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Dissertations / Theses on the topic 'C2-symmetric'

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Published: 4 June 2021

Last updated: 1 February 2022

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1

Grainger, Richard Sheridan. "Cycloaddition reactions of C2-symmetric vinyl sulfoxides." Thesis, University of Sheffield, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.387754.

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2

Sibbons, Kevin F. "Synthesis and application of C2-Symmetric Azamacrocyclic Ligands." Thesis, Queen Mary, University of London, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.509663.

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3

Soltan, Omar. "Solution isomerization of commercial C2-symmetric metallocene catalysts." Thesis, Stellenbosch : University of Stellenbosch, 2006. http://hdl.handle.net/10019.1/2856.

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Thesis (MSc (Chemistry and Polymer Science))--University of Stellenbosch, 2006.<br>This study concerns the investigation of the isomerization of different metallocene catalysts in solution, and the effects thereof on the microstructure of polypropylenes prepared with these catalysts. Two C2 symmetric ansa metallocenes, ethylene-bis(indenyl) zirconium dichloride (EI) and dimethylsilyl-bis(2-methyl benzoindenyl) zirconium dichloride (MBI) were exposed, in solution, to both sunlight and UV radiation. The rac-meso isomerization of these catalysts were followed by 1H NMR spectroscopy. The re

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4

Lake, Fredrik. "C2- and C3-symmetric ligands via ring-opening of aziridines." Doctoral thesis, KTH, Chemistry, 2002. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-3424.

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<p>This thesis deals with the design and synthesis of chiralenantiopure nitrogencontaining ligands and the use of theseligands in asymmetric catalysis. A modular synthetic approachto enantiopure nitrogen-containing ligands was developed. Thesynthetic method is based on the ring-opening of activatedchiral aziridines by nitrogen nucleophiles. The aziridines areconveniently prepared from amino alcohols. The structure oftheaziridine and of the nucleophile can be extensively varied andlibraries of ligands are easily prepared. The use of primaryamines affords C<sub>2</sub>-symmetric bis(sulfonamides

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5

Luo, Yunfei. "Chemoenzymatic synthesis of C2 symmetric chiral dienes for asymmetric catalysis." Thesis, University of Liverpool, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.539483.

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6

Tse, Eric Sing Yuen. "Synthesis and Applications of C2-Symmetric Ethers and Related Compounds." Thesis, Imperial College London, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.511864.

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7

Long, Sihui. "PEPTIDOMIMICRY: DESIGN, SYNTHESIS AND CONFORMATIONAL STUDY OF C2-SYMMETRIC OLIGOUREAS." UKnowledge, 2006. http://uknowledge.uky.edu/gradschool_diss/295.

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Mimicking the structure and even the function of an ??-peptide with artificial chainmolecules such as ??-peptides, ??-peptides and other unnatural oligomers has shown early success.The structural similarities between natural peptides and oligoureas lead to the belief that C2-symmetric oligoureas could be a good candidate for peptidomimicry. Molecular modelingindicates that both homochiral (all monomers have the same absolute configuration) andalternate chiral (absolute configuration of the residues alternate) C2-symmetric oligoureas canform helix- and sheet-like structures in solution conditio

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8

Marshall, Colin. "The synthesis of chiral C2-symmetric N-heterocyclic carbene complexes." Thesis, University of Aberdeen, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.248633.

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The quaternisation of 1-substituted-azoles with a, w-dihaloalkanes furnished the diazolium salts. Conversion of the salts by deprotonation in the presence of sulphur generated the corresponding dithiones. A series of propylene diimidazolium salts and thiones gave an insight into the ease of handling, hygroscopic nature and yields associated with these compound. Propylene bridged diimidazol-2-ylidenes and ethylene bridged imidazolidin-2-ylidenes were never isolated from deprotonation of the salts or reductive desulphurisation of the thiones. <i>In situ</i> reactions with the salts and palladium

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9

Rife, Nathan Prentice. "Tacticity control of polypropylene using a C2-symmetric family of catalysts." Texas A&M University, 2007. http://hdl.handle.net/1969.1/85795.

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A family of C2-symmetric catalysts was designed and synthesized with the intent to polymerize propylene. The catalyst was designed to be C2-symmetric for the specific goal that the catalyst would have two identical sites for the propagation of the polymer and therefore eliminate some of the stereoerrors that occur in the propagation of the polymer chain. This catalyst would also operate under simple enantiomorphic site control and therefore the insertion of the monomer would be governed by the ligand surrounding the active site. The ligands were synthesized with increasing degrees of steric bu

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10

Rémy, Pauline. "New C1- and C2-symmetric sulfoximines synthesis and application in enantioselective metal catalysis /." [S.l.] : [s.n.], 2006. http://deposit.ddb.de/cgi-bin/dokserv?idn=981071929.

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11

Al-Bahily, Khalid A. "Design and synthesis of new C1 and C2-symmetric ansa-metallocene catalysts for isotactic-polypropylene formation." Texas A&M University, 2004. http://hdl.handle.net/1969.1/3061.

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Several ansa C1-symmetric cyclopentadienyl-fluorenyl metallocenes based on zirconium have been prepared with different substituents at position 3 on the cyclopentadienyl ring. Isotactic polypropylene production from these systems depends highly on the size of these substituents. Therefore, large groups such as 1-methyl-4-tbutylcyclohexyl (metallocene 6), 1-methyl-cyclohexyl (metallocene 7), 1,3,3,5- tetramethylcyclohexyl (metallocene 8), and 2,3,4-trimethyl-3-pentyl (metallocene 9) have been investigated. In combination with methylaluminoxane (MAO), they showed good activity and produced high

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12

Amer, Ismael. "An investigation of the effect of chain length on stereo-regulation with C2 symmetric metallocene catalysts." Thesis, Stellenbosch : University of Stellenbosch, 2006. http://hdl.handle.net/10019.1/3003.

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Thesis (MSc (Chemistry and Polymer Science))--University of Stellenbosch, 2006.<br>This study concerns the polymerization of propylene both in the presence and absence of molecular hydrogen. The percentage of hydrogen used as a terminating agent in the polymerization reactions was varied from 0.1 wt% to 15.0 wt% in order to compare a variety of polymers with different percentages of hydrogen incorporated. Two ansa metallocene catalysts were used: (A) rac-[ethylene bis(indenyl)] zirconium dichloride (rac-Et(Ind)2ZrCl2) and (B) dimethylsilyl-bis(2-methyl benzoindenyl) zirconium dichloride

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13

Rigotti, Thomas. "Synthesis and metal complexes of C2 symmetric ligands obtained from (R)-(+)-Betti and dialdehydes for asymmetric induction reactions." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2015. http://amslaurea.unibo.it/9335/.

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The aim of this master’s research thesis was the employment of an enantiopure 1,3-aminoalcohol, the 1-(α-aminobenzyl)-2-naphthol, known as Betti base, for the synthesis of some novel compounds which show a C2 symmetry. Some of these compounds, after derivatization, were used as ligands in association with transition metals to prepare some catalysts for enantioselective catalytic reactions. Some aminoalcohol (Salan-type) derivatives of these compounds were obtained upon reduction and in some cases it was possible to obtain complexes with transition metals such as Mn, Ni, Co and Cu. Furthermore

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14

Otomaru, Yusuke. "Preparation of new C2-symmetric chiral diene ligands and their use for rhodium-catalyzed asymmetric addition of organoboron reagents." 京都大学 (Kyoto University), 2005. http://hdl.handle.net/2433/144596.

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15

Kameda, Minoru. "Molecular design of N-spiro C2-symmetric chiral phase-transfer catalysts for practical asymmetric synthesis of α-amino acids". 京都大学 (Kyoto University), 2004. http://hdl.handle.net/2433/147838.

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16

Turkmen, Yunus Emre. "Novel Studies On The Chemoenzymatic Synthesis Of Polychlorinated Bicyclic Systems And The Synthesis Of C2 And C3 Symmetric Chiral Ligands." Master's thesis, METU, 2006. http://etd.lib.metu.edu.tr/upload/3/12607340/index.pdf.

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Optically active polychlorinated bicyclic systems are important starting materials for the synthesis of complex target molecules. In the first part of the study, the syntheses of several racemic and meso hexachloronorbornene derivatives were executed successfully, starting from hexachlorocyclopentadiene. The enantio-enriched acetoxymethyl derivative (-)-2 and the hemiester (-)-6 were synthesized in high e.e. values by using several hydrolase type enzymes. The absolute configuration of (-)-2 was determined by transforming it to the corresponding norbornene derivative (-)-7 with known absolut

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17

Wannberg, Johan. "Microwave-Assisted Synthesis of C2-Symmetric HIV-1 Protease Inhibitors : Development and Applications of In Situ Carbonylations and other Palladium(0)-Catalyzed Reactions." Doctoral thesis, Uppsala universitet, Avdelningen för organisk farmaceutisk kemi, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5804.

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The HIV protease is an essential enzyme for HIV replication and constitutes an important target in the treatment of HIV/AIDS. Efficient combination therapies using inhibitors of the reverse transcriptase and protease enzymes have led many to reevaluate HIV infections from a terminal condition to a chronic-but-manageable disease in the developed world. Unfortunately, the emergence of drug resistant viral strains and severe treatment-related adverse effects limit the benefits of current anti-HIV/AIDS drugs for many patients. Furthermore, less than one in ten patients infected with HIV in low- an

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18

Mohammad, Adil. "Achiral and chiral, C2-symmetric bicyclic guanidinates based on 1,5,7-triazabicyclo[4.4.0.]dec-5-ene as ligands in high- and mid-valent early transition metal chemistry." Diss., University of Iowa, 2010. https://ir.uiowa.edu/etd/714.

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The syntheses of achiral and chiral, C2-symmetric bicyclic guanidine derivatives of 1,5,7-triazabicylo[4.4.0]dec-5-ene (hppH) are described. Quantum mechanical MO calculations based on Spartan were performed in order to study the effects (electronic and steric) of substituents on the basicity of hppH derivatives. These calculations showed that substituting only one methyl group on each carbon next to the bridgehead nitrogen of hppH gives high basicity. Based on these calculations, syntheses of achiral (hpp*H, with four methyl groups) and chiral C2-symmetric (hpp'H, with two methyl groups) deri

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19

Perkins, Jonathan Clarence. "Synthesis of [2.2.2]-Diazabicyclic Alkaloids: I: Diels-Alder Reactions of a C2-Carboxy Pyrazinone & Ii: Intermolecular Diels-Alder Reaction of a Proline Derived Pyrazinone with Symmetric Dienophiles." W&M ScholarWorks, 2017. https://scholarworks.wm.edu/etd/1516639679.

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[2.2.2]-Diazabicyclic alkaloids are a natural product family with diverse biological activities. The development of a synthetic methods towards the synthesis of [2.2.2]-diazabicyclic alkaloids is described. I: Diels-Alder Reactions of a C2-Carboxy Pyrazinone Using an N-heterocyclic carbene catalyzed aroylation of a proline 3,5-dichloropyrazinone, a synthetic route to C2-carboxy pyrazinones was developed to study the intermolecular and intramolecular Diels-Alder reactions of these compounds to form the bicyclo[2.2.2]diazaoctane core. Studies showed that having oxidation present α to the pyrazi

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20

Böhnisch, Torben [Verfasser], Franc [Akademischer Betreuer] [Gutachter] Meyer, Guido [Gutachter] Clever, et al. "C2-Symmetric Pyrazole-Bridged Ligands and Their Application in Asymmetric Transition-Metal Catalysis / Torben Böhnisch. Betreuer: Franc Meyer. Gutachter: Franc Meyer ; Guido Clever ; Thomas Waitz ; Ulf Diederichsen ; Dietmar Stalke ; Konrad Koszinowski." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2016. http://d-nb.info/1103233963/34.

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21

Gillespie, Jason A. "Design and synthesis of wide bite angle phosphacyclic ligands." Thesis, University of St Andrews, 2012. http://hdl.handle.net/10023/3100.

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By examining structure activity relationships for a given catalytic reaction it is possible to discover what ligand features and parameters lead to stable and highly active/selective catalyst systems. With this knowledge in hand it may be possible to rationally design next generation ligands and catalysts to affect improved substrate transformations, with higher selectivities and faster reaction times. The success of Burk's DuPhos ligands in asymmetric hydrogenation demonstrated that chiral phosphacycles can be a potent source of chiral induction, whilst in a similar vein the work of van Leeuw

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22

Wannberg, Johan. "Microwave-Assisted Synthesis of C₂-Symmetric HIV-1 Protease Inhibitors : Development and Applications of In Situ Carbonylations and other Palladium(0)-Catalyzed Reactions." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5804.

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23

HONG, BAO-CHUN, and 洪寶春. "Studies on laticyclic polyenes:synthesis of Cs-and C2 -symmetric hexacycloecosatetraendiones." Thesis, 1991. http://ndltd.ncl.edu.tw/handle/67965450241554773421.

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24

Panosyan, Francis Bartholomew. "Asymmetric reduction using C2-symmetric metal complexes : the first autocatalytic asymmetric reduction." 2004. http://link.library.utoronto.ca/eir/EIRdetail.cfm?Resources__ID=232669&T=F.

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25

羅柏翔. "Asymmetric Henry Reaction Catalyzed by Cu(I)/Camphorsulfonamide derived C2-symmetric chiral." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/32459121125100891749.

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26

HUNG, HSU-HENG, and 洪旭亨. "The Preparation and Mesophase Studying of C2 Symmetric Hexa-peri-hexabenzocoronenes Derivatives." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/08084716641947729430.

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碩士<br>國立高雄師範大學<br>化學系<br>104<br>In this thesis, we present a series of different mono-substituted functionalized hexa-benzocoronene (HBC) drivatives carrying five alkyl chains. Using the Sonogashira coupling reaction, 1-ethynyl-4-alkylbenzene, 1-ethynyl-4-alkoxybenzene, and alkyl-4-ethynyl benzoate groups were intro- duced into mono-bromohexabenzocoronenes to obtain compounds 17-22. These compounds obtained were char- acterised by nuclear magnetic resonance spectrometer (NMR) 1H-NMR and 13C-NMR, ultraviolet-visible spectrophotomerter (UV-Vis), and matrix-assisted laser desorption/ ionization

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27

"Asymmetric catalysis with a C2-symmetric bisoxazolidine and enantioselective sensing using axially chiral diacridylnaphthalenes." GEORGETOWN UNIVERSITY, 2009. http://pqdtopen.proquest.com/#viewpdf?dispub=3339924.

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28

Rémy, Pauline [Verfasser]. "New C1- and C2-symmetric sulfoximines : synthesis and application in enantioselective metal catalysis / vorgelegt von Pauline Rémy." 2006. http://d-nb.info/981071929/34.

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29

Byers, Jeffery Allen. "Synthetic and mechanistic studies into the kinetic resolution of alpha-olefins using C1- and C2- symmetric zirconocene polymerization catalysts." Thesis, 2007. https://thesis.library.caltech.edu/1839/5/swivelfrit.mov.

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Mechanistic and synthetic investigations into the kinetic resolution of racemic alpha-olefins by polymerization catalysis using C1- and C2-symmetric zirconocenes are reported. The importance of chain end control as a stereocontrol element was probed with ethylene and propylene copolymerizations catalyzed by the C1-symmetric catalyst, {1,2-(SiMe2)2(eta-5-3,5-C5H1(CHMe2)2)(eta-5-4-C5H2((S)-CHMeCMe3)]}ZrCl2/MAO. Selectivity factors and pentad analysis of racemic alpha-olefin and propylene polymerizations catalyzed by a similar C1-symmetric catalyst, {1,2-(SiMe2)2(eta-5-3,5-C5H1(CHMe2)2)(eta-5-4

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30

Shao, Yi-Ming. "Design, Synthesis, Biological Activity, and Complexed Structure of SARS-CoV 3CL Protease Inhibitors: (i) Trifluoromethyl Ketones and (ii) C2-Symmetric Diols." 2006. http://www.cetd.com.tw/ec/thesisdetail.aspx?etdun=U0001-1106200616003800.

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31

Shao, Yi-Ming, and 邵奕鳴. "Design, Synthesis, Biological Activity, and Complexed Structure of SARS-CoV 3CL Protease Inhibitors:(i) Trifluoromethyl Ketones and (ii) C2-Symmetric Diols." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/65964005844513550816.

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碩士<br>國立臺灣大學<br>生化科學研究所<br>94<br>Severe acute respiratory syndrome (SARS) is a new viral infectious disease caused by a novel coronavirus (SARS-CoV). Currently, no effective antiviral agents exist against this type of virus. This thesis comprises the design, synthesis, biological activity, and complexed structures of two types of small molecules as inhibitors of SARS-CoV 3CL protease: (i) trifluoromethyl ketones and (ii) C2-symmetric diols. Trifluoromethyl ketones are known to be reversible inhibitors of some serine proteases, such as elastase and chymotrypsin. The best one of a series o

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32

Lin, jia-jeng, and 林家正. "1. Synthesis of C2-symmetric Chiral Ether2. To explore the chiral Ether-TiCl4-Mg-promoted asymmetric coupling of CHBr3 with ketone." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/7nrqrn.

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碩士<br>國立中興大學<br>化學系所<br>106<br>Usually chiral ethers have C2 symmetry and play an important role in asymmetric catalytic synthesis. So that we want to create chiral ligand contain C2 symmetry. We use THF as the target structure, Reference other people paper. Using glucosamine hydrochloride as starting material, and modify it to our finial material chiral ether. Our lad have published several papers about using TiCl4-Mg bimetallic complexes to induce aldehyde and ketone to conduct Methylation or 1, 2 addition with THF or DME, and the product is alcohol. In different rate of TiCl4 and Mg, have d

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33

Tripathi, Anil Kumar [Verfasser]. "Synthesis of N-amino compounds and C2 symmetric N-amino compounds and transformation into aziridines using olefins / vorgelegt von Anil Kumar Tripathi." 2008. http://d-nb.info/999174215/34.

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34

Chiang, Chien-Wei, and 江建緯. "C2-Symmetric Proline-Derivative Nickel Complexes for Mimicking the Functional Model of Nickel Superoxide Dismutase and Their Application for thia-Michael Addition." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/41634518463801219304.

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博士<br>國立臺灣師範大學<br>化學系<br>101<br>Nickel-containing superoxide dismutase (NiSOD), has been discovered recently from Streptomyces species and marine cyanobacteria. NiSOD can catalyze the dismutation of O2− into O2 and H2O2 through a cycle of Ni(II) and Ni(III) oxidation states. In order to mimic the fuction of the active site of the NiSOD, a series of pentadentate ligands equipped with pyridine and proline derivatives have been designed and prepared. The prepared ligand, for instance 2,6-bis(((S)-2-(diphenylhydroxymethyl)-1-pyrrolidinyl)methyl)pyridine (H2BDPP), was deprotonated and employed to r

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35

Wen, Shung-Shien, та 溫學賢. "(一) vanadium(IV) complex mediated in catalyze asymmetric Mukaiyama aldol addition reaction (二)Study of C2 symmetric 2,6-dioxabicycle[3,3,0]octane as chiral templet". Thesis, 1999. http://ndltd.ncl.edu.tw/handle/04931318409431181780.

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碩士<br>國立臺灣師範大學<br>化學研究所<br>87<br>Condensation of vanadyl sulfate with 2,2-biphenol in the presence of N-containing ligands provides oxovanadium complexes which serve as efficient catalysts in Mukaiyama aldol reactions to afford aldol products in 78-99% yields with diastereoselectivities of up to 91/9 (anti/syn)

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36

He, Cyuan-Fang, and 何權芳. "1.Synthesis of Single-Orientation C2-Symmetric Chiral Ether2.To Explore “The Chiral Ether-TiCl4-Mg” Promoted Asymmetric Coupling of Dichloromethane and Bromoform with Ketones." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/h9j8gx.

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碩士<br>國立中興大學<br>化學系所<br>107<br>In the first part,we wish report protocols whereby the synthesis of C2-symmetric chiral ether. There were several chiral ligand had been reported, and they all have the same C2-symmetric characteristic on their structure. Therefore we design a strategy to get the furan like structure of C2-symmetric chiral ether, followed by rearrangement and reduction reaction of D-glucosamine to get 2,5-anhydro-D-mannitol , then we can easily synthesis C2-symmetric chiral ether by functional group modification in few steps. In our second part, we wish to explore the effi

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37

Chang, Yuan-Kang, and 張元康. "A C2-Symmetric Chiral Pool Based Flexible Strategy: Concise Synthesis of COTC-Np, (+)-MK7607, (+)-Lycoricidine, (+)-Valienamine, Key Intermediate of (+)-Pancratistatin, and Conduramines A-1 and E." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/s87qbg.

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博士<br>國立中興大學<br>化學系所<br>98<br>英文摘要: Herein, we propose a novel, concise and flexible total synthesis of prominent and pioneer molecules belong to pseudo-carbasugar [COTC-Nap, (+)-MK7607] and aminocyclitol [(+)-Lycoricidine, (+)-Valienamine] families. Aforementioned compounds possess excellent biological activity such as antibiotic, antiviral, and glycosidase inhibitors and so on. Interestingly, all of our synthetic strategies utilized O-isopropylidene protected cyclohexenediol as key intermediate. Diastereoselective facile synthesis of key intermediate achieved from inexpensive L (or) D tarta

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38

Lo, Hong-Jay, and 駱宏杰. "A C2-Symmetric Chiral Pool Based Flexible Strategy: Concise Synthesis of (+)-Valienamine, (+)-Valiolamine, 1-epi-(+)-MK7607, 1-epi-(-)-Streptol, (-)-Hygromycin A, Conduramine B-1, C-1, C-4, D-1, F-1, and F-4, and Key Intermediate of (-)-Laminitol." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/kg5n6m.

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博士<br>國立中興大學<br>化學系所<br>100<br>Herein, we propose a facile and flexible synthetic strategy of chemically challenging and biologically important molecules from C2 symmetric inexpensive chiral pools [L (or) D Tartaric acid]. This expeditious total synthesis includes aminocyclitols [(+)-Valienamine & (+)-Valiolamine], pseudo-carbasugars [1-epi-(+)-MK7607, 1-epi-(-)-streptol], Conduramine series and (-)-Hygromycin A. Aforementioned compounds possess excellent biological activity, such as α- glucosidase inhibitors, antibiotics containing broad spectrum of activity such as peptidyl transferase inhib

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