Academic literature on the topic 'C-Mannich'

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Journal articles on the topic "C-Mannich"

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Akiyama, T. "ChemInform Abstract: C-C Bond Formation: Mannich Reaction." ChemInform 44, no. 25 (2013): no. http://dx.doi.org/10.1002/chin.201325216.

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Ran, De Long, Jian Jun Xie, Kai Huang, Shui Ping Yin, Sheng Ming Chen, and Ying She Luo. "High Temperature Resistance of Epoxy Adhesives under the Room-Temperature Curing." Advanced Materials Research 284-286 (July 2011): 1804–7. http://dx.doi.org/10.4028/www.scientific.net/amr.284-286.1804.

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High-temperature resistant epoxy adhesives cured under room-temperature becomes more and more important in many industries such as aerospace and aviation, the locomotive and diesel, etc. In this paper three self-made amine-based mannich-amide was mixed with E-44 epoxy resin under the same technological parameters, and the epoxy adhesives cured by the three amine-based mannich-amides under room-temperature are tested by FTIR, TGA and DMA. Results of TGA show a quicker drop in weight occurrence within 150-250°C for epoxy networks cured by multiamine-based mannich amides than the long-chain alkyl
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Möhrle, Hans, та Georg Keller. "α-Dicarbonylmonohydrazone und ihre Acylderivate als Nucleophile und Nachbargruppen/α-Dicarbonylmonohydrazones and their Acylderivatives as Nucleophiles and Neighbouring Groups". Zeitschrift für Naturforschung B 58, № 9 (2003): 885–902. http://dx.doi.org/10.1515/znb-2003-0911.

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The aminomethylation of the α-carbonylhydrazones 1 and 14 with N,N,N′,N′-tetralkylaminals yields only N,N- or C,N-bis-aminomethyl products, but no C-mono-aminomethyl compounds. Phenylglyoxal N-methylhydrazone (24) yields the Mannich bases 27, while anilinocarbonyl hydrazone 29 dependent on the conditions gives rise to the N-aminomethyl derivatives 30 or to the Mannich bases 31. From benzoylhydrazone 33 and semicarbazone 35 the Mannich bases 34 and 36, respectively, are available. Mercury-EDTA reacts with 27 and 31 by twofold dehydrogenation and cyclization to form the lactams 46 and 47, respec
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Barta, Petra, Ferenc Fülöp, and István Szatmári. "Mannich base-connected syntheses mediated by ortho-quinone methides." Beilstein Journal of Organic Chemistry 14 (March 6, 2018): 560–75. http://dx.doi.org/10.3762/bjoc.14.43.

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This article provides an overview about specifically modified Mannich reactions where the process involves an ortho-quinone methide (o-QM) intermediate. The reactions are classified on the basis of the o-QM source followed by the reactant, e.g., the dienophile partner in cycloaddition reactions (C=C or C=N dienophiles) or by the formation of multicomponent Mannich adducts. Due to the important pharmacological activities of these reactive o-QM intermediates, special attention is paid to the biological activity of these compounds.
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Luo, Yanlong, Huaming Sun, Weiqiang Zhang, et al. "Triple zirconocene/brønsted acid/CuO cooperative and relay catalysis system for tandem Mannich addition/C–C formative cyclization/oxidation." RSC Advances 7, no. 46 (2017): 28616–25. http://dx.doi.org/10.1039/c7ra00870h.

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Li, Ziyi, Li Wang, Yunqi Huang, et al. "Asymmetric Mannich reactions of (S)-N-tert-butylsulfinyl-3,3,3-trifluoroacetaldimines with yne nucleophiles." Beilstein Journal of Organic Chemistry 16 (October 29, 2020): 2671–78. http://dx.doi.org/10.3762/bjoc.16.217.

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In the present work, arylethynes were studied as new C-nucleophiles in the asymmetric Mannich addition reactions with (S)-N-tert-butylsulfinyl-3,3,3-trifluoroacetaldimine. The reactions were conducted under operationally convenient conditions affording the corresponding Mannich adducts with up to 87% yield and 70:30 diastereoselectivity. The isomeric products can be separated using regular column chromatography to afford diastereomerically pure compounds. The purified Mannich addition products were deprotected to give the target enantiomerically pure trifluoromethylpropargylamines. A mechanist
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Han, Peipei, Wenhua Zhou, Mingxia Chen, and Qiuan Wang. "Microwave-assisted Synthesis of Polymethoxychalcone Mannich Bases and Their Antiproliferative Activity." Letters in Organic Chemistry 16, no. 2 (2019): 117–21. http://dx.doi.org/10.2174/1570178615666180627110223.

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A series of eight polymethoxychalcone Mannich base derivatives 2a-2h was synthesized via the microwave-assisted Mannich reaction of natural product 2'-hydroxy-3,4,4',5,6'-pentamethoxychalcone (1) with various secondary amines and formaldehyde. Compared to conventional heating method (80°C), the microwave-assisted method (700W, 65°C) is efficient with short reaction time (0.5-1 h) and good yields (74-88%). The antiproliferative activities of eight Mannich base derivatives were evaluated in vitro on a panel of three human cancer cell lines (Hela, HCC1
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Xie, Chen, Yanling Dai, Haibo Mei, Jianlin Han, Vadim A. Soloshonok та Yi Pan. "Asymmetric synthesis of quaternary α-fluoro-β-keto-amines via detrifluoroacetylative Mannich reactions". Chemical Communications 51, № 44 (2015): 9149–52. http://dx.doi.org/10.1039/c5cc02256h.

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Li, Ziyi, Hua Gao, Haibo Mei, Guangwei Wu, Vadim A. Soloshonok, and Jianlin Han. "Synthesis of Aminoalkyl Sclareolide Derivatives and Antifungal Activity Studies." Molecules 28, no. 10 (2023): 4067. http://dx.doi.org/10.3390/molecules28104067.

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Sclareolide was developed as an efficient C-nucleophilic reagent for an asymmetric Mannich addition reaction with a series of N-tert-butylsulfinyl aldimines. The Mannich reaction was carried out under mild conditions, affording the corresponding aminoalkyl sclareolide derivatives with up to 98% yield and 98:2:0:0 diastereoselectivity. Furthermore, the reaction could be performed on a gram scale without any reduction in yield and diastereoselectivity. Additionally, deprotection of the obtained Mannich addition products to give the target sclareolide derivatives bearing a free N-H group was demo
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She, Yuan Yuan, Xuan Yan Liu, and Zhi Gao Yang. "A Novel Environment Friendly Material: Sucrose Char Sulfonic Acid Catalyzed Three-Component Mannich Reaction." Advanced Materials Research 989-994 (July 2014): 134–37. http://dx.doi.org/10.4028/www.scientific.net/amr.989-994.134.

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Sucrose char sulfonic acid (SCSA) efficiently catalyzed the one-pot, three-component Mannich reaction of ketones, aromatic aldehydes and different amines in ethanol at 30°C and afforded the corresponding β-amino carbonyl compounds in good to excellent yields . This method provides a novel and improved modification of the three-component Mannich reaction in terms of mild reaction conditions , clean reaction profiles and a simple workup procedure.
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Dissertations / Theses on the topic "C-Mannich"

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PELAGALLI, ALESSIA. "Trifluoromethyl and C-alkyl substituted imines in nitro-Mannich and Mannich-type reactions: stereochemical and reactivity studies." Doctoral thesis, 2015. http://hdl.handle.net/11573/863507.

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Composti organici azotati contenenti atomi di fluoro sono importanti target sintetici utilizzati non solo nel contesto della chimica organica, ma anche in campo bio-organico, farmaceutico, medico, come dimostra il crescente numero di farmaci contenenti questo atomo. All’interno di questo ambito si inserisce il mio lavoro di dottorato attraverso il quale ho studiato il confronto della reattività tra immine trifluorometilate e alchil sostituite in reazioni di nitro-Mannich. Infatti la presenza di atomi di fluoro può alterare drasticamente sia il decorso chimico che stereochimico delle reazioni g
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Yalalov, Denis. "Bifunctional Thiourea-Based Organocatalysts for Asymmetric C-C Bond Formation Reactions: Strecker, Nitro-Michael, Mannich." Doctoral thesis, 2007. http://hdl.handle.net/11858/00-1735-0000-0006-ACA2-6.

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Yalalov, Denis [Verfasser]. "Bifunctional thiourea-based organocatalysts for asymmetric C-C bond formation reactions : Strecker, Nitro-Michael, Mannich / vorgelegt von Denis Yalalov." 2007. http://d-nb.info/988878216/34.

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Book chapters on the topic "C-Mannich"

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Akiyama, T. "6.3 C–C Bond Formation: Mannich Reaction." In Comprehensive Chirality. Elsevier, 2012. http://dx.doi.org/10.1016/b978-0-08-095167-6.00603-0.

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Miyaura, N. "C—C Bond Formation via the Boron-Mannich Reaction." In Boron Compounds. Georg Thieme Verlag KG, 2005. http://dx.doi.org/10.1055/sos-sd-006-00246.

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Matsunaga, S. "4.13 Direct C–C Bond Formation (Michael, Aldol, and Mannich)." In Comprehensive Chirality. Elsevier, 2012. http://dx.doi.org/10.1016/b978-0-08-095167-6.00412-2.

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Winkler, J. D., R. D. Scott, and P. G. Williard,. "Synthesis of a Vindorosine Precursor." In Exercises in Synthetic Organic Chemistry. Oxford University PressOxford, 1997. http://dx.doi.org/10.1093/oso/9780198559443.003.0067.

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Abstract Discussion Points What is the mechanism of the protection sequence a, b? Explain the steroselectivities observed in the photochemical reaction of step f and in the Mannich reaction step g. What is the purpose of tetrabutylammonium fluoride in step h? What is the byproduct of step k? Further Reading For reviews on tandem reaction in the synthesis of natural products, see P. J. Parsons, C. S. Penkett and A. J. Shell, Chem. Rev.,1996, 96,195; J. D. Winkler, C. M. Bowen and F. Liotta, Chem. Rev.,1995, 95,2003.
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Taber, Douglass F. "Natural Product Synthesis by C–H Functionalization: (±)-Allokainic Acid (Wee), (–)-Cameroonan-7α-ol (Taber), (+)-Lithospermic Acid (Yu), (–)-Manabacanine (Kroutil), Streptorubin B, and Metacycloprodigiosin (Challis)." In Organic Synthesis. Oxford University Press, 2015. http://dx.doi.org/10.1093/oso/9780190200794.003.0022.

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Andrew G.H. Wee of the University of Regina showed (Org. Lett. 2010, 12, 5386) that with the bulky BTMSM group on N and the electron-withdrawing pivaloyloxy group deactivating the alternative C–H insertion site, the diazo ketone 1 cleanly cyclized to 2, with 21:1 diastereocontrol. Oxidative cleavage of the arene followed by amide reduction and methylenation of the ketone converted 2 into (±)-allokainic acid 3. Intermolecular C–H insertion was the key step in a complementary route to (±)-kainic acid reported (Org. Lett. 2011, 13, 2674) by Takehiko Yoshimitsu of Osaka University. Rh-mediated int
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Taber, Douglass F. "Alkaloid Synthesis: Penaresidin A (Subba Reddy), Allokainic Acid (Saicic), Sedacryptine (Rutjes), Lepistine (Yokoshima/Fukuyama), Septicine (Hanessian), Lyconadin C (Dai)." In Organic Synthesis. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190646165.003.0058.

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Penaresidin A 3, isolated from the Okinawan marine sponge Penares sp., is a potent activator of actomyosin ATPase. B. V. Subba Reddy of the Indian Institute of Chemical Technology prepared (Tetrahedron Lett. 2014, 55, 49) the azetidine ring of 3 by mesyl­ation of the hydroxy sulfonamide 2, derived from 1, followed by cyclization. Allokainic acid 6 has become a useful tool for neurological studies. Radomir N. Saicic of the University of Belgrade found (Org. Lett. 2014, 16, 34) that the Tsuji–Trost cyclization of 4 to 5 proceeded with high diastereoselectivity, presumably by way of the enamine o
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MacMillan, D. W. C., and A. J. B. Watson. "Mannich Processes." In Stereoselective Pericyclic Reactions, Cross Coupling, and C—H and C—X Activation. Georg Thieme Verlag KG, 2011. http://dx.doi.org/10.1055/sos-sd-203-00431.

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Overman, Larry E. "Chapter 3 The 1980s and 90s: Heterocyclization Reactions." In Designing Synthetic Methods and Natural Products Synthesis. GNT Publishing, 2024. http://dx.doi.org/10.47261/1556-3.

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After the invention of the aza-Cope Mannich reaction to solve a stereochemical challenge in our synthesis of gephyrotoxin, we began systematic investigations of this rearrangement. Stimulating these investigations were the high yields we observed in our initial studies, and the attraction that the reaction occurred under neutral conditions at or near room temperature. We estimated that the rate acceleration brought about by incorporation of the charged iminium atom at C-2 in the 2-aza-Cope rearrangement is substantial, on the order of 1010, undoubtedly deriving from the greater delocalization
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"Mannich-Type Reactions." In C-1 Building Blocks in Organic Synthesis 2, edited by van Leeuwen. Georg Thieme Verlag, 2014. http://dx.doi.org/10.1055/sos-sd-213-00179.

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MacMillan, D. W. C., and A. J. B. Watson. "Mannich Processes with Preformed Imines." In Stereoselective Pericyclic Reactions, Cross Coupling, and C—H and C—X Activation. Georg Thieme Verlag KG, 2011. http://dx.doi.org/10.1055/sos-sd-203-00432.

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Conference papers on the topic "C-Mannich"

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Xu, Limin, Tao Chen, Ming Han, and Mohammed Bataweel. "Corrosion Inhibition of Carbon Steel in Carbonate Acidizing at Elevated Temperature." In CONFERENCE 2022. AMPP, 2022. https://doi.org/10.5006/c2022-17562.

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Abstract This paper presents an investigation on the performance of corrosion inhibitors in reducing corrosion loss of N80 steel coupons at high temperature in 15 wt.% and 28 wt.% HCl solutions. This work studied the effect of temperature and acid concentration on corrosion inhibitor performance and provided an efficient corrosion inhibitor for application at elevated temperature of 120°C. Five corrosion inhibitors including Mannich base derivatives and pyridine quaternary ammonium salt were selected. The corrosion rates of N80 steel in concentrated HCl solution with and without corrosion inhi
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Verdes, Anastasia, Elena Gorincioi, Lucian Lupascu, Gheorghe Duca, and Fliur Macaev. "Targeting the bioactive dihydropyrimidines by ecofriendly procedure of biginelli reaction: study case of monastrol." In Scientific seminar with international participation "New frontiers in natural product chemistry". Institute of Chemistry, Republic of Moldova, 2023. http://dx.doi.org/10.19261/nfnpc.2023.ab24.

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Biologically active compounds decorated with dihydropyridine moiety are counted amongst the numerous broad-spectrum therapeutic agents that explain the increasing role of this scaffold in rational drug design [1]. The Biginelli reaction is a multicomponent reaction of aldehyde, (thio)urea, and ß-ketoester, involving Mannich reaction in the first step, which produces multifunctionalized 3,4-dihydropyrimidin-2-(1H)-ones and related heterocyclic compounds [2]. The attractiveness of this acid-catalyzed one-pot condensation reaction lies in the simplicity of grafting the substituent into the struct
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