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Journal articles on the topic 'C. elegans maze'

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Published: 4 June 2021

Last updated: 1 February 2022

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1

Qin, Jianhua, and Aaron R. Wheeler. "Maze exploration and learning in C. elegans." Lab Chip 7, no. 2 (2007): 186–92. http://dx.doi.org/10.1039/b613414a.

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Lin, Haochang, Sha Wu, Zhiying Weng та ін. "Tianma Formula Alleviates Dementia via ACER2-Mediated Sphingolipid Signaling Pathway Involving Aβ". Evidence-Based Complementary and Alternative Medicine 2021 (4 серпня 2021): 1–20. http://dx.doi.org/10.1155/2021/6029237.

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Objective. To reveal the molecular mechanism of the antagonistic effect of traditional Chinese medicine Tianma formula (TF) on dementia including vascular dementia (VaD) and Alzheimer’s disease (AD) and to provide a scientific basis for the study of traditional Chinese medicine for prevention and treatment of dementia. Method. The TF was derived from the concerted application of traditional Chinese medicine. We detected the pharmacological effect of TF in VaD rats. The molecular mechanism of TF was examined by APP/PS1 mice in vivo, Caenorhabditis elegans (C. elegans) in vitro, ELISA, pathologi

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Barrios, Arantza, Stephen Nurrish, and Scott W. Emmons. "Sensory Regulation of C. elegans Male Mate-Searching Behavior." Current Biology 18, no. 23 (2008): 1865–71. http://dx.doi.org/10.1016/j.cub.2008.10.050.

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Maiti, Panchanan, Jayeeta Manna, Zoe N. Burch, Denise B. Flaherty, Joseph D. Larkin, and Gary L. Dunbar. "Ameliorative Properties of Boronic Compounds in In Vitro and In Vivo Models of Alzheimer’s Disease." International Journal of Molecular Sciences 21, no. 18 (2020): 6664. http://dx.doi.org/10.3390/ijms21186664.

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Alzheimer’s disease (AD) is characterized by amyloid (Aβ) aggregation, hyperphosphorylated tau, neuroinflammation, and severe memory deficits. Reports that certain boronic compounds can reduce amyloid accumulation and neuroinflammation prompted us to compare trans-2-phenyl-vinyl-boronic-acid-MIDA-ester (TPVA) and trans-beta-styryl-boronic-acid (TBSA) as treatments of deficits in in vitro and in vivo models of AD. We hypothesized that these compounds would reduce neuropathological deficits in cell-culture and animal models of AD. Using a dot-blot assay and cultured N2a cells, we observed that T

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Barr, Maureen M. "C. elegans male mating behavior." Seminars in Cell & Developmental Biology 33 (September 2014): 1–2. http://dx.doi.org/10.1016/j.semcdb.2014.06.006.

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Hall, David H. "The Nematode Caenorhabditis elegans A Model Animal “Made for Microscopy”." Microscopy Today 12, no. 2 (2004): 8–13. http://dx.doi.org/10.1017/s1551929500069807.

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The small unassuming nematode, Caenorhabditis elegans is only one millimeter long and lives in the soil munching on bacteria. While many nematode (roundworm) species are parasites with medical or agricultural importance, C. elegans seems to harm no one. Yet, this animal has attained a status in medical science that compares to more complex organisms such as the mouse or fruit fly in its utility for scientific discovery. It has been the subject of thousands of studies dealing with topics as diverse as nutrition, aging, and nervous system development. About 5000 scientists are now pursuing this

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Chasnov, J. R., and King L. Chow. "Why Are There Males in the Hermaphroditic Species Caenorhabditis elegans?" Genetics 160, no. 3 (2002): 983–94. http://dx.doi.org/10.1093/genetics/160.3.983.

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Abstract The free-living nematode worm Caenorhabditis elegans reproduces primarily as a self-fertilizing hermaphrodite, yet males are maintained in wild-type populations at low frequency. To determine the role of males in C. elegans, we develop a mathematical model for the genetic system of hermaphrodites that can either self-fertilize or be fertilized by males and we perform laboratory observations and experiments on both C. elegans and a related dioecious species C. remanei. We show that the mating efficiency of C. elegans is poor compared to a dioecious species and that C. elegans males are

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Schedin, P., C. P. Hunter, and W. B. Wood. "Autonomy and nonautonomy of sex determination in triploid intersex mosaics of C. elegans." Development 112, no. 3 (1991): 863–79. http://dx.doi.org/10.1242/dev.112.3.863.

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The primary sex-determining signal in Caenorhabditis elegans is the ratio of X chromosomes to sets of autosomes (X/A ratio), normally 1.0 in hermaphrodites (XX) and 0.5 in males (XO). XX triploids (X/A = 0.67) are males, but if these animals carry a partial duplication of the X chromosome such that X/A approximately equal to 0.7, they develop as intersexes that are sexually mosaic. We have analyzed these mosaics using Nomarski microscopy and in situ hybridization to obtain information on whether sex determination decisions can be made independently in different cells and tissues, and when thes

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CUTTER, ASHER D., LETICIA AVILÉS, and SAMUEL WARD. "The proximate determinants of sex ratio in C. elegans populations." Genetical Research 81, no. 2 (2003): 91–102. http://dx.doi.org/10.1017/s001667230300613x.

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The soil nematode Caenorhabditis elegans is an example of a species in which self-fertilizing hermaphrodites predominate, but functional males continue to persist – allowing outcrossing to persevere at low levels. Hermaphrodites can produce male progeny as a consequence of sex chromosome non-disjunction or via outcrossing with males. Consequently, the genetics of sex determination coupled with the efficiency by which males find, inseminate and obtain fertilizations with hermaphrodites will influence the frequency at which males and outcrossing occurs in such populations. Behavioural and physio

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Dong, Li, Matteo Cornaglia, Thomas Lehnert, and Martin A. M. Gijs. "On-chip microfluidic biocommunication assay for studying male-induced demise in C. elegans hermaphrodites." Lab on a Chip 16, no. 23 (2016): 4534–45. http://dx.doi.org/10.1039/c6lc01005a.

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Abbott, Mark, Stephen A. Banse, Ilija Melentijevic, et al. "A simplified design for the C. elegans lifespan machine." Journal of Biological Methods 7, no. 4 (2020): e137. http://dx.doi.org/10.14440/jbm.2020.332.

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Caenorhabditis elegans (C. elegans) lifespan assays constitute a broadly used approach for investigating the fundamental biology of longevity. Traditional C. elegans lifespan assays require labor-intensive microscopic monitoring of individual animals to evaluate life/death over a period of weeks, making large-scale high throughput studies impractical. The lifespan machine developed by Stroustrup et al. (2013) adapted flatbed scanner technologies to contribute a major technical advance in the efficiency of C. elegans survival assays. Introducing a platform in which large portions of a lifespan

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Drace, Kevin, and Creg Darby. "The hmsHFRS Operon of Xenorhabdus nematophila Is Required for Biofilm Attachment to Caenorhabditis elegans." Applied and Environmental Microbiology 74, no. 14 (2008): 4509–15. http://dx.doi.org/10.1128/aem.00336-08.

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ABSTRACT The bacterium Xenorhabdus nematophila is an insect pathogen and an obligate symbiont of the nematode Steinernema carpocapsae. X. nematophila makes a biofilm that adheres to the head of the model nematode Caenorhabditis elegans, a capability X. nematophila shares with the biofilms made by Yersinia pestis and Yersinia pseudotuberculosis. As in Yersinia spp., the X. nematophila biofilm requires a 4-gene operon, hmsHFRS. Also like its Yersinia counterparts, the X. nematophila biofilm is bound by the lectin wheat germ agglutinin, suggesting that β-linked N-acetyl-d-glucosamine or N-acetyln

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Noble, Luke M., Audrey S. Chang, Daniel McNelis, et al. "Natural Variation in plep-1 Causes Male-Male Copulatory Behavior in C. elegans." Current Biology 25, no. 20 (2015): 2730–37. http://dx.doi.org/10.1016/j.cub.2015.09.019.

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Haag, Eric S., and Judith Kimble. "Regulatory Elements Required for Development of Caenorhabditis elegans Hermaphrodites Are Conserved in the tra-2 Homologue of C. remanei, a Male/Female Sister Species." Genetics 155, no. 1 (2000): 105–16. http://dx.doi.org/10.1093/genetics/155.1.105.

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Abstract The Caenorhabditis elegans hermaphrodite is essentially a female that produces sperm. In C. elegans, tra-2 promotes female fates and must be repressed to achieve hermaphrodite spermatogenesis. In an effort to learn how mating systems evolve, we have cloned tra-2 from C. remanei, the closest gonochoristic relative of C. elegans. We found its structure to be similar to that of Ce-tra-2 but its sequence to be divergent. RNA interference demonstrates that Cr-tra-2 promotes female fates. Two sites of tra-2 regulation are required for the onset of hermaphrodite spermatogenesis in C. elegans

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Hodgkin, Jonathan. "Primary sex determination in the nematode C. elegans." Development 101, Supplement (1987): 5–16. http://dx.doi.org/10.1242/dev.101.supplement.5.

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Most nematodes have XO male/XX female sex determination. C. elegans is anomalous, having XX hermaphrodites rather than females. The hermaphrodite condition appears to result from the modification of a basic male/female sex-determination system, which permits both spermatogenesis and oogenesis to occur within a female soma. This modification is achieved by a germ-line-specific control acting at one step in a cascade of autosomal regulatory genes, which respond to X-chromosome dosage and direct male, female, or hermaphrodite development. Mutations of one of these genes can be used to construct a

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Emmons, Scott W. "Neural Circuits of Sexual Behavior inCaenorhabditis elegans." Annual Review of Neuroscience 41, no. 1 (2018): 349–69. http://dx.doi.org/10.1146/annurev-neuro-070815-014056.

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The recently determined connectome of the Caenorhabditis elegans adult male, together with the known connectome of the hermaphrodite, opens up the possibility for a comprehensive description of sexual dimorphism in this species and the identification and study of the neural circuits underlying sexual behaviors. The C. elegans nervous system consists of 294 neurons shared by both sexes plus neurons unique to each sex, 8 in the hermaphrodite and 91 in the male. The sex-specific neurons are well integrated within the remainder of the nervous system; in the male, 16% of the input to the shared com

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Salzer, Liesa, and Michael Witting. "Quo Vadis Caenorhabditis elegans Metabolomics—A Review of Current Methods and Applications to Explore Metabolism in the Nematode." Metabolites 11, no. 5 (2021): 284. http://dx.doi.org/10.3390/metabo11050284.

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Metabolomics and lipidomics recently gained interest in the model organism Caenorhabditis elegans (C. elegans). The fast development, easy cultivation and existing forward and reverse genetic tools make the small nematode an ideal organism for metabolic investigations in development, aging, different disease models, infection, or toxicology research. The conducted type of analysis is strongly depending on the biological question and requires different analytical approaches. Metabolomic analyses in C. elegans have been performed using nuclear magnetic resonance (NMR) spectroscopy, direct infusi

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Newman, A. P., J. G. White, and P. W. Sternberg. "Morphogenesis of the C. elegans hermaphrodite uterus." Development 122, no. 11 (1996): 3617–26. http://dx.doi.org/10.1242/dev.122.11.3617.

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We have undertaken electron micrographic reconstruction of the Caenorhabditis elegans hermaphrodite uterus and determined the correspondence between cells defined by their lineage history and differentiated cell types. In this organ, many cells do not move during morphogenesis and the cell lineage may function to put cells where they are needed. Differentiated uterine cell types include the toroidal ut cells that make structural epithelium, and specialized utse and uv cells that make the connection between the uterus and the vulva. A cell fate decision in which the anchor cell (AC) induces adj

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Ghaemi, Reza, Justin Tong, Bhagwati P. Gupta, and P. Ravi Selvaganapathy. "Microfluidic Device for Microinjection of Caenorhabditis elegans." Micromachines 11, no. 3 (2020): 295. http://dx.doi.org/10.3390/mi11030295.

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Microinjection is an established and reliable method to deliver transgenic constructs and other reagents to specific locations in C. elegans worms. Specifically, microinjection of a desired DNA construct into the distal gonad is the most widely used method to generate germ-line transformation of C. elegans. Although, current C. elegans microinjection method is effective to produce transgenic worms, it requires expensive multi degree of freedom (DOF) micromanipulator, careful injection alignment procedure and skilled operator, all of which make it slow and not suitable for scaling to high throu

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Ewald, Collin Yvès, Jorge Iván Castillo-Quan, and T. Keith Blackwell. "Untangling Longevity, Dauer, and Healthspan in Caenorhabditis elegans Insulin/IGF-1-Signalling." Gerontology 64, no. 1 (2017): 96–104. http://dx.doi.org/10.1159/000480504.

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The groundbreaking discovery that lower levels of insulin/IGF-1 signaling (IIS) can induce lifespan extension was reported 24 years ago in the nematode Caenorhabditis elegans. In this organism, mutations in the insulin/IGF-1 receptor gene daf-2 or other genes in this pathway can double lifespan. Subsequent work has revealed that reduced IIS (rIIS) extends lifespan across diverse species, possibly including humans. In C. elegans, IIS also regulates development into the diapause state known as dauer, a quiescent larval form that enables C. elegans to endure harsh environments through morphologic

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Lints, R., L. Jia, K. Kim, C. Li, and S. W. Emmons. "Axial patterning of C. elegans male sensilla identities by selector genes." Developmental Biology 269, no. 1 (2004): 137–51. http://dx.doi.org/10.1016/j.ydbio.2004.01.021.

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Chan, W. H., S. Y. Yip, A. W. Cheng, and K. L. Chow. "A transcriptional network controlling male sensory organ development in C. elegans." Developmental Biology 295, no. 1 (2006): 457–58. http://dx.doi.org/10.1016/j.ydbio.2006.04.409.

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Morgan, Dyan E., Sarah L. Crittenden, and Judith Kimble. "The C. elegans adult male germline: Stem cells and sexual dimorphism." Developmental Biology 346, no. 2 (2010): 204–14. http://dx.doi.org/10.1016/j.ydbio.2010.07.022.

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Emmons, Scott W. "The mind of a male worm¯development of the C. elegans male nervous system." Developmental Biology 306, no. 1 (2007): 316–17. http://dx.doi.org/10.1016/j.ydbio.2007.03.122.

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Chen, Pei-Jiun, Soochin Cho, Suk-Won Jin, and Ronald E. Ellis. "Specification of Germ Cell Fates by FOG-3 Has Been Conserved During Nematode Evolution." Genetics 158, no. 4 (2001): 1513–25. http://dx.doi.org/10.1093/genetics/158.4.1513.

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Abstract Rapid changes in sexual traits are ubiquitous in evolution. To analyze this phenomenon, we are studying species of the genus Caenorhabditis. These animals use one of two different mating systems—male/hermaphroditic, like the model organism Caenorhabditis elegans, or male/female, like C. remanei. Since hermaphrodites are essentially females that produce sperm for self-fertilization, elucidating the control of cell fate in the germ line in each species could provide the key to understanding how these mating systems evolved. In C. elegans, FOG-3 is required to specify that germ cells bec

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Chamberlin, H. M., and J. H. Thomas. "The bromodomain protein LIN-49 and trithorax-related protein LIN-59 affect development and gene expression in Caenorhabditis elegans." Development 127, no. 4 (2000): 713–23. http://dx.doi.org/10.1242/dev.127.4.713.

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We have molecularly characterized the lin-49 and lin-59 genes in C. elegans, and found their products are related to Drosophila trithorax group (trx-G) proteins and other proteins implicated in chromatin remodelling. LIN-49 is structurally most similar to the human bromodomain protein BR140, and LIN-59 is most similar to the Drosophila trx-G protein ASH1. In C. elegans, lin-49 and lin-59 are required for the normal development of the mating structures of the adult male tail, for the normal morphology and function of hindgut (rectum) cells in both males and hermaphrodites and for the maintenanc

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Darby, Creg, Sandya L. Ananth, Li Tan, and B. Joseph Hinnebusch. "Identification of gmhA, a Yersinia pestis Gene Required for Flea Blockage, by Using a Caenorhabditis elegans Biofilm System." Infection and Immunity 73, no. 11 (2005): 7236–42. http://dx.doi.org/10.1128/iai.73.11.7236-7242.2005.

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ABSTRACT Yersinia pestis, the cause of bubonic plague, blocks feeding by its vector, the flea. Recent evidence indicates that blockage is mediated by an in vivo biofilm. Y. pestis and the closely related Yersinia pseudotuberculosis also make biofilms on the cuticle of the nematode Caenorhabditis elegans, which block this laboratory animal's feeding. Random screening of Y. pseudotuberculosis transposon insertion mutants with a C. elegans biofilm assay identified gmhA as a gene required for normal biofilms. gmhA encodes phosphoheptose isomerase, an enzyme required for synthesis of heptose, a con

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Midkiff, Daniel, and Adriana San-Miguel. "Microfluidic Technologies for High Throughput Screening Through Sorting and On-Chip Culture of C. elegans." Molecules 24, no. 23 (2019): 4292. http://dx.doi.org/10.3390/molecules24234292.

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The nematode Caenorhabditis elegans is a powerful model organism that has been widely used to study molecular biology, cell development, neurobiology, and aging. Despite their use for the past several decades, the conventional techniques for growth, imaging, and behavioral analysis of C. elegans can be cumbersome, and acquiring large data sets in a high-throughput manner can be challenging. Developments in microfluidic “lab-on-a-chip” technologies have improved studies of C. elegans by increasing experimental control and throughput. Microfluidic features such as on-chip control layers, immobil

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Inoue, Hideki, and Eisuke Nishida. "The DM Domain Transcription Factor MAB-3 Regulates Male Hypersensitivity to Oxidative Stress in Caenorhabditis elegans." Molecular and Cellular Biology 30, no. 14 (2010): 3453–59. http://dx.doi.org/10.1128/mcb.01459-09.

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ABSTRACT Sex differences occur in most species and involve a variety of biological characteristics. The nematode Caenorhabditis elegans consists of two sexes, self-fertile hermaphrodites (XX) and males (XO). Males differ from hermaphrodites in morphology, behavior, and life span. Here, we find that male C. elegans worms are much more sensitive than hermaphrodites to oxidative stress and show that the DM domain transcription factor MAB-3 plays a pivotal role in determining this male hypersensitivity. The hypersensitivity to oxidative stress does not depend on the dosage of X chromosomes but is

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Anholt, Bradley R., Christoph Vorburger, and Peter Knaus. "Mark-recapture estimates of daily survival rates of two damselflies (Coenagrion puella and Ischnura elegans)." Canadian Journal of Zoology 79, no. 5 (2001): 895–99. http://dx.doi.org/10.1139/z01-053.

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Male-biased operational sex ratios are very common in sexually mature dragonflies. These may be due to differential survival or differences in time spent at the breeding site by the sexes. Because most studies are carried out at the breeding site, these two processes can be measured as survival rates or recapture rates using modern capturemarkrecapture methods. We marked 66 female and 233 male Coenagrion puella, and 137 female and 347 male Ischnura elegans during three capture periods spread over 18 days. Each time an animal was recaptured it was re-marked so that the capture history of any

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García, L. René. "Regulation of sensory motor circuits used in C. elegans male intromission behavior." Seminars in Cell & Developmental Biology 33 (September 2014): 42–49. http://dx.doi.org/10.1016/j.semcdb.2014.05.006.

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Guo, Xiaoyan, Andrew Navetta, Daisy G. Gualberto, and L. Rene García. "Behavioral decay in aging male C. elegans correlates with increased cell excitability." Neurobiology of Aging 33, no. 7 (2012): 1483.e5–1483.e23. http://dx.doi.org/10.1016/j.neurobiolaging.2011.12.016.

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Reiner, DJ, and JH Thomas. "Reversal of a muscle response to GABA during C. elegans male development." Journal of Neuroscience 15, no. 9 (1995): 6094–102. http://dx.doi.org/10.1523/jneurosci.15-09-06094.1995.

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Aprison, Erin Z., and Ilya Ruvinsky. "Sexually Antagonistic Male Signals Manipulate Germline and Soma of C. elegans Hermaphrodites." Current Biology 26, no. 20 (2016): 2827–33. http://dx.doi.org/10.1016/j.cub.2016.08.024.

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McLellan, Jessica, Nigel O'Neil, Sanja Tarailo, et al. "Synthetic Lethal Genetic Interactions That Decrease Somatic Cell Proliferation in Caenorhabditis elegans Identify the Alternative RFCCTF18 as a Candidate Cancer Drug Target." Molecular Biology of the Cell 20, no. 24 (2009): 5306–13. http://dx.doi.org/10.1091/mbc.e09-08-0699.

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Somatic mutations causing chromosome instability (CIN) in tumors can be exploited for selective killing of cancer cells by knockdown of second-site genes causing synthetic lethality. We tested and statistically validated synthetic lethal (SL) interactions between mutations in six Saccharomyces cerevisiae CIN genes orthologous to genes mutated in colon tumors and five additional CIN genes. To identify which SL interactions are conserved in higher organisms and represent potential chemotherapeutic targets, we developed an assay system in Caenorhabditis elegans to test genetic interactions causin

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Flavell, Steven W., David M. Raizen, and Young-Jai You. "Behavioral States." Genetics 216, no. 2 (2020): 315–32. http://dx.doi.org/10.1534/genetics.120.303539.

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Caenorhabditis elegans’ behavioral states, like those of other animals, are shaped by its immediate environment, its past experiences, and by internal factors. We here review the literature on C. elegans behavioral states and their regulation. We discuss dwelling and roaming, local and global search, mate finding, sleep, and the interaction between internal metabolic states and behavior.

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Vayndorf, Elena, Jason Pitt, Judy Wu, et al. "A robotic system for high-throughput automated lifespan and phenotyping analysis in C. elegans." Innovation in Aging 4, Supplement_1 (2020): 886. http://dx.doi.org/10.1093/geroni/igaa057.3270.

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Abstract A goal of gerontology-related research is to develop therapies to improve the healthy period of life by understanding and targeting the molecular hallmarks of biological aging. Much progress has been made toward understanding the genetic and biochemical nature of these hallmarks through studies using simple invertebrate model organisms, such as the nematode Caenorhabditis elegans. Over the past decade, the identification of potential genetic and pharmacological modifiers of lifespan and age-related pathologies in C. elegans and other model organisms has yielded fruitful leads for foll

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Saifee, Owais, Laura B. Metz, Michael L. Nonet, and C. Michael Crowder. "A Gain-of-function Mutation in Adenylate Cyclase Confers Isoflurane Resistance in Caenorhabditis elegans." Anesthesiology 115, no. 6 (2011): 1162–71. http://dx.doi.org/10.1097/aln.0b013e318239355d.

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Background Volatile general anesthetics inhibit neurotransmitter release by a mechanism not fully understood. Genetic evidence in Caenorhabditis elegans has shown that a major mechanism of action of volatile anesthetics acting at clinical concentrations in this animal is presynaptic inhibition of neurotransmission. To define additional components of this presynaptic volatile anesthetic mechanism, C. elegans mutants isolated as phenotypic suppressors of a mutation in syntaxin, an essential component of the neurotransmitter release machinery, were screened for anesthetic sensitivity phenotypes.

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Egorova, Anastasia, Alsu Gatiyatullina, Dmitriy Terenzhev, Timur Belov, and Tatiana Kalinnikova. "Toxic action of substances from male fern Dryopteris filix-mas (L.) Schott (1834) on free-living soil nematode Caenorhabditis elegans Maupas (1900)." E3S Web of Conferences 254 (2021): 09011. http://dx.doi.org/10.1051/e3sconf/202125409011.

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The study of biological activity of extracts from roots and rhizomes of male fern Dryopteris filix-mas was carried out in experiments with soil nematode Caenorhabditis elegans. The toxicity of extracts of D. filix-mas roots and rhizomes obtained by different methods varied over a wide range. Crude extract of male fern roots and rhizomes in concentration range 62.5–250 µg/ml had a weak toxic action on C. elegans organism by inducing death of 26.0–43.3% nematodes. The toxicity of relatively high concentrations (500 and 250 µg/ml) of water-ethanolic extracts might be compared with such of crude e

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Krajacic, Predrag, Jane Hermanowski, Olga Lozynska, Tejvir S. Khurana, and Todd Lamitina. "C. elegans dysferlin homolog fer-1 is expressed in muscle, and fer-1 mutations initiate altered gene expression of muscle enriched genes." Physiological Genomics 40, no. 1 (2009): 8–14. http://dx.doi.org/10.1152/physiolgenomics.00106.2009.

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Mutations in the human dysferlin gene cause Limb Girdle Muscular Dystrophy 2B (LGMD2B). The Caenorhabditis elegans dysferlin homolog, fer-1, affects sperms development but is not known to be expressed in or have a functional roles outside of the male germline. Using several approaches, we show that fer-1 mRNA is present in C. elegans muscle cells but is absent from neurons. In mammals, loss of muscle-expressed dysferlin causes transcriptional deregulation of muscle expressed genes. To determine if similar alterations in gene expression are initiated in C. elegans due to loss of muscle-expresse

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Dillon, J., N. A. Hopper, L. Holden-Dye, and V. O'Connor. "Molecular characterization of the metabotropic glutamate receptor family in Caenorhabditis elegans." Biochemical Society Transactions 34, no. 5 (2006): 942–48. http://dx.doi.org/10.1042/bst0340942.

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mGluRs (metabotropic glutamate receptors) are G-protein-coupled receptors that play an important neuromodulatory role in the brain. Glutamatergic transmission itself plays a fundamental role in the simple nervous system of the model organism Caenorhabditis elegans, but little is known about the contribution made by mGluR signalling. The sequenced genome of C. elegans predicts three distinct genes, mgl-1, mgl-2 and mgl-3 (designated Y4C6A.2). We have used in silico and cDNA analyses to investigate the genes encoding mgls. Our results indicate that mgl genes constitute a gene family made up of t

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Yu, Hui, Adeline Seah, Michael A. Herman, Edwin L. Ferguson, H. Robert Horvitz, and Paul W. Sternberg. "Wnt and EGF pathways act together to induce C. elegans male hook development." Developmental Biology 327, no. 2 (2009): 419–32. http://dx.doi.org/10.1016/j.ydbio.2008.12.023.

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Stoyanov, Charles-Nicolas, Martin Fleischmann, Yo Suzuki, et al. "Expression of the C. elegans labial orthologue ceh-13 during male tail morphogenesis." Developmental Biology 259, no. 1 (2003): 137–49. http://dx.doi.org/10.1016/s0012-1606(03)00138-6.

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Chang, W. "A forkhead protein controls sexual identity of the C. elegans male somatic gonad." Development 131, no. 6 (2004): 1425–36. http://dx.doi.org/10.1242/dev.01012.

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Baylis, H. A., and K. Goyal. "TRPM channel function in Caenorhabditis elegans." Biochemical Society Transactions 35, no. 1 (2007): 129–32. http://dx.doi.org/10.1042/bst0350129.

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The nematode Caenorhabditis elegans contains over 20 genes for TRP (transient receptor potential) channels which include members of all of the subclasses identified in mammalian cells. These proteins include three members of the TRPM (TRP melastatin) family: gon-2 (abnormal gonad development), gtl-1 (gon-2-like 1) and gtl-2. Although studies of these genes are at an early stage, we are beginning to understand their functions in the life of C. elegans. Mutations in gon-2 have defective gonad formation because of failures in the cell division of the somatic gonad precursor cells. gon-2 and gtl-1

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Yeh, Shu-Dan, Ayush Shekhar Saxena, Timothy A. Crombie, et al. "The mutational decay of male-male and hermaphrodite-hermaphrodite competitive fitness in the androdioecious nematode C. elegans." Heredity 120, no. 1 (2017): 1–12. http://dx.doi.org/10.1038/s41437-017-0003-8.

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Gurvitz, Aner, Sigrid Langer, Martin Piskacek, Barbara Hamilton, Helmut Ruis та Andreas Hartig. "Predicting the Function and Subcellular Location of Caenorhabditis elegans Proteins Similar to Saccharomyces cerevisiae β-Oxidation Enzymes". Yeast 1, № 3 (2000): 188–200. http://dx.doi.org/10.1155/2000/596562.

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The role of peroxisomal processes in the maintenance of neurons has not been thoroughly investigated. We propose using Caenorhabditis elegans as a model organism for studying the molecular basis underlying neurodegeneration in certain human peroxisomal disorders, e.g. Zellweger syndrome, since the nematode neural network is well characterized and relatively simple in function. Here we have identified C. elegans PEX-5 (C34C6.6) representing the receptor for peroxisomal targeting signal type 1 (PTS1), defective in patients with such disorders. PEX-5 interacted strongly in a two-hybrid assay with

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Liu, Jing, Phoebe Tzou, Russell J. Hill, and Paul W. Sternberg. "Structural Requirements for the Tissue-Specific and Tissue-General Functions of the Caenorhabditis elegans Epidermal Growth Factor LIN-3." Genetics 153, no. 3 (1999): 1257–69. http://dx.doi.org/10.1093/genetics/153.3.1257.

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Abstract Caenorhabditis elegans lin-3 encodes a homolog of the epidermal growth factor (EGF) family of growth factors. LIN-3 is the inductive signal for hermaphrodite vulval differentiation, and it is required for animal viability, hermaphrodite fertility, and the specification of anterior cell fates in the male B cell lineage. We describe the cloning of a lin-3 homolog from C. briggsae, sequence comparison of C. elegans lin-3 with C. briggsae lin-3, and the determination of molecular lesions in alleles of C. elegans lin-3, including three new alleles. We also analyzed the severity of phenotyp

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Ahn, Il-Young, and Carlos E. Winter. "The genome of Oscheius tipulae: determination of size, complexity, and structure by DNA reassociation using fluorescent dye." Genome 49, no. 8 (2006): 1007–15. http://dx.doi.org/10.1139/g06-045.

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This work describes the physicochemical characterization of the genome and telomere structure from the nematode Oscheius tipulae CEW1. Oscheius tipulae is a free-living nematode belonging to the family Rhabditidae and has been used as a model system for comparative genetic studies. A new protocol that combines fluorescent detection of double-stranded DNA and S1 nuclease was used to determine the genome size of O. tipulae as 100.8 Mb (approximately 0.1 pg DNA/haploid nucleus). The genome of this nematode is made up of 83.4% unique copy sequences, 9.4% intermediate repetitive sequences, and 7.2%

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Moulder, G. L., M. M. Huang, R. H. Waterston, and R. J. Barstead. "Talin requires beta-integrin, but not vinculin, for its assembly into focal adhesion-like structures in the nematode Caenorhabditis elegans." Molecular Biology of the Cell 7, no. 8 (1996): 1181–93. http://dx.doi.org/10.1091/mbc.7.8.1181.

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In cultured cells, the 230-kDa protein talin is found at discrete plasma membrane foci known as focal adhesions, sites that anchor the intracellular actin cytoskeleton to the extracellular matrix. The regulated assembly of focal adhesions influences the direction of cell migrations or the reorientation of cell shapes. Biochemical studies of talin have shown that it binds to the proteins integrin, vinculin, and actin in vitro. To understand the function of talin in vivo and to correlate its in vitro and in vivo biochemical properties, various genetic approaches have been adopted. With the inten

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