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Journal articles on the topic 'C1 level'

Author: Grafiati

Published: 4 June 2021

Last updated: 27 July 2025

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1

Schmaier, AH, S. Amenta, T. Xiong, GD Heda, and AM Gewirtz. "Expression of platelet C1 inhibitor." Blood 82, no. 2 (1993): 465–74. http://dx.doi.org/10.1182/blood.v82.2.465.465.

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Abstract Human platelets contain a pool of C1 inhibitor (C1 INH) distinct from that in plasma. Twelve normal platelet samples washed by centrifugation had a mean platelet C1 INH antigen level of 19.3 +/- 2.8 ng (mean +/- SEM) per 10(8) platelets. These values contrast with the mean +/- SEM platelet C1 INH antigen level of 6.1 +/- 0.9 per 10(8) platelets from 12 C1 INH-deficient patients. The level of platelet C1 INH correlated (r = .7) with the level of plasma C1 INH in normal individuals and patients with classic hereditary angioedema. Platelet C1 INH, like plasma C1 INH, was a 105-Kd protein

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Schmaier, AH, S. Amenta, T. Xiong, GD Heda, and AM Gewirtz. "Expression of platelet C1 inhibitor." Blood 82, no. 2 (1993): 465–74. http://dx.doi.org/10.1182/blood.v82.2.465.bloodjournal822465.

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Human platelets contain a pool of C1 inhibitor (C1 INH) distinct from that in plasma. Twelve normal platelet samples washed by centrifugation had a mean platelet C1 INH antigen level of 19.3 +/- 2.8 ng (mean +/- SEM) per 10(8) platelets. These values contrast with the mean +/- SEM platelet C1 INH antigen level of 6.1 +/- 0.9 per 10(8) platelets from 12 C1 INH-deficient patients. The level of platelet C1 INH correlated (r = .7) with the level of plasma C1 INH in normal individuals and patients with classic hereditary angioedema. Platelet C1 INH, like plasma C1 INH, was a 105-Kd protein on immun

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Emelyanov, A. V., E. V. Leshenkova, and G. A. Kameneva. "Diagnosis and treatment of hereditary angioedema with normal C1-inhibitor level." Terapevticheskii arkhiv 92, no. 12 (2020): 86–90. http://dx.doi.org/10.26442/00403660.2020.12.200447.

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Hereditary angioedema (HAE) with normal C1-inhibitor level is a rare potentially life-threatening disorder with autosomal dominant inheritance which was first described in 2000. Its clinical presentation is similar to HAE with C1-deficiency. The review is summarized data about its prevalence, mechanisms, genetics and diagnostic criteria. Different subtypes and treatment options (on demand, short term and long-term prophylaxis) are discussed. We describe family clinical cases of 2 female patients with normal C1-inhibitor and plasminogen gene mutation. Their features were late diagnosis (in 10 a

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Tarukado, Kiyoshi, Ko Ikuta, Keiichiro Iida, Osamu Tono, Toshio Doi, and Katsumi Harimaya. "Radiographic and Clinical Results of C1 Laminoplasty for the Treatment of Compressive Myelopathy." Asian Spine Journal 14, no. 4 (2020): 459–65. http://dx.doi.org/10.31616/asj.2019.0190.

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Study Design: Case series.Purpose: To evaluate the radiographic and clinical results of C1 laminoplasty without fusion.Overview of Literature: C1 laminectomy has been the standard procedure for decompression at the C1 level. However, there have been some reports of trouble cases after C1 laminectomy. C1 laminoplasty might be superior to C1 laminectomy with regard to maintaining the original C1 anatomical shape, preventing compression from the posterior soft tissue, and ensuring an adequate bonegrafting site around the C1 posterior part if additional salvage fusion surgery is necessary afterwar

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Armbrust, T., S. Schwögler, G. Zöhrens, and G. Ramadori. "C1 esterase inhibitor gene expression in rat Kupffer cells, peritoneal macrophages and blood monocytes: modulation by interferon gamma." Journal of Experimental Medicine 178, no. 2 (1993): 373–80. http://dx.doi.org/10.1084/jem.178.2.373.

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Kupffer cells (KC) represent the main part of the tissue macrophages. Beside phagocytosis of particulate material, involvement of KC in immunological and inflammatory reactions has been supposed. As C1 esterase inhibitor (C1-INH) is a serine protease inhibitor involved in such processes, the aim of this work was to study C1-INH synthesis in KC and, by comparison, in peritoneal macrophages (PM) and blood monocytes (MC) of the rat. C1-INH synthesis was studied on the protein level by biosynthetic labeling, immunoprecipitation, and sodium dodecyl sulfate-polyacrylamide gel electrophoresis analysi

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Sari, Yurista, Riskan Qadar, and Abdul Hakim. "Analysis of High School Students' Conceptual Understanding of Physics on Temperature and Heat Concepts." International Journal of STEM Education for Sustainability 3, no. 1 (2023): 212–24. http://dx.doi.org/10.53889/ijses.v3i1.92.

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This study aimed to determine the mastery of the concept of students on material temperature and heat. This research is a qualitative descriptive study. The research subjects were class XI students of school A Samarinda, school B Samarinda, school C Samarinda, and school D Samarinda. The data collection technique used was purposive sampling. Data on concept mastery was obtained using a multiple-choice test instrument totaling 24 items based on the revised bloom taxonomy indicator. The research results on mastering the concept of school A Samarinda at C1 level 79%, C2 level 67%, C3 level 63%, C

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Murahashi, Yasutaka, Tsuneo Takebayashi, Yoshinori Terashima, Hajime Tsuda, Mitsunori Yoshimoto, and Toshihiko Yamashita. "Clinical Presentation of Cervical Myelopathy at C1–2 Level." Asian Spine Journal 10, no. 4 (2016): 755. http://dx.doi.org/10.4184/asj.2016.10.4.755.

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Schuermans, Valérie Nicole Elise, Jasper van Aalst, Alida A. Postma, and Anouk Y. J. M. Smeets. "Ossification of the posterior longitudinal ligament at the craniocervical junction presenting with Brown-Séquard syndrome: A case report." Surgical Neurology International 12 (October 6, 2021): 501. http://dx.doi.org/10.25259/sni_704_2021.

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Background: Several case reports about spinal cord compression due to hyperostosis at the craniocervical junction are available. However, compression at C1-C2 solely due to ossification of the posterior longitudinal ligament (OPLL) is rare. Case Description: A 50-year-old Asian male, with a history of lumbar spinal canal stenosis, presented with a progressive quadriparesis within 3 months. Imaging showed central OPLL at the C1-C2 level contributing to severe spinal cord compression. The patient improved neurologically after a C1-C2 laminectomy. Conclusion: A patient presented with a progressiv

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Al-Kindi, Ahmad Ghufron, Suka Handaja Budi, and Astrie Kusuma Dewi. "TUNING CONTROL CASCADE LEVEL FLOW PADA KOLOM DE-ETHANIZER MENGGUNAKAN METODE ZIEGLER NICHOLS." Prosiding Seminar Nasional Teknologi Energi dan Mineral 2, no. 1 (2022): 1147–55. http://dx.doi.org/10.53026/sntem.v2i1.678.

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Column De-ethanizer merupakan alat yang terpenting dalam pemisahan C1,C2 dengan C3+. Kolom De-ethanizer bekerja berdasarkan perbedaan titik didih, dengan demikian titik didih yang rendah akan menguap ke atas sedangkan titik didih yang tinggi akan turun ke bawah, C1 dan C2 akan menguap ke atas karena titik didihnya lebih rendah dibandingkan dengan C3+. C1 dan C2 yang menguap ke atas menuju Top De-ethanizer akan menjadi lean gas. Sementara C3+ akan jatuh ke bawah melewati tray menjadi produk NGL ( Natural Gas Liquid ). Proses pengendalian di Kolom De-ethanizer bertujuan untuk menjaga level gas t

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Makunina, Eleonora, Larisa Mendeleeva, Vadim L. Surin, et al. "Effect of MAGE-C1 Gene Expression on Prognosis and Effectiveness of Bortezomib-Containing Courses in Multiple Myeloma." Blood 138, Supplement 1 (2021): 4327. http://dx.doi.org/10.1182/blood-2021-150283.

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Abstract Introduction. The group of genes, encoding cancer-testis antigens is actively studied as a new markers of refractory in some diseases, including multiple myeloma (MM). It is suggested that the MAGE-C1 gene in MM may be considered as an additional marker predicting the effectiveness of therapy. Purpose. Determine of MAGE-C1 gene expression by quantitative real-time polymerase chain reaction (qRT-PCR) in MM patients and assess the correlation of expression with some laboratory parameters and response on bortezomib-containing therapy. Patients and methods. A prospective study from Februa

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Aldrich, E. Francois, Peter B. Weber, and Wayne N. Crow. "Halifax interlaminar clamp for posterior cervical fusion: a long-term follow-up review." Journal of Neurosurgery 78, no. 5 (1993): 702–8. http://dx.doi.org/10.3171/jns.1993.78.5.0702.

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✓ Fifty consecutive patients requiring posterior cervical fusion for various pathologies were treated with Halifax interlaminar clamps for internal spinal fixation. Fusion involved the C1–2 level in 17 cases, the C1–3 level in one, and the lower cervical area (C2–7) in 32. No patient was lost to follow-up review, which varied from 6 to 40 months (average 21 months). Fusion failed in five patients, three at the C1–2 level, one at the C1–3 level, and one at the C2–3 level. Screw loosening was the cause of failure in four patients, and in one the arch of C-1 fractured. No other complications occu

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Wonnaparhown, Alex, Alexandra Stefanovic, Patricia Lugar, and Haley P. Hostetler. "Acquired angioedema in B cell lymphoproliferative disease: A retrospective case series." Clinical and Experimental Immunology 206, no. 3 (2021): 378–83. http://dx.doi.org/10.1111/cei.13667.

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Abstract Acquired angioedema due to C1-inhibitor (C1-INH) deficiency (AAE-C1-INH) is rare and is associated with underlying lymphoproliferative diseases. C1-INH deficiency may be due to neoplastic over-consumption of C1-INH and the generation of anti-C1-INH autoantibodies. Uncovering an occult malignancy can lead to earlier oncology referral and improvement of angioedema after treatment of the underlying lymphoproliferative disorder. We characterized seven patients with C1-INH-AAE that highlights the importance of recognizing the association between C1-INH-AAE and underlying malignancy. In acu

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V. S., Gopika, G. Prasad, and Mimitha A. S. "Effect of Simarouba glauca Leaf Aqueous Extract on the Growth, Immunological, Haematological and Biochemical Parameters of Oreochromis Niloticus." Mapana Journal of Sciences 23, no. 1 (2024): 121–34. https://doi.org/10.12723/mjs.68.6.

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The present study was conducted to evaluate the effect of aqueous leaf extract of Simarouba glauca on the growth, haematology, immunological and biochemical parameters of Oreochromis niloticus. Concentrations ranging from 2500mg /kg to 7500mg/kg were supplemented through diet. Fishes were fed with C1(2500 mg of plant extract/kg of basal diet), C2 (5000 mg/kg of basal diet) and C3 (2500 mg/kg of basal diet), each with two replicates for 60 days. The results showed that fish-fed dietary Simarouba glauca gained more weight in C1 (83.14 ±1.11 g) than control (P< 0.01). Fish fed with C1 had a hi

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Werle, Stephan, Ali Ezzati, Hesham ElSaghir, and Heinrich Boehm. "Is inclusion of the occiput necessary in fusion for C1–2 instability in rheumatoid arthritis?" Journal of Neurosurgery: Spine 18, no. 1 (2013): 50–56. http://dx.doi.org/10.3171/2012.10.spine12710.

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ObjectThe atlantoaxial joint is the location most and earliest affected in patients with rheumatoid arthritis (RA). In longstanding disease, ligamentous and osseous destruction can progress and involve all cervical segments. If surgical intervention is necessary, some prefer, to be safe, undertaking fusion to the occiput, whereas others advocate 1-level fusion of C1–2. Sparing the occiput (Oc)–C1 segment would allow retention of a considerable amount of physiological range of motion and seems beneficial against subaxial overload. Previous clinical studies on this topic have provided only nonsp

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15

Chowdhury, Forhad H., Mohammod Raziul Haque, Maliha Hakim, Mohammod Shamsul Arifin, and Soyed Ariful Islam. "Bilateral Accessory C1 and C2 Facet Joints; Clinical, Neuroradiological and Peroperative Findings in an Adult with Quadriparesis." Arquivos Brasileiros de Neurocirurgia: Brazilian Neurosurgery 38, no. 04 (2019): 328–35. http://dx.doi.org/10.1055/s-0039-1688460.

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Objectives Accessory C1 and C2 facet joints are very rare. Only few cases were reported in the literature. We report a case of bilateral accessory facets in an adult with special attention to clinical, neuroradiological, as well as peroperative findings. Case report A 37-year-old male presented with progressive quadriparesis. Radiology revealed bilateral posterior accessory C1 and C2 facet joints compressing the spinal cord with craniovertebral junction (CVJ) instability. Both accessory C1 and C2 facets with the posterior arch of the C1 were removed. Lateral mass screws and plates fixation at

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Kang, H. R., E. Y. Yim, S. Y. Oh, et al. "Normal C1 inhibitor mRNA expression level in type I hereditary angioedema patients: newly found C1 inhibitor gene mutations." Allergy 61, no. 2 (2006): 260–64. http://dx.doi.org/10.1111/j.1398-9995.2006.01010.x.

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Varga, Lilian A., Dorottya Csuka, George Füst, et al. "Functional C1-inhibitor level increases during attacks of hereditary angioedema." Immunobiology 217, no. 11 (2012): 1172–73. http://dx.doi.org/10.1016/j.imbio.2012.08.126.

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Wu, Xiaodong, Dazhi Li, Lu Zhang, and Yanming Li. "A giant spinal schwannoma at the C1-C2 level: A case report." Medicine 104, no. 1 (2025): e41258. https://doi.org/10.1097/md.0000000000041258.

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Rationale: Giant spinal schwannomas located at the C1-C2 level pose significant surgical challenges because of their proximity to the brainstem, cervical spinal cord, and vertebral arteries. This case provides insight into the surgical management of giant spinal schwannomas at the C1-C2 level. Patient Concerns: A 40-year-old female presented with a 2-year history of progressive limb numbness, weakness, and gait instability. She reported a sensation of stepping on cotton and tightness in the chest and abdomen with worsening symptoms over time. Diagnoses: Physical examination revealed limited ce

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Huisman, L. G. M., J. M. T. van Griensven, and C. Kluft. "On the Role of C1-Inhibitor as Inhibitor of Tissue-type Plasminogen Activator in Human Plasma." Thrombosis and Haemostasis 73, no. 03 (1995): 466–71. http://dx.doi.org/10.1055/s-0038-1653798.

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SummaryAn enzyme immuno assay was developed to measure complexes of tissue-type plasminogen activator (t-PA) with C1-inhibitor in order to study the role of C1-inhibitor as an inhibitor of t-PA in plasma. In vitro experiments with melanoma and recombinant t-PA learned that purified C1-inhibitor reacts with both single chain t-PA and two chain t-PA. The rate constants ranged from 3.0 to 5.2 M-1s-1 In plasma, melanoma and recombinant two chain t-PA were hardly inhibited by C1-inhibitor, in contrast to melanoma and recombinant single chain t-PA which were inhibited to the same extent by endogenou

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Kumar, Ashish, Suchanda Bhattacharjee, and Barada Sahu. "Importance of C1 laminectomy in foramen magnum decompression surgery: A technical note." Asian Journal of Neurosurgery 9, no. 04 (2014): 235. http://dx.doi.org/10.4103/1793-5482.146627.

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Arnold-Chiari malformations (ACM) of the brain result from aberrations in the development of the posterior fossa resulting in its smaller volume leading to tonsillar herniation. The most common type includes Type I ACM where tonsillar descent reaches up to either C1 or C2 along with cervico-dorsal syringomyelia. The surgery (foramen magnum decompression, [FMD]) is usually straight forward and includes sub-occipital craniectomy and cervical laminectomy based on the level of descent. Rarely inadequate cervical laminectomy of C1 arch may result in residual compression at the level of obex even af

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Ardelean, Alina Ioana, Madalina Florina Dragomir, Marioara Moldovan, et al. "In Vitro Study of Composite Cements on Mesenchymal Stem Cells of Palatal Origin." International Journal of Molecular Sciences 24, no. 13 (2023): 10911. http://dx.doi.org/10.3390/ijms241310911.

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Uniform filler distribution in composites is an important requirement. Therefore, BaO glass, nano hydroxyapatite and quartz filler distribution was realized through PCL microcapsules which progressively release filler during matrix polymerization. Two composites were realized based on a complex matrix containing BisGMA, UDMA, HEMA and PEG400 mixed with a previously described mineral filler: 33% for C1 and 31% for C2. The spreading efficiency was observed via SEM, revealing a complete disintegration of the microcapsules during C1 polymerization, while C2 preserved some microcapsule parts that w

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Moraes, Caroline Guth de Freitas Batista de, Liya Regina Mikami, Lilian Pereira Ferrari, João Bosco Pesquero, Herberto José Chong-Neto, and Nelson Augusto Rosario Filho. "Short-term Prophylaxis for Delivery in Pregnant Women with Hereditary Angioedema with Normal C1-Inhibitor." Revista Brasileira de Ginecologia e Obstetrícia / RBGO Gynecology and Obstetrics 42, no. 12 (2020): 845–48. http://dx.doi.org/10.1055/s-0040-1718955.

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Abstract Objective To verify the efficacy of short-term prophylaxis for vaginal or cesarean section childbirth with plasma-derived C1-inhibitor concentrate in pregnant women. They should have hereditary angioedema (HAE) and normal plasma C1-inhibitor. Methods Case report of pregnant women diagnosed with HAE with normal C1-inhibitor who had been treated with intravenous C1-inhibitor concentrate for prophylaxis of angioedema attacks when hospitalized for delivery. The exon 9 of the Factor 12 (F12) genotyping gene was performed by automatic sequencing in all patients. Results Three cases of pregn

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Visy, Beáta, Tamás Szilágyi, Kinga Viktória Kőhalmi, et al. "A D3-vitamin-szint és a betegség súlyossága közötti kapcsolat vizsgálata herediter angioödémában." Orvosi Hetilap 160, no. 25 (2019): 987–93. http://dx.doi.org/10.1556/650.2019.31429.

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Abstract: Introduction: In recent years, many papers analyzed the relationship between serum vitamin D3 level and the frequency and activity of various diseases at least partially attributed to immune mechanisms. Aim: We looked for correlations among the number and location of edematous episodes occurring in patients with hereditary angioedema due to C1-inhibitor deficiency (C1-INH-HAE) and the quantity of the C1-inhibitor used for supplementation as well as the vitamin D3 levels of patients. Method: We measured vitamin D3 levels in 118 of the 175 C1-INH-HAE patients of the National Angioedema

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Radojicic, Cristine, and John Anderson. "Hereditary angioedema with normal C1 esterase inhibitor: Current paradigms and clinical dilemmas." Allergy and Asthma Proceedings 45, no. 3 (2024): 147–57. http://dx.doi.org/10.2500/aap.2024.45.240010.

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Background: A diagnosis of hereditary angioedema (HAE) with normal C1 esterase inhibitor (HAE-nl-C1-INH) can be challenging and pharmacologic management is not well defined. Objective: The objective was to discuss practical considerations in the clinical management of HAE-nl-C1-INH by using illustrative clinical vignettes to highlight and/or address select challenges. Methods: This was a narrative review. Results: Symptoms of HAE-nl-C1-INH overlap with HAE types I and II; the heterogeneity of presentation and symptom burden are diagnostic challenges. A patient history, with particular attentio

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Kovacsovics, T., J. Tschopp, A. Kress, and H. Isliker. "Antibody-independent activation of C1, the first component of complement, by cardiolipin." Journal of Immunology 135, no. 4 (1985): 2695–700. http://dx.doi.org/10.4049/jimmunol.135.4.2695.

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Abstract Lipid vesicles containing phospholipids known to be present in substantial amounts in mitochondrial membranes were tested for their capacity to activate C1. Among them, only cardiolipin (CL) was highly efficient in C1 activation; no such effect was observed with phosphatidylcholine, phosphatidylethanolamine, or phosphatidylinositol. CL was shown to bind specifically C1q, because only unlabeled C1q competed with 125I-C1q for binding to CL. The requirement for C1q was confirmed by the finding that only fully reconstituted macromolecular C1, containing C1q, was activated by CL. The speci

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Domańska, Anna. "Poziom efektywnej biegłości użytkowej – kto mierzy się z poziomem C1 na państwowym egzaminie certyfikatowym z języka polskiego jako obcego?" Poradnik Językowy 2020, no. 3/2020(772) (2020): 60–68. http://dx.doi.org/10.33896/porj.2020.3.4.

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The 11th examination session for foreigners taking the state examination in Polish as a foreign language at four levels (B1–C1) was held at the University of Warsaw in autumn 2019. The group taking the examination at the level of effective operational profi ciency (C1) were subject to a survey. The paper describes its selected aspects, such as age, gender, education, nationality, and motivations of the examinees. The results of the examined foreigners’ selfassessment were compared to the results they achieved in individual language skills. The motives for taking the examination were discussed

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Vega-Abarzúa, Jessica, Marco Morales, Constanza Olivo, Francisca Rubilar, and Eduardo Gutiérrez-Turner. "Preservice Teachers’ Perceptions of C1 English Proficiency in a Chilean Teacher Education Program." Profile: Issues in Teachers' Professional Development 27, no. 1 (2025): 133–50. https://doi.org/10.15446/profile.v27n1.115643.

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This mixed-methods study examined preservice teachers’ perceptions of C1 English proficiency, focusing on their linguistic competence, understanding, attitudes, and challenges. Conducted at a university in Ñuble, Chile, with 13 participants, data were gathered through a closed-ended questionnaire and a semi-structured interview. Findings suggest that perceived linguistic competence improves as students advance academically. Although participants’ understanding of the C1 level was often fragmented, they acknowledged the difficulty of achieving it and the importance of mastering grammar by gradu

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Chia, Stephen K. L., Nadia Solovieff, Mukta Joshi, et al. "On-treatment (tx) dynamic circulating tumor DNA changes (∆ctDNA) associated with progression-free survival (PFS) and overall survival (OS) of patients (pts) with HR+/HER2− advanced breast cancer (ABC) in MONALEESA-3 (ML-3)." Journal of Clinical Oncology 42, no. 16_suppl (2024): 1012. http://dx.doi.org/10.1200/jco.2024.42.16_suppl.1012.

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1012 Background: In ML-3, ribociclib (RIB) demonstrated a significant PFS/OS benefit over placebo (PBO) in pts with HR+/HER2− ABC. We report associations of on-tx ∆ctDNA with OS/PFS and tumor size and of ctDNA detectability with radiological progression. Methods: Pts were randomized 2:1 to RIB or PBO + fulvestrant as 1st- or 2nd-line tx. ctDNA levels were measured by NGS at cycle 1 day 1 (C1D1), C4D1, C8D1, and every 8 cycles until end of tx. Analyses included: Wilcoxon rank sum text to compare ∆ctDNA from C1D1 to C4D1; Kaplan-Meier method to visualize relationship of ctDNA with PFS/OS; Cox pr

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Marcisz-Grzanka, Katarzyna, Małgorzata Fuksiewicz, Beata Urszula Kotowicz та ін. "IL-1β and IL-6 as predictors of ypN and early response to neoadjuvant chemotherapy in patients with locally advanced GC and GEJ cancer." Journal of Clinical Oncology 41, № 4_suppl (2023): 454. http://dx.doi.org/10.1200/jco.2023.41.4_suppl.454.

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454 Background: Perioperative chemotherapy remains a standard of care in locally advanced gastric cancer. About 10-15% patients do not respond to such therapy and there are currently no biomarkers which could be used to predict early response to the neoadjuvant treatment. Methods: This prospective biomarker study aimed at identification of serum biomarkers of early response to neoadjuvant chemotherapy. Here we report only the results for serum cytokine assessments. It was an academic, nonrandomized, prospective study, conducted in MSCNRIO. Between January 2018 and November 2019 we analysed 42

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Fomina, Daria S., Elena N. Bobrikova, and Sofia A. Serdotetskova. "Features of diagnostics and clinical approaches to case management of patients with hereditary angioedema without C1 esterase inhibitor deficiency. Analysis of the clinical case." Russian Journal of Allergy 17, no. 1 (2020): 58–65. http://dx.doi.org/10.36691/raj.2.020.17.1.006.

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This article describes the clinical, biochemical and genetic features of hereditary angioedema (HAE) with normal level and functional activity of C1 esterase inhibitor. The discussion includes pathogenesis, diagnostics and case management of patients with hereditary angioedema without C1 esterase inhibitor deficiency. The materials of few scientific sources about patients with HAE without C1 esterase inhibitor deficiency in stages and our own clinical case (the female patient of fertile age with a confirmed mutation associated with factor XII (Hageman) deficiency) was given. The article descri

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Fomina, Daria S., Elena N. Bobrikova, and Sofia A. Serdotetskova. "Features of diagnostics and clinical approaches to case management of patients with hereditary angioedema without C1 esterase inhibitor deficiency. Analysis of the clinical case." Russian Journal of Allergy 17, no. 1 (2020): 58–65. http://dx.doi.org/10.36691/raj.2020.17.1.006.

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This article describes the clinical, biochemical and genetic features of hereditary angioedema (HAE) with normal level and functional activity of C1 esterase inhibitor. The discussion includes pathogenesis, diagnostics and case management of patients with hereditary angioedema without C1 esterase inhibitor deficiency. The materials of few scientific sources about patients with HAE without C1 esterase inhibitor deficiency in stages and our own clinical case (the female patient of fertile age with a confirmed mutation associated with factor XII (Hageman) deficiency) was given. The article descri

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Gorbunov, N. P., A. V. Zhakhov, I. N. Gorbunova, et al. "Quantification of C1 esterase inhibitor in human serum by enzyme-linked immunosorbent assay: Correlation with turbidimetric immunoassay." Medical Immunology (Russia) 25, no. 5 (2023): 1197–204. http://dx.doi.org/10.15789/1563-0625-qoc-2794.

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C1 inhibitor of serine proteases (C1-INH) performs a regulatory function in the complement system and vascular permeability. Deficiency of C1-INH leads to various forms of angioedema, including hereditary angioedema (HAE). The cause of HAE is a genetically determined violation of the synthesis of C1-INH. A decrease in the level of C1-INH to 50% relative to the norm leads to an increase in the production of bradykinin, which is the basis for the diagnosis of HAE. The development of affordable ELISA for the quantitative determination of C1-INH is a popular direction for clinicians. During the de

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Hayek, Salim M. "Occipital Neurostimulation-Induced Muscle Spasms: Implications for Lead Placement." September 2009 5;12, no. 5;9 (2009): 867–76. http://dx.doi.org/10.36076/ppj.2009/12/867.

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Background: For many headache types, occipital peripheral nerve stimulation (ONS) provides significant relief of chronic, frequent, and severe headaches. Though rarely reported, ONS may cause painful muscle spasms that make stimulator use impractical. The classic description of the technique advocates placement of the leads transversely at the level of the arch of C1 or at C1-2. At that level, the greater occipital nerve (GON) infrequently pierces the superficial fascia of the neck muscles to become superficial. However, important anatomic variability exists. Objective: To report placement of

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Coppola, Ludovico, Salvatore Guastafierro, Giovanni Verrazzo, Antonino Coppola, Domenico De Lucia, and Angelo Tirelli. "C1 Inhibitor Infusion Modifies Platelet Activity in Hereditary Angioedema Patients." Archives of Pathology & Laboratory Medicine 126, no. 7 (2002): 842–45. http://dx.doi.org/10.5858/2002-126-0842-ciimpa.

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Abstract Context.—C1 inhibitor (C1-INH) is an α2-globulin that blocks esterolytic activity of the first component of the classic complement cascade. The α-granules of normal human platelets also contain C1-INH, which is expressed on the platelet surface during platelet secretion in healthy patients, but it is clearly reduced in patients with hereditary angioedema (HAE). Objective.—To evaluate the effects of in vivo C1-INH concentrate infusion on platelet responsiveness and coagulation system activity in patients with HAE. Design.—Assessment of the platelet activity and plasma levels of C1-INH,

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Okroj, Marcin, Jonatan Sjölander, Leticia Corrales та Anna M. Blom. "Inter alpha inhibitor (IαI) inhibits classical complement pathway at C1 level". Molecular Immunology 46, № 14 (2009): 2860. http://dx.doi.org/10.1016/j.molimm.2009.05.303.

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M.Kes, Sufitni, Lita Feriyawati, Yunita Sari Pane, and Aznan Lelo. "The Effect of Torbangun Leaves Tea on Msg-induced Fetal Develop-ment Disorder in Mice." Sumatera Medical Journal 2, no. 1 (2019): 34–38. http://dx.doi.org/10.32734/sumej.v2i1.717.

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The safety of MSG on the fetus has not been confirmed yet. The objective of this research is to determine the effect of tea of torbangun leaves on fetal development disorder of mice. The present study is experimental with a Completely Randomized Design (CRD). Data obtained were then analyzed by ANOVA, with p<0,05 as the level of significant. The comparison of mean values ± SEM increase number of live fetuses group C1-T1 (4,60 ± 0,93; 11,40 ± 0,87), p=0,018. The comparison of mean values ± SEM decrease number of embryo re-sorption percentage group C0-C1 (00,00 ± 00,00; 36,74 ± 15,13), group

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Aronen, H. J., L. Kivisaari, I. Torstila, et al. "Level of Plasma Prekallikrein and its Inhibitors in Reactors and Nonreactors during Intravenous Enhancement with Contrast Media." Acta Radiologica 33, no. 4 (1992): 374–78. http://dx.doi.org/10.1177/028418519203300418.

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Complex contact activation systems may play a major role in the side effects of i.v. contrast media (CM). This is why quantitative measurements of several factors (plasma prekallikrein, hematocrit (hct), α-2-macroglobulin, α-1-antitrypsin, and C1-esterase inhibitor) were determined prior to and following the injection of CM during body CT examination in 5 patient groups, each (n = 10) receiving one of 5 different CM, including ioxaglate, meglumine iodamide, metrizamide, iohexol, and meglumine diatrizoate. The initial plasma prekallikrein level was available from 45 patients and was statistical

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Spajić, Marija, and Yvonne Vrhovac. "Common European Framework of Reference for Languages in Croatia: an analysis of writing competence at level C1." Linguistica 54, no. 1 (2014): 129–52. http://dx.doi.org/10.4312/linguistica.54.1.129-152.

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The aim of the article is to present the results of a research conducted with advanced (C1 level) learners of French as a foreign language in Croatia, in which their writing competence was studied according to the CEFR descriptors. Our hypothesis was that reaching level C1 demanded that a considerable amount of effort be invested in the development of learners’ writing and pragmatic skills. In the evaluation of these skills, characteristics of culture-specific learning contexts are to be taken into account. To test our hypothesis, we used a structured questionnaire and interviews with teachers

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Sitzman, Thomas J., Jessica L. Chee-Williams, Taylor D. Snodgrass, et al. "Creating a Superiorly Based Pharyngeal Flap: Is Prominence of C1 Superior Enough, and Will Adenoid Pad Be in the Way?" Plastic and Reconstructive Surgery - Global Open 13, no. 6 (2025): e6797. https://doi.org/10.1097/gox.0000000000006797.

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Background: Positioning the pharyngeal flap base high along the posterior pharyngeal wall is essential for optimizing speech outcomes. Objective data on where to place the flap base are lacking. Further, adenoid tissue can restrict cephalad positioning of the flap. This study aimed to improve the design of the pharyngeal flap by measuring the distance from the first cervical vertebrae (C1) to the palatal plane, and the adenoid depth in children undergoing evaluation for velopharyngeal insufficiency. Methods: This retrospective cross-sectional study analyzed magnetic resonance imaging (MRI) sca

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Kitsukawa, Kaoru, Takaaki Hirano, Hisateru Niki, Natsuki Tachizawa, and Hidefumi Mimura. "The Diagnostic Accuracy of MRI to Evaluate Acute Lisfranc Joint Injuries: Comparison With Direct Operative Observations." Foot & Ankle Orthopaedics 7, no. 1 (2022): 247301142110690. http://dx.doi.org/10.1177/24730114211069080.

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Background: Early diagnosis is important in patients with Lisfranc joint injury to avoid subsequent complications. As the ligaments in the Lisfranc joint are relatively small and course obliquely, isotropic 3-dimensional (3D) magnetic resonance imaging (MRI) can be beneficial to evaluate ligament injury. The purpose of this study was to investigate the diagnostic accuracy of MRI, including isotropic 3D MRI for acute injury of the Lisfranc joint, especially of the interosseous C1-M2 ligament (Lisfranc ligament), the dorsal C1-M2 ligament (dorsal ligament), and the interosseous C1-C2 ligament, c

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Liang, Ce, Teng Zhang, Yuan Cheng, and Lian Qiao. "Zingiberensis Newsaponin Targets Aldo-Keto Reductase Family 1 Member C1 to Suppress Malignant Phenotype of Gastric Cancer." Current Topics in Nutraceutical Research 22, no. 1 (2023): 23–31. http://dx.doi.org/10.37290/ctnr2641-452x.22:23-31.

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The purpose of the present research was to understand the mechanisms underlying the development of gastric cancer, with the goal of developing effective targets for treating gastric cancer. The expression level of aldo-keto reductase family 1 member C1 in gastric cancer tissues or gastric cancer cell lines by reverse transcription-polymerase chain reaction and western blotting shows a clear elevation. However, reducing aldo-keto reductase family 1 member C1 gene expression by knockdown methods led to the prevention of malignant behaviors of gastric cancer, such as proliferation, migration, inv

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Zhdanova, S. I., Z. M. Bikmullina, L. V. Kozlov, et al. "Complement system d-inhibitor at newborns of intrauterine infection development risk group." Genes & Cells 9, no. 3 (2014): 191–94. http://dx.doi.org/10.23868/gc120293.

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Complement system is considered as unspecific defence system of human organism, which starts to function just after born. The state of complement system at newborns including C1 inhibitor data is less studied. The paper is aimed to study functional activity and contents of C1 inhibitor in blood of newborn infants (taken on 3-5 day of life), their mothers and umbilical blood as well from group of the risk of development of mycoplasma and ureaplasma infections. Totally 105 blood samples taken from newborn infants and their mothers of risk group were analysed based on occasional selection approac

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Junior, Messias Gonçalves Pacheco, Nicoly Augusta da Silva Quezada dos Santos, Raphael Tavares Ribeiro, Jose Alberto Landeiro, and Bruno Lima Pessoa. "Hypoplasia of C1’s posterior arch: Is there an ideal anatomical classification?" Surgical Neurology International 12 (December 20, 2021): 623. http://dx.doi.org/10.25259/sni_820_2021.

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Background: Congenital anomalies of the atlas are rare and usually occur in conjunction with other congenital variants. They include a wide spectrum of anomalies ranging from clefts to hypoplasia or aplasia of its arches that may contribute to spinal cord compressive syndrome. Case Description: A 54-year-old male presented with the sudden onset of a severe quadriparesis and loss of proprioception after a minor fall. The magnetic resonance (MR) scan showed cord compression at the C1 level attributed to C1 arch hypoplasia. Two months following a decompressive C1 laminectomy without fusion, and t

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Mita, Dira Oktia, Ringki Agustinsa, and Edi Susanto. "Cognitive Level Analysis of Problems in Mathematics Textbook Class XII Revision 2018 Materials of Congress and Construction Based on the Revised Bloom Taxonomy." Journal of Education and Learning Mathematics Research (JELMaR) 2, no. 2 (2021): 14–25. http://dx.doi.org/10.37303/jelmar.v2i2.56.

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Abstract:This study aims to describe the distribution of cognitive levels of questions in the 2018 Revised Class XII Mathematics Textbook for Congruence and Similarity Based on Bloom's Taxonomy. Bloom's Taxonomy used is a revised Bloom's Taxonomy with cognitive process dimensions consisting of: remembering(C1), understanding(C2), applying(C3), analyzing(C4), evaluating(C5), and creating(C6). This type of research was descriptive research with a qualitative approach. Sources of data in this study were questions about the material congruence, similarity and competency test questions contained in

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Fu, Lisa W., Tamlyn Freedman-Kalchman, Stephen Betschel, and Gordon Sussman. "Review of hereditary angioedema." LymphoSign Journal 3, no. 2 (2016): 47–53. http://dx.doi.org/10.14785/lymphosign-2016-0001.

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Hereditary angioedema (HAE) is a rare disease caused by deficiency of C1 esterase inhibitor (C1-INH). It is an autosomal dominant disease caused by a variety of mutations in the C1-INH gene. C1-INH is an important regulator of several pathways. One pathway it affects is the kallikrein–kinin pathway, which results in the generation of bradykinin. Bradykinin is an important mediator of edema. Diagnosis is based on low levels of C1-INH. HAE with normal C1-INH is also recognized in the literature and the pathophysiology is due to another aspect of the pathway being affected leading to increased br

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Jacquemin, Marc, Abdellah Benhida, Kathelijne Peerlinck, et al. "A human antibody directed to the factor VIII C1 domain inhibits factor VIII cofactor activity and binding to von Willebrand factor." Blood 95, no. 1 (2000): 156–63. http://dx.doi.org/10.1182/blood.v95.1.156.

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Abstract The occurrence of factor VIII (fVIII) inhibitory antibodies is a rare complication of fVIII substitution therapy in mild/moderate hemophilia A patients. fVIII mutations in certain regions such as the C1 domain are, however, more frequently associated with inhibitor, for reasons which remain unclear. To determine whether inhibitors could map to the mutation site, we analyzed at the clonal level the immune response of such a patient with an inhibitor to wild-type but not self-fVIII and an Arg2150His substitution in the C1 domain. Immortalization of the patient B lymphocytes provided a c

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Jacquemin, Marc, Abdellah Benhida, Kathelijne Peerlinck, et al. "A human antibody directed to the factor VIII C1 domain inhibits factor VIII cofactor activity and binding to von Willebrand factor." Blood 95, no. 1 (2000): 156–63. http://dx.doi.org/10.1182/blood.v95.1.156.001k50_156_163.

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The occurrence of factor VIII (fVIII) inhibitory antibodies is a rare complication of fVIII substitution therapy in mild/moderate hemophilia A patients. fVIII mutations in certain regions such as the C1 domain are, however, more frequently associated with inhibitor, for reasons which remain unclear. To determine whether inhibitors could map to the mutation site, we analyzed at the clonal level the immune response of such a patient with an inhibitor to wild-type but not self-fVIII and an Arg2150His substitution in the C1 domain. Immortalization of the patient B lymphocytes provided a cell line

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Madden, Christopher J., Sean D. Stocker, and Alan F. Sved. "Attenuation of homeostatic responses to hypotension and glucoprivation after destruction of catecholaminergic rostral ventrolateral medulla neurons." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 291, no. 3 (2006): R751—R759. http://dx.doi.org/10.1152/ajpregu.00800.2005.

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This study determined the effect of destruction of rostral ventrolateral medulla (RVLM)-C1 cells on integrated sympathetic and hormonal responses to hypotension or glucoprivation. Injection of anti-dopamine β-hydroxylase-saporin into the RVLM resulted in 29–99% depletion of RVLM-C1 neurons and ∼60% reduction in the number of A5 neurons. As in our previous study in unanesthetized rats, resting mean arterial pressure (MAP) was reduced by ∼10 mmHg in rats with >80% depletion of RVLM-C1 cells compared with control rats, although resting heart rate (HR) did not differ significantly. In the prese

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Hong, Yang, Elizabeth Fink, Qiong-Ying Hu, William B. Kiosses, and John H. Elder. "OrfA Downregulates Feline Immunodeficiency Virus Primary Receptor CD134 on the Host Cell Surface and Is Important in Viral Infection." Journal of Virology 84, no. 14 (2010): 7225–32. http://dx.doi.org/10.1128/jvi.00434-10.

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ABSTRACT Feline immunodeficiency virus (FIV) OrfA is an accessory protein that is critical for productive viral replication and infection in T cells. Here, we show that OrfA acts to markedly reduce cell surface expression of the FIV primary binding receptor. Downregulation does not occur at the transcriptional or translational level in that the amounts of CD134 mRNA and protein in total cell lysates are not altered between parental 104-C1 T cells and the same cell line stably expressing OrfA (104-C1-OrfA). Analysis by confocal microscopy revealed significant accumulation of CD134 in the Golgi

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Burak, Kelly W., and Gary R. May. "C1 Inhibitor Deficiency and Angioedema of the Small Intestine Masquerading as Crohn’s Disease." Canadian Journal of Gastroenterology 14, no. 4 (2000): 349–51. http://dx.doi.org/10.1155/2000/414107.

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A case of C1 inhibitor deficiency presenting as localized edema of the small intestine is described. A 16-year-old, previously healthy woman presented with recurrent attacks of abdominal pain and vomiting following minor abdominal trauma. Investigations including computed tomography scan and barium studies confirmed localized edema of the jejunum. At laparoscopy, Crohn’s disease was suspected; however, a subsequent enteroscopy was normal. Complement levels revealed a low C4 level, and C1 inhibitor deficiency was later confirmed. Attacks of abdominal pain began after starting oral contraceptive

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