO) recommended BWRF. The manually submitted reporting forms have several limitations and India has developed a self-validating Electronic Ballast Water Reporting Form (e-BWRF) to

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Ma, Jing, Pascale Alard, and Michele Kosiewicz. "Deficiency in CD103DC function leading to decreased pTregs in female lupus-prone mice is due to defects in intestinal lamina propria stromal cell function that can be restored by male microbiota." Journal of Immunology 212, no. 1_Supplement (2024): 1368_5758. http://dx.doi.org/10.4049/jimmunol.212.supp.1368.5758.

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Abstract Active lupus in humans is associated with low Treg percentages, but not function. We have found that lupus-prone female BWF1 have decreased peripherally-derived Tregs (pTregs), but not function vs lupus-resistant male BWF1 mice. Gut CD103+ DC (CD103DC), the major pTreg inducer, function is decreased in female mice due to defects in the retinoic acid (RA) synthesis pathway, i.e., lower RALDH2 (critical enzyme) and higher Zfp36 expression (degrades RALDH2 RNA). Both normal CD103DC development/function and RALDH2 expression require exogenous RA. Treating female CD103DC with RA restored f

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Pearson, Jeffrey L., Peter R. Michael, Noreddine Ghaffour, and Thomas M. Missimer. "Economics and Energy Consumption of Brackish Water Reverse Osmosis Desalination: Innovations and Impacts of Feedwater Quality." Membranes 11, no. 8 (2021): 616. http://dx.doi.org/10.3390/membranes11080616.

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Brackish water desalination, using the reverse osmosis (BWRO) process, has become common in global regions, where vast reserves of brackish groundwater are found (e.g., the United States, North Africa). A literature survey and detailed analyses of several BWRO facilities in Florida have revealed some interesting and valuable information on the costs and energy use. Depending on the capacity, water quality, and additional scope items, the capital cost (CAPEX) ranges from USD 500 to USD 2947/m3 of the capacity (USD 690–USD 4067/m3 corrected for inflation to 2020). The highest number was associat

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Rigamonti, Antonello E., Federico M. Rubino, Diana Caroli, et al. "Effects of Melatonin on Exercise-Induced Oxidative Stress in Adults with Obesity Undergoing a Multidisciplinary Body Weight Reduction Program." Journal of Clinical Medicine 13, no. 17 (2024): 5216. http://dx.doi.org/10.3390/jcm13175216.

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Background: Obesity is characterized by increased oxidative stress, which, in a vicious circle, promotes chronic low-grade inflammation. Melatonin, a well-documented antioxidant, might be useful as a supplement to enhance the cardiometabolic benefits of any body weight reduction program (BWRP). Objectives/Methods: The present study aimed to evaluate the post-exercise oxidative stress and inflammation in a group of subjects with obesity treated with melatonin (2 mg/die) or placebo, undergoing a 2-week BWRP, with the administration of a single bout of acute exercise at the start and the end of t

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Mohammad, Noormohammadpour, Srivastava Ajitesh, and S. Raghavendra Cauligi. "On Minimizing the Completion Times of Long Flows Over Inter-Datacenter WAN." IEEE Communications Letters 22, no. 12 (2018): 2475–78. https://doi.org/10.1109/LCOMM.2018.2872980.

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Long flows contribute huge volumes of traffic over inter-datacenter WAN. The flow completion time (FCT) is a vital network performance metric that affects the running time of distributed applications and the users' quality of experience. Flow routing techniques based on propagation or queuing latency or instantaneous link utilization are insufficient for minimization of the long flows' FCT. We propose a routing approach that uses the remaining sizes and paths of all ongoing flows to minimize the worst-case completion time of incoming flows assuming no knowledge of future flow arrivals.

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Rigamonti, Antonello E., Valentina Bollati, Chiara Favero, et al. "Changes in DNA Methylation of Clock Genes in Obese Adolescents after a Short-Term Body Weight Reduction Program: A Possible Metabolic and Endocrine Chrono-Resynchronization." International Journal of Environmental Research and Public Health 19, no. 23 (2022): 15492. http://dx.doi.org/10.3390/ijerph192315492.

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Circadian rhythms are generated by a series of genes, collectively named clock genes, which act as a self-sustained internal 24 h timing system in the body. Many physiological processes, including metabolism and the endocrine system, are regulated by clock genes in coordination with environmental cues. Loss of the circadian rhythms has been reported to contribute to widespread obesity, particularly in the pediatric population, which is increasingly exposed to chronodisruptors in industrialized society. The aim of the present study was to evaluate the DNA methylation status of seven clock genes

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Shmueli, Aviv, Avia Fux-Noy, Esti Davidovich, Diana Ram, and Moti Moskovitz. "Comparing Images from Near-Infrared Light Reflection and Bitewing Radiography to Detect Proximal Caries in Primary Teeth." Children 11, no. 12 (2024): 1455. http://dx.doi.org/10.3390/children11121455.

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Objectives: The present prospective study aimed to compare near-infrared light reflection (NIRI) and bitewing radiographs (BWR) images to detect proximal caries in primary teeth. Methods: 71 children underwent routine BWR, and scans were performed using an intra-oral scanner (iTero Element 5D, Align Technology, Tempe, AZ, USA), including a near-infrared light source (850 nm) and sensor. Five specialist pediatric dentists examined the NIRI and BWR images. Results: The average participant age was 7.8 years. A total of 1004 proximal surfaces of primary molars and canines were examined, 209 cariou

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Tucker, Colleen F., Sarah A. Parnell, Pascale Alard, and Michele M. Kosiewicz. "Analysis of gender-based disparity in Treg populations in young lupus-prone mice (99.30)." Journal of Immunology 182, no. 1_Supplement (2009): 99.30. http://dx.doi.org/10.4049/jimmunol.182.supp.99.30.

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Abstract Females have a higher incidence of autoimmune disease than males. There is a consistently greater disparity in Foxp3+ Treg% between young females and males in autoimmune- vs non-autoimmune prone strains of mice, i.e., lupus-prone BWF1 female mice had lower Treg% than males. This disparity was not due to differences between female and male BWF1 mice in thymic production or homeostatic proliferation of Tregs in vivo, or the ability to convert Tregs in response to TGFβ, but could be due to the significantly higher rates of non-Treg CD4+ cell proliferation in vivo in female mice. These da

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Larose-Pierre, Margareth, John J. Scrivens, Daryl Norwood, and Leonard Rappa. "Necrotizing Fasciitis Caused by Group A Streptococcus: Case Report and Therapy Update." Journal of Pharmacy Practice 15, no. 3 (2002): 290–96. http://dx.doi.org/10.1106/bwr9-m77y-pqcv.

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Necrotizing fasciitis is a life-threatening infection that affects the fascia and fat tissue underlying the skin. The diagnosis is often difficult because subcutaneous changes may not be readily apparent. Toxin-producing bacteria are usually the cause, with group A streptococcus (GAS) or Streptococcus pyogenes being responsible for a significant portion of the morbidity and mortality associated with this infection. The mortality rate associated with necrotizing fasciitis varies between 30% and 60%. Toxic shock-like syndrome and multisystem organ failure are the usual causes of death. Early dia

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Choi, Hyeung-Sik, and Yong-Heon Park. "Development of a biped walking robot actuated by a closed-chain mechanism." Robotica 24, no. 1 (2005): 31–37. http://dx.doi.org/10.1017/s0263574704001237.

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We developed a new type of a human-sized BWR (biped walking robot) driven by the closed-chain type of a joint actuator. Each leg of the BWR is composed of three pitch joints and one roll joint. In all, a 12 degree-of-freedom robot, including four arm joints, was developed. The BWR was designed to walk autonomously; it is actuated by small 90W DC motors/drivers and is has DC batteries and controllers. A new type of the joint actuator for the BWR is composed of the four-bar-link mechanism driven by a ball screw which has high strength and high gear ratio despite its light weight.In this paper, a

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Litzenburger, Friederike, Katrin Heck, Dalia Kaisarly, and Karl-Heinz Kunzelmann. "Diagnostic validity of early proximal caries detection using near-infrared imaging technology on 3D range data of posterior teeth." Clinical Oral Investigations 26, no. 1 (2021): 543–53. http://dx.doi.org/10.1007/s00784-021-04032-1.

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Abstract Objectives This in vitro study analysed potential of early proximal caries detection using 3D range data of teeth consisting of near-infrared reflection images at 850 nm (NIRR). Materials and methods Two hundred fifty healthy and carious permanent human teeth were arranged pairwise, examined with bitewing radiography (BWR) and NIRR and validated with micro-computed tomography. NIRR findings were evaluated from buccal, lingual and occlusal (trilateral) views according to yes/no decisions about presence of caries. Reliability assessments included kappa statistics and revealed high agree

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Chhabra, Anita, Pascale Alard, Venkatakrishna Jala, Bodduluri Haribabu, and Michele Kosiewicz. "A role for hormones, gut microbiota and tolerogenic CD103DC in protection of male (NZBxNZW)F1 (BWF1) mice from lupus (MUC8P.805)." Journal of Immunology 192, no. 1_Supplement (2014): 198.6. http://dx.doi.org/10.4049/jimmunol.192.supp.198.6.

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Abstract Mechanisms leading to gut homeostasis affect both mucosal and systemic immune function, and involve gut microbiota. Tolerogenic dendritic cells (CD103DC) play a role in gut homeostasis, including generation of induced regulatory T cells (iTregs). Previously, we found that treatment of male BWF1 mice with anti-CD103 antibody significantly increases disease incidence/mortality. Male CD103DC exhibit significantly greater tolerogenic function than either female or castrated male CD103DC in vitro. This study examines the mechanism of sex differences in CD103DC function, and the role of mic

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Alard, Pascale, Sarah Parnell, Jean Manirarora, Michele Kosiewicz, and Safinur Atay. "Probiotics control lupus progression via induction of regulatory cells and IL-10 production (50.30)." Journal of Immunology 182, no. 1_Supplement (2009): 50.30. http://dx.doi.org/10.4049/jimmunol.182.supp.50.30.

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Abstract Microorganisms can evade the immune response via induction of regulatory cells, and can prevent the development of various autoimmune diseases. Probiotics, including Lactobacilli, are beneficial bacteria that play an important role in the immune system development. The goal of this study was to test whether gavaging (NZBxNZW)F1 (BWF1) lupus-prone mice with Lactobacilli weekly could control lupus development and identify the mechanisms mediating protection. BWF1 mice fed with Lactobacilli starting before disease onset exhibited a delay in lupus onset indicated by decreased severity and

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Chiang, Ren-Tai. "Safety Features of Advanced and Economic Simplified Boiling Water Reactors." Indonesian Journal of Physics and Nuclear Applications 3, no. 1 (2018): 1–6. http://dx.doi.org/10.24246/ijpna.v3i1.1-6.

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The Advanced Boiling Water Reactor (ABWR) and the Economic Simplified Boiling Water Reactor (ESBWR) are two kinds of contemporary, advanced, commercially available nuclear power reactors. Reactor internal pumps in an ABWR improve performance while eliminating the large recirculation pumps in earlier BWRs. The utilization of natural circulation and passive safety systems in the ESBWR design simplifies nuclear reactor system designs, reduces cost, and provides a reliable stability solution for inherently safe operation. The conceptually reliable stability solution for inherently safe ESBWR opera

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Galushin, Sergey, and Pavel Kudinov. "Analysis of the Effect of Severe Accident Scenario on Debris Properties in Lower Plenum of Nordic BWR Using Different Versions of MELCOR Code." Science and Technology of Nuclear Installations 2019 (April 17, 2019): 1–18. http://dx.doi.org/10.1155/2019/5310808.

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Nordic Boiling Water Reactors (BWRs) employ ex-vessel debris coolability as a severe accident management strategy (SAM). Core melt is released into a deep pool of water where formation of noncoolable debris bed and ex-vessel steam explosion can pose credible threats to containment integrity. Success of the strategy depends on the scenario of melt release from the vessel that determines the melt-coolant interaction phenomena. The melt release conditions are determined by the in-vessel phase of severe accident progression. Specifically, properties of debris relocated into the lower plenum have i

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Maddah, Hisham A. "Flux Optimization in Reverse Osmosis via the Solution-Diffusion Model." European Journal of Engineering Research and Science 4, no. 5 (2019): 39–44. http://dx.doi.org/10.24018/ejers.2019.4.5.1267.

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This paper suggests a new method of predicting flux values at reverse osmosis (RO) desalination plants. The study is initiated by using the solution-diffusion model that is applied to the groundwater source at Abqaiq plant (500 RO plant) at Saudi Aramco, Dhahran, Saudi Arabia in order to calculate the osmotic pressure of the treated water for Shedgum/Abqaiq groundwater. For modelling purposes, the same technique is used to determine the osmotic pressure drops at the same plant configuration and operating conditions when using seawater sources such that of Arabian Gulf and the Red Sea waters. H

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Arico, Quillan L., Zoie R. Kassis, Robert G. Maliva, Weixing Guo, W. Scott Manahan, and Thomas M. Missimer. "Changes in Pumping-Induced Groundwater Quality Used to Supply a Large-Capacity Brackish-Water Desalination Facility, Collier County, Florida: A New Aquifer Conceptual Model." Water 13, no. 14 (2021): 1951. http://dx.doi.org/10.3390/w13141951.

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Brackish-water reverse osmosis (BWRO) desalination facilities are designed to treat feedwater within a fixed range in salinity. If the salinity and ion concentrations of the feedwater rises above the maximum design concentrations, then the plant may ultimately fail. BWRO plants typically use groundwater as a feedwater source. Prior to the process design, a detailed groundwater assessment is made to characterize the source aquifer system and to develop a solute-transport model that is used to project the changes in water quality over the expected useful life of the facility. Solute transport-mo

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Maricic, Igor, Ramesh Halder, Idania Marrero, Dwight H. Kono, and Vipin Kumar. "Type II NKT cells directed immune regulatory mechanism(s) control spontaneous lupus nephritis in mice." Journal of Immunology 202, no. 1_Supplement (2019): 132.5. http://dx.doi.org/10.4049/jimmunol.202.supp.132.5.

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Abstract NKT cells recognize lipid antigens presented by CD1d molecules and can be categorized as iNKT cells and type II NKT cells. Type II NKT cells recognize sulfatide or lysophosphatidylcholine (LPC), and their activation results in cross-regulation of iNKT cells, tolerization of DC and control of inflammatory diseases. iNKT cells have been shown to play a pathogenic role in (NZB x NZW)F1 or BWF1 mice, a prototype for human SLE. Interestingly, anti-glycosphingolipid antibody responses have been found in lupus patients. Since sulfatide is enriched in kidney glomeruli, we have examined the ro

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Nuryana, Arby, and Rida Siti Nur'aini Mahmudah. "Analyzing Simplified BWR Inherent Safety System using IAEA Generic Boiling Water Reactor Simulator." Jurnal Penelitian Fisika dan Aplikasinya (JPFA) 11, no. 2 (2021): 114–26. http://dx.doi.org/10.26740/jpfa.v11n2.p114-126.

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The inherent safety of boiling water reactors (BWR) has been a vital research topic in the past decades. This study aimed to observe and analyze the simplified BWR inherent safety system incorporated in IAEA Generic BWR Simulator. This simulator represents important features of BWR and provides graphical information and real-time simulation data. The simulated BWR has 1300 MWe power with ABWR-type containment. To analyze its inherent safety system, three conditions are simulated, i.e., normal condition at 100% power, transient condition (feedwater pumps trip), and emergency condition (loss of

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Rezk, Hegazy, Basem Alamri, Mokhtar Aly, et al. "Multicriteria Decision-Making to Determine the Optimal Energy Management Strategy of Hybrid PV–Diesel Battery-Based Desalination System." Sustainability 13, no. 8 (2021): 4202. http://dx.doi.org/10.3390/su13084202.

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This paper identifies the best energy management strategy of hybrid photovoltaic–diesel battery-based water desalination systems in isolated regions using technical, economic and techno–economic criteria. The employed procedures include Criteria Importance Through Intercriteria Correlation (CRITIC) and Technique for Order Preference by Similarity to Ideal Solution (TOPSIS) as tools for the solution. Twelve alternatives, containing three–four energy management strategies; four energy management strategies, load following (LF), cycle charging (CC), combined LF–CC, and predictive strategy; and th

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