Relevant bibliographies by topics / C57BL/6 female mice

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'C57BL/6 female mice'

Author: Grafiati
Published: 4 June 2021
Last updated: 19 February 2022

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the lists of relevant articles, books, theses, conference reports, and other scholarly sources on the topic 'C57BL/6 female mice.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Journal articles on the topic "C57BL/6 female mice"

1

Fahlström, Andreas, Qian Yu, and Brun Ulfhake. "Behavioral changes in aging female C57BL/6 mice." Neurobiology of Aging 32, no. 10 (2011): 1868–80. http://dx.doi.org/10.1016/j.neurobiolaging.2009.11.003.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Sanders, J. Michael, Gabriel A. Knudsen та Linda S. Birnbaum. "The Fate of β-Hexabromocyclododecane in Female C57BL/6 Mice". Toxicological Sciences 134, № 2 (2013): 251–57. http://dx.doi.org/10.1093/toxsci/kft121.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Zhang, Steven B., Shanmin Yang, Zhenhuan Zhang, et al. "Thoracic gamma irradiation-induced obesity in C57BL/6 female mice." International Journal of Radiation Biology 93, no. 12 (2017): 1334–42. http://dx.doi.org/10.1080/09553002.2017.1385871.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Wadsworth, P. F. "Tumours of the bone in C57BL/10J mice." Laboratory Animals 23, no. 4 (1989): 324–27. http://dx.doi.org/10.1258/002367789780745971.

Full text
Abstract:
Tumours of the bone were found in 17 (12 females and 5 males) of 6768 (0·25%) C57BL/10J mice (3384 males and 3384 females) pooled from 14 oncogenic studies carried out from 1973 to 1987. Tumours of bone were found predominantly in female mice and were age related. The tumours were classified histologically as osteosarcoma (5 osteoblastic, 6 mixed type and 1 fibroblastic), chondroma (2), chondromyxoid fibroma (1), chondrosarcoma (1) and periosteal fibroma (1).
APA, Harvard, Vancouver, ISO, and other styles
5

Zhu, Jie, Wei Cui, and Yan-Feng Dai. "Production of inbred offspring by intracytoplasmic sperm injection of oocytes from juvenile female mice." Reproduction, Fertility and Development 30, no. 3 (2018): 451. http://dx.doi.org/10.1071/rd16399.

Full text
Abstract:
The aim of the present study was to determine whether the use of oocytes from juvenile female mice would improve the efficiency of intracytoplasmic sperm injection (ICSI). In the present study, 15 adult and 14 juvenile C57BL6/J female mice were superovulated, with 17.8 oocytes per mouse harvested from adults, significantly lower than the 40.2 harvested from juveniles (P < 0.01). Sixty and 233 oocytes were harvested from C57BL/6J adult and juvenile mice respectively, activated in 10 mM SrCl2 + 5 μg mL−1 cytochalasin B for 5–6 h and cultured in potassium simplex optimisation medium (KSOM) for 3.5 days, with no differences in morula and blastocyst rates between groups (91.7% vs 96.6%; P > 0.05). Twelve hours after injection of human chorionic gonadotrophin, oocytes were harvested from C57BL/6J juvenile mice into KSOM, randomly divided into groups and activated with the same method mentioned above at 0, 2, 4 or 6 h and then cultured in KSOM for 3.5 days. There was no significant difference in morula and blastocyst rates among the different groups (P > 0.05). Oocytes from juvenile mice activated in 10 mM SrCl2 for 2 h were subjected to ICSI and the rates of pronuclear formation and Day 1 cleavage were significantly improved compared with the control group (P < 0.01). ICSI combined with activation of oocytes from inbred mouse strains (C57BL/6J, C57BL/6N and 129Svev) successfully produced pups. The fertility of some these mice resulting from ICSI was tested, and the animals proved fertile. In conclusion, superovulated juvenile mice can yield more useable oocytes than adult mice, but additional activation is essential for full development of ICSI oocytes harvested from juvenile inbred mice.
APA, Harvard, Vancouver, ISO, and other styles
6

Tongkao-on, Wannit, Chen Yang, Bianca Y. McCarthy та ін. "Sex Differences in Photoprotective Responses to 1,25-Dihydroxyvitamin D3 in Mice Are Modulated by the Estrogen Receptor-β". International Journal of Molecular Sciences 22, № 4 (2021): 1962. http://dx.doi.org/10.3390/ijms22041962.

Full text
Abstract:
Susceptibility to photoimmune suppression and photocarcinogenesis is greater in male than in female humans and mice and is exacerbated in female estrogen receptor-beta knockout (ER-β−/−) mice. We previously reported that the active vitamin D hormone, 1,25-dihydroxyvitamin D3 (1,25(OH)2D), applied topically protects against the ultraviolet radiation (UV) induction of cutaneous cyclobutane pyrimidine dimers (CPDs) and the suppression of contact hypersensitivity (CHS) in female mice. Here, we compare these responses in female versus male Skh:hr1 mice, in ER-β−/−/−− versus wild-type C57BL/6 mice, and in female ER-blockaded Skh:hr1 mice. The induction of CPDs was significantly greater in male than female Skh:hr1 mice and was more effectively reduced by 1,25(OH)2D in female Skh:hr1 and C57BL/6 mice than in male Skh:hr1 or ER-β−/− mice, respectively. This correlated with the reduced sunburn inflammation due to 1,25(OH)2D in female but not male Skh:hr1 mice. Furthermore, although 1,25(OH)2D alone dose-dependently suppressed basal CHS responses in male Skh:hr1 and ER-β−/− mice, UV-induced immunosuppression was universally observed. In female Skh:hr1 and C57BL/6 mice, the immunosuppression was decreased by 1,25(OH)2D dose-dependently, but not in male Skh:hr1, ER-β−/−, or ER-blockaded mice. These results reveal a sex bias in genetic, inflammatory, and immune photoprotection by 1,25(OH)2D favoring female mice that is dependent on the presence of ER-β.
APA, Harvard, Vancouver, ISO, and other styles
7

Garner, Angela M., John N. Norton, Will L. Kinard, Grace E. Kissling, and Randall P. Reynolds. "Vibration-induced Behavioral Responses and Response Threshold in Female C57BL/6 Mice." Journal of the American Association for Laboratory Animal Science 57, no. 5 (2018): 447–55. http://dx.doi.org/10.30802/aalas-jaalas-17-00092.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

Kania-Korwel, Izabela, Mohammed H. M. E. El-Komy, Peter Veng-Pedersen, and Hans-Joachim Lehmler. "Clearance of Polychlorinated Biphenyl Atropisomers is Enantioselective in Female C57Bl/6 Mice†." Environmental Science & Technology 44, no. 8 (2010): 2828–35. http://dx.doi.org/10.1021/es901781p.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Alsina-Llanes, Marcela, Victoria De Brun, and Daniel E. Olazábal. "Development and expression of maternal behavior in naïve female C57BL/6 mice." Developmental Psychobiology 57, no. 2 (2015): 189–200. http://dx.doi.org/10.1002/dev.21276.

Full text
APA, Harvard, Vancouver, ISO, and other styles
10

Bahougne, Thibault, Eleni Angelopoulou, Nathalie Jeandidier, and Valérie Simonneaux. "Individual evaluation of luteinizing hormone in aged C57BL/6 J female mice." GeroScience 42, no. 1 (2019): 323–31. http://dx.doi.org/10.1007/s11357-019-00104-z.

Full text
APA, Harvard, Vancouver, ISO, and other styles
More sources

Dissertations / Theses on the topic "C57BL/6 female mice"

1

Makley, Meghan Katherine. "NMR analyses show TCDD elicits differences in hepatic metabolism in female C57BL/6 mice and Sprague-Dawley rats." Wright State University / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=wright1230048333.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Santos, Fernanda Araujo dos. "Xenotransplante ovariano de gatas domésticas em camundongas C57BL/6 SCID e sua resposta á gonadotrofina coriõnica equina." Universidade Federal Rural do Semi-Árido, 2015. http://bdtd.ufersa.edu.br:80/tede/handle/tede/382.

Full text
Abstract:
Made available in DSpace on 2016-08-15T20:31:29Z (GMT). No. of bitstreams: 1 FernandaAS_DISSERT.pdf: 1414995 bytes, checksum: e7e006bb87888d5b4777f2f259d7afd8 (MD5) Previous issue date: 2015-09-29<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>Ovarian xenografting is an auxiliary reproductive technique that allows the conservation of germplasm of high value livestock or endangered species. The use of exogenous gonadotropins assists in developing these xenografted tissues and obtaining viable follicles for in vitro embryo production (IVEP), however this use has not been reported in xenograftings of cats ovaries with C57BL/6 SCID female mice as recipients. Thus, the aim of this study was to evaluate the response of xenografting of domestic cat ovaries to equine chorionic gonadotropin (eCG) when grafted into C57BL/6 SCID female mice. Therefore, domestic cats ovarian cortex fragments were grafted under the kidney capsule of fifteen C57BL/6 SCID mice after bilateral ovariectomy. At the end of 45 days, the female mice were divided into two groups and those who did not receive hormone induction (eCG ) were euthanized at the time of induction. Females who received hormonal induction (eCG +) were euthanized after 48 hours. All collected tissues were taken for histologic processing. The proportions between the different ovarian follicles were compared by the chi-square test. The morphometric analysis of the follicles were compared between the experimental groups by the Tukey test (primordial follicles, primary and secondary) and Kruskal-Wallis (antral follicles). Macroscopically, it was possible to observe a low number (16%) of antral follicles with more than 1mm in transplants treated with eCG. In the microscopic analysis, follicles from all categories were observed in transplants and all had normal morphology and morphometry for the studied species (Felis catus), being however observed larger primordial and primary follicles in those eCG + transplants. There was a decrease in primordial follicles percentages and an increase in subsequent categories, mainly in antral follicles of eCG + group, and this condition is proposed here characterized as Follicular Right Shift (FRS). Luteinized follicles were also observed in transplants treated with eCG. Thus, it is concluded that the treatment with eCG is effective when it comes to follicular development, but it did not show a good superovulatory response<br>Xenotransplante ovariano é uma técnica reprodutiva auxiliar que permite a conservação do germoplasma de espécies de alto valor zootécnico ou em perigo de extinção. O uso de gonadotrofinas exógenas auxilia no desenvolvimento desses tecidos xenotransplantados e na obtenção de folículos viáveis para produção in vitro de embriões (PIVE), entretanto esse uso não foi relatado em xenotransplante de ovários de gatas com fêmeas C57BL/6 SCID como receptora. Dessa forma, o objetivo desse trabalho foi avaliar a resposta do xenotransplante ovariano de gata doméstica à gonadotrofina coriônica equina (eCG) quando transplantados em fêmeas C57BL/6 SCID. Para tanto, fragmentos de córtex ovariano de gatas domésticas foram transplantados sob a cápsula renal de quinze camundongas C57BL/6 SCID após ovariectomia bilateral. Ao final de 45 dias, as fêmeas foram divididas em dois grupos e aquelas que não receberam indução hormonal (eCG ) foram eutanasiadas no momento da indução. As fêmeas que receberam indução hormonal (eCG +) foram eutanasiadas 48h após. Todos os tecidos colhidos foram levados para processamento histológico. As proporções entre os diferentes folículos ovarianos foram comparadas pelo teste de qui-quadrado. A análise morfométrica dos folículos foi comparada entre os grupos experimentais pelo teste de Tukey (folículos primordial, primário e secundário) e Kruskal-Wallis (folículo antral). Macroscopicamente foi possível observar um baixo número (16%) de folículos antrais com mais de 1mm nos transplantes tratados com eCG. Na análise microscópica, folículos de todas as categorias foram observados nos transplantes e todos apresentaram morfologia e morfometria normais para a espécie estudada (Felis catus), sendo, porém observado folículos primordiais e primários maiores naqueles transplantes eCG +. Houve uma redução nas porcentagens de folículos primordiais e aumento nas categorias subsequentes, principalmente nas de folículos antrais do grupo eCG +, sendo essa condição caracterizada como Follicular Right Shift (FRS). Folículos luteinizados também foram observados nos transplantes tratados com eCG. Dessa maneira, conclui-se que o tratamento com eCG foi eficaz em se tratando de desenvolvimento folicular, mas não apresentou boa resposta superovulatória
APA, Harvard, Vancouver, ISO, and other styles
3

Neelakantan, Harshini. "REWARD-RELATED BEHAVIORAL EFFECTS OF PRESCRIPTION OPIOIDS AS A FUNCTION OF PUTATIVE ACUTE AND CHRONIC PAIN-LIKE STATES IN MALE AND FEMALE C57BL/6 MICE." Diss., Temple University Libraries, 2014. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/270439.

Full text
Abstract:
Pharmaceutical Sciences<br>Ph.D.<br>Pain is a leading cause of disability and the most common reason for clinical care. The field of pain research has focused on sex differences in the recent years with an expansive body of literature demonstrating sex-related differences in pain behavior and responsiveness to pharmacological interventions. Prescription opioids are potent analgesics and the mainstay for the clinical management of moderate-to-severe acute and chronic pain conditions. However, the long-term clinical use of prescription opioids for chronic pain remains controversial due to concerns about severe adverse effects, including tolerance, dependence, and addiction associated with opioid use. The non-medical use and abuse of prescription opioids has become a public health crisis, the problem even arising in a subset of chronic pain patients receiving opioid therapy. The vulnerability factors, specifically the role of pain in the propensity to prescription opioid abuse, are poorly understood. The present research project sought to investigate the propensity to opioid reward as a function of pain in male and female mice by incorporating acute (acetic acid-induced) visceral nociceptive and chronic chemotherapy (paclitaxel)-induced peripheral neuropathic pain models. Sexually dimorphic variations in the sensitivities of mice to nociceptive and allodynic behaviors were initially assessed using the two putative pain models. Following that, the two prescription opioids, morphine and oxycodone were examined under both pain contexts and the capacity of the two prescription opioids to produce reward-related behavioral effects were measured using drug discrimination, conditioned place preference, and intravenous drug self-administration procedures. The presence of acute noxious state but not chronic pain selectively attenuated the discriminative stimulus effects of the prescription opioid, morphine in male mice. The magnitude of modulation of the stimulus effects of opioids by the acute noxious state were further observed to be inversely related to the relative intrinsic antinociceptive effectiveness of the two opioids in reversing the acute noxious state and sex-specific sensitivities of mice to opioid-induced antinociception. In contrast, while no change was observed in opioid-reward as a function of the acute noxious state in both sexes, the presence of paclitaxel-induced chronic pain opioid-selectively and dose-selectively enhanced the conditioned rewarding effect of morphine (0.3 mg/kg dose), and the effect was more pronounced in male relative to female mice. These data were further supported by the self-administration results, in that the reinforcing efficacy (breakpoints under progressive ratio (PR) responding) and the incentive-motivational salience of morphine significantly increased in the presence of chronic pain in male mice, while non-selectively increasing regardless of the presence/absence of pain in female mice. Overall, the converging empirical evidence presented here suggest that these models provide preclinical tools to further understand the overlapping neurobiology of pain and opioid abuse, the behavioral effects of prescription opioids, and advance the development of novel sex-specific pain therapeutics with low addiction liability.<br>Temple University--Theses
APA, Harvard, Vancouver, ISO, and other styles
4

Edgar, Nicole M. "Mechanisms of Compass Orientation in C57BL/6 Laboratory Mice." Thesis, Virginia Tech, 2004. http://hdl.handle.net/10919/32850.

Full text
Abstract:
Compass orientation or menotaxis is defined as the ability to orient at a specific angle relative to a directional cue. Cues used for compass orientation include the sun, stars, moon, geomagnetic field and polarized light. While there is evidence in a variety of organisms for compass orientation, the ability of mammals to use cues for compass orientation has been relatively unexplored. The goal of this research was to explore whether laboratory mice could use either magnetic or auditory cues for compass orientation. The results indicate that mice are able to learn to position their nest using a magnetic compass. The development of a magnetic compass assay in laboratory mice will allow the investigation of the mechanism of magnetic compass orientation in mammals, a goal that has been unattainable to this point.In addition, this research has provided preliminary evidence that mice are able to learn to position their nests using an auditory compass. While there is evidence in several organisms for place navigation using auditory cues (i.e. the ability to locate a specific spatial position using auditory cues), this is the first evidence in any organism for an auditory compass (i.e. the ability to calculate a directional heading relative to an auditory cue).In conclusion, both experiments provide evidence for specialized compass systems in mice and suggest that further research is necessary to fully understand the role of these systems in the behavioral ecology of mice.<br>Master of Science
APA, Harvard, Vancouver, ISO, and other styles
5

OBAFEMI, TOLULOPE FESAYO. "THE EFFECTS OF INTERLEUKIN 6 AND INTERLEUKIN 10 ON FRAILTY IN C57BL/6 MICE." Thesis, The University of Arizona, 2016. http://hdl.handle.net/10150/613394.

Full text
Abstract:
Studies have shown that pro-inflammatory IL-6 and anti-inflammatory IL-10 interleukins may correlate to frailty and aging. This frailty can be defined in the context of clinical symptoms which include sarcopenia and osteoporosis, decreased activity level; or in the context of increased susceptibility to adverse health outcomes from a deficient immune system. In this experiment we tested a cohort of conditionally regulated IL-6 and IL-10 mice with controls (IL-6tg+.rtTA(r/r) (n=8), IL-10(-/-). IL-10tg+ rtTA(r/r) (n=10) and rtTA(r/r) (n=5)) under frailty assessments and immunological cell analysis. We were unable to successfully induce expression in the conditionally regulated mice. Subsequently, there was no difference in the frailty scores, weight, or temperature fluctuation between all three genotypes. As a preliminary study, there arose essential learning points of improvement that can be applied to future experiments concerning frailty in transgenic mice.
APA, Harvard, Vancouver, ISO, and other styles
6

Araghi-Niknam, Moshen 1960. "Effects of dehydroepiandrosterone supplementation in aged humans and C57BL/6 mice." Diss., The University of Arizona, 1997. http://hdl.handle.net/10150/282417.

Full text
Abstract:
DHEA (dehydroepiandrosterone) is a major adrenal hormone, with known accepted function. In both animals and humans low DHEA and DHEA-sulfate levels are associated with a number of problems in the aging: immunosenescence, increased mortality, increased incidence of several cancers, loss of sleep, decreased feelings of well-being, osteoporosis, atherosclerosis and premature death. DHEA hormone replacement in aged mice significantly normalized immunosenescence suggesting that this hormone plays a key role in aging and stimulating immune regulation in mice. Similarly osteoclasts and lymphoid cells, were stimulated by DHEA replacement which should delay osteoporosis. Recent studies do not support the original suggestion that low serum DHEA levels were associated with Alzheimer's and other losses of mental function in aged people. As DHEA modulates energy metabolism low levels should affect lipogenesis and gluconeogenesis, increasing the risk of diabetes and heart disease. Most of the actions of DHEA restoration are hypothesized from epidemiological or animal model studies and need to be tested in human trials. Those conducted in humans show essentially no toxicity of DHEA treatment at levels restoring serum DHEAS levels without evidence of altering some aging physiological systems. Thus DHEA is a steroid whose deficiency could facilitate development of some diseases common to the aged. Dehydroepiandrosterone (DHEA) and DHEA-sulfate (DHEAS) are steroids, synthesized from cholesterol (Fig. 1.1). While DHEA is secreted primarily by the adrenal gland in larger quantities than any other adrenal steroid including cortisol, the precise functions of DHEA and DHEAS in humans are not known (1-5). The decline of DHEAS levels during aging is parallel to development of immunosensecence, an inability to conserve protein, a physical frailty, decreased muscle mass, an increased fat mass, decreased ability to cope, disrupted sleep patterns and increased incidence of disease. Thus DHEAS serves as a marker of aging in humans. While the precise biological functions of DHEA and DHEAS are not known, both animal and human studies suggest some hypotheses while dispelling others. Therefore key physiological dysfunctions are investigated here to determine biological relationships which participate in the declining blood levels of DHEA with age.
APA, Harvard, Vancouver, ISO, and other styles
7

Romao, P. L. "Mapping ENU-induced thymic lymphoma susceptibility loci in C57BL/6 mice." Thesis, University of Nottingham, 2017. http://eprints.nottingham.ac.uk/47379/.

Full text
Abstract:
Tumour development is a complex process involving susceptibility loci (oncogenes) and the accumulation of spontaneous somatic mutations in tumour suppressor genes that interact to result in cancer. Tumours may require the accumulation of a variety of mutations before developing but the general principle is that the mutations result in an imbalance between the oncogene and tumour suppressor gene function (Berger et al., 2011). This multi-hit process can be tested by subjecting strains of mice susceptible to certain types of tumours to chemical mutagens, thereby inducing further mutations. This technique is used in this study to identify loci resulting in the susceptibility to thymic lymphoma in the C57BL/6J strain in order to further our understanding of the processes involved in the development of such tumours.
APA, Harvard, Vancouver, ISO, and other styles
8

Johnson, Joshua Edward Newland M. Christopher. "The opportunity for alternative reinforcement shortens bout length in BALB/c C57BL/6 mice." Auburn, Ala, 2008. http://repo.lib.auburn.edu/EtdRoot/2008/SUMMER/Psychology/Thesis/Johnson_Joshua_56.pdf.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Percelay, Solenn. "Validation d'un modèle murin de schizophrénie pour améliorer la recherche de nouveaux traitements : approche psychopharmacologique, en imagerie et en électrophysiologie A new 3-hit mouse model of schizophrenia built on genetic, early and late factors Functional dysregulations in CA1 hippocampal networks of a 3-hit mouse model of schizophrenia Olfactory laterality is valence-dependent in mice Assessing olfactory laterality in mice: new tool in preclinical psychiatric study Combination of MAP6 deficit, maternal separation and MK801 in female mice: a 3-hit animal model of neurodevelopmental disorder with cognitive deficits Antipsychotic lurasidone: Behavioural and pharmacokinetic data in C57BL/6 mice." Thesis, Normandie, 2021. http://www.theses.fr/2021NORMC403.

Full text
Abstract:
La schizophrénie est une maladie psychiatrique très invalidante qui concerne près de 1% de la population. Bien que son étiologie soit toujours inconnue, elle est certainement multifactorielle et comprend une interaction entre prédisposition génétique et facteurs environnementaux. Il existe des traitements médicamenteux mais ils ne sont pas totalement efficaces, particulièrement pour la prise en charge des symptômes négatifs et des déficits cognitifs. Le développement de nouveaux traitements plus efficaces passe par l’amélioration des modèles animaux prenant en compte le caractère multifactoriel de l’étiologie de cette pathologie.Nous avons développé un modèle murin multifactoriel de schizophrénie innovant (modèle 3-hit) présentant une forte validité de construction. Pour cela, nous avons combiné une modification génétique (1er hit : délétion partielle du gène MAP6) avec un stress environnemental précoce (2nd hit : séparation maternelle de 24h au 9ème jour de vie) et une exposition tardive au THC durant l’adolescence (3ème hit : administration quotidienne de tétrahydrocannabinol à 8mg/kg du 32ème au 52ème jour).Dans un premier temps, nous avons montré une bonne validité d’apparence de ce modèle à travers des études comportementale, en imagerie et en électrophysiologie. En effet, au niveau comportemental les souris 3-hit présentent des symptômes de type négatif, des déficits cognitifs et une altération de la latéralité olfactive. Nous avons aussi montré un déficit d’inhibition du réflexe de sursaut, qui est un élément comportemental clef dans les modèles animaux de schizophrénie, car il est également utilisé en recherche clinique. Nous avons également observé certaines altérations morphologiques et fonctionnelles cérébrales caractéristiques de la schizophrénie comme une réduction du volume de l’hippocampe, une altération des fibres du corps calleux et un dysfonctionnement des systèmes de neurotransmission glutamatergique et GABAergique. Certains dimorphismes sexuels ont été également montrés dans nos études.Dans un deuxième temps, nous avons comparé les déficits des animaux 3-hit avec ceux d’autres modèles de schizophrénie développés au laboratoire. La caractérisation des effets de chaque facteur, indépendamment et en association, nous a permis de mettre en évidence un phénomène de synergie entre les facteurs et non une simple addition des déficits induits par chacun d’entre eux.Le modèle de schizophrénie 3-hit présente de bonnes validités de construction et d’apparence, il est maintenant nécessaire afin de parfaire sa caractérisation de tester sa validité pharmacologique<br>Affecting 1% of worldwide population, schizophrenia is a debilitating pathology. Whether the aetiology of schizophrenia remains unknown, its multifactorial aspect is conversely now well admitted, and certainly gathers genetic vulnerability and environmental factors. Actual treatments are still unmet, particularly for negative and cognitive symptoms. For a better translation from treatments design of schizophrenia to clinical efficiency, there is a crucial need to refine preclinical animal models that considers the multifactorial aspects of this disease.We developed a new murine multifactorial model of schizophrenia (3-hit), that possesses a strong construct validity. To this, we combined a genetic predisposition (1st hit: partial deletion of MAP-6) with an early postnatal stress (2nd hit: 24 h maternal separation at postnatal day 9), and a late cannabinoid exposure during adolescence (3rd hit: tetrahydrocannabinol THC from post-natal day 32 to 52; 8 mg/kg/day).First, we characterised a promising face validity through behavioural, imaging and electrophysiological studies. At behavioural level, we demonstrated that 3-hit mice displayed negative-like symptoms, cognitive deficits and altered olfactory laterality. Moreover, we showed a sensory motor gating deficit, that is a major translational clue for animal models of schizophrenia. Additionally, 3-hit mice displayed some characteristic morphological and functional impairments of the disease: reduced hippocampal volume, altered callosal fibres, glutamatergic and GABAergic neurotransmission dysfunctions. We moreover highlighted some sexual dimorphisms.Second, we compared deficits of 3-hit mice to those of others models of schizophrenia developed in our laboratory. Deficits induced by one factor, or combination of several factors, evidenced a synergistic effect, and not a simple addition between each of them.The 3-hit model therefore presents strong construct validity and promising face validity, encouraging to assess the pharmacological validity
APA, Harvard, Vancouver, ISO, and other styles
10

Philibin, Scott D. "The Discriminative Stimulus Properties of the Atypical Antipsychotic Clozapine in C57BL/6 Mice." VCU Scholars Compass, 2006. http://scholarscompass.vcu.edu/etd/1318.

Full text
Abstract:
Serotonin and α1 adrenergic receptor antagonism may contribute to atypical antipsychotic drug effects. Clozapine (2.5 mg/kg) drug discrimination in C57BL/6 mice may selectively screen atypical antipsychotic drugs. Previous data show that the atypical antipsychotics olanzapine, risperidone, ziprasidone but not the typical antipsychotic haloperidol fully substitutes for clozapine. The present study demonstrated that the atypical antipsychotics quetiapine, sertindole, zotepine, iloperidone, melperone fully substituted for clozapine but aripiprazole did not. The typical antipsychotics fluphenazine and perphenazine failed to fully substitute for clozapine but chlorpromazine and thioridazine fully substituted for clozapine. This model does not differentiate between atypical and typical antipsychotic drugs but it may be useful in the detection of antipsychotics with potent serotonin and α1 adrenergic receptor antagonist actions.
APA, Harvard, Vancouver, ISO, and other styles
More sources

Books on the topic "C57BL/6 female mice"

1

Penner, Mark Douglas. NK cell mediated cellular cytotoxicity in C57BL/6 mice transgenic for antisene natural killer cell tumour recognition molecule p150. National Library of Canada, 1993.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
2

(Editor), P. R. Hof, W. G. Young (Editor), F. E. Bloom (Editor), P. V. Belichenko (Editor), and M. R. Celio (Editor), eds. Comparative Cytoarchitectonic Atlas of the C57BL/6 and 129/Sv Mouse Brains. Elsevier, 2000.

Find full text
APA, Harvard, Vancouver, ISO, and other styles

Book chapters on the topic "C57BL/6 female mice"

1

Sprecher, Eli, Leonard D. Shultz, and Yechiel Becker. "Epidermal Dendritic Cells in Aged C57BL/6 J MICE." In Skin Langerhans (Dendritic) Cells in Virus Infections and AIDS. Springer US, 1991. http://dx.doi.org/10.1007/978-1-4615-3942-1_6.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Contarini, Gabriella, Pietro Giusti, and Stephen D. Skaper. "Active Induction of Experimental Autoimmune Encephalomyelitis in C57BL/6 Mice." In Neurotrophic Factors. Springer New York, 2017. http://dx.doi.org/10.1007/978-1-4939-7571-6_26.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Drickamer, Lee C. "Chemosignals and Reproduction in Adult Female House Mice." In Chemical Signals in Vertebrates 6. Springer US, 1992. http://dx.doi.org/10.1007/978-1-4757-9655-1_38.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Gonsalvez, David G., SangWon Yoo, Georgina A. Craig, et al. "Myelin Protein Zero180–199 Peptide Induced Experimental Autoimmune Neuritis in C57BL/6 Mice." In Methods in Molecular Biology. Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-7862-5_19.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Perlman, S., R. Schelper, and D. Ries. "Maternal Antibody-Modulated MHV-JHM Infection in C57BL/6 and BALB/c Mice." In Coronaviruses. Springer US, 1987. http://dx.doi.org/10.1007/978-1-4684-1280-2_39.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Spongr, Vlasta P., Joseph P. Walton, Robert D. Frisina, Ann Marie Kazee, Dorothy G. Flood, and Richard J. Salvi. "Hair Cell Loss and Synaptic Loss in Inferior Colliculus of C57BL/6 MICE." In Acoustical Signal Processing in the Central Auditory System. Springer US, 1997. http://dx.doi.org/10.1007/978-1-4419-8712-9_49.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Marchlewska-Koj, A., M. Kruczek, and M. Zacharczuk-Kakietek. "Olfactory Signals of Conspecifics Stimulate Adrenal Function in Female Mice." In Chemical Signals in Vertebrates 6. Springer US, 1992. http://dx.doi.org/10.1007/978-1-4757-9655-1_43.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

Gagne, S., L. Thibodeau, and L. Lamontagne. "Clonal Deletion of Some Vβ+ T Cells in Peripheral Lymphocytes from C57BL/6 Mice Infected with MHV3." In Advances in Experimental Medicine and Biology. Springer US, 1998. http://dx.doi.org/10.1007/978-1-4615-5331-1_62.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Sandnabba, N. Kenneth. "Odor Discrimination in Female Mice after Long-Term Exposure to Male Odors: Genotype-Environment Interaction." In Chemical Signals in Vertebrates 6. Springer US, 1992. http://dx.doi.org/10.1007/978-1-4757-9655-1_78.

Full text
APA, Harvard, Vancouver, ISO, and other styles
10

Pyo, Hyun Mi, Jie Yun Park, Sue Nie Park, Hyun Su Kim, Kee Sun Shin, and Har Young Poo. "Immunization with Virus-Like Particle of Human Papillomavirus Type 16 L1 Elicits CTL Immune Response in C57BL/6 Mice." In Key Engineering Materials. Trans Tech Publications Ltd., 2005. http://dx.doi.org/10.4028/0-87849-958-x.119.

Full text
APA, Harvard, Vancouver, ISO, and other styles

Conference papers on the topic "C57BL/6 female mice"

1

Brass, David M., Mary K. Dunkel, Sarah M. Reilly, Jacob M. Tobolewski, and Cheryl L. Fattman. "Female C57BL/6 And Ec-sod Null Mice Are Partially Protected From Silica-Induced Lung Fibrosis." In American Thoracic Society 2010 International Conference, May 14-19, 2010 • New Orleans. American Thoracic Society, 2010. http://dx.doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a1989.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Kishta, O., N. Dauletbaev, and LC Lands. "Time Course of Lung Infection with Pseudomonas aeruginosa in Female C57BL/6 Mice: Contribution of Oxidative Stress." In American Thoracic Society 2009 International Conference, May 15-20, 2009 • San Diego, California. American Thoracic Society, 2009. http://dx.doi.org/10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a5751.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Neumann, U., F. Derwenskus, A. Gille, S. Louis, and SC Bischoff. "BIOAVAILABILITY AND SAFETY OF THREE MICROALGAE IN C57BL/6 MICE." In Nutrition 2017 – Ernährung: eine multiprofessionelle Herausforderung. Georg Thieme Verlag KG, 2017. http://dx.doi.org/10.1055/s-0037-1603260.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Nishio, Naomi, Sachiko Ito, Yuriko Tanaka, and Ken-ichi Isobe. "Establishment of neutrophil-lineage stem cells from C57BL/6 mice." In 2012 International Symposium on Micro-NanoMechatronics and Human Science (MHS). IEEE, 2012. http://dx.doi.org/10.1109/mhs.2012.6492412.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Zin, Walter, Gaudio Sena, Giovanna Carvalho, et al. "Pulmonary burden in C57Bl/6 mice infected withplasmodiumbergheistrains NK65 or ANKA." In Annual Congress 2015. European Respiratory Society, 2015. http://dx.doi.org/10.1183/13993003.congress-2015.pa2311.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Turner, Charles H., and Alexander G. Robling. "Genetic Effects on Skeletal Mechanosensitivity in Mice." In ASME 2002 International Mechanical Engineering Congress and Exposition. ASMEDC, 2002. http://dx.doi.org/10.1115/imece2002-32596.

Full text
Abstract:
The accumulation of bone mass during growth can be enhanced by environmental factors such as mechanical loading (exercise) or calcium intake, but 60–70% of the variance in adult bone mineral density (BMD) is explained by heredity. Consequently, understanding the signaling pathways targeted by the genes governing bone accumulation holds perhaps the greatest potential in reducing fracture incidence later in life. Rodent models are particularly useful for studying the genetics of skeletal traits. Of the available inbred mouse strains, three in particular have been studied extensively in skeletal genetics: C57BL/6, DBA/2, and C3H/He. The C57BL/6 strain is characterized by low BMD and large total cross-sectional area (CSA) in the midshaft femur; the C3H/He strain exhibits very high femoral BMD and a smaller femoral CSA than the C57BL/6 mice; and DBA/2 mice have moderately high femoral BMD and a very small midshaft femur CSA. Mechanical loading of the skeleton during growth can substantially enhance periosteal bone apposition, and ultimately produce a diaphyseal cross section with enlarged area. Therefore we hypothesized that the mouse strain with greater femoral cross-sectional area (C57BL/6) might have a genetic predisposition for greater mechanosensitivity than mice with smaller cross sections (C3H/He and DBA/2).
APA, Harvard, Vancouver, ISO, and other styles
7

Jiang, Dingyuan, Xiaoxi Huang, Jing Geng, Shuhong Li, Chen Wang, and Huaping Dai. "Repeated boost withpropionibacterium acnesinduce pulmonary fibrosis following sarcoidosis in C57BL/6 mice." In Annual Congress 2015. European Respiratory Society, 2015. http://dx.doi.org/10.1183/13993003.congress-2015.pa3313.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

Carvalho, Jorge Luis, Ana Karolina Sá, Aurileia Britto, et al. "Bifidobacterium breve significantly reduces cigarette smoke-induced COPD in C57Bl/6 mice." In ERS International Congress 2018 abstracts. European Respiratory Society, 2018. http://dx.doi.org/10.1183/13993003.congress-2018.pa4244.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Nikolskaya, Kira, and Marina Kondashevskaya. "AGING PROBLEM: PSYCHOPHYSIOLOGICAL AND NEUROIMMUNO-HORMONAL EFFECTS IN MICE F1 (C57BL/6×DBA/2)." In XVI International interdisciplinary congress "Neuroscience for Medicine and Psychology". LLC MAKS Press, 2020. http://dx.doi.org/10.29003/m1179.sudak.ns2020-16/348-349.

Full text
APA, Harvard, Vancouver, ISO, and other styles
10

Silva, C. R., C. F. M. Camargo, D. P. Aureliano, L. R. De Pretto, A. Z. Freitas, and M. S. Ribeiro. "Attenuation coefficient of the light in skin of BALB/c and C57BL/6 mice." In SPIE Biophotonics South America, edited by Cristina Kurachi, Katarina Svanberg, Bruce J. Tromberg, and Vanderlei S. Bagnato. SPIE, 2015. http://dx.doi.org/10.1117/12.2181015.

Full text
APA, Harvard, Vancouver, ISO, and other styles
You might also be interested in the extended bibliographies on the topic 'C57BL/6 female mice' for particular source types:
Journal articles Dissertations / Theses
We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!

To the bibliography