Books on the topic 'C2f module'

This chapter illustrates use of (i) the score statistic and (ii) a goodness-of-fit statistic to test if an embedded model provides an adequate fit, in the latter case with critical values calculated by bootstrapping. Also illustrated is (iii) calculation of parameter confidence intervals and CDF confidence bands using both asymptotic theory and bootstrapping, and (iv) use of profile log-likelihood plots to display the form of the maximized log-likelihood and scatterplots for checking convergence to normality of estimated parameter distributions. Two different data sets are analysed. In the first, the generalized extreme value (GEVMin) distribution and its embedded model the simple extreme value (EVMin) are fitted to Kevlar-fibre breaking strength data. In the second sample, the four-parameter Burr XII distribution, its three-parameter embedded models, the GEVMin, Type II generalized logistic and Pareto and two-parameter embedded models, the EVMin and shifted exponential, are fitted to carbon-fibre strength data and compared.

Chapter 2 begins with a depiction of the evolutionary origins of CRF in living things. CRF appears to date back hundreds of millions of years. It is found in diverse invertebrates, including flies and bees. Invertebrates’ brains look nothing like those of vertebrates except for the diverse information molecules that underlie both brain systems. There is no clear anatomical organ like the HPA axis in invertebrates, yet information molecules, including CRF, are just as important to invertebrate functioning as they are to vertebrates. CRF in invertebrates is linked to basic regulatory functions such as osmotic regulation, food intake, learning, and circadian rhythmicity. There are many examples of regulatory molecules that, over time, become adapted to serve multiple functions. Once a gene for a potent regulatory molecule exists, the potential for the differentiation of function, regulation, and mode of action exist as well.

Un año después de haberse instaurado el Modelo COF en el Programa de Contaduría Pública de la Universidad Libre y habiendo publicado la 1ª Edición de esta obra en el año 2008, su desarrollo en las aulas indicó, entre otros elementos necesarios que fueron identificados en los procesos de autoevaluación permanente, que el modelo debía robustecerse incluyendo la estrategia de proyectos de aula. Fue necesario entonces, preparar y llevar a cabo la Segunda edición de la obra, la cual fue publicada en 2012 robustecida con las experiencias obtenidas durante los cuatro años que le antecedieron. Ahora, después de ocho años de haber sido publicada la segunda edición, se hace necesario actualizar esta obra mediante una Tercera Edición, en la que se plasman: nueva regulación tanto legal como institucional, el robustecimiento del modelo con la experiencia aplicada mediante el currículo planeado, una revisión de completitud al capítulo Proyecto de Aula, así como del currículo oculto o de contexto, todo lo cual obligó a revisar la estructura de la obra. En esta Tercera edición se incluyeron nuevos elementos teóricos que respaldan la pedagogía y la didáctica planteadas en el modelo, se hace referencia a una reforma al plan de estudios del programa académico que se encuentra en curso al momento de publicar esta obra, se fortalecer el discurso de la estrategia investigativa como eje transversal en los Planes de Aula, y, se hace referencia a los Lineamientos y Orientaciones para el aprendizaje de jóvenes y personas adultas, instrumento difundido por el Ministerio de Educación Nacional. Hay la certeza de que se ha avanzado por el camino correcto en la aplicación del modelo, porque el mismo ha sido exitosamente validado con trece años de desarrollo (2007-2019) en el Programa de Contaduría Pública de la Universidad Libre; ha sido bien ponderado en cuatro oportunidades por Pares académicos que en nombre del Ministerio de Educación Nacional han evaluado el programa de Contaduría Pública para acreditarlo en alta calidad. También lo han evaluado Pares extranjeros para expedir el Certificarlo Internacional de alta calidad. Por lo expuesto, el modelo se considera suficientemente validado. Es necesario destacar que un currículo es de actualización permanente debido a las cambiantes dinámicas sociales y las nuevas problemáticas que tales dinámicas generan en el campo de la educación superior. En este sentido, en 2014, la Universidad Libre realizó la actualización del Proyecto Educativo Institucional (PEI), incorporando el modelo Autoestructurante Cognoscente o Cognoscitivo (Acuerdo N° 04 de octubre de 2014, Honorable Consiliatura), cuyas teorías que lo integran y sustentan, ya venían siendo soporte epistemológico del modelo COF. Igualmente, en el año 2017

This chapter details the widely accepted standard approach to arterial spin labeling (ASL) acquisition and the associated analysis needed to extract an image of perfusion in the brain, also known as the cerebral blood flow (CBF). Starting with pairs of images with and without labeling, a perfusion-weighted image can be generated. With the addition of a calibration image, this can be converted to an absolute measure of perfusion. Following the recommendations of the community for ASL acquisition, this chapter outlines the main steps of subtraction, kinetic model inversion, and calibration required for analysis of ASL data.

Cardiac connective tissues are primarily formed by cardiac fibroblasts (CF) of diverse embryonic origins. Whereas CF specific roles in cardiac morphogenesis remain under-researched, their involvement in adult cardiac fibrosis is clinically relevant. Cardiac fibrosis is a common element of several chronic cardiac conditions characterized by the loss of ventricular wall mechanical function, ultimately driving to heart failure. In the ischaemic heart early reparative fibrosis evidences the very restricted regenerative potential of the myocardium. In non-ischaemic diseases fibrosis is activated by unknown signals. We summarize current knowledge on the origin of CFs and their developmental roles, and discuss the differential disease-dependent response of different CF subpopulations to various pathological stimuli. We also describe the characteristic cell-cell and cell-matrix interactions that determine the fibrotic remodelling of the myocardium. We analyse experimental models for the study of cardiac fibrosis, and suggest future directions in the search for new markers and therapeutic targets.

In 1996, Peter Lasersohn discovered a construction in which an if-clause appears as an NP-modifier, rather than a sentential adjunct (e.g. The price if you pay now is predictable). He dubbed these types of if-clauses “adnominal conditionals” (ACs). Building on Lasersohn’s proposal that ACs are NP modifiers, this chapter provides a compositional analysis of ACs within a restrictor-based analysis of conditionals (Lewis 1975; Kratzer 1986; Heim 1982). According to my proposal, ACs always restrict the domain of an operator within the NP they modify (a modal adjective), and when there is no overt operator within the NP, ACs restrict the domain of a covert necessity modal adjective (cf. Kratzer 1986’s analysis of matrix indicative conditionals).

This fourth edition provides an updated look at information organization, featuring coverage of the Semantic Web, linked data, and EAC-CPF; new metadata models such as IFLA-LRM and RiC; and new perspectives on RDA and its implementation. This latest edition ofThe Organization of Informationis a key resource for anyone in the beginning stages of their LIS career as well as longstanding professionals and paraprofessionals seeking accurate, clear, and up-to-date guidance on information organization activities across the discipline. The book begins with a historical look at information organization methods, covering libraries, archives, museums, and online settings. It then addresses the types of retrieval tools used throughout the discipline—catalogs, finding aids, indexes, bibliographies, and search engines—before describing the functionality of systems, explaining the basic principles of system design, and defining how they affect information organization. The principles and functionality of metadata is next, with coverage of the types, functions, tools, and models (particularly FRBR, IFLA-LRM, RDF) and how encoding works for use and sharing—for example, MARC, XML schemas, and linked data approaches. The latter portion of the resource describes specific activities related to the creation of metadata for resources. These chapters offer an overview of the major issues, challenges, and standards used in the information professions, addressing topics such as resource description (including standards found in RDA, DACS, and CCO), access points, authority control, subject analysis, controlled vocabularies—notably LCSH, MeSH, Sears, and AAT—and categorization systems such as DDC and LCC.

The EBA Guidelines on loan origination and monitoring (hereinafter "GL LOM") undoubtedly represent a substantially new piece of the banking regulatory framework. In fact, for the first time, the regulator moves into a topic that was traditionally outside the scope of financial regulation, so far almost exclusively focused on aspects directly linked to both micro- and macro-prudential stability, notably through capital and liquidity management requirements and guidelines on Business Model and Internal Governance. The credit management process, and in particular loan origination and monitoring, has always been typically considered as a business issue under sole responsibility of banks, as it is considered one of the "core" processes (if not the "core" process) of the banking business. As a matter of fact, since the issue of the capital requirement regulation (i.e., Basel II and Basel III), and the introduction of the use requirements for the rating systems, the regulator moved very close, but not yet, to prescribe specific credit assessment criteria, while dictating methodological and organizational requirements for the authorization of the rating systems, and leaving substantial freedom to banks to define their own models and embedded assessment criteria and indicators. With the GL LOM, the regulator takes a further step, remarkably beyond its traditional remit, dictating principles and rules for the evaluation of the credit quality of borrowers. The starting point for this new approach from the regulator can be found in the ECB guidelines on Non-Performing Loans, later endorsed by the Bank of Italy Guidelines for Less Significant Banks, aimed at encouraging banks to define their NPL management processes and establish reduction plans to achieve NPL ratio targets in line with the regulator's expectations. Consistently with the focus on NPL, the regulation on Calendar Provisioning, amending the CRR was issued; as being a Regulation, it involves all banks, and not only significant ones (for which the ECB Addendum also applies). In addition, the new definition of default (the so-called "new Dod") has defined stricter criteria for the transition of exposures to the default status and also made the return of "cured" exposures to the performing status more difficult. The combined effect of these regulatory changes has been to make the default of counterparties not only more probable but also much more "expensive" for the banks. The natural “next step” of these regulatory changes was to "move backward" into the management process covering loan origination and monitoring . The EBA's stated objective with the issuance of the GL LOM is to define "robust and prudent" standards of lending practices so as to maintain a low level of NPLs in the future. Therefore, the focus of the GL LOM is the definition of requirements (some outlined as prescriptions, others in terms of principles) for the creditworthiness assessment of counterparties and for the management of the related data and information. Notwithstanding the fact that the Final Report has articulated the principle of proportionality much more clearly as compared to the Consultation Paper, the GLs set out three macro-categories of counterparties for which specific requirements are defined: • Individuals • Micro and small businesses • Medium and large companies. The GL LOM also provide recommendations about the valuation of guarantees both at origination and during ongoing monitoring, encouraging the use of advanced statistical models. The GL LOM focus on real estate guarantees, while financial collateral is outside the scope of the GL LOM. In the mind of the regulator, the GL LOM should not only reflect industry practices, but also incorporate the latest supervisory guidance on lending, and provide the stimulus to include ESG, AML/CTF and the use of innovative technologies into banking origination and, where applicable, monitoring processes.

Este estudo objetiva avaliar o desenvolvimento motor, estado nutricional, nível de mercúrio e perfil socioeconômico de crianças residentes na Ilha de Cotijuba, Pará, Brasil, na faixa etária de 5 a 10 anos. Metodologicamente, o desenvolvimento motor foi avaliado através do protocolo TGMD – 2 (Test of Gross Motor Development, Secunde Edition). A avaliação do estado nutricional da amostra, utilizou o software WHO AntroPlus. A análise de mercúrio foi realizada através da metodologia de redução e espectrometria de absorção atômica por vapor frio (CVAAS) (sistema aberto de circulação do fluxo de ar), utilizando um detector de mercúrio automático, o Automatic Mercury analyzer Model HG-201 da Sanso Seisakusho Co. Ltd., Tokyo, Japan. Para a avaliação socioeconômica da amostra, foi utilizado o instrumento CCEB 2014 (Critério de Classificação Econômica Brasil 2014) da ABEP. A análise dos dados foi realizada pelo programa SPSS 22.0, em que se adotou a estatística descritiva de tendência central, não central e dispersão e para a estatística inferencial primeiramente foi realizado o teste de Kolmogorov-Smirnov para normalidade da amostra, e o Teste t independente para comparar as médias da amostra de acordo com o sexo e grupo etário. O teste de correlação de Pearson foi utilizado para analisar o grau de associação entre as variáveis. Foi adotado um nível de significância p≤0,05. O desenvolvimento motor encontrou-se na média em sua maioria, seguido por abaixo da média e, posteriormente, acima da média. Quanto ao estado nutricional, a maioria apresentou peso adequado para a idade, estatura adequada para idade e eutrofia com o aparecimento de alguns casos de sobrepeso e obesidade com o avançar da idade. O nível de exposição ao mercúrio encontrou-se abaixo do limite de tolerância biológico, com diferença significativa entre sexo. O perfil socioeconômico das famílias, na sua maioria, perteceu às classes C2 e D. A renda média bruta das famílias, majoritariamente, apresentou-se entre R$ 1277,00 e R$ 895,00. Conclui-se que a avaliação do desenvolvimento motor e os fatores intervenientes a este estão na normalidade. Análises similares devem ocorrer periodicamente para planejamento legislativo e projetos de intervenção em educação e saúde.