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Journal articles on the topic 'C8DTCA'

Author: Grafiati

Published: 6 September 2023

Last updated: 31 July 2025

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1

Tahir, Waqas, Basant Abdulrahman, Dalia H. Abdelaziz, Simrika Thapa, Rupali Walia, and Hermann M. Schätzl. "An astrocyte cell line that differentially propagates murine prions." Journal of Biological Chemistry 295, no. 33 (2020): 11572–83. http://dx.doi.org/10.1074/jbc.ra120.012596.

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Prion diseases are fatal infectious neurodegenerative disorders in human and animals caused by misfolding of the cellular prion protein (PrPC) into the pathological isoform PrPSc. Elucidating the molecular and cellular mechanisms underlying prion propagation may help to develop disease interventions. Cell culture systems for prion propagation have greatly advanced molecular insights into prion biology, but translation of in vitro to in vivo findings is often disappointing. A wider range of cell culture systems might help overcome these shortcomings. Here, we describe an immortalized mouse neur

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2

López de Mingo, Isabel, Marco-Xavier Rivera González, Milagros Ramos Gómez, and Ceferino Maestú Unturbe. "The Frequency of a Magnetic Field Determines the Behavior of Tumor and Non-Tumor Nerve Cell Models." International Journal of Molecular Sciences 26, no. 5 (2025): 2032. https://doi.org/10.3390/ijms26052032.

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The involvement of magnetic fields in basic cellular processes has been studied for years. Most studies focus their results on a single frequency and intensity. Intensity has long been the central parameter in hypotheses of interaction between cells and magnetic fields; however, frequency has always played a secondary role. The main objective of this study was to obtain a specific frequency that allows a reduction in the viability and proliferation of glioblastoma (CT2A) and neuroblastoma (N2A) cell models. These were compared with an astrocyte cell model (C8D1A) (nontumor) to determine whethe

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3

Ticona, Luis Apaza, Borja Durán García, Marcos Humanes Bastante, Andreea Madalina Serban, and Ángel Rumbero Sánchez. "Anti-Alzheimer’s and Anti-inflammatory Activities of Compounds Isolated from Solanum Mauritianum." Planta Medica International Open 9, no. 01 (2022): e1-e11. http://dx.doi.org/10.1055/a-1696-6741.

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Abstract Solanum mauritianum, commonly known as “Tabaquillo”, was one of the most used plants by tribes from South America as a remedy for headaches. Based on this ethnopharmacological use, a bioguided isolation of compounds with anti-inflammatory and anti-Alzheimer’s activities from S. mauritianum was carried out by measuring the inhibition of NF-κB in C8D1A, Neuro-2a, and EOC 13.31 cells, and by measuring the inhibition of acetylcholinesterase and β-amyloid. This allowed the isolation and characterisation by nuclear magnetic resonance and mass spectrometry of four compounds (1–4). Compounds

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Mielcarska, Matylda Barbara, Magdalena Bossowska-Nowicka, Karolina Paulina Gregorczyk, Zbigniew Wyzewski, and Felix Ngosa Toka. "Tyrosine kinase Syk interacts with Hrs after TLR3 stimulation in murine microglial cells." Journal of Immunology 198, no. 1_Supplement (2017): 129.17. http://dx.doi.org/10.4049/jimmunol.198.supp.129.17.

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Abstract TLR3 (Toll-like receptor 3) belongs to the family of receptors involved in innate immune response. Present in endosomal compartment in cells, TLR3 recognizes the dsRNA (double-stranded RNA), viral nucleic acid or intermediate during viral replication and initiates signal transduction leading to inflammatory response. However, the first steps of signaling cascade occurring in cells immediately after TLR3 stimulation are still not well understood and require careful attention. In this paper we demonstrate that after poly(I:C) (dsRNA mimetic) stimulation of murine microglial cells (C8D1A

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Mielcarska, Matylda Barbara, Magdalena Bossowska-Nowicka, Karolina Paulina Gregorczyk, Zbigniew Wyzewski, and Felix Ngosa Toka. "TLR3 of murine astrocytes is cleaved into several forms upon stimulation of cells with synthetic dsRNA." Journal of Immunology 200, no. 1_Supplement (2018): 169.4. http://dx.doi.org/10.4049/jimmunol.200.supp.169.4.

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Abstract TLR3 (Toll-like receptor 3) belongs to the subfamily of TLRs that reside in the endosomal compartment of the cell. It recognizes dsRNA (double-stranded RNA) of viruses and initiates a signaling pathway leading to generation of antiviral molecules such as type I interferons. Precursor TLR3 present in mammalian cells has a size of approximately 110 kDa, however, recent findings show that the TLR3 may also occur in two progeny forms: C-terminal and N-terminal, appearing after cleavage of TLR3 in specific conditions by cysteine proteases – cathepsins. Furthermore, cleaved and/or associate

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6

Grlickova-Duzevik, Eliza, Daniel Chiem, James Vaughn, and Ling Cao. "Calcitonin gene related protein antiviral role in LP-BM5 infection of astrocytes and microglia." Journal of Immunology 196, no. 1_Supplement (2016): 217.32. http://dx.doi.org/10.4049/jimmunol.196.supp.217.32.

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Abstract CGRP (calcitonin gene related protein) is a neuropeptide expressed by primary sensory neurons upon infection. LP-BM5 retrovirus infection induces profound immunodeficiency in B6 mice and has been used as a murine model of HIV infection. Previously, we showed that LP-BM5 induced increased CGRP expression in the spinal cords of infected mice. In vitro studies indicated a microglia dependent, CGRP-induced reduction of LP-BM5 viral loads in primary mixed glial cells. To further delineate CGRP’s effects on glial cells, we treated specific murine cell lines (C8D1A astrocyte cell line and C8

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7

Sewell, Leslie, and James J. Cray. "Nicotine alters cellular activity and mRNA expression of patterns of Astrocytes." PLOS One 20, no. 6 (2025): e0325529. https://doi.org/10.1371/journal.pone.0325529.

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Nicotine exposure during neural development presents a significant public health concern. Nicotine, the primary addictive component of tobacco, influences the central nervous system by interacting with various cell types, including the glial cell termed astrocytes. Astrocytes are cells that are critical for supporting neurons, regulating neurotransmitter balance, and managing neuroinflammation. This current study explored nicotine’s effects on astrocytes, examining cellular activity and gene expression within an acute exposure period. Murine C8D1A astrocytic (garnered as a cell line from postn

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8

Zayed, Mohammed, and Byung-Hoon Jeong. "Mesenchymal Stem Cell Secretome Attenuates PrP106-126-Induced Neurotoxicity by Suppressing Neuroinflammation and Apoptosis and Enhances Cell Migration." Cells 14, no. 11 (2025): 851. https://doi.org/10.3390/cells14110851.

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Prion diseases are disorders caused by the misfolding of prion protein (PrPSc), leading to the accumulation of an abnormal form of the normal prion protein (PrP) found in the host. The secretome of mesenchymal stem cells (MSCs), including paracrine-soluble factors, holds promising potential to stimulate host regenerative capability and alleviate organ disorders. In this research, our goal was to investigate the neuroprotective properties of the secretome derived from adipose-derived mesenchymal stem cells (AdMSC secretome) in relation to the toxicity caused by PrP106−126 in SH-SY5Y cells. The

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9

İnco, Adem, Mehmet Salih Aydın, and Yasemin Hacanlı. "Koroner Arter Hastalarında Koroner Anjiyografi Öncesi ve Sonrası Karnitin Profilinin İncelenmesi." Mehes Journal 2, no. 2 (2024): 44–57. https://doi.org/10.5281/zenodo.12574936.

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<strong>Amaç:</strong> Karnitin profilindeki değişiklikler kardiyovasküler hastalıkların patogenezinde rol oynayabilir. Bu çalışma, koroner arter hastaları ile normal bireylerin serbest karnitin profillerini karşılaştırarak kardiyovasküler hastalıkların tanı ve tedavisinde kullanılabilecek yeni belirteçleri belirlemek amacıyla yapılmıştır. <strong>Materyal ve Metot:</strong> Çalışmamızda, koroner arter hastalığı tanısı ile hastanemize gelen 25 hasta (tedavi grup) ve 25 sağlıklı gönüllü birey (kontrol grup) olmak üzere toplam 50 birey &c

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10

Sahu, Umasharan, and Bhagavatula L. V. Prasad. "One‐pot, easy and scalable synthesis of large‐size short wave length IR emitting PbS quantum dots." Photochemistry and Photobiology, July 11, 2024. http://dx.doi.org/10.1111/php.13996.

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AbstractThis study presents a versatile and efficient method to synthesize large‐size lead sulfide (PbS) quantum dots (QDs) that display emission in the short‐wave infrared (SWIR) region, using accessible and stable diethylammonium diethyldithiocarbamate (C2)2DTCA and octylammonium octyldithiocarbamate (C8DTCA) as sulfur sources. As these sulfur sources enable the formation of well‐dispersed, large‐size PbS QDs in a very convenient way, this method can further be taken up for scale‐up studies. Importantly, this approach allows precise control over QD sizes, thereby enhancing their SWIR optical

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11

Mai, Meiting, Xiaorou Guo, Yue Huang, et al. "DHCR24 Knockdown Induces Tau Hyperphosphorylation at Thr181, Ser199, Ser262, and Ser396 Sites via Activation of the Lipid Raft-Dependent Ras/MEK/ERK Signaling Pathway in C8D1A Astrocytes." Molecular Neurobiology, July 8, 2022. http://dx.doi.org/10.1007/s12035-022-02945-w.

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AbstractThe synthetase 3β-hydroxysterol-Δ24 reductase (DHCR24) is a key regulator involved in cholesterol synthesis and homeostasis. A growing body of evidence indicates that DHCR24 is downregulated in the brain of various models of Alzheimer’s disease (AD), such as astrocytes isolated from AD mice. For the past decades, astrocytic tau pathology has been found in AD patients, while the origin of phosphorylated tau in astrocytes remains unknown. A previous study suggests that downregulation of DHCR24 is associated with neuronal tau hyperphosphorylation. Herein, the present study is to explore w

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12

Ouedraogo, Lionel J., Mychal J. Trznadel, McKayla Kling, et al. "Hydrodynamic Assembly of Astrocyte Cells in Conductive Hollow Microfibers." Advanced Biology, November 12, 2023. http://dx.doi.org/10.1002/adbi.202300455.

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AbstractThe manufacturing of 3D cell scaffoldings provides advantages for modeling diseases and injuries as it enables the creation of physiologically relevant platforms. A triple‐flow microfluidic device is developed to rapidly fabricate alginate/graphene hollow microfibers based on the gelation of alginate induced with CaCl2. This five‐channel microdevice actualizes continuous mild fabrication of hollow fibers under an optimized flow rate ratio of 300:200:100 µL min−1. The polymer solution is 2.5% alginate in 0.1% graphene and a 30% polyethylene glycol solution is used as the sheath and core

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13

Uyanikoglu, Hacer, İsmail Koyuncu, Sibel Sak, et al. "Plasma Free Amino Acid and Carnitine Levels in Pregnant Women with Hydatidiform Mole: A Case-Controlled Study." Harran Üniversitesi Tıp Fakültesi Dergisi, April 22, 2024, 131–37. http://dx.doi.org/10.35440/hutfd.1381095.

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Background: To determine plasma free amino acid (FAA) and carnitine levels in pregnant women with hydatidiform mole (HM). Materials and Methods: Twenty-three pregnant women with HM, and 24 healthy pregnant wo-men as controls were enrolled in the study. FAA and carnitine concentrations were measured in plasma using liquid chromatography/tandem mass spectrometry (LC-MS). Results: The levels of alanine, arginine, and valine from the 14 amino acids examined were signif-icantly lower in the HM group than in the healthy group (p = 0.019, p = 0.009, and p = 0.03, respec-tively). In addition, several

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14

Albrecht, Peter. "Konflikte der richterlichen Unabhängigkeit im Massnahmenrecht." Jusletter, no. 1085 (2021). http://dx.doi.org/10.38023/22e3fc5a-c8dc-4c6d-b4d8-1b5c08c478e3.

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15

Binici, Irfan, Halil İbrahim Akbay, Zübeyir Huyut, et al. "Determination of Serum Differential Carnitine Ester Levels in HIV [+] Patients: A Cross-sectional Study." Current HIV Research 21 (December 19, 2022). http://dx.doi.org/10.2174/1570162x21666221219141016.

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Objective: It has been reported that carnitine deficiency is observed in various viral infections and in the follow-up of the prognosis of some diseases. In this cross-sectional study, we aimed to determine how carnitine ester derivatives change in HIV-positive patients. Material and Method: In this study, 25 HIV-infected patients who applied to Harran University Faculty of Medicine Education Research and Practice Hospital Infectious Diseases and Clinical Microbiology Outpatient Clinic and who did not receive any antiretroviral treatment, as well as 25 healthy volunteers were included in the s

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16

Caglayan, Murat. "Investigation of the Effect of Vitamin K Prophylaxis on Newborn Screenings Tests in Newborns." Journal of Medical Biochemistry, December 6, 2022. http://dx.doi.org/10.5937/jomb0-40162.

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Background: Routine screening for hereditary disorders in newborns includes screening for treatable metabolic and endocrine disorders, such as biotidinase deficiency, galactosemia, maple syrup urine disease, hypothyroidism, and cystic fibrosis. Incorrect test results may be encountered due to the use of vitamin K. To investigate the interference effect of vitamin K on neonatal screening tests and to raise awareness of erroneous measurements. Methods: Heel blood samples were taken from 25 newborns born in a neonatal intensive care unit. Dry blood C0, C2, C3, C4, C4DC, C5:1, C5OH, C5DC, C6

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17

Yang, Yanping, Yang Li, Wenyi Yang, et al. "Protecting effects of 4-octyl itaconate on neonatal hypoxic-ischemic encephalopathy via Nrf2 pathway in astrocytes." Journal of Neuroinflammation 21, no. 1 (2024). http://dx.doi.org/10.1186/s12974-024-03121-8.

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Abstract Background Neonatal hypoxic-ischemic encephalopathy (HIE) is one of the most common neurological problems occurring in the perinatal period. However, there still is not a promising approach to reduce long-term neurodevelopmental outcomes of HIE. Recently, itaconate has been found to exhibit anti-oxidative and anti-inflammatory effects. However, the therapeutic efficacy of itaconate in HIE remains inconclusive. Therefore, this study attempts to explore the pathophysiological mechanisms of oxidative stress and inflammatory responses in HIE as well as the potential therapeutic role of a

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