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Dissertations / Theses on the topic 'C-lectins'

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Published: 4 June 2025
Last updated: 1 August 2025

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1

Didak, Blanka. "Synthèse de néoglycoconjugués et dendrimères glycomimétiques utilisés pour le développement de puces à lectines de type C et leur validation." Thesis, Université Grenoble Alpes (ComUE), 2018. http://www.theses.fr/2018GREAV036.

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Les lectines de type-C (CLR) sont des protéines de liaison au glycane qui reconnaissent les sucres de manière dépendante du Ca2+. Ils ont des rôles divers dans l'organisme humain. Ils sont responsables des interactions et de l'internalisation d'agents pathogènes tels que Candida albicans, Mycobacterium tuberculosis, le VIH ou le virus Ebola. Ils sont également impliqués dans le développement ou la prévention du cancer par la reconnaissance de glycanes spécifiques exprimés à la surface des cellules tumorales.L'importance cruciale est de trouver des ligands pour les CLR qui induiront une réponse
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2

Bouyain, Samuel. "Binding of fucosylated and anionic glycans to C-type animal lectins." Thesis, University of Oxford, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.393429.

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3

Kerscher, Berhard Gerhard Richard. "Characterisation of the C-type lectin receptor Clecsf8." Thesis, University of Aberdeen, 2016. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=230779.

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C-type lectin-like receptors (CTLRs) play critical roles in immunity and homeostasis by recognising a variety of microbial or endogenous ligands. Clecsf8 is a member of the Dectin-2 family of CTLRs. Clecsf8 shares important similarities with its relatives Mincle and Dectin-2, such as the lack of an integral signalling motif and a single, calcium dependent ligand binding domain. They were shown to associate with the FcRγ adaptor, which is essential for receptor surface expression and downstream signalling. Recent publications revealed an important role for Clecsf8 in anti-mycobacterial immunity
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4

Zelensky, Alex N. "In silico analysis of C-type lectin domains' structure and properties /." View thesis entry in Australian Digital Theses Program, 2004. http://thesis.anu.edu.au/public/adt-ANU20050318.185314/index.html.

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Thesis (Ph.D.)--Australian National University, 2004.<br>"This CD contains the software (mostly written in Perl) used for comparative structure analysis reported in Chapter 4 (str_comp directory), and for the CTLD database system described in Chapter 2 (CTLD_DB directory)."
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5

Goti, G. "GLYCOMIMETIC ANTAGONISTS OF C-TYPE LECTINS: IMPROVING LIGAND POTENCY AND MULTIVALENT PRESENTATION." Doctoral thesis, Università degli Studi di Milano, 2017. http://hdl.handle.net/2434/483585.

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Le lectine di tipo C sono recettori calcio dipendenti in grado di riconoscere in modo selettivo e di legarsi a carboidrati esposti da patogeni e cellule danneggiate, agendo quindi come un’importante meccanismo di prima difesa. Tuttavia, lectine di tipo C possono essere responsabili della patogenesi di infezioni e malattie infiammatorie, costituendo così un promettente bersaglio terapeutico. Le interazioni proteina-carboidrato sono generalmente deboli, con costanti di dissociazione nell’ordine del millimolare. Tale problema di bassa ffinità è stato risolto in Natura ricorrendo alla multivale
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6

Freitas, Alcides Alves de. "Detec??o de prote?nas em Plectranthus barbatus e avalia??o da atividade biol?gica sobre linhagens de c?lulas RAW 264.7 e A549." UFVJM, 2017. http://acervo.ufvjm.edu.br/jspui/handle/1/1674.

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Submitted by Raniere Barreto (raniere.barros@ufvjm.edu.br) on 2018-05-10T17:58:30Z No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) alcides_alves_freitas.pdf: 1707403 bytes, checksum: f9233629066db73fd877b2885aa875bd (MD5)<br>Approved for entry into archive by Rodrigo Martins Cruz (rodrigo.cruz@ufvjm.edu.br) on 2018-05-14T14:47:32Z (GMT) No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) alcides_alves_freitas.pdf: 1707403 bytes, checksum: f9233629066db73fd877b2885aa875bd (MD5)<br>Made available in DSpace o
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7

Raziunaite, Ingrida. "Use of C-type lectin receptor probes and human monoclonal antibodies to map the dynamics of the fungal cell wall." Thesis, University of Aberdeen, 2018. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=238675.

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8

Martin, Nicole C. Couillard Nicole. "Differential dengue tropism & neutralization : potential mechanisms of pathogenesis /." Download the dissertation in PDF, 2006. http://www.lrc.usuhs.mil/dissertations/pdf/Martin2006.pdf.

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9

Ishizuka, Edson Kiyotaka. "Modulação da função de macrófagos pela nattectina: uma lectina tipo C do veneno de Thalassophryne nattereri." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/42/42133/tde-26012012-093519/.

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A Nattectina é uma toxina isolada do veneno de Thalassophryne nattereri que possui homologia com lectinas tipo C. Este estudo consistiu em avaliar a ação da Nattectina sobre as funções de macrófagos e a influência de citocinas Th1/Th2 nessa ativação. Nossos resultados mostram que a Nattectina induziu o aumento da expressão de moléculas coestimuladoras dependente da sinalização MAPK p38 e PI3K em macrófagos derivados da medula óssea, e também um aumento na capacidade endocítica e expressão de MHC de classe II dependentes da sinalização ERK1/2 e da ligação da Nattectina ao carboidrato. Verificam
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10

Spearman, Catherine Wendy Nest. "The effect of two novel C-type lectins, Ba100 and Ba25, isolated from the venom of the puff adder, Bitis arietans on T lymphocyte proliferative responses." Doctoral thesis, University of Cape Town, 2008. http://hdl.handle.net/11427/3469.

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11

Kielczewska, Agnieszka. "Natural killer cell receptors and their MHC ligand interactions in innate resistance to mouse cytomegalovirus." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111896.

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Le premier but de mon projet de doctorat a ete la caracterisation moleculaire de l'interface entre les recepteurs activateurs des cellules Natural Killer (NK) et de leurs ligands exprimes dans les cellules infectees ainsi que l'implication de cette interaction sur la reponse a l'infection par le cytomegalovirus (MCMV).<br>J'ai tire un avantage de la variation naturelle au sein des membres lies aux recepteurs Ly49C ainsi que de la disponibilite des structures cristallines des Ly49 afin de comprendre les determinants moleculaires des interactions Ly49H-m157 et egalement identifier les residus de
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12

Barbosa, Paulo SÃrgio Ferreira. "Efeitos renais de miotoxinas e lectinas purificadas dos venenos das serpentes Bothrops jararacussu e Bothrops moojeni. Papel da ciclooxigenase e endotelina." Universidade Federal do CearÃ, 2006. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=555.

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CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superior<br>A insuficiÃncia renal aguda à uma das complicaÃÃes mais freqÃentes nos envenenamentos ofÃdicos. Contudo, a sua patogÃnese permanece obscura. Em nossos estudos foram avaliados os efeitos renais causados pelas miotoxinas purificadas dos venenos das serpentes Bothrops jararacussu (Bthtx I, Lys 49 e Bthtx II, Asp 49) e Bothrops moojeni (BmTx I, Lys 49), assim como pelas lectinas dos venenos de Bothrops moojeni (BmLec) e Bothrops jararacussu (BJcuL). Tentando avaliar o mecanismo envolvido nos efeitos renais das substÃncias acima mencion
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13

Achilli, Silvia. "Production recombinante de récepteurs lectines de type C et identification de ligands sélectif : de nouveaux outils pour la modulation du système immunitaire." Thesis, Université Grenoble Alpes (ComUE), 2018. http://www.theses.fr/2018GREAV014/document.

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Les lectines de type C (CLRs) sont des récepteurs impliqués dans la reconnaissance d’oligosaccharides et principalement exprimés à la surface des cellules présentatrices d’antigène (APCs) et notamment des cellules dendritiques (DCs), véritable sentinelle de notre système immunitaire. Elles sont impliquées dans la reconnaissance de motifs spécifiques exprimés à la surface d’agents pathogènes et sont capables de stimuler le système immunitaire afin de déclencher une réponse adaptée. Ce rôle crucial joué par les CLRs dans l’équilibre de la réponse immunitaire confère aux interactions CLR/glycane
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14

Troegeler, Anthony. "Analyse de la fonction de deux nouvelles lectines de type C, DCIR et CL-LK, dans l'immunité anti-tuberculeuse." Thesis, Toulouse 3, 2016. http://www.theses.fr/2016TOU30116/document.

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La tuberculose (TB) est une maladie très répandue qui provoque la mort de plus d'un million de personnes dans le monde chaque année. Cela représente un véritable problème de santé publique qui nécessite le développement de nouveaux médicaments et traitements afin de mieux lutter contre cette maladie destructrice. Dans ce contexte, il est important de comprendre la relation entre l'agent étiologique, Mycobacterium tuberculosis (Mtb) et le système immunitaire. Les mycobactéries sont recouvertes de structure glycolipidiques qui pourraient être reconnus par des récepteur spécifiques appelés lectin
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15

Andersson, Katja. "Intercellular protein transfer and regulation of inhibitory NK cell receptor accessibility /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-183-8/.

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16

Legge, Glen Barry. "Structural studies of a C-type lectin." Thesis, University of Cambridge, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.627613.

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17

Bruneau, Alexandre. "Développement de nouvelles réactions métallo-catalysées pour la création de liaisons C-C et C-hétéroatomes : Application à la synthèse d’inhibiteurs de la Hsp90 et aux ligands de la lectine A." Thesis, Université Paris-Saclay (ComUE), 2015. http://www.theses.fr/2015SACLS138.

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Les travaux rapportés dans ce mémoire concernent le développement de nouvelles réactions métallo-catalysées pour la création de liaison carbone-hétéroatome et carbone-carbone ainsi que leurs applications à la synthèse de produits biologiquement actifs. La première partie de ce manuscrit est consacrée à l'étude de la réactivité des sucres dans les couplages organométalliques. Des conditions ont été développées pour la création de la liaison C-S entre glycosyl thiols et partenaires arylés. De plus, la création de la liaison carbone azote de glycosyl amines avec des acides boroniques a été étudié
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18

Porkolab, Vanessa. "Développement de ligands multivalents de nature glycomimétiques dirigés contre les récepteurs lectines de type-C." Thesis, Université Grenoble Alpes (ComUE), 2016. http://www.theses.fr/2016GREAV013/document.

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Les composantes innée et acquise de l'immunité travaillent ensemble pour assurer une protection efficace de l'organisme. Les cellules dendritiques, cellules sentinelles de l’immunité capturent via des récepteurs de surface les agents pathogènes et les présentent aux lymphocytes T pour stimuler les réponses immunitaires adaptatives spécifiques. Une famille de ces récepteurs, nommée Récepteurs Lectines de type C (CLRs) ont un rôle important dans la reconnaissance de motifs oligosaccharides des pathogènes. Leurs fonctions sont parfois détournées par certains pathogènes à leur avantage et notammen
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19

Christou, Charita. "C-type lectin-like receptors and their interactions." Thesis, University of Oxford, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.509908.

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20

MEDVE, LAURA ANETT. "SYNTHESIS OF SELECTIVE C-TYPE LECTIN ANTAGONIST GLYCOMIMETICS." Doctoral thesis, Università degli Studi di Milano, 2018. http://hdl.handle.net/2434/584203.

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In this thesis we have tackled the problem of identifying high-affinity, selective CLR ligands with two different approaches: in the first approach, we synthesized a diversity library and screened it in microarray format against a group of human CLRs; in the second approach we proceeded to the computer-aided design of a high affinity ligand for the dendritic cell CLR DC-SIGN. In the first approach, we prepared a mannosylated (based on the structure of Manalpha1-2Man) and fucosylated glycomimetic library that was printed on microarray chips. We optimized and validated the proper presentatio
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21

Poget, Sébastien François. "Functional and structural studies of C-type lectin domains." Thesis, University of Cambridge, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.621079.

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22

Graham, Lisa Maria. "The functional characterisation of the C-type lectin : Clecsf8." Doctoral thesis, University of Cape Town, 2011. http://hdl.handle.net/11427/13438.

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Includes bibliographical references (leaves 147-157).<br>Clecsf8 is a poorly characterised member of the "Dectin-2 cluster" and was originally thought to be expressed exclusively by macrophages. In this study it was demonstrated that Clecsf8 is primarily expressed by peripheral blood neutrophils and monocytes.
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23

Salvage-Jones, Judith. "The Macrophage Inducible C-type Lectin (Mincle) is a Receptor for the Yeast, Candida Albicans." Thesis, Griffith University, 2017. http://hdl.handle.net/10072/367510.

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The Macrophage-Inducible C-type Lectin (Mincle) belongs to the family of C-type lectin receptors some of which have been well characterised. We investigated a role for Mincle in response to systemic candidiasis both in vivo and ex vivo. Our results show that while Mincle recognises C. albicans it is not phagocytic or candicidal. It does however, recognise this yeast as measured by reduced TNF-α production in Mincle deficient bone marrow-derived macrophages. Furthermore, there was a significant reduction in the cytokines KC, IL-1β, IL-10, IL-13, GCS-F, MIP-1β and RANTES in these cells. By using
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24

East, Lucy. "Functional characterisation of Endo180, a novel transmembrane C-type lectin." Thesis, Institute of Cancer Research (University Of London), 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.405017.

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25

Nassanian, Hoorig. "The biology of the C-Type lectin receptor DC-SIGN." Diss., Restricted to subscribing institutions, 2008. http://proquest.umi.com/pqdweb?did=1627802281&sid=1&Fmt=2&clientId=1564&RQT=309&VName=PQD.

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26

Barbera, Stefano. "The C-type lectin CD93 in physiological and pathological angiogenesis." Doctoral thesis, Università di Siena, 2022. http://hdl.handle.net/11365/1193440.

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Formation of blood vessels is required for development, growth and healing. Although quiescent, endothelial cells (ECs) store a potent proliferative and invasive potential that, upon the appropriate stimuli, is unleashed and gives rise to neovascularization phenomena. Disease progression of cancer and neovascular age-related macular degeneration (nAMD) strongly depends on angiogenesis. In cancer, tumor cells are able to stimulate ECs to become angiogenic and form new blood vessels that allow them to fulfill their tendency to grow and escape the site of the primary tumor. In nAMD, instead
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27

Pees, Barbara [Verfasser]. "The role of C-type lectin-like domain genes in C. elegans immunity / Barbara Pees." Kiel : Universitätsbibliothek Kiel, 2019. http://d-nb.info/1181096685/34.

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28

Blot, Lauriane. "Rôle de CLEC12B dans l'immunité de la peau." Electronic Thesis or Diss., Université Côte d'Azur, 2023. https://intranet-theses.unice.fr/2023COAZ6034.

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CLEC12B a été identifié pour la première fois comme étant un récepteur inhibiteur exprimé par les cellules myéloïdes qui neutralise la cytotoxicité médiée par les cellules NK. CLEC12B est un récepteur de lectine de type C (CLR) possédant un domaine ITIM, mais dont la signalisation en aval et le ou les ligands restent en grande partie inconnus. Au cours des 30 dernières années, une fonction de présentation d'antigène des mélanocytes a émergé en raison de leur nature dendritique, de leur position stratégique dans la peau et de leur capacité phagocytaire. Dans un contexte de vitiligo, notre équip
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Zelensky, Alex N., and Alex Zelensky@anu edu au. "In silico analysis of C-type lectin domains’ structure and properties." The Australian National University. The John Curtin School of Medical Research, 2005. http://thesis.anu.edu.au./public/adt-ANU20050318.185314.

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Members of the C-type lectin domain (CTLD) superfamily are metazoan proteins functionally important in glycoprotein metabolism, mechanisms of multicellular integration and immunity. This thesis presents the results of several computational and experimental studies of the CTLD structure, function and evolution.¶ Core structural properties of the CTLD fold were explored in a comparative analysis of the 37 distinct CTLD structures available publicly, which demonstrate significant structural conservation despite low or undetectable sequence similarity. Pairwise structural alignments of all CTLD s
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Marshall, Andrew. "The characterisation of a novel C-type lectin-like receptor MICL." Thesis, University of Oxford, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.409114.

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Brown, Kristelle. "The role of Mannan binding lectin in hepatitis C virus infection." Thesis, University of Nottingham, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.478973.

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32

Clark, Alexandra Elsie. "Characterisation of the C-type lectin-like receptor 1 (CLEC-1)." Thesis, University of Aberdeen, 2013. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=210080.

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Huysamen, Cristal. "The characterization of a novel C-type lectin-like receptor, CLEC9A." Doctoral thesis, University of Cape Town, 2008. http://hdl.handle.net/11427/3060.

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34

Romain, Gabrielle. "Utilisation de cellules dendritiques en vaccination thérapeutique anti-VIH : approche expérimentale chez le macaque." Thesis, Paris 11, 2011. http://www.theses.fr/2011PA11T040.

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Les lymphocytes T CD8+ jouent un rôle prépondérant dans le contrôle de l’infection par le VIH suggérant ainsi qu’un vaccin efficace doit induire une réponse cellulaire T CD8+ robuste et durable.En fournissant une source antigénique importante qui fait défaut chez les patients répondeurs aux poly-chimiothérapies antirétrovirales, la vaccination thérapeutique pourrait favoriser ce type de réponse cellulaire, non restaurée par les seuls traitements antirétroviraux. Les cellules dendritiques (DC) autologues, qu’elles soient chargées en virus inactivé, en peptides viraux ou en ARN messagers (ARNm)
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Barbosa, Paulo Sérgio Ferreira. "Efeitos renais de miotoxinas e lectinas purificadas dos venenos das serpentes Bothrops jararacussu e Bothrops moojeni : papel da ciclooxigenase e endotelina." reponame:Repositório Institucional da UFC, 2006. http://www.repositorio.ufc.br/handle/riufc/3738.

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BARBOSA, Paulo Sérgio Ferreira. Efeitos renais de miotoxinas e lectinas purificadas dos venenos das serpentes Bothrops jararacussu e Bthrops moojeni : papel da ciclooxigenase e endotelina. 2006. 175 f. Tese (Doutorado em Farmacologia) - Universidade Federal do Ceará. Faculdade de Medicina, Fortaleza, 2006.<br>Submitted by denise santos (denise.santos@ufc.br) on 2012-09-06T11:39:45Z No. of bitstreams: 1 2006_tese_psfbarbosa.pdf: 4134390 bytes, checksum: 386687118259e7d665fe77b7ce37b254 (MD5)<br>Approved for entry into archive by Eliene Nascimento(elienegvn@hotmail.com) on 2012-09-06T12:25:33Z (
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Benmoussa, Khaddouj. "Impact du peptide antimicrobien issu du venin de la fourmi Tetramorium bicarinatum P17 sur la polarisation et l'acquisition des fonctions antifongiques des macrophages humains vis-à-vis de Candida albicans." Thesis, Toulouse 3, 2017. http://www.theses.fr/2017TOU30379/document.

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Les peptides antimicrobiens (PAMs) cationiques sont des molécules amphipatiques conservées chez une grande diversité d'espèces vivantes. Ils participent ainsi à la défense immunitaire de nombreux organismes incluant les bactéries, les insectes, les plantes et les vertébrés. En plus de leur activité microbicide directe dirigée contre un large spectre de pathogènes, la plupart des PAMs cationiques sont désormais connus pour exercer des fonctions immunomodulatrices sur les réponses innée et adaptative. Notre équipe a récemment découvert et isolé un nouveau PAM à partir du venin de la fourmi Tetra
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Mayer-Lambertz, Sabine [Verfasser]. "Role of C-type lectin receptors in bacterial recognition / Sabine Mayer-Lambertz." Hannover : Stiftung Tierärztliche Hochschule Hannover, 2019. http://d-nb.info/1192752465/34.

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Rogers, Sarah Louise. "Characterisation of C-type lectin-like receptor genes in the chicken MHC." Thesis, University of Bristol, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.271871.

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Drummond, Rebcca Anne. "The role of C-type lectin receptors in Candida albicans specific immunity." Thesis, University of Aberdeen, 2014. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=211412.

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Candida albicans is a human fungal pathogen responsible for superficial mucosal infections and life-threatening systemic disease. Despite the availability of potent antifungal drugs, mortality rates of systemic candidiasis remain high. Alternative therapies and vaccines are therefore desirable; however their generation depends on a comprehensive understanding of antifungal immunity. Innate recognition of fungi by the immune system is primarily mediated by a class of myeloid-expressed molecules termed the C-type lectin receptors (CLRs). CLRs mediate a variety of functions including phagocytosis
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Fuchsberger, Felix Franz Robert [Verfasser]. "Quantification of C-type lectin receptors signal transduction / Felix Franz Robert Fuchsberger." Berlin : Freie Universität Berlin, 2021. http://d-nb.info/1235400352/34.

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Verônica, Matoso Maciel de Carvalho Elba. "Determinação do efeito mitogênico das lectinas de Cratylia mollis sobre linfócitos humanos utilizando um método colorimétrico." Universidade Federal de Pernambuco, 2002. https://repositorio.ufpe.br/handle/123456789/1822.

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Made available in DSpace on 2014-06-12T15:52:37Z (GMT). No. of bitstreams: 2 arquivo4957_1.pdf: 431840 bytes, checksum: 73158b1d943a6749588701ae9e0c0060 (MD5) license.txt: 1748 bytes, checksum: 8a4605be74aa9ea9d79846c1fba20a33 (MD5) Previous issue date: 2002<br>Lectinas são proteínas ou glicoproteínas que se ligam a carboidratos específicos. Algumas delas exibem atividade mitogênica sobre linfócitos humanos in vitro ou são tóxicas para estas células em cultura. Estas propriedades estão envolvidas com o sítio de ligação a carboidratos. Neste trabalho foi determinada a atividade mitogênica
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XIMENES, Neila Caroline de Araújo. "urificação e caracterização da lectina da vagem de Caesalpinia ferrea (CfePL) : aplicação biológica." Universidade Federal de Pernambuco, 2004. https://repositorio.ufpe.br/handle/123456789/2066.

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Made available in DSpace on 2014-06-12T15:54:14Z (GMT). No. of bitstreams: 2 arquivo4880_1.pdf: 518828 bytes, checksum: da60dfd8baf692101de8862db743a20d (MD5) license.txt: 1748 bytes, checksum: 8a4605be74aa9ea9d79846c1fba20a33 (MD5) Previous issue date: 2004<br>Lectinas são proteínas que se ligam reversivelmente e especificamente a carboidratos. Caesalpinia ferrea é uma planta com ampla distribuição no Brasil, sendo utilizada em medicina popular. Este trabalho teve como objetivo a purificação e caracterização de lectina da vagem de Caesalpinia ferrea (CfePL). Extrato da vagem (E) em Na
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Cézar, Wanderley Cunha Silva Renato. "Histoquímica com lectinas para Tn e imunohistoquímica para c-erbB-2 na investigação do carcinoma ductal invasivo de mama (CDI)." Universidade Federal de Pernambuco, 2011. https://repositorio.ufpe.br/handle/123456789/9279.

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Made available in DSpace on 2014-06-12T23:13:52Z (GMT). No. of bitstreams: 2 arquivo2950_1.pdf: 1304284 bytes, checksum: e378bb9e29624b94c930b4edfbdd07d5 (MD5) license.txt: 1748 bytes, checksum: 8a4605be74aa9ea9d79846c1fba20a33 (MD5) Previous issue date: 2011<br>Faculdade de Amparo à Ciência e Tecnologia do Estado de Pernambuco<br>O câncer de tecido mamário é o segundo tipo de câncer mais freqüente no mundo e o mais comum entre as mulheres. Dentre os tumores malignos de mama, o carcinoma ductal invasivo (CDI) representam o maior grupo, constituindo cerca de 65 a 80% dos carcinomas mamários.
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Levesque, Jean-Michel. "Étude de la lectine myéloïde inhibitrice de type C (MICL) dans l'arthrite rhumatoïde." Thesis, Université Laval, 2011. http://www.theses.ulaval.ca/2011/28345/28345.pdf.

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Teixeira, Cavalcanti Igor. "Caracterização molecular da lectina ligadora de manose (MBL) em indivíduos com hepatite C." Universidade Federal de Pernambuco, 2007. https://repositorio.ufpe.br/handle/123456789/1830.

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Made available in DSpace on 2014-06-12T15:52:41Z (GMT). No. of bitstreams: 2 arquivo4549_1.pdf: 1671770 bytes, checksum: c5d987dfca24d06cae7f83b502cb6758 (MD5) license.txt: 1748 bytes, checksum: 8a4605be74aa9ea9d79846c1fba20a33 (MD5) Previous issue date: 2007<br>Conselho Nacional de Desenvolvimento Científico e Tecnológico<br>A lectina ligadora de manose (MBL), membro das lectinas tipo-C, apresenta capacidade de se ligar através de múltiplos sítios a várias estruturas de carboidratos e promover a ativação do complemento. Os baixos níveis da MBL estão relacionados com a maior susceptibilidade
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46

Lozach, Pierre-Yves. "Rôles des lectines de type C L-SIGN et DC-SIGN dans l'infection par le virus de l'hépatite C." Paris 6, 2004. http://www.theses.fr/2004PA066211.

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47

Sartim, Marco Aurélio. "Avaliação do envolvimento da Galatrox, uma lectina ligante de lactodr isolada da peçonha de Bothrops atrox, no processo inflamatório." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/60/60134/tde-17062010-114217/.

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Lectinas consistem de um vasto grupo de proteínas de origem não-imunológica e de caráter não enzimático, que reconhecem carboidratos de modo específico e não-covalente. Além disso, essas proteínas participam de vários eventos fisiológicos e patológicos, com embriogenese, resposta imunológica, apoptose, diferenciação celular e câncer. Recentemente, foi purificada da peçonha da serpente Bothrops atrox uma lectina do tipo-C, ligante de lactose, com propriedades bioquímicas e funcionais semelhantes à de outras lectinas de serpentes do gênero, denominada Galatrox. O presente projeto teve como objet
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López, Marcos Alejandro Sulca. "Desenvolvimento de novos peptídeos antimicrobianos a partir de proteínas dos venenos das serpentes peruana Bothrops pictus e Bothriopsis oligolepis." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/46/46131/tde-11042017-083735/.

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A resistência aos antibióticos adquirida por micro-organismos patogênicos é um problema de saúde mundial e, por isso, o desenvolvimento de novos agentes antimicrobianos vem sendo amplamente estimulado. Sabendo que muitos peptídeos bioativos correspondem a fragmentos peptídicos de proteínas e/ou seus análogos, este trabalho teve o objetivo de desenvolver novos peptídeos antimicrobianos (AMPs) a partir das sequências aminoacídicas e das estruturas 3D de proteínas possivelmente envolvidas na atividade antimicrobiana de venenos de serpentes pouco estudados. As etapas iniciais seguidas foram: a) es
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Watson, Aleksandra. "Molecular structure and function of C-type lectin-like molecules in innate immunity." Thesis, University of Oxford, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.504625.

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Maglinao, Maha Fay Binudin [Verfasser]. "C-type lectin receptors in cell-specific targeting and malaria infection / Maha Maglinao." Berlin : Freie Universität Berlin, 2013. http://d-nb.info/1042940037/34.

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