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Relevant bibliographies by topics / C-nucleoside

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Academic literature on the topic 'C-nucleoside'

Author: Grafiati

Published: 4 June 2021

Last updated: 10 February 2022

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Journal articles on the topic "C-nucleoside"

1

Maeba, Isamu, Masakazu Wakimura, Yasutaka Ito, and Chihiro Ito. "C-Nucleosides. 22. Synthesis of Quinoxaline Acyclo-C-nucleoside." HETEROCYCLES 36, no. 11 (1993): 2591. http://dx.doi.org/10.3987/com-93-6501.

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Rondla, Ramu, Steven J. Coats, Tamara R. McBrayer та ін. "Anti-hepatitis C Virus Activity of Novel β-D-2′-C-methyl-4′-azido Pyrimidine Nucleoside Phosphoramidate Prodrugs". Antiviral Chemistry and Chemotherapy 20, № 2 (2009): 99–106. http://dx.doi.org/10.3851/imp1400.

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Background: 2′- C-methyl and 4′-azido nucleosides have previously demonstrated inhibition of hepatitis C virus (HCV) replication by targeting the RNA-dependent RNA polymerase NS5B. In an effort to discover new and more potent anti-HCV agents, we envisioned synthesizing nucleoside analogues by combining the 2′- C-methylmoiety with the 4′-azido-moiety into one molecule. Methods: 2′- C-methyl-4′-azido pyrimidine nucleosides were synthesized by first converting 2′- C-methyl ribonucleosides to the corresponding 4′-exocyclic methylene nucleosides. Treatment with iodine azide, benzoylation of the 2′-

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Kaczmarek, Renata, Dariusz Korczyński, James R. Green, and Roman Dembinski. "Extension of the 5-alkynyluridine side chain via C–C-bond formation in modified organometallic nucleosides using the Nicholas reaction." Beilstein Journal of Organic Chemistry 16 (January 2, 2020): 1–8. http://dx.doi.org/10.3762/bjoc.16.1.

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Dicobalt hexacarbonyl nucleoside complexes of propargyl ether or esters of 5-substituted uridines react with diverse C-nucleophiles. Synthetic outcomes confirmed that the Nicholas reaction can be carried out in a nucleoside presence, leading to a divergent synthesis of novel metallo-nucleosides enriched with alkene, arene, arylketo, and heterocyclic functions, in the deoxy and ribo series.

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MAEBA, I., M. WAKIMURA, Y. ITO, and C. ITO. "ChemInform Abstract: C-Nucleosides. Part 22. Synthesis of Quinoxaline Acyclo-C-Nucleoside." ChemInform 25, no. 11 (2010): no. http://dx.doi.org/10.1002/chin.199411183.

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Hassan, Mohamed Ezeldin. "Palladium-catalyzed cross-coupling reaction of organostannanes with nucleoside halides." Collection of Czechoslovak Chemical Communications 56, no. 9 (1991): 1944–47. http://dx.doi.org/10.1135/cccc19911944.

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A general reaction is described for the synthesis of C-5 substituted nucleosides through the coupling of organostannanes with nucleoside-palladium intermediate derived in situ from 5-iodouridine (or 5-iodo-2’-deoxyuridine) and [PdCl2(PPh3)2]. The reaction was used for the synthesis of C-5 aryl, heteroaryl, vinyl, allyl and alkyl substituted nucleosides.

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Grouiller, Annie, and Hassan Essadiq. "Behaviour of 2′-O-p-toluenesulfonyl uridine towards excess of a Grignard reagent." Canadian Journal of Chemistry 67, no. 4 (1989): 708–9. http://dx.doi.org/10.1139/v89-108.

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Two C-methylated base nucleosides were obtained when 2′-O-tosyl-5′-O-trityluridine was reacted with 30 equivalents of methylmagnesium iodide. Keywords: nucleoside, Grignard reaction, C-methyl pyrimidinone, anhydro derivative, arabinofuranosyl.

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Iwasaki, Hiromichi, Peng Huang, Michael J. Keating, and William Plunkett. "Differential Incorporation of Ara-C, Gemcitabine, and Fludarabine Into Replicating and Repairing DNA in Proliferating Human Leukemia Cells." Blood 90, no. 1 (1997): 270–78. http://dx.doi.org/10.1182/blood.v90.1.270.

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Abstract The major actions of nucleoside analogs such as arabinosylcytosine (ara-C) and fludarabine occurs after their incorporation into DNA, during either replication or repair synthesis. The metabolic salvage and DNA incorporation of the normal nucleoside, deoxycytidine, is functionally compartmentalized toward repair synthesis in a process regulated by ribonucleotide reductase. The aim of this study was to investigate the metabolic pathways by which nucleoside analogs that do (fludarabine, gemcitabine) or do not (ara-C) affect ribonucleotide reductase are incorporated into DNA in prolifera

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Iwasaki, Hiromichi, Peng Huang, Michael J. Keating, and William Plunkett. "Differential Incorporation of Ara-C, Gemcitabine, and Fludarabine Into Replicating and Repairing DNA in Proliferating Human Leukemia Cells." Blood 90, no. 1 (1997): 270–78. http://dx.doi.org/10.1182/blood.v90.1.270.270_270_278.

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The major actions of nucleoside analogs such as arabinosylcytosine (ara-C) and fludarabine occurs after their incorporation into DNA, during either replication or repair synthesis. The metabolic salvage and DNA incorporation of the normal nucleoside, deoxycytidine, is functionally compartmentalized toward repair synthesis in a process regulated by ribonucleotide reductase. The aim of this study was to investigate the metabolic pathways by which nucleoside analogs that do (fludarabine, gemcitabine) or do not (ara-C) affect ribonucleotide reductase are incorporated into DNA in proliferating huma

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Ogawa, Jun, Sou Takeda, Sheng-Xue Xie, et al. "Purification, Characterization, and Gene Cloning of Purine Nucleosidase from Ochrobactrum anthropi." Applied and Environmental Microbiology 67, no. 4 (2001): 1783–87. http://dx.doi.org/10.1128/aem.67.4.1783-1787.2001.

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ABSTRACT A bacterium, Ochrobactrum anthropi, produced a large amount of a nucleosidase when cultivated with purine nucleosides. The nucleosidase was purified to homogeneity. The enzyme has a molecular weight of about 170,000 and consists of four identical subunits. It specifically catalyzes the irreversibleN-riboside hydrolysis of purine nucleosides, theKm values being 11.8 to 56.3 μM. The optimal activity temperature and pH were 50°C and pH 4.5 to 6.5, respectively. Pyrimidine nucleosides, purine and pyrimidine nucleotides, NAD, NADP, and nicotinamide mononucleotide are not hydrolyzed by the

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Kryczka, Tomasz, Maciej Bero, Janusz Kasperczyk, et al. "In vitro release of cytotoxic nucleoside analogs from lactide-caprolactone and lactide-glycolide copolymers." Acta Biochimica Polonica 49, no. 1 (2002): 205–10. http://dx.doi.org/10.18388/abp.2002_3837.

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The aims of our study were to assess the release of cytotoxic nucleoside analogs 5-fluorouracil and 2-chloro-2'-deoxyadenosine from different lactide-glycolide or lactide-caprolactone biodegradable copolymers and the effects of sterilization on this release. The polymers were sterilized either with ethylene oxide at 37 degrees C, or with gamma radiation (15 kGy, 20 kGy, or 25 kGy). The kinetics of nucleoside release from the copolymers were measured over 50 days. Four copolymers exhibited relatively constant release of nucleosides in micromolar concentrations during the entire observation peri

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Dissertations / Theses on the topic "C-nucleoside"

1

Kirkman, Joseph. "Synthesis of Heterocyclic C-Nucleoside Mimics." Thesis, University of Exeter, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.531679.

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Chan, Heng Ming. "Synthesis of pyrimidine C-nucleoside analogues and triphosphate derivatives." Thesis, Boston College, 2008. http://hdl.handle.net/2345/36.

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Five pyrimidine C-nucleosides were prepared via Heck-type coupling reactions. These derivatives are designed to mimic dC and dU (or T). The minor groove O2 carbonyl in each derivative is replaced by a hydrogen, a fluorine, or a methyl group. The hydrogen-substituted dC analogue was converted into a 2’,3’-dideoxynucleoside, which was converted into a 5’-triphosphate derivative. The other two dC analogues were transformed into 5’-triphosphate derivatives immediately after Heck coupling reactions. These analogues will allow an examination of the nature and role of minor groove interactions betwee

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Stefan, Carmen Mirela. "Synthesis of C-nucleoside analogues for mechanistic study of uracil DNA glycosylase." [Gainesville, Fla.] : University of Florida, 2004. http://purl.fcla.edu/fcla/etd/UFE0002412.

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Loemba, Hugues D. "Genotypic and phenotypic characteristics of HIV-1 clade C resistant variants selected in vitro against nucleoside and non-nucleoside inhibitors of reverse transcriptase." Thesis, McGill University, 2001. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=38225.

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This thesis project was designed to investigate the phenotypic and genotypic variability of human immunodeficiency virus type 1 (HIV-1) drug-naive clade C reverse transcriptase (RT) and its potential impact in the development of resistance against inhibitors of RT. Five treatment-naive HIV-1 Ethiopian isolates were classified as subtype C on the basis of env gene heteroduplex mobility assays (HMA) profile and phylogenetic analysis of RT sequences. In subtype C RT, a specific KVEQ motif of silent mutations (amino acid 65, 106, 138, 161) at resistance sites was present. Two Ethiopian strains wer

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Grand, Simon Christopher. "The synthesis of carbocyclic nucleoside analogues using rhodium carbenoid C-H insertion reactions." Thesis, University of Nottingham, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.367403.

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Marcé, Villa Patricia. "Hydroacylation and C-N Coupling Reactions. Mechanistic Studies and Application in the Nucleoside Synthesis." Doctoral thesis, Universitat Rovira i Virgili, 2008. http://hdl.handle.net/10803/9026.

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The PhD work "Hydroacylation and C-N coupling Reactions. Mechanistic Studies and Application in the Nucleoside Synthesis" tackle two different objectives, a) developing new methods of synthesis of nucleosides (introduction, and chapters 1 and 2) and b) to carry out a mechanistic study of the intermolecular hydroacylation and hydroiminoacylation reaction with and cationic rhodium complexes (chapter 3). <br/>Concerning the synthesis nucleosides, in chapter 1 we have explored new methods of synthesis of 2',3'-dideoxynucleosides and isonucleosides using a palladium or copper catalyzed C-N coupling

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Robinson, N. G. "New amino acid syntheses : Applications to studies on penicillin biosynthesis and C-nucleoside synthesis." Thesis, University of Oxford, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.375322.

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Cheng, Kwan-wai. "Regulation of equilibrative nucleoside transporter-1 by protein kinase C and mitogen-activating protein kinase /." View the Table of Contents & Abstract, 2005. http://sunzi.lib.hku.hk/hkuto/record/B31494912.

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Liang, Yong. "Novel Approaches for the Synthesis of C-5 Modified Pyrimidine Nucleosides." FIU Digital Commons, 2014. http://digitalcommons.fiu.edu/etd/1591.

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The antiviral or anticancer activities of C-5 modified pyrimidine nucleoside analogues validate the need for the development of their syntheses. In the first half of this dissertation, I explore the Pd-catalyzed cross-coupling reaction of allylphenylgermanes with aryl halides in the presence of SbF5/TBAF to give various biaryls by transferring multiple phenyl groups, which has also been applied to the 5-halo pyrimidine nucleosides for the synthesis of 5-aryl derivatives. To avoid the use of organometallic reagents, I developed Pd-catalyzed direct arylation of 5-halo pyrimidine nucleosides. It

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Cong, Mei. "Design, synthesis and characterization of novel triazole nucleoside analogues." Thesis, Aix-Marseille, 2015. http://www.theses.fr/2015AIXM4018.

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Les analogues de nucléosides sont d'une importance considérable dans la recherche de nouveaux candidats médicaments antiviraux et anticancéreux. La ribavirine est en effet le premier nucléoside triazole antiviral synthétique. Elle est toujours activement utilisée en milieu hospitalier pour le traitement de l'hépatite C et celui des pandémies virales émergentes. Récemment, le besoin de nouveaux agents thérapeutiques efficaces dotés de nouveaux mécanismes d'action a donc créé un regain d'intérêt dans la création de nouvelles entités structurelles de nucléosides triazoles. Au cours de mon doctora

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Books on the topic "C-nucleoside"

1

Mohr, Marion. Pseudouridin, ein natürlich vorkommendes C-Nucleosid, und seine Verwendung in der Oligonucleotidsynthese. Hartung-Gorre, 1992.

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Book chapters on the topic "C-nucleoside"

1

Carroll, Steven S., and Robert L. LaFemina. "Nucleoside Analog Inhibitors of Hepatitis C Viral Replication." In Antiviral Research. ASM Press, 2014. http://dx.doi.org/10.1128/9781555815493.ch9.

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Postel, E. H. "NM23/Nucleoside Diphosphate Kinase as a Transcriptional Activator of c-myc." In Current Topics in Microbiology and Immunology. Springer Berlin Heidelberg, 1996. http://dx.doi.org/10.1007/978-3-642-61109-4_11.

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Franchetti, P., L. Cappellacci, M. Grifantini, H. N. Jayaram, and B. M. Goldstein. "C-Nucleoside Analogs of Tiazofurin and Selenazofurin as Inosine 5'-Monophosphate Dehydrogenase Inhibitors." In ACS Symposium Series. American Chemical Society, 2003. http://dx.doi.org/10.1021/bk-2003-0839.ch011.

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4

Miras-Portugal, M. Teresa, Esmerilda G. Delicado, Teresa Casillas, and Raquel P. Sen. "Control of Nucleoside Transport in Neural Cells Effect of Protein Kinase C Activation." In Advances in Experimental Medicine and Biology. Springer US, 1991. http://dx.doi.org/10.1007/978-1-4899-2638-8_100.

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Liu, Yaya, Yupeng He, and Akhteruzzaman Molla. "Hepatitis C Virus Polymerase as a Target for Antiviral Drug Intervention: Non-Nucleoside Inhibitors." In Antiviral Research. ASM Press, 2014. http://dx.doi.org/10.1128/9781555815493.ch8.

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Beaulieu, Pierre L. "CHAPTER 8. Design and Development of NS5B Polymerase Non‐nucleoside Inhibitors for the Treatment of Hepatitis C Virus Infection." In Drug Discovery. Royal Society of Chemistry, 2013. http://dx.doi.org/10.1039/9781849737814-00248.

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7

Watanabe, Kyoichi A. "The Chemistry of C-Nucleosides." In Chemistry of Nucleosides and Nucleotides. Springer US, 1994. http://dx.doi.org/10.1007/978-1-4757-9667-4_5.

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Jalluri, Ravi K., Young H. Yuh, and E. Will Taylor. "O—C—N Anomeric Effect in Nucleosides." In ACS Symposium Series. American Chemical Society, 1993. http://dx.doi.org/10.1021/bk-1993-0539.ch015.

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Crisalli, Pete, and Eric T. Kool. "Fluorescent C-Nucleosides and their Oligomeric Assemblies." In Fluorescent Analogs of Biomolecular Building Blocks. John Wiley & Sons, Inc, 2016. http://dx.doi.org/10.1002/9781119179320.ch14.

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Vismara, E., F. Minisci, and F. Fontana. "New Procedures of Homolytic Alkylation of Heteroaromatic Bases: Synthesis of C-Nucleosides." In Organic Free Radicals. Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-73963-7_112.

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Conference papers on the topic "C-nucleoside"

1

Siqueira, Edmilson Clarindo de, Alexander Y.Nazarenko, and Bogdan Doboszewski. "Dehydration of D-mannitol: building block for C-nucleoside synthesis." In 14th Brazilian Meeting on Organic Synthesis. Editora Edgard Blücher, 2013. http://dx.doi.org/10.5151/chempro-14bmos-r0023-2.

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Hamann, Marie, Claire Pierra, Jean-Pierre Sommadossi, et al. "Synthesis and antiviral evaluation of 7,9-dideaza-8-thiapurine C-nucleoside derivatives." In XIVth Symposium on Chemistry of Nucleic Acid Components. Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 2008. http://dx.doi.org/10.1135/css200810347.

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Smits, Helmars, Māris Turks, Dace Katkevica, and Ērika Bizdēna. "Synthesis of protected 3,5-dideoxy-3-C-azidomethyl-D-allofuranose, precursor of 3',5'-C-modified nucleoside analogs." In XIth Symposium on Chemistry of Nucleic Acid Components. Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 1999. http://dx.doi.org/10.1135/css199902039.

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Sedláček, Ondřej, Radek Pohl, and Antonín Holý. "Synthesis of 8-C-substituted 2,6-diaminopurine acyclic nucleoside phosphonates by Negishi cross-coupling." In XIVth Symposium on Chemistry of Nucleic Acid Components. Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 2008. http://dx.doi.org/10.1135/css200810449.

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Gazivoda, Tatjana, Silvana Raić-Malić, Sandra Kraljević-Pavelić, Krešimir Pavelić, Jan Balzarini, and Mladen Mintas. "The new unsaturated acyclic C-5 pyrimidine nucleoside analogues: synthesis, cytostatic and anti-HIV evaluations." In XIVth Symposium on Chemistry of Nucleic Acid Components. Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 2008. http://dx.doi.org/10.1135/css200810439.

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Liu, Xiaojun, Akira Matsuda, and William Plunkett. "Abstract 3638: DNA strand breaks induced by 2′-C-cyano-2′-deoxy-nucleoside analogs are repaired by homologous recombination." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-3638.

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Fernández-Calotti, Paula, Albert Català, MarÇal Pastor-Anglada, Roberta Malatesta, Susana Rives, and Mireia Camos. "Abstract C46: Implication of FLT3 in human equilibrative nucleoside transporter 1 (hENT1)-mediated uptake of Ara-C in pediatric acute leukemia." In Abstracts: AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics--Oct 19-23, 2013; Boston, MA. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1535-7163.targ-13-c46.

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Štambaský, Jan, Pavel Kočovský, and Michal Hocek. "Towards a novel approach to C-nucleosides." In XIIIth Symposium on Chemistry of Nucleic Acid Components. Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 2005. http://dx.doi.org/10.1135/css200507277.

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Čerňa, Igor, and Michal Hocek. "Direct C–H arylation of purines and purine nucleosides." In XIVth Symposium on Chemistry of Nucleic Acid Components. Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 2008. http://dx.doi.org/10.1135/css200810327.

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Kubelka, Tomáš, Martin Štefko, Jan Bárta, et al. "Development of a general and modular approach to C-nucleosides." In XVth Symposium on Chemistry of Nucleic Acid Components. Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 2011. http://dx.doi.org/10.1135/css201112180.

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