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Journal articles on the topic 'C57BL/6 mice'

Author: Grafiati

Published: 4 June 2021

Last updated: 7 September 2023

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1

Lim, Jana P., Mimi E. Zou, Patricia H. Janak, and Robert O. Messing. "Responses to ethanol in C57BL/6 versus C57BL/6 × 129 hybrid mice." Brain and Behavior 2, no. 1 (2012): 22–31. http://dx.doi.org/10.1002/brb3.29.

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Middaugh, Lawrence D., Brian M. Kelley, Angela-Leigh E. Bandy, and Kimberly K. McGroarty. "Ethanol Consumption by C57BL/6 Mice." Alcohol 17, no. 3 (1999): 175–83. http://dx.doi.org/10.1016/s0741-8329(98)00055-x.

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Pfau, Jean C., Jami J. Sentissi, Sheng'ai Li, Lilian Calderon-Garcidueñas, Jared M. Brown, and David J. Blake. "Asbestos-Induced Autoimmunity in C57Bl/6 Mice." Journal of Immunotoxicology 5, no. 2 (2008): 129–37. http://dx.doi.org/10.1080/15476910802085756.

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4

Middaugh, Lawrence D., and Brian M. Kelley. "Operant Ethanol Reward in C57BL/6 Mice." Alcohol 17, no. 3 (1999): 185–94. http://dx.doi.org/10.1016/s0741-8329(98)00056-1.

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5

Szade, Agata, Witold N. Nowak, Krzysztof Szade, et al. "Effect of Crossing C57BL/6 and FVB Mouse Strains on Basal Cytokine Expression." Mediators of Inflammation 2015 (2015): 1–10. http://dx.doi.org/10.1155/2015/762419.

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C57BL/6 is the most often used laboratory mouse strain. However, sometimes it is beneficial to cross the transgenic mice on the C57BL/6 background to the other strain, such as FVB. Although this is a common strategy, the influence of crossing these different strains on homeostatic expression of cytokines is not known. Here we have investigated the differences in the expression of selected cytokines between C57BL/6J and C57BL/6JxFVB mice in serum and skeletal muscle. We have found that only few cytokines were altered by crossing of the strains. Concentrations of IL5, IL7, LIF, MIP-2, and IP-10

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Archer Slone, Emily, Byron Sparkes, Mary Roth, Ruth Welti, and Sherry Fleming. "Intestinal ischemia/reperfusion-induced lipid alterations do not correlated with damage or PGE2 production (90.12)." Journal of Immunology 184, no. 1_Supplement (2010): 90.12. http://dx.doi.org/10.4049/jimmunol.184.supp.90.12.

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Abstract Ischemia/reperfusion (IR)-induced injury results in severe tissue damage and causes up to 30,000 human deaths per year in the US. In a mouse model of intestinal IR, C57Bl/6 mice experience significant intestinal damage; however Rag-1-/- mice, which are antibody deficient, do not sustain significant damage. Complement activation is also critical as indicated by the lack of damage in complement receptor 2 deficient (CR2-/-) mice. Additionally, when Rag-1-/- or CR2-/- mice are pretreated with C57Bl/6 antibodies or specific anti-phospholipid monoclonal antibodies, damage is restored to C5

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7

Deacon, R. M. J., C. L. Thomas, J. N. P. Rawlins, and B. J. Morley. "A comparison of the behavior of C57BL/6 and C57BL/10 mice." Behavioural Brain Research 179, no. 2 (2007): 239–47. http://dx.doi.org/10.1016/j.bbr.2007.02.009.

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Taherzadeh, Zhila, Ed VanBavel, Judith de Vos, et al. "Strain-dependent susceptibility for hypertension in mice resides in the natural killer gene complex." American Journal of Physiology-Heart and Circulatory Physiology 298, no. 4 (2010): H1273—H1282. http://dx.doi.org/10.1152/ajpheart.00508.2009.

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Hypertension is associated with chronic vascular inflammation. We tested the hypothesis that the sensitivity to develop hypertension and vascular remodeling depends on the immunological background. Blood pressure, vascular remodeling, endothelial function, vascular architecture (number of collateral arteries), and expression of inflammatory cytokines were determined in mice that received NG-nitro-l-arginine methyl ester (l-NAME) to inhibit nitric oxide synthesis. We studied C57BL/6, BALB/c, and BALB.B6-Cmv1r mice, a congenic strain where the natural killer (NK) gene complex of C57BL/6 mice is

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9

Mekada, Kazuyuki, and Atsushi Yoshiki. "Substrains matter in phenotyping of C57BL/6 mice." Experimental Animals 70, no. 2 (2021): 145–60. http://dx.doi.org/10.1538/expanim.20-0158.

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Jalel, Akrem, Mrabet Yassine, and MohamedHedi Hamdaoui. "Oxidative stress in experimental vitiligo C57Bl/6 mice." Indian Journal of Dermatology 54, no. 3 (2009): 221. http://dx.doi.org/10.4103/0019-5154.55628.

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Galus, Ryszard, Krzysztof Włodarski, Jacek Malejczyk, and Jarosław Jóźwiak. "Fluvastatin Influences Hair Color in C57Bl/6 Mice." International Journal of Molecular Sciences 14, no. 7 (2013): 14333–45. http://dx.doi.org/10.3390/ijms140714333.

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12

Gould, Thomas J. "Ethanol disrupts fear conditioning in C57BL/6 mice." Journal of Psychopharmacology 17, no. 1 (2003): 77–81. http://dx.doi.org/10.1177/0269881103017001702.

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13

Fahlström, Andreas, Qian Yu, and Brun Ulfhake. "Behavioral changes in aging female C57BL/6 mice." Neurobiology of Aging 32, no. 10 (2011): 1868–80. http://dx.doi.org/10.1016/j.neurobiolaging.2009.11.003.

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14

Cheng, Zhao, Sachiko Ito, Naomi Nishio, Suganya Thanasegaran, He Fang, and Ken-ichi Isobe. "Characteristics of cardiac aging in C57BL/6 mice." Experimental Gerontology 48, no. 3 (2013): 341–48. http://dx.doi.org/10.1016/j.exger.2013.01.005.

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15

Zabihi, Ebrahim, Abbas Soleymani, and Leila Ghassemi. "Diazinon-induced ulcerative keratitis in C57bl/6 mice." Journal of Ocular Biology, Diseases, and Informatics 5, no. 1 (2012): 25–30. http://dx.doi.org/10.1007/s12177-012-9095-9.

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Morgan, Daniel L., Gordon P. Flake, Patrick J. Kirby, and Scott M. Palmer. "Respiratory Toxicity of Diacetyl in C57Bl/6 Mice." Toxicological Sciences 103, no. 1 (2008): 169–80. http://dx.doi.org/10.1093/toxsci/kfn016.

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Lang, Roland, Helmut Hintner, Anton Hermann, and Roland Brandstaetter. "Photoperiod modulates melanoma growth in C57BL/6 mice." Experimental Dermatology 12, no. 4 (2003): 510–13. http://dx.doi.org/10.1034/j.1600-0625.2003.00004.x.

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Middauch, Lawrence D., William O. Boggan, and Carrie L. Randall. "Stimulatory effects of ethanol in C57BL/6 mice." Pharmacology Biochemistry and Behavior 27, no. 3 (1987): 421–24. http://dx.doi.org/10.1016/0091-3057(87)90343-1.

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19

Nguyen, Shaun A., Robert Malcolm, and Lawrence D. Middaugh. "Topiramate reduces ethanol consumption by C57BL/6 mice." Synapse 61, no. 3 (2007): 150–56. http://dx.doi.org/10.1002/syn.20350.

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Ponomarenko, Е. А., V. A. Mkhitarov, S. A. Kuzikyants, et al. "CYTOLOGICAL CHARACTERISTIC OF SPERMATOGENIC EPITHELIUM CELLS IN C57Bl/6 MICE." CLINICAL AND EXPERIMENTAL MORPHOLOGY 27, no. 3 (2018): 42–52. http://dx.doi.org/10.31088/2226-5988-2018-27-3-42-52.

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Heller, Tanja, J. Engelbert Gessner, Reinhold E. Schmidt, Andreas Klos, Wilfried Bautsch, and Jörg Köhl. "Cutting Edge: Fc Receptor Type I for IgG on Macrophages and Complement Mediate the Inflammatory Response in Immune Complex Peritonitis." Journal of Immunology 162, no. 10 (1999): 5657–61. http://dx.doi.org/10.4049/jimmunol.162.10.5657.

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Abstract The contributions of Fc receptors (FcRs) for IgG (FcγRs) and complement to immune complex (IC)-mediated peritonitis were evaluated in BALB/c-, C57BL/6-, FcRγ chain-, and FcR type III for IgG (FcγRIII)-deficient mice, backcrossed to the C57BL/6 background. In BALB/c mice, but not in C57BL/6 mice, neutrophil migration was markedly attenuated after complement depletion. In mice lacking FcRγ chain, neutrophil migration was abolished, whereas it was unaffected in FcγRIII-deficient mice. Huge amounts of TNF-α (TNF) were found in the peritoneal exudate of BALB/c and C57BL/6 mice but were abs

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Breitbach, Katrin, Sonja Klocke, Thomas Tschernig, Nico van Rooijen, Ulrich Baumann, and Ivo Steinmetz. "Role of Inducible Nitric Oxide Synthase and NADPH Oxidase in Early Control of Burkholderia pseudomallei Infection in Mice." Infection and Immunity 74, no. 11 (2006): 6300–6309. http://dx.doi.org/10.1128/iai.00966-06.

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ABSTRACT Infection with the soil bacterium Burkholderia pseudomallei can result in a variety of clinical outcomes, including asymptomatic infection. The initial immune defense mechanisms which might contribute to the various outcomes after environmental contact with B. pseudomallei are largely unknown. We have previously shown that relatively resistant C57BL/6 mice can restrict bacterial B. pseudomallei growth more efficiently within 1 day after infection than highly susceptible BALB/c mice. By using this model, our study aimed to investigate the role of macrophage-mediated effector mechanisms

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TOENJES, S. A., R. J. SPOLSKI, K. A. MOONEY та R. E. KUHN. "γδT cells do not play a major role in controlling infection in experimental cysticercosis". Parasitology 119, № 4 (1999): 413–18. http://dx.doi.org/10.1017/s0031182099004771.

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Protective immunity against larval Taenia crassiceps has been shown to rely on T cells; however, the roles of the specific subsets of T cells during infection are not known. To investigate a possible role for γδT cells, this study investigated larval infection in δ-chain knock-out C57BL/6 (deltaKO) and wild-type C57BL/6 mice. It was found that deltaKO mice and C57BL/6 mice were equally susceptible to infection suggesting γδT cells do not play a major role in protective immunity. Cytokine production by concanavalin A (ConA)-stimulated spleen cells from infected deltaKO mice and C57BL/6 mice wer

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Damlund, Dina Silke Malling, Stine Broeng Metzdorff, Jane Preuss Hasselby, et al. "Postnatal Hematopoiesis and Gut Microbiota in NOD Mice Deviate from C57BL/6 Mice." Journal of Diabetes Research 2016 (2016): 1–15. http://dx.doi.org/10.1155/2016/6321980.

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Neonatal studies in different mouse strains reveal that early life colonization affects the development of adaptive immunity in mice. The nonobese diabetic (NOD) mouse spontaneously develops autoimmune diabetes, but neonatal studies of NOD mice are lacking. We hypothesized that NOD mice deviate from another much used mouse strain, C57BL/6, with respect to postnatal microbiota and/or hematopoiesis and compared this in newborn mice of dams housed under the same conditions. A distinct bacteria profile rich instaphylococciwas found at postnatal days (PND) 1–4 in NOD mice. Furthermore, a distinct s

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Liu, Tie, Tetsuya Matsuguchi, Naotake Tsuboi, Toshiki Yajima, and Yasunobu Yoshikai. "Differences in Expression of Toll-Like Receptors and Their Reactivities in Dendritic Cells in BALB/c and C57BL/6 Mice." Infection and Immunity 70, no. 12 (2002): 6638–45. http://dx.doi.org/10.1128/iai.70.12.6638-6645.2002.

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ABSTRACT We have previously reported that differences in early production of interleukin 12 (IL-12) by dendritic cells (DC) underlies the difference between the susceptibilities to Listeria monocytogenes of C57BL/6 and BALB/c mice. To elucidate mechanisms for the different abilities of DC to produce cytokine in C57BL/6 and BALB/c mice, we examined Toll-like receptor (TLR) expression by DC and their responses in vitro to known microbial ligands for TLRs. We found that DC isolated from the spleens of naive C57BL/6 mice preferentially expressed TLR9 mRNA, whereas DC from naive BALB/c mice strongl

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Zeytun, Ahmet, Mitzi Nagarkatti, and Prakash S. Nagarkatti. "Growth of FasL-bearing tumor cells in syngeneic murine host induces apoptosis and toxicity in Fas+ organs." Blood 95, no. 6 (2000): 2111–17. http://dx.doi.org/10.1182/blood.v95.6.2111.

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Abstract In the current study, we investigated whether the growth of FasL-bearing tumor cells would induce apoptosis and toxicity in organs that express high level of Fas. Sera from C57BL/6 +/+(wild-type) mice injected with syngeneic FasL+ tumors, LSA, or EL-4, showed significantly higher levels of soluble FasL than that from the nontumor-bearing mice. Furthermore, the soluble FasL was functional inasmuch as the sera from tumor-bearing mice were able to induce apoptosis in Fas+ but not Fas−targets. Histopathologic studies and in situ TUNEL assay to detect apoptosis were carried out in C57BL/6

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27

Bohn, Erwin, Edgar Schmitt, Claudia Bielfeldt, Annette Noll, Ralf Schulte, and Ingo B. Autenrieth. "Ambiguous Role of Interleukin-12 in Yersinia enterocolitica Infection in Susceptible and Resistant Mouse Strains." Infection and Immunity 66, no. 5 (1998): 2213–20. http://dx.doi.org/10.1128/iai.66.5.2213-2220.1998.

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ABSTRACT Endogenous interleukin-12 (IL-12) mediates protection againstYersinia enterocolitica in C57BL/6 mice by triggering gamma interferon (IFN-γ) production in NK and CD4+ T cells. Administration of exogenous IL-12 confers protection against yersiniae in Yersinia-susceptible BALB/c mice but exacerbates yersiniosis in resistant C57BL/6 mice. Therefore, we wanted to dissect the different mechanisms exerted by IL-12 during Yersiniainfections by using different models of Yersinia-resistant and -susceptible mice, including resistant C57BL/6 mice, susceptible BALB/c mice, intermediate-susceptible

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28

Lipoff, Danielle M., Ankur Bhambri, Georgia J. Fokas, et al. "Neocortical molecular layer heterotopia in substrains of C57BL/6 and C57BL/10 mice." Brain Research 1391 (May 2011): 36–43. http://dx.doi.org/10.1016/j.brainres.2011.03.026.

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29

Rendina-Ruedy, Elizabeth, Kelsey D. Hembree, Angela Sasaki, et al. "A Comparative Study of the Metabolic and Skeletal Response of C57BL/6J and C57BL/6N Mice in a Diet-Induced Model of Type 2 Diabetes." Journal of Nutrition and Metabolism 2015 (2015): 1–13. http://dx.doi.org/10.1155/2015/758080.

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Type 2 diabetes mellitus (T2DM) represents a complex clinical scenario of altered energy metabolism and increased fracture incidence. The C57BL/6 mouse model of diet-induced obesity has been used to study the mechanisms by which altered glucose homeostasis affects bone mass and quality, but genetic variations in substrains of C57BL/6 may have confounded data interpretation. This study investigated the long-term metabolic and skeletal consequences of two commonly used C57BL/6 substrains to a high fat (HF) diet. Male C57BL/6J, C57BL/6N, and the negative control strain, C3H/HeJ, mice were fed a c

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Garcia-Menendez, Lorena, Georgios Karamanlidis, Stephen Kolwicz, and Rong Tian. "Substrain specific response to cardiac pressure overload in C57BL/6 mice." American Journal of Physiology-Heart and Circulatory Physiology 305, no. 3 (2013): H397—H402. http://dx.doi.org/10.1152/ajpheart.00088.2013.

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The C57BL/6 mouse strain is one of the most commonly used in experimental research. It is known to differ from other strains in baseline cardiovascular phenotypes as well as in response to pressure overload induced by aortic constriction. Since the generation of the C57BL/6 mouse line over a century ago, multiple substrains have been generated from the original. To identify potential substrain specific differences in response to pressure overload, we evaluated the effects of transverse aortic constriction (TAC) on survival, cardiac function, and expression of hypertrophic markers in three comm

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Lau, John C., and M. George Cherian. "Developmental changes in hepatic metallothionein, zinc, and copper levels in genetically altered mice." Biochemistry and Cell Biology 76, no. 4 (1998): 615–23. http://dx.doi.org/10.1139/o98-030.

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Using mice that either overexpress metallothionein 1 (MT-1*) or do not express metallothionein 1 and 2 (MT-null) and a control strain (C57BL/6), the essential metal storage function of hepatic metallothionein and its subcellular localization were investigated during development. Hepatic metallothionein, zinc, and copper levels were measured in all groups from gestational day 20 to 60 days of age. Hepatic metallothionein levels were maximal during the perinatal period in both MT-1* and C57BL/6 mice with levels approximately three times higher in MT-1* mice. MT-null mice had no detectable hepati

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Durmus, Nedim, Wen-Chi Chen, Sung-Hyun Park та ін. "Resistin-like Molecule α and Pulmonary Vascular Remodeling: A Multi-Strain Murine Model of Antigen and Urban Ambient Particulate Matter Co-Exposure". International Journal of Molecular Sciences 24, № 15 (2023): 11918. http://dx.doi.org/10.3390/ijms241511918.

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Pulmonary hypertension (PH) has a high mortality and few treatment options. Adaptive immune mediators of PH in mice challenged with antigen/particulate matter (antigen/PM) has been the focus of our prior work. We identified key roles of type-2- and type-17 responses in C57BL/6 mice. Here, we focused on type-2-response-related cytokines, specifically resistin-like molecule (RELM)α, a critical mediator of hypoxia-induced PH. Because of strain differences in the immune responses to type 2 stimuli, we compared C57BL/6J and BALB/c mice. A model of intraperitoneal antigen sensitization with subseque

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Rau, Cheng-Shyuan, Shao-Chun Wu, Tsu-Hsiang Lu, et al. "Effect of Low-Fat Diet in Obese Mice Lacking Toll-like Receptors." Nutrients 10, no. 10 (2018): 1464. http://dx.doi.org/10.3390/nu10101464.

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Background: This study aimed at assessing the effect of a low-fat diet (LFD) in obese mice lacking toll–like receptors (Tlr) and understanding the expression and regulation of microRNAs during weight reduction. Methods: C57BL/6, Tlr5−/−, Tlr2−/− and Tlr4−/− mice were used in this study. A group of mice were fed with a high-fat diet (HFD) (58% kcal) for 12 weeks to induce obesity (diet-induced obesity, DIO). Another group that had been fed with HFD for eight weeks (obese mice) were switched to a low-fat diet (LFD) (10.5% kcal) for the next four weeks to reduce their body weight. The control mic

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Wakeham, Julia, Jun Wang, and Zhou Xing. "Genetically Determined Disparate Innate and Adaptive Cell-Mediated Immune Responses to Pulmonary Mycobacterium bovis BCG Infection in C57BL/6 and BALB/c Mice." Infection and Immunity 68, no. 12 (2000): 6946–53. http://dx.doi.org/10.1128/iai.68.12.6946-6953.2000.

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ABSTRACT The current study was designed to investigate the impact of genetic heterogeneity on host immune responses to pulmonary intracellular infection by using two mouse strains of distinct genetic background, C57BL/6 and BALB/c mice, and a model intracellular pathogen,Mycobacterium bovis BCG. Upon infection, compared to C57BL/6 mice, BALB/c mice developed an earlier response of interleukin 12 (IL-12), gamma interferon (IFN-γ), tumor necrosis factor alpha, and macrophage chemoattractive protein 1, and greater neutrophilic influx to the lung by days 7 and 14. However, the level of these cytok

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Bäcklund, Johan, Cuiqin Li, Erik Jansson, et al. "C57BL/6 mice need MHC class II Aq to develop collagen-induced arthritis dependent on autoreactive T cells." Annals of the Rheumatic Diseases 72, no. 7 (2012): 1225–32. http://dx.doi.org/10.1136/annrheumdis-2012-202055.

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IntroductionCollagen-induced arthritis (CIA) has traditionally been performed in MHC class II Aq-expressing mice, whereas most genetically modified mice are on the C57BL/6 background (expressing the b haplotype of the major histocompatibility complex (MHC) class II region). However, C57BL/6 mice develop arthritis after immunisation with chicken-derived collagen type II (CII), but arthritis susceptibility has been variable, and the immune specificity has not been clarified.ObjectiveTo establish a CIA model on the C57BL/6 background with a more predictable and defined immune response to CII.Resu

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Czuprynski, Charles J., Nancy G. Faith, and Howard Steinberg. "A/J Mice Are Susceptible and C57BL/6 Mice Are Resistant to Listeria monocytogenes Infection by Intragastric Inoculation." Infection and Immunity 71, no. 2 (2003): 682–89. http://dx.doi.org/10.1128/iai.71.2.682-689.2003.

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ABSTRACT Previous studies demonstrated that the innate resistance of mice to Listeria monocytogenes infection by intravenous or intraperitoneal inoculation is regulated principally by the Hc locus on mouse chromosome 2. The A/J and C57BL/6 mouse strains were identified as prototype L. monocytogenes-susceptible and -resistant strains, respectively. In the present study, we compared the relative susceptibilities of A/J and C57BL/6 mice to intragastric (i.g.) inoculation with L. monocytogenes. The results of our study indicate that A/J mice are significantly more susceptible than C57BL/6 mice to

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Teixeira, H. C., and S. H. Kaufmann. "Role of NK1.1+ cells in experimental listeriosis. NK1+ cells are early IFN-gamma producers but impair resistance to Listeria monocytogenes infection." Journal of Immunology 152, no. 4 (1994): 1873–82. http://dx.doi.org/10.4049/jimmunol.152.4.1873.

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Abstract An enzyme-linked immunospot assay was used for detection of splenic IFN-gamma and IL-4 spot-forming cells from, C57Bl/6 and BALB/c mice, which differ in resistance to systemic L. monocytogenes infection. Numbers of spontaneous and Ag (heat-killed listeriae)-induced IFN-gamma SFC were 5- to 10-fold higher in C57Bl/6 as compared to BALB/c mice at day 1, day 7, and day 14 postinfection. In both strains of mice, Ag-induced IFN-gamma production reached maximum levels at day 7 postinfection and IL-4 production was slightly increased at day 1, decreasing thereafter. The early IFN-gamma produ

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Wu, Shao-Chun, Cheng-Shyuan Rau, Tsu-Hsiang Lu, et al. "Effect of Weight-Reduction in Obese Mice Lacking Toll-Like Receptor 5 and C57BL/6 Mice Fed a Low-Fat Diet." Mediators of Inflammation 2015 (2015): 1–12. http://dx.doi.org/10.1155/2015/852126.

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Background. This study aims to investigate the effect of feeding low-fat diet (LFD) to diet-induced obesity (DIO) mice lacking TLR5 (TLR5−/−), which have a tendency to develop glucose intolerance with increased adiposity, compared to that in C57BL/6 mice.Results. TLR5−/−and C57BL/6 male mice were divided into three subgroups: (1) control, mice were fed a standard AIN-76A (fat: 11.5 kcal%) diet for 12 weeks; (2) DIO, mice were fed a 58 kcal% high-fat diet (HFD) for 12 weeks; and (3) diet, mice were fed a HFD for 8 weeks to induce obesity and then switched to a 10.5 kcal% LFD for 4 weeks. The gl

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Cohen, Glenn M., and Joseph S. Grasso. "Neural Degeneration in the Spiral Ganglia of C57BL/6 Mice." Proceedings, annual meeting, Electron Microscopy Society of America 46 (1988): 136–37. http://dx.doi.org/10.1017/s0424820100102766.

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C57BL/6 mice, along with several other mouse genotypes, have served as models for human presbycusis (age-related hearing losses). C57BL/6 mice and their genetic substrain C57/bl6 show progressively severe hearing losses, starting as early as 30 days postnatally. The hearing losses result from sweeping sensory (hair cell) and neural degeneration that begins in the basal end and advances apically. For the initial study of the spiral ganglia C57BL/6 mice, our two objectives were to develop criteria for identifying the different degenerative stages and determine Whether the same degenerative stage

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Zhao, Liang, Megan K. Mulligan, and Thaddeus S. Nowak. "Substrain- and sex-dependent differences in stroke vulnerability in C57BL/6 mice." Journal of Cerebral Blood Flow & Metabolism 39, no. 3 (2017): 426–38. http://dx.doi.org/10.1177/0271678x17746174.

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The C57BL/6 mouse strain is represented by distinct substrains, increasingly recognized to differ genetically and phenotypically. The current study compared stroke vulnerability among C57BL/6 J (J), C57BL/6JEiJ (JEiJ), C57BL/6ByJ (ByJ), C57BL/6NCrl (NCrl), C57BL/6NJ (NJ) and C57BL/6NTac (NTac) substrains, using a model of permanent distal middle cerebral artery and common carotid artery occlusion. Mean infarct volume was nearly two-fold smaller in J, JEiJ and ByJ substrains relative to NCrl, NJ and NTac (N-lineage) mice. This identifies a previously unrecognized confound in stroke studies invo

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Quintero, Eric A., Katherine A. Gott, and Julie A. Wilder. "Evidence of Murine Alternatively Activated Lung Macrophages are Associated with Failure to Clear Pulmonary Cryptococcus neoformans (133.54)." Journal of Immunology 182, no. 1_Supplement (2009): 133.54. http://dx.doi.org/10.4049/jimmunol.182.supp.133.54.

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Abstract We have previously shown that murine pulmonary immunity to the fungal pathogen Cryptococcus neoformans (Cne) is genetically regulated. C.B-17 mice efficiently clear the organism from the lung following intranasal inoculation whereas C57BL/6 mice do not. The ability to clear Cne from the lungs of C.B-17 mice is dependent upon the development of a Type 1 immune response. In contrast, infected C57BL/6 mice mount a Type 2 immune response. As alternatively activated macrophages (AAMs) have been associated with the development of a Type 2 immune response, we reasoned that Cne-infected C57BL

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Qi, Miao, Rong Liu, Bing Li, et al. "Behavioral Effect of Terahertz Waves in C57BL/6 Mice." Biosensors 12, no. 2 (2022): 79. http://dx.doi.org/10.3390/bios12020079.

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Terahertz is a new radiation source with many unique advantages. In recent years, its application has rapidly expanded to various fields, but there are few studies on the individual effects of terahertz. In this study, we investigated the behavioral effects of terahertz radiation on C57BL/6 mice, and we conducted an open field test, an elevated plus maze test, a light–dark box test, a three-chamber social test, and a forced swim test to explore the effects of terahertz radiation on mice from a behavioral perspective. The results show that terahertz wave may increase anti-anxiety, anti-depressi

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Kang, Hye-Min, Inkyung Sohn, Seunggyu Kim, et al. "Optical Measurement of Mouse Strain Differences in Cerebral Blood Flow Using Indocyanine Green." Journal of Cerebral Blood Flow & Metabolism 35, no. 6 (2015): 912–16. http://dx.doi.org/10.1038/jcbfm.2015.50.

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C57BL/6 mice have more cerebral arterial branches and collaterals than BALB/c mice. We measured and compared blood flow dynamics of the middle cerebral artery (MCA) in these two strains, using noninvasive optical imaging with indocyanine green (ICG). Relative maximum fluorescence intensity ( Imax) and the time needed for ICG to reach Imax in the MCA of C57BL/c were lower than that in BALB/c mice. Moreover, the mean transit time was significantly lower in C57BL/6 than in BALB/c mice. These data suggest that the higher number of arterial branches and collaterals in C57BL/6 mice yields a lower bl

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Desroches-Castan, Agnès, Emmanuelle Tillet, Nicolas Ricard, et al. "Differential Consequences of Bmp9 Deletion on Sinusoidal Endothelial Cell Differentiation and Liver Fibrosis in 129/Ola and C57BL/6 Mice." Cells 8, no. 9 (2019): 1079. http://dx.doi.org/10.3390/cells8091079.

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The aim of the present work was to address the role of BMP9 in different genetic backgrounds (C57BL/6, BALB/c, and 129/Ola) of mice deleted for Bmp9. We found that Bmp9 deletion led to premature mortality only in the 129/Ola strain. We have previously shown that Bmp9 deletion led to liver sinusoidal endothelial cells (LSEC) capillarization and liver fibrosis in the 129/Ola background. Here, we showed that this is not the case in the C57BL/6 background. Analysis of LSEC from Wild-type (WT) versus Bmp9-KO mice in the C57BL/6 background showed no difference in LSEC fenestration and in the express

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Hapak, Sophie, and Vaiva Vezys. "C57BL/6 mice cohoused with pet shop mice phenocopy immune-related adverse events associated with checkpoint inhibition." Journal of Immunology 210, no. 1_Supplement (2023): 85.10. http://dx.doi.org/10.4049/jimmunol.210.supp.85.10.

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Abstract Checkpoint inhibition has been successful in the treatment of a number of malignancies. These medications block inhibitory pathways in T cells and allow for their improved function in anti-tumor immune responses. An important factor limiting checkpoint inhibitor therapy is immune-related adverse events (irAE), which can involve any organ system. It is currently not possible to predict which patients will develop irAE or which tissues will be affected. Our understanding of the cellular and molecular factors driving irAE development remains limited, as immune sufficient specific pathoge

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Yonekura, Ichiro, Nobutaka Kawahara, Hirofumi Nakatomi, Kazuhide Furuya, and Takaaki Kirino. "A Model of Global Cerebral Ischemia in C57 BL/6 Mice." Journal of Cerebral Blood Flow & Metabolism 24, no. 2 (2004): 151–58. http://dx.doi.org/10.1097/01.wcb.0000096063.84070.c1.

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A reproducible model of global cerebral ischemia in mice is essential for elucidating the molecular mechanism of ischemic neuronal injury. Such a model is particularly important in the mouse because many genetically engineered mutant animals are available. In C57BL/6 and SV129/EMS mice, we evaluated a three-vessel occlusion model. Occlusion of the basilar artery with a miniature clip was followed by bilateral carotid occlusion. The mean cortical cerebral blood flow was reduced to less than 10% of the preischemic value, and the mean anoxic depolarization was attained within 1 minute. In C57BL/6

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Chen, Chun-Rong, H. Aliesky, P. N. Pichurin, Y. Nagayama, S. M. McLachlan, and B. Rapoport. "Susceptibility Rather than Resistance to Hyperthyroidism Is Dominant in a Thyrotropin Receptor Adenovirus-Induced Animal Model of Graves’ Disease as Revealed by BALB/c-C57BL/6 Hybrid Mice." Endocrinology 145, no. 11 (2004): 4927–33. http://dx.doi.org/10.1210/en.2004-0716.

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Abstract We investigated why TSH receptor (TSHR) adenovirus immunization induces hyperthyroidism more commonly in BALB/c than in C57BL/6 mice. Recent modifications of the adenovirus model suggested that using adenovirus expressing the TSHR A subunit (A-subunit-Ad), rather than the full-length TSHR, and injecting fewer viral particles would increase the frequency of hyperthyroidism in C57BL/6 mice. This hypothesis was not fulfilled; 65% of BALB/c but only 5% of C57BL/6 mice developed hyperthyroidism. TSH binding inhibitory antibody titers were similar in each strain. Functional TSHR antibody me

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Powell, Daniel, Man Ma, Nate Weyand, Magdalene So, and Jeffrey Frelinger. "Oral colonization with Neisseria highlights differences in wild derived mouse immune responses (MPF6P.650)." Journal of Immunology 194, no. 1_Supplement (2015): 202.8. http://dx.doi.org/10.4049/jimmunol.194.supp.202.8.

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Abstract Neisseria species have the ability to colonize the host as either a commensal or pathogen depending on the strain and anatomical location. Human Neisseria species carriage estimates can reach as high as 50% of the population. Investigations of the immunological changes induced by Neisseria carriage, to date, have been inhibited by the lack of a small animal model. Here we set out to develop a mouse model of commensal Neisseria colonization. Three wild derived inbred mouse strains (PWK, WSB and CAST) along with C57BL/6 were tested. These mice were inoculated orally with a Neisseria str

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Martins de Sousa, Eduardo, Fernando Bonfim de Bortoli, Eduardo Pinheiro Amaral, et al. "Acute Immune Response to Mycobacterium massiliense in C57BL/6 and BALB/c Mice." Infection and Immunity 78, no. 4 (2010): 1571–81. http://dx.doi.org/10.1128/iai.00731-09.

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ABSTRACT Mycobacterium massiliense is an environmental opportunistic pathogen that has been associated with soft tissue infection after minor surgery. We studied the acute immune response of C57BL/6 and BALB/c mice infected intravenously with 106 CFU of an M. massiliense strain isolated from a nosocomial infection in Brazil. The results presented here show that M. massiliense is virulent and pathogenic to both C57BL/6 and BALB/c mice, inducing a granulomatous inflammatory reaction that involves the activation of macrophages, dendritic cells, and natural killer cells induced by gamma interferon

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Sunderkötter, C., M. Kunz, K. Steinbrink, et al. "Resistance of mice to experimental leishmaniasis is associated with more rapid appearance of mature macrophages in vitro and in vivo." Journal of Immunology 151, no. 9 (1993): 4891–901. http://dx.doi.org/10.4049/jimmunol.151.9.4891.

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Abstract Resistance to murine leishmaniasis has been related to the propagation of specific Th cell subsets (Th1 and Th2). This study shows that there are differences between resistant and susceptible mice in the initial myelomonocytic infiltrate, which precede the specific T cell response. After subcutaneous injection of 2 x 10(7) Leishmania major into footpads of resistant C57Bl/6 and susceptible BALB/c mice we performed immunohistochemical studies on the infiltrate. Two days after infection the percentage of more mature, F4/80-positive macrophages in the lesion increased faster in C57Bl/6 m

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